2,205 results match your criteria Nature Reviews Genetics [Journal]


3D genome shows its stripes in gene-rich regions.

Nat Rev Genet 2019 Feb 20. Epub 2019 Feb 20.

Associate Editor, Nature Communications, .

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http://dx.doi.org/10.1038/s41576-019-0102-xDOI Listing
February 2019

Getting the drop on chromatin interaction.

Authors:
Linda Koch

Nat Rev Genet 2019 Feb 19. Epub 2019 Feb 19.

Nature Reviews Genetics, .

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http://dx.doi.org/10.1038/s41576-019-0103-9DOI Listing
February 2019

Telomeres and telomerase: three decades of progress.

Nat Rev Genet 2019 Feb 13. Epub 2019 Feb 13.

Department of Cell Biology, UT Southwestern Medical Center, Dallas, TX, USA.

Many recent advances have emerged in the telomere and telomerase fields. This Timeline article highlights the key advances that have expanded our views on the mechanistic underpinnings of telomeres and telomerase and their roles in ageing and disease. Three decades ago, the classic view was that telomeres protected the natural ends of linear chromosomes and that telomerase was a specific telomere-terminal transferase necessary for the replication of chromosome ends in single-celled organisms. Read More

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http://dx.doi.org/10.1038/s41576-019-0099-1DOI Listing
February 2019

A new Cas in town.

Authors:
Linda Koch

Nat Rev Genet 2019 Feb 8. Epub 2019 Feb 8.

Nature Reviews Genetics, .

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http://dx.doi.org/10.1038/s41576-019-0101-yDOI Listing
February 2019

Induced pluripotent stem cells in disease modelling and drug discovery.

Nat Rev Genet 2019 Feb 8. Epub 2019 Feb 8.

Boston Children's Hospital and Harvard Medical School, Boston, MA, USA.

The derivation of induced pluripotent stem cells (iPSCs) over a decade ago sparked widespread enthusiasm for the development of new models of human disease, enhanced platforms for drug discovery and more widespread use of autologous cell-based therapy. Early studies using directed differentiation of iPSCs frequently uncovered cell-level phenotypes in monogenic diseases, but translation to tissue-level and organ-level diseases has required development of more complex, 3D, multicellular systems. Organoids and human-rodent chimaeras more accurately mirror the diverse cellular ecosystems of complex tissues and are being applied to iPSC disease models to recapitulate the pathobiology of a broad spectrum of human maladies, including infectious diseases, genetic disorders and cancer. Read More

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http://dx.doi.org/10.1038/s41576-019-0100-zDOI Listing
February 2019

Integrative single-cell analysis.

Nat Rev Genet 2019 Jan 29. Epub 2019 Jan 29.

New York Genome Center, New York, NY, USA.

The recent maturation of single-cell RNA sequencing (scRNA-seq) technologies has coincided with transformative new methods to profile genetic, epigenetic, spatial, proteomic and lineage information in individual cells. This provides unique opportunities, alongside computational challenges, for integrative methods that can jointly learn across multiple types of data. Integrated analysis can discover relationships across cellular modalities, learn a holistic representation of the cell state, and enable the pooling of data sets produced across individuals and technologies. Read More

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http://dx.doi.org/10.1038/s41576-019-0093-7DOI Listing
January 2019

The long and the short of it.

Authors:
Linda Koch

Nat Rev Genet 2019 Mar;20(3):131

Nature Reviews Genetics, .

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http://dx.doi.org/10.1038/s41576-019-0098-2DOI Listing

Learning the language of splicing.

Authors:
Dorothy Clyde

Nat Rev Genet 2019 Mar;20(3):132-133

Nature Reviews Genetics, .

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http://dx.doi.org/10.1038/s41576-019-0097-3DOI Listing

Chromatin accessibility and the regulatory epigenome.

Nat Rev Genet 2019 Jan 23. Epub 2019 Jan 23.

Department of Genetics, Stanford University, Stanford, CA, USA.

Physical access to DNA is a highly dynamic property of chromatin that plays an essential role in establishing and maintaining cellular identity. The organization of accessible chromatin across the genome reflects a network of permissible physical interactions through which enhancers, promoters, insulators and chromatin-binding factors cooperatively regulate gene expression. This landscape of accessibility changes dynamically in response to both external stimuli and developmental cues, and emerging evidence suggests that homeostatic maintenance of accessibility is itself dynamically regulated through a competitive interplay between chromatin-binding factors and nucleosomes. Read More

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http://dx.doi.org/10.1038/s41576-018-0089-8DOI Listing
January 2019
1 Read

Publisher Correction: Challenges in unsupervised clustering of single-cell RNA-seq data.

