497 results match your criteria Nature Reviews Gastroenterology & Hepatology[Journal]


Oesophageal atresia.

Nat Rev Dis Primers 2019 Apr 18;5(1):26. Epub 2019 Apr 18.

Emma Children's Hospital, Amsterdam UMC, University of Amsterdam, Pediatric Gastroenterology and Nutrition, Amsterdam, The Netherlands.

Oesophageal atresia (EA) is a congenital abnormality of the oesophagus that is caused by incomplete embryonic compartmentalization of the foregut. EA commonly occurs with a tracheo-oesophageal fistula (TEF). Associated birth defects or anomalies, such as VACTERL association, trisomy 18 or 21 and CHARGE syndrome, occur in the majority of patients born with EA. Read More

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http://www.nature.com/articles/s41572-019-0077-0
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http://dx.doi.org/10.1038/s41572-019-0077-0DOI Listing
April 2019
1 Read

Identifying a specific small molecule to reverse intestinal barrier loss.

Authors:
Hugh Thomas

Nat Rev Gastroenterol Hepatol 2019 Apr 16. Epub 2019 Apr 16.

Nature Reviews Gastroenterology & Hepatology, .

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http://www.nature.com/articles/s41575-019-0149-3
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http://dx.doi.org/10.1038/s41575-019-0149-3DOI Listing
April 2019
1 Read

A thirst-quenching gut-brain signal.

Authors:
Iain Dickson

Nat Rev Gastroenterol Hepatol 2019 Apr 12. Epub 2019 Apr 12.

Nature Reviews Gastroenterology & Hepatology, .

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http://dx.doi.org/10.1038/s41575-019-0147-5DOI Listing

LSEC stretch promotes fibrosis during hepatic vascular congestion.

Authors:
Hugh Thomas

Nat Rev Gastroenterol Hepatol 2019 Apr 10. Epub 2019 Apr 10.

Nature Reviews Gastroenterology & Hepatology, .

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http://dx.doi.org/10.1038/s41575-019-0146-6DOI Listing

IL-6 drives niche formation in pancreatic cancer liver metastasis.

Authors:
Hugh Thomas

Nat Rev Gastroenterol Hepatol 2019 Apr 5. Epub 2019 Apr 5.

Nature Reviews Gastroenterology & Hepatology, .

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http://dx.doi.org/10.1038/s41575-019-0138-6DOI Listing
April 2019
1 Read

Gastric bypass - weight loss and metabolic outcomes similar with OAGB versus RYGB.

Authors:
Katrina Ray

Nat Rev Gastroenterol Hepatol 2019 Mar 29. Epub 2019 Mar 29.

Nature Reviews Gastroenterology & Hepatology, .

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http://dx.doi.org/10.1038/s41575-019-0142-xDOI Listing

Metabolite crosstalk could modulate chemotherapy response in pancreatic cancer.

Authors:
Katrina Ray

Nat Rev Gastroenterol Hepatol 2019 Mar 29. Epub 2019 Mar 29.

Nature Reviews Gastroenterology & Hepatology, .

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http://dx.doi.org/10.1038/s41575-019-0143-9DOI Listing

Gut mucosal virome altered in ulcerative colitis.

Authors:
Katrina Ray

Nat Rev Gastroenterol Hepatol 2019 Mar 29. Epub 2019 Mar 29.

Nature Reviews Gastroenterology & Hepatology, .

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http://dx.doi.org/10.1038/s41575-019-0141-yDOI Listing

Coagulation and IBD - PAI1 provides the missing link.

Authors:
Katrina Ray

Nat Rev Gastroenterol Hepatol 2019 Mar 28. Epub 2019 Mar 28.

Nature Reviews Gastroenterology & Hepatology, .

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http://dx.doi.org/10.1038/s41575-019-0139-5DOI Listing

Neonatal cholestasis: emerging molecular diagnostics and potential novel therapeutics.

Nat Rev Gastroenterol Hepatol 2019 Mar 22. Epub 2019 Mar 22.

