519,196 results match your criteria Nature Neuroscience [Journal]
Oper Neurosurg (Hagerstown) 2018 Dec 14. Epub 2018 Dec 14.
Department of Neurosurgery, University of Miami, Jackson Memorial Hospital, Miami, Florida.
The catheter tip "granuloma" is a rare inflammatory mass that forms in about 3% of patients with an intradural catheter, most commonly from a morphine pump. It has also been seen with other narcotic pumps, narcotic-non-narcotic combinations, and baclofen pumps. Mass formation is associated with increased opioid dose and concentration. Read More
Rheumatology (Oxford) 2019 Jan;58(1):103-109
Department of Rheumatology, Leiden University Medical Center, Leiden, The Netherlands.
Objectives: To determine predictors of renal relapse and end-stage renal failure (ESRF) in patients with ANCA-associated vasculitis.
Methods: Data from four European Vasculitis Society randomized controlled trials, conducted roughly simultaneously between 15 March 1995 and 30 September 2002, was pooled to determine predictors of long-term renal outcome. The respective trial inclusion criteria covered the entire spectrum of disease severity. Read More
Hum Reprod 2018 Dec 14. Epub 2018 Dec 14.
Department of Clinical Sciences and Community Health, Università degli Studi di Milano, Via Commenda, 12, 20122 Milan, Italy.
Elagolix, an orally active non-peptidic GnRH antagonist, has been approved by the Food and Drug Administration for the management of moderate to severe pain associated with endometriosis. As the degree of ovarian suppression obtained with elagolix is dose-dependent, pain relief may be achieved by modulating the level of hypo-oestrogenism while limiting side effects. Elagolix may thus be considered a novelty in terms of its endocrine and pharmacological properties but not for its impact on the pathogenic mechanisms of endometriosis, as the target of this new drug is, yet again, alteration of the hormonal milieu. Read More
J Pediatr Psychol 2018 Dec 14. Epub 2018 Dec 14.
Oklahoma State University.
Objective: The objective of this study is to examine parent and youth appraisals of illness uncertainty as potential serial mediators in the relation between disease severity and youth depressive symptoms in adolescents with inflammatory bowel disease (IBD).
Methods: Participants were 85 adolescents 13-18 years of age (Mage = 15.75, SD =1. Read More
Clin Infect Dis 2018 Dec 14. Epub 2018 Dec 14.
Institute for Glycomics, Griffith University, Gold Coast, Australia.
Background: Neisseria gonorrhoeae and Neisseria meningitidis are closely related bacteria that cause a significant global burden of disease. Control of gonorrhoea is becoming increasingly difficult due to widespread antibiotic resistance. While vaccines are routinely used for N. Read More
Mol Phylogenet Evol 2018 Dec 11. Epub 2018 Dec 11.
CAS Key Laboratory of Mountain Ecological Restoration and Bioresource Utilization, Chengdu Institute of Biology, Chinese Academy of Sciences, P.O. Box 416, Chengdu, Sichuan 610041, China; Missouri Botanical Garden,4344 Shaw Blvd., St. Louis, Missouri 63110, U.S.A. Electronic address:
Arachniodes (Dryopteridaceae) is one of the most confusing and controversial fern genera in terms of its circumscription, nomenclature, and taxonomy. Estimates of species number range from 40 to 200. Previous molecular works included only 2-17 accessions representing 2-12 species of Arachniodes and allied genera, leaving most of the Asian species remain unsampled and the infragneric relationships unclear. Read More
Sci Total Environ 2018 Dec 3;657:517-534. Epub 2018 Dec 3.
Department of Biology & CESAM, University of Aveiro, Campus de Santiago, 3810-193 Aveiro, Portugal.
Global initiatives have been increasingly focusing on mainstreaming the values of biodiversity and ecosystem services into decision-making at all levels. Due to the accelerated rate at which biodiversity is declining and its consequences for the functioning of ecosystems and subsequently, the services they provide, there is need to develop comprehensive assessments of the services and the benefits nature delivers to society. Based on expert evaluation, we identified relevant flow linkages in the supply-side of the socio-ecological system, i. Read More
Life Sci 2018 Dec 11. Epub 2018 Dec 11.
