1,962 results match your criteria Nature Reviews Cardiology[Journal]


T cells in the gut promote CVD and slow metabolism.

Nat Rev Cardiol 2019 Feb 19. Epub 2019 Feb 19.

Nature Reviews Cardiology, .

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http://dx.doi.org/10.1038/s41569-019-0173-6DOI Listing
February 2019

IL-1 signalling in atherosclerosis.

Authors:
Gregory B Lim

Nat Rev Cardiol 2019 Feb 19. Epub 2019 Feb 19.

Nature Reviews Cardiology, .

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http://dx.doi.org/10.1038/s41569-019-0172-7DOI Listing
February 2019

Statin efficacy in primary CVD prevention might diminish with patient age.

Nat Rev Cardiol 2019 Feb 19. Epub 2019 Feb 19.

Nature Reviews Cardiology, .

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http://dx.doi.org/10.1038/s41569-019-0171-8DOI Listing
February 2019

T cell co-stimulation and co-inhibition in cardiovascular disease: a double-edged sword.

Nat Rev Cardiol 2019 Feb 15. Epub 2019 Feb 15.

Department of Surgery, Leiden University Medical Center, Leiden, Netherlands.

The role of inflammation in cardiovascular disease (CVD) is now widely accepted. Immune cells, including T cells, are influenced by inflammatory signals and contribute to the onset and progression of CVD. T cell activation is modulated by T cell co-stimulation and co-inhibition pathways. Read More

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http://dx.doi.org/10.1038/s41569-019-0164-7DOI Listing
February 2019
1 Read

Modulating myosin function to treat hypertrophic cardiomyopathy.

Nat Rev Cardiol 2019 Feb 12. Epub 2019 Feb 12.

Nature Reviews Cardiology, .

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http://dx.doi.org/10.1038/s41569-019-0170-9DOI Listing
February 2019
2 Reads

Mobilizing regulatory T cells to promote myocardial repair.

Authors:
Gregory B Lim

Nat Rev Cardiol 2019 Feb 6. Epub 2019 Feb 6.

Nature Reviews Cardiology, .

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http://dx.doi.org/10.1038/s41569-019-0168-3DOI Listing
February 2019
2 Reads

A new organoid model to study diabetic vasculopathy.

Nat Rev Cardiol 2019 Mar;16(3):131

Nature Reviews Cardiology, .

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http://dx.doi.org/10.1038/s41569-019-0165-6DOI Listing
March 2019
1 Read

Midkine promotes NETosis in myocarditis.

Authors:
Gregory B Lim

Nat Rev Cardiol 2019 Mar;16(3):132

Nature Reviews Cardiology, .

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http://dx.doi.org/10.1038/s41569-019-0163-8DOI Listing
March 2019
1 Read

What is 'LDL cholesterol'?

Nat Rev Cardiol 2019 Jan 30. Epub 2019 Jan 30.

Medical Research Council Integrative Epidemiology Unit at the University of Bristol, Bristol, UK.

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http://dx.doi.org/10.1038/s41569-019-0157-6DOI Listing
January 2019

Poor sleep linked to atherosclerosis.

Nat Rev Cardiol 2019 Mar;16(3):132

Nature Reviews Cardiology, .

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http://dx.doi.org/10.1038/s41569-019-0162-9DOI Listing

Ketone body utilization in myocardial ischaemia.

Authors:
Gregory B Lim

Nat Rev Cardiol 2019 Mar;16(3):133

Nature Reviews Cardiology, .

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http://dx.doi.org/10.1038/s41569-019-0161-xDOI Listing
March 2019
1 Read

Income volatility and increased risk of CVD.

Authors:
Gregory Lim

Nat Rev Cardiol 2019 Mar;16(3):133

Nature Reviews Cardiology, .

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http://dx.doi.org/10.1038/s41569-019-0159-4DOI Listing
March 2019
1 Read

Adding rivaroxaban to aspirin after CABG surgery.

