24,567 results match your criteria Nature Communications [Journal]


Publisher Correction: Nitric oxide-dependent anaerobic ammonium oxidation.

Nat Commun 2019 Apr 18;10(1):1910. Epub 2019 Apr 18.

Department of Microbiology, IWWR, Radboud University Nijmegen, Heyendaalseweg 135, 6525AJ, Nijmegen, The Netherlands.

The original HTML version of this Article had an incorrect Published online date of 20 March 2019; it should have been 18 March 2019. This has been corrected in the HTML version of the Article. The PDF version was correct from the time of publication. Read More

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http://www.nature.com/articles/s41467-019-09797-4
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http://dx.doi.org/10.1038/s41467-019-09797-4DOI Listing
April 2019
1 Read

High entropy alloys as a bold step forward in alloy development.

Authors:
D B Miracle

Nat Commun 2019 Apr 18;10(1):1805. Epub 2019 Apr 18.

Air Force Research Laboratory, Materials and Manufacturing Directorate, Wright-Patterson AFB, OH, 45433, USA.

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http://dx.doi.org/10.1038/s41467-019-09700-1DOI Listing

New estimates of flood exposure in developing countries using high-resolution population data.

Nat Commun 2019 Apr 18;10(1):1814. Epub 2019 Apr 18.

Fathom, The Engine Shed, Station Approach, Bristol, BS1 6QH, UK.

Current estimates of global flood exposure are made using datasets that distribute population counts homogenously across large lowland floodplain areas. When intersected with simulated water depths, this results in a significant mis-estimation. Here, we use new highly resolved population information to show that, in reality, humans make more rational decisions about flood risk than current demographic data suggest. Read More

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http://dx.doi.org/10.1038/s41467-019-09282-yDOI Listing
April 2019
1 Read

Felodipine induces autophagy in mouse brains with pharmacokinetics amenable to repurposing.

Nat Commun 2019 Apr 18;10(1):1817. Epub 2019 Apr 18.

Department of Medical Genetics, Cambridge Institute for Medical Research, University of Cambridge, The Keith Peters Building, Cambridge Biomedical Campus, Hills Road, Cambridge, CB2 0XY, UK.

Neurodegenerative diseases like Alzheimer's disease, Parkinson's disease and Huntington's disease manifest with the neuronal accumulation of toxic proteins. Since autophagy upregulation enhances the clearance of such proteins and ameliorates their toxicities in animal models, we and others have sought to re-position/re-profile existing compounds used in humans to identify those that may induce autophagy in the brain. A key challenge with this approach is to assess if any hits identified can induce neuronal autophagy at concentrations that would be seen in humans taking the drug for its conventional indication. Read More

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http://www.nature.com/articles/s41467-019-09494-2
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http://dx.doi.org/10.1038/s41467-019-09494-2DOI Listing
April 2019
1 Read

L amino acid transporter structure and molecular bases for the asymmetry of substrate interaction.

Nat Commun 2019 Apr 18;10(1):1807. Epub 2019 Apr 18.

Institute for Research in Biomedicine (IRB Barcelona), Barcelona Institute of Science and Technology, 08028, Barcelona, Spain.

L-amino acid transporters (LATs) play key roles in human physiology and are implicated in several human pathologies. LATs are asymmetric amino acid exchangers where the low apparent affinity cytoplasmic side controls the exchange of substrates with high apparent affinity on the extracellular side. Here, we report the crystal structures of an LAT, the bacterial alanine-serine-cysteine exchanger (BasC), in a non-occluded inward-facing conformation in both apo and substrate-bound states. Read More

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http://dx.doi.org/10.1038/s41467-019-09837-zDOI Listing

Reconstitution of the lipid-linked oligosaccharide pathway for assembly of high-mannose N-glycans.

Nat Commun 2019 Apr 18;10(1):1813. Epub 2019 Apr 18.

Key Laboratory of Carbohydrate Chemistry and Biotechnology, Ministry of Education, School of Biotechnology, Jiangnan University, 214122, Wuxi, China.

The asparagine (N)-linked Man9GlcNAc2 is required for glycoprotein folding and secretion. Understanding how its structure contributes to these functions has been stymied by our inability to produce this glycan as a homogenous structure of sufficient quantities for study. Here, we report the high yield chemoenzymatic synthesis of Man9GlcNAc2 and its biosynthetic intermediates by reconstituting the eukaryotic lipid-linked oligosaccharide (LLO) pathway. Read More

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http://dx.doi.org/10.1038/s41467-019-09752-3DOI Listing

Hierarchical self-assembly of 3D lattices from polydisperse anisometric colloids.

Nat Commun 2019 Apr 18;10(1):1815. Epub 2019 Apr 18.

Department of Materials Science and Engineering, University of Illinois, Urbana, IL, 61801, USA.

