113,672 results match your criteria Nature[Journal]


2018: Choice cuts from this year's News & Views articles.

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Nature 2018 12;564(7736):356-357

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December 2018
3 Reads

Transmission of amyloid-β protein pathology from cadaveric pituitary growth hormone.

Nature 2018 Dec 13. Epub 2018 Dec 13.

MRC Prion Unit at UCL, UCL Institute of Prion Diseases, London, UK.

We previously reported the presence of amyloid-β protein (Aβ) deposits in individuals with Creutzfeldt-Jakob disease (CJD) who had been treated during childhood with human cadaveric pituitary-derived growth hormone (c-hGH) contaminated with prions. The marked deposition of parenchymal and vascular Aβ in these relatively young individuals with treatment-induced (iatrogenic) CJD (iCJD), in contrast to other prion-disease patients and population controls, allied with the ability of Alzheimer's disease brain homogenates to seed Aβ deposition in laboratory animals, led us to argue that the implicated c-hGH batches might have been contaminated with Aβ seeds as well as with prions. However, this was necessarily an association, and not an experimental, study in humans and causality could not be concluded. Read More

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December 2018
12 Reads

A guide to the Nature Index.

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Nature 2018 Dec;564(7735):S73

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December 2018

The genetic shortcut to antibody drugs.

Authors:
Amanda Keener

Nature 2018 Dec;564(7735):S16-S17

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December 2018

All eyes on the prize.

Nature 2018 Dec;564(7735):S57

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December 2018

China's place among the stars.

Authors:
Mark Zastrow

Nature 2018 Dec;564(7735):S64-S65

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December 2018

Yielding results to feed a people.

Authors:
Hepeng Jia

Nature 2018 Dec;564(7735):S62-S63

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December 2018

Small science grows large in new hands.

Authors:
Sarah O'Meara

Nature 2018 Dec;564(7735):S65-S66

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December 2018

Gene therapy.

Authors:
Herb Brody

Nature 2018 Dec;564(7735):S5

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December 2018

Engineering a biomedical revolution.

Authors:
Smriti Mallapaty

Nature 2018 Dec;564(7735):S66-S68

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December 2018

Change the genes to fix the skin.

Authors:
Kat Arney

Nature 2018 Dec;564(7735):S14-S15

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December 2018

Quality deficit belies the hype.

Authors:
Futao Huang

Nature 2018 Dec;564(7735):S70-S71

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December 2018

Strong spending compounds chemistry prowess.

Authors:
Hepeng Jia

Nature 2018 Dec;564(7735):S68-S69

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December 2018

Regulating the gene-therapy revolution.

Authors:
Eric Bender

Nature 2018 Dec;564(7735):S20-S22

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December 2018

How Indian biotech is driving innovation.

Authors:
Bianca Nogrady

Nature 2018 Dec;564(7735):S53-S55

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December 2018

Gene therapy targets sickle-cell disease.

Authors:
Anna Nowogrodzki

Nature 2018 Dec;564(7735):S12-S13

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December 2018
2 Reads

Gene therapy targets epilepsy.

Authors:
Liam Drew

Nature 2018 Dec;564(7735):S10-S11

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December 2018

Access and affordability for all.

Authors:
Michael Sherman

Nature 2018 Dec;564(7735):S23

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December 2018

The hunt for life below Antarctic ice.

Authors:
Douglas Fox

Nature 2018 12;564(7735):180-182

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December 2018

NIH dollars go to too few US states.

Authors:
Wayne P Wahls

Nature 2018 12;564(7735):190

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December 2018

Assessing the efficiency of changes in land use for mitigating climate change.

Nature 2018 12 12;564(7735):249-253. Epub 2018 Dec 12.

Centre International de Recherche sur l'Environnement et le Développement (CIRED), Montpelier, France.

Land-use changes are critical for climate policy because native vegetation and soils store abundant carbon and their losses from agricultural expansion, together with emissions from agricultural production, contribute about 20 to 25 per cent of greenhouse gas emissions. Most climate strategies require maintaining or increasing land-based carbon while meeting food demands, which are expected to grow by more than 50 per cent by 2050. A finite global land area implies that fulfilling these strategies requires increasing global land-use efficiency of both storing carbon and producing food. Read More

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December 2018

Cold heart.

