1,992 results match your criteria Nature Reviews Cardiology[Journal]


Targeting ATP citrate lyase to reduce LDL cholesterol.

Authors:
Karina Huynh

Nat Rev Cardiol 2019 Apr 16. Epub 2019 Apr 16.

Nature Reviews Cardiology, .

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http://dx.doi.org/10.1038/s41569-019-0201-6DOI Listing
April 2019
1 Read

Tricuspid valve disease: diagnosis, prognosis and management of a rapidly evolving field.

Nat Rev Cardiol 2019 Apr 15. Epub 2019 Apr 15.

Quebec Heart and Lung Institute, Laval University, Quebec City, Quebec, Canada.

Tricuspid valve disease, and particularly tricuspid regurgitation, is a highly prevalent condition with a complex pathophysiology and long-term adverse consequences. Although historically neglected, tricuspid valve disease has gained increasing recognition, with important advances in the assessment and management of this disorder over the past 2 decades. Surgical treatment remains the standard of care, but it continues to have one of the the highest death rates among all cardiac valve-related procedures, and a broad range of patients still do not receive effective therapy for tricuspid valve disease in contemporary clinical practice. Read More

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http://dx.doi.org/10.1038/s41569-019-0186-1DOI Listing
April 2019
4 Reads

Circular RNAs open a new chapter in cardiovascular biology.

Nat Rev Cardiol 2019 Apr 5. Epub 2019 Apr 5.

Department of Experimental Cardiology, Amsterdam UMC, University of Amsterdam, Amsterdam, The Netherlands.

Circular RNAs (circRNAs) are emerging as a new class of non-coding RNA molecules. This unusual class of RNA species is generated by a back-splicing event of one or two exons, resulting in a covalently closed circRNA molecule. Owing to their circular form, circRNAs are protected from degradation by exonucleases and have greater stability than linear RNA. Read More

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http://www.nature.com/articles/s41569-019-0185-2
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http://dx.doi.org/10.1038/s41569-019-0185-2DOI Listing
April 2019
3 Reads

Improved visualization of fetal heart abnormalities with 3D MRI.

Authors:
Gregory B Lim

Nat Rev Cardiol 2019 Apr 4. Epub 2019 Apr 4.

Nature Reviews Cardiology, .

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http://dx.doi.org/10.1038/s41569-019-0199-9DOI Listing

TAVR versus surgery in low-risk patients.

Authors:
Karina Huynh

Nat Rev Cardiol 2019 Apr 3. Epub 2019 Apr 3.

Nature Reviews Cardiology, .

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http://www.nature.com/articles/s41569-019-0197-y
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http://dx.doi.org/10.1038/s41569-019-0197-yDOI Listing
April 2019
2 Reads

Stratifying the effects of SGLT2i.

Nat Rev Cardiol 2019 Apr 3. Epub 2019 Apr 3.

Nature Reviews Cardiology, .

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http://www.nature.com/articles/s41569-019-0198-x
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http://dx.doi.org/10.1038/s41569-019-0198-xDOI Listing
April 2019
4 Reads

Tailoring antithrombotic strategies for high-risk AF populations.

Nat Rev Cardiol 2019 Apr 1. Epub 2019 Apr 1.

Nature Reviews Cardiology, .

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http://dx.doi.org/10.1038/s41569-019-0195-0DOI Listing
April 2019
1 Read

Lowering blood pressure in black African patients.

Authors:
Isobel Leake

Nat Rev Cardiol 2019 Apr 1. Epub 2019 Apr 1.

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http://dx.doi.org/10.1038/s41569-019-0193-2DOI Listing
April 2019
1 Read

Pushing the envelope to prevent CIED infection.

Authors:
Isobel Leake

Nat Rev Cardiol 2019 Mar 29. Epub 2019 Mar 29.

Nature Reviews Cardiology, .

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http://dx.doi.org/10.1038/s41569-019-0194-1DOI Listing
March 2019
1 Read

Novel antibody-based reversal agent for ticagrelor.

Authors:
Karina Huynh

Nat Rev Cardiol 2019 Mar 29. Epub 2019 Mar 29.

Nature Reviews Cardiology, .

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http://dx.doi.org/10.1038/s41569-019-0191-4DOI Listing
March 2019
2 Reads

Delaying cardioversion for recent-onset AF.

Authors:
Karina Huynh

Nat Rev Cardiol 2019 Mar 29. Epub 2019 Mar 29.

Nature Reviews Cardiology, .

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http://dx.doi.org/10.1038/s41569-019-0192-3DOI Listing
March 2019
1 Read

Cholesterol efflux drives stem cell expansion in hypercholesterolaemia.