Pediatric Liver Center, Digestive Health Institute, Children's Hospital Colorado, Section of Pediatric Gastroenterology, Hepatology and Nutrition, University of Colorado School of Medicine, Aurora, CO, USA.

Neonatal cholestasis is a group of rare disorders of impaired bile flow characterized by conjugated hyperbilirubinaemia in the newborn and young infant. Neonatal cholestasis is never physiological but rather is a sign of hepatobiliary and/or metabolic disorders, some of which might be fatal if not identified and treated rapidly. A step-wise timely evaluation is essential to quickly identify those causes amenable to treatment and to offer accurate prognosis. Read More

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http://www.nature.com/articles/s41575-019-0132-z
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http://dx.doi.org/10.1038/s41575-019-0132-zDOI Listing
March 2019
3 Reads

Autophagy inhibitor combination strategies for pancreatic cancer.

Authors:
Iain Dickson

Nat Rev Gastroenterol Hepatol 2019 Mar 19. Epub 2019 Mar 19.

Nature Reviews Gastroenterology & Hepatology, .

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http://dx.doi.org/10.1038/s41575-019-0136-8DOI Listing

Pregnancy, psychiatry and IBD: multidisciplinary care is crucial.

Nat Rev Gastroenterol Hepatol 2019 Mar 19. Epub 2019 Mar 19.

Digestive Diseases Institute, Shaare Zedek Medical Center, Jerusalem, Israel.

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http://dx.doi.org/10.1038/s41575-019-0135-9DOI Listing
March 2019
1 Read

Cholangiocyte pathobiology.

Nat Rev Gastroenterol Hepatol 2019 Mar 8. Epub 2019 Mar 8.

Division of Gastroenterology and Hepatology, Mayo School of Medicine and Science, Mayo Clinic, Rochester, MN, USA.

Cholangiocytes, the epithelial cells lining the intrahepatic and extrahepatic bile ducts, are highly specialized cells residing in a complex anatomic niche where they participate in bile production and homeostasis. Cholangiocytes are damaged in a variety of human diseases termed cholangiopathies, often causing advanced liver failure. The regulation of cholangiocyte transport properties is increasingly understood, as is their anatomical and functional heterogeneity along the biliary tract. Read More

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http://dx.doi.org/10.1038/s41575-019-0125-yDOI Listing
March 2019
2 Reads

Mendelian randomization reveals causal effects of the gut microbiota.

Authors:
Hugh Thomas

Nat Rev Gastroenterol Hepatol 2019 Apr;16(4):198-199

Nature Reviews Gastroenterology & Hepatology, .

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http://dx.doi.org/10.1038/s41575-019-0133-yDOI Listing

Endoscopic Retrograde Cholangiopancreatography-Guided Ablation for Cholangiocarcinoma.

Gastrointest Endosc Clin N Am 2019 Apr 2;29(2):351-367. Epub 2019 Feb 2.

Division of Gastroenterology and Hepatology, University of Virginia, PO Box 800708, Charlottesville, VA 22908, USA. Electronic address:

Most patients with perihilar cholangiocarcinoma present with surgically unresectable disease owing to the insidious nature of this malignancy. Relief of malignant perihilar biliary obstruction is a key aspect of cholangiocarcinoma. Although palliative stenting using uncovered metal stents has been advocated in patients with unresectable malignant perihilar biliary strictures, several endoscopic retrograde cholangiopancreatography-guided ablative modalities have emerged. Read More

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http://dx.doi.org/10.1016/j.giec.2018.11.006DOI Listing
April 2019
5 Reads

Diet modulates T cell-induced colitis via microbial antigen expression.

Authors:
Iain Dickson

Nat Rev Gastroenterol Hepatol 2019 Apr;16(4):198-199

Nature Reviews Gastroenterology & Hepatology, .

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http://dx.doi.org/10.1038/s41575-019-0127-9DOI Listing

Autologous adipose tissue injection promising for treatment of perianal fistulas in Crohn's disease.

Authors:
Clemens Thoma

Nat Rev Gastroenterol Hepatol 2019 Apr;16(4):198

Nature Reviews Gastroenterology & Hepatology, .