Authors:
Victoria Dixon

Nature 2018 12;564(7735):296

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December 2018

Experimental realization of on-chip topological nanoelectromechanical metamaterials.

Nature 2018 12 12;564(7735):229-233. Epub 2018 Dec 12.

Engineering and Applied Science, California Institute of Technology, Pasadena, CA, USA.

Guiding waves through a stable physical channel is essential for reliable information transport. However, energy transport in high-frequency mechanical systems, such as in signal-processing applications, is particularly sensitive to defects and sharp turns because of back-scattering and losses. Topological phenomena in condensed matter systems have shown immunity to defects and unidirectional energy propagation. Read More

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December 2018
1 Read

Increased variability of eastern Pacific El Niño under greenhouse warming.

Nature 2018 12 12;564(7735):201-206. Epub 2018 Dec 12.

NOAA/Pacific Marine Environmental Laboratory, Seattle, WA, USA.

The El Niño-Southern Oscillation (ENSO) is the dominant and most consequential climate variation on Earth, and is characterized by warming of equatorial Pacific sea surface temperatures (SSTs) during the El Niño phase and cooling during the La Niña phase. ENSO events tend to have a centre-corresponding to the location of the maximum SST anomaly-in either the central equatorial Pacific (5° S-5° N, 160° E-150° W) or the eastern equatorial Pacific (5° S-5° N, 150°-90° W); these two distinct types of ENSO event are referred to as the CP-ENSO and EP-ENSO regimes, respectively. How the ENSO may change under future greenhouse warming is unknown, owing to a lack of inter-model agreement over the response of SSTs in the eastern equatorial Pacific to such warming. Read More

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December 2018

An entanglement-based wavelength-multiplexed quantum communication network.

Nature 2018 12 12;564(7735):225-228. Epub 2018 Dec 12.

Institute for Quantum Optics and Quantum Information-Vienna, Austrian Academy of Sciences, Vienna, Austria.

Quantum key distribution has reached the level of maturity required for deployment in real-world scenarios. It has previously been shown to operate alongside classical communication in the same telecommunication fibre and over long distances in fibre and in free-space links. Despite these advances, the practical applicability of quantum key distribution is curtailed by the fact that most implementations and protocols are limited to two communicating parties. Read More

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December 2018

Disruption of a self-amplifying catecholamine loop reduces cytokine release syndrome.

Nature 2018 12 12;564(7735):273-277. Epub 2018 Dec 12.

Ludwig Center and the Howard Hughes Medical Institute at the Johns Hopkins Kimmel Cancer Center, Baltimore, MD, USA.

Cytokine release syndrome (CRS) is a life-threatening complication of several new immunotherapies used to treat cancers and autoimmune diseases. Here we report that atrial natriuretic peptide can protect mice from CRS induced by such agents by reducing the levels of circulating catecholamines. Catecholamines were found to orchestrate an immunodysregulation resulting from oncolytic bacteria and lipopolysaccharide through a self-amplifying loop in macrophages. Read More

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December 2018

Catalytic deracemization of chiral allenes by sensitized excitation with visible light.

Nature 2018 12 12;564(7735):240-243. Epub 2018 Dec 12.

Department Chemie and Catalysis Research Center (CRC), Technische Universität München, Garching, Germany.

Chiral compounds exist as enantiomers that are non-superimposable mirror images of each other. Owing to the importance of enantiomerically pure chiral compounds-for example, as active pharmaceutical ingredients-separation of racemates (1:1 mixtures of enantiomers) is extensively performed. Frequently, however, only a single enantiomeric form of a chiral compound is required, which raises the question of how a racemate can be selectively converted into a single enantiomer. Read More

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December 2018

Structural basis of coreceptor recognition by HIV-1 envelope spike.

Nature 2018 Dec 12. Epub 2018 Dec 12.

Division of Molecular Medicine, Boston Children's Hospital, Harvard Medical School, Boston, MA, USA.