Authors:
Gregory B Lim

Nat Rev Cardiol 2019 Mar;16(3):133

Nature Reviews Cardiology, .

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http://dx.doi.org/10.1038/s41569-019-0160-yDOI Listing
March 2019
1 Read

Mechanical regulation of gene expression in cardiac myocytes and fibroblasts.

Nat Rev Cardiol 2019 Jan 25. Epub 2019 Jan 25.

Departments of Bioengineering and Medicine, University of California San Diego, La Jolla, CA, USA.

The intact heart undergoes complex and multiscale remodelling processes in response to altered mechanical cues. Remodelling of the myocardium is regulated by a combination of myocyte and non-myocyte responses to mechanosensitive pathways, which can alter gene expression and therefore function in these cells. Cellular mechanotransduction and its downstream effects on gene expression are initially compensatory mechanisms during adaptations to the altered mechanical environment, but under prolonged and abnormal loading conditions, they can become maladaptive, leading to impaired function and cardiac pathologies. Read More

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http://dx.doi.org/10.1038/s41569-019-0155-8DOI Listing
January 2019

Artificial intelligence to improve the diagnosis of cardiovascular diseases.

Nat Rev Cardiol 2019 Mar;16(3):133

Nature Reviews Cardiology, .

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http://dx.doi.org/10.1038/s41569-019-0158-5DOI Listing

Oxidized phospholipids as a unifying theory for lipoprotein(a) and cardiovascular disease.

Nat Rev Cardiol 2019 Jan 23. Epub 2019 Jan 23.

Robarts Research Institute, Schulich School of Medicine & Dentistry, University of Western Ontario, London, Ontario, Canada.

Epidemiological and clinical studies over the past decade have firmly established that elevated plasma concentrations of lipoprotein(a) (Lp(a)) are an important, independent and probably causal risk factor for the development of cardiovascular diseases. Whereas a link between Lp(a) levels and atherosclerotic cardiovascular disease (ASCVD) has been appreciated for decades, the role of Lp(a) in calcific aortic valve disease (CAVD) and aortic stenosis has come into focus only in the past 5 years. ASCVD and CAVD are aetiologically distinct but have several risk factors in common and similar pathological processes at the cellular and molecular levels. Read More

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http://dx.doi.org/10.1038/s41569-018-0153-2DOI Listing
January 2019
1 Read

Transient receptor potential channels in cardiac health and disease.

Nat Rev Cardiol 2019 Jan 21. Epub 2019 Jan 21.

Normandie Université, UNICAEN, EA4650, Signalisation, Électrophysiologie et Imagerie des Lésions d'Ischémie-Reperfusion Myocardique, Caen, France.

Transient receptor potential (TRP) channels are nonselective cationic channels that are generally Ca permeable and have a heterogeneous expression in the heart. In the myocardium, TRP channels participate in several physiological functions, such as modulation of action potential waveform, pacemaking, conduction, inotropy, lusitropy, Ca and Mg handling, store-operated Ca entry, embryonic development, mitochondrial function and adaptive remodelling. Moreover, TRP channels are also involved in various pathological mechanisms, such as arrhythmias, ischaemia-reperfusion injuries, Ca-handling defects, fibrosis, maladaptive remodelling, inherited cardiopathies and cell death. Read More

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http://dx.doi.org/10.1038/s41569-018-0145-2DOI Listing
January 2019
3 Reads

Percutaneous management of paravalvular leaks.

Nat Rev Cardiol 2019 Jan 18. Epub 2019 Jan 18.

Department of Cardiology, Royal Papworth Hospital NHS Foundation Trust, Cambridge, UK.

Paravalvular leak (PVL) is a complication that occurs in 5-17% of patients after surgical prosthetic valve implantation. Whereas PVLs can be benign, some PVLs are associated with substantial morbidity and mortality. Percutaneous closure using occluders specifically designed to improve closure and reduce procedural complications has now become the first-line treatment for PVL. Read More

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http://www.nature.com/articles/s41569-018-0147-0
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http://dx.doi.org/10.1038/s41569-018-0147-0DOI Listing
January 2019
5 Reads

Clonal haematopoiesis predicts poor prognosis in heart failure.