Nat Rev Genet 2019 Jan 22. Epub 2019 Jan 22.

Wellcome Sanger Institute, Wellcome Genome Campus, Hinxton, UK.

During typesetting of this article, errors were inadvertently introduced to the hyperlinked URLs of some of the clustering tools in table 1 (Seurat, CIDR, pcaReduce and mpath), as well as to the numbering of the bold-text annotations in the reference list. The article has now been corrected online. The editors apologize for this error. Read More

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http://dx.doi.org/10.1038/s41576-019-0095-5DOI Listing
January 2019
1 Read

Human protein mutagens found via bacteria.

Authors:
Darren J Burgess

Nat Rev Genet 2019 Mar;20(3):132-133

Nature Reviews Genetics, .

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http://dx.doi.org/10.1038/s41576-019-0096-4DOI Listing
March 2019
1 Read

Baby sequencing steps.

Authors:
Linda Koch

Nat Rev Genet 2019 Mar;20(3):133

Nature Reviews Genetics, .

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http://dx.doi.org/10.1038/s41576-019-0094-6DOI Listing
March 2019
2 Reads

Genomic imprinting disorders: lessons on how genome, epigenome and environment interact.

Nat Rev Genet 2019 Jan 15. Epub 2019 Jan 15.

Department of Environmental, Biological and Pharmaceutical Sciences and Technologies, University of Campania 'Luigi Vanvitelli', Caserta; Institute of Genetics and Biophysics 'Adriano Buzzati-Traverso' CNR, Napoli, Italy.

Genomic imprinting, the monoallelic and parent-of-origin-dependent expression of a subset of genes, is required for normal development, and its disruption leads to human disease. Imprinting defects can involve isolated or multilocus epigenetic changes that may have no evident genetic cause, or imprinting disruption can be traced back to alterations of cis-acting elements or trans-acting factors that control the establishment, maintenance and erasure of germline epigenetic imprints. Recent insights into the dynamics of the epigenome, including the effect of environmental factors, suggest that the developmental outcomes and heritability of imprinting disorders are influenced by interactions between the genome, the epigenome and the environment in germ cells and early embryos. Read More

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http://www.nature.com/articles/s41576-018-0092-0
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January 2019
7 Reads

A great-ape view of the gut microbiome.

Nat Rev Genet 2019 Jan 8. Epub 2019 Jan 8.

Department of Integrative Biology, University of Texas at Austin, Austin, TX, USA.

Humans assemble a specialized microbiome from a world teeming with diverse microorganisms. Comparison to the microbiomes of great apes provides a dimension that is indispensable to understanding how these microbial communities form, function and change. This evolutionary perspective exposes not only how human gut microbiomes have been shaped by our great-ape heritage but also the features that make humans unique, as exemplified by an expansive loss of bacterial and archaeal diversity and the identification of microbial lineages that have co-diversified with their hosts. Read More

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http://dx.doi.org/10.1038/s41576-018-0085-zDOI Listing
January 2019
2 Reads

Challenges in unsupervised clustering of single-cell RNA-seq data.

Nat Rev Genet 2019 Jan 7. Epub 2019 Jan 7.

Wellcome Sanger Institute, Wellcome Genome Campus, Hinxton, UK.

Single-cell RNA sequencing (scRNA-seq) allows researchers to collect large catalogues detailing the transcriptomes of individual cells. Unsupervised clustering is of central importance for the analysis of these data, as it is used to identify putative cell types. However, there are many challenges involved. Read More

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http://dx.doi.org/10.1038/s41576-018-0088-9DOI Listing
January 2019
2 Reads

The role of sex in the genomics of human complex traits.

Nat Rev Genet 2019 Mar;20(3):173-190

Section of Genetic Medicine, Department of Medicine, University of Chicago, Chicago, IL, USA.

Nearly all human complex traits and disease phenotypes exhibit some degree of sex differences, including differences in prevalence, age of onset, severity or disease progression. Until recently, the underlying genetic mechanisms of such sex differences have been largely unexplored. Advances in genomic technologies and analytical approaches are now enabling a deeper investigation into the effect of sex on human health traits. Read More

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http://www.nature.com/articles/s41576-018-0083-1
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March 2019
12 Reads

Genome editing for disease locus dissection.

