4,094 results match your criteria Nature Immunology[Journal]


Mosaic nanoparticle display of diverse influenza virus hemagglutinins elicits broad B cell responses.

Nat Immunol 2019 Feb 11. Epub 2019 Feb 11.

Vaccine Research Center, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, MD, USA.

The present vaccine against influenza virus has the inevitable risk of antigenic discordance between the vaccine and the circulating strains, which diminishes vaccine efficacy. This necessitates new approaches that provide broader protection against influenza. Here we designed a vaccine using the hypervariable receptor-binding domain (RBD) of viral hemagglutinin displayed on a nanoparticle (np) able to elicit antibody responses that neutralize H1N1 influenza viruses spanning over 90 years. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1038/s41590-018-0305-xDOI Listing
February 2019

Fighting influenza through hemagglutinin diversity.

Authors:
Florian Krammer

Nat Immunol 2019 Feb 11. Epub 2019 Feb 11.

Department of Microbiology, Icahn School of Medicine at Mount Sinai, New York, NY, USA.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1038/s41590-019-0317-1DOI Listing
February 2019

Macrophages, rather than DCs, are responsible for inflammasome activity in the GM-CSF BMDC model.

Nat Immunol 2019 Feb 11. Epub 2019 Feb 11.

Department of Clinical Microbiology and Immunology, Sackler Faculty of Medicine, Tel Aviv University, Tel Aviv, Israel.

Inflammasomes are one of the most important mechanisms for innate immune defense against microbial infection but are also known to drive various inflammatory disorders via processing and release of the cytokine IL-1β. As research into the regulation and effects of inflammasomes in disease has rapidly expanded, a variety of cell types, including dendritic cells (DCs), have been suggested to be inflammasome competent. Here we describe a major fault in the widely used DC-inflammasome model of bone marrow-derived dendritic cells (BMDCs) generated with the cytokine granulocyte-macrophage colony-stimulating factor (GM-CSF). Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1038/s41590-019-0313-5DOI Listing
February 2019

Pre-birth memory.

Nat Immunol 2019 Feb 11. Epub 2019 Feb 11.

Metaorganism Immunity Section, Laboratory of Immune System Biology, National Institute of Allergy and Infectious Diseases, Bethesda, MD, USA.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1038/s41590-019-0326-0DOI Listing
February 2019

Publisher Correction: c-Maf controls immune responses by regulating disease-specific gene networks and repressing IL-2 in CD4 T cells.

Nat Immunol 2019 Feb 8. Epub 2019 Feb 8.

The Francis Crick Institute, Laboratory of Immunoregulation and Infection, London, UK.

In the version of this article initially published, the Supplementary Data file was an incorrect version. The correct version is now provided. The error has been corrected in the HTML and PDF version of the article. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1038/s41590-019-0331-3DOI Listing
February 2019
1 Read

Publisher Correction: Approaches and advances in the genetic causes of autoimmune disease and their implications.

Nat Immunol 2019 Feb 7. Epub 2019 Feb 7.

JDRF/Wellcome Diabetes and Inflammation Laboratory, Wellcome Centre for Human Genetics, Nuffield Department of Medicine, NIHR Oxford Biomedical Research Centre, University of Oxford, Oxford, UK.

In the version of this article initially published, the bibliographic information for reference 2 was incorrect in the reference list, and reference 2 was cited incorrectly at the end of the second sentence in the second paragraph ("... Read More

View Article

Download full-text PDF

Source
http://www.nature.com/articles/s41590-019-0327-z
Publisher Site
http://dx.doi.org/10.1038/s41590-019-0327-zDOI Listing
February 2019
2 Reads

Author Correction: γδ T cells producing interleukin-17A regulate adipose regulatory T cell homeostasis and thermogenesis.

Nat Immunol 2019 Feb 7. Epub 2019 Feb 7.

Division of Rheumatology, Immunology and Allergy, Brigham and Women's Hospital, Boston, MA, USA.