Colloids are mainly divided into two types defined by size. Micron-scale colloids are widely used as model systems to study phase transitions, while nanoparticles have physicochemical properties unique to their size. Here we study a promising yet underexplored third type: anisometric colloids, which integrate micrometer and nanometer dimensions into the same particle. Read More

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http://dx.doi.org/10.1038/s41467-019-09787-6DOI Listing

Author Correction: Solution-processed hybrid perovskite photodetectors with high detectivity.

Nat Commun 2019 Apr 18;10(1):1866. Epub 2019 Apr 18.

Department of Materials Science and Engineering, University of California,, Los Angeles, California, 90095, USA.

This Article contains an error in Equation 2 in that the denominator is inverted. This has not been fixed in the PDF or HTML versions of the Article but can be seen in the associated Correction. Read More

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http://www.nature.com/articles/s41467-019-09822-6
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April 2019
1 Read

Colossal barocaloric effects near room temperature in plastic crystals of neopentylglycol.

Nat Commun 2019 Apr 18;10(1):1803. Epub 2019 Apr 18.

Grup de Caracterizació de Materials, Departament de Física, EEBE and Barcelona Research Center in Multiscale Science and Engineering, Universitat Politècnica de Catalunya, Eduard Maristany, 10-14, 08019, Barcelona, Catalonia, Spain.

There is currently great interest in replacing the harmful volatile hydrofluorocarbon fluids used in refrigeration and air-conditioning with solid materials that display magnetocaloric, electrocaloric or mechanocaloric effects. However, the field-driven thermal changes in all of these caloric materials fall short with respect to their fluid counterparts. Here we show that plastic crystals of neopentylglycol (CH)C(CHOH) display extremely large pressure-driven thermal changes near room temperature due to molecular reconfiguration, that these changes outperform those observed in any type of caloric material, and that these changes are comparable with those exploited commercially in hydrofluorocarbons. Read More

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http://dx.doi.org/10.1038/s41467-019-09730-9DOI Listing

Publisher Correction: A network of chaperones prevents and detects failures in membrane protein lipid bilayer integration.

Nat Commun 2019 Apr 18;10(1):1908. Epub 2019 Apr 18.

Center for Integrated Protein Science at the Department of Chemistry, Technical University of Munich, Lichtenbergstr. 4, 85748, Garching, Germany.

The original version of this Article contained errors in Fig. 1 and Supplementary Fig. 3. Read More

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http://dx.doi.org/10.1038/s41467-019-09912-5DOI Listing

ZFP30 promotes adipogenesis through the KAP1-mediated activation of a retrotransposon-derived Pparg2 enhancer.

Nat Commun 2019 Apr 18;10(1):1809. Epub 2019 Apr 18.

Laboratory of Systems Biology and Genetics, Institute of Bioengineering, School of Life Sciences, Ecole Polytechnique Fédérale de Lausanne (EPFL), CH-1015, Lausanne, Switzerland.

Krüppel-associated box zinc finger proteins (KZFPs) constitute the largest family of mammalian transcription factors, but most remain completely uncharacterized. While initially proposed to primarily repress transposable elements, recent reports have revealed that KFZPs contribute to a wide variety of other biological processes. Using murine and human in vitro and in vivo models, we demonstrate here that one poorly studied KZFP, ZFP30, promotes adipogenesis by directly targeting and activating a retrotransposon-derived Pparg2 enhancer. Read More

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http://www.nature.com/articles/s41467-019-09803-9
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April 2019
2 Reads

Bayesian nonparametric models characterize instantaneous strategies in a competitive dynamic game.

Nat Commun 2019 Apr 18;10(1):1808. Epub 2019 Apr 18.

Duke Institute for Brain Sciences, Duke University, Durham, 27710, NC, USA.

Previous studies of strategic social interaction in game theory have predominantly used games with clearly-defined turns and limited choices. Yet, most real-world social behaviors involve dynamic, coevolving decisions by interacting agents, which poses challenges for creating tractable models of behavior. Here, using a game in which humans competed against both real and artificial opponents, we show that it is possible to quantify the instantaneous dynamic coupling between agents. Read More

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http://dx.doi.org/10.1038/s41467-019-09789-4DOI Listing

Integrating temporal and spatial control of electronic transitions for bright multiphoton upconversion.

Nat Commun 2019 Apr 18;10(1):1811. Epub 2019 Apr 18.

Department of Materials Science and Engineering, City University of Hong Kong, 83 Tat Chee Avenue, Hong Kong, SAR, China.

The applications of lanthanide-doped upconversion nanomaterials are limited by unsatisfactory brightness currently. Herein, a general strategy is proposed for boosting the upconversion efficiency in Er ions, based on combined use of a core-shell nanostructured host and an integrated optical waveguide circuit excitation platform. A NaErF@NaYF core-shell nanoparticle is constructed to host the upconversion process for minimizing non-radiative dissipation of excitation energy by surface quenchers. Read More

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http://dx.doi.org/10.1038/s41467-019-09850-2DOI Listing

Self-organization of Plk4 regulates symmetry breaking in centriole duplication.