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http://dx.doi.org/10.1038/s41575-019-0130-1DOI Listing

Substantial expansion of the human gut microbiota genome catalogue.

Authors:
Clemens Thoma

Nat Rev Gastroenterol Hepatol 2019 Apr;16(4):198

Nature Reviews Gastroenterology & Hepatology, .

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http://dx.doi.org/10.1038/s41575-019-0129-7DOI Listing

Bile salt hydrolases involved in the effectiveness of FMT for Clostridium difficile infection.

Authors:
Clemens Thoma

Nat Rev Gastroenterol Hepatol 2019 Apr;16(4):198

Nature Reviews Gastroenterology & Hepatology, .

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http://dx.doi.org/10.1038/s41575-019-0128-8DOI Listing

The gut mycobiota: insights into analysis, environmental interactions and role in gastrointestinal diseases.

Nat Rev Gastroenterol Hepatol 2019 Mar 1. Epub 2019 Mar 1.

Micalis Institute, INRA, AgroParisTech, Université Paris-Saclay, Jouy-en-Josas, France.

The gut microbiota is a dense and diverse ecosystem that is involved in many physiological functions as well as in disease pathogenesis. It is dominated by bacteria, which have been extensively studied in the past 15 years; however, other microorganisms, such as fungi, phages, archaea and protists, are also present in the gut microbiota. Exploration of the fungal component, namely, the mycobiota, is at an early stage, and several specific technical challenges are associated with mycobiota analysis. Read More

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http://dx.doi.org/10.1038/s41575-019-0121-2DOI Listing
March 2019
12.610 Impact Factor

IL-22 assures gut homeostasis.

Authors:
Clemens Thoma

Nat Rev Gastroenterol Hepatol 2019 Apr;16(4):199

Nature Reviews Gastroenterology & Hepatology, .

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http://dx.doi.org/10.1038/s41575-019-0124-zDOI Listing

Time for a change and to adopt a novel molecular genomic approach in NETs.

Nat Rev Clin Oncol 2019 Apr;16(4):269-270

Department of Surgery, Yale University School of Medicine, New Haven, CT, USA.

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http://dx.doi.org/10.1038/s41571-019-0185-5DOI Listing

Enteroendocrine cell lineage revealed by time-resolved differentiation map.

Authors:
Iain Dickson

Nat Rev Gastroenterol Hepatol 2019 Apr;16(4):197

Nature Reviews Gastroenterology & Hepatology, .

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http://dx.doi.org/10.1038/s41575-019-0122-1DOI Listing

Bacterial strains modulate CD8 T cell function and cancer immunity.

Authors:
Hugh Thomas

Nat Rev Gastroenterol Hepatol 2019 Mar;16(3):141

Nature Reviews Gastroenterology & Hepatology, .

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http://dx.doi.org/10.1038/s41575-019-0120-3DOI Listing

ACLF monocyte dysfunction.

Authors:
Clemens Thoma

Nat Rev Gastroenterol Hepatol 2019 Mar;16(3):140-141

Nature Reviews Gastroenterology & Hepatology, .

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http://dx.doi.org/10.1038/s41575-019-0119-9DOI Listing

Regulatory T cells in cancer immunosuppression - implications for anticancer therapy.

Nat Rev Clin Oncol 2019 Jan 31. Epub 2019 Jan 31.

Division of Cancer Immunology, Research Institute/Exploratory Oncology Research and Clinical Trial Centre (EPOC), National Cancer Centre, Tokyo/Chiba, Japan.

Regulatory T (T) cells, an immunosuppressive subset of CD4 T cells characterized by the expression of the master transcription factor forkhead box protein P3 (FOXP3), are a component of the immune system with essential roles in maintaining self-tolerance. In addition, T cells can suppress anticancer immunity, thereby hindering protective immunosurveillance of neoplasia and hampering effective antitumour immune responses in tumour-bearing hosts, thus promoting tumour development and progression. Identification of the factors that are specifically expressed in T cells and/or that influence T cell homeostasis and function is important to understanding cancer pathogenesis and to identifying therapeutic targets. Read More

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http://dx.doi.org/10.1038/s41571-019-0175-7DOI Listing
January 2019

Mutation and clonal selection in the ageing oesophagus.

