Search Our Scientific Publications & Authors

Nat Rev Endocrinol 2019 Feb 19. Epub 2019 Feb 19.

Nature Reviews Endocrinology, .

Nat Rev Endocrinol 2019 Feb 18. Epub 2019 Feb 18.

Associate Editor, Nature Communications, .

Nat Rev Endocrinol 2019 Feb 18. Epub 2019 Feb 18.

NeuRA, University of New South Wales, Sydney, Australia.

Nat Rev Endocrinol 2019 Feb 15. Epub 2019 Feb 15.

Nature Reviews Endocrinology, .

Nat Rev Endocrinol 2019 Feb 14. Epub 2019 Feb 14.

Nature Reviews Endocrinology, .

Nat Rev Endocrinol 2019 Feb 13. Epub 2019 Feb 13.

Institute of Metabolic Science, Addenbrooke's Hospital, Cambridge, UK.

Gut hormones have many key roles in the control of metabolism, as they target diverse tissues involved in the control of intestinal function, insulin secretion, nutrient assimilation and food intake. Produced by scattered cells found along the length of the intestinal epithelium, gut hormones generate signals related to the rate of nutrient absorption, the composition of the luminal milieu and the integrity of the epithelial barrier. Gut hormones already form the basis for existing and developing therapeutics for type 2 diabetes mellitus and obesity, exemplified by the licensed glucagon-like peptide 1 (GLP1) mimetics and dipeptidyl peptidase inhibitors that enhance GLP1 receptor activation. Read More

Nat Rev Endocrinol 2019 Feb 8. Epub 2019 Feb 8.

Nature Reviews Endocrinology, .

Nat Rev Endocrinol 2019 Feb 7. Epub 2019 Feb 7.

Program in Molecular Medicine, University of Massachusetts Medical School, Worcester, MA, USA.

Adipose tissue comprises adipocytes and many other cell types that engage in dynamic crosstalk in a highly innervated and vascularized tissue matrix. Although adipose tissue has been studied for decades, it has been appreciated only in the past 5 years that extensive arborization of nerve fibres has a dominant role in regulating the function of adipose tissue. This Review summarizes the latest literature, which suggests that adipocytes signal to local sensory nerve fibres in response to perturbations in lipolysis and lipogenesis. Read More

Nat Rev Endocrinol 2019 Feb 4. Epub 2019 Feb 4.

Division of Sleep Medicine, Harvard Medical School, Boston, MA, USA.

Nat Rev Endocrinol 2019 Feb 1. Epub 2019 Feb 1.

Nature Reviews Endocrinology, .

Nat Rev Endocrinol 2019 Mar;15(3):130

Nature Reviews Endocrinology, .

Nat Rev Endocrinol 2019 Mar;15(3):130

Nature Reviews Endocrinology, .

Nat Rev Endocrinol 2019 Mar;15(3):135-137

Section on Ethnicity and Health, Diabetes, Endocrinology and Obesity Branch, National Institute of Diabetes, Digestive and Kidney Diseases, National Institutes of Health, Bethesda, MD, USA.

Nat Rev Endocrinol 2019 Mar;15(3):129

Nature Reviews Endocrinology, .

Nat Rev Endocrinol 2019 Jan 23. Epub 2019 Jan 23.

Translational Research in Gastrointestinal Disorders (TARGID), Department of Chronic Diseases, Metabolism and Ageing (CHROMETA), KU Leuven, Leuven, Belgium.

After the discovery of motilin in 1972, motilin and the motilin receptor were studied intensely for their role in the control of gastrointestinal motility and as targets for treating hypomotility disorders. The genetic revolution - with the use of knockout models - sparked novel insights into the role of multiple peptides but contributed to a decline in interest in motilin, as this peptide and its receptor exist only as pseudogenes in rodents. The past 5 years have seen a major surge in interest in motilin, as a series of studies have shown its relevance in the control of hunger and regulation of food intake in humans in both health and disease. Read More

Nat Rev Endocrinol 2019 Jan 22. Epub 2019 Jan 22.

Department of Human Biology, NUTRIM School of Nutrition and Translational Research in Metabolism, Maastricht University Medical Centre+, Maastricht, Netherlands.

