23,537 results match your criteria Nature Communications [Journal]


Author Correction: CHD3 helicase domain mutations cause a neurodevelopmental syndrome with macrocephaly and impaired speech and language.

Nat Commun 2019 Feb 15;10(1):883. Epub 2019 Feb 15.

CHU Sainte-Justine Research Center, Montreal, QC, H3T 1C5, Canada.

The original version of this Article contained an error in the spelling of the author Laurence Faivre, which was incorrectly given as Laurence Faive. This has now been corrected in both the PDF and HTML versions of the Article. Read More

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http://dx.doi.org/10.1038/s41467-019-08800-2DOI Listing
February 2019

On the degradation mechanisms of quantum-dot light-emitting diodes.

Nat Commun 2019 Feb 15;10(1):765. Epub 2019 Feb 15.

TCL Corporate Research, 1001 Zhongshan Park Road, Nanshan District, Shenzhen, 518067, Guangdong, China.

The operating lifetime of blue quantum-dot light-emitting diodes (QLED) is currently a short slab for this emerging display technology. To pinpoint the origin of device degradation, here we apply multiple techniques to monitor the electric-field distribution and space-charge accumulation across the multilayered structure before and after lifetime tests. Evident by charge-modulated electro-absorption and capacitance-voltage characteristics, the excited electrons in blue quantum dots (QD) are prone to cross the type II junction between the QD emission layer and the electron-transporting layer (ETL) due to the offset of conduction band minimum, leading to space-charge accumulation and operating-voltage rise in the ETL. Read More

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http://dx.doi.org/10.1038/s41467-019-08749-2DOI Listing
February 2019

Quantification of frequency-dependent genetic architectures in 25 UK Biobank traits reveals action of negative selection.

Nat Commun 2019 Feb 15;10(1):790. Epub 2019 Feb 15.

Department of Epidemiology, Harvard T.H. Chan School of Public Health, Boston, 02115, MA, USA.

Understanding the role of rare variants is important in elucidating the genetic basis of human disease. Negative selection can cause rare variants to have larger per-allele effect sizes than common variants. Here, we develop a method to estimate the minor allele frequency (MAF) dependence of SNP effect sizes. Read More

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http://dx.doi.org/10.1038/s41467-019-08424-6DOI Listing
February 2019

Amine-responsive cellulose-based ratiometric fluorescent materials for real-time and visual detection of shrimp and crab freshness.

Nat Commun 2019 Feb 15;10(1):795. Epub 2019 Feb 15.

CAS Key Laboratory of Engineering Plastics and CAS Research/Education Center for Excellence in Molecular Sciences, Chinese Academy of Sciences, 100190, Beijing, China.

Herein, we design and prepare cellulose-based ratiometric fluorescent materials with superior amine-response, which offers the real-time and visual detection of seafood freshness. Through utilizing the reactive hydroxyl groups along cellulose chains, we covalently immobilize the fluorescein isothiocyanate (FITC) as indicator and protoporphyrin IX (PpIX) as internal reference onto cellulose acetate (CA), respectively. Subsequently, a series of dual-emission solid fluorescent materials are achieved by simply blending green emitting CA-FITC with red-emitting CA-PpIX with varying ratios. Read More

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http://dx.doi.org/10.1038/s41467-019-08675-3DOI Listing
February 2019

An EDS1 heterodimer signalling surface enforces timely reprogramming of immunity genes in Arabidopsis.

Nat Commun 2019 Feb 15;10(1):772. Epub 2019 Feb 15.

Department of Plant-Microbe Interactions, Max-Planck Institute for Plant Breeding Research, Carl-von-Linne-Weg 10, 50829, Cologne, Germany.

Plant intracellular NLR receptors recognise pathogen interference to trigger immunity but how NLRs signal is not known. Enhanced disease susceptibility1 (EDS1) heterodimers are recruited by Toll-interleukin1-receptor domain NLRs (TNLs) to transcriptionally mobilise resistance pathways. By interrogating the Arabidopsis EDS1 ɑ-helical EP-domain we identify positively charged residues lining a cavity that are essential for TNL immunity signalling, beyond heterodimer formation. Read More

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http://dx.doi.org/10.1038/s41467-019-08783-0DOI Listing
February 2019

Author Correction: FGL2 promotes tumor progression in the CNS by suppressing CD103 dendritic cell differentiation.

Nat Commun 2019 Feb 15;10(1):862. Epub 2019 Feb 15.

Department of Pediatrics-Research, The University of Texas MD Anderson Cancer Center, Houston, TX, 77030, USA.

The original version of this Article contained errors in the author affiliations. Qingnan Zhao, Xueqing Xia, Longfei Huo and Shulin Li were incorrectly associated with Beijing Institute for Brain Disorders, 100069, Beijing, China.This has now been corrected in both the PDF and HTML versions of the Article. Read More

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http://dx.doi.org/10.1038/s41467-019-08770-5DOI Listing
February 2019
10.742 Impact Factor

Phenazine production promotes antibiotic tolerance and metabolic heterogeneity in Pseudomonas aeruginosa biofilms.