Department of Biophysics, All India Institute of Medical Sciences, New Delhi 110029, India. Electronic address:
Aims: Idiopathic nature of male infertility disorder needs to be investigated by different horizons of molecular biology for its treatment and to device male contraceptive. Further, it can also aid in advancement of assisted reproductive technology (ART), as nowadays the failure and disquiets of ART are consistent. Herein, we have attempted to find out proteins responsible for male infertility by comparing proteome profile of sperms collected from normal control and asthenozoospermic (AS) males. Read More
Dev Biol 2018 Dec 11. Epub 2018 Dec 11.
The University of Queensland, Queensland Brain Institute, Brisbane, Queensland, 4072, Australia. Electronic address:
A neuron's contribution to the information flow within a neural circuit is governed by the structure of its dendritic arbor. The geometry of the dendritic arbor directly determines synaptic density and the size of the receptive field, both of which influence the firing pattern of the neuron. Importantly, the position of individual dendritic branches determines the identity of the neuron's presynaptic partner and thus the nature of the incoming sensory information. Read More
Chem Phys Lipids 2018 Dec 11. Epub 2018 Dec 11.
Bioinformatics Centre, Bose Institute, P-1/12 C.I.T. Scheme VII M, Kolkata, 700054, India. Electronic address:
The C-terminal helix of the Bcl-xl is known to initiate the membrane insertion of the protein by anchoring into the mitochondrial outer membrane. The C-terminal charged residues of that helix, R232, and K233, are reported to have an important structural role in the process of insertion. The present work provides a quantitative understanding of the thermodynamic contribution of these residues on the membrane insertion profile from Adaptive Biasing Force based MD simulations of 2. Read More
Antiviral Res 2018 Dec 11. Epub 2018 Dec 11.
Department of Pathology and Immunology, Washington University School of Medicine, St. Louis, MO 63110, USA.
Filoviruses, which include Ebola virus and Marburg virus, are negative-sense RNA viruses associated with sporadic outbreaks of severe viral hemorrhagic fever characterized by uncontrolled virus replication. The extreme virulence and emerging nature of these zoonotic pathogens make them a significant threat to human health. Replication of the filovirus genome and production of viral RNAs requires the function of a complex of four viral proteins, the nucleoprotein (NP), viral protein 35 (VP35), viral protein 30 (VP30) and large protein (L). Read More
Antiviral Res 2018 Dec 11. Epub 2018 Dec 11.
Friedrich-Loeffler-Institut, Federal Research Institute for Animal Health, Institute of Novel and Emerging Infectious Diseases, Greifswald-Insel Riems, Germany; German Centre for Infection Research (DZIF), Partner Site Hamburg-Luebeck-Borstel, Greifswald-Insel Riems, Germany. Electronic address:
The summer of 2018 in Germany was the second hottest and driest on record. These generally extremely favorable climatic conditions most likely triggered the further expansion and the efficient propagation of the zoonotic arthropod-borne West Nile virus in many Southern/Southeastern and even Central European countries. WNV infections were detected for the first time in resident wild and aviary birds, such as common blackbirds, northern goshawks and great grey owls in Eastern and Southeastern Germany. Read More
J Phys Chem B 2018 Dec 14. Epub 2018 Dec 14.
The drying and crystallisation of solution droplets is a problem of broad relevance, determining the micro-structures of particles formed in spray drying, the phase of particles delivered by, for example, aerosol formulations for inhalation therapies, and the impact of aerosols on radiative forcing and climate. The ephemeral nature of free-droplets, particularly when considering the drying kinetics of droplets with highly volatile constituents, has often precluded the accurate measurement of transient properties such as droplet size and composition, preventing the robust assessment of predictive models of droplet drying rates, nucleation and crystallisation. Here, we report novel measurements of the drying kinetics of individual aqueous sodium chloride solution droplets using a comparative-kinetics electrodynamic balance to isolate and trap single aerosol droplets (radius ~ 25 µm). Read More
PLoS One 2018 14;13(12):e0209091. Epub 2018 Dec 14.
Natural History Museum, University of Oslo, Oslo, Norway.