Nat Commun 2019 Apr 18;10(1):1810. Epub 2019 Apr 18.

Graduate School of Pharmaceutical Sciences, The University of Tokyo, Hongo, Tokyo, 113-0033, Japan.

During centriole duplication, a single daughter centriole is formed next to the mother centriole. The molecular mechanism that determines a single duplication site remains a long-standing question. Here, we show that intrinsic self-organization of Plk4 is implicated in symmetry breaking in the process of centriole duplication. Read More

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http://www.nature.com/articles/s41467-019-09847-x
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April 2019
1 Read

AURKB as a target in non-small cell lung cancer with acquired resistance to anti-EGFR therapy.

Nat Commun 2019 Apr 18;10(1):1812. Epub 2019 Apr 18.

Laboratory of Oncology, Pangaea Oncology, Quiron Dexeus University Hospital, 08028, Barcelona, Spain.

Non-small cell lung cancer (NSCLC) tumors harboring mutations in EGFR ultimately relapse to therapy with EGFR tyrosine kinase inhibitors (EGFR TKIs). Here, we show that resistant cells without the p.T790M or other acquired mutations are sensitive to the Aurora B (AURKB) inhibitors barasertib and S49076. Read More

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http://dx.doi.org/10.1038/s41467-019-09734-5DOI Listing

Author Correction: Environment-responsive nanophores for therapy and treatment monitoring via molecular MRI quenching.

Nat Commun 2019 Apr 18;10(1):1867. Epub 2019 Apr 18.

Molecular Pharmacology and Chemistry Program, Memorial Sloan Kettering Cancer Center, 1275 York Avenue, New York, New York, 10065, USA.

This Article contains an error in Figure 6. In panel b, the left-hand image is mistakenly described as showing fluorescence before treatment, while it in fact shows the same white light image as the right-hand panel without fluorescent overlay to better visualize the tumour location. A correct version of Figure 6b is presented in the accompanying Author Correction. Read More

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http://dx.doi.org/10.1038/s41467-019-09887-3DOI Listing

Dishevelled-3 conformation dynamics analyzed by FRET-based biosensors reveals a key role of casein kinase 1.

Nat Commun 2019 Apr 18;10(1):1804. Epub 2019 Apr 18.

Department of Experimental Biology, Faculty of Science, Masaryk University, Brno, 62500, Czech Republic.

Dishevelled (DVL) is the key component of the Wnt signaling pathway. Currently, DVL conformational dynamics under native conditions is unknown. To overcome this limitation, we develop the Fluorescein Arsenical Hairpin Binder- (FlAsH-) based FRET in vivo approach to study DVL conformation in living cells. Read More

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http://dx.doi.org/10.1038/s41467-019-09651-7DOI Listing

Femtosecond time synchronization of optical clocks off of a flying quadcopter.

Nat Commun 2019 Apr 18;10(1):1819. Epub 2019 Apr 18.

National Institute of Standards and Technology, 325 Broadway, Boulder, CO, 80305, USA.

Future optical clock networks will require free-space optical time-frequency transfer between flying clocks. However, simple one-way or standard two-way time transfer between flying clocks will completely break down because of the time-of-flight variations and Doppler shifts associated with the strongly time-varying link distances. Here, we demonstrate an advanced, frequency comb-based optical two-way time-frequency transfer (O-TWTFT) that can successfully synchronize the optical timescales at two sites connected via a time-varying turbulent air path. Read More

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http://www.nature.com/articles/s41467-019-09768-9
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http://dx.doi.org/10.1038/s41467-019-09768-9DOI Listing
April 2019
1 Read

Metabolic potential of uncultured bacteria and archaea associated with petroleum seepage in deep-sea sediments.

Nat Commun 2019 Apr 18;10(1):1816. Epub 2019 Apr 18.

Department of Biological Sciences, University of Calgary, Calgary, AB, T2N 1N4, Canada.

The lack of microbial genomes and isolates from the deep seabed means that very little is known about the ecology of this vast habitat. Here, we investigate energy and carbon acquisition strategies of microbial communities from three deep seabed petroleum seeps (3 km water depth) in the Eastern Gulf of Mexico. Shotgun metagenomic analysis reveals that each sediment harbors diverse communities of chemoheterotrophs and chemolithotrophs. Read More

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http://www.nature.com/articles/s41467-019-09747-0
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http://dx.doi.org/10.1038/s41467-019-09747-0DOI Listing
April 2019
1 Read

Spatiotemporal control of coacervate formation within liposomes.

Nat Commun 2019 Apr 17;10(1):1800. Epub 2019 Apr 17.

