114,603 results match your criteria Nature[Journal]


Publisher Correction: Martian dust storm impact on atmospheric HO and D/H observed by ExoMars Trace Gas Orbiter.

Nature 2019 Apr 17. Epub 2019 Apr 17.

Space Research Institute (IKI), Russian Academy of Sciences (RAS), Moscow, Russia.

The surname of author Cathy Quantin-Nataf was misspelled 'Quantin-Nata' , authors Ehouarn Millour and Roland Young were missing from the ACS Science Team list, and minor changes have been made to the author and affiliation lists; see accompanying Amendment. These errors have been corrected online. Read More

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http://dx.doi.org/10.1038/s41586-019-1163-xDOI Listing

Targeting LIF-mediated paracrine interaction for pancreatic cancer therapy and monitoring.

Nature 2019 Apr 17. Epub 2019 Apr 17.

Molecular and Cell Biology Laboratory, Salk Institute for Biological Studies, La Jolla, CA, USA.

Pancreatic ductal adenocarcinoma (PDAC) has a dismal prognosis largely owing to inefficient diagnosis and tenacious drug resistance. Activation of pancreatic stellate cells (PSCs) and consequent development of dense stroma are prominent features accounting for this aggressive biology. The reciprocal interplay between PSCs and pancreatic cancer cells (PCCs) not only enhances tumour progression and metastasis but also sustains their own activation, facilitating a vicious cycle to exacerbate tumorigenesis and drug resistance. Read More

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http://dx.doi.org/10.1038/s41586-019-1130-6DOI Listing

Neurocranial development of the coelacanth and the evolution of the sarcopterygian head.

Nature 2019 Apr 17. Epub 2019 Apr 17.

UMR 7179 (MNHN-CNRS) MECADEV, Département Adaptations du Vivant, Muséum National d'Histoire Naturelle, Paris, France.

The neurocranium of sarcopterygian fishes was originally divided into an anterior (ethmosphenoid) and posterior (otoccipital) portion by an intracranial joint, and underwent major changes in its overall geometry before fusing into a single unit in lungfishes and early tetrapods. Although the pattern of these changes is well-documented, the developmental mechanisms that underpin variation in the form of the neurocranium and its associated soft tissues during the evolution of sarcopterygian fishes remain poorly understood. The coelacanth Latimeria is the only known living vertebrate that retains an intracranial joint. Read More

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http://www.nature.com/articles/s41586-019-1117-3
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http://dx.doi.org/10.1038/s41586-019-1117-3DOI Listing
April 2019
1 Read

Predicting disruptive instabilities in controlled fusion plasmas through deep learning.

Nature 2019 Apr 17. Epub 2019 Apr 17.

Princeton Plasma Physics Laboratory, Princeton, NJ, USA.

Nuclear fusion power delivered by magnetic-confinement tokamak reactors holds the promise of sustainable and clean energy. The avoidance of large-scale plasma instabilities called disruptions within these reactors is one of the most pressing challenges, because disruptions can halt power production and damage key components. Disruptions are particularly harmful for large burning-plasma systems such as the multibillion-dollar International Thermonuclear Experimental Reactor (ITER) project currently under construction, which aims to be the first reactor that produces more power from fusion than is injected to heat the plasma. Read More

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http://dx.doi.org/10.1038/s41586-019-1116-4DOI Listing

Mammalian ISWI and SWI/SNF selectively mediate binding of distinct transcription factors.

Nature 2019 Apr 17. Epub 2019 Apr 17.

Friedrich Miescher Institute for Biomedical Research, Basel, Switzerland.

Chromatin remodelling complexes evict, slide, insert or replace nucleosomes, which represent an intrinsic barrier for access to DNA. These remodellers function in most aspects of genome utilization including transcription-factor binding, DNA replication and repair. Although they are frequently mutated in cancer, it remains largely unclear how the four mammalian remodeller families (SWI/SNF, ISWI, CHD and INO80) orchestrate the global organization of nucleosomes. Read More

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http://dx.doi.org/10.1038/s41586-019-1115-5DOI Listing

Fatty acid transport protein 2 reprograms neutrophils in cancer.

