2,186 results match your criteria Nature Reviews Genetics [Journal]


Deciphering bacterial epigenomes using modern sequencing technologies.

Nat Rev Genet 2018 Dec 13. Epub 2018 Dec 13.

Department of Genetics and Genomic Sciences and Icahn Institute for Genomics and Multiscale Biology, Icahn School of Medicine at Mount Sinai, New York, NY, USA.

Prokaryotic DNA contains three types of methylation: N6-methyladenine, N4-methylcytosine and 5-methylcytosine. The lack of tools to analyse the frequency and distribution of methylated residues in bacterial genomes has prevented a full understanding of their functions. Now, advances in DNA sequencing technology, including single-molecule, real-time sequencing and nanopore-based sequencing, have provided new opportunities for systematic detection of all three forms of methylated DNA at a genome-wide scale and offer unprecedented opportunities for achieving a more complete understanding of bacterial epigenomes. Read More

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http://dx.doi.org/10.1038/s41576-018-0081-3DOI Listing
December 2018

Proximity-CLIP - close encounters of the RNA kind.

Authors:
Linda Koch

Nat Rev Genet 2018 Dec 12. Epub 2018 Dec 12.

Nature Reviews Genetics, .

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http://dx.doi.org/10.1038/s41576-018-0086-yDOI Listing
December 2018
1 Read

Integrating behavioural health tracking in human genetics research.

Nat Rev Genet 2018 Dec 6. Epub 2018 Dec 6.

Center for Behavioral Intervention Technologies, Northwestern University, Chicago, IL, USA.

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http://dx.doi.org/10.1038/s41576-018-0078-yDOI Listing
December 2018

Risk loci for ADHD.

Authors:
Dorothy Clyde

Nat Rev Genet 2018 Dec 7. Epub 2018 Dec 7.

Nature Reviews Genetics, .

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http://dx.doi.org/10.1038/s41576-018-0084-0DOI Listing
December 2018

Harnessing genomic information for livestock improvement.

Nat Rev Genet 2018 Dec 4. Epub 2018 Dec 4.

Queensland Alliance for Agriculture and Food Innovation (QAAFI), Queensland Bioscience Precinct, The University of Queensland, Brisbane, Queensland, Australia.

The world demand for animal-based food products is anticipated to increase by 70% by 2050. Meeting this demand in a way that has a minimal impact on the environment will require the implementation of advanced technologies, and methods to improve the genetic quality of livestock are expected to play a large part. Over the past 10 years, genomic selection has been introduced in several major livestock species and has more than doubled genetic progress in some. Read More

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http://dx.doi.org/10.1038/s41576-018-0082-2DOI Listing
December 2018

The value of genetic testing for family health history of adopted persons.

Authors:
Thomas May

Nat Rev Genet 2018 Nov 29. Epub 2018 Nov 29.

Elson S. Floyd College of Medicine, Washington State University, Vancouver, WA, USA.

Lack of family health history experienced by most adopted persons can represent a marked disadvantage. This Comment discusses the role of genetic testing in filling this informational gap and the challenges that need to be overcome. Read More

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http://dx.doi.org/10.1038/s41576-018-0080-4DOI Listing
November 2018

Clinical epigenetics: seizing opportunities for translation.

Nat Rev Genet 2018 Nov 27. Epub 2018 Nov 27.

Cancer Epigenetics and Biology Program (PEBC), Bellvitge Biomedical Biomedical Research Institute (IDIBELL), Barcelona, Catalonia, Spain.

Biomarker discovery and validation are necessary for improving the prediction of clinical outcomes and patient monitoring. Despite considerable interest in biomarker discovery and development, improvements in the range and quality of biomarkers are still needed. The main challenge is how to integrate preclinical data to obtain a reliable biomarker that can be measured with acceptable costs in routine clinical practice. Read More

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http://dx.doi.org/10.1038/s41576-018-0074-2DOI Listing
November 2018

Testing the generality of non-genetic inheritance.

Authors:
Darren J Burgess

Nat Rev Genet 2019 Jan;20(1)

Nature Reviews Genetics, .