Department of Bionanoscience, Kavli Institute of Nanoscience Delft, Delft University of Technology, Van der Maasweg 9, 2629 HZ, Delft, The Netherlands.

Liquid-liquid phase separation (LLPS), especially coacervation, plays a crucial role in cell biology, as it forms numerous membraneless organelles in cells. Coacervates play an indispensable role in regulating intracellular biochemistry, and their dysfunction is associated with several diseases. Understanding of the LLPS dynamics would greatly benefit from controlled in vitro assays that mimic cells. Read More

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http://www.nature.com/articles/s41467-019-09855-x
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http://dx.doi.org/10.1038/s41467-019-09855-xDOI Listing
April 2019
1 Read

Bacterial glycosyltransferase-mediated cell-surface chemoenzymatic glycan modification.

Nat Commun 2019 Apr 17;10(1):1799. Epub 2019 Apr 17.

Department of Molecular Medicine, The Scripps Research Institute, La Jolla, CA, 92037, USA.

Chemoenzymatic modification of cell-surface glycan structures has emerged as a complementary approach to metabolic oligosaccharide engineering. Here, we identify Pasteurella multocida α2-3-sialyltransferase M144D mutant, Photobacterium damsela α2-6-sialyltransferase, and Helicobacter mustelae α1-2-fucosyltransferase, as efficient tools for live-cell glycan modification. Combining these enzymes with Helicobacter pylori α1-3-fucosyltransferase, we develop a host-cell-based assay to probe glycan-mediated influenza A virus (IAV) infection including wild-type and mutant strains of H1N1 and H3N2 subtypes. Read More

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http://www.nature.com/articles/s41467-019-09608-w
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April 2019
1 Read
10.742 Impact Factor

Cross-reactive neutralizing human survivor monoclonal antibody BDBV223 targets the ebolavirus stalk.

Nat Commun 2019 Apr 17;10(1):1788. Epub 2019 Apr 17.

Department of Immunology and Microbiology, The Scripps Research Institute, La Jolla, CA, 92037, USA.

Three Ebolavirus genus viruses cause lethal disease and lack targeted therapeutics: Ebola virus, Sudan virus and Bundibugyo virus. Monoclonal antibody (mAb) cocktails against the surface glycoprotein (GP) present a potential therapeutic strategy. Here we report two crystal structures of the antibody BDBV223, alone and complexed with its GP2 stalk epitope, an interesting site for therapeutic/vaccine design due to its high sequence conservation among ebolaviruses. Read More

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http://www.nature.com/articles/s41467-019-09732-7
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http://dx.doi.org/10.1038/s41467-019-09732-7DOI Listing
April 2019
1 Read

Hydrophobic carbon dots with blue dispersed emission and red aggregation-induced emission.

Nat Commun 2019 Apr 17;10(1):1789. Epub 2019 Apr 17.

Guangdong Provincial Engineering Technology Research Center for Optical Agriculture, College of Materials and Energy, South China Agricultural University, 510642, Guangzhou, China.

Carbon dots (CDs) have been studied for years as one of the most promising fluorescent nanomaterials. However, CDs with red or solid-state fluorescence are rarely reported. Herein, through a one-pot solvothermal treatment, hydrophobic CDs (H-CDs) with blue dispersed emission and red aggregation-induced emission are obtained. Read More

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http://www.nature.com/articles/s41467-019-09830-6
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April 2019
1 Read

Self-organization of swimmers drives long-range fluid transport in bacterial colonies.

Nat Commun 2019 Apr 17;10(1):1792. Epub 2019 Apr 17.

Department of Physics and Shenzhen Research Institute, The Chinese University of Hong Kong, Shatin, New Territories, Hong Kong, People's Republic of China.

Motile subpopulations in microbial communities are believed to be important for dispersal, quest for food, and material transport. Here, we show that motile cells in sessile colonies of peritrichously flagellated bacteria can self-organize into two adjacent, centimeter-scale motile rings surrounding the entire colony. The motile rings arise from spontaneous segregation of a homogeneous swimmer suspension that mimics a phase separation; the process is mediated by intercellular interactions and shear-induced depletion. Read More

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http://www.nature.com/articles/s41467-019-09818-2
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April 2019
1 Read

An additive Gaussian process regression model for interpretable non-parametric analysis of longitudinal data.

Nat Commun 2019 Apr 17;10(1):1798. Epub 2019 Apr 17.

Department of Computer Science, Aalto University School of Science, FI-00076, Aalto, Finland.

Biomedical research typically involves longitudinal study designs where samples from individuals are measured repeatedly over time and the goal is to identify risk factors (covariates) that are associated with an outcome value. General linear mixed effect models are the standard workhorse for statistical analysis of longitudinal data. However, analysis of longitudinal data can be complicated for reasons such as difficulties in modelling correlated outcome values, functional (time-varying) covariates, nonlinear and non-stationary effects, and model inference. Read More

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http://www.nature.com/articles/s41467-019-09785-8
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April 2019
1 Read

The Stat3-Fam3a axis promotes muscle stem cell myogenic lineage progression by inducing mitochondrial respiration.

