3,541 results match your criteria Natural product communications[Journal]


Phytochemicals and Biological Activities of Laurel Tree (Laurus nobilis).

Nat Prod Commun 2017 May;12(5):743-757

This review summarizes the chemical composition reported up to date on Laurus nobilis L. (Lauraceae), an evergreen shrub or tree cultivated for its aromatic leaves and ornamental interest. It has been focused on non-volatile phytochemicals such as sesquiterpene lactones, flavonoids and proanthocyanidins, among others. Read More

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May 2017
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Occurrence and Chemical Synthesis of Apocarotenoids from Mucorales: A Review.

Nat Prod Commun 2017 May;12(5):733-741

Apocarotenoids are metabolites originated by degradation of carotenes through the loss of carbon atoms placed at the side chain of their structure as consequence of oxydative reactions. We present here the first review of apocarotenoids in the fungi mucorales Phycomyces blakesleeanus, Blakeslea trispora and Mucor mucedo. This review is divided into two parts: the first one presents their structures and sources, whereas the second part is dedicated to their chemical synthesis. Read More

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May 2017
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Ring Rearrangement Metathesis in 7-Oxabicyclo[2.2.1]heptene (7-Oxanorbornene) Derivatives. Some Applications in Natural Product Chemistry.

Nat Prod Commun 2017 May;12(5):713-732

Metathesis reactions is firmly established as a valuable synthetic tool in organic chemistry, clearly comparable with the venerable Diels-Alder and Wittig reactions and, more recently, with the metal-catalyzed cross-coupling reactions. Metathesis reactions can be considered as a fascinating synthetic methodology, allowing different variants regarding substrate (alkene and alkyne metathesis) and type of metathetical reactions. On the other hand, tandem metathesis reactions such. Read More

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May 2017
2 Reads

Trypanocidal Effects of Essential Oils from Selected Medicinal Plants. Synergy among the Main Components.

Nat Prod Commun 2017 May;12(5):709-712

Fourteen essential oils (EOs) from selected live germplasm of medicinal plants have been tested for their antitrypanosomal and cytotoxic activity. These plants have been domesticated and maintained under experimental cultivation. Their EOs were tested on epimastigote forms of Trypanosoma cruzi strain Y and human lung fibroblasts LC5 cell line, along with the major components of the active oils, both separately and in binary combinations. Read More

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May 2017
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Nematicidal Activity of the Essential Oil of Three Varieties of Tagetes minuta from Argentina.

Nat Prod Commun 2017 May;12(5):705-707

Essential oils composition of three Tagetes minuta varieties and a wild population (WP) from Argentina and their in vitro and in vivo nematicidal activity against root-knot nematode, Meloidogynejavanica, are described. All T. minuta EOs tested were very active against nematode juveniles (J2), but the strongest nematicidal effects were exhibited by the TmV3 variety oil, characterized by a high content of (E)-ocimenone. Read More

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May 2017
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Synthesis and Biological Evaluation of Imines Structurally Related to Resveratrol as Dual Inhibitors of VEGF Protein Secretion and hTERT Gene Expression.

Nat Prod Commun 2017 May;12(5):699-703

A group of 28 N-benzylidene aniline derivatives structurally related to the natural stilbene resveratrol has been prepared through condensation of anilines with the corresponding aldehydes. The ability of these imines to inhibit proliferation of two tumor cell lines (HT-29 and MCF-7) and one non-tumor cell line (HEK- 293) was first determined. Subsequently, we determined the ability of some of the most cytotoxic compounds to inhibit the secretion of the VEGF-A factor in HT-29 cells and to downregulate the expression of the VEGF and hTERT genes, the latter one being involved in the activation of telomerase. Read More

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May 2017
12 Reads

Cytotoxic Terphenyl Neolignans from Fungus Terana coerulea: New Natural Corticins D and E. and Revised Structure for Corticin A.