Nat Commun 2019 Feb 15;10(1):762. Epub 2019 Feb 15.

Department of Biological Sciences, Columbia University, New York, NY, 10027, USA.

Antibiotic efficacy can be antagonized by bioactive metabolites and other drugs present at infection sites. Pseudomonas aeruginosa, a common cause of biofilm-based infections, releases metabolites called phenazines that accept electrons to support cellular redox balancing. Here, we find that phenazines promote tolerance to clinically relevant antibiotics, such as ciprofloxacin, in P. Read More

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http://dx.doi.org/10.1038/s41467-019-08733-wDOI Listing
February 2019

Copper-catalyzed remote C(sp)-H azidation and oxidative trifluoromethylation of benzohydrazides.

Nat Commun 2019 Feb 15;10(1):769. Epub 2019 Feb 15.

Laboratory of Synthesis and Natural Products, Institute of Chemical Sciences and Engineering, Ecole Polytechnique Fédérale de Lausanne, EPFL-SB-ISIC-LSPN, BCH5304, CH-1015, Lausanne, Switzerland.

The Hofmann-Löffler-Freytag (HLF) reaction is a prototypical example of radical-based remote functionalization of unactivated C(sp)-H bond. While 1,5-hydrogen atom transfer (1,5-HAT) of the amidyl radical is thermodynamically favorable and is well-established, the method for the subsequent functionalization of the translocated carbon radical is still limited. We report herein two catalytic remote C(sp)-H functionalization protocols. Read More

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http://dx.doi.org/10.1038/s41467-019-08741-wDOI Listing
February 2019

Disulfide-mediated conversion of 8-mer bowl-like protein architecture into three different nanocages.

Nat Commun 2019 Feb 15;10(1):778. Epub 2019 Feb 15.

Beijing Advanced Innovation Center for Food Nutrition and Human Health, College of Food Science & Nutritional Engineering, China Agricultural University, Key Laboratory of Functional Dairy, Ministry of Education, 100083, Beijing, China.

Constructing different protein nanostructures with high-order discrete architectures by using one single building block remains a challenge. Here, we present a simple, effective disulfide-mediated approach to prepare a set of protein nanocages with different geometries from single building block. By genetically deleting an inherent intra-subunit disulfide bond, we can render the conversion of an 8-mer bowl-like protein architecture (NF-8) into a 24-mer ferritin-like nanocage in solution, while selective insertion of an inter-subunit disulfide bond into NF-8 triggers its conversion into a 16-mer lenticular nanocage. Read More

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http://dx.doi.org/10.1038/s41467-019-08788-9DOI Listing
February 2019

Single gametophyte sequencing reveals that crossover events differ between sexes in maize.

Nat Commun 2019 Feb 15;10(1):785. Epub 2019 Feb 15.

National Key Laboratory of Crop Genetic Improvement, Huazhong Agricultural University, Wuhan, 430070, China.

Meiotic crossover (CO) plays a key role in producing gametophytes and generating genetic variation. The patterns of CO production differ inter- and intra-species, as well as between sexes. However, sex-specific patterns of CO production have not been accurately profiled independently of genetic backgrounds in maize. Read More

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http://dx.doi.org/10.1038/s41467-019-08786-xDOI Listing
February 2019

Structural insights into chaperone addiction of toxin-antitoxin systems.

Nat Commun 2019 Feb 15;10(1):782. Epub 2019 Feb 15.

Institut de Pharmacologie et de Biologie Structurale, IPBS, Université de Toulouse, CNRS, UPS, 31077, Toulouse, France.

SecB chaperones assist protein export by binding both unfolded proteins and the SecA motor. Certain SecB homologs can also control toxin-antitoxin (TA) systems known to modulate bacterial growth in response to stress. In such TA-chaperone (TAC) systems, SecB assists the folding and prevents degradation of the antitoxin, thus facilitating toxin inhibition. Read More

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http://dx.doi.org/10.1038/s41467-019-08747-4DOI Listing
February 2019

Capturing the inherent structural dynamics of the HIV-1 envelope glycoprotein fusion peptide.

Nat Commun 2019 Feb 15;10(1):763. Epub 2019 Feb 15.

Department of Integrative Structural and Computational Biology, The Scripps Research Institute, La Jolla, CA, 92037, USA.

The N-terminal fusion peptide (FP) of the human immunodeficiency virus (HIV)-1 envelope glycoprotein (Env) gp41 subunit plays a critical role in cell entry. However, capturing the structural flexibility in the unbound FP is challenging in the native Env trimer. Here, FP conformational isomerism is observed in two crystal structures of a soluble clade B transmitted/founder virus B41 SOSIP. Read More

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http://dx.doi.org/10.1038/s41467-019-08738-5DOI Listing
February 2019

Carbon sequestration during core formation implied by complex carbon polymerization.

