40,504 results match your criteria Natriuretic Peptides in Congestive Heart Failure


Sacubitril/valsartan in daily clinical practice: data from a prospective registry.

J Cardiovasc Pharmacol 2018 Dec 10. Epub 2018 Dec 10.

Servicio de Cardiología. Hospital Universitario Gregorio Marañón. CIBERCV. Madrid, Spain.

Sacubitril/valsartan (SV) is a new therapy in heart failure with reduced ejection fraction. Our aim was to determine the efficacy and safety of this drug daily clinical practice.We performed a multicenter registry in 10 hospitals. Read More

View Article
December 2018
1 Read

Combination of ST2 and B-type natriuretic peptide in diabetic patients with acute heart failure: relation with ventricular stiffness and outcome.

J Cardiovasc Med (Hagerstown) 2018 Dec 11. Epub 2018 Dec 11.

Cardiovascular Diseases Unit, Department of Internal Medicine, Le Scotte Hospital, University of Siena.

Background: Diabetes is a common disease in heart failure and its prevalence ranges from 10 to 30%. ST-2 is a novel biomarker of myocardial fibrosis and remodelling in heart failure and may be involved in the inflammatory process of diabetes mellitus. In this study, we sought: to evaluate levels of ST-2 and B-type natriuretic peptide (BNP) in groups with acute heart failure with and without diabetes; to analyse the prognostic impact of ST-2 over a 6-month follow-up period. Read More

View Article
December 2018

Comparison of One-Year Survival After Acute Coronary Syndrome in Patients ≥75 Years of Age With Versus Without Living With Spouse.

Am J Cardiol 2019 Jan 27;123(1):1-6. Epub 2018 Sep 27.

Department of Cardiovascular Medicine, The Second Xiangya Hospital, Central South University, Changsha, Hunan, China. Electronic address:

Patients with acute coronary syndrome (ACS) face high postevent mortality. This study aims to evaluate the impact of living without spouse on 1-year mortality of ACS patients. This retrospective study enrolled a total of 600 consecutive patients (≥75 years of age) with ACS hospitalized in our hospital between January 2013 and December 2016. Read More

View Article
January 2019

Lack of urea transporters, UT-A1 and UT-A3, increases nitric oxide accumulation to dampen medullary sodium reabsorption through ENaC.

Am J Physiol Renal Physiol 2018 Dec 12. Epub 2018 Dec 12.

Department of Physiology, Emory University School of Medicine, United States.

While the role of urea in urine concentration is known, the effect of urea handling by the urea transporters, UT-A1 and UT-A3, on sodium balance remains elusive. Serum and urinary sodium concentration is similar between wild-type mice (WT) and UT-A3 null (UT-A3 KO) mice; however, mice lacking both UT-A1 and UT-A3 (UT-A1/A3 KO) have significantly lower serum sodium and higher urinary sodium. Protein expression of renal sodium transporters is unchanged among all three genotypes. Read More

View Article
December 2018

Changes in serum and intracardiac fibroblast growth factor 23 during the progression of left ventricular hypertrophy in hypertensive model rats.

Clin Exp Nephrol 2018 Dec 11. Epub 2018 Dec 11.

Division of Nephrology and Kidney Center, Kobe University Graduate School of Medicine, 7-5-2, Kusunoki-cho, Chuo-ku, Kobe, Hyogo, 650-0017, Japan.

Background: Recent clinical studies have demonstrated that serum fibroblast growth factor 23 (FGF23) levels have a significant association with left ventricular hypertrophy (LVH). Although LVH is commonly seen in hypertensive patients, the association between FGF23, hypertension, and LVH remains unclear. We aimed to examine the changes in serum and intracardiac FGF23 during the progression of hypertension using spontaneously hypertensive rats (SHR). Read More

View Article
December 2018

Hypertension Is an Independent Predictor of Multivessel Coronary Artery Disease in Young Adults with Acute Coronary Syndrome.

Int J Hypertens 2018 13;2018:7623639. Epub 2018 Nov 13.

Department of Cardiology, The Affiliated Hospital of Qingdao University, Jiangsu Road 16, 266000 Qingdao, Shandong, China.

Background: Risk factors of multivessel coronary artery disease (CAD) among young acute coronary syndrome (ACS) patients remain elusive now.

Methods: This retrospective study analyzed data from 187 consecutive young (age ≤45 years) ACS patients (75 STEMI, 30 NSTEMI, and 72 unstable angina) hospitalized in our hospital from January 2012 to December 2016. Thirty-six young male patients with normal coronary angiography (CAG) findings (no-CAD), who underwent CAG due to suspected chest pain in this period, served as control group. Read More

View Article
November 2018

Co-exposure subacute toxicity of silica nanoparticles and lead acetate on cardiovascular system.