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http://dx.doi.org/10.1038/s41576-018-0079-xDOI Listing
January 2019

The oracle of inDelphi predicts Cas9 repair outcomes.

Authors:
Ross Cloney

Nat Rev Genet 2019 Jan;20(1):4-5

Senior Editor, Nature Communications, .

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http://dx.doi.org/10.1038/s41576-018-0077-zDOI Listing
January 2019

PIWI-interacting RNAs: small RNAs with big functions.

Nat Rev Genet 2018 Nov 16. Epub 2018 Nov 16.

RNA Therapeutics Institute and Howard Hughes Medical Institute, University of Massachusetts Medical School, Worcester, MA, USA.

In animals, PIWI-interacting RNAs (piRNAs) of 21-35 nucleotides in length silence transposable elements, regulate gene expression and fight viral infection. piRNAs guide PIWI proteins to cleave target RNA, promote heterochromatin assembly and methylate DNA. The architecture of the piRNA pathway allows it both to provide adaptive, sequence-based immunity to rapidly evolving viruses and transposons and to regulate conserved host genes. Read More

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http://www.nature.com/articles/s41576-018-0073-3
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November 2018
9 Reads

Personalized DNA methylomics.

Nat Rev Genet 2019 Jan;20(1):4-5

Nature Reviews Genetics, .

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http://www.nature.com/articles/s41576-018-0076-0
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January 2019
2 Reads

Cancer chromatin accessed.

Nat Rev Genet 2019 Jan;20(1)

Associate Editor, Nature Communications, .

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http://dx.doi.org/10.1038/s41576-018-0075-1DOI Listing
January 2019

Current and future perspectives of liquid biopsies in genomics-driven oncology.

Nat Rev Genet 2018 Nov 8. Epub 2018 Nov 8.

Institute of Human Genetics, Diagnostic and Research Center for Molecular BioMedicine, Medical University of Graz, Graz, Austria.

Precision oncology seeks to leverage molecular information about cancer to improve patient outcomes. Tissue biopsy samples are widely used to characterize tumours but are limited by constraints on sampling frequency and their incomplete representation of the entire tumour bulk. Now, attention is turning to minimally invasive liquid biopsies, which enable analysis of tumour components (including circulating tumour cells and circulating tumour DNA) in bodily fluids such as blood. Read More

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https://www.nature.com/articles/s41576-018-0071-5.pdf
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http://www.nature.com/articles/s41576-018-0071-5
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http://dx.doi.org/10.1038/s41576-018-0071-5DOI Listing
November 2018
88 Reads

The many lives of KATs - detectors, integrators and modulators of the cellular environment.

Nat Rev Genet 2019 Jan;20(1):7-23

Max Planck Institute of Immunobiology and Epigenetics, Freiburg im Breisgau, Germany.

Research over the past three decades has firmly established lysine acetyltransferases (KATs) as central players in regulating transcription. Recent advances in genomic sequencing, metabolomics, animal models and mass spectrometry technologies have uncovered unexpected new roles for KATs at the nexus between the environment and transcriptional regulation. Thousands of reversible acetylation sites have been mapped in the proteome that respond dynamically to the cellular milieu and maintain major processes such as metabolism, autophagy and stress response. Read More

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http://www.nature.com/articles/s41576-018-0072-4
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January 2019
2 Reads

Autism spectrum disorder: insights into convergent mechanisms from transcriptomics.

Nat Rev Genet 2019 Jan;20(1):51-63

Department of Molecular Genetics, University of Toronto, Toronto, Ontario, Canada.

Heredity has a major role in autism spectrum disorder (ASD), yet underlying causal genetic variants have been defined only in a fairly small subset of cases. The enormous genetic heterogeneity associated with ASD emphasizes the importance of identifying convergent pathways and molecular mechanisms that are responsible for this disorder. We review how recent transcriptomic analyses have transformed our understanding of pathway convergence in ASD. Read More

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http://www.nature.com/articles/s41576-018-0066-2
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January 2019
5 Reads
36.980 Impact Factor

The causes of evolvability and their evolution.