Background And Aims: The bacterial leaf nodule symbiosis is a close interaction between endophytes and their plant hosts, mainly within the coffee family. The interaction between Rubiaceae species and Burkholderia bacteria is unique due to its obligate nature, high specificity, and predominantly vertical transmission of the endophytes to the next generation of host plants. This vertical transmission is intriguing since it is the basis for the uniqueness of the symbiosis. Read More
J Exp Psychol Gen 2018 Dec 13. Epub 2018 Dec 13.
Department of Psychology.
False memories are well-established long-term memory (LTM) phenomena. Recent reports of false recognition at short term suggest that working memory (WM) could also give rise to false memories, supporting the unitary view of memory. Alternatively, we hypothesized that the emergence of false memories at short term results from the impairment of WM maintenance, memory performance relying then on LTM. Read More
J Exp Psychol Gen 2018 Dec 13. Epub 2018 Dec 13.
UMR CNRS 8240.
Building on the old adage that the deliberate mind corrects the emotional heart, the influential dual process model of moral cognition has posited that utilitarian responding to moral dilemmas (i.e., choosing the greater good) requires deliberate correction of an intuitive deontological response. Read More
J Appl Psychol 2018 Dec 13. Epub 2018 Dec 13.
Department of Educational Psychology.
Growing evidence on the predictive validity of vocational interests for job performance calls for greater consideration of interest assessment in organizations. However, a consensus on the fundamental dimensions of interests that are aligned with the contemporary world of work is still lacking. In the current research, we developed an organizing framework of vocational interests and empirically validated an 8-dimension model (SETPOINT: Health Science, Creative xpression, echnology, eople, rganization, nfluence, ature, and hings). Read More
Inorg Chem 2018 Dec 14. Epub 2018 Dec 14.
College of Chemistry and Materials Science , Jinan University , Guangzhou 510632 , People's Republic of China.
Three CuPz-based isostructural complexes (CuL)(CuX) (labeled as 1-ClO, 1-NO, and 1-Br, where X = ClO, NO, and Br, respectively) were prepared by solvothermal reactions of an angular bifunctional pyridyl-pyrazole ligand, 4-(pyridin-4'-ylthio)-3,5-dimethyl-1 H-pyrazole ( HL), with Cu(ClO), Cu(NO), and CuBr, respectively. Pyrazolate (Pz) groups are highly specific to form planar trinuclear CuPz units. Two CuL units are further connected by two CuX units through N-Cu-N (Py = 4-pyridyl) bonds to form an octanuclear chairlike molecule (CuL)(CuX), which then self-assembles through intertrimeric cuprophilicity to construct chainlike supraaggregates featuring two luminophores, [CuPz] and CuPyX. Read More
J Phys Chem A 2018 Dec 14. Epub 2018 Dec 14.
New metastable crystalline forms of the supertetrahedral Al4X (X=B, C, Al, Si) solids have been computationally designed using density functional theory calculations with imposing of periodic boundary conditions. The geometric and electronic structures of the predicted new systems were calculated on the basis of the diamond lattice in which all carbon atoms are replaced by the Al4X structural units, where X is boron, carbon, aluminum and silicon atoms. The calculations showed that the dynamic stability of the Al4X crystal structures critically depends on the nature of the bridging atom X: supertetrahedral Al4C and Al4Si solidsare dynamically stable, whereas Al4B and Al4Al ones are unstable. Read More
Lin Chung Er Bi Yan Hou Tou Jing Wai Ke Za Zhi 2018 Dec;32(23):1767-1773
Department of Otolaryngology Head and Neck Surgery, Beijing Tongren Hospital, Capital Medical University, Key Laboratory of Otolaryngology Head and Neck Surgery, Ministry of Education, Beijing, 100073, China.
To analyze the imaging features of unilateral maxillary sinus nasal lesions and the selection of treatment strategies based on imaging findings for these lesions. The CT and enhanced MRI data of 64 cases of unilateral maxillary sinus and nasal lesions were selected. The imaging findings and surgery approach were observed and recorded. Read More
Lin Chung Er Bi Yan Hou Tou Jing Wai Ke Za Zhi 2018 Sep;32(18):1426-1428
Department of Otolaryngology Head and Neck Surgery, Dalian Municipal Central Hospital Affiliated of Dalian Medical University.