Nat Commun 2019 Feb 15;10(1):789. Epub 2019 Feb 15.

Department of Earth, Planetary and Space Sciences, University of California, Los Angeles, 90095, CA, USA.

Current estimates of the carbon flux between the surface and mantle are highly variable, and the total amount of carbon stored in closed hidden reservoirs is unknown. Understanding the forms in which carbon existed in the molten early Earth is a critical step towards quantifying the carbon budget of Earth's deep interior. Here we employ first-principles molecular dynamics to study the evolution of carbon species as a function of pressure in a pyrolite melt. Read More

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http://dx.doi.org/10.1038/s41467-019-08742-9DOI Listing
February 2019

A functional subset of CD8 T cells during chronic exhaustion is defined by SIRPα expression.

Nat Commun 2019 Feb 15;10(1):794. Epub 2019 Feb 15.

Laboratory of Persistent Viral Diseases, Rocky Mountain Laboratories, Hamilton, MT, 59840, USA.

Prolonged exposure of CD8 T cells to antigenic stimulation, as in chronic viral infections, leads to a state of diminished function termed exhaustion. We now demonstrate that even during exhaustion there is a subset of functional CD8 T cells defined by surface expression of SIRPα, a protein not previously reported on lymphocytes. On SIRPα CD8 T cells, expression of co-inhibitory receptors is counterbalanced by expression of co-stimulatory receptors and it is only SIRPα cells that actively proliferate, transcribe IFNγ and show cytolytic activity. Read More

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http://dx.doi.org/10.1038/s41467-019-08637-9DOI Listing
February 2019
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Resolution limit of image analysis algorithms.

Nat Commun 2019 Feb 15;10(1):793. Epub 2019 Feb 15.

Department of Biomedical Engineering, Texas A&M University, College Station, TX, 77843, USA.

The resolution of an imaging system is a key property that, despite many advances in optical imaging methods, remains difficult to define and apply. Rayleigh's and Abbe's resolution criteria were developed for observations with the human eye. However, modern imaging data is typically acquired on highly sensitive cameras and often requires complex image processing algorithms to analyze. Read More

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http://dx.doi.org/10.1038/s41467-019-08689-xDOI Listing
February 2019

A mathematical-descriptor of tumor-mesoscopic-structure from computed-tomography images annotates prognostic- and molecular-phenotypes of epithelial ovarian cancer.

Nat Commun 2019 Feb 15;10(1):764. Epub 2019 Feb 15.

Cancer Imaging Centre, Department of Surgery and Cancer, Faculty of Medicine, Imperial College London, London, W12 0HS, UK.

The five-year survival rate of epithelial ovarian cancer (EOC) is approximately 35-40% despite maximal treatment efforts, highlighting a need for stratification biomarkers for personalized treatment. Here we extract 657 quantitative mathematical descriptors from the preoperative CT images of 364 EOC patients at their initial presentation. Using machine learning, we derive a non-invasive summary-statistic of the primary ovarian tumor based on 4 descriptors, which we name "Radiomic Prognostic Vector" (RPV). Read More

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http://dx.doi.org/10.1038/s41467-019-08718-9DOI Listing
February 2019

Oxygen vacancy associated single-electron transfer for photofixation of CO to long-chain chemicals.

Nat Commun 2019 Feb 15;10(1):788. Epub 2019 Feb 15.

Hefei National Laboratory for Physical Sciences at the Microscale, Collaborative Innovation Center of Chemistry for Energy Materials, University of Science and Technology of China, Hefei, 230026, P.R. China.

The photofixation and utilization of CO via single-electron mechanism is considered to be a clean and green way to produce high-value-added commodity chemicals with long carbon chains. However, this topic has not been fully explored for the highly negative reduction potential in the formation of reactive carbonate radical. Herein, by taking BiO nanosheets as a model system, we illustrate that oxygen vacancies confined in atomic layers can lower the adsorption energy of CO on the reactive sites, and thus activate CO by single-electron transfer in mild conditions. Read More

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http://dx.doi.org/10.1038/s41467-019-08697-xDOI Listing
February 2019

Barcoding reveals complex clonal behavior in patient-derived xenografts of metastatic triple negative breast cancer.

Nat Commun 2019 Feb 15;10(1):766. Epub 2019 Feb 15.

Department of Medical Biology, The University of Melbourne, Melbourne, VIC, 3010, Australia.

Primary triple negative breast cancers (TNBC) are prone to dissemination but sub-clonal relationships between tumors and resulting metastases are poorly understood. Here we use cellular barcoding of two treatment-naïve TNBC patient-derived xenografts (PDXs) to track the spatio-temporal fate of thousands of barcoded clones in primary tumors, and their metastases. Tumor resection had a major impact on reducing clonal diversity in secondary sites, indicating that most disseminated tumor cells lacked the capacity to 'seed', hence originated from 'shedders' that did not persist. Read More

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http://dx.doi.org/10.1038/s41467-019-08595-2DOI Listing
February 2019

The short-chain fatty acid pentanoate suppresses autoimmunity by modulating the metabolic-epigenetic crosstalk in lymphocytes.