Authors:
Gregory B Lim

Nat Rev Cardiol 2019 Mar;16(3):132

Nature Reviews Cardiology, .

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http://dx.doi.org/10.1038/s41569-019-0156-7DOI Listing
March 2019
1 Read

The lncRNA CHROME regulates cholesterol homeostasis.

Nat Rev Cardiol 2019 Feb;16(2):71

Nature Reviews Cardiology, .

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http://dx.doi.org/10.1038/s41569-018-0154-1DOI Listing
February 2019

Breakthrough in heart xenotransplantation.

Nat Rev Cardiol 2019 Feb;16(2):69

Nature Reviews Cardiology, .

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http://dx.doi.org/10.1038/s41569-018-0151-4DOI Listing
February 2019

Decoding a major CAD risk locus.

Nat Rev Cardiol 2019 Feb;16(2):70

Nature Reviews Cardiology, .

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http://dx.doi.org/10.1038/s41569-018-0152-3DOI Listing
February 2019

Nutrient supplementation no substitute for healthy diets.

Authors:
Frank B Hu

Nat Rev Cardiol 2019 Feb;16(2):77-79

Departments of Nutrition and Epidemiology, Harvard T.H. Chan School of Public Health, Boston, MA, USA.

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http://dx.doi.org/10.1038/s41569-018-0143-4DOI Listing
February 2019

A farewell to aspirin in primary prevention?

Nat Rev Cardiol 2019 Feb;16(2):76-77

Sorbonne University, ACTION Study Group, Cardiology Institute, Pitié-Salpêtrière (AP-HP) University Hospital, Paris, France.

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http://dx.doi.org/10.1038/s41569-018-0148-zDOI Listing
February 2019
1 Read

Advancing the evidence base in interventional cardiology.

Authors:
Andreas Baumbach

Nat Rev Cardiol 2019 Feb;16(2):79-81

Queen Mary University of London and the Barts Heart Centre, West Smithfield, London, UK.

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http://dx.doi.org/10.1038/s41569-018-0142-5DOI Listing
February 2019

Informed decision-making in patients with valvular disease.

Authors:
Ottavio Alfieri

Nat Rev Cardiol 2019 Feb;16(2):81-82

Department of Cardiac Surgery, San Raffaele University Hospital, Milan, Italy.

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http://dx.doi.org/10.1038/s41569-018-0146-1DOI Listing
February 2019

From genetics to smart watches: developments in precision cardiology.

Nat Rev Cardiol 2019 Feb;16(2):72-73

Department of Biomedical Engineering and Alliance for Cardiovascular Diagnostic and Treatment Innovation, Johns Hopkins University, Baltimore, MD, USA.

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http://dx.doi.org/10.1038/s41569-018-0149-yDOI Listing
February 2019

Images of subclinical atherosclerosis incentivize cardiovascular risk reduction.

Authors:
Gregory B Lim

Nat Rev Cardiol 2019 Feb;16(2):70

Nature Reviews Cardiology, .

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http://dx.doi.org/10.1038/s41569-018-0150-5DOI Listing
February 2019

Targeting inflammation in CVD: advances and challenges.

Authors:
Kathryn J Moore

Nat Rev Cardiol 2019 Feb;16(2):74-75

Leon H. Charney Division of Cardiology, Department of Medicine, New York University School of Medicine, New York, NY, USA.

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http://dx.doi.org/10.1038/s41569-018-0144-3DOI Listing
February 2019

Fully bioresorbable vascular scaffolds: lessons learned and future directions.

Nat Rev Cardiol 2018 Dec 13. Epub 2018 Dec 13.

CVPath Institute, Gaithersburg, MD, USA.