In the version of this article initially published, three authors (Hui-Fern Kuoy, Adam P. Uldrich and Dale. I. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1038/s41590-019-0330-4DOI Listing
February 2019

Author Correction: Progression of whole-blood transcriptional signatures from interferon-induced to neutrophil-associated patterns in severe influenza.

Nat Immunol 2019 Feb 7. Epub 2019 Feb 7.

Respiratory Infection Section, National Heart and Lung Institute, Imperial College London, London, UK.

In the version of this article initially published, a source of funding was not included in the Acknowledgements section. That section should include the following: P.J. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1038/s41590-019-0328-yDOI Listing
February 2019

Revisiting the old and learning the new of zinc in immunity.

Nat Immunol 2019 Feb 4. Epub 2019 Feb 4.

Faculty of Pharmaceutical Sciences, Tokushima Bunri University, Tokushima, Japan.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1038/s41590-019-0319-zDOI Listing
February 2019

N-myristoylation of AMPK controls T cell inflammatory function.

Authors:
David K Finlay

Nat Immunol 2019 Feb 4. Epub 2019 Feb 4.

School of Biochemistry and Immunology and School of Pharmacy and Pharmaceutical Sciences, Trinity Biomedical Sciences Institute, Trinity College Dublin, Dublin, Ireland.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1038/s41590-019-0322-4DOI Listing
February 2019

An essential role for the Zn transporter ZIP7 in B cell development.

Nat Immunol 2019 Feb 4. Epub 2019 Feb 4.

Primary Immunodeficiency Group, Institute of Cellular Medicine, Newcastle University, Newcastle upon Tyne, UK.

Despite the known importance of zinc for human immunity, molecular insights into its roles have remained limited. Here we report a novel autosomal recessive disease characterized by absent B cells, agammaglobulinemia and early onset infections in five unrelated families. The immunodeficiency results from hypomorphic mutations of SLC39A7, which encodes the endoplasmic reticulum-to-cytoplasm zinc transporter ZIP7. Read More

View Article

Download full-text PDF

Source
http://www.nature.com/articles/s41590-018-0295-8
Publisher Site
http://dx.doi.org/10.1038/s41590-018-0295-8DOI Listing
February 2019
3 Reads

N-myristoyltransferase deficiency impairs activation of kinase AMPK and promotes synovial tissue inflammation.

Nat Immunol 2019 Feb 4. Epub 2019 Feb 4.

Division of Immunology and Rheumatology, Stanford University School of Medicine, Stanford, CA, USA.

N-myristoyltransferase (NMT) attaches the fatty acid myristate to the N-terminal glycine of proteins to sort them into soluble and membrane-bound fractions. Function of the energy-sensing AMP-activated protein kinase, AMPK, is myristoylation dependent. In rheumatoid arthritis (RA), pathogenic T cells shift glucose away from adenosine tri-phosphate production toward synthetic and proliferative programs, promoting proliferation, cytokine production, and tissue invasion. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1038/s41590-018-0296-7DOI Listing
February 2019
1 Read
20.004 Impact Factor

Publisher Correction: Recent progress in broadly neutralizing antibodies to HIV.

Nat Immunol 2019 Feb 1. Epub 2019 Feb 1.

Department of Immunology and Microbiology, The Scripps Research Institute, La Jolla, CA, USA.

In the version of this article initially published, some of the references in Table 1 were incorrect. The correct references are as follows: in row 12, refs. 12,44 should be ref. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1038/s41590-019-0329-xDOI Listing
February 2019
1 Read

Publisher Correction: Get the IL-17F outta here!

Nat Immunol 2019 Feb 1. Epub 2019 Feb 1.

Janssen Immunology Research and Development, Spring House, PA, USA.

In the version of this article initially published, a word ("neutraling") in sentence 2 of paragraph 5 is incorrect. The correct phrase is ".. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1038/s41590-019-0332-2DOI Listing
February 2019

SERPINB1-mediated checkpoint of inflammatory caspase activation.