Nat Prod Commun 2017 May;12(5):695-698

The cobalt crust fungus Terana coerulea (Phanerochaetaceae family) was selected for a bio-guided study after an ethnobotanical survey at the Irati's Forest (Navarra, Spain) for its local use as antibiotic. Six extracts of increasing polarity, from hexane to hot water, were obtained from powdered dry fungi and tested for cytotoxicity against four human tumour cell lines and one non-tumour primary cell culture. From the most cytotoxic, EtOAc extract, we isolated and identified three terphenyl neolignans: two of them new natural products, named corticins D and E, and one previously described as corticin A, whose earlier structure has been revised. Read More

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The Dimerization of Precocene I.

Nat Prod Commun 2017 May;12(5):691-694

In an earlier work we reported that treatment of precocene I with Brönsted and Lewis acids produces its oligomerization, giving dimers, trimers, tetramers, etc. Now, in this article we show that bromination of precocene I with phenyltrimethylammonium tribromide (PTT) blocks its oligomerization giving a dibromo- dimer, which was reduced with tri-n-butyl tin hydride affording the same dimer obtained in the reactions with acid, thus avoiding the oligomerization. Additionally, the oxidations of precocene I with Jones reagent afforded the corresponding 3-hydroxy-4-chromanone, 3,4-chromandione, 3,4-diacid, and two dimers. Read More

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May 2017
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Profiling of Phenolic Natural Products in the Seagrass Zostera noltei by UPLC-MS.

Nat Prod Commun 2017 May;12(5):687-690

Seagrasses are marine plants that play important ecological functions in coastal ecosystems. The species Zostera noltei is widely distributed along the European coasts thriving in a variety of environmental conditions. In this study, the phenolic natural products of Z. Read More

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Optimization of the Number of Considered Conformers for the Absolute Configuration Determination of Catechin and Epicatechin Peracetates by VCD.

Nat Prod Commun 2017 May;12(5):683-686

Epimeric catechin and epicatechin peracetates offer the possibility to explore the number of conformers needed for the absolute configuration determination without affecting the reliability of the assignment. Comparisons between experimental and DFT B3PW91/DGDZVP calculated curves showed that, in molecules.where the conformational flexibility generates a large number of conformers, it is possible to significantly reduce the number of conformers needed to generate VCD results that provide secure absolute configuration assignment. Read More

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May 2017
2 Reads

New Fluvirucinins C1 and C2 Produced by a Marine Derived Actinomycete.

Nat Prod Commun 2017 May;12(5):679-682

Two new fluvirucin aglycones, named fluvirucinins C, and C2 (1-2), have been isolated from the ethyl acetate mycelial cake extract of the fermentation broth of.a marine sponge-associated actinomycete. Fluvirucinins C, (1) and C2 (2) represent a new type of 14-membered macrolactam aglycon, structurally related with the common aglycon of the known fluvirucins. Read More

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May 2017
13 Reads

Pentacyclic Triterpenoids from Maytenus cuzcoina.

Nat Prod Commun 2017 May;12(5):675-678

Phytochemical analysis of the root bark extract of Maytenus cuzcoina (Celastraceae) led to the isolation and characterization of sixteen triterpenoids with a 6/6/6/6/6 pentacyclic system, including the new 22α-hydroxy-29-methoxy-3β-tetradecanoate-olean-12-ene, and 3β,24β-epoxy-29-methoxy-2α,3α,6α- -trihydroxy-D:A-friedelane that is reported for the first time as a natural product. This is the first instance of the isolation of a tetradecanoate triterpene ester from a Celastraceae species. The structures were elucidated on the basis of spectrometric and spectroscopic methods, including ID and 2D NMR techniques. Read More

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May 2017
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Lathyrane Diterpenes from the Latex of Euphorbia laurifolia.

Nat Prod Commun 2017 May;12(5):671-673

Two new macrocyclic diterpenes, 2-epi-latazienone (4) and 15β-acetoxy-7β-nicotinoyloxy-3β,8α-di-(2-methylpropanoyloxy)-4αH,9αH,l1αH-lathyra- 5E,12E-dien-14-one (5), and three known lathyrane-type diterpenes (1-3) were isolated from Euphorbia laurifolia latex. Their structures were determined on the basis of a detailed analysis of their 1D and 2D NMR spectroscopic and mass spectral data. Read More

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May 2017
3 Reads

Highly Functionalized Ring B Labdane Synthesis as Key Intermediate in the Route to Forskolin.