Nat Commun 2019 Feb 15;10(1):760. Epub 2019 Feb 15.

Institute for Medical Microbiology and Hygiene, Philipps-University Marburg, Marburg, 35043, Germany.

Short-chain fatty acids (SCFAs) have immunomodulatory effects, but the underlying mechanisms are not well understood. Here we show that pentanoate, a physiologically abundant SCFA, is a potent regulator of immunometabolism. Pentanoate induces IL-10 production in lymphocytes by reprogramming their metabolic activity towards elevated glucose oxidation. Read More

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http://dx.doi.org/10.1038/s41467-019-08711-2DOI Listing
February 2019

Stress-induced inactivation of the Staphylococcus aureus purine biosynthesis repressor leads to hypervirulence.

Nat Commun 2019 Feb 15;10(1):775. Epub 2019 Feb 15.

Department of Microbiology and Immunology, University of Western Ontario, London, ON, Canada, N6A 5C1.

Staphylococcus aureus is a significant cause of human infection. Here, we demonstrate that mutations in the transcriptional repressor of purine biosynthesis, purR, enhance the pathogenic potential of S. aureus. Read More

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http://dx.doi.org/10.1038/s41467-019-08724-xDOI Listing
February 2019

Multi-cohort study identifies social determinants of systemic inflammation over the life course.

Nat Commun 2019 Feb 15;10(1):773. Epub 2019 Feb 15.

LEASP, UMR 1027, Inserm-Université Toulouse III Paul Sabatier, Toulouse, 31000, France.

Chronic inflammation has been proposed as having a prominent role in the construction of social inequalities in health. Disentangling the effects of early life and adulthood social disadvantage on inflammation is key in elucidating biological mechanisms underlying socioeconomic disparities. Here we explore the relationship between socioeconomic position (SEP) across the life course and inflammation (as measured by CRP levels) in up to 23,008 participants from six European cohort studies from three countries conducted between 1958 and 2013. Read More

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http://dx.doi.org/10.1038/s41467-019-08732-xDOI Listing
February 2019

Extortion strategies resist disciplining when higher competitiveness is rewarded with extra gain.

Nat Commun 2019 Feb 15;10(1):783. Epub 2019 Feb 15.

Department of Evolutionary Ecology, Max-Planck-Institute for Evolutionary Biology, August-Thienemann-Strasse 2, 24306, Plön, Germany.

Cooperative strategies are predicted for repeated social interactions. The recently described Zero Determinant (ZD) strategies enforce the partner's cooperation because the 'generous' ZD players help their cooperative partners while 'extortionate' ZD players exploit their partners' cooperation. Partners may accede to extortion because it pays them to do so, but the partner can sabotage his own and his extortioner's score by defecting to discipline the extortioner. Read More

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http://dx.doi.org/10.1038/s41467-019-08671-7DOI Listing
February 2019

Stable radical anions generated from a porous perylenediimide metal-organic framework for boosting near-infrared photothermal conversion.

Nat Commun 2019 Feb 15;10(1):767. Epub 2019 Feb 15.

State Key Laboratory of Chemical Resource Engineering, Beijing Advanced Innovation Center for Soft Matter Science and Engineering, Beijing Laboratory of Biomedical Materials, Beijing University of Chemical Technology, 100029, Beijing, P. R. China.

Radical anions of electron-deficient systems are widely used, but are easily reoxidized upon exposure to air. Therefore, the stabilization of radical anions under ambient conditions is of great significance, but still remains a scientific challenge. Herein, perylenediimide is employed to prepare a crystalline metal-organic framework for stabilizing radical anions without extensive chemical modification. Read More

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http://dx.doi.org/10.1038/s41467-019-08434-4DOI Listing
February 2019

1D versus 2D cocrystals growth via microspacing in-air sublimation.

Nat Commun 2019 Feb 15;10(1):761. Epub 2019 Feb 15.

State Key Laboratory of Crystal Materials, Shandong University, 250100, Jinan, Shandong, People's Republic of China.

Organic cocrystals possess valuable properties owing to the synergistic effect of the individual components. However, the growth of molecular cocrystals is still in its primary stage. Here we develop a microspacing in-air sublimation method to grow organic cocrystals, and furthermore to realize morphology control on them, which is essential for structure-property relations. Read More

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http://dx.doi.org/10.1038/s41467-019-08712-1DOI Listing
February 2019

Highly efficient photothermal nanoagent achieved by harvesting energy via excited-state intramolecular motion within nanoparticles.

Nat Commun 2019 Feb 15;10(1):768. Epub 2019 Feb 15.