Nat Rev Cardiol 2019 Mar 29. Epub 2019 Mar 29.

Nature Reviews Cardiology, .

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http://dx.doi.org/10.1038/s41569-019-0187-0DOI Listing
March 2019
1 Read

Immediate angiography does not improve outcomes after OHCA without STEMI.

Authors:
Gregory B Lim

Nat Rev Cardiol 2019 Mar 29. Epub 2019 Mar 29.

Nature Reviews Cardiology, .

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http://dx.doi.org/10.1038/s41569-019-0196-zDOI Listing
March 2019
1 Read

Eating eggs is linked to increased risk of CVD.

Authors:
Gregory B Lim

Nat Rev Cardiol 2019 Mar 28. Epub 2019 Mar 28.

Nature Reviews Cardiology, .

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http://dx.doi.org/10.1038/s41569-019-0190-5DOI Listing
March 2019
1 Read

Sonothrombolysis improves PCI after STEMI.

Authors:
Gregory B Lim

Nat Rev Cardiol 2019 Mar 28. Epub 2019 Mar 28.

Nature Reviews Cardiology, .

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http://dx.doi.org/10.1038/s41569-019-0188-zDOI Listing

Magnetically levitated LVAD gains MOMENTUM.

Authors:
Gregory B Lim

Nat Rev Cardiol 2019 Mar 28. Epub 2019 Mar 28.

Nature Reviews Cardiology, .

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http://dx.doi.org/10.1038/s41569-019-0189-yDOI Listing
March 2019
2 Reads

Resolving atherosclerosis and Alzheimer disease.

Nat Rev Cardiol 2019 May;16(5):259-260

Department of Molecular and Cellular Physiology, Albany Medical College, Albany, NY, USA.

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http://www.nature.com/articles/s41569-019-0182-5
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May 2019
9 Reads

Animal models of arrhythmia: classic electrophysiology to genetically modified large animals.

Nat Rev Cardiol 2019 Mar 20. Epub 2019 Mar 20.

Department of Medicine I, University Hospital Munich, Campus Grosshadern, Ludwig-Maximilians University Munich (LMU), Munich, Germany.

Arrhythmias are common and contribute substantially to cardiovascular morbidity and mortality. The underlying pathophysiology of arrhythmias is complex and remains incompletely understood, which explains why mostly only symptomatic therapy is available. The evaluation of the complex interplay between various cell types in the heart, including cardiomyocytes from the conduction system and the working myocardium, fibroblasts and cardiac immune cells, remains a major challenge in arrhythmia research because it can be investigated only in vivo. Read More

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http://dx.doi.org/10.1038/s41569-019-0179-0DOI Listing

Neuroimmune crosstalk in the pathophysiology of hypertension.

Nat Rev Cardiol 2019 Mar 20. Epub 2019 Mar 20.

Istituto Auxologico Italiano, IRCCS, Department of Cardiovascular, Neural and Metabolic Sciences, San Luca Hospital, Milan, Italy.

Hypertension is an important risk factor for cardiovascular morbidity and mortality and for events such as myocardial infarction, stroke, heart failure and chronic kidney disease and is a major determinant of disability-adjusted life-years. Despite the importance of hypertension, the pathogenesis of essential hypertension, which involves the complex interaction of several mechanisms, is still poorly understood. Evidence suggests that interplay between bone marrow, microglia and immune mediators underlies the development of arterial hypertension, in particular through mechanisms involving cytokines and peptides, such as neuropeptide Y, substance P, angiotensin II and angiotensin-(1-7). Read More

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http://dx.doi.org/10.1038/s41569-019-0178-1DOI Listing
March 2019
1 Read

Author Correction: Percutaneous management of paravalvular leaks.

Nat Rev Cardiol 2019 Mar 18. Epub 2019 Mar 18.

Department of Cardiology, Royal Papworth Hospital NHS Foundation Trust, Cambridge, UK.

In the version of this article initially published online, the Paravalvular Leak Device (PLD; Occlutech) was incorrectly described as having a "proximal disc that is slightly larger than the distal disc", whereas the distal disc is actually slightly larger than the proximal disc. This error has been corrected for the HTML, PDF and print versions of the article. Read More

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http://dx.doi.org/10.1038/s41569-019-0184-3DOI Listing

ACTRII signalling implicated in HF.

Authors:
Gregory B Lim

Nat Rev Cardiol 2019 May;16(5):258

Nature Reviews Cardiology, .