Nat Prod Commun 2017 May;12(5):667-670

Sclareol has been employed as starting material for the synthesis of several advanced intermediates towards the synthesis of highly ring B oxygenated labdanes. Dinorlabdanes 6,7,8,9-tetraoxygenated with 6,7-dioxygenated functionalities with a-cis or O-cis dispositions, have been prepared and can be used for forskolin or analogues synthesis. Read More

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May 2017
1 Read

Structure-Dependent Cytotoxic Effects of Eremophilanolide Sesquiterpenes.

Nat Prod Commun 2017 May;12(5):663-665

The aim of this research was to determine the cytotoxic action of sixteen structurally-related eremophilane-type sesquiterpenes, isolated from several species of Senecio, against a panel of cancer cell lines. The cytotoxic activities were evaluated by WST-I test and the ICso values calculated. The investigated compounds exerted dose-dependent cytotoxic actions against selected cancer cell lines and no-tumoral HS5 cell line. Read More

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May 2017
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Studies in Cyclization of Aromatic Epoxy-acyclicpolyprenes: Lewis Superacids and Titanocene Chloride.

Nat Prod Commun 2017 May;12(5):657-658

Two catalytic cascade cyclization methods (radical and 'cationic) to obtain aromatic polycyclic diterpenes hydroxylated at C3 starting from aromatic epoxypolyprenes were developed. The catalytic use of the Lewis superacid bismuth triflate produces a good yield of cyclized 2 from epoxypolyprene 3. This researchmay well direct future efforts to the synthesis of bioactive natural products. Read More

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May 2017
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Antioxidant Activity of Carvone and Derivatives against Superoxide Ion.

Nat Prod Commun 2017 May;12(5):653-655

Carvone has corroborated its versatility as starting material for building blocks synthesis in organic chemistry, being achieved a new chiral lactone. It has been done a study on the antioxidant activity against superoxide of carvone and a chloro derivative that show the potent activity of the natural product (R)-carvone, 1. Read More

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May 2017
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γ-Butyrolactones from Aspergillus Species: Structures, Biosynthesis, and Biological Activities.

Nat Prod Commun 2017 May;12(5):791-800

Recently, numerous metabolites possessing uncommon structures and potent bioactivity have been isolated from strains of fungi collected from diverse environments. The genus Aspergillus is known as a rich source of y-butyrolactones. These are a group of fungal secondary metabolites, consisting of a five- membered lactone bearing two aromatic rings, which shows a great variety of biological activities. Read More

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May 2017
2 Reads

Antioxidant Activity and Chemical Composition of Essential Oils of some Aromatic and Medicinal Plants from Albania.

Nat Prod Commun 2017 May;12(5):785-790

The chemical compositions have been investigated of the volatile oils of nine populations of six species from Albania, namely Artemisia absinthium, Calamintha nepeta, Hypericum perforatum, Sideritis raeseri subsp. raeseri, Origanum vulgare subsp. hirtum from two wild . Read More

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May 2017
4 Reads

Exploiting Substrate Diversity of NRPS Led to the Generation of New Sansanmycin Analogs.

Nat Prod Commun 2017 May;12(5):781-783

Further exploration of substrate diversity of the sansaninycin biosynthetic pathway using available halogen- and methyl-phenylalanines led to the generation of diverse sansanmycin derivatives, either at the single C- or N-terminus alone or at both C- and N-termini. The structures of all of these derivatives were determined by MS/MS spectra, and amongst them, the structures of [2-Cl-Phe]-sansanmycin H (1) and [2-Cl-Phe]-sansanmycin A (2) were further identified by NMR. Both the C-terminal derivative I and the N-terminal derivative 2 were assayed for their antibacterial activitiesi and compound 1 exhibited moderate activity against P. Read More

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May 2017
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Chemical Constituents of the Root of Angelica tenuissima and their Anti-allergic Inflammatory Activity.