Fully bioresorbable scaffolds (BRS) were designed to overcome the limitations of metallic drug-eluting stents, which permanently cage the vessel wall, thereby preventing normal coronary vasomotion, preclude bypass grafting and can provoke long-term foreign-body responses. Although multiple scaffolds have been or are in development, the Absorb Bioresorbable Vascular Scaffold (BVS; Abbott Vascular) was the first FDA-approved device and was widely expected to fulfil the dream of interventional cardiologists of a transient scaffold that would disappear 'when the job was done' and would not hamper further treatment options. Although early, small studies and even large, randomized trials showed beneficial outcomes up to 1 year of follow-up, longer-term results have been disappointing, with increased rates of device thrombosis and target-lesion revascularization. Read More

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http://dx.doi.org/10.1038/s41569-018-0124-7DOI Listing
December 2018

ROBO4 variants linked to congenital heart defects.

Nat Rev Cardiol 2019 Feb;16(2):70

Nature Reviews Cardiology, .

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http://www.nature.com/articles/s41569-018-0141-6
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http://dx.doi.org/10.1038/s41569-018-0141-6DOI Listing
February 2019
1 Read

Cardiovascular calcification: artificial intelligence and big data accelerate mechanistic discovery.

Nat Rev Cardiol 2018 Dec 10. Epub 2018 Dec 10.

Center for Interdisciplinary Cardiovascular Sciences, Cardiovascular Division, Brigham and Women's Hospital, Harvard Medical School, Boston, MA, USA.

Cardiovascular calcification is a health disorder with increasing prevalence and high morbidity and mortality. The only available therapeutic options for calcific vascular and valvular heart disease are invasive transcatheter procedures or surgeries that do not fully address the wide spectrum of these conditions; therefore, an urgent need exists for medical options. Cardiovascular calcification is an active process, which provides a potential opportunity for effective therapeutic targeting. Read More

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http://dx.doi.org/10.1038/s41569-018-0123-8DOI Listing
December 2018
1 Read

Benefits of renal denervation in HFrEF.

Authors:
Gregory B Lim

Nat Rev Cardiol 2019 Feb;16(2):71

Nature Reviews Cardiology, .

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http://dx.doi.org/10.1038/s41569-018-0139-0DOI Listing
February 2019

Nanotherapy for abdominal aortic aneurysm.

Authors:
Gregory B Lim

Nat Rev Cardiol 2019 Feb;16(2):71

Nature Reviews Cardiology, .

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http://dx.doi.org/10.1038/s41569-018-0138-1DOI Listing
February 2019
1 Read

Mid-term outcomes with CoreValve versus surgery.

Authors:
Gregory B Lim

Nat Rev Cardiol 2019 Feb;16(2):71

Nature Reviews Cardiology, .

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http://dx.doi.org/10.1038/s41569-018-0140-7DOI Listing
February 2019

Predictors of stent thrombosis and their implications for clinical practice.

Nat Rev Cardiol 2018 Dec 5. Epub 2018 Dec 5.

Kardiologie I, Zentrum für Kardiologie, University Medical Center Mainz and DZHK Standort Rhein-Main, Mainz, Germany.

Stent thrombosis (ST) is a rare but severe complication of coronary procedures with high mortality, high relapse rate and a very complex pathophysiology. An individual's susceptibility to ST is multifactorial and results from interactions between clinical factors, endothelial biology, hypersensitivity and/or inflammatory reactions, blood rheology, platelet reactivity, clotting factors, physical and mechanical properties of the stent and from the effects of these different factors on the fluid dynamics of blood flow. Since the introduction of stents 32 years ago, continuous improvements in our understanding of the pathophysiology of ST have triggered important advances, including new therapies, new technologies and an increased awareness of the implications of implantation techniques. Read More

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http://dx.doi.org/10.1038/s41569-018-0118-5DOI Listing
December 2018
2 Reads

Protective transcriptional repression by junctophilin 2 fragment.

Authors:
Gregory B Lim

Nat Rev Cardiol 2019 Jan;16(1)

Nature Reviews Cardiology, .