Nat Immunol 2019 Jan 28. Epub 2019 Jan 28.

Department of Molecular Microbiology and Immunology, Keck School of Medicine, University of Southern California, Los Angeles, CA, USA.

Inflammatory caspases (caspase-1, caspase-4, caspase-5 and caspase-11 (caspase-1/-4/-5/-11)) mediate host defense against microbial infections, processing pro-inflammatory cytokines and triggering pyroptosis. However, precise checkpoints are required to prevent their unsolicited activation. Here we report that serpin family B member 1 (SERPINB1) limited the activity of those caspases by suppressing their caspase-recruitment domain (CARD) oligomerization and enzymatic activation. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1038/s41590-018-0303-zDOI Listing
January 2019
1 Read

Hobit- and Blimp-1-driven CD4 tissue-resident memory T cells control chronic intestinal inflammation.

Nat Immunol 2019 Jan 28. Epub 2019 Jan 28.

Department of Medicine 1, Kussmaul Campus for Medical Research and Translational Research Center, Friedrich-Alexander-Universität (FAU) Erlangen-Nürnberg, Erlangen, Germany.

Although tissue-resident memory T cells (T cells) have been shown to regulate host protection in infectious disorders, their function in inflammatory bowel disease (IBD) remains to be investigated. Here we characterized T cells in human IBD and in experimental models of intestinal inflammation. Pro-inflammatory T cells accumulated in the mucosa of patients with IBD, and the presence of CD4CD69CD103 T cells was predictive of the development of flares. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1038/s41590-018-0298-5DOI Listing
January 2019

γδ TCR ligands: the quest to solve a 500-million-year-old mystery.

Nat Immunol 2019 Feb 21;20(2):121-128. Epub 2019 Jan 21.

Birmingham Cancer Research UK Cancer Centre, School of Cancer Sciences, University of Birmingham, Birmingham, UK.

γδ T cells have been retained as a lineage over the majority of vertebrate evolution, are able to respond to immune challenges in unique ways, and are of increasing therapeutic interest. However, one central mystery has endured: the identity of the ligands recognized by the γδ T cell antigen receptor. Here we discuss the inherent challenges in answering this question, the new opportunities provided by recent studies, and the criteria by which the field might judge success. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1038/s41590-018-0304-yDOI Listing
February 2019

Uncoupling protein 2 reprograms the tumor microenvironment to support the anti-tumor immune cycle.

Nat Immunol 2019 Feb 21;20(2):206-217. Epub 2019 Jan 21.

Department of Fundamental Oncology, University of Lausanne, Lausanne, Switzerland.

Immune checkpoint blockade therapy has shifted the paradigm for cancer treatment. However, the majority of patients lack effective responses due to insufficient T cell infiltration in tumors. Here we show that expression of mitochondrial uncoupling protein 2 (UCP2) in tumor cells determines the immunostimulatory feature of the tumor microenvironment (TME) and is positively associated with prolonged survival. Read More

View Article

Download full-text PDF

Source
http://www.nature.com/articles/s41590-018-0290-0
Publisher Site
http://dx.doi.org/10.1038/s41590-018-0290-0DOI Listing
February 2019
3 Reads

Metabolic requirements for expanding and arming a clone army.

Nat Immunol 2019 Feb;20(2):118-120

Institute of Cellular Medicine, Newcastle University, Newcastle, UK.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1038/s41590-018-0299-4DOI Listing
February 2019

Basophil-derived tumor necrosis factor can enhance survival in a sepsis model in mice.

Nat Immunol 2019 Feb 21;20(2):129-140. Epub 2019 Jan 21.

Department of Pathology, Stanford University School of Medicine, Stanford, CA, USA.