Int J Nanomedicine 2018 21;13:7819-7834. Epub 2018 Nov 21.

Department of Toxicology and Sanitary Chemistry, School of Public Health, Capital Medical University, Beijing 100069, PR China,

Background: The harmful effects following the release of nanomaterials into environment are of great concern today.

Purpose: In this study, subacute effect due to co-exposure to low-dose silica nanoparticles (SiNPs) and lead acetate (Pb) on cardiovascular system was detected in Sprague Dawley male rats.

Materials And Methods: Histopathological and ultrastructural changes of heart, aortic arch and abdominal aorta were detected. Read More

View Article
November 2018

Successful treatment of functional mitral regurgitation in severe heart failure with atrial pacing: A case report.

J Cardiol Cases 2014 Feb 13;9(2):50-53. Epub 2013 Dec 13.

Department of Disease Control and Homeostasis, Graduate School of Medical Science, Kanazawa University, Kanazawa, Japan.

Functional mitral regurgitation (MR) is a common complication accompanying left ventricular dysfunction. Increasing resting heart rate (HR) is demonstrated to be associated with increased mortality in heart failure (HF) patients. Thus, lowering HR is recommended by recent HF management guidelines. Read More

View Article
February 2014

A case of human immunodeficiency virus-related heart failure resembling dilated cardiomyopathy but accompanied by high cardiac output.

J Cardiol Cases 2014 Nov 26;10(5):167-170. Epub 2014 Aug 26.

Department of Cardiovascular Medicine, Graduate School of Medical Sciences, Kumamoto University, Kumamoto City, Japan.

A 34-year-old man presented with heart failure (HF). He suffered opportunistic infections and was shown to be human immunodeficiency virus (HIV)-positive (viral load: 156,013 copies/mL) and have low CD4 lymphocytes (3/mm), so he was initially treated for the opportunistic infections. Initial investigations showed high elevation of brain natriuretic peptide (BNP: 969 pg/mL). Read More

View Article
November 2014

Left ventricular plasty improved cardiac function in a case of takotsubo cardiomyopathy with persistent aneurysm.

J Cardiol Cases 2013 May 15;7(5):e133-e136. Epub 2013 Feb 15.

Department of Cardiology and Hematology, Fukushima Medical University, 1 Hikarigaoka, Fukushima 960-1295, Japan.

A 72-year-old woman was admitted to a local hospital due to repeated chest pain in December 2011. On admission, blood tests showed elevation of cardiac enzyme and B-type natriuretic peptide levels. Electrocardiography showed ST-segment elevation in almost all leads. Read More

View Article

Marked decrease in BNP levels in 2 related patients with reversible dilated cardiomyopathy.

J Cardiol Cases 2012 Feb 27;5(1):e65-e68. Epub 2011 Nov 27.

Department of Cardiovascular Medicine, Kumamoto University School of Medicine, Kumamoto, Japan.

Two male patients, one in his thirties and the other in his fifties, were admitted to different hospitals for congestive heart failure (CHF). In both patients, laboratory findings indicated high plasma B-type natriuretic peptide (BNP) levels (266.0 and 902. Read More

View Article
February 2012

Triphasic mitral inflow in acute coronary syndrome: A case study.

J Cardiol Cases 2011 Dec 18;4(3):e156-e159. Epub 2011 Sep 18.

Department of Cardiovascular Medicine, Kumamoto University School of Medicine, Kumamoto, Japan.

An 86-year-old woman was referred to our hospital for the management of rapid onset of chest pain. Blood analysis showed increased levels of cardiac enzymes and B-type natriuretic peptide. An electrocardiogram showed poor R wave in precordial leads and a QS wave in lead V4. Read More

View Article
December 2011

Renal Functions and Prognosis Stratification in Chronic Heart Failure Patients and the Importance of Neutrophil Gelatinase-Associated Lipocalin.

Kidney Blood Press Res 2018 Dec 7;43(6):1865-1877. Epub 2018 Dec 7.

Department of Internal Cardiology Medicine, Faculty Hospital Brno, Faculty of Medicine, Masaryk University, Brno, Czech Republic.

Background/aims: The rate of incidence and prevalence of acute kidney injury is increasing due to an increased number of patients with heart failure. Therefore it is very pertinent to early detect the level of renal injuries and to make necessary heart failure predictions. Thus the aim of this study is to determine renal functions and prognosis stratification in chronic heart failure patients and importance of Neutrophil Gelatinase-Associated Lipocalin (NGAL), an early diagnostic marker of acute kidney injury, as well as stratification of cardiovascular risk in heart failure patients. Read More

View Article
December 2018

The prognostic value of troponin T and N-terminal pro B-type natriuretic peptide, alone and in combination, in heart failure patients with and without diabetes.