Nat Prod Commun 2017 May;12(5):779-780

A phthalide, levistolide A (1), and six coumarins, demethylsuberosin (2), fraxetin (3), (-)-marmesinin (4), 3'(S)-O-P-D-glucopyranosyl-3',4'-dihydroxanthyletin (5), 3'(R)-O-P-D-glucopyranosyl-3',4'-dihydroxanthyletin (6), and isopraeroside IV (7) were isolated from the methanolic extract of the roots of Angelica tenuissima Nakai. Their chemical structures were confirmed by comparing spectroscopic and reported data. All seven compounds were isolated for the first time from this plant source. Read More

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May 2017
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Canthin-6-one Isolated from Bruceajavanica Root Blocks Cancer Cells in the G2/M phase and Synergizes with Cisplatin.

Nat Prod Commun 2017 May;12(5):771-778

Poor prognosis of most cancer patients is in part, due to limited therapeutic options. Furthermore, as chemotherapy remains the standard-of-care for several cancers, partial or lack of response remains a concern and compounding this are the adverse side effects of the treatment that severely impacts the quality of life and survival. In pursuit of improving treatment options, we have opted to investigate the unique chemical skeleton of natural compounds as anticancer therapies. Read More

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May 2017
3 Reads

Study of Anti-Tuberculosis Activity Behaviour of Natural Kaurane and Trachylobane Diterpenes Compared with Structural Properties Obtained by Theoretical Calculations.

Nat Prod Commun 2017 May;12(5):763-769

A set of seven diterpenes, three kauranes and four trachylobanes, isolated from the African plant Psiadia punctulata were assayed against Mycobacterium tuberculosis and reached activity comparable with cycloserine, a second line drug used to treat tuberculosis (TB). Several structural properties of those diterpenes, such as lipophilicity, HOMO and LUMO energies, charge density, and intramolecular hydrogen bond (IHB) formation, were obtained by theoretical calculations and compared with their activities. Peculiar correlations were observed, especially between activity, lipophilicity and IHB formation. Read More

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May 2017
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Cannabidiolic Acid-Mediated Interference with AP-1 Transcriptional Activity in MDA-MB-231 Breast Cancer Cells.

Nat Prod Commun 2017 May;12(5):759-761

We reported that cannabidiolic acid (CBDA), a non-psychotropic constituent of fiber-type cannabis plants, down-regulates the mRNA expression of cyclooxygenase-2 (COX-2) in highly aggressive MDA-MB-231 human breast cancer cells. However, the molecular mechanism(s) underlying the CBDA suppression of COX-2 have not yet been elucidated in detail. In MDA-MB-231 cells, COX-2 expression is known to be tightly regulated by the transcriptional activity of activator protein-I (AP-1), which is composed of a heterodimer of c-Fos and c-Jun. Read More

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Vibrational Circular Dichroism: Recent Advances for the Assignment of the Absolute Configuration of Natural Products.

Nat Prod Commun 2017 May;12(5):641-651

Vibrational circular dichroism (VCD) emerged during the last decade as a reliable tool for the absolute configuration (AC) determination of organic compounds. The principles, instrumentation, and methodology applied prior to early 2013 were recently reviewed by us. Since VCD is a very dynamic field, the aim of this review is to update VCD advances for the AC assignment of terpenoids, aromatic compounds, alkaloids, and other natural products for the 2013-2014 period, when VCD was applied to the AC assignment of some 70 natural products. Read More

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May 2017
2 Reads

Distribution and Diversity of Usage of the Amaryllidaceae in the Traditional Remediation of Infectious Diseases.

Nat Prod Commun 2017 Apr;12(4):635-639

Globalization and multidrug resistance are amongst the factors implicated in the resurgence of infectious diseases in recent years. This has fostered a compelling need in drug discovery to replace (or supplement) existing schedules. The floral biodiversity has been identified as a viable resource platform due to its inimitable chemical characteristics as well as the presence of numerous of its members in traditional medicinal approaches towards these diseases. Read More

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April 2017
1 Read

Dietary Soy Isoflavone: A Mechanistic Insight.