Basophils are evolutionarily conserved in vertebrates, despite their small numbers and short life span, suggesting that they have beneficial roles in maintaining health. However, these roles are not fully defined. Here we demonstrate that basophil-deficient mice exhibit reduced bacterial clearance and increased morbidity and mortality in the cecal ligation and puncture (CLP) model of sepsis. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1038/s41590-018-0288-7DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6352314PMC
February 2019
2 Reads

Vaccine sex differences.

Authors:
Zoltan Fehervari

Nat Immunol 2019 Feb;20(2):111

Nature Immunology, .

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1038/s41590-018-0310-0DOI Listing
February 2019

Regulating MAVS.

Authors:
Laurie A Dempsey

Nat Immunol 2019 Feb;20(2):111

Nature Immunology, .

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1038/s41590-018-0309-6DOI Listing
February 2019

Tissue adaptation.

Authors:
Ioana Visan

Nat Immunol 2019 Feb;20(2):111

Nature Immunology, .

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1038/s41590-018-0306-9DOI Listing
February 2019

New ligand for LAG-3.

Authors:
Ioana Visan

Nat Immunol 2019 Feb;20(2):111

Nature Immunology, .

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1038/s41590-018-0307-8DOI Listing
February 2019

Suppressing alarmins.

Authors:
Laurie A Dempsey

Nat Immunol 2019 Feb;20(2):111

Nature Immunology, .

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1038/s41590-018-0308-7DOI Listing
February 2019

Metabolic rewiring of macrophages by CpG potentiates clearance of cancer cells and overcomes tumor-expressed CD47-mediated 'don't-eat-me' signal.

Nat Immunol 2019 Jan 21. Epub 2019 Jan 21.

Abramson Cancer Center, University of Pennsylvania, Philadelphia, PA, USA.

Macrophages enforce antitumor immunity by engulfing and killing tumor cells. Although these functions are determined by a balance of stimulatory and inhibitory signals, the role of macrophage metabolism is unknown. Here, we study the capacity of macrophages to circumvent inhibitory activity mediated by CD47 on cancer cells. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1038/s41590-018-0292-yDOI Listing
January 2019
14 Reads

Memory CD4 T cells are generated in the human fetal intestine.

Nat Immunol 2019 Jan 21. Epub 2019 Jan 21.

Department of Immunohematology and Blood Transfusion, Leiden University Medical Center, Leiden, the Netherlands.

The fetus is thought to be protected from exposure to foreign antigens, yet CD45RO T cells reside in the fetal intestine. Here we combined functional assays with mass cytometry, single-cell RNA sequencing and high-throughput T cell antigen receptor (TCR) sequencing to characterize the CD4 T cell compartment in the human fetal intestine. We identified 22 CD4 T cell clusters, including naive-like, regulatory-like and memory-like subpopulations, which were confirmed and further characterized at the transcriptional level. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1038/s41590-018-0294-9DOI Listing
January 2019
2 Reads

Regulatory T cells mediate specific suppression by depleting peptide-MHC class II from dendritic cells.

Nat Immunol 2019 Feb 14;20(2):218-231. Epub 2019 Jan 14.

Laboratory of Immune System Biology, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, MD, USA.

Regulatory T cells (T cells) can activate multiple suppressive mechanisms in vitro after activation via the T cell antigen receptor, resulting in antigen-independent suppression. However, it remains unclear whether similar pathways operate in vivo. Here we found that antigen-specific T cells activated by dendritic cells (DCs) pulsed with two antigens suppressed conventional naive T cells (T cells) specific for both cognate antigens and non-cognate antigens in vitro but suppressed only T cells specific for cognate antigen in vivo. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1038/s41590-018-0280-2DOI Listing
February 2019

Thymic regulatory T cells arise via two distinct developmental programs.

Nat Immunol 2019 Feb 14;20(2):195-205. Epub 2019 Jan 14.

Center for Immunology, Masonic Cancer Center, and the Department of Laboratory Medicine and Pathology, University of Minnesota, Minneapolis, MN, USA.