Department of Chemistry, The Hong Kong Branch of Chinese National Engineering Research Center for Tissue Restoration and Reconstruction, Institute of Molecular Functional Materials, Division of Life Science and State Key Laboratory of Molecular Neuroscience, The Hong Kong University of Science and Technology, Clear Water Bay, Kowloon, Hong Kong, 999077, China.

The exciting applications of molecular motion are still limited and are in urgent pursuit, although some fascinating concepts such as molecular motors and molecular machines have been proposed for years. Utilizing molecular motion in a nanoplatform for practical application has been scarcely explored due to some unconquered challenges such as how to achieve effective molecular motion in the aggregate state within nanoparticles. Here, we introduce a class of near infrared-absorbing organic molecules with intramolecular motion-induced photothermy inside nanoparticles, which enables most absorbed light energy to dissipate as heat. Read More

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http://www.nature.com/articles/s41467-019-08722-z
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http://dx.doi.org/10.1038/s41467-019-08722-zDOI Listing
February 2019
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Lack of androgen receptor SUMOylation results in male infertility due to epididymal dysfunction.

Nat Commun 2019 Feb 15;10(1):777. Epub 2019 Feb 15.

Institute of Biomedicine, University of Eastern Finland, FI-70211, Kuopio, Finland.

Androgen receptor (AR) is regulated by SUMOylation at its transactivation domain. In vitro, the SUMOylation is linked to transcriptional repression and/or target gene-selective regulation. Here, we generated a mouse model (ArKI) in which the conserved SUMO acceptor lysines of AR are permanently abolished (Ar). Read More

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http://dx.doi.org/10.1038/s41467-019-08730-zDOI Listing
February 2019

The Tec kinase ITK is essential for ILC2 survival and epithelial integrity in the intestine.

Nat Commun 2019 Feb 15;10(1):784. Epub 2019 Feb 15.

Department of Pathology, University of Massachusetts Medical School, Worcester, MA, 01605, USA.

Innate lymphoid cells (ILC) are lymphocytes that lack an antigen-specific receptor and are preferentially localized in non-lymphoid tissues, such as mucosal barriers. In these locations ILC respond to tissue perturbations by producing factors that promote tissue repair and improve barrier integrity. We show that mice lacking the Tec kinase ITK have impaired intestinal tissue integrity, and a reduced ability to restore homeostasis after tissue damage. Read More

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http://dx.doi.org/10.1038/s41467-019-08699-9DOI Listing
February 2019
10.742 Impact Factor

Tear resistance of soft collagenous tissues.

Nat Commun 2019 Feb 15;10(1):792. Epub 2019 Feb 15.

ETH Zurich, Institute for Mechanical Systems, 8092, Zurich, Switzerland.

Fracture toughness characterizes the ability of a material to maintain a certain level of strength despite the presence of a macroscopic crack. Understanding this tolerance for defects in soft collagenous tissues (SCT) has high relevance for assessing the risks of fracture after cutting, perforation or suturing. Here we investigate the peculiar toughening mechanisms of SCT through dedicated experiments and multi-scale simulations, showing that classical concepts of fracture mechanics are inadequate to quantify and explain the high defect tolerance of these materials. Read More

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http://dx.doi.org/10.1038/s41467-019-08723-yDOI Listing
February 2019

The rise and fall of cooperation through reputation and group polarization.

Nat Commun 2019 Feb 15;10(1):776. Epub 2019 Feb 15.

Department of Psychology, Leiden University, P.O. Box 9555, 2300 RB, Leiden, The Netherlands.

Humans exhibit a remarkable capacity for cooperation among genetically unrelated individuals. Yet, human cooperation is neither universal, nor stable. Instead, cooperation is often bounded to members of particular groups, and such groups endogenously form or break apart. Read More

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http://dx.doi.org/10.1038/s41467-019-08727-8DOI Listing
February 2019

Divalent EuRhSi as a reference for the Luttinger theorem and antiferromagnetism in trivalent heavy-fermion YbRhSi.

Nat Commun 2019 Feb 15;10(1):796. Epub 2019 Feb 15.

Donostia International Physics Center (DIPC), 20080, San Sebastian, Spain.

Application of the Luttinger theorem to the Kondo lattice YbRhSi suggests that its large 4f-derived Fermi surface (FS) in the paramagnetic (PM) regime should be similar in shape and volume to that of the divalent local-moment antiferromagnet (AFM) EuRhSi in its PM regime. Here we show by angle-resolved photoemission spectroscopy that paramagnetic EuRhSi has a large FS essentially similar to the one seen in YbRhSi down to 1 K. In EuRhSi the onset of AFM order below 24. Read More

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http://dx.doi.org/10.1038/s41467-019-08688-yDOI Listing
February 2019

Copy-choice recombination during mitochondrial L-strand synthesis causes DNA deletions.

Nat Commun 2019 Feb 15;10(1):759. Epub 2019 Feb 15.

Department of Medical Biochemistry and Cell Biology, University of Gothenburg, P.O. Box 440, Gothenburg, SE-405 30, Sweden.