Nat Prod Commun 2017 Apr;12(4):627-634

Soy, a major component of the diet for centuries contains the largest concentration of isoflavones, a class of phytoestrogens. A variety of health benefits are associated with the consumption of soy primarily because of the isoflavones genistein, daidzein, and glycitein with a potential protective effect against a number of chronic diseases. Owing to the pharmaceutical and nutraceutical properties allied with isoflavonoids and their use in functional foods, there is a growing interest in these compounds. Read More

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Coriander (Coriandrum sativum) Essential Oil: Effect on Multidrug Resistant Uropathogenic Escherichia coli.

Nat Prod Commun 2017 Apr;12(4):623-626

Coriander (Coriandruim sativum L., Apiaceae) is known for its antimicrobial activity and the aim of this study was to investigate the effect of its essential oil (CDO) against multidrug resistant uropathogenic Escherichia coli (UPEC). CDO was able to inhibit the growth of UPEC strains and propidium iodide uptake, - and electron microscopy examination suggested that bacterial structural modifications occurred. Read More

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April 2017
1 Read

Chemical Composition and Bactericidal Activity of the Essential Oils of Four Species of Annonaceae Growing in Brazilian Amazon.

Nat Prod Commun 2017 Apr;12(4):619-622

A study was conducted to determine the chemical composition and the antibacterial activity of essential oils from Bocageopsis multiflora (Mart.) R.E. Read More

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April 2017
1 Read

Elionurus tristis Essential Oil: GC-MS Analysis and Antioxidant and Antituberculosis Activities.

Nat Prod Commun 2017 Apr;12(4):615-618

Essential oil was obtained in a yield 1.1%, w/w, by steam distillation of Elionurus tristis leaves from Madagascar. The chemical composition was analyzed qualitatively and quantitatively by GC-MS and GC-FID, respectively. Read More

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April 2017
1 Read

Chemical Composition and Anti-inflammatory Activity of Algerian Thymus vulgaris Essential Oil.

Nat Prod Commun 2017 Apr;12(4):611-614

This work aims to elucidate the chemical composition of two essential oil (EO) samples obtained from the leaves of Thymus vulgaris L. (Lamiaceae) collected in two regions of Northwestern Algeria (Tlemcen and Mostaganem) and to assess their in vivo acute toxicity and anti-inflammatory activity. Sixty-six compounds could be identified by means of simultaneous GC-FID and GC-MS, accounting for 99. Read More

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April 2017
3 Reads

Chemical Investigation on Leaf, Flower and Fruit Oils of Lantana camara from Côte d'Ivoire.

Nat Prod Commun 2017 Apr;12(4):607-610

The compositions of essential oil obtained from leaves, flowers and fruits of Lantana camara L. growing in wild at Cte d'Ivoire, were investigated by GC and ¹³C NMR. Thirty-seven compounds accounting for 88. Read More

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April 2017
1 Read

Methyl 3-(5-(prop-1-yn-1-yl)thiophen-2-yl)propanoate: A Rare Acetylene Derivative from Artemisia absinthium Root Essential Oil.

Nat Prod Commun 2017 Apr;12(4):603-606

Methyl 3-(5-(prop-l-yn-l-yl)thiophen-2-yl)propanoate (1), biosynthetically and structurally related to dehydromatricaria ester, was isolated from the root essential oil of Artemisia absinthium L. (0.7% of the total oil). Read More

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April 2017
1 Read

Antiviral Activity of Aspalathus linearis against Human Influenza Virus.

Nat Prod Commun 2017 Apr;12(4):599-602

Influenza A viruses are responsible for annual epidemics and occasional pandemics, which cause significant morbidity and mortality. The limited protection offered by influenza vaccination, and the emergence of drug-resistant influenza strains, highlight the urgent need for the development of novel anti-influenza drugs. However, the search for antiviral substances from the library of low molecular weight chemical compounds is limited. Read More

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April 2017
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Improvement Effects of Wasabi (Wasabiajaponica) Leaves and Allyl Isothiocyanate on Stomach Lesions of Mongolian Gerbils Infected with Helicobacter pylori.