Authors:
Hugh Thomas

Nat Rev Gastroenterol Hepatol 2019 Mar;16(3):139

Nature Reviews Gastroenterology & Hepatology, .

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http://www.nature.com/articles/s41575-019-0117-y
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http://dx.doi.org/10.1038/s41575-019-0117-yDOI Listing
March 2019
7 Reads

Gut microbiota-mediated liver inflammation in PSC.

Authors:
Iain Dickson

Nat Rev Gastroenterol Hepatol 2019 Mar;16(3):140-141

Nature Reviews Gastroenterology & Hepatology, .

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http://dx.doi.org/10.1038/s41575-019-0116-zDOI Listing

Reduction of visceral adipose tissue mass requires IL-6 signalling.

Authors:
Clemens Thoma

Nat Rev Gastroenterol Hepatol 2019 Mar;16(3):140

Nature Reviews Gastroenterology & Hepatology, .

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http://dx.doi.org/10.1038/s41575-019-0114-1DOI Listing
March 2019
1 Read

Panel of 10 serum metabolites shows promise in the non-invasive detection of advanced fibrosis.

Authors:
Clemens Thoma

Nat Rev Gastroenterol Hepatol 2019 Mar;16(3):140

Nature Reviews Gastroenterology & Hepatology, .

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http://dx.doi.org/10.1038/s41575-019-0113-2DOI Listing
March 2019
1 Read

Modified FOLFIRINOX superior to gemcitabine in resected pancreatic ductal adenocarcinoma.

Authors:
Clemens Thoma

Nat Rev Gastroenterol Hepatol 2019 Mar;16(3):140

Nature Reviews Gastroenterology & Hepatology, .

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http://dx.doi.org/10.1038/s41575-019-0112-3DOI Listing
March 2019
1 Read

Big data in IBD: a look into the future.

Nat Rev Gastroenterol Hepatol 2019 Jan 18. Epub 2019 Jan 18.

INSERM U954 and Department of Hepatogastroenterology, Nancy University Hospital, Université de Lorraine, Vandoeuvre-lès-Nancy, Nancy, France.

Big data methodologies, made possible with the increasing generation and availability of digital data and enhanced analytical capabilities, have produced new insights to improve outcomes in many disciplines. Application of big data in the health-care sector is in its early stages, although the potential for leveraging underutilized data to gain a better understanding of disease and improve quality of care is enormous. Owing to the intrinsic characteristics of inflammatory bowel disease (IBD) and the management dilemmas that it imposes, the implementation of big data research strategies not only can complement current research efforts but also could represent the only way to disentangle the complexity of the disease. Read More

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http://dx.doi.org/10.1038/s41575-019-0102-5DOI Listing
January 2019
2 Reads

Better end points needed in primary sclerosing cholangitis trials.

Nat Rev Gastroenterol Hepatol 2019 Mar;16(3):143-144

Division of Gastroenterology and Center for Autoimmune Liver Diseases, San Gerardo Hospital, Department of Medicine and Surgery, University of Milano-Bicocca, Monza, Italy.

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http://dx.doi.org/10.1038/s41575-019-0110-5DOI Listing
March 2019
2 Reads

Alcohol, liver disease and the gut microbiota.

Authors:
Jasmohan S Bajaj

Nat Rev Gastroenterol Hepatol 2019 Apr;16(4):235-246

Division of Gastroenterology, Hepatology and Nutrition, Virginia Commonwealth University and McGuire VA Medical Center, Richmond, VA, USA.

Alcoholic liver disease, which ranges from mild disease to alcoholic hepatitis and cirrhosis, is a leading cause of morbidity and mortality worldwide. Alcohol intake can lead to changes in gut microbiota composition, even before liver disease development. These alterations worsen with advancing disease and could be complicit in disease progression. Read More

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http://dx.doi.org/10.1038/s41575-018-0099-1DOI Listing
April 2019
14 Reads

Preventing brain damage in necrotizing enterocolitis.