To analyze the characteristics of patients with benign paroxysmal positional vertigo which were spontaneously cured. A total of 1 257 patients with chief complaint of positional vertigo were included and analyzed retrospectively, in which 921 cases were diagnosed as BPPV with the diagnosis standard of Guiyang meeting, and the other 336 cases were negative in the positional test diagnosed as BPPV-spontaneously cured. The age，gender and history course of the two groups were analyzed respectively. Read More
Salud Publica Mex 2018 Sep-Oct;60(5):598-604
Departamento de Investigación sobre Tabaco, Instituto Nacional de Salud Pública. Cuernavaca, Morelos. México.
The new tobacco products that include electronic cigarettes (called "E Cig", "e-hookahs", "mods", "vape-pens"), electronic nicotine delivery systems (SEAN, Spanish acronym), similar systems without nicotine (SSSN, Spanish acronym) and alternative nicotine consumption systems (SACN, Spanish acronym), are positioned in the global market with a discourse of harm reduction and risk minimization. This manuscript summarizes the scientific evidence and presents a regulatory proposal for this technological innovation, oriented to guide the decision making of legislators, government institutions and organized civil society. The scientific evidence concludes that there is no safe tobacco product for health. Read More
Am J Med Genet A 2018 Dec 14. Epub 2018 Dec 14.
Virginia Tech Carilion Research Institute, Roanoke, Virginia.
Heterozygous loss-of-function mutations in the X-linked gene CASK are associated with mental retardation and microcephaly with pontine and cerebellar hypoplasia (MICPCH) and ophthalmological disorders including optic nerve atrophy (ONA) and optic nerve hypoplasia (ONH). Recently, we have demonstrated that CASK mice display ONH with 100% penetrance but exhibit no change in retinal lamination or structure. It is not clear if CASK loss-of-function predominantly affects retinal ganglion cells, or if other retinal cells like photoreceptors are also involved. Read More
Ecol Appl 2018 Dec 14. Epub 2018 Dec 14.
Department of Ecology, Swedish University of Agricultural Sciences, Box 7044 750 07, Uppsala, Sweden.
Before-After-Control-Impact (BACI) designs are powerful tools to derive inferences about environmental perturbations (e.g. hurricanes, restoration programs) when controlled experimental designs are unfeasible. Read More
J Leukoc Biol 2018 Dec 14. Epub 2018 Dec 14.
Department of Pharmacology, University of Michigan, Ann Arbor, Michigan, USA.
The directed migration of neutrophils to sites of injury or infection is mediated by complex networks of chemoattractant-receptor signaling cascades. The recent appreciation of neutrophils as active participants in tumor progression and metastasis has drawn attention to a number of chemokine-receptor systems that may drive their recruitment to tumors. However, the dynamic nature of the tumor microenvironment (TME) along with the phenotypic diversity among tumor-associated neutrophils (TANs) call for a more comprehensive approach to understand neutrophil trafficking to tumors. Read More
Insect Sci 2018 Dec 13. Epub 2018 Dec 13.
USDA-ARS Arid Land Agricultural Center, Maricopa, AZ, 85138, USA.
Chemosensory proteins (CSPs) are soluble carrier proteins typically characterized by a six-helix bundle structure joined by two disulfide bridges and a conserved Cys spacing pattern (C1-X -C2-X -C3-X -C4). CSPs are functionally diverse with reported roles in chemosensation, immunity, development, and resistance. To expand our molecular understanding of CSP function in plant bugs, we used recently developed transcriptomic resources for Lygus lineolaris and Lygus hesperus to identify 17 and 14 CSP-like sequences, respectively. Read More
Health Soc Care Community 2018 Dec 13. Epub 2018 Dec 13.
Psychosocial Research Centre, Department of Psychiatry, University of Melbourne, Coburg, Victoria, Australia.
Carer Peer Support Workers (CPSWs) are people who have lived experience as carers/family members of persons with a mental illness, and are employed to provide support to other carers/family members. This qualitative study aimed to explore carers' experiences within a community-based CPSW pilot program in an Australian mental health service. Semi-structured phone interviews were conducted with 20 carer participants in 2015, 5-10 months following their last contact with the service. Read More
Health Soc Care Community 2018 Dec 13. Epub 2018 Dec 13.