Authors:
Darren J Burgess

Nat Rev Genet 2019 Feb;20(2):67

Nature Reviews Genetics, .

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http://dx.doi.org/10.1038/s41576-018-0091-1DOI Listing
February 2019
10 Reads

Mechanisms regulating zygotic genome activation.

Nat Rev Genet 2018 Dec 20. Epub 2018 Dec 20.

Department of Biomolecular Chemistry, University of Wisconsin School of Medicine and Public Health, Madison, WI, USA.

Following fertilization, the two specified gametes must unite to create an entirely new organism. The genome is initially transcriptionally quiescent, allowing the zygote to be reprogrammed into a totipotent state. Gradually, the genome is activated through a process known as the maternal-to-zygotic transition, which enables zygotic gene products to replace the maternal supply that initiated development. Read More

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http://dx.doi.org/10.1038/s41576-018-0087-xDOI Listing
December 2018
1 Read

Synthetic readers and writers for mammalian chromatin.

Nat Rev Genet 2019 Feb;20(2):68-69

Associate Editor, Nature Communications, .

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http://dx.doi.org/10.1038/s41576-018-0090-2DOI Listing
February 2019
1 Read

Deciphering bacterial epigenomes using modern sequencing technologies.

Nat Rev Genet 2019 Mar;20(3):157-172

Department of Genetics and Genomic Sciences and Icahn Institute for Genomics and Multiscale Biology, Icahn School of Medicine at Mount Sinai, New York, NY, USA.

Prokaryotic DNA contains three types of methylation: N6-methyladenine, N4-methylcytosine and 5-methylcytosine. The lack of tools to analyse the frequency and distribution of methylated residues in bacterial genomes has prevented a full understanding of their functions. Now, advances in DNA sequencing technology, including single-molecule, real-time sequencing and nanopore-based sequencing, have provided new opportunities for systematic detection of all three forms of methylated DNA at a genome-wide scale and offer unprecedented opportunities for achieving a more complete understanding of bacterial epigenomes. Read More

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http://dx.doi.org/10.1038/s41576-018-0081-3DOI Listing
March 2019
1 Read

Proximity-CLIP - close encounters of the RNA kind.

Authors:
Linda Koch

Nat Rev Genet 2019 Feb;20(2):68-69

Nature Reviews Genetics, .

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http://dx.doi.org/10.1038/s41576-018-0086-yDOI Listing
February 2019
2 Reads

Integrating behavioural health tracking in human genetics research.

Nat Rev Genet 2019 Mar;20(3):129-130

Center for Behavioral Intervention Technologies, Northwestern University, Chicago, IL, USA.

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http://dx.doi.org/10.1038/s41576-018-0078-yDOI Listing
March 2019
1 Read

Risk loci for ADHD.

Authors:
Dorothy Clyde

Nat Rev Genet 2019 Feb;20(2):69

Nature Reviews Genetics, .

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http://dx.doi.org/10.1038/s41576-018-0084-0DOI Listing
February 2019
1 Read

Harnessing genomic information for livestock improvement.

Nat Rev Genet 2019 Mar;20(3):135-156

Queensland Alliance for Agriculture and Food Innovation (QAAFI), Queensland Bioscience Precinct, The University of Queensland, Brisbane, Queensland, Australia.

The world demand for animal-based food products is anticipated to increase by 70% by 2050. Meeting this demand in a way that has a minimal impact on the environment will require the implementation of advanced technologies, and methods to improve the genetic quality of livestock are expected to play a large part. Over the past 10 years, genomic selection has been introduced in several major livestock species and has more than doubled genetic progress in some. Read More

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http://dx.doi.org/10.1038/s41576-018-0082-2DOI Listing
March 2019
1 Read

The value of genetic testing for family health history of adopted persons.

Authors:
Thomas May

Nat Rev Genet 2019 Feb;20(2):65-66

Elson S. Floyd College of Medicine, Washington State University, Vancouver, WA, USA.

Lack of family health history experienced by most adopted persons can represent a marked disadvantage. This Comment discusses the role of genetic testing in filling this informational gap and the challenges that need to be overcome. Read More

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http://dx.doi.org/10.1038/s41576-018-0080-4DOI Listing
February 2019
1 Read

Clinical epigenetics: seizing opportunities for translation.