Nat Rev Genet 2019 Jan;20(1):24-38

Department of Evolutionary Biology and Environmental Studies, University of Zurich, Zurich, Switzerland.

Evolvability is the ability of a biological system to produce phenotypic variation that is both heritable and adaptive. It has long been the subject of anecdotal observations and theoretical work. In recent years, however, the molecular causes of evolvability have been an increasing focus of experimental work. Read More

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http://www.nature.com/articles/s41576-018-0069-z
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January 2019
5 Reads

Organizational principles of 3D genome architecture.

Nat Rev Genet 2018 Dec;19(12):789-800

Department of Biology, Emory University, Atlanta, GA, USA.

Studies of 3D chromatin organization have suggested that chromosomes are hierarchically organized into large compartments composed of smaller domains called topologically associating domains (TADs). Recent evidence suggests that compartments are smaller than previously thought and that the transcriptional or chromatin state is responsible for interactions leading to the formation of small compartmental domains in all organisms. In vertebrates, CTCF forms loop domains, probably via an extrusion process involving cohesin. Read More

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http://dx.doi.org/10.1038/s41576-018-0060-8DOI Listing
December 2018
2 Reads

Spotlight on nucleosomes.

Authors:
Dorothy Clyde

Nat Rev Genet 2018 Dec;19(12):738-739

Nature Reviews Genetics, .

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http://dx.doi.org/10.1038/s41576-018-0070-6DOI Listing
December 2018

Coaching from the sidelines: the nuclear periphery in genome regulation.

Nat Rev Genet 2019 Jan;20(1):39-50

Molecular and Cell Biology Laboratory, The Salk Institute for Biological Studies, La Jolla, CA, USA.

The genome is packaged and organized nonrandomly within the 3D space of the nucleus to promote efficient gene expression and to faithfully maintain silencing of heterochromatin. The genome is enclosed within the nucleus by the nuclear envelope membrane, which contains a set of proteins that actively participate in chromatin organization and gene regulation. Technological advances are providing views of genome organization at unprecedented resolution and are beginning to reveal the ways that cells co-opt the structures of the nuclear periphery for nuclear organization and gene regulation. Read More

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http://www.nature.com/articles/s41576-018-0063-5
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January 2019
14 Reads

Going to the negative: genomics for optimized medical prescription.

Authors:
Greg Gibson

Nat Rev Genet 2019 Jan;20(1):1-2

Georgia Institute of Technology, School of Biological Sciences, Krone EBB, Atlanta, USA.

Personalized medicine promises to advance and improve health by targeting the right medication to the right person at the right time, thus maximizing the proportion of treated patients who achieve an effective response to therapy. This Comment article makes the complementary argument that equally important benefits will derive from negative prediction, namely by identifying those individuals who are either not actually in need of, or unlikely to respond to, a drug. Reduction of unnecessary prescription could conceivably save health-care systems many billions of dollars with very little detrimental impact on outcomes. Read More

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http://www.nature.com/articles/s41576-018-0061-7
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January 2019
4 Reads

UK Biobank - a new era in genomic medicine.

Authors:
Orli G Bahcall

Nat Rev Genet 2018 Dec;19(12):737

Senior Editor, Nature, .

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http://www.nature.com/articles/s41576-018-0065-3
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December 2018
2 Reads

Navigating mouse cell types.

Authors:
Darren J Burgess

Nat Rev Genet 2018 Dec;19(12):739

Nature Reviews Genetics, .

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http://dx.doi.org/10.1038/s41576-018-0067-1DOI Listing
December 2018

Publisher Correction: Base editing: precision chemistry on the genome and transcriptome of living cells.

Nat Rev Genet 2018 Dec;19(12):801

Merkin Institute of Transformative Technologies in Healthcare, Broad Institute of MIT and Harvard, Cambridge, MA, USA.

The originally published article contained errors in reference numbering throughout table 1 (DNA base editors and their approximate editing windows) due to the unintended propagation of reference numbering from an earlier version of the table. The article has now been corrected online. The editors apologize for this error. Read More

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http://www.nature.com/articles/s41576-018-0068-0
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December 2018
12 Reads
36.980 Impact Factor

Altered splicing in Alzheimer transcriptomes.