Eur J Heart Fail 2018 Dec 10. Epub 2018 Dec 10.

BHF Cardiovascular Research Centre, University of Glasgow, Glasgow, UK.

Aims: We examined the prognostic importance of N-terminal pro B-type natriuretic peptide (NT-proBNP) and troponin T (TnT) in heart failure patients with and without diabetes.

Methods And Results: We measured NT-proBNP and TnT in the biomarker substudy of the Prospective Comparison of ARNI With ACEI to Determine Impact on Global Mortality and Morbidity in Heart Failure trial (PARADIGM-HF). Of 1907 patients, 759 (40%) had diabetes. Read More

View Article
December 2018
1 Read

Impaired pressure natriuresis and non-dipping blood pressure in Rats with early type 1 diabetes mellitus.

J Physiol 2018 Dec 7. Epub 2018 Dec 7.

The British Heart Foundation Centre for Cardiovascular Science, The Queen's Medical Research Institute, The University of Edinburgh, 47 Little France Crescent, Edinburgh, United Kingdom, EH16 4TJ.

Key Points Summary: Type 1 diabetes mellitus increases cardiovascular risk: hypertension amplifies this risk. Pressure natriuresis regulates long-term blood pressure. We induced type 1 diabetes in rats by streptozotocin injection and after three weeks demonstrated a substantial impairment of pressure natriuresis: acute increases in blood pressure did not increase renal medullary blood flow, and tubular sodium reabsorption was not downregulated. Read More

View Article
December 2018

Association of brain natriuretic peptide and adrenomedullin plasma levels with left ventricular filling pressures in end-stage renal disease patients on hemodialysis.

Eur Rev Med Pharmacol Sci 2018 Nov;22(22):7945-7951

1st Department of Cardiology, AHEPA University Hospital, Aristotle University of Thessaloniki, Thessaloniki, Greece.

Objective: Adrenomedullin (ADM) and brain natriuretic peptide (BNP) are known to be associated with elevated left ventricular filling pressures. However, little is known about this association in hemodialysis (HD) patients with preserved left ventricular ejection fraction (LVEF). Our objective was to evaluate the potential association between E/e' ratio and plasma levels of BNP and ADM in end-stage renal disease (ESRD) patients with preserved LVEF undergoing chronic hemodialysis. Read More

View Article
November 2018

MiR-98-5p regulates myocardial differentiation of mesenchymal stem cells by targeting TBX5.

Eur Rev Med Pharmacol Sci 2018 Nov;22(22):7841-7848

Intensive Care Unit, the Affiliated Yantai Yuhuangding Hospital of Qingdao University, Yantai, China.

Objective: This study aims to investigate whether miR-98-5p can participate in the myocardial differentiation of bone marrow mesenchymal stem cells (MSCs) by regulating TBX5.

Materials And Methods: In this study, we first identified the MSCs that were isolated from rat bone marrow samples. Quantitative Real Time-Polymerase Chain Reaction (qRT-PCR) was performed to detect mRNA expressions of cardiac-related genes, including brain natriuretic peptide (BNP), α-actinin, and Islet-1. Read More

View Article
November 2018

Natriuretic Peptides in Post-mortem Brain Tissue and Cerebrospinal Fluid of Non-demented Humans and Alzheimer's Disease Patients.

Front Neurosci 2018 26;12:864. Epub 2018 Nov 26.

Department of Radiology, Leiden University Medical Center, Leiden, Netherlands.

Animal studies suggest the involvement of natriuretic peptides (NP) in several brain functions that are known to be disturbed during Alzheimer's disease (AD). However, it remains unclear whether such findings extend to humans. In this study, we aimed to: (1) map the gene expression and localization of NP and their receptors (NPR) in human post-mortem brain tissue; (2) compare the relative amounts of NP and NPR between the brain tissue of AD patients and non-demented controls, and (3) compare the relative amounts of NP between the cerebrospinal fluid (CSF) of AD patients and non-demented controls. Read More

View Article
November 2018

Cardiac Manifestations in Systemic Lupus Erythematosus: A Case Report and Review of the Literature.

Am J Med Case Rep 2018 ;6(9):180-183

Department of Medicine, Division of Rheumatology, State University of New York, Downstate Medical Center/Health + Hospitals Kings County Brooklyn, NY 11203 USA.

Background: Systemic Lupus Erythematosus (SLE) is a chronic autoimmune disease with a wide range of clinical features and variable clinical course. SLE tends to affect women during childbearing years and is characterized by multi-organ involvement. Cardiac complications in SLE, which have been described to occur in about 50% of the cases, contributes to significant morbidity and mortality in this population. Read More

View Article
January 2018

B-type natriuretic peptide in patients with asymptomatic severe aortic stenosis.