Division of Nursing, Midwifery and Social Work, The University of Manchester, Manchester, UK.
Most surgical wounds heal by primary intention, that is, the wound is closed with sutures, clips, or glue. However, some surgical wounds are either left open to heal from the bottom up ("healing by secondary intention") or break open partially or fully after primary closure. There is little basic knowledge about the occurrence and natural history of surgical wounds healing by secondary intention (SWHSI); therefore, the aim of this survey was to estimate the number of people with SWHSI in Slovenia, the nature of these wounds, and to investigate how they are managed. Read More
Chemistry 2018 Dec 13. Epub 2018 Dec 13.
Department of Inorganic Chemistry, University of Chemistry and Technology Prague, Technická 5, 166 28, Prague 6, Czech Republic.
Black phosphorus (BP) belongs to a group of 2D nanomaterials and nowadays attracts constantly increasing attention. Parallel to the growing utilization of BP nanomaterial increase also the requirements for the thorough comprehension of its potential impact on human and animal health. The aim of this study was to compare and discuss five assays commonly used for the cytotoxicity assessments of nanomaterials with a special focus on BP nanoparticles. Read More
Compr Physiol 2018 Dec 13;9(1):75-125. Epub 2018 Dec 13.
St. Boniface Hospital Research Centre, Department of Physiology and Pathophysiology, University of Manitoba, Winnipeg, Canada.
Cardiovascular disease leading to heart failure (HF) remains a leading cause of morbidity and mortality worldwide. Improved pharmacological and interventional coronary procedures have led to improved outcomes following acute myocardial infarction. This success has translated into an unforeseen increased incidence in HF. Read More
Biometrics 2018 Dec 14. Epub 2018 Dec 14.
Center for Statistics, I-BioStat, Universiteit Hasselt, Agoralaan 1, 3590 Diepenbeek, Belgium.
In many time-to-event studies, the event of interest is recurrent. Here, the data for each sample unit corresponds to a series of gap times between the subsequent events. Given a limited follow-up period, the last gap time might be right-censored. Read More
Small 2018 Dec 13:e1804371. Epub 2018 Dec 13.
School of Materials Science and Engineering, Nanjing University of Science and Technology, Nanjing, 210094, China.
Amorphous metal oxides (AMOs) have aroused great enthusiasm across multiple energy areas over recent years due to their unique properties, such as the intrinsic isotropy, versatility in compositions, absence of grain boundaries, defect distribution, flexible nature, etc. Here, the materials engineering of AMOs is systematically reviewed in different electrochemical applications and recent advances in understanding and developing AMO-based high-performance electrodes are highlighted. Attention is focused on the important roles that AMOs play in various energy storage and conversion technologies, such as active materials in metal-ion batteries and supercapacitors as well as active catalysts in water splitting, metal-air batteries, and fuel cells. Read More
J Basic Microbiol 2018 Dec 13. Epub 2018 Dec 13.
School of Life Sciences, Jaipur National University, Jaipur, Rajasthan, India.
A potent β-CGTase producing bacterium ND1 has been isolated from sugarcane field soil in India. The biochemical, physiologicaland phylogenetic analyses based on 16S rRNA gene suggest that the isolate belongs to Bacillus cereus group. The enzyme β-CGTase produced from isolate ND1 catalyzes production of β-cyclodextrin utilizing starch as a substrate which has diverse applications in various fields. Read More
Int J Dermatol 2018 Dec 13. Epub 2018 Dec 13.
Department of Dermatology, Mayo Clinic, Rochester, MN, USA.
Background: Tinea capitis is a common pediatric dermatophyte infection. Its main pathogen in the United States is Trichophyton tonsurans accounting for greater than 95% of the infections. Other pathogens including Trichophyton violaceum and Trichophyton soudanense are common in Africa. Read More
Ecol Lett 2018 Dec 12. Epub 2018 Dec 12.
ECNU-Alberta Joint Lab for Biodiversity Study, Tiantong National Station for Forest Ecosystem Research, East China Normal University, 200241, Shanghai.