Authors:
Linda Koch

Nat Rev Genet 2018 Dec;19(12):738-739

Nature Reviews Genetics, .

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http://dx.doi.org/10.1038/s41576-018-0064-4DOI Listing
December 2018

Publisher Correction: Towards quantitative and multiplexed in vivo functional cancer genomics.

Nat Rev Genet 2018 Dec;19(12):801

Department of Genetics, Stanford University School of Medicine, Stanford, CA, USA.

The originally published article failed to acknowledge the equal first authorship contribution of I. P. Winters and C. Read More

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http://www.nature.com/articles/s41576-018-0062-6
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December 2018
7 Reads

Base editing: precision chemistry on the genome and transcriptome of living cells.

Nat Rev Genet 2018 Dec;19(12):770-788

Merkin Institute of Transformative Technologies in Healthcare, Broad Institute of MIT and Harvard, Cambridge, MA, USA.

RNA-guided programmable nucleases from CRISPR systems generate precise breaks in DNA or RNA at specified positions. In cells, this activity can lead to changes in DNA sequence or RNA transcript abundance. Base editing is a newer genome-editing approach that uses components from CRISPR systems together with other enzymes to directly install point mutations into cellular DNA or RNA without making double-stranded DNA breaks. Read More

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http://www.nature.com/articles/s41576-018-0059-1
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December 2018
17 Reads
36.980 Impact Factor

The phylogenomics of evolving virus virulence.

Nat Rev Genet 2018 Dec;19(12):756-769

Marie Bashir Institute for Infectious Diseases and Biosecurity, Charles Perkins Centre, School of Life and Environmental Sciences and Sydney Medical School, The University of Sydney, Sydney, New South Wales, Australia.

How virulence evolves after a virus jumps to a new host species is central to disease emergence. Our current understanding of virulence evolution is based on insights drawn from two perspectives that have developed largely independently: long-standing evolutionary theory based on limited real data examples that often lack a genomic basis, and experimental studies of virulence-determining mutations using cell culture or animal models. A more comprehensive understanding of virulence mutations and their evolution can be achieved by bridging the gap between these two research pathways through the phylogenomic analysis of virus genome sequence data as a guide to experimental study. Read More

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http://dx.doi.org/10.1038/s41576-018-0055-5DOI Listing
December 2018

The importance of genetic counselling in genome-wide sequencing.

Nat Rev Genet 2018 Dec;19(12):735-736

Department of Medical Genetics, University of British Columbia, Vancouver, British Columbia, Canada.

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http://www.nature.com/articles/s41576-018-0057-3
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December 2018
1 Read

Author Correction: A comparison of tools for the simulation of genomic next-generation sequencing data.

Nat Rev Genet 2018 Nov;19(11):733

Department of Biochemistry, Genetics and Immunology, University of Vigo, Vigo, 36310, Spain.

The originally published article contained errors in Fig. 1 (Decision tree for the selection of a suitable NGS genomic simulator), whereby the labels 'Variants' and 'No Variants' had been switched. The correct figure is presented in this notice. Read More

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http://dx.doi.org/10.1038/s41576-018-0058-2DOI Listing
November 2018

Putting genetic variants to a fitness test.

Nat Rev Genet 2018 Nov;19(11):667

Associate Editor, Nature Communications, .

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http://www.nature.com/articles/s41576-018-0056-4
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November 2018
1 Read

Towards quantitative and multiplexed in vivo functional cancer genomics.

Nat Rev Genet 2018 Dec;19(12):741-755

Department of Genetics, Stanford University School of Medicine, Stanford, CA, USA.

Large-scale sequencing of human tumours has uncovered a vast array of genomic alterations. Genetically engineered mouse models recapitulate many features of human cancer and have been instrumental in assigning biological meaning to specific cancer-associated alterations. However, their time, cost and labour-intensive nature limits their broad utility; thus, the functional importance of the majority of genomic aberrations in cancer remains unknown. Read More

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http://www.nature.com/articles/s41576-018-0053-7
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December 2018
16 Reads

DNA-based memory devices for recording cellular events.