Mitochondrial DNA (mtDNA) deletions are associated with mitochondrial disease, and also accumulate during normal human ageing. The mechanisms underlying mtDNA deletions remain unknown although several models have been proposed. Here we use deep sequencing to characterize abundant mtDNA deletions in patients with mutations in mitochondrial DNA replication factors, and show that these have distinct directionality and repeat characteristics. Read More

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http://dx.doi.org/10.1038/s41467-019-08673-5DOI Listing
February 2019

Mutation of a single residue promotes gating of vertebrate and invertebrate two-pore domain potassium channels.

Nat Commun 2019 Feb 15;10(1):787. Epub 2019 Feb 15.

Institut NeuroMyoGène, Univ Lyon, Université Claude Bernard Lyon 1, CNRS UMR 5310, INSERM U1217, Lyon, 69008, France.

Mutations that modulate the activity of ion channels are essential tools to understand the biophysical determinants that control their gating. Here, we reveal the conserved role played by a single amino acid position (TM2.6) located in the second transmembrane domain of two-pore domain potassium (K2P) channels. Read More

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http://dx.doi.org/10.1038/s41467-019-08710-3DOI Listing
February 2019

Recessive mutations in muscle-specific isoforms of FXR1 cause congenital multi-minicore myopathy.

Nat Commun 2019 Feb 15;10(1):797. Epub 2019 Feb 15.

Instituto de Investigaciones Biomédicas "Alberto Sols", CSIC-UAM, 28029, Madrid, Spain.

FXR1 is an alternatively spliced gene that encodes RNA binding proteins (FXR1P) involved in muscle development. In contrast to other tissues, cardiac and skeletal muscle express two FXR1P isoforms that incorporate an additional exon-15. We report that recessive mutations in this particular exon of FXR1 cause congenital multi-minicore myopathy in humans and mice. Read More

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http://dx.doi.org/10.1038/s41467-019-08548-9DOI Listing
February 2019

Non-lytic clearance of influenza B virus from infected cells preserves epithelial barrier function.

Nat Commun 2019 Feb 15;10(1):779. Epub 2019 Feb 15.

Department of Molecular Genetics and Microbiology, Duke University School of Medicine, Durham, NC, 27710, USA.

Influenza B virus (IBV) is an acute, respiratory RNA virus that has been assumed to induce the eventual death of all infected cells. We and others have shown however, that infection with apparently cytopathic viruses does not necessarily lead to cell death; some cells can intrinsically clear the virus and persist in the host long-term. To determine if any cells can survive direct IBV infection, we here generate a recombinant IBV capable of activating a host-cell reporter to permanently label all infected cells. Read More

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http://dx.doi.org/10.1038/s41467-019-08617-zDOI Listing
February 2019

ASPP proteins discriminate between PP1 catalytic subunits through their SH3 domain and the PP1 C-tail.

Nat Commun 2019 Feb 15;10(1):771. Epub 2019 Feb 15.

Apoptosis and Proliferation Control Laboratory, The Francis Crick Institute, 1 Midland Road, London, NW1 1AT, UK.

Serine/threonine phosphatases such as PP1 lack substrate specificity and associate with a large array of targeting subunits to achieve the requisite selectivity. The tumour suppressor ASPP (apoptosis-stimulating protein of p53) proteins associate with PP1 catalytic subunits and are implicated in multiple functions from transcriptional regulation to cell junction remodelling. Here we show that Drosophila ASPP is part of a multiprotein PP1 complex and that PP1 association is necessary for several in vivo functions of Drosophila ASPP. Read More

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http://dx.doi.org/10.1038/s41467-019-08686-0DOI Listing
February 2019

Evidence of cooperative effect on the enhanced superconducting transition temperature at the FeSe/SrTiO interface.

Nat Commun 2019 Feb 15;10(1):758. Epub 2019 Feb 15.

State Key Laboratory of Surface Physics and Department of Physics, Fudan University, 200433, Shanghai, China.

At the interface between monolayer FeSe films and SrTiO substrates the superconducting transition temperature (T) is unexpectedly high, triggering a surge of excitement. The mechanism for the T enhancement has been the central question, as it may present a new strategy for seeking out higher T materials. To reveal this enigmatic mechanism, by combining advances in high quality interface growth, O [Formula: see text] O isotope substitution, and extensive data from angle resolved photoemission spectroscopy, we provide striking evidence that the high T in FeSe/SrTiO is the cooperative effect of the intrinsic pairing mechanism in the FeSe and interactions between the FeSe electrons and SrTiO phonons. Read More

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http://dx.doi.org/10.1038/s41467-019-08560-zDOI Listing
February 2019

A multi-substrate screening approach for the identification of a broadly applicable Diels-Alder catalyst.

Nat Commun 2019 Feb 15;10(1):770. Epub 2019 Feb 15.

Max-Planck-Institut für Kohlenforschung, Kaiser-Wilhelm-Platz 1, D-45470, Mülheim an der Ruhr, Germany.