Evidence is accumulating that the gut microbiome is involved in the aetiology of obesity and obesity-related complications such as nonalcoholic fatty liver disease (NAFLD), insulin resistance and type 2 diabetes mellitus (T2DM). The gut microbiota is able to ferment indigestible carbohydrates (for example, dietary fibre), thereby yielding important metabolites such as short-chain fatty acids and succinate. Numerous animal studies and a handful of human studies suggest a beneficial role of these metabolites in the prevention and treatment of obesity and its comorbidities. Read More

Nat Rev Endocrinol 2019 Mar;15(3):132-133

Cancer Immunology and Immunotherapy Group, Department of Surgery, Trinity Translational Medicine Institute, Trinity College Dublin, St James's Hospital, Dublin, Ireland.

Nat Rev Endocrinol 2019 Mar;15(3):128

Chief Editor, Nature Reviews Urology, .

Nat Rev Endocrinol 2019 Mar;15(3):129

Nature Reviews Endocrinology, .

Nat Rev Endocrinol 2019 Jan 17. Epub 2019 Jan 17.

Department of Physiology and Pharmacology, Karolinska Institutet, Stockholm, Sweden.

Perturbed diurnal rhythms are becoming increasingly evident as deleterious events in the pathology of metabolic diseases. Exercise is well characterized as a crucial intervention in the prevention and treatment of individuals with metabolic diseases. Little is known, however, regarding optimizing the timing of exercise bouts in order to maximize their health benefits. Read More

Nat Rev Endocrinol 2019 Jan 17. Epub 2019 Jan 17.

NUTRIM School for Nutrition and Translational Research in Metabolism, Department of Human Biology, Maastricht University, Maastricht, Netherlands.

One of the biggest challenges in the management of obesity is the prevention of weight regain after successful weight loss. Weight regain after weight loss has large interindividual variation. Although many factors probably contribute to this variation, we hypothesize that variability in biological responses associated with weight loss-induced shrinking of subcutaneous adipocytes has an important role. Read More

Nat Rev Endocrinol 2019 Mar;15(3):128

Nature Reviews Endocrinology, .

Nat Rev Endocrinol 2019 Mar;15(3):127

Associate Editor, Nature Communications, .

Nat Rev Endocrinol 2019 Mar;15(3):129

Nature Reviews Endocrinology, .

Nat Rev Endocrinol 2019 Mar;15(3):172-188

Department of Transplantation Medicine, Oslo University Hospital Rikshospitalet, Oslo, Norway.

Solid organ transplantation (SOT) is a life-saving procedure and an established treatment for patients with end-stage organ failure. However, transplantation is also accompanied by associated cardiovascular risk factors, of which post-transplant diabetes mellitus (PTDM) is one of the most important. PTDM develops in 10-20% of patients with kidney transplants and in 20-40% of patients who have undergone other SOT. Read More

Nat Rev Endocrinol 2019 Mar;15(3):131-132

Department of Medicine, Harvard Medical School, Boston, MA, USA.

Nat Rev Endocrinol 2019 Feb;15(2):126

Division of Diabetes & Metabolism, Garvan Institute of Medical Research, Darlinghurst, NSW, Australia.

In the original version of this manuscript, the incorrect names for two proteins were given. S1P and S2P should have been defined as site-1 protease and site-2 protease. This has been corrected in the HTML and PDF versions of the manuscript. Read More

Nat Rev Endocrinol 2019 Mar;15(3):134-135

Department of Surgery, University of Alberta, Edmonton, Alberta, Canada.

Nat Rev Endocrinol 2019 Feb;15(2):63

Nature Reviews Endocrinology, .

Nat Rev Endocrinol 2019 Feb;15(2):69-70

Metabolism and Nutrition Research Group, WELBIO-Walloon Excellence in Life Sciences and BIOtechnology, Louvain Drug Research Institute, UCLouvain, Université catholique de Louvain, Brussels, Belgium.

Nat Rev Endocrinol 2019 Feb;15(2):67-69

The Salk Institute for Biological Studies, La Jolla, CA, USA.

Nat Rev Endocrinol 2019 Feb;15(2):66

Nature Reviews Endocrinology, .

Nat Rev Endocrinol 2019 Feb;15(2):66

Nature Reviews Endocrinology, .

Nat Rev Endocrinol 2019 Feb;15(2):71-72

Department of Biochemistry and Molecular Genetics, College of Medicine, University of Illinois at Chicago, Chicago, IL, USA.

Nat Rev Endocrinol 2019 Feb;15(2):73-74

Division of Diabetes & Metabolism, Garvan Institute of Medical Research, Darlinghurst, NSW, Australia.

Nat Rev Endocrinol 2019 Feb;15(2):65

Nature Reviews Endocrinology, .