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http://dx.doi.org/10.1038/s41569-019-0183-4DOI Listing

Brain-heart axis in Takotsubo syndrome.

Authors:
Gregory B Lim

Nat Rev Cardiol 2019 May;16(5):258

Nature Reviews Cardiology, .

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http://dx.doi.org/10.1038/s41569-019-0181-6DOI Listing

Tailoring optogenetic tools for AF treatment.

Nat Rev Cardiol 2019 May;16(5):257

Nature Reviews Cardiology, .

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http://dx.doi.org/10.1038/s41569-019-0180-7DOI Listing

Endothelins in cardiovascular biology and therapeutics.

Nat Rev Cardiol 2019 Mar 13. Epub 2019 Mar 13.

University of Edinburgh/British Heart Foundation Centre of Research Excellence, Centre for Cardiovascular Science, Queen's Medical Research Institute, Edinburgh, UK.

Cardiovascular disease is a major contributor to global morbidity and mortality and is the common end point of many chronic diseases. The endothelins comprise three structurally similar peptides of 21 amino acids in length. Endothelin 1 (ET-1) and ET-2 activate two G protein-coupled receptors - endothelin receptor type A (ET) and endothelin receptor type B (ET) - with equal affinity, whereas ET-3 has a lower affinity for ET. Read More

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http://www.nature.com/articles/s41569-019-0176-3
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March 2019
3 Reads

Key components of a community response to out-of-hospital cardiac arrest.

Nat Rev Cardiol 2019 Mar 11. Epub 2019 Mar 11.

Department of Anesthesiology and Critical Care Medicine, The Children's Hospital of Philadelphia, University of Pennsylvania Perelman School of Medicine, Philadelphia, PA, USA.

Out-of-hospital cardiac arrest (OHCA) remains a leading cause of death worldwide, with substantial geographical, ethnic and socioeconomic disparities in outcome. Successful resuscitation efforts depend on the 'chain of survival', which includes immediate recognition of cardiac arrest and activation of the emergency response system, early bystander cardiopulmonary resuscitation (CPR) with an emphasis on chest compressions, rapid defibrillation, basic and advanced emergency medical services and integrated post-cardiac arrest care. Well-orchestrated telecommunicator CPR programmes can improve rates of bystander CPR - a critical link in the chain of survival. Read More

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http://www.nature.com/articles/s41569-019-0175-4
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March 2019
2 Reads

Inflammation and its resolution in atherosclerosis: mediators and therapeutic opportunities.

Nat Rev Cardiol 2019 Mar 7. Epub 2019 Mar 7.

Atherosclerosis Research Laboratory, Wihuri Research Institute, Helsinki, Finland.

Atherosclerosis is a lipid-driven inflammatory disease of the arterial intima in which the balance of pro-inflammatory and inflammation-resolving mechanisms dictates the final clinical outcome. Intimal infiltration and modification of plasma-derived lipoproteins and their uptake mainly by macrophages, with ensuing formation of lipid-filled foam cells, initiate atherosclerotic lesion formation, and deficient efferocytotic removal of apoptotic cells and foam cells sustains lesion progression. Defective efferocytosis, as a sign of inadequate inflammation resolution, leads to accumulation of secondarily necrotic macrophages and foam cells and the formation of an advanced lesion with a necrotic lipid core, indicative of plaque vulnerability. Read More

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http://dx.doi.org/10.1038/s41569-019-0169-2DOI Listing
March 2019
1 Read

Novel vasodilatory factor identified.

Nat Rev Cardiol 2019 May;16(5):258

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http://dx.doi.org/10.1038/s41569-019-0177-2DOI Listing
May 2019
2 Reads

Sleep reduces haematopoiesis and atherosclerosis via a neuroimmune axis.

Authors:
Gregory B Lim

Nat Rev Cardiol 2019 Apr;16(4):199

Nature Reviews Cardiology, .

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http://dx.doi.org/10.1038/s41569-019-0174-5DOI Listing

Circadian rhythms and the molecular clock in cardiovascular biology and disease.

Nat Rev Cardiol 2019 Feb 22. Epub 2019 Feb 22.

Division Heart and Lungs and Regenerative Medicine Centre, University Medical Centre Utrecht and Utrecht University, Utrecht, Netherlands.

The Earth turns on its axis every 24 h; almost all life on the planet has a mechanism - circadian rhythmicity - to anticipate the daily changes caused by this rotation. The molecular clocks that control circadian rhythms are being revealed as important regulators of physiology and disease. In humans, circadian rhythms have been studied extensively in the cardiovascular system. Read More

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http://dx.doi.org/10.1038/s41569-019-0167-4DOI Listing
February 2019
1 Read

Postoperative atrial fibrillation: mechanisms, manifestations and management.