When developing a synthetic methodology, chemists generally optimize a single substrate and then explore the substrate scope of their method. This approach has led to innumerable and widely-used chemical reactions. However, it frequently provides methods that only work on model substrate-like compounds. Read More

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http://dx.doi.org/10.1038/s41467-019-08374-zDOI Listing
February 2019

Gigaxonin E3 ligase governs ATG16L1 turnover to control autophagosome production.

Nat Commun 2019 Feb 15;10(1):780. Epub 2019 Feb 15.

Avenir-Atip team, INM, INSERM, Université Montpellier, 34091, Montpellier, France.

Autophagy is an essential self-digestion machinery for cell survival and homoeostasis. Membrane elongation is fundamental, as it drives the formation of the double-membrane vesicles that engulf cytosolic material. LC3-lipidation, the signature of autophagosome formation, results from a complex ubiquitin-conjugating cascade orchestrated by the ATG16L1 protein, whose regulation is unknown. Read More

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http://dx.doi.org/10.1038/s41467-019-08331-wDOI Listing
February 2019

Multimaterial actinic spatial control 3D and 4D printing.

Nat Commun 2019 Feb 15;10(1):791. Epub 2019 Feb 15.

Department of Chemistry, University of Washington, Seattle, WA, 98195, USA.

Production of objects with varied mechanical properties is challenging for current manufacturing methods. Additive manufacturing could make these multimaterial objects possible, but methods able to achieve multimaterial control along all three axes of printing are limited. Here we report a multi-wavelength method of vat photopolymerization that provides chemoselective wavelength-control over material composition utilizing multimaterial actinic spatial control (MASC) during additive manufacturing. Read More

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http://dx.doi.org/10.1038/s41467-019-08639-7DOI Listing
February 2019

Ripplocations provide a new mechanism for the deformation of phyllosilicates in the lithosphere.

Nat Commun 2019 Feb 15;10(1):686. Epub 2019 Feb 15.

Drexel University, Philadelphia, PA, 19104, USA.

Deformation in Earth's lithosphere is localised in narrow, high-strain zones. Phyllosilicates, strongly anisotropic layered minerals, are abundant in these rocks, where they accommodate much of the strain and play a significant role in inhibiting or triggering earthquakes. Until now it was understood that phyllosilicates could deform only by dislocation glide along layers and could not accommodate large strains without cracking and dilation. Read More

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http://dx.doi.org/10.1038/s41467-019-08587-2DOI Listing
February 2019

Evidence for electron Landau damping in space plasma turbulence.

Nat Commun 2019 Feb 14;10(1):740. Epub 2019 Feb 14.

Department of Physics and Astronomy, University of Iowa, Iowa City, IA, 52242, USA.

How turbulent energy is dissipated in weakly collisional space and astrophysical plasmas is a major open question. Here, we present the application of a field-particle correlation technique to directly measure the transfer of energy between the turbulent electromagnetic field and electrons in the Earth's magnetosheath, the region of solar wind downstream of the Earth's bow shock. The measurement of the secular energy transfer from the parallel electric field as a function of electron velocity shows a signature consistent with Landau damping. Read More

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http://dx.doi.org/10.1038/s41467-019-08435-3DOI Listing
February 2019

Retrospective model-based inference guides model-free credit assignment.

Nat Commun 2019 Feb 14;10(1):750. Epub 2019 Feb 14.

Max Planck UCL Centre for Computational Psychiatry and Ageing Research, University College London, 10-12 Russell Square, London, WC1B 5EH, UK.

An extensive reinforcement learning literature shows that organisms assign credit efficiently, even under conditions of state uncertainty. However, little is known about credit-assignment when state uncertainty is subsequently resolved. Here, we address this problem within the framework of an interaction between model-free (MF) and model-based (MB) control systems. Read More

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http://dx.doi.org/10.1038/s41467-019-08662-8DOI Listing
February 2019

Numerous cultivated and uncultivated viruses encode ribosomal proteins.

Nat Commun 2019 Feb 14;10(1):752. Epub 2019 Feb 14.

Unité de Biologie Moléculaire du Gène chez les Extrêmophiles, Département de Microbiologie, Institut Pasteur, Paris, 75015, France.

Viruses modulate ecosystems by directly altering host metabolisms through auxiliary metabolic genes. However, viral genomes are not known to encode the core components of translation machinery, such as ribosomal proteins (RPs). Here, using reference genomes and global-scale viral metagenomic datasets, we identify 14 different RPs across viral genomes arising from cultivated viral isolates and metagenome-assembled viruses. Read More

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http://dx.doi.org/10.1038/s41467-019-08672-6DOI Listing
February 2019

Perceptions of bioenergy with carbon capture and storage in different policy scenarios.

Nat Commun 2019 Feb 14;10(1):743. Epub 2019 Feb 14.

School of Geographical Sciences, University of Bristol, University Road, Bristol, BS8 1SS, UK.