Nat Prod Commun 2017 Apr;12(4):595-598

The relationship between Helicobacter pylori infection and gastric cancer associated with stomach lesions has been reported. Improvement of the adverse effects induced by H. pylori is required for human health. Read More

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April 2017
1 Read

A Convergent Total Synthesis of Balticolid.

Nat Prod Commun 2017 Apr;12(4):587-594

A convergent total synthesis of the 12 membered macrolide, Balticolid (1) is described, starting from readily available homoallylic alcohol and 1,3 propane diol The synthetic strategy involves the construction of the 12-membered lactone. Read More

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April 2017
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Two New Sulfonoglycolipids from the Green Alga Codium dwarkense.

Nat Prod Commun 2017 Apr;12(4):583-585

Two new sulfonoglycosides named Codioside E (1) and Codioside F (2) have been isolated from the MeOH extract of the marine green alga Codium darkense.collected:from the coastal areas of the Gulf of Oman. The structures of these secondary metabolites were elucidated by combined analysis of lD (¹H- and ¹³C-) and 2D (H-C correlations; HSQC and HMBC) NMR spectroscopic and MS data. Read More

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April 2017
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Anti-dormant Mycobacterial Activity of Viomellein and Xanthomegnin, Naphthoquinone Dimers Produced by Marine- derived Aspergillus sp.

Nat Prod Commun 2017 Apr;12(4):579-581

In the course of a search for anti-dormant mycobacterial substances from marine-derived microorganisms, viomellein (1) and xanthomegnin (2) were re- discovered from the active fraction of the culture of a marine-derived Aspergillus sp. together with rubrosulphin (3) and asteltoxin (4) on the guidance of bioassay-guided separation. In particular, compound 1 showed higher activity against the dormant than against actively growing Mycobacterium bovis BCG and weak activity against M smegmatis. Read More

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The Antitumor Antibiotics Complex of Aureolic Acids from the Marine Sediment-associated Strain of Streptomyces sp. KNIM 9048.

Nat Prod Commun 2017 Apr;12(4):571-577

A new antibiotic complex of six aureolic acids was isolated from the marine sediment-associated strain Streptomyces sp. KMM 9048. Four of the compounds (3-6) were found to be similar but not identical to the known chromomycins A₂, A₃, demethyl chromomycin A₃ and A₄. Read More

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April 2017
3 Reads

Antibacterial Activity of 2-(3',5'-Dibromo-2'-methoxyphenoxy)-3,5- dibromophenol Isolated from Phyllospongia papyracea.

Nat Prod Commun 2017 Apr;12(4):567-569

A principal active antimicrobial compound, 2-(3',5'-dibromo-2'-methoxyphenoxy)-3,5-dibromophenol, was isolated from the methanol extract of Phyllospongiapapyracea via bioassay-guided fractionation and isolation. The crude extract and the purified compound were assayed to determine the minimal - inhibitory concentration and minimal bactericidal concentration (MBC) using the broth. microdilution method. Read More

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http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6291838PMC

Chemical Constituents of Chirita drakei.

Nat Prod Commun 2017 Apr;12(4):563-566

Chirita drakei Burtt (now accepted as Primzina drakei (B.L.Burtt) Mich. Read More

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April 2017
2 Reads

Synthesis and Bioconversion of Curcumin Analogs.

Nat Prod Commun 2017 Apr;12(4):559-562

Hydrogdnation of curcumin (1), a chemopreventive agent from Turmeric (Curcuma longa L.) yielded three major compounds: 1,7-bis(4-hydroxy-3- methoxyphenyl)heptane-3,5-dione (2), 5-hydroxy-1,7-bis(4-hydroxy-3-methoxyphenyl)heptan-3-one (3), and 1,7-bis(4-hydroxy-3-methoxyphenyl)heptane- 3,5-diol (4). Incubation of compound (2) with Beauveria bassiana ATCC 7159 afforded the hexahydrocurcumin (3) as the sole metabolite while biotransformation. Read More

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April 2017
1 Read

GC-MS-based Metabolomic Profiling of Thymoquinone in Streptozotocin-induced Diabetic Nephropathy in Rats.