Nat Commun 2019 Apr 17;10(1):1796. Epub 2019 Apr 17.

Development, Aging and Regeneration Program, Sanford Burnham Prebys Medical Discovery Institute, 10901N Torrey Pines Road, La Jolla, CA, 92037, USA.

Metabolic reprogramming is an active regulator of stem cell fate choices, and successful stem cell differentiation in different compartments requires the induction of oxidative phosphorylation. However, the mechanisms that promote mitochondrial respiration during stem cell differentiation are poorly understood. Here we demonstrate that Stat3 promotes muscle stem cell myogenic lineage progression by stimulating mitochondrial respiration in mice. Read More

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http://dx.doi.org/10.1038/s41467-019-09746-1DOI Listing

Author Correction: Clear and transparent nanocrystals for infrared-responsive carrier transfer.

Nat Commun 2019 Apr 17;10(1):1879. Epub 2019 Apr 17.

Institute for Chemical Research, Kyoto University, Gokasho, Uji, Kyoto, 611-0011, Japan.

The original version of this Article omitted the fourth author Taizo Yoshinaga, who is from the 'Graduate School of Pure and Applied Sciences, University of Tsukuba, 1-1-1 Tennodai, Tsukuba, Japan'. Consequently, the third sentence of the Author Contributions, 'M.S. Read More

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http://www.nature.com/articles/s41467-019-09888-2
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April 2019
1 Read

Author Correction: Crizotinib-induced immunogenic cell death in non-small cell lung cancer.

Nat Commun 2019 Apr 17;10(1):1883. Epub 2019 Apr 17.

Cell Biology and Metabolomics Platforms, Gustave Roussy Cancer Campus, Villejuif, 94805, France.

The original version of this Article contained an error in the spelling of the author Lin Xia, which was incorrectly given as Xia Lin. This has now been corrected in both the PDF and HTML versions of the Article. Read More

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http://www.nature.com/articles/s41467-019-09838-y
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April 2019
3 Reads

Laser restructuring and photoluminescence of glass-clad GaSb/Si-core optical fibres.

Nat Commun 2019 Apr 17;10(1):1790. Epub 2019 Apr 17.

Department of Physics; PoreLab, Norwegian University of Science and Technology, N-7491, Trondheim, Norway.

Semiconductor-core optical fibres have potential applications in photonics and optoelectronics due to large nonlinear optical coefficients and an extended transparency window. Laser processing can impose large temperature gradients, an ability that has been used to improve the uniformity of unary fibre cores, and to inscribe compositional variations in alloy systems. Interest in an integrated light-emitting element suggests a move from Group IV to III-V materials, or a core that contains both. Read More

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http://www.nature.com/articles/s41467-019-09835-1
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April 2019
1 Read

Therapeutic role of miR-19a/19b in cardiac regeneration and protection from myocardial infarction.

Nat Commun 2019 Apr 17;10(1):1802. Epub 2019 Apr 17.

Department of Cardiology, Boston Children's Hospital, Harvard Medical School, 300 Longwood Avenue, Boston, MA, 02115, USA.

The primary cause of heart failure is the loss of cardiomyocytes in the diseased adult heart. Previously, we reported that the miR-17-92 cluster plays a key role in cardiomyocyte proliferation. Here, we report that expression of miR-19a/19b, members of the miR-17-92 cluster, is induced in heart failure patients. Read More

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http://www.nature.com/articles/s41467-019-09530-1
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April 2019
1 Read

A conserved CCM complex promotes apoptosis non-autonomously by regulating zinc homeostasis.

Nat Commun 2019 Apr 17;10(1):1791. Epub 2019 Apr 17.

Department of Molecular Genetics, University of Toronto, Toronto, M5S 1A8, ON, Canada.

Apoptotic death of cells damaged by genotoxic stress requires regulatory input from surrounding tissues. The C. elegans scaffold protein KRI-1, ortholog of mammalian KRIT1/CCM1, permits DNA damage-induced apoptosis of cells in the germline by an unknown cell non-autonomous mechanism. Read More

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http://www.nature.com/articles/s41467-019-09829-z
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April 2019
1 Read

Major vault protein suppresses obesity and atherosclerosis through inhibiting IKK-NF-κB signaling mediated inflammation.

Nat Commun 2019 Apr 17;10(1):1801. Epub 2019 Apr 17.

Department of Pathophysiology, Key Laboratory of Cardiovascular Disease and Molecular Intervention, Nanjing Medical University, Nanjing 211166, China.