Heart 2018 Dec 7. Epub 2018 Dec 7.

Department of Cardiovascular Medicine, Kyoto University Graduate School of Medicine, Kyoto, Japan.

Objectives: We sought to evaluate the prognostic impact of the B-type natriuretic peptide (BNP) levels in patients with asymptomatic severe aortic stenosis (AS), who were not referred for aortic valve replacement (AVR).

Methods: We used data from a Japanese multicentre registry, the Contemporary outcomes after sURgery and medical tREatmeNT in patients with severe Aortic Stenosis Registry, which enrolled 3815 consecutive patients with severe AS. Of those, 387 asymptomatic patients who were not referred for AVR without left ventricular dysfunction and very severe AS were subdivided into four groups based on their BNP levels (BNP<100 pg/mL, n=201; 100≤BNP<200 pg/mL, n=94; 200≤BNP<300 pg/mL, n=42 and BNP>300 pg/mL, n=50). Read More

View Article
December 2018

Diuretic, natriuretic, and vasodepressor activity of a lipid fraction enhanced in medium of cultured mouse medullary interstitial cells by a selective FAAH inhibitor.

J Pharmacol Exp Ther 2018 Dec 7. Epub 2018 Dec 7.

VCU Department of Pharmacology and Toxicology

The relationship between the endocannabinoid system in the renal medulla and the long-term regulation of blood pressure is not understood. To investigate the possible role of the endocannabinoid system in renomedullary interstitial cells, mouse medullary interstitial cells (MMICs) were obtained, cultured and characterized for their responses to treatment with a selective inhibitor of fatty acid amide hydrolase (FAAH), PF-3845. Treatment of MMICs with PF-3845 increased cytoplasmic lipid granules detected by Sudan Black B staining and multilamellar bodies identified by transmission electron microscopy. Read More

View Article
December 2018

Features of Patients Aged 80 Years or Older with Embolic Stroke of Undetermined Source.

J Stroke Cerebrovasc Dis 2018 Oct 24. Epub 2018 Oct 24.

Division of Neurology, Department of Internal Medicine, Tokai University School of Medicine, Isehara, Japan.

Background: Embolic stroke of undetermined source has not been thoroughly investigated in older patients. In this study, we investigated the features of this condition in patients greater than or equal to 80 years of age.

Methods: All patients with acute ischemic stroke in our hospital underwent diffusion-weighted imaging, magnetic resonance angiography, T2-weighted imaging, and fluid-attenuated inversion recovery sequence imaging. Read More

View Article
October 2018

Atrial natriuretic peptide attenuates endoplasmic reticulum stress in experimental acute pancreatitis.

Biochim Biophys Acta Mol Basis Dis 2018 Dec 7. Epub 2018 Dec 7.

CONICET-Universidad de Buenos Aires, Instituto de Inmunología, Genética y Metabolismo (INIGEM), Buenos Aires, Argentina; Universidad de Buenos Aires, Facultad de Farmacia y Bioquímica, Cátedra de Fisiopatología, Buenos Aires, Argentina. Electronic address:

Increasing evidence shows that the endoplasmic reticulum (ER) stress is an early event that injures pancreatic acinar cells and contributes to the pathogenesis of acute pancreatitis. In the present work we sought to establish whether atrial natriuretic peptide (ANP) alleviated ER stress in rats with cerulein-induced pancreatitis. The major components of the unfolded protein response (UPR) and their downstream effectors were assessed by immunoblotting or fluorimetry and the ultrastructure of ER evaluated by electron transmission microscopy. Read More

View Article
December 2018

Human atrial natriuretic peptide for acute kidney injury in adult critically ill patients: A multicenter prospective observational study.

J Crit Care 2018 Dec 1. Epub 2018 Dec 1.

Kyoto University Health Service, Yoshida Hon-machi, Sakyo-ku, Kyoto, Japan.

Purpose: Acute kidney injury (AKI) is common in the intensive care unit (ICU). Selected clinical studies have implied human atrial natriuretic peptide (hANP) improves renal function; however, the treatment effects for AKI are unclear.

Methods: A multicenter prospective observational study in 13 Japanese ICUs. Read More

View Article
December 2018

Characteristic expressions of the natriuretic peptide family in the telencephalon of juvenile chick.

Brain Res 2018 Dec 5. Epub 2018 Dec 5.

College of Liberal Arts and Sciences, Kitasato University, Sagamihara, Kanagawa 252-0373, Japan. Electronic address:

Elucidation of the genes regulating the critical (sensitive) period of imprinting behavior may shed light on the mechanism underlying neural plasticity in early childhood learning. We focused on the family of natriuretic peptides (NPs) as candidates involved in the regulation of the critical period. In avians, several structurally related molecules comprised the NP family, including renal NP (RNP), B-type NP (BNP) and C-type NP (CNP1, CNP3 and CNPP). Read More

View Article
December 2018

A 44-Year-Old Woman With Sudden Breathlessness, Tightness in Chest, and Hypotension After Extubation in the Early Postoperative Period After Liver Transplantation.