Nat Prod Commun 2017 Apr;12(4):553-558

*Diabetic nephropathy is a common complication of diabetes mellitus and one of the major etiologies of end-stage renal disease. Specific therapeutic interventions are necessary to treat such complications. The present study was designed to investigate the metabolomic changes induced by thymoquinone for the treatment of diabetic nephropathy, using a rodent model. Read More

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April 2017
3 Reads

Arbutin Content and Tyrosinase Activity of Bergenia Extracts.

Nat Prod Commun 2017 Apr;12(4):549-552

The total arbutin content in the leaves of all the studied Bergenia plants (B. crassifolia, B. ciliata and B. Read More

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Variation in Phenolic Composition of Knautia arvensis in Correlation with Geographic Area and Plant Organ.

Nat Prod Commun 2017 Apr;12(4):545-548

Knautia arvensis (family Dipsacaceae) is usually found in grasslands of Europe, but can also be found in some parts of Africa and Asia, usually in dry meadows, pastures, dry hills, and open woods. The chemical composition of this species is relatively unknown. The aim of this study was to give a phenolic profile of this plant, and to show how its phenolic composition varies depending upon plant organ and geographic origin. Read More

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April 2017
1 Read

Antioxidant Activity and Phenolic Composition of a Red Bean (Phasoelus vulgaris) Extract and its Fractions.

Nat Prod Commun 2017 Apr;12(4):541-544

- The activities of the crude acetonic extract of red bean and its two fractions were determined using a 0-carotene-linoleate model system as well as the total antioxidant activity (TAA), the total phenolics content (TPC), the DPPH radical-scavenging activity, and the reducing power assays. Results from the in vitro assays showed the highest values when tannins (fraction II) were tested. Specifically, the TAA of the tannins fraction was 4. Read More

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April 2017
2 Reads

Syntheses of Benzo[c]Chromen-6-ones by Palladium Catalyzed C-H Bond Activation using Diazonium Salts.

Nat Prod Commun 2017 Apr;12(4):537-540

An efficient palladium catalyzed C-H bond activation for the synthesis of benzo[c]chromen-6-ones using diazonium salts is described. In the presence of Pd(OAc)2, dppp, PivOH and K2CO3, the diazonium salt can be transformed into the product through a denitrogenation/C-H bond activation/cyclization sequence in acetonitrile. Altogether, nine structurally diverse substituted benzoLc]chromen-6-ones were prepared in excellent yields through two different methods. Read More

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April 2017
1 Read

Main Constituents and Antidiabetic Properties of Otholobium mexicanum.

Nat Prod Commun 2017 Apr;12(4):533-535

Two phenols, bakuchiol (1) and 3-hydroxybakuchiol (2), and two isoflavone glycosides, daidzin (3) and genistin (4) were isolated from Otholobium mexicanum J. W. Grimes (Fabaceae). Read More

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April 2017
1 Read

Isoflavone Composition, Total Phenolic Content and Antioxidant Capacity of Soybeans with Colored Seed Coat.

Nat Prod Commun 2017 Apr;12(4):527-532

The influence of soybean seed coat color and genotype on antioxidant capacity, phenolic content and isoflavone profile was investigated. Isoflavone content and compositiontof 21 seed samples - yellow, green, brown, black and rarely mentioned ocher and reddish, were determined by high-performance liquid chromatographic analysis Antioxidant capacity and total phenolic content (TPC) were evaluated spectrophotometrically. Significant correlation between total isoflavone content and total genisteins was established in all colored groups. Read More

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April 2017
1 Read

Buxusoside, a Flavonoid Disaccharide from Buxus sinica.

Nat Prod Commun 2017 Apr;12(4):525-526

A new flavonoid diglycoside named buxusoside (1), together with its aglycone chrysosplenol-D (2), as well as 4', 5-dihydroxy-3,6,7-trimethoxyflavone (3) and 3',4',5-tiihydroxy-3,6,7-trimethoxyflavone (4), were isolated from the 70% EtOH extract of the air-dried plant of Buxus sinica. Its structure was elucidated mainly by iD and 2D NMR spectra. Read More

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April 2017
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