Nat Rev Genet 2019 Feb;20(2):109-127

Cancer Epigenetics and Biology Program (PEBC), Bellvitge Biomedical Biomedical Research Institute (IDIBELL), Barcelona, Catalonia, Spain.

Biomarker discovery and validation are necessary for improving the prediction of clinical outcomes and patient monitoring. Despite considerable interest in biomarker discovery and development, improvements in the range and quality of biomarkers are still needed. The main challenge is how to integrate preclinical data to obtain a reliable biomarker that can be measured with acceptable costs in routine clinical practice. Read More

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http://dx.doi.org/10.1038/s41576-018-0074-2DOI Listing
February 2019
1 Read

Testing the generality of non-genetic inheritance.

Authors:
Darren J Burgess

Nat Rev Genet 2019 Jan;20(1)

Nature Reviews Genetics, .

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http://www.nature.com/articles/s41576-018-0079-x
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January 2019
4 Reads

The oracle of inDelphi predicts Cas9 repair outcomes.

Authors:
Ross Cloney

Nat Rev Genet 2019 Jan;20(1):4-5

Senior Editor, Nature Communications, .

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http://dx.doi.org/10.1038/s41576-018-0077-zDOI Listing
January 2019
1 Read

PIWI-interacting RNAs: small RNAs with big functions.

Nat Rev Genet 2019 Feb;20(2):89-108

RNA Therapeutics Institute and Howard Hughes Medical Institute, University of Massachusetts Medical School, Worcester, MA, USA.

In animals, PIWI-interacting RNAs (piRNAs) of 21-35 nucleotides in length silence transposable elements, regulate gene expression and fight viral infection. piRNAs guide PIWI proteins to cleave target RNA, promote heterochromatin assembly and methylate DNA. The architecture of the piRNA pathway allows it both to provide adaptive, sequence-based immunity to rapidly evolving viruses and transposons and to regulate conserved host genes. Read More

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http://www.nature.com/articles/s41576-018-0073-3
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February 2019
14 Reads

Personalized DNA methylomics.

Nat Rev Genet 2019 Jan;20(1):4-5

Nature Reviews Genetics, .

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http://www.nature.com/articles/s41576-018-0076-0
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January 2019
7 Reads

Cancer chromatin accessed.

Nat Rev Genet 2019 Jan;20(1)

Associate Editor, Nature Communications, .

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http://dx.doi.org/10.1038/s41576-018-0075-1DOI Listing
January 2019
1 Read

Current and future perspectives of liquid biopsies in genomics-driven oncology.

Nat Rev Genet 2019 Feb;20(2):71-88

Institute of Human Genetics, Diagnostic and Research Center for Molecular BioMedicine, Medical University of Graz, Graz, Austria.

Precision oncology seeks to leverage molecular information about cancer to improve patient outcomes. Tissue biopsy samples are widely used to characterize tumours but are limited by constraints on sampling frequency and their incomplete representation of the entire tumour bulk. Now, attention is turning to minimally invasive liquid biopsies, which enable analysis of tumour components (including circulating tumour cells and circulating tumour DNA) in bodily fluids such as blood. Read More

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http://www.nature.com/articles/s41576-018-0071-5
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February 2019
116 Reads

The many lives of KATs - detectors, integrators and modulators of the cellular environment.

Nat Rev Genet 2019 Jan;20(1):7-23

Max Planck Institute of Immunobiology and Epigenetics, Freiburg im Breisgau, Germany.

Research over the past three decades has firmly established lysine acetyltransferases (KATs) as central players in regulating transcription. Recent advances in genomic sequencing, metabolomics, animal models and mass spectrometry technologies have uncovered unexpected new roles for KATs at the nexus between the environment and transcriptional regulation. Thousands of reversible acetylation sites have been mapped in the proteome that respond dynamically to the cellular milieu and maintain major processes such as metabolism, autophagy and stress response. Read More

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http://www.nature.com/articles/s41576-018-0072-4
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January 2019
6 Reads

Autism spectrum disorder: insights into convergent mechanisms from transcriptomics.

Nat Rev Genet 2019 Jan;20(1):51-63

Department of Molecular Genetics, University of Toronto, Toronto, Ontario, Canada.