Nat Rev Cardiol 2019 Feb 21. Epub 2019 Feb 21.

Department of Medicine and Research Center, Montreal Heart Institute and Université de Montréal, Montreal, Quebec, Canada.

Postoperative atrial fibrillation (POAF) complicates 20-40% of cardiac surgical procedures and 10-20% of non-cardiac thoracic operations. Typical features include onset at 2-4 days postoperatively, episodes that are often fleeting and a self-limited time course. Associated adverse consequences of POAF include haemodynamic instability, increased risk of stroke, lengthened hospital and intensive care unit stays and greater costs. Read More

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http://dx.doi.org/10.1038/s41569-019-0166-5DOI Listing
February 2019

T cells in the gut promote CVD and slow metabolism.

Nat Rev Cardiol 2019 Apr;16(4):201

Nature Reviews Cardiology, .

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http://dx.doi.org/10.1038/s41569-019-0173-6DOI Listing
April 2019
1 Read

IL-1 signalling in atherosclerosis.

Authors:
Gregory B Lim

Nat Rev Cardiol 2019 Apr;16(4):200

Nature Reviews Cardiology, .

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http://dx.doi.org/10.1038/s41569-019-0172-7DOI Listing
April 2019
1 Read

Statin efficacy in primary CVD prevention might diminish with patient age.

Nat Rev Cardiol 2019 Apr;16(4):200

Nature Reviews Cardiology, .

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http://dx.doi.org/10.1038/s41569-019-0171-8DOI Listing
April 2019
1 Read

T cell co-stimulation and co-inhibition in cardiovascular disease: a double-edged sword.

Nat Rev Cardiol 2019 Feb 15. Epub 2019 Feb 15.

Department of Surgery, Leiden University Medical Center, Leiden, Netherlands.

The role of inflammation in cardiovascular disease (CVD) is now widely accepted. Immune cells, including T cells, are influenced by inflammatory signals and contribute to the onset and progression of CVD. T cell activation is modulated by T cell co-stimulation and co-inhibition pathways. Read More

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http://dx.doi.org/10.1038/s41569-019-0164-7DOI Listing
February 2019
1 Read

Modulating myosin function to treat hypertrophic cardiomyopathy.

Nat Rev Cardiol 2019 Apr;16(4):201

Nature Reviews Cardiology, .

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http://dx.doi.org/10.1038/s41569-019-0170-9DOI Listing
April 2019
2 Reads

Mobilizing regulatory T cells to promote myocardial repair.

Authors:
Gregory B Lim

Nat Rev Cardiol 2019 Apr;16(4):200

Nature Reviews Cardiology, .

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http://dx.doi.org/10.1038/s41569-019-0168-3DOI Listing
April 2019
3 Reads

A new organoid model to study diabetic vasculopathy.

Nat Rev Cardiol 2019 Mar;16(3):131

Nature Reviews Cardiology, .

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http://dx.doi.org/10.1038/s41569-019-0165-6DOI Listing
March 2019
1 Read

Midkine promotes NETosis in myocarditis.

Authors:
Gregory B Lim

Nat Rev Cardiol 2019 Mar;16(3):132

Nature Reviews Cardiology, .

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http://dx.doi.org/10.1038/s41569-019-0163-8DOI Listing
March 2019
1 Read

What is 'LDL cholesterol'?

Nat Rev Cardiol 2019 Apr;16(4):197-198

Medical Research Council Integrative Epidemiology Unit at the University of Bristol, Bristol, UK.

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http://dx.doi.org/10.1038/s41569-019-0157-6DOI Listing

Poor sleep linked to atherosclerosis.

Nat Rev Cardiol 2019 Mar;16(3):132

Nature Reviews Cardiology, .

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http://dx.doi.org/10.1038/s41569-019-0162-9DOI Listing
March 2019
2 Reads

Ketone body utilization in myocardial ischaemia.

Authors:
Gregory B Lim

Nat Rev Cardiol 2019 Mar;16(3):133

Nature Reviews Cardiology, .

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http://dx.doi.org/10.1038/s41569-019-0161-xDOI Listing
March 2019
1 Read

Income volatility and increased risk of CVD.

Authors:
Gregory Lim

Nat Rev Cardiol 2019 Mar;16(3):133

Nature Reviews Cardiology, .

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http://dx.doi.org/10.1038/s41569-019-0159-4DOI Listing
March 2019
1 Read

Adding rivaroxaban to aspirin after CABG surgery.