Macrophage-orchestrated, low-grade chronic inflammation plays a pivotal role in obesity and atherogenesis. However, the underlying regulatory mechanisms remain incompletely understood. Here, we identify major vault protein (MVP), the main component of unique cellular ribonucleoprotein particles, as a suppressor for NF-κB signaling in macrophages. Read More

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http://dx.doi.org/10.1038/s41467-019-09588-xDOI Listing

Additive-free MXene inks and direct printing of micro-supercapacitors.

Nat Commun 2019 Apr 17;10(1):1795. Epub 2019 Apr 17.

CRANN and AMBER Research Centers, Trinity College Dublin, Dublin 2, Ireland.

Direct printing of functional inks is critical for applications in diverse areas including electrochemical energy storage, smart electronics and healthcare. However, the available printable ink formulations are far from ideal. Either surfactants/additives are typically involved or the ink concentration is low, which add complexity to the manufacturing and compromises the printing resolution. Read More

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http://www.nature.com/articles/s41467-019-09398-1
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http://dx.doi.org/10.1038/s41467-019-09398-1DOI Listing
April 2019
1 Read

Small molecule electro-optical binding assay using nanopores.

Nat Commun 2019 Apr 17;10(1):1797. Epub 2019 Apr 17.

Department of Chemistry, Imperial College London, Exhibition Road, London, SW7 2AZ, UK.

The identification of short nucleic acids and proteins at the single molecule level is a major driving force for the development of novel detection strategies. Nanopore sensing has been gaining in prominence due to its label-free operation and single molecule sensitivity. However, it remains challenging to detect small molecules selectively. Read More

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http://www.nature.com/articles/s41467-019-09476-4
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http://dx.doi.org/10.1038/s41467-019-09476-4DOI Listing
April 2019
1 Read

Macaque dorsal premotor cortex exhibits decision-related activity only when specific stimulus-response associations are known.

Nat Commun 2019 Apr 17;10(1):1793. Epub 2019 Apr 17.

Département de Neurosciences, Pavillon Paul-G.-Desmarais, Faculté de Médecine, Université de Montréal, succursale Centre-ville, Montréal, QC, H3C 3J7, Canada.

How deliberation on sensory cues and action selection interact in decision-related brain areas is still not well understood. Here, monkeys reached to one of two targets, whose colors alternated randomly between trials, by discriminating the dominant color of a checkerboard cue composed of different numbers of squares of the two target colors in different trials. In a Targets First task the colored targets appeared first, followed by the checkerboard; in a Checkerboard First task, this order was reversed. Read More

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http://dx.doi.org/10.1038/s41467-019-09460-yDOI Listing

Multi-platform discovery of haplotype-resolved structural variation in human genomes.

Nat Commun 2019 Apr 16;10(1):1784. Epub 2019 Apr 16.

The Jackson Laboratory for Genomic Medicine, Farmington, CT, 06032, USA.

The incomplete identification of structural variants (SVs) from whole-genome sequencing data limits studies of human genetic diversity and disease association. Here, we apply a suite of long-read, short-read, strand-specific sequencing technologies, optical mapping, and variant discovery algorithms to comprehensively analyze three trios to define the full spectrum of human genetic variation in a haplotype-resolved manner. We identify 818,054 indel variants (<50 bp) and 27,622 SVs (≥50 bp) per genome. Read More

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http://www.nature.com/articles/s41467-018-08148-z
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http://dx.doi.org/10.1038/s41467-018-08148-zDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6467913PMC
April 2019
3 Reads

Biosynthesis of DHGA and its roles in Arabidopsis seedling establishment.

Nat Commun 2019 Apr 16;10(1):1768. Epub 2019 Apr 16.

Key Laboratory of Plant Stress Biology, School of Life Sciences, Henan University, 475004, Kaifeng, China.

Seed germination and photoautotrophic establishment are controlled by the antagonistic activity of the phytohormones gibberellins (GAs) and abscisic acid (ABA). Here we show that Arabidopsis thaliana GAS2 (Gain of Function in ABA-modulated Seed Germination 2), a protein belonging to the Fe-dependent 2-oxoglutarate dioxygenase superfamily, catalyzes the stereospecific hydration of GA to produce GA 16, 17-dihydro-16α-ol (DHGA). We show that DHGA, a C-GA has an atypical structure compared to known active GAs but can bind to the GA receptor (GID1c). Read More

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http://dx.doi.org/10.1038/s41467-019-09467-5DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6467921PMC

Phenotyping ciliary dynamics and coordination in response to CFTR-modulators in Cystic Fibrosis respiratory epithelial cells.

Nat Commun 2019 Apr 16;10(1):1763. Epub 2019 Apr 16.

Biological and Soft Systems Sector, Cavendish Laboratory, University of Cambridge, Cambridge, CB3 0HE, UK.