Nat Rev Genet 2018 Nov;19(11):718-732

Department of Systems Biology, Columbia University Medical Center, New York, NY, USA.

Measuring biological data across time and space is critical for understanding complex biological processes and for various biosurveillance applications. However, such data are often inaccessible or difficult to directly obtain. Less invasive, more robust and higher-throughput biological recording tools are needed to profile cells and their environments. Read More

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http://dx.doi.org/10.1038/s41576-018-0052-8DOI Listing
November 2018

Computational tools to unmask transposable elements.

Nat Rev Genet 2018 Nov;19(11):688-704

Department of Human Genetics, McGill University, Montréal, Canada.

A substantial proportion of the genome of many species is derived from transposable elements (TEs). Moreover, through various self-copying mechanisms, TEs continue to proliferate in the genomes of most species. TEs have contributed numerous regulatory, transcript and protein innovations and have also been linked to disease. Read More

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http://dx.doi.org/10.1038/s41576-018-0050-xDOI Listing
November 2018

Progress and potential in organoid research.

Nat Rev Genet 2018 Nov;19(11):671-687

Laboratory of Stem Cell Bioengineering, Institute of Bioengineering, School of Life Sciences and School of Engineering, École Polytechnique Fédérale de Lausanne (EPFL), Lausanne, Switzerland.

Tissue and organ biology are very challenging to study in mammals, and progress can be hindered, particularly in humans, by sample accessibility and ethical concerns. However, advances in stem cell culture have made it possible to derive in vitro 3D tissues called organoids, which capture some of the key multicellular, anatomical and even functional hallmarks of real organs at the micrometre to millimetre scale. Recent studies have demonstrated that organoids can be used to model organ development and disease and have a wide range of applications in basic research, drug discovery and regenerative medicine. Read More

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http://dx.doi.org/10.1038/s41576-018-0051-9DOI Listing
November 2018
3 Reads

The girl with Neanderthal and Denisovan parents.

Authors:
Dorothy Clyde

Nat Rev Genet 2018 Nov;19(11):668-669

Nature Reviews Genetics, .

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http://dx.doi.org/10.1038/s41576-018-0054-6DOI Listing
November 2018

Full speed ahead for single-cell analysis.

Authors:
Darren J Burgess

Nat Rev Genet 2018 Nov;19(11):668-669

Nature Reviews Genetics, .

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http://dx.doi.org/10.1038/s41576-018-0049-3DOI Listing
November 2018

In vivo lineage tracing in mice.

Authors:
Linda Koch

Nat Rev Genet 2018 Nov;19(11):669

Nature Reviews Genetics, .

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http://dx.doi.org/10.1038/s41576-018-0048-4DOI Listing
November 2018

Understanding explosive diversification through cichlid fish genomics.

Nat Rev Genet 2018 Nov;19(11):705-717

Zoological Institute, Department of Environmental Sciences, University of Basel, Basel, Switzerland.

Owing to their taxonomic, phenotypic, ecological and behavioural diversity and propensity for explosive diversification, the assemblages of cichlid fish in the East African Great Lakes Victoria, Malawi and Tanganyika are important role models in evolutionary biology. With the release of five reference genomes and many additional genomic resources, as well as the establishment of functional genomic tools, the cichlid system has fully entered the genomic era. The in-depth genomic exploration of the East African cichlid fauna - in combination with the examination of their ecology, morphology and behaviour - permits novel insights into the way organisms diversify. Read More

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http://dx.doi.org/10.1038/s41576-018-0043-9DOI Listing
November 2018

Lessons from 1 million genomes.

Nat Rev Genet 2018 Oct;19(10):592-593

Nature Communications, .

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http://dx.doi.org/10.1038/s41576-018-0047-5DOI Listing
October 2018
3 Reads

FOXP2 tells a cautionary tale.

Authors:
Rebecca Furlong

Nat Rev Genet 2018 Oct;19(10):592-593

Nature Communications, .

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http://dx.doi.org/10.1038/s41576-018-0046-6DOI Listing
October 2018
1 Read

Stem cell bioengineering: building from stem cell biology.