Authors:
Clemens Thoma

Nat Rev Gastroenterol Hepatol 2019 Feb;16(2):75

Nature Reviews Gastroenterology & Hepatology, .

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http://dx.doi.org/10.1038/s41575-019-0107-0DOI Listing
February 2019
1 Read

Prucalopride before surgery alleviates postoperative ileus.

Authors:
Hugh Thomas

Nat Rev Gastroenterol Hepatol 2019 Feb;16(2):76

Nature Reviews Gastroenterology & Hepatology, .

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http://dx.doi.org/10.1038/s41575-019-0106-1DOI Listing
February 2019
1 Read

Coeliac disease.

Nat Rev Dis Primers 2019 Jan 10;5(1). Epub 2019 Jan 10.

Department of Internal Medicine, Tampere University Hospital and Faculty of Medicine and Life Sciences, University of Tampere, Tampere, Finland.

Coeliac disease is an immune-mediated enteropathy against dietary gluten present in wheat, rye and barley and is one of the most common lifelong food-related disorders worldwide. Coeliac disease is also considered to be a systemic disorder characterized by a variable combination of gluten-related signs and symptoms and disease-specific antibodies in addition to enteropathy. The ingestion of gluten leads to the generation of harmful gluten peptides, which, in predisposed individuals, can induce adaptive and innate immune responses. Read More

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http://www.nature.com/articles/s41572-018-0054-z
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January 2019
15 Reads

Fungal dysbiosis associated with colorectal cancer.

Authors:
Iain Dickson

Nat Rev Gastroenterol Hepatol 2019 Feb;16(2):76

Nature Reviews Gastroenterology & Hepatology, .

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http://dx.doi.org/10.1038/s41575-019-0105-2DOI Listing
February 2019
1 Read

Probiotics fail to improve preschool gastroenteritis.

Authors:
Iain Dickson

Nat Rev Gastroenterol Hepatol 2019 Feb;16(2):76

Nature Reviews Gastroenterology & Hepatology, .

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http://dx.doi.org/10.1038/s41575-019-0104-3DOI Listing
February 2019
1 Read

No risk reduction of colorectal adenoma with aspirin or eicosapentaenoic acid.

Authors:
Iain Dickson

Nat Rev Gastroenterol Hepatol 2019 Feb;16(2):76

Nature Reviews Gastroenterology & Hepatology, .

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http://dx.doi.org/10.1038/s41575-019-0103-4DOI Listing
February 2019
1 Read

Novel connections and precision approaches.

Nat Rev Immunol 2019 Feb;19(2):75-76

Joan and Sanford I. Weill Department of Medicine, Division of Gastroenterology, Department of Microbiology and Immunology, and the Jill Roberts Institute for Research in Inflammatory Bowel Disease, Weill Cornell Medicine, Cornell University, New York, NY, USA.

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http://www.nature.com/articles/s41577-018-0114-3
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February 2019
11 Reads

A spotlight on pathogenesis, interactions and novel therapeutic options in NAFLD.

Nat Rev Gastroenterol Hepatol 2019 Feb;16(2):80-82

Division of Gastroenterology, Department of Medical Sciences, University of Turin, Turin, Italy.

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http://dx.doi.org/10.1038/s41575-018-0094-6DOI Listing
February 2019
4 Reads

T cells tune intestinal stem cell fate.

Authors:
Clemens Thoma

Nat Rev Gastroenterol Hepatol 2019 Jan;16(1)

Nature Reviews Gastroenterology & Hepatology, .

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http://dx.doi.org/10.1038/s41575-018-0096-4DOI Listing
January 2019
1 Read

Food perception primes the liver for metabolic adaptation.

Authors:
Iain Dickson

Nat Rev Gastroenterol Hepatol 2019 Jan;16(1)

Nature Reviews Gastroenterology & Hepatology, .