Authors:
Gregory B Lim

Nat Rev Cardiol 2019 Mar;16(3):133

Nature Reviews Cardiology, .

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http://dx.doi.org/10.1038/s41569-019-0160-yDOI Listing
March 2019
1 Read

Mechanical regulation of gene expression in cardiac myocytes and fibroblasts.

Nat Rev Cardiol 2019 Jan 25. Epub 2019 Jan 25.

Departments of Bioengineering and Medicine, University of California San Diego, La Jolla, CA, USA.

The intact heart undergoes complex and multiscale remodelling processes in response to altered mechanical cues. Remodelling of the myocardium is regulated by a combination of myocyte and non-myocyte responses to mechanosensitive pathways, which can alter gene expression and therefore function in these cells. Cellular mechanotransduction and its downstream effects on gene expression are initially compensatory mechanisms during adaptations to the altered mechanical environment, but under prolonged and abnormal loading conditions, they can become maladaptive, leading to impaired function and cardiac pathologies. Read More

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http://dx.doi.org/10.1038/s41569-019-0155-8DOI Listing
January 2019
2 Reads

Artificial intelligence to improve the diagnosis of cardiovascular diseases.

Nat Rev Cardiol 2019 Mar;16(3):133

Nature Reviews Cardiology, .

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http://dx.doi.org/10.1038/s41569-019-0158-5DOI Listing

Oxidized phospholipids as a unifying theory for lipoprotein(a) and cardiovascular disease.

Nat Rev Cardiol 2019 May;16(5):305-318

Robarts Research Institute, Schulich School of Medicine & Dentistry, University of Western Ontario, London, Ontario, Canada.

Epidemiological and clinical studies over the past decade have firmly established that elevated plasma concentrations of lipoprotein(a) (Lp(a)) are an important, independent and probably causal risk factor for the development of cardiovascular diseases. Whereas a link between Lp(a) levels and atherosclerotic cardiovascular disease (ASCVD) has been appreciated for decades, the role of Lp(a) in calcific aortic valve disease (CAVD) and aortic stenosis has come into focus only in the past 5 years. ASCVD and CAVD are aetiologically distinct but have several risk factors in common and similar pathological processes at the cellular and molecular levels. Read More

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http://dx.doi.org/10.1038/s41569-018-0153-2DOI Listing
May 2019
1 Read

Transient receptor potential channels in cardiac health and disease.

Nat Rev Cardiol 2019 Jan 21. Epub 2019 Jan 21.

Normandie Université, UNICAEN, EA4650, Signalisation, Électrophysiologie et Imagerie des Lésions d'Ischémie-Reperfusion Myocardique, Caen, France.

Transient receptor potential (TRP) channels are nonselective cationic channels that are generally Ca permeable and have a heterogeneous expression in the heart. In the myocardium, TRP channels participate in several physiological functions, such as modulation of action potential waveform, pacemaking, conduction, inotropy, lusitropy, Ca and Mg handling, store-operated Ca entry, embryonic development, mitochondrial function and adaptive remodelling. Moreover, TRP channels are also involved in various pathological mechanisms, such as arrhythmias, ischaemia-reperfusion injuries, Ca-handling defects, fibrosis, maladaptive remodelling, inherited cardiopathies and cell death. Read More

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http://dx.doi.org/10.1038/s41569-018-0145-2DOI Listing
January 2019
3 Reads

Percutaneous management of paravalvular leaks.

Nat Rev Cardiol 2019 May;16(5):275-285

Department of Cardiology, Royal Papworth Hospital NHS Foundation Trust, Cambridge, UK.

Paravalvular leak (PVL) is a complication that occurs in 5-17% of patients after surgical prosthetic valve implantation. Whereas PVLs can be benign, some PVLs are associated with substantial morbidity and mortality. Percutaneous closure using occluders specifically designed to improve closure and reduce procedural complications has now become the first-line treatment for PVL. Read More

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http://www.nature.com/articles/s41569-018-0147-0
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May 2019
11 Reads

Clonal haematopoiesis predicts poor prognosis in heart failure.

Authors:
Gregory B Lim

Nat Rev Cardiol 2019 Mar;16(3):132

Nature Reviews Cardiology, .

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http://dx.doi.org/10.1038/s41569-019-0156-7DOI Listing
March 2019
1 Read

The lncRNA CHROME regulates cholesterol homeostasis.

Nat Rev Cardiol 2019 Feb;16(2):71

Nature Reviews Cardiology, .

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http://dx.doi.org/10.1038/s41569-018-0154-1DOI Listing
February 2019