Nat Rev Endocrinol 2019 Feb;15(2):64

Nature Reviews Endocrinology, .

Nat Rev Endocrinol 2019 Feb;15(2):64

Associate Editor, Nature Communications, .

Nat Rev Endocrinol 2019 Feb;15(2):75-89

Department of Endocrinology and Metabolism, Amsterdam University Medical Centers, University of Amsterdam, Amsterdam, Netherlands.

Insulin resistance is a main determinant in the development of type 2 diabetes mellitus and a major cause of morbidity and mortality. The circadian timing system consists of a central brain clock in the hypothalamic suprachiasmatic nucleus and various peripheral tissue clocks. The circadian timing system is responsible for the coordination of many daily processes, including the daily rhythm in human glucose metabolism. Read More

Nat Rev Endocrinol 2019 Feb;15(2):105-125

Inserm, U1016, Institut Cochin, Paris, France.

Despite considerable advances in the past few years, obesity and type 2 diabetes mellitus (T2DM) remain two major challenges for public health systems globally. In the past 9 years, genome-wide association studies (GWAS) have established a major role for genetic variation within the MTNR1B locus in regulating fasting plasma levels of glucose and in affecting the risk of T2DM. This discovery generated a major interest in the melatonergic system, in particular the melatonin MT receptor (which is encoded by MTNR1B). Read More

Nat Rev Endocrinol 2019 Feb;15(2):65

Nature Reviews Endocrinology, .

Nat Rev Endocrinol 2019 Mar;15(3):155-171

Institute of Diabetes and Regeneration Research, Helmholtz Zentrum München, Neuherberg, Germany.

Diabetes mellitus is a multifactorial disease affecting increasing numbers of patients worldwide. Progression to insulin-dependent diabetes mellitus is characterized by the loss or dysfunction of pancreatic β-cells, but the pathomechanisms underlying β-cell failure in type 1 diabetes mellitus and type 2 diabetes mellitus are still poorly defined. Regeneration of β-cell mass from residual islet cells or replacement by β-like cells derived from stem cells holds great promise to stop or reverse disease progression. Read More

Nat Rev Endocrinol 2019 Feb;15(2):65

Nature Reviews Endocrinology, .

Nat Rev Endocrinol 2018 Dec;15(1)

Nature Reviews Endocrinology, .

Nat Rev Endocrinol 2018 Dec;15(1)

Nature Reviews Endocrinology, .

Nat Rev Endocrinol 2018 Dec;15(1)

Associate Editor, Nature Communications, .

Nat Rev Endocrinol 2018 Dec;15(1):9-20

Cancer Research Group, Departament de Bioquímica i Biomedicina Molecular, Facultat de Biologia, Universitat de Barcelona, Barcelona, Spain.

Cachexia is a systemic condition that occurs during many neoplastic diseases, such as cancer. Cachexia in cancer is characterized by loss of body weight and muscle and by adipose tissue wasting and systemic inflammation. Cancer cachexia is often associated with anorexia and increased energy expenditure. Read More

Nat Rev Endocrinol 2019 Mar;15(3):139-154

Department of Medicine, Weill Cornell Medical College, New York, NY, USA.

Obesity is associated with both increased cancer incidence and progression in multiple tumour types, and is estimated to contribute to up to 20% of cancer-related deaths. These associations are driven, in part, by metabolic and inflammatory changes in adipose tissue that disrupt physiological homeostasis both within local tissues and systemically. However, the mechanisms underlying the obesity-cancer relationship are poorly understood. Read More

Nat Rev Endocrinol 2019 Feb;15(2):90-104

Institute for Diabetes and Regeneration, Helmholtz Diabetes Center, Helmholtz Zentrum München, German Research Center for Environmental Health (GmbH), Neuherberg, Germany.

Obesity and its comorbidities, such as type 2 diabetes mellitus and cardiovascular disease, constitute growing challenges for public health and economies globally. The available treatment options for these metabolic disorders cannot reverse the disease in most individuals and have not substantially reduced disease prevalence, which underscores the unmet need for more efficacious interventions. Neurobiological resilience to energy homeostatic perturbations, combined with the heterogeneous pathophysiology of human metabolic disorders, has limited the sustainability and efficacy of current pharmacological options. Read More

Nat Rev Endocrinol 2018 Dec;15(1):5-6

Institute of Endocrinology, Sydney Children's Hospitals Network, Westmead, Sydney, Australia.