Nature 2019 Apr 17. Epub 2019 Apr 17.

Immunology, Microenvironment and Metastasis Program, The Wistar Institute, Philadelphia, PA, USA.

Polymorphonuclear myeloid-derived suppressor cells (PMN-MDSCs) are pathologically activated neutrophils that are crucial for the regulation of immune responses in cancer. These cells contribute to the failure of cancer therapies and are associated with poor clinical outcomes. Despite recent advances in the understanding of PMN-MDSC biology, the mechanisms responsible for the pathological activation of neutrophils are not well defined, and this limits the selective targeting of these cells. Read More

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http://dx.doi.org/10.1038/s41586-019-1118-2DOI Listing

LLGL2 rescues nutrient stress by promoting leucine uptake in ER breast cancer.

Nature 2019 Apr 17. Epub 2019 Apr 17.

Department of Medicine, Cancer Research Institute, Beth Israel Deaconess Medical Center, Harvard Medical School, Boston, MA, USA.

Drosophila Lgl and its mammalian homologues, LLGL1 and LLGL2, are scaffolding proteins that regulate the establishment of apical-basal polarity in epithelial cells. Whereas Lgl functions as a tumour suppressor in Drosophila, the roles of mammalian LLGL1 and LLGL2 in cancer are unclear. The majority (about 75%) of breast cancers express oestrogen receptors (ERs), and patients with these tumours receive endocrine treatment. Read More

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http://www.nature.com/articles/s41586-019-1126-2
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http://dx.doi.org/10.1038/s41586-019-1126-2DOI Listing
April 2019
1 Read

Astronaut twins, Nepal tornado and malaria vaccine.

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Nature 2019 Apr;568(7752):280-281

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http://www.nature.com/articles/d41586-019-01165-y
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http://dx.doi.org/10.1038/d41586-019-01165-yDOI Listing
April 2019
1 Read

Pig brains kept alive outside body for hours after death.

Authors:
Sara Reardon

Nature 2019 Apr;568(7752):283-284

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http://dx.doi.org/10.1038/d41586-019-01216-4DOI Listing

Observation of room-temperature polar skyrmions.

Nature 2019 Apr 17;568(7752):368-372. Epub 2019 Apr 17.

Department of Materials Science and Engineering, University of California, Berkeley, CA, USA.

Complex topological configurations are fertile ground for exploring emergent phenomena and exotic phases in condensed-matter physics. For example, the recent discovery of polarization vortices and their associated complex-phase coexistence and response under applied electric fields in superlattices of (PbTiO)/(SrTiO) suggests the presence of a complex, multi-dimensional system capable of interesting physical responses, such as chirality, negative capacitance and large piezo-electric responses. Here, by varying epitaxial constraints, we discover room-temperature polar-skyrmion bubbles in a lead titanate layer confined by strontium titanate layers, which are imaged by atomic-resolution scanning transmission electron microscopy. Read More

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http://dx.doi.org/10.1038/s41586-019-1092-8DOI Listing

Resonant electro-optic frequency comb.

Nature 2019 Apr 17;568(7752):378-381. Epub 2019 Apr 17.

The Dodd-Walls Centre for Photonic and Quantum Technologies, Dunedin, New Zealand.

High-speed optical telecommunication is enabled by wavelength-division multiplexing, whereby hundreds of individually stabilized lasers encode information within a single-mode optical fibre. Higher bandwidths require higher total optical power, but the power sent into the fibre is limited by optical nonlinearities within the fibre, and energy consumption by the light sources starts to become a substantial cost factor. Optical frequency combs have been suggested to remedy this problem by generating numerous discrete, equidistant laser lines within a monolithic device; however, at present their stability and coherence allow them to operate only within small parameter ranges. Read More

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http://dx.doi.org/10.1038/s41586-019-1110-xDOI Listing

Restoration of brain circulation and cellular functions hours post-mortem.