Heredity has a major role in autism spectrum disorder (ASD), yet underlying causal genetic variants have been defined only in a fairly small subset of cases. The enormous genetic heterogeneity associated with ASD emphasizes the importance of identifying convergent pathways and molecular mechanisms that are responsible for this disorder. We review how recent transcriptomic analyses have transformed our understanding of pathway convergence in ASD. Read More

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http://www.nature.com/articles/s41576-018-0066-2
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January 2019
12 Reads
36.980 Impact Factor

The causes of evolvability and their evolution.

Nat Rev Genet 2019 Jan;20(1):24-38

Department of Evolutionary Biology and Environmental Studies, University of Zurich, Zurich, Switzerland.

Evolvability is the ability of a biological system to produce phenotypic variation that is both heritable and adaptive. It has long been the subject of anecdotal observations and theoretical work. In recent years, however, the molecular causes of evolvability have been an increasing focus of experimental work. Read More

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http://www.nature.com/articles/s41576-018-0069-z
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January 2019
6 Reads

Organizational principles of 3D genome architecture.

Nat Rev Genet 2018 Dec;19(12):789-800

Department of Biology, Emory University, Atlanta, GA, USA.

Studies of 3D chromatin organization have suggested that chromosomes are hierarchically organized into large compartments composed of smaller domains called topologically associating domains (TADs). Recent evidence suggests that compartments are smaller than previously thought and that the transcriptional or chromatin state is responsible for interactions leading to the formation of small compartmental domains in all organisms. In vertebrates, CTCF forms loop domains, probably via an extrusion process involving cohesin. Read More

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http://dx.doi.org/10.1038/s41576-018-0060-8DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6312108PMC
December 2018
3 Reads

Spotlight on nucleosomes.

Authors:
Dorothy Clyde

Nat Rev Genet 2018 Dec;19(12):738-739

Nature Reviews Genetics, .

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http://dx.doi.org/10.1038/s41576-018-0070-6DOI Listing
December 2018
1 Read

Coaching from the sidelines: the nuclear periphery in genome regulation.

Nat Rev Genet 2019 Jan;20(1):39-50

Molecular and Cell Biology Laboratory, The Salk Institute for Biological Studies, La Jolla, CA, USA.

The genome is packaged and organized nonrandomly within the 3D space of the nucleus to promote efficient gene expression and to faithfully maintain silencing of heterochromatin. The genome is enclosed within the nucleus by the nuclear envelope membrane, which contains a set of proteins that actively participate in chromatin organization and gene regulation. Technological advances are providing views of genome organization at unprecedented resolution and are beginning to reveal the ways that cells co-opt the structures of the nuclear periphery for nuclear organization and gene regulation. Read More

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http://www.nature.com/articles/s41576-018-0063-5
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http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6355253PMC
January 2019
22 Reads

Going to the negative: genomics for optimized medical prescription.

Authors:
Greg Gibson

Nat Rev Genet 2019 Jan;20(1):1-2

Georgia Institute of Technology, School of Biological Sciences, Krone EBB, Atlanta, USA.

Personalized medicine promises to advance and improve health by targeting the right medication to the right person at the right time, thus maximizing the proportion of treated patients who achieve an effective response to therapy. This Comment article makes the complementary argument that equally important benefits will derive from negative prediction, namely by identifying those individuals who are either not actually in need of, or unlikely to respond to, a drug. Reduction of unnecessary prescription could conceivably save health-care systems many billions of dollars with very little detrimental impact on outcomes. Read More

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http://www.nature.com/articles/s41576-018-0061-7
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January 2019
8 Reads

UK Biobank - a new era in genomic medicine.

Authors:
Orli G Bahcall

Nat Rev Genet 2018 Dec;19(12):737

Senior Editor, Nature, .

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http://www.nature.com/articles/s41576-018-0065-3
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December 2018
9 Reads

Navigating mouse cell types.

Authors:
Darren J Burgess

Nat Rev Genet 2018 Dec;19(12):739

Nature Reviews Genetics, .

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http://dx.doi.org/10.1038/s41576-018-0067-1DOI Listing
December 2018
1 Read

Publisher Correction: Base editing: precision chemistry on the genome and transcriptome of living cells.

Nat Rev Genet 2018 Dec;19(12):801

Merkin Institute of Transformative Technologies in Healthcare, Broad Institute of MIT and Harvard, Cambridge, MA, USA.