Climate is widely recognised as an important determinant of the latitudinal diversity gradient. However, most existing studies make no distinction between direct and indirect effects of climate, which substantially hinders our understanding of how climate constrains biodiversity globally. Using data from 35 large forest plots, we test hypothesised relationships amongst climate, topography, forest structural attributes (stem abundance, tree size variation and stand basal area) and tree species richness to better understand drivers of latitudinal tree diversity patterns. Read More
Glob Chang Biol 2018 Dec 12. Epub 2018 Dec 12.
Environment Agency Austria, Vienna, Austria.
The European Union (EU) has recently published its first list of invasive alien species (IAS) of EU concern to which current legislation must apply. The list comprises species known to pose great threats to biodiversity and needs to be maintained and updated. Horizon scanning is seen as critical to identify the most threatening potential IAS that do not yet occur in Europe to be subsequently risk assessed for future listing. Read More
Adv Mater 2018 Dec 13:e1806272. Epub 2018 Dec 13.
Beijing National Laboratory for Molecular Sciences (BNLMS), CAS Research/Education Center for Excellence in Molecular Sciences, Institute of Chemistry, Chinese Academy of Sciences, Beijing, 100190, P. R. China.
The structural and interfacial stabilities of metal oxides (MOs) are key issues while facing the volumetric variation and intensive interfacial polarization in electrochemical applications, including lithium-ion batteries (LIBs), supercapacitors, and catalysts. The growth of a seamless all-carbon interfacial layer on MOs with complex dimensions is not only a scientific problem, but also a practical challenge in these fields. Here, the growth of graphdiyne under ultramild condition is successfully implemented in situ for coating MOs of complex dimensions. Read More
J Cell Biochem 2018 Dec 12. Epub 2018 Dec 12.
Reproductive Medicine Center, The First Affiliated Hospital, Anhui Medical University, Hefei, China.
STOX1 is a transcription factor that is implicated in the high prevalence of human gestational diseases. It has been studied in various types of gestational diseases using different molecular and cellular biological technologies. However, the effect and detailed mechanism of storkhead box 1 (STOX1) in recurrent spontaneous abortion (RSA) remain unknown. Read More
Int J Dermatol 2018 Dec 13. Epub 2018 Dec 13.
Department of Dermatology, Faculty of Medicine Siriraj Hospital, Mahidol University, Bangkok, Thailand.
Background: This retrospective observational study aimed to investigate the long-term safety, drug survival, and factors associated with the survival of acitretin in a real-world setting.
Methods: Data of adult patients with psoriasis who attended Siriraj Hospital between 2012 and 2017 and were treated with acitretin were reviewed. Demographic data and clinical courses were recorded. Read More
Int J Cancer 2018 Dec 13. Epub 2018 Dec 13.
Department of Hematology and Bone Marrow Transplantation, Rambam Health Care Campus, Haifa, Israel.
Hematopoietic progenitors, residing in the bone marrow (BM) niche, are supported by mesenchymal stromal cells (MSCs). Cytogenetic and molecular aberrations in these progenitors lead to acute myeloid leukemia (AML). The BM-MSC role in leukemogenesis is not fully elucidated. Read More
Acta Paediatr 2018 Dec 12. Epub 2018 Dec 12.
Department of Pediatrics and Neurosciences, University of New Mexico, Albuquerque, NM, USA.
Thank you so much for your insightful comments (1) in response to our Brief Report (2) recently published in which we discuss maternal lightning strikes during pregnancy, and the impact this can have on the developing fetus. One of the main points discussed in your letter was our choice to include data on electrical injuries during pregnancy. Due to the brief nature of this communication, the number of references we could provide was very limited. Read More
J Neurosci Res 2018 Dec 12. Epub 2018 Dec 12.
Departments of Anesthesiology and Physiology, School of Medicine, Loma Linda University, Loma Linda, California.
The objectives of this present work were to review recent developments on the role of hypoxia-inducible factor (HIF) in the survival of cells under normoxic versus hypoxic and inflammatory brain conditions. The dual nature of HIF effects appears well established, based on the accumulated evidence of HIF playing both the role of adaptive factor and mediator of cell demise. Cellular HIF responses depend on pathophysiological conditions, developmental phase, comorbidities, and administered medications. Read More
Child Care Health Dev 2018 Nov 22. Epub 2018 Nov 22.
Department of Public Health, University of Otago, Wellington, New Zealand.