Personalized approaches for systematically assessing ciliary beat dynamics and for drug testing would improve the challenging task of diagnosing and treating respiratory disorders. In this pilot study, we show how multiscale differential dynamic microscopy (multi-DDM) can be used to characterize collective ciliary beating in a non-biased automated manner. We use multi-DDM to assess the efficacy of different CFTR-modulating drugs in human airway epithelial cells derived from subjects with cystic fibrosis (ΔF508/ΔF508 and ∆F508/-) based on ciliary beat frequency and coordination. Read More

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http://www.nature.com/articles/s41467-019-09798-3
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http://dx.doi.org/10.1038/s41467-019-09798-3DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6467870PMC
April 2019
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Publisher Correction: NRG1 type I dependent autoparacrine stimulation of Schwann cells in onion bulbs of peripheral neuropathies.

Nat Commun 2019 Apr 16;10(1):1840. Epub 2019 Apr 16.

Department of Neurogenetics, Max-Planck-Institute of Experimental Medicine, Hermann-Rein-Str. 3, 37075, Göttingen, Germany.

Michael W. Sereda was incorrectly associated with the Department of Cellular Neurophysiology, Hanover Medical School, Carl-Neuberg-Str. 1, 30625 Hanover, Germany. Read More

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http://dx.doi.org/10.1038/s41467-019-09886-4DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6467885PMC

Microfluidic multipoles theory and applications.

Nat Commun 2019 Apr 16;10(1):1781. Epub 2019 Apr 16.

Institut de Génie Biomédical, École Polytechnique de Montréal, Montréal, QC, H3T 1J4, Canada.

Microfluidic multipoles (MFMs) have been realized experimentally and hold promise for "open-space" biological and chemical surface processing. Whereas convective flow can readily be predicted using hydraulic-electrical analogies, the design of advanced microfluidic multipole is constrained by the lack of simple, accurate models to predict mass transport within them. In this work, we introduce the complete solutions to mass transport in multipolar microfluidics based on the iterative conformal mapping of 2D advection-diffusion around a simple edge into dipoles and multipolar geometries, revealing a rich landscape of transport modes. Read More

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http://dx.doi.org/10.1038/s41467-019-09740-7DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6467910PMC

Polygenic prediction via Bayesian regression and continuous shrinkage priors.

Nat Commun 2019 Apr 16;10(1):1776. Epub 2019 Apr 16.

Psychiatric and Neurodevelopmental Genetics Unit, Center for Genomic Medicine, Massachusetts General Hospital, Boston, MA, 02114, USA.

Polygenic risk scores (PRS) have shown promise in predicting human complex traits and diseases. Here, we present PRS-CS, a polygenic prediction method that infers posterior effect sizes of single nucleotide polymorphisms (SNPs) using genome-wide association summary statistics and an external linkage disequilibrium (LD) reference panel. PRS-CS utilizes a high-dimensional Bayesian regression framework, and is distinct from previous work by placing a continuous shrinkage (CS) prior on SNP effect sizes, which is robust to varying genetic architectures, provides substantial computational advantages, and enables multivariate modeling of local LD patterns. Read More

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http://dx.doi.org/10.1038/s41467-019-09718-5DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6467998PMC

Chiral acid-catalysed enantioselective C-H functionalization of toluene and its derivatives driven by visible light.

Nat Commun 2019 Apr 16;10(1):1774. Epub 2019 Apr 16.

Key Laboratory of Natural Medicine and Immuno-Engineering of Henan Province, Henan University, 475004, Kaifeng, Henan, China.

Toluene and its derivatives are petroleum-derived raw materials produced from gasoline by catalytic reformation. These abundant chemical feedstocks are commonly used as solvents in organic synthesis. The C(sp)-H functionalization of these unactivated substrates has been widely used to directly introduce benzylic motifs into diverse molecules to furnish important compounds. Read More

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http://dx.doi.org/10.1038/s41467-019-09857-9DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6467922PMC

Generation of spatiotemporally tailored terahertz wavepackets by nonlinear metasurfaces.

Nat Commun 2019 Apr 16;10(1):1778. Epub 2019 Apr 16.

Department of Physical Electronics, School of Electrical Engineering, Tel-Aviv University, 6997801, Tel Aviv, Israel.

The past two decades have witnessed an ever-growing number of emerging applications that utilize terahertz (THz) waves, ranging from advanced biomedical imaging, through novel security applications, fast wireless communications, and new abilities to study and control matter in all of its phases. The development and deployment of these emerging technologies is however held back, due to a substantial lack of simple methods for efficient generation, detection and manipulation of THz waves. Recently it was shown that uniform nonlinear metasurfaces can efficiently generate broadband single-cycle THz pulses. Read More

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http://dx.doi.org/10.1038/s41467-019-09811-9DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6467996PMC

Learning about climate change uncertainty enables flexible water infrastructure planning.

