Search Our Scientific Publications & Authors

Front Oncol 2022 30;12:793351. Epub 2022 May 30.

Department of Radiation Oncology, National Cancer Center/National Clinical Research Center for Cancer/Cancer Hospital, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing, China.

Objectives: To analyze the incidence and spread of lymph node metastasis (LNM) and the effectiveness of prophylactic neck irradiation in patients with SNSCC.

Methods: A total of 255 patients with SNSCC were retrospectively reviewed. The LNM spread pattern was revealed. Read More

Acta Oncol 2022 Jun 12:1-7. Epub 2022 Jun 12.

Department of Radiation Oncology, Wake Forest School of Medicine, Winston Salem, NC, USA.

Background: The ideal timing for the initiation of chemotherapy and radiation therapy (RT) in the use of definitive chemoradiation (CRT) for patients with head and neck cancer is not well established. We sought to evaluate the impact of the timing of initiating these two modalities on clinical outcomes.

Materials And Methods: Patients with squamous cell carcinoma of the head and neck who were treated using definitive chemoradiation from 2012 to 2018 were identified. Read More

Zhonghua Bing Li Xue Za Zhi 2022 Jun;51(6):494-499

Department of Pathology, the First Affiliated Hospital of Nanjing Medical University, Nanjing 210029, China.

To investigate the clinical, histologic, immunohistochemical (IHC) and molecular genetic features of clear cell carcinoma (CCC) of salivary gland in the head and neck regions. Seven cases of CCC diagnosed in the Department of Pathology, the First Affiliated Hospital of Nanjing Medical University from 2018 to 2021 were included. The clinical and pathologic data, HE sections and IHC staining were reviewed, and EWSR1 gene translocation was detected by fluorescence in situ hybridization (FISH). Read More

Phytomedicine 2022 Jul 21;102:154192. Epub 2022 May 21.

State Key Laboratory for Chemistry and Molecular Engineering of Medicinal Resources, Collaborative Innovation Center for Guangxi Ethnic Medicine, School of Chemistry and Pharmaceutical Sciences, Guangxi Normal University, Guilin 541004, PR China. Electronic address:

Background: Nasopharyngeal carcinoma (NPC) is a type of malignant squamous cell tumour originating from the nasopharynx epithelium. Pentagalloylglucose (PGG) is a natural polyphenolic compound that exerts anticancer effects in many types of tumours. However, the role and underlying mechanism of PGG in NPC cells have not been fully defined. Read More

Oral Oncol 2022 Jul 27;130:105932. Epub 2022 May 27.

Department of Head and Neck Medical Oncology, National Cancer Center Hospital East, Kashiwa, Chiba, Japan. Electronic address:

Objectives: In CheckMate 141, nivolumab significantly improved overall survival (OS) in patients with platinum-refractory recurrent or metastatic squamous cell carcinomas (R/M SCC) of the head and neck. However, reports on nivolumab for patients with non-SCC and/or a primary subsite excluded from CheckMate 141 are limited.

Materials And Methods: We conducted a retrospective analysis of R/M head and neck cancer patients who received nivolumab. Read More

Viruses 2022 05 13;14(5). Epub 2022 May 13.

Department of Oncology-Pathology, Karolinska Institutet, 17164 Stockholm, Sweden.

An aetiological role of human papillomavirus (HPV) and/or human polyomaviruses (HPyVs) has been proposed in adenoid cystic carcinoma (AdCC). Moreover, HPV-related multiphenotypic carcinoma (HMSC) was recently introduced as an emerging entity of the sinonasal region. Here, we primarily want to study the role of HPV/HPyV in a large AdCC cohort and, secondly, possibly identify and characterize HMSC. Read More

Cancers (Basel) 2022 May 20;14(10). Epub 2022 May 20.

Department of Otolaryngology-Head and Neck Surgery, College of Medicine, The Catholic University of Korea, Seoul 06591, Korea.

Background: Descriptive epidemiologists have repeatedly reported that males are more susceptible to head and neck cancers. However, most published data are those of cross-sectional studies, and no population-based cohort study has yet been published. The aim of this study was to compare the prevalence of head and neck cancers in healthy males with females. Read More

JAMA Otolaryngol Head Neck Surg 2022 May 26. Epub 2022 May 26.

Department of Otolaryngology and Head and Neck Surgery, School of Medicine, Stanford University, Stanford, California.

Importance: Research studies often group Native Hawaiian and Other Pacific Islander individuals together with Asian individuals despite being consistently identified as having worse health outcomes and higher rates of comorbidities and mortality. Native Hawaiian and Other Pacific Islander individuals also have high incidence rates of oral cavity and pharyngeal cancer compared with the general population; however, disparities in clinical presentation and survival outcomes of head and neck cancer squamous cell carcinoma (HNSCC) among this population have not been investigated nor compared with those of other races.

Objective