The developmental programs that generate a broad repertoire of regulatory T cells (T cells) able to respond to both self antigens and non-self antigens remain unclear. Here we found that mature T cells were generated through two distinct developmental programs involving CD25 T cell progenitors (CD25 TP cells) and Foxp3 T cell progenitors (Foxp3 TP cells). CD25 TP cells showed higher rates of apoptosis and interacted with thymic self antigens with higher affinity than did Foxp3 TP cells, and had a T cell antigen receptor repertoire and transcriptome distinct from that of Foxp3 TP cells. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1038/s41590-018-0289-6DOI Listing
February 2019

Transcription factor Foxp1 regulates Foxp3 chromatin binding and coordinates regulatory T cell function.

Nat Immunol 2019 Feb 14;20(2):232-242. Epub 2019 Jan 14.

Howard Hughes Medical Institute, Memorial Sloan Kettering Cancer Center, New York, NY, USA.

Regulatory T cells (T cells), whose differentiation and function are controlled by transcription factor Foxp3, express the closely related family member Foxp1. Here we explored Foxp1 function in T cells. We found that a large number of Foxp3-bound genomic sites in T cells were occupied by Foxp1 in both T cells and conventional T cells (T cells). Read More

View Article

Download full-text PDF

Source
http://www.nature.com/articles/s41590-018-0291-z
Publisher Site
http://dx.doi.org/10.1038/s41590-018-0291-zDOI Listing
February 2019
12 Reads

A noncanonical role for the engulfment gene ELMO1 in neutrophils that promotes inflammatory arthritis.

Nat Immunol 2019 Feb 14;20(2):141-151. Epub 2019 Jan 14.

Center for Cell Clearance, Department of Microbiology, Immunology and Cancer Biology, University of Virginia, Charlottesville, VA, USA.

Rheumatoid arthritis is characterized by progressive joint inflammation and affects ~1% of the human population. We noted single-nucleotide polymorphisms (SNPs) in the apoptotic cell-engulfment genes ELMO1, DOCK2, and RAC1 linked to rheumatoid arthritis. As ELMO1 promotes cytoskeletal reorganization during engulfment, we hypothesized that ELMO1 loss would worsen inflammatory arthritis. Read More

View Article

Download full-text PDF

Source
http://www.nature.com/articles/s41590-018-0293-x
Publisher Site
http://dx.doi.org/10.1038/s41590-018-0293-xDOI Listing
February 2019
8 Reads

IL-13 secreted by ILC2s promotes the self-renewal of intestinal stem cells through circular RNA circPan3.

Nat Immunol 2019 Feb 14;20(2):183-194. Epub 2019 Jan 14.

CAS Key Laboratory of Infection and Immunity, CAS Center for Excellence in Biomacromolecules, Institute of Biophysics, Chinese Academy of Sciences, Beijing, China.

Intestinal stem cells (ISCs) are maintained by stemness signaling for precise modulation of self-renewal and differentiation under homeostasis. However, the way in which intestinal immune cells regulate the self-renewal of ISCs remains elusive. Here we found that mouse and human Lgr5 ISCs showed high expression of the immune cell-associated circular RNA circPan3 (originating from the Pan3 gene transcript). Read More

View Article

Download full-text PDF

Source
http://www.nature.com/articles/s41590-018-0297-6
Publisher Site
http://dx.doi.org/10.1038/s41590-018-0297-6DOI Listing
February 2019
14 Reads

Reference-based analysis of lung single-cell sequencing reveals a transitional profibrotic macrophage.

Nat Immunol 2019 Feb 14;20(2):163-172. Epub 2019 Jan 14.

Division of Pulmonary, Critical Care, Allergy, and Sleep Medicine, Department of Medicine, University of California, San Francisco, San Francisco, CA, USA.