The originally published article contained errors in reference numbering throughout table 1 (DNA base editors and their approximate editing windows) due to the unintended propagation of reference numbering from an earlier version of the table. The article has now been corrected online. The editors apologize for this error. Read More

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http://www.nature.com/articles/s41576-018-0068-0
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December 2018
18 Reads
36.980 Impact Factor

Altered splicing in Alzheimer transcriptomes.

Authors:
Linda Koch

Nat Rev Genet 2018 Dec;19(12):738-739

Nature Reviews Genetics, .

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http://dx.doi.org/10.1038/s41576-018-0064-4DOI Listing
December 2018
1 Read

Publisher Correction: Towards quantitative and multiplexed in vivo functional cancer genomics.

Nat Rev Genet 2018 Dec;19(12):801

Department of Genetics, Stanford University School of Medicine, Stanford, CA, USA.

The originally published article failed to acknowledge the equal first authorship contribution of I. P. Winters and C. Read More

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http://www.nature.com/articles/s41576-018-0062-6
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December 2018
12 Reads

Base editing: precision chemistry on the genome and transcriptome of living cells.

Nat Rev Genet 2018 Dec;19(12):770-788

Merkin Institute of Transformative Technologies in Healthcare, Broad Institute of MIT and Harvard, Cambridge, MA, USA.

RNA-guided programmable nucleases from CRISPR systems generate precise breaks in DNA or RNA at specified positions. In cells, this activity can lead to changes in DNA sequence or RNA transcript abundance. Base editing is a newer genome-editing approach that uses components from CRISPR systems together with other enzymes to directly install point mutations into cellular DNA or RNA without making double-stranded DNA breaks. Read More

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http://www.nature.com/articles/s41576-018-0059-1
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December 2018
25 Reads
36.980 Impact Factor

The phylogenomics of evolving virus virulence.

Nat Rev Genet 2018 Dec;19(12):756-769

Marie Bashir Institute for Infectious Diseases and Biosecurity, Charles Perkins Centre, School of Life and Environmental Sciences and Sydney Medical School, The University of Sydney, Sydney, New South Wales, Australia.

How virulence evolves after a virus jumps to a new host species is central to disease emergence. Our current understanding of virulence evolution is based on insights drawn from two perspectives that have developed largely independently: long-standing evolutionary theory based on limited real data examples that often lack a genomic basis, and experimental studies of virulence-determining mutations using cell culture or animal models. A more comprehensive understanding of virulence mutations and their evolution can be achieved by bridging the gap between these two research pathways through the phylogenomic analysis of virus genome sequence data as a guide to experimental study. Read More

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http://dx.doi.org/10.1038/s41576-018-0055-5DOI Listing
December 2018
1 Read

The importance of genetic counselling in genome-wide sequencing.

Nat Rev Genet 2018 Dec;19(12):735-736

Department of Medical Genetics, University of British Columbia, Vancouver, British Columbia, Canada.

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http://www.nature.com/articles/s41576-018-0057-3
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December 2018
2 Reads

Author Correction: A comparison of tools for the simulation of genomic next-generation sequencing data.

Nat Rev Genet 2018 Nov;19(11):733

Department of Biochemistry, Genetics and Immunology, University of Vigo, Vigo, 36310, Spain.

The originally published article contained errors in Fig. 1 (Decision tree for the selection of a suitable NGS genomic simulator), whereby the labels 'Variants' and 'No Variants' had been switched. The correct figure is presented in this notice. Read More

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http://dx.doi.org/10.1038/s41576-018-0058-2DOI Listing
November 2018
1 Read

Putting genetic variants to a fitness test.

Nat Rev Genet 2018 Nov;19(11):667

Associate Editor, Nature Communications, .

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http://www.nature.com/articles/s41576-018-0056-4
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November 2018
2 Reads

Towards quantitative and multiplexed in vivo functional cancer genomics.

Nat Rev Genet 2018 Dec;19(12):741-755

Department of Genetics, Stanford University School of Medicine, Stanford, CA, USA.

Large-scale sequencing of human tumours has uncovered a vast array of genomic alterations. Genetically engineered mouse models recapitulate many features of human cancer and have been instrumental in assigning biological meaning to specific cancer-associated alterations. However, their time, cost and labour-intensive nature limits their broad utility; thus, the functional importance of the majority of genomic aberrations in cancer remains unknown. Read More

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http://www.nature.com/articles/s41576-018-0053-7
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December 2018
30 Reads