114,119 results match your criteria Nature[Journal]


Author Correction: Inference of ecological and social drivers of human brain-size evolution.

Nature 2019 Feb 21. Epub 2019 Feb 21.

School of Biology, University of St Andrews, St Andrews, UK.

In the Acknowledgements section of this Letter, the words "M.G.-F. Read More

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http://dx.doi.org/10.1038/s41586-019-0950-8DOI Listing
February 2019

Space-junk spear, depression drug and the EU's digital copyright.

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Nature 2019 Feb;566(7744):300-301

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http://dx.doi.org/10.1038/d41586-019-00614-yDOI Listing
February 2019

This Nigerian doctor might just prevent the next deadly pandemic.

Authors:
Amy Maxmen

Nature 2019 Feb;566(7744):310-313

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http://dx.doi.org/10.1038/d41586-019-00615-xDOI Listing
February 2019

Gifts of Prometheus.

Authors:
Alex Shvartsman

Nature 2019 Feb;566(7744):420

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http://dx.doi.org/10.1038/d41586-019-00618-8DOI Listing
February 2019

A new moon for Neptune.

Authors:
Anne J Verbiscer

Nature 2019 Feb;566(7744):328-329

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http://dx.doi.org/10.1038/d41586-019-00576-1DOI Listing
February 2019

Why neutrons and protons are modified inside nuclei.

Authors:
Gerald Feldman

Nature 2019 Feb;566(7744):332-333

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http://dx.doi.org/10.1038/d41586-019-00577-0DOI Listing
February 2019

How evolutionary theory guides policy.

Nature 2019 Feb;566(7744):322-323

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http://dx.doi.org/10.1038/d41586-019-00605-zDOI Listing
February 2019

Modified structure of protons and neutrons in correlated pairs.

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Nature 2019 Feb 20;566(7744):354-358. Epub 2019 Feb 20.

The atomic nucleus is made of protons and neutrons (nucleons), which are themselves composed of quarks and gluons. Understanding how the quark-gluon structure of a nucleon bound in an atomic nucleus is modified by the surrounding nucleons is an outstanding challenge. Although evidence for such modification-known as the EMC effect-was first observed over 35 years ago, there is still no generally accepted explanation for its cause. Read More

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http://dx.doi.org/10.1038/s41586-019-0925-9DOI Listing
February 2019

The seventh inner moon of Neptune.

Nature 2019 Feb 20;566(7744):350-353. Epub 2019 Feb 20.

SETI Institute, Mountain View, CA, USA.

During its 1989 flyby, the Voyager 2 spacecraft imaged six small moons of Neptune, all with orbits well interior to that of the large, retrograde moon Triton. Along with a set of nearby rings, these moons are probably younger than Neptune itself; they formed shortly after the capture of Triton and most of them have probably been fragmented multiple times by cometary impacts. Here we report Hubble Space Telescope observations of a seventh inner moon, Hippocamp. Read More

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http://dx.doi.org/10.1038/s41586-019-0909-9DOI Listing
February 2019

The centrosome protein AKNA regulates neurogenesis via microtubule organization.

Nature 2019 Feb 20. Epub 2019 Feb 20.

Institute of Stem Cell Research, Helmholtz Center Munich, German Research Center for Environmental Health, Munich, Germany.

The expansion of brain size is accompanied by a relative enlargement of the subventricular zone during development. Epithelial-like neural stem cells divide in the ventricular zone at the ventricles of the embryonic brain, self-renew and generate basal progenitors that delaminate and settle in the subventricular zone in enlarged brain regions. The length of time that cells stay in the subventricular zone is essential for controlling further amplification and fate determination. Read More

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http://dx.doi.org/10.1038/s41586-019-0962-4DOI Listing
February 2019

MHC class II proteins mediate cross-species entry of bat influenza viruses.

Nature 2019 Feb 20. Epub 2019 Feb 20.

Institute of Medical Virology, University of Zurich, Zurich, Switzerland.

Zoonotic influenza A viruses of avian origin can cause severe disease in individuals, or even global pandemics, and thus pose a threat to human populations. Waterfowl and shorebirds are believed to be the reservoir for all influenza A viruses, but this has recently been challenged by the identification of novel influenza A viruses in bats. The major bat influenza A virus envelope glycoprotein, haemagglutinin, does not bind the canonical influenza A virus receptor, sialic acid or any other glycan, despite its high sequence and structural homology with conventional haemagglutinins. Read More

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http://dx.doi.org/10.1038/s41586-019-0955-3DOI Listing
February 2019

β-Synuclein-reactive T cells induce autoimmune CNS grey matter degeneration.

Nature 2019 Feb 20. Epub 2019 Feb 20.