Tissue fibrosis is a major cause of mortality that results from the deposition of matrix proteins by an activated mesenchyme. Macrophages accumulate in fibrosis, but the role of specific subgroups in supporting fibrogenesis has not been investigated in vivo. Here, we used single-cell RNA sequencing (scRNA-seq) to characterize the heterogeneity of macrophages in bleomycin-induced lung fibrosis in mice. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1038/s41590-018-0276-yDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6340744PMC
February 2019
1 Read

Not immune to modification.

Nat Immunol 2019 Feb;20(2):116-118

Department of Molecular & Cell Biology, The University of California, Berkeley, CA, USA.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1038/s41590-018-0301-1DOI Listing
February 2019

STIM1 moonlights as an anchor for STING.

Authors:
Jianjun Wu Nan Yan

Nat Immunol 2019 Feb;20(2):112-114

Department of Immunology, University of Texas Southwestern Medical Center, Dallas, TX, USA.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1038/s41590-018-0300-2DOI Listing
February 2019

CIRCling the wagons to protect intestinal stem cells.

Nat Immunol 2019 Feb;20(2):114-116

Department of Immunology, School of Medicine, University of Washington, Seattle, WA, USA.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1038/s41590-018-0302-0DOI Listing
February 2019

The Ca sensor STIM1 regulates the type I interferon response by retaining the signaling adaptor STING at the endoplasmic reticulum.

Nat Immunol 2019 Feb 14;20(2):152-162. Epub 2019 Jan 14.

Department of Physiology, David Geffen School of Medicine, UCLA, Los Angeles, CA, USA.

Stimulator of interferon genes (STING) is an endoplasmic reticulum (ER) signaling adaptor that is essential for the type I interferon response to DNA pathogens. Aberrant activation of STING is linked to the pathology of autoimmune and autoinflammatory diseases. The rate-limiting step for the activation of STING is its translocation from the ER to the ER-Golgi intermediate compartment. Read More

View Article

Download full-text PDF

Source
http://www.nature.com/articles/s41590-018-0287-8
Publisher Site
http://dx.doi.org/10.1038/s41590-018-0287-8DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6340781PMC
February 2019
3 Reads
20.004 Impact Factor

Publisher Correction: m6A modification controls the innate immune response to infection by targeting type I interferons.

Nat Immunol 2019 Feb;20(2):243

Department of Molecular Genetics, Weizmann Institute of Science, Rehovot, Israel.

In the version of this article initially published, the penultimate sentence of the abstract included a typographical error ('cxgenes'). The correct word is 'genes'. The error has been corrected in the HTML and PDF version of the article. Read More

View Article

Download full-text PDF

Source
http://www.nature.com/articles/s41590-019-0314-4
Publisher Site
http://dx.doi.org/10.1038/s41590-019-0314-4DOI Listing
February 2019
6 Reads

mA modification controls the innate immune response to infection by targeting type I interferons.

Nat Immunol 2019 Feb 17;20(2):173-182. Epub 2018 Dec 17.

Department of Molecular Genetics, Weizmann Institute of Science, Rehovot, Israel.

N-methyladenosine (mA) is the most common mRNA modification. Recent studies have revealed that depletion of mA machinery leads to alterations in the propagation of diverse viruses. These effects were proposed to be mediated through dysregulated methylation of viral RNA. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1038/s41590-018-0275-zDOI Listing
February 2019
1 Read

Self-renewing resident cardiac macrophages limit adverse remodeling following myocardial infarction.

Nat Immunol 2019 Jan 11;20(1):29-39. Epub 2018 Dec 11.

Toronto General Hospital Research Institute, University Health Network (UHN), Toronto, Canada.