Nature 2019 Apr 17;568(7752):336-343. Epub 2019 Apr 17.

Department of Neuroscience, Yale School of Medicine, New Haven, CT, USA.

The brains of humans and other mammals are highly vulnerable to interruptions in blood flow and decreases in oxygen levels. Here we describe the restoration and maintenance of microcirculation and molecular and cellular functions of the intact pig brain under ex vivo normothermic conditions up to four hours post-mortem. We have developed an extracorporeal pulsatile-perfusion system and a haemoglobin-based, acellular, non-coagulative, echogenic, and cytoprotective perfusate that promotes recovery from anoxia, reduces reperfusion injury, prevents oedema, and metabolically supports the energy requirements of the brain. Read More

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http://www.nature.com/articles/s41586-019-1099-1
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http://dx.doi.org/10.1038/s41586-019-1099-1DOI Listing
April 2019
6 Reads

Multi-faceted particle pumps drive carbon sequestration in the ocean.

Nature 2019 Apr 17;568(7752):327-335. Epub 2019 Apr 17.

Department of Earth and Environmental Sciences, University of Rochester, Rochester, NY, USA.

The ocean's ability to sequester carbon away from the atmosphere exerts an important control on global climate. The biological pump drives carbon storage in the deep ocean and is thought to function via gravitational settling of organic particles from surface waters. However, the settling flux alone is often insufficient to balance mesopelagic carbon budgets or to meet the demands of subsurface biota. Read More

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http://www.nature.com/articles/s41586-019-1098-2
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http://dx.doi.org/10.1038/s41586-019-1098-2DOI Listing
April 2019
1 Read

Astrophysical detection of the helium hydride ion HeH.

Nature 2019 Apr 17;568(7752):357-359. Epub 2019 Apr 17.

I. Physikalisches Institut, Universität zu Köln, Cologne, Germany.

During the dawn of chemistry, when the temperature of the young Universe had fallen below some 4,000 kelvin, the ions of the light elements produced in Big Bang nucleosynthesis recombined in reverse order of their ionization potential. With their higher ionization potentials, the helium ions He and He were the first to combine with free electrons, forming the first neutral atoms; the recombination of hydrogen followed. In this metal-free and low-density environment, neutral helium atoms formed the Universe's first molecular bond in the helium hydride ion HeH through radiative association with protons. Read More

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http://www.nature.com/articles/s41586-019-1090-x
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http://dx.doi.org/10.1038/s41586-019-1090-xDOI Listing
April 2019
1 Read

Moon mapper, Sun spotter: the astonishing Thomas Harriot.

Authors:
Georgina Ferry

Nature 2019 Apr;568(7752):311-312

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http://dx.doi.org/10.1038/d41586-019-01174-xDOI Listing

Seven nations that survived apocalypse.

Authors:
Richard Rhodes

Nature 2019 Apr;568(7752):312-314

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http://dx.doi.org/10.1038/d41586-019-01175-wDOI Listing

Needle-like structures discovered on positively charged lightning branches.

Nature 2019 Apr 17;568(7752):360-363. Epub 2019 Apr 17.

ASTRON, Netherlands Institute for Radio Astronomy, Dwingeloo, The Netherlands.

Lightning is a dangerous yet poorly understood natural phenomenon. Lightning forms a network of plasma channels propagating away from the initiation point with both positively and negatively charged ends-called positive and negative leaders. Negative leaders propagate in discrete steps, emitting copious radio pulses in the 30-300-megahertz frequency band that can be remotely sensed and imaged with high spatial and temporal resolution. Read More

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http://dx.doi.org/10.1038/s41586-019-1086-6DOI Listing

Electrifying skyrmion bubbles.

Authors:
Pavlo Zubko

Nature 2019 Apr;568(7752):322-323

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http://dx.doi.org/10.1038/d41586-019-01139-0DOI Listing

The fast stuff.