Chest 2018 Dec;154(6):e177-e180

Critical Care Medicine Department, Instituto Nacional de Ciencias Médicas y Nutricion Salvador Zubiran, Mexico City, Mexico. Electronic address:

Case Presentation: A 44-year-old woman with Child-Pugh class C cirrhosis due to primary biliary cirrhosis and mild portopulmonary syndrome received a liver transplant. Her basal catheterization showed a mean pulmonary arterial pressure (mPAP) of 28 mm Hg, pulmonary artery occlusion pressure (PAOP) of 8 mm Hg, pulmonary vascular resistance (PVR) of 307 dynes.s. Read More

View Article
December 2018

Induced pluripotent stem cell-derived endothelial progenitor cells attenuate ischemic acute kidney injury and cardiac dysfunction.

Stem Cell Res Ther 2018 Dec 10;9(1):344. Epub 2018 Dec 10.

Graduate Institute of Medical Genomics and Proteomics, National Taiwan University College of Medicine, Taipei, Taiwan.

Background: Renal ischemia-reperfusion (I/R) injury is a major cause of acute kidney injury (AKI), which is associated with high morbidity and mortality. AKI is a serious and costly medical condition. Effective therapy for AKI is an unmet clinical need, and molecular mechanisms underlying the interactions between an injured kidney and distant organs remain unclear. Read More

View Article
December 2018

Urine Catecholamines in Children with Severe Enterovirus A71 infection: Comparison with Paediatric Septic Shock.

Biomarkers 2018 Dec 6:1-15. Epub 2018 Dec 6.

a Children's Medical Center , Taichung Veterans General Hospital , Taichung , Taiwan.

Purpose: Hypercatecholaminemia-related heart failure has been proposed as the main cause of enterovirus A71-related (EV-A71) early mortality. The purpose of this study was to measure urine catecholamine concentrations in severe EV-A71-infected children.

Methods: A total of 35 children, aged 2. Read More

View Article
December 2018

Effects of sacubitril/valsartan on neprilysin targets and the metabolism of natriuretic peptides in chronic heart failure: a mechanistic clinical study.

Eur J Heart Fail 2018 Dec 6. Epub 2018 Dec 6.

Inserm UMR-S 942, Lariboisière Hospital, Paris, France.

Aim: This study aimed at evaluating the effects of sacubitril/valsartan on neprilysin (NEP), and the metabolism of natriuretic peptides in heart failure (HF) and providing additional mechanistic information on the mode of action of the drug.

Methods And Results: We enrolled 73 chronic HF patients who were switched from angiotensin-converting enzyme inhibitor or angiotensin receptor blocker to sacubitril/valsartan. In addition to clinical and echocardiographic assessment, plasma biomarkers were measured at baseline, day 30 and day 90 after initiation of treatment. Read More

View Article
December 2018

Preoperative Myocardial Troponin T Elevation is Associated with the Fracture Type in Patients with Proximal Femoral Fracture.

Scand J Surg 2018 Dec 6:1457496918816928. Epub 2018 Dec 6.

1 Heart Center, Turku University Hospital, Turku, Finland.

Background And Aims:: Cardiovascular complications are common in hip fracture patients but the role of fracture type and operative method in these is unclear. This prospective cohort study aimed to evaluate the impact of fracture- and operative characteristics on perioperative cardiovascular complications and prognosis in unselected hip fracture patients.

Material And Methods:: During a 7-month trial registration period, a population of 197 consecutive hip fracture patients (median age 84 years) diagnosed with femoral neck or pertrochanteric fracture was formed. Read More

View Article
December 2018

Involvement of natriuretic peptide system in C2C12 myocytes.

Mol Cell Biochem 2018 Dec 5. Epub 2018 Dec 5.

Sohyaku Innovative Research Division, Mitsubishi Tanabe Pharma Corporation, 2-2-50, Kawagishi, Toda, Saitama, 335-8505, Japan.

The natriuretic peptide system, a key regulator of cGMP signaling, comprises three types of natriuretic peptides, osteocrin/musclin (OSTN), and their natriuretic peptide receptors. Although this system plays important roles in many organs, its physiological roles in skeletal muscle have not been clearly described. In the present study, we investigated the role of the natriuretic peptide system in C2C12 myocytes. Read More

View Article
December 2018
1 Read

Natriuretic Peptide Processing in Patients with and Without Left Ventricular Dysfunction.