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http://dx.doi.org/10.1038/s41569-018-0130-9DOI Listing
January 2019

Long-term mortality benefit of CABG surgery over PCI in patients with diabetes mellitus.

Nat Rev Cardiol 2019 Jan;16(1)

Nature Reviews Cardiology, .

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http://dx.doi.org/10.1038/s41569-018-0137-2DOI Listing
January 2019

Endoscopic versus open vein-graft harvesting.

Nat Rev Cardiol 2019 Jan;16(1)

Nature Reviews Cardiology, .

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http://dx.doi.org/10.1038/s41569-018-0135-4DOI Listing
January 2019
9 Reads

No long-term benefit of IABP in cardiogenic shock.

Nat Rev Cardiol 2019 Jan;16(1)

Nature Reviews Cardiology, .

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http://dx.doi.org/10.1038/s41569-018-0136-3DOI Listing
January 2019
2 Reads

No benefit of methotrexate on the risk of cardiovascular events.

Nat Rev Cardiol 2019 Jan;16(1):2-3

Nature Reviews Cardiology, .

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http://dx.doi.org/10.1038/s41569-018-0133-6DOI Listing
January 2019

Dietary supplements undergo VITAL test.

Nat Rev Cardiol 2019 Jan;16(1):2-3

Nature Reviews Cardiology, .

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http://www.nature.com/articles/s41569-018-0132-7
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http://dx.doi.org/10.1038/s41569-018-0132-7DOI Listing
January 2019
3 Reads

Safety and efficacy of sacubitril─valsartan in acute heart failure.

Nat Rev Cardiol 2019 Jan;16(1)

Nature Reviews Cardiology, .

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http://dx.doi.org/10.1038/s41569-018-0134-5DOI Listing
January 2019

Dapagliflozin DECLAREd safe.

Authors:
Gregory B Lim

Nat Rev Cardiol 2019 Jan;16(1)

Nature Reviews Cardiology, .

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http://dx.doi.org/10.1038/s41569-018-0131-8DOI Listing
January 2019

Hypertriglyceridaemia - REDUCE-IT with icosapent ethyl.

Authors:
Gregory B Lim

Nat Rev Cardiol 2019 Jan;16(1)

Nature Reviews Cardiology, .

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http://www.nature.com/articles/s41569-018-0129-2
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January 2019
4 Reads

Inflammation linked to Takotsubo.

Nat Rev Cardiol 2019 Jan;16(1)

Nature Reviews Cardiology, .

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http://dx.doi.org/10.1038/s41569-018-0128-3DOI Listing
January 2019

High relapse rate after HF medication withdrawal.

Nat Rev Cardiol 2019 Jan;16(1)

Nature Reviews Cardiology, .

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http://dx.doi.org/10.1038/s41569-018-0126-5DOI Listing
January 2019

Feasibility of delaying coronary reperfusion.

Nat Rev Cardiol 2019 Jan;16(1)

Nature Reviews Cardiology, .

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http://dx.doi.org/10.1038/s41569-018-0127-4DOI Listing
January 2019

Targeting PCSK9 to reduce residual risk in ACS.

Nat Rev Cardiol 2019 Jan;16(1)

Nature Reviews Cardiology, .

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http://dx.doi.org/10.1038/s41569-018-0125-6DOI Listing
January 2019

Epidemiology of cardiovascular disease in China: current features and implications.

Nat Rev Cardiol 2018 Nov 22. Epub 2018 Nov 22.

Department of Epidemiology, Beijing Anzhen Hospital, Capital Medical University, Beijing Institute of Heart, Lung and Blood Vessel Diseases, Beijing, China.

Cardiovascular disease (CVD) is the leading cause of death in China. To develop effective and timely strategies to cope with the challenges of CVD epidemics, we need to understand the current epidemiological features of the major types of CVD and the implications of these features for the prevention and treatment of CVD. In this Review, we summarize eight important features of the epidemiology of CVD in China. Read More

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http://dx.doi.org/10.1038/s41569-018-0119-4DOI Listing
November 2018
21 Reads