Macrophages promote both injury and repair after myocardial infarction, but discriminating functions within mixed populations remains challenging. Here we used fate mapping, parabiosis and single-cell transcriptomics to demonstrate that at steady state, TIMD4LYVE1MHC-IICCR2 resident cardiac macrophages self-renew with negligible blood monocyte input. Monocytes partially replaced resident TIMD4LYVE1MHC-IICCR2 macrophages and fully replaced TIMD4LYVE1MHC-IICCR2 macrophages, revealing a hierarchy of monocyte contribution to functionally distinct macrophage subsets. Read More

View Article

Download full-text PDF

Source
http://www.nature.com/articles/s41590-018-0272-2
Publisher Site
http://dx.doi.org/10.1038/s41590-018-0272-2DOI Listing
January 2019
20 Reads
20.004 Impact Factor

G3BP1 enhances cytoplasmic DNA pattern recognition.

Nat Immunol 2019 Jan;20(1):5-7

Department of Biochemistry, Vanderbilt University School of Medicine, Nashville, TN, USA.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1038/s41590-018-0279-8DOI Listing
January 2019

DELineating resolution of inflammation.

Nat Immunol 2019 Jan;20(1):2-3

The Department of Molecular and Cellular Physiology, Albany Medical College, Albany, New York, NY, USA.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1038/s41590-018-0278-9DOI Listing
January 2019

The transcription factor c-Maf is essential for the commitment of IL-17-producing γδ T cells.

Nat Immunol 2019 Jan 10;20(1):73-85. Epub 2018 Dec 10.

Department of Immunology, Duke University Medical Center, Durham, NC, USA.

γδ T cells that produce the cytokine IL-17 (Tγδ17 cells) are innate-like mediators of immunity that undergo effector programming in the thymus. While regulators of Tγδ17 specialization restricted to various Vγ subsets are known, a commitment factor essential to all Tγδ17 cells has remained undefined. In this study, we identified the transcription factor c-Maf as a universal regulator of Tγδ17 cell differentiation and maintenance. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1038/s41590-018-0274-0DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6294311PMC
January 2019

Histone demethylase LSD1 is required for germinal center formation and BCL6-driven lymphomagenesis.

Nat Immunol 2019 Jan 10;20(1):86-96. Epub 2018 Dec 10.

Department of Medicine, Division of Hematology & Medical Oncology, Weill Cornell Medicine, New York, NY, USA.

Germinal center (GC) B cells feature repression of many gene enhancers to establish their characteristic transcriptome. Here we show that conditional deletion of Lsd1 in GCs significantly impaired GC formation, associated with failure to repress immune synapse genes linked to GC exit, which are also direct targets of the transcriptional repressor BCL6. We found that BCL6 directly binds LSD1 and recruits it primarily to intergenic and intronic enhancers. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1038/s41590-018-0273-1DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6294324PMC
January 2019
1 Read

Cas9-directed immunity.

Authors:
Zoltan Fehervari

Nat Immunol 2019 Jan;20(1)

Nature Immunology, .

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1038/s41590-018-0285-xDOI Listing
January 2019

Blood-brain barrier integrity.

Authors:
Zoltan Fehervari

Nat Immunol 2019 Jan;20(1)

Nature Immunology, .

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1038/s41590-018-0286-9DOI Listing
January 2019

Mst kinase roles.

Authors:
Laurie A Dempsey

Nat Immunol 2019 Jan;20(1)

Nature Immunology, .

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1038/s41590-018-0284-yDOI Listing
January 2019

cDC1 cross-priming.

Authors:
Laurie A Dempsey

Nat Immunol 2019 Jan;20(1)

Nature Immunology, .

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1038/s41590-018-0283-zDOI Listing
January 2019
1 Read

Stem cell-immune cell cross-talk.

Authors:
Ioana Visan

Nat Immunol 2019 Jan;20(1)

Nature Immunology, .

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1038/s41590-018-0282-0DOI Listing
January 2019

B cells turn on, tune in with LSD1.

Nat Immunol 2019 Jan;20(1):3-5

Department of Biochemistry and Molecular Biology, and Infection and Immunity Program, Biomedicine Discovery Institute, Monash University, Clayton, Australia.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1038/s41590-018-0281-1DOI Listing
January 2019
1 Read