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http://dx.doi.org/10.1038/s41575-018-0098-2DOI Listing
January 2019
1 Read

Fatigue in IBD: epidemiology, pathophysiology and management.

Nat Rev Gastroenterol Hepatol 2019 Apr;16(4):247-259

Division of Gastroenterology, Massachusetts General Hospital, Boston, MA, USA.

Fatigue is an important clinical problem in patients with IBD, affecting nearly 50% of patients in clinical remission and > 80% of those with active disease. The resulting decrease in quality of life and impaired work productivity and functioning contribute markedly to the societal costs of fatigue. However, despite the burden and effects of fatigue, little is known about its aetiology and pathophysiology, which impairs our ability to effectively treat this symptom. Read More

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http://www.nature.com/articles/s41575-018-0091-9
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April 2019
11 Reads

Updates on hepatic homeostasis and the many tiers of hepatobiliary repair.

Nat Rev Gastroenterol Hepatol 2019 Feb;16(2):84-86

Division of Experimental Pathology, Department of Pathology, University of Pittsburgh School of Medicine, Pittsburgh, PA, USA.

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http://dx.doi.org/10.1038/s41575-018-0090-xDOI Listing
February 2019
1 Read

FMT for drug-induced colitis.

Authors:
Hugh Thomas

Nat Rev Gastroenterol Hepatol 2019 Jan;16(1)

Nature Reviews Gastroenterology & Hepatology, .

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http://www.nature.com/articles/s41575-018-0092-8
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January 2019
20 Reads

Global epidemiology and holistic prevention of pancreatitis.

Nat Rev Gastroenterol Hepatol 2019 Mar;16(3):175-184

Division of Gastroenterology & Hepatology, University of Pittsburgh Medical Center, Pittsburgh, PA, USA.

Knowledge of pancreatitis in the 20th century was shaped predominantly by animal data and clinical trials. Several large general population-based cohort studies and comprehensive systematic literature reviews in the 21st century have had a major effect on our understanding of pancreatitis and its sequelae. This Review provides precise and up-to-date data on the burden of acute pancreatitis, chronic pancreatitis and post-pancreatitis diabetes mellitus. Read More

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http://www.nature.com/articles/s41575-018-0087-5
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March 2019
28 Reads

The role of macrophages in nonalcoholic fatty liver disease and nonalcoholic steatohepatitis.

Nat Rev Gastroenterol Hepatol 2019 Mar;16(3):145-159

Department of Hepatology and Gastroenterology, Aarhus University Hospital, Aarhus, Denmark.

Nonalcoholic fatty liver disease (NAFLD) and its inflammatory and often progressive subtype nonalcoholic steatohepatitis (NASH) are becoming the leading cause of liver-related morbidity and mortality worldwide, and a primary indication for liver transplantation. The pathophysiology of NASH is multifactorial and not yet completely understood; however, innate immunity is a major contributing factor in which liver-resident macrophages (Kupffer cells) and recruited macrophages play a central part in disease progression. In this Review, we assess the evidence for macrophage involvement in the development of steatosis, inflammation and fibrosis in NASH. Read More

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http://dx.doi.org/10.1038/s41575-018-0082-xDOI Listing
March 2019
6 Reads

IL-12, IL-23 and IL-17 in IBD: immunobiology and therapeutic targeting.

Nat Rev Gastroenterol Hepatol 2019 Mar;16(3):185-196

Department of Gastroenterology, Addenbrooke's Hospital, Cambridge University Hospitals NHS Foundation Trust, Cambridge, UK.

IL-12 and IL-23 are closely related cytokines with important roles in the regulation of tissue inflammation. Converging evidence from studies in mice, human observational studies and population genetics supports the importance of these cytokines in the regulation of mucosal inflammation in the gut in particular. Ustekinumab, a therapeutic antibody targeting both cytokines is now widely licensed for the treatment of Crohn's disease, including in Europe, the USA, Canada and Japan, whilst agents targeting IL-23 specifically are in late-phase clinical trials. Read More

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http://www.nature.com/articles/s41575-018-0084-8
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March 2019
5 Reads