Background: There is limited evidence available on the nature of children's exposure to smoking and smoking paraphernalia in private spaces (homes and cars). We aimed to evaluate the extent and nature of children's exposure to smoking in these settings using image data captured by wearable cameras.
Methods: One-hundred and sixty-eight children wore wearable cameras for 4 days that automatically took pictures every 7 s. Read More
J Ren Care 2018 Dec 12. Epub 2018 Dec 12.
University of Nottingham, Nottingham, UK.
Background: Young people with chronic kidney disease (CKD) have a number of key issues and life changes to manage while also possibly transitioning into adult care. During this time, the nature of their support networks including, social, romantic, family and health care relationships, is changing.
Objective: To explore these young people's experience and perceptions of their past, current and future relationships and support networks. Read More
Mol Genet Genomic Med 2018 Dec 11. Epub 2018 Dec 11.
Paediatric Neurology Unit, Department of Paediatrics, UZ Brussel, Brussels, Belgium.
Background: The diagnostic workup in patients with a clinical suspicion of lysosomal storage diseases (LSD) is often difficult due to the variability in the clinical phenotype. The gold standard for diagnosis of LSDs consists of enzymatic testing. However, due to the sequential nature of this methodology and inconsistent genotype-phenotype correlations of certain LSDs, finding a diagnosis can be challenging. Read More
Int J Rheum Dis 2018 Dec 11. Epub 2018 Dec 11.
Department of Clinical Immunology, Xijing Hospital, The Fourth Military Medical University, Xi'an, China.
Aims: Spondyloarthritis (SpA) is an inflammatory rheumatic disease and hip involvement often results in severe deformities and functional impairment. Magnetic resonance imaging (MRI) is a powerful imaging tool for detecting early hip lesions in SpA. The aims of this study are to apply the hip inflammation MRI scoring system (HIMRISS) in SpA patients and to evaluate its reproducibility and validity. Read More
J Integr Plant Biol 2018 Dec 11. Epub 2018 Dec 11.
Institute for Advanced Studies, Wuhan University, Wuhan 430072, China.
Polyploidy refers to two or more complete sets of chromosomes that are combined within a nucleus, and includes both autopolyploidy and allopolyploidy (Otto 2007). Polyploidy is a recurring theme in the evolutionary history of plants and it has been considered an important mechanism for speciation and also for adaptability to changing environments (Shimizu-Inatsugi et al. 2017). Read More
Glob Chang Biol 2018 Dec 11. Epub 2018 Dec 11.
Dachverband Deutscher Avifaunisten (DDA) e.V., Geschäftsstelle, Münster, Germany.
Mountain areas often hold special species communities, and they are high on the list of conservation concern. Global warming and changes in human land use, such as grazing pressure and afforestation, have been suggested to be major threats for biodiversity in the mountain areas, affecting species abundance and causing distribution shifts towards mountaintops. Population shifts towards poles and mountaintops have been documented in several areas, indicating that climate change is one of the key drivers of species' distribution changes. Read More
Glia 2018 Dec 11. Epub 2018 Dec 11.
Institute of Neuroscience, State Key Laboratory of Neuroscience, CAS Center for Excellence in Brain Science and Intelligence Technology, Chinese Academy of Sciences, Shanghai, China.
Neuroinflammation in the central nervous system (CNS) is an important subject of neuroimmunological research. Emerging evidence suggests that neuroinflammation is a key player in various neurological disorders, including neurodegenerative diseases and CNS injury. Neuroinflammation is a complex and well-orchestrated process by various groups of glial cells in CNS and peripheral immune cells. Read More
J Cell Biochem 2018 Dec 11. Epub 2018 Dec 11.
Department of Colorectal Surgery, The Third Affiliated Hospital of Nanjing University of Chinese Medicine, Nanjing, Jiangsu, China.
In this article, we aim to examine the novel effects of β-sitosterol on murine experimental colitis. β-Sitosterol significantly reduces the weight loss, colon length, and alleviated microscopic appearances of colitis induced by dextran sulfate sodium. This compound also decreases the levels of TNF-α, IL-6, and IL-1β in intestinal tissue of mice with experimental colitis in a concentration-dependent manner. Read More