Int Heart J 2018 Dec 5. Epub 2018 Dec 5.

Cardiovascular Center, Onze Lieve Vrouw Ziekenhuis.

This study aimed to examine the relationship between corin expression and circulating brain natriuretic peptide in patients with left ventricular (LV) dysfunction.Circulating levels of B-type natriuretic peptide (BNP) can be an indicator of LV dysfunction. The 32-amino-acid BNP is cleaved by corin, a cardiac serine protease, from its108-amino-acid pro-brain natriuretic peptide (proBNP) precursor. Read More

View Article
December 2018

High doses of ANP and BNP exacerbate lipolysis in humans and the lipolytic effect of BNP is associated with cardiac triglyceride content in pigs.

Peptides 2018 Nov 30;112:43-47. Epub 2018 Nov 30.

Department of Clinical Biochemistry, Copenhagen University Hospital, Rigshospitalet, Copenhagen, Denmark; Department of Clinical Medicine, Aarhus University Hospital, Aarhus, Denmark; Department of Cardiorenal physiology (Mayo Clinic, Rochester, MN, USA; Copenhagen University, Denmark.

Drugs facilitating the cardioprotective effects of natriuretic peptides are introduced in heart failure treatment. ANP and BNP also stimulate lipolysis and increase circulating concentrations of free fatty acids (FFAs); an aspect, however, thought to be confined to primates. We examined the lipolytic effect of natriuretic peptide infusion in healthy young men and evaluated the effect in a porcine model of myocardial ischemia and reperfusion. Read More

View Article
November 2018

Sacubitril/valsartan (LCZ696) significantly reduces aldosterone and increases cGMP circulating levels in a canine model of RAAS activation.

Eur J Pharm Sci 2018 Nov 30;128:103-111. Epub 2018 Nov 30.

Novartis Institutes for BioMedical Research, East Hanover, NJ, USA.

Simultaneous blockade of angiotensin receptors and enhancement of natriuretic peptides (NP) by the first-in-class angiotensin receptor neprilysin (NEP) inhibitor sacubitril/valsartan constitutes an effective approach to treating heart failure. This study examined the effects of sacubitril/valsartan (225 and 675 mg/day) vs. placebo, sacubitril (360 mg/day), valsartan (900 mg/day), and benazepril (5 mg/day) on the dynamics of the renin-angiotensin-aldosterone system (RAAS) and the NP system in dogs. Read More

View Article
November 2018

Optimising standards of care of heart failure in general practice the OSCAR-HF pilot study protocol.

Acta Cardiol 2018 Dec 3:1-9. Epub 2018 Dec 3.

a Department of Public Health and Primary Care , KU Leuven (KUL) , Leuven , Belgium.

Background: Heart failure (HF) imposes a burden for patients and health economics. General practitioners (GPs) are confronted with the broadest range of HF management. Although guidelines exist, they are not fully implemented in the Belgian health care system. Read More

View Article
December 2018
1 Read

Obstructive sleep apnea in patients with chronic thromboembolic pulmonary hypertension.

J Thorac Dis 2018 Oct;10(10):5804-5812

Center for Pulmonary Vascular Diseases, Fuwai Hospital, National Center for Cardiovascular Diseases, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing 100037, China.

Background: Due to its effects, like an exaggerated negative intrathoracic pressure, sympathetic activation, systemic inflammation, oxidative stress, and endothelial dysfunction, obstructive sleep apnea (OSA) has been involved as a cause in multiple cardiovascular diseases. These diseases include coronary artery disease, hypertension, heart failure, and pulmonary hypertension (PH). Furthermore, OSA often coexists with chronic thromboembolic pulmonary hypertension (CTEPH) in clinical practice. Read More

View Article
October 2018

Exercise impedance cardiography reveals impaired hemodynamic responses to exercise in hypertensives with dyspnea.

Hypertens Res 2018 Nov 30. Epub 2018 Nov 30.

Department of Cardiology and Internal Medicine, Military Institute of Medicine, Warsaw, Poland.

Patients with arterial hypertension (AH), especially women, often report exercise intolerance and dyspnea. However, these symptoms are not frequently reflected in standard assessments. The aim of the study was to evaluate the clinical value of impedance cardiography (ICG) in the hemodynamic assessment of patients with AH during exercise, particularly the differences between subgroups based on sex and the presence of dyspnea. Read More

View Article
November 2018

Sodium tanshinone IIA sulfonate attenuates cardiac dysfunction and improves survival of rats with cecal ligation and puncture-induced sepsis.