Nat Rev Genet 2018 Oct;19(10):595-614

Institute of Biomaterials and Biomedical Engineering (IBBME) and The Donnelly Centre for Cellular and Biomolecular Research (CCBR), University of Toronto, Toronto, Ontario, Canada.

New fundamental discoveries in stem cell biology have yielded potentially transformative regenerative therapeutics. However, widespread implementation of stem-cell-derived therapeutics remains sporadic. Barriers that impede the development of these therapeutics can be linked to our incomplete understanding of how the regulatory networks that encode stem cell fate govern the development of the complex tissues and organs that are ultimately required for restorative function. Read More

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http://dx.doi.org/10.1038/s41576-018-0040-zDOI Listing
October 2018
36.980 Impact Factor

Transcriptomics in intact tissues.

Authors:
Linda Koch

Nat Rev Genet 2018 Oct;19(10):593

Nature Reviews Genetics, .

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http://dx.doi.org/10.1038/s41576-018-0045-7DOI Listing
October 2018

Evolution of eusociality.

Authors:
Linda Koch

Nat Rev Genet 2018 Oct;19(10):592

Nature Reviews Genetics, .

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http://dx.doi.org/10.1038/s41576-018-0044-8DOI Listing
October 2018

Dynamic RNAs in sperm shape embryo development.

Authors:
Ross Cloney

Nat Rev Genet 2018 Oct;19(10):591

Senior Editor, Nature Communications, .

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http://dx.doi.org/10.1038/s41576-018-0042-xDOI Listing
October 2018
9 Reads

High-throughput determination of RNA structures.

Nat Rev Genet 2018 Oct;19(10):615-634

Department of Chemical and Biological Engineering, Northwestern University, Evanston, IL, USA.

RNA performs and regulates a diverse range of cellular processes, with new functional roles being uncovered at a rapid pace. Interest is growing in how these functions are linked to RNA structures that form in the complex cellular environment. A growing suite of technologies that use advances in RNA structural probes, high-throughput sequencing and new computational approaches to interrogate RNA structure at unprecedented throughput are beginning to provide insights into RNA structures at new spatial, temporal and cellular scales. Read More

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http://dx.doi.org/10.1038/s41576-018-0034-xDOI Listing
October 2018
13 Reads

How to predict the future.

Authors:
Anna Dart

Nat Rev Genet 2018 Sep;19(9):531

Associate Editor, Nature Reviews Cancer, .

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http://dx.doi.org/10.1038/s41576-018-0041-yDOI Listing
September 2018

Koala genome insights.

Authors:
Darren J Burgess

Nat Rev Genet 2018 Sep;19(9):533

Nature Reviews Genetics, .

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http://dx.doi.org/10.1038/s41576-018-0039-5DOI Listing
September 2018
1 Read

Gold rush to gene-editing in the brain.

Nat Rev Genet 2018 Sep;19(9):532-533

Associate Editor, Nature Communications, .

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http://dx.doi.org/10.1038/s41576-018-0038-6DOI Listing
September 2018

Cytonuclear integration and co-evolution.

Nat Rev Genet 2018 Oct;19(10):635-648

Department of Biology, Colorado State University, Fort Collins, CO, USA.

The partitioning of genetic material between the nucleus and cytoplasmic (mitochondrial and plastid) genomes within eukaryotic cells necessitates coordinated integration between these genomic compartments, with important evolutionary and biomedical implications. Classic questions persist about the pervasive reduction of cytoplasmic genomes via a combination of gene loss, transfer and functional replacement - and yet why they are almost always retained in some minimal form. One striking consequence of cytonuclear integration is the existence of 'chimeric' enzyme complexes composed of subunits encoded in two different genomes. Read More

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http://dx.doi.org/10.1038/s41576-018-0035-9DOI Listing
October 2018
1 Read

Concentrating on intrinsic disorder.

Authors:
Paulina Strzyz

Nat Rev Genet 2018 Sep;19(9):534

Nature Reviews Molecular Cell Biology, .

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http://dx.doi.org/10.1038/s41576-018-0037-7DOI Listing
September 2018