There is growing interest in bioenergy with carbon capture and storage (BECCS) as a possible technology for removing CO from the atmosphere. In the first study of its kind, we investigate whether and how different forms of incentivisation impact on public perceptions of this technology. We develop a new experimental method to triangulate perceptions of BECCS in different policy scenarios through quantitative measurement and qualitative elicitation. Read More

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http://dx.doi.org/10.1038/s41467-019-08592-5DOI Listing
February 2019

Subcortical electrophysiological activity is detectable with high-density EEG source imaging.

Nat Commun 2019 Feb 14;10(1):753. Epub 2019 Feb 14.

Functional Brain Mapping Laboratory, Department of Fundamental Neurosciences, Campus Biotech, University of Geneva, 1201, Geneva, Switzerland.

Subcortical neuronal activity is highly relevant for mediating communication in large-scale brain networks. While electroencephalographic (EEG) recordings provide appropriate temporal resolution and coverage to study whole brain dynamics, the feasibility to detect subcortical signals is a matter of debate. Here, we investigate if scalp EEG can detect and correctly localize signals recorded with intracranial electrodes placed in the centromedial thalamus, and in the nucleus accumbens. Read More

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http://dx.doi.org/10.1038/s41467-019-08725-wDOI Listing
February 2019

A Pólya urn approach to information filtering in complex networks.

Nat Commun 2019 Feb 14;10(1):745. Epub 2019 Feb 14.

Department of Computer Science, University College London, 66-72 Gower Street, London, WC1E 6EA, UK.

The increasing availability of data demands for techniques to filter information in large complex networks of interactions. A number of approaches have been proposed to extract network backbones by assessing the statistical significance of links against null hypotheses of random interaction. Yet, it is well known that the growth of most real-world networks is non-random, as past interactions between nodes typically increase the likelihood of further interaction. Read More

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http://dx.doi.org/10.1038/s41467-019-08667-3DOI Listing
February 2019

Diversity within the adenovirus fiber knob hypervariable loops influences primary receptor interactions.

Nat Commun 2019 Feb 14;10(1):741. Epub 2019 Feb 14.

Division of Cancer and Genetics, School of Medicine, Cardiff University, Cardiff, CF14 4XN, UK.

Adenovirus based vectors are of increasing importance for wide ranging therapeutic applications. As vaccines, vectors derived from human adenovirus species D serotypes 26 and 48 (HAdV-D26/48) are demonstrating promising efficacy as protective platforms against infectious diseases. Significant clinical progress has been made, yet definitive studies underpinning mechanisms of entry, infection, and receptor usage are currently lacking. Read More

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http://dx.doi.org/10.1038/s41467-019-08599-yDOI Listing
February 2019

Macrophage achieves self-protection against oxidative stress-induced ageing through the Mst-Nrf2 axis.

Nat Commun 2019 Feb 14;10(1):755. Epub 2019 Feb 14.

State Key Laboratory of Cellular Stress Biology, Innovation Center for Cell Signaling Network, School of Life Sciences, Xiamen University, Xiamen, Fujian, 361102, China.

Reactive oxygen species (ROS) production in phagocytes is a major defense mechanism against pathogens. However, the cellular self-protective mechanism against such potential damage from oxidative stress remains unclear. Here we show that the kinases Mst1 and Mst2 (Mst1/2) sense ROS and maintain cellular redox balance by modulating the stability of antioxidant transcription factor Nrf2. Read More

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http://dx.doi.org/10.1038/s41467-019-08680-6DOI Listing
February 2019

Decadal biomass increment in early secondary succession woody ecosystems is increased by CO enrichment.

Nat Commun 2019 Feb 14;10(1):454. Epub 2019 Feb 14.

Environmental Sciences Division and Climate Change Science Institute, Oak Ridge National Laboratory, Oak Ridge, 37831-6301, TN, USA.

Increasing atmospheric CO stimulates photosynthesis which can increase net primary production (NPP), but at longer timescales may not necessarily increase plant biomass. Here we analyse the four decade-long CO-enrichment experiments in woody ecosystems that measured total NPP and biomass. CO enrichment increased biomass increment by 1. Read More

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http://dx.doi.org/10.1038/s41467-019-08348-1DOI Listing
February 2019

Bose-Einstein condensation of photons in an erbium-ytterbium co-doped fiber cavity.

Nat Commun 2019 Feb 14;10(1):747. Epub 2019 Feb 14.

The Andrew & Erna Viterbi Faculty of Electrical Engineering, Technion, 32000, Haifa, Israel.

Bose-Einstein condensation (BEC) is a special many-boson phenomenon that was observed in atomic particles at ultra-low temperatures. Later, BEC was also shown for non-atomic bosons, such as photons. Those experiments were usually done in micron-size cavities, where the power (particle number) was varied, and not the temperature, until condensation was reached. Read More

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http://dx.doi.org/10.1038/s41467-019-08527-0DOI Listing
February 2019