Chin J Nat Med 2018 Nov;16(11):846-855

State Key Laboratory of Pharmaceutical Biotechnology, Medical School, Nanjing University, Nanjing 210093, China. Electronic address:

Cardiac dysfunction, a common consequence of sepsis, is the major contribution to morbidity and mortality in patients. Sodium tanshinone IIA sulfonate (STS) is a water-soluble derivative of Tanshinone IIA (TA), a main active component of Salvia miltiorrhiza Bunge, which has been widely used in China for the treatment of cardiovascular and cerebral system diseases. In the present study, the effect of STS on sepsis-induced cardiac dysfunction was investigated and its effect on survival rate of rats with sepsis was also evaluated. Read More

View Article
November 2018

Canrenone on cardiovascular mortality in congestive heart failure: Canrenone effects on cardiovascular mortality in patients with congestive heart failure: The coffee-IT study.

Pharmacol Res 2018 Nov 28. Epub 2018 Nov 28.

Medical and Surgery Sciences Department, University of Bologna, Bologna, Italy.

Aim: To evaluate canrenone effects compared to other therapies on cardiovascular mortality in patients with chronic heart failure (CHF) and preserved systolic function after 10 years of evaluation.

Methods: We enrolled 502 patients with CHF and preserved systolic function. Patients were followed with a mean follow-up of 10 years: 166 patients were in therapy with canrenone, while 336 patients were in conventional therapy. Read More

View Article
November 2018

Left atrial function in heart failure with mid-range ejection fraction differs from that of heart failure with preserved ejection fraction: a 2D speckle-tracking echocardiographic study.

Eur Heart J Cardiovasc Imaging 2018 Dec 4. Epub 2018 Dec 4.

Imperial College London (National Heart and Lung Institute), Hammersmith Hospital, Du Cane Road, London, UK.

Aims: Heart failure (HF) with mid-range ejection fraction (HFmrEF) shares similar diagnostic criteria to HF with preserved ejection fraction (HFpEF). Whether left atrial (LA) function differs between HFmrEF and HFpEF is unknown. We, therefore, used 2D-speckle-tracking echocardiography (2D-STE) to assess LA phasic function in patients with HFpEF and HFmrEF. Read More

View Article
December 2018
1 Read

Predictors of Hospitalization for Heart Failure Decompensation in 18-months Follow-up After Index Hospitalization for Acute Heart Failure.

Med Arch 2018 Oct;72(4):257-261

Clinic for Heart and Vessel Disease and Rheumatism, Clinical Center University of Sarajevo, Sarajevo, Bosnia and Herzegovina.

Introduction: Heart failure (HF) has very high rate of repeat hospitalizations due to HF decompensation (HHFD), sometimes very shortly after discharge for acute HF.

Aim: The aim of this paper is to investigate rate of HHFD and to identify their possible predictors.

Patients And Methods: Total amount of 222 patients hospitalized at Clinic for heart and vessel disease and rheumatism in acute HF were followed for next 18 months for occurrence of HHFD. Read More

View Article
October 2018

Adherence to guidelines in management of symptoms suggestive of heart failure in primary care.

Heart 2018 Dec 4. Epub 2018 Dec 4.

Department of Primary Care and Public Health, Imperial College London, London, UK.

Objective: Clinical guidelines on heart failure (HF) suggest timings for investigation and referral in primary care. We calculated the time for patients to achieve key elements in the recommended pathway to diagnosis of HF.

Methods: In this observational study, we used linked primary and secondary care data (Clinical Practice Research Datalink, a database of anonymised electronic records from UK general practices) between 2010 and 2013. Read More

View Article
December 2018
1 Read

The association among biomarkers of renal and heart function in patients with heart failure: the role of NGAL.

Biomark Med 2018 Dec 4. Epub 2018 Dec 4.

First Department of Cardiology, Hippokration Hospital, National & Kapodistrian University of Athens Medical School, Athens, Greece.

Aim: The NGAL is a biomarker of renal injury associated with the progression of heart failure (HF). We examine the association of NGAL with Galectin-3 in patients with chronic HF.

Methods: We consecutively enrolled 115 subjects with stable ischemic HF of reduced ejection fraction. Read More

View Article
December 2018

Changes in biomarkers of cardiac dysfunction during exacerbations of chronic obstructive pulmonary disease.

Respir Med 2018 Dec 14;145:192-199. Epub 2018 Nov 14.

Department of Respiratory Medicine, Waikato Hospital, Hamilton, New Zealand; Department of Preventive and Social Medicine, University of Otago, Dunedin, New Zealand.

Background: Cardiac dysfunction is associated with a higher mortality in exacerbations of chronic obstructive pulmonary disease (COPD). It is unknown how the heart responds to treatment of COPD exacerbations. We followed cardiac biomarker levels during hospital admissions for exacerbations of COPD and hypothesised that these biochemical markers of cardiac dysfunction might be affected the severity and treatment of exacerbations of COPD. Read More

View Article
December 2018
3 Reads

Carotid artery volumetric measures associate with clinical ten-year cardiovascular (CV) risk scores and individual traditional CV risk factors in rheumatoid arthritis; a carotid-MRI feasibility study.