Nat Commun 2019 Apr 16;10(1):1782. Epub 2019 Apr 16.

Joint Program on the Science and Policy of Global Change, Massachusetts Institute of Technology, 77 Massachusetts Avenue, E19-411, Cambridge, MA, 02139, USA.

Water resources planning requires decision-making about infrastructure development under uncertainty in future regional climate conditions. However, uncertainty in climate change projections will evolve over the 100-year lifetime of a dam as new climate observations become available. Flexible strategies in which infrastructure is proactively designed to be changed in the future have the potential to meet water supply needs without expensive over-building. Read More

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http://www.nature.com/articles/s41467-019-09677-x
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http://dx.doi.org/10.1038/s41467-019-09677-xDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6468001PMC
April 2019
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Microbial and metabolic succession on common building materials under high humidity conditions.

Nat Commun 2019 Apr 16;10(1):1767. Epub 2019 Apr 16.

Department of Pediatrics and Scripps Institution of Oceanography, University of California San Diego, La Jolla, CA, 92037, USA.

Despite considerable efforts to characterize the microbial ecology of the built environment, the metabolic mechanisms underpinning microbial colonization and successional dynamics remain unclear, particularly at high moisture conditions. Here, we applied bacterial/viral particle counting, qPCR, amplicon sequencing of the genes encoding 16S and ITS rRNA, and metabolomics to longitudinally characterize the ecological dynamics of four common building materials maintained at high humidity. We varied the natural inoculum provided to each material and wet half of the samples to simulate a potable water leak. Read More

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http://dx.doi.org/10.1038/s41467-019-09764-zDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6467912PMC

Sexual selection predicts the rate and direction of colour divergence in a large avian radiation.

Nat Commun 2019 Apr 16;10(1):1773. Epub 2019 Apr 16.

Department of Animal and Plant Sciences, University of Sheffield, Western Bank, Sheffield, S10 2TN, UK.

Sexual selection is proposed to be a powerful driver of phenotypic evolution in animal systems. At macroevolutionary scales, sexual selection can theoretically drive both the rate and direction of phenotypic evolution, but this hypothesis remains contentious. Here, we find that differences in the rate and direction of plumage colour evolution are predicted by a proxy for sexual selection intensity (plumage dichromatism) in a large radiation of suboscine passerine birds (Tyrannida). Read More

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http://dx.doi.org/10.1038/s41467-019-09859-7DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6467902PMC

Enzymatic synthesis of lignin derivable pyridine based polyesters for the substitution of petroleum derived plastics.

Nat Commun 2019 Apr 16;10(1):1762. Epub 2019 Apr 16.

The University of York, Department of Chemistry, Green Chemistry Centre of Excellence, YO10 5DD, Heslington, York, UK.

Following concerns over increasing global plastic pollution, interest in the production and characterization of bio-based and biodegradable alternatives is rising. In the present work, the synthesis of a series of fully bio-based alternatives based on 2,4-, 2,5-, and 2,6-pyridinedicarboxylic acid-derived polymers produced via enzymatic catalysis are reported. A similar series of aromatic-aliphatic polyesters based on diethyl-2,5-furandicarboxylate and of the petroleum-based diethyl terephthalate and diethyl isophthalate were also synthesized. Read More

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http://dx.doi.org/10.1038/s41467-019-09817-3DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6467960PMC

All-optical control of lead halide perovskite microlasers.

Nat Commun 2019 Apr 16;10(1):1770. Epub 2019 Apr 16.

State Key Laboratory on Tunable laser Technology, Ministry of Industry and Information Technology Key Lab of Micro-Nano Optoelectronic Information System, Shenzhen Graduate School, Harbin Institute of Technology, Shenzhen, 518055, China.

Lead halide perovskites based microlasers have recently shown their potential in nanophotonics. However, up to now, all of the perovskite microlasers are static and cannot be dynamically tuned in use. Herein, we demonstrate a robust mechanism to realize the all-optical control of perovskite microlasers. Read More

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http://dx.doi.org/10.1038/s41467-019-09876-6DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6467983PMC

Selective photoelectrochemical oxidation of glycerol to high value-added dihydroxyacetone.

Nat Commun 2019 Apr 16;10(1):1779. Epub 2019 Apr 16.

School of Chemical and Biomedical Engineering, Nanyang Technological University, 62 Nanyang Drive, Singapore, 637459, Singapore.

It is highly profitable to transform glycerol - the main by-product from biodiesel production to high value-added chemicals. In this work, we develop a photoelectrochemical system based on nanoporous BiVO for selective oxidation of glycerol to 1,3-dihydroxyacetone - one of the most valuable derivatives of glycerol. Under AM 1. Read More

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http://www.nature.com/articles/s41467-019-09788-5
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http://dx.doi.org/10.1038/s41467-019-09788-5DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6467901PMC
April 2019
1 Read