HIV-1 envelope glycoprotein (Env), which consists of trimeric (gp160) cleaved to (gp120 and gp41), interacts with the primary receptor CD4 and a coreceptor (such as chemokine receptor CCR5) to fuse viral and target-cell membranes. The gp120-coreceptor interaction has previously been proposed as the most crucial trigger for unleashing the fusogenic potential of gp41. Here we report a cryo-electron microscopy structure of a full-length gp120 in complex with soluble CD4 and unmodified human CCR5, at 3. Read More

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December 2018

A male-expressed rice embryogenic trigger redirected for asexual propagation through seeds.

Nature 2018 Dec 12. Epub 2018 Dec 12.

Department of Plant Biology, University of California, Davis, CA, USA.

The molecular pathways that trigger the initiation of embryogenesis after fertilization in flowering plants, and prevent its occurrence without fertilization, are not well understood. Here we show in rice (Oryza sativa) that BABY BOOM1 (BBM1), a member of the AP2 family of transcription factors that is expressed in sperm cells, has a key role in this process. Ectopic expression of BBM1 in the egg cell is sufficient for parthenogenesis, which indicates that a single wild-type gene can bypass the fertilization checkpoint in the female gamete. Read More

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December 2018
42.351 Impact Factor

Structure of Plasmodium falciparum Rh5-CyRPA-Ripr invasion complex.

Nature 2018 Dec 12. Epub 2018 Dec 12.

Walter and Eliza Hall Institute of Medical Research, Parkville, Victoria, Australia.

Plasmodium falciparum causes the severe form of malaria that has high levels of mortality in humans. Blood-stage merozoites of P. falciparum invade erythrocytes, and this requires interactions between multiple ligands from the parasite and receptors in hosts. Read More

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December 2018
2 Reads
42.351 Impact Factor

Direct observation of incommensurate magnetism in Hubbard chains.

Nature 2018 Dec 12. Epub 2018 Dec 12.

Fakultät für Physik, Ludwig-Maximilians-Universität, Munich, Germany.

The interplay between magnetism and doping is at the origin of exotic strongly correlated electronic phases and can lead to novel forms of magnetic ordering. One example is the emergence of incommensurate spin-density waves, which have wavevectors that do not belong to the reciprocal lattice. In one dimension this effect is a hallmark of Luttinger liquid theory, which also describes the low-energy physics of the Hubbard model. Read More

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December 2018

Structure of native lens connexin 46/50 intercellular channels by cryo-EM.

Nature 2018 Dec 12. Epub 2018 Dec 12.

Department of Chemistry, Portland State University, Portland, OR, USA.

Gap junctions establish direct pathways for cell-to-cell communication through the assembly of twelve connexin subunits that form intercellular channels connecting neighbouring cells. Co-assembly of different connexin isoforms produces channels with unique properties and enables communication across cell types. Here we used single-particle cryo-electron microscopy to investigate the structural basis of connexin co-assembly in native lens gap junction channels composed of connexin 46 and connexin 50 (Cx46/50). Read More

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December 2018

Trapping biosynthetic acyl-enzyme intermediates with encoded 2,3-diaminopropionic acid.

Nature 2018 Dec 12. Epub 2018 Dec 12.

Medical Research Council Laboratory of Molecular Biology, Cambridge, UK.

Many enzymes catalyse reactions that proceed through covalent acyl-enzyme (ester or thioester) intermediates. These enzymes include serine hydrolases (encoded by one per cent of human genes, and including serine proteases and thioesterases), cysteine proteases (including caspases), and many components of the ubiquitination machinery. Their important acyl-enzyme intermediates are unstable, commonly having half-lives of minutes to hours. Read More

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December 2018

The translation of non-canonical open reading frames controls mucosal immunity.

Nature 2018 Dec 12. Epub 2018 Dec 12.

Department of Immunobiology, Yale University School of Medicine, New Haven, CT, USA.

The annotation of the mammalian protein-coding genome is incomplete. Arbitrary size restriction of open reading frames (ORFs) and the absolute requirement for a methionine codon as the sole initiator of translation have constrained the identification of potentially important transcripts with non-canonical protein-coding potential. Here, using unbiased transcriptomic approaches in macrophages that respond to bacterial infection, we show that ribosomes associate with a large number of RNAs that were previously annotated as 'non-protein coding'. Read More

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December 2018

Aaron Klug (1926-2018).

Authors:
Kenneth Holmes

Nature 2018 12;564(7736):346

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December 2018