Arthritis Res Ther 2018 Dec 3;20(1):266. Epub 2018 Dec 3.

Leeds Institute of Rheumatic and Musculoskeletal Medicine, University of Leeds, Leeds, UK.

Background: Common carotid artery intima-media thickness (CIMT), as measured by ultrasound, has utility in stratification of the accelerated cardiovascular risk seen in rheumatoid arthritis (RA); however, the technique has limitations. Carotid magnetic resonance imaging (MRI) is emerging as a useful research tool in the general population, but has yet to be applied in RA populations. Our objectives were to describe the utility of carotid artery MRI (carotid-MRI) in patients with RA in comparison to healthy controls and to describe the association with RA disease phenotype. Read More

View Article
December 2018
1 Read

Doppler myocardial performance index combined with plasma B-type natriuretic peptide levels as a marker of cardiac function in patients with decompensated cirrhosis.

Medicine (Baltimore) 2018 Nov;97(48):e13302

Department of Ultrasound, The First Affiliated Hospital of Hebei North University, Zhangjiakou.

Background: In chronic liver diseases, cirrhosis ranks as the 14th highest death cause worldwide, developing into decompensated cirrhosis. A potential and feasible technique in assessing cardiac function is urgent. This study explores if the Doppler myocardial performance (Tei) index combined with the plasma B-type natriuretic peptide (BNP) levels can assess cardiac function in patients with decompensated cirrhosis. Read More

View Article
November 2018

Plasmon Near-Field Coupling of Bimetallic Nanostars and Hierarchical Bimetallic SERS "Hot Field": Toward Ultrasensitive Simultaneous Detection of Multiple Cardiorenal Syndrome Biomarkers.

Anal Chem 2018 Nov 30. Epub 2018 Nov 30.

Cardiorenal syndrome (CRS) has posed tremendous challenges in patient management, and the detection of serum biomarkers may provide opportunities for early diagnosis and effective treatment. Herein, we introduce a novel surface-enhanced Raman scattering (SERS)-based sandwich immunoassay platform to simultaneously detect cardiac troponin I (cTnI), N-terminal prohormone of brain natriuretic peptide (NT-ProBNP) and neutrophil gelatinase-associated lipocalin (NGAL) for the early diagnosis of CRS by using Raman reporter molecules-labeled Ag-Au nanostars (Ag-Au NSs) as nanotags and three-dimensional ordered macroporous (3DOM) Au-Ag-Au plasmonic array as substrate. The Ag-Au NSs prepared by galvanic replacement feature bimetallic composition and multi-branched structure so that exhibit high SERS stability and enhancement. Read More

View Article
November 2018

Comparison of multiple biomarkers for mortality prediction in patients with acute heart failure of ischemic and nonischemic etiology.

Biomark Med 2018 Nov 30. Epub 2018 Nov 30.

Department of Cardiology, Taian City Central Hospital, Tai'an, 271000, PR China.

Aim: To investigate the prognosis of soluble ST2 (sST2), galectin-3 and N-terminal pro-B-type natriuretic peptide (NT-proBNP) for death related to ischemic and nonischemic etiology of acute heart failure (HF).

Methods: The associations between biomarkers and death were determined in 1020 patients admitted to hospital with acute HF.

Results: During 1-year follow-up, 162 patients died. Read More

View Article
November 2018
7 Reads

Circulating proteins as predictors of cardiovascular mortality in end-stage renal disease.

J Nephrol 2018 Nov 29. Epub 2018 Nov 29.

School of Health and Social Studies, Dalarna University, Falun, Sweden.

Introduction: Proteomic profiling of end-stage renal disease (ESRD) patients could lead to improved risk prediction and novel insights into cardiovascular disease mechanisms. Plasma levels of 92 cardiovascular disease-associated proteins were assessed by proximity extension assay (Proseek Multiplex CVD-1, Olink Bioscience, Uppsala, Sweden) in a discovery cohort of dialysis patients, the Mapping of Inflammatory Markers in Chronic Kidney disease cohort [MIMICK; n = 183, 55% women, mean age 63 years, 46 cardiovascular deaths during follow-up (mean 43 months)]. Significant results were replicated in the incident and prevalent hemodialysis arm of the Salford Kidney Study [SKS dialysis study, n = 186, 73% women, mean age 62 years, 45 cardiovascular deaths during follow-up (mean 12 months)], and in the CKD5-LD-RTxcohort with assessments of coronary artery calcium (CAC)-score by cardiac computed tomography (n = 89, 37% women, mean age 46 years). Read More

View Article
November 2018
2 Reads