Institute for Neuroimmunology and Multiple Sclerosis Research, University Medical Center Göttingen, Göttingen, Germany.

The grey matter is a central target of pathological processes in neurodegenerative disorders such as Parkinson's and Alzheimer's diseases. The grey matter is often also affected in multiple sclerosis, an autoimmune disease of the central nervous system. The mechanisms that underlie grey matter inflammation and degeneration in multiple sclerosis are not well understood. Read More

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http://dx.doi.org/10.1038/s41586-019-0964-2DOI Listing
February 2019

The single-cell transcriptional landscape of mammalian organogenesis.

Nature 2019 Feb 20. Epub 2019 Feb 20.

Department of Genome Sciences, University of Washington, Seattle, WA, USA.

Mammalian organogenesis is a remarkable process. Within a short timeframe, the cells of the three germ layers transform into an embryo that includes most of the major internal and external organs. Here we investigate the transcriptional dynamics of mouse organogenesis at single-cell resolution. Read More

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http://dx.doi.org/10.1038/s41586-019-0969-xDOI Listing
February 2019

A single-cell molecular map of mouse gastrulation and early organogenesis.

Nature 2019 Feb 20. Epub 2019 Feb 20.

Department of Haematology, Cambridge Institute for Medical Research, University of Cambridge, Cambridge, UK.

Across the animal kingdom, gastrulation represents a key developmental event during which embryonic pluripotent cells diversify into lineage-specific precursors that will generate the adult organism. Here we report the transcriptional profiles of 116,312 single cells from mouse embryos collected at nine sequential time points ranging from 6.5 to 8. Read More

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http://dx.doi.org/10.1038/s41586-019-0933-9DOI Listing
February 2019

Bacterial cGAS-like enzymes synthesize diverse nucleotide signals.

Nature 2019 Feb 20. Epub 2019 Feb 20.

Department of Microbiology, Harvard Medical School, Boston, MA, USA.

Cyclic dinucleotides (CDNs) have central roles in bacterial homeostasis and virulence by acting as nucleotide second messengers. Bacterial CDNs also elicit immune responses during infection when they are detected by pattern-recognition receptors in animal cells. Here we perform a systematic biochemical screen for bacterial signalling nucleotides and discover a large family of cGAS/DncV-like nucleotidyltransferases (CD-NTases) that use both purine and pyrimidine nucleotides to synthesize a diverse range of CDNs. Read More

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http://dx.doi.org/10.1038/s41586-019-0953-5DOI Listing
February 2019

Neuromodulatory control of localized dendritic spiking in critical period cortex.

Nature 2019 Feb 20. Epub 2019 Feb 20.

Department of Neurobiology, David Geffen School of Medicine at UCLA, Los Angeles, CA, USA.

Sensory experience in early postnatal life, during so-called critical periods, restructures neural circuitry to enhance information processing. Why the cortex is susceptible to sensory instruction in early life and why this susceptibility wanes with age are unclear. Here we define a developmentally restricted engagement of inhibitory circuitry that shapes localized dendritic activity and is needed for vision to drive the emergence of binocular visual responses in the mouse primary visual cortex. Read More

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http://dx.doi.org/10.1038/s41586-019-0963-3DOI Listing
February 2019

Female-biased embryonic death from inflammation induced by genomic instability.

Nature 2019 Feb 20. Epub 2019 Feb 20.

Cornell University College of Veterinary Medicine, Department of Biomedical Sciences, Cornell University, Ithaca, NY, USA.

Genomic instability can trigger cellular responses that include checkpoint activation, senescence and inflammation. Although genomic instability has been extensively studied in cell culture and cancer paradigms, little is known about its effect during embryonic development, a period of rapid cellular proliferation. Here we report that mutations in the heterohexameric minichromosome maintenance complex-the DNA replicative helicase comprising MCM2 to MCM7-that cause genomic instability render female mouse embryos markedly more susceptible than males to embryonic lethality. Read More

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http://dx.doi.org/10.1038/s41586-019-0936-6DOI Listing
February 2019

From the archive.

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Nature 2019 Feb;566(7744):331

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http://dx.doi.org/10.1038/d41586-019-00627-7DOI Listing
February 2019

A disadvantaged background doesn't have to be a barrier to success.

Authors:
Virginia Gewin

Nature 2019 Feb;566(7744):415-417

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http://dx.doi.org/10.1038/d41586-019-00617-9DOI Listing
February 2019
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3D printing: don't add to plastic pollution.

Authors:
A Ravi P Rau

Nature 2019 Feb;566(7744):326

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http://dx.doi.org/10.1038/d41586-019-00623-xDOI Listing
February 2019

African swine fever could cause EU rift.

Nature 2019 Feb;566(7744):326

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http://dx.doi.org/10.1038/d41586-019-00621-zDOI Listing
February 2019

Groundwater-management plans - how well will they work?

Authors:
Emma K White

Nature 2019 Feb;566(7744):326

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http://dx.doi.org/10.1038/d41586-019-00620-0DOI Listing
February 2019

3D-printed lab parts can contaminate experiments.

Authors:
Pawel Urban

Nature 2019 Feb;566(7744):326

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http://dx.doi.org/10.1038/d41586-019-00622-yDOI Listing
February 2019

Baby's mouth might hold sway over breast-milk microbiome.

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Nature 2019 Feb;566(7744):299

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http://dx.doi.org/10.1038/d41586-019-00568-1DOI Listing
February 2019

A young star is sprinkled with table salt.

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Nature 2019 Feb;566(7744):299

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http://dx.doi.org/10.1038/d41586-019-00569-0DOI Listing
February 2019

Hungary's scientists outraged by government budget grab.

Authors:
Alison Abbott

Nature 2019 Feb;566(7744):306-307

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http://dx.doi.org/10.1038/d41586-019-00586-zDOI Listing
February 2019

The vaporized rock and extreme heat at a huge landslide's heart.

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Nature 2019 Feb;566(7744):299

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http://dx.doi.org/10.1038/d41586-019-00536-9DOI Listing
February 2019

High-flying pseudosatellites get their day in the sun.

Authors:
Alexandra Witze

Nature 2019 Feb;566(7744):308-309

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http://dx.doi.org/10.1038/d41586-019-00561-8DOI Listing
February 2019

Young bats rely on Mum for real-estate advice.

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Nature 2019 Feb;566(7744):298

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http://dx.doi.org/10.1038/d41586-019-00544-9DOI Listing
February 2019

Violent drug cartels stifle Mexican science.

Nature 2019 Feb;566(7744):303-304

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http://dx.doi.org/10.1038/d41586-019-00458-6DOI Listing
February 2019

Nano-device maps a cell's enzymes at work.

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Nature 2019 Feb;566(7744):299

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http://dx.doi.org/10.1038/d41586-019-00533-yDOI Listing
February 2019

Earth's green patches become greener - and China is leading the way.

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Nature 2019 Feb;566(7744):298

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http://dx.doi.org/10.1038/d41586-019-00537-8DOI Listing
February 2019

Biological clues to an enigmatic treatment for traumatic stress.

Authors:
Andrew Holmes

Nature 2019 Feb;566(7744):335-336

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http://dx.doi.org/10.1038/d41586-019-00294-8DOI Listing
February 2019

How broken sleep promotes cardiovascular disease.

Nature 2019 Feb;566(7744):329-330

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http://dx.doi.org/10.1038/d41586-019-00393-6DOI Listing
February 2019

Pain was sharp but short for ancient 'bog body' victims.

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Nature 2019 Feb;566(7744):298

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http://dx.doi.org/10.1038/d41586-019-00534-xDOI Listing
February 2019

Photonic topological insulator in synthetic dimensions.

Nature 2019 Feb 18. Epub 2019 Feb 18.

Physics Department and Solid State Institute, Technion-Israel Institute of Technology, Haifa, Israel.

Topological phases enable protected transport along the edges of materials, offering immunity against scattering from disorder and imperfections. These phases have been demonstrated for electronic systems, electromagnetic waves, cold atoms, acoustics and even mechanics, and their potential applications include spintronics, quantum computing and highly efficient lasers. Typically, the model describing topological insulators is a spatial lattice in two or three dimensions. Read More

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http://dx.doi.org/10.1038/s41586-019-0943-7DOI Listing
February 2019

Multiplex chromatin interactions with single-molecule precision.

Nature 2019 Feb 18. Epub 2019 Feb 18.

The Jackson Laboratory for Genomic Medicine, Farmington, CT, USA.

The genomes of multicellular organisms are extensively folded into 3D chromosome territories within the nucleus. Advanced 3D genome-mapping methods that combine proximity ligation and high-throughput sequencing (such as chromosome conformation capture, Hi-C), and chromatin immunoprecipitation techniques (such as chromatin interaction analysis by paired-end tag sequencing, ChIA-PET), have revealed topologically associating domains with frequent chromatin contacts, and have identified chromatin loops mediated by specific protein factors for insulation and regulation of transcription. However, these methods rely on pairwise proximity ligation and reflect population-level views, and thus cannot reveal the detailed nature of chromatin interactions. Read More

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http://www.nature.com/articles/s41586-019-0949-1
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http://dx.doi.org/10.1038/s41586-019-0949-1DOI Listing
February 2019
6 Reads