Authors:
George Zebrowski

Nature 2019 Apr;568(7752):428

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http://dx.doi.org/10.1038/d41586-019-01180-zDOI Listing

Transcriptome-wide off-target RNA editing induced by CRISPR-guided DNA base editors.

Nature 2019 Apr 17. Epub 2019 Apr 17.

Molecular Pathology Unit, Massachusetts General Hospital, Charlestown, MA, USA.

CRISPR-Cas base editor technology enables targeted nucleotide alterations and is being rapidly deployed for research and potential therapeutic applications. The most widely used base editors induce DNA cytosine (C) deamination with rat APOBEC1 (rAPOBEC1) enzyme, which is targeted by a linked Cas protein-guide RNA (gRNA) complex. Previous studies of cytosine base editor (CBE) specificity have identified off-target DNA edits in human cells. Read More

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http://dx.doi.org/10.1038/s41586-019-1161-zDOI Listing
April 2019
5 Reads

Facing up to injustice in genome science.

Nature 2019 Apr;568(7752):290-293

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http://dx.doi.org/10.1038/d41586-019-01166-xDOI Listing

Three-year trial shows support for recognizing peer reviewers.

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Nature 2019 Apr;568(7752):275

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http://dx.doi.org/10.1038/d41586-019-01162-1DOI Listing

A struggle for the soul of theoretical physics.

Authors:
Jon Butterworth

Nature 2019 Apr;568(7752):309-311

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http://dx.doi.org/10.1038/d41586-019-01171-0DOI Listing

From the archive.

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Nature 2019 Apr;568(7752):323

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http://dx.doi.org/10.1038/d41586-019-01179-6DOI Listing

Compartmentalized gut lymph node drainage dictates adaptive immune responses.

Nature 2019 Apr 15. Epub 2019 Apr 15.

Laboratory of Mucosal Immunology, The Rockefeller University, New York, NY, USA.

The intestinal immune system has the challenging task of tolerating foreign nutrients and the commensal microbiome, while excluding or eliminating ingested pathogens. Failure of this balance leads to conditions such as inflammatory bowel diseases, food allergies and invasive gastrointestinal infections. Multiple immune mechanisms are therefore in place to maintain tissue integrity, including balanced generation of effector T (T) cells and FOXP3 regulatory T (pT) cells, which mediate resistance to pathogens and regulate excessive immune activation, respectively. Read More

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http://www.nature.com/articles/s41586-019-1125-3
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http://dx.doi.org/10.1038/s41586-019-1125-3DOI Listing
April 2019
2 Reads

The sorrows of psychiatry.

Authors:
Alison Abbott

Nature 2019 Apr;568(7752):314-315

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http://dx.doi.org/10.1038/d41586-019-01170-1DOI Listing

Einstein, Eddington and the 1919 eclipse.

Authors:
Peter Coles

Nature 2019 Apr;568(7752):306-307

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http://dx.doi.org/10.1038/d41586-019-01172-zDOI Listing

How to ensure a quantum key arrives on time.

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Nature 2019 Apr;568(7752):278

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http://dx.doi.org/10.1038/d41586-019-01148-zDOI Listing

A 102-year-old bacterial culture reveals a microbe's foul methods.

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Nature 2019 Apr;568(7752):279

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http://dx.doi.org/10.1038/d41586-019-01136-3DOI Listing
April 2019
1 Read

Gutless worms rely on handouts from internal microbes.

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Nature 2019 Apr;568(7752):278

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http://dx.doi.org/10.1038/d41586-019-01147-0DOI Listing

A rich British stout is dissected with a virtual 'scalpel'.

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Nature 2019 Apr;568(7752):279

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http://dx.doi.org/10.1038/d41586-019-01132-7DOI Listing

A jaunt by airborne 'car' can save on greenhouse gases.

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Nature 2019 Apr;568(7752):279

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http://dx.doi.org/10.1038/d41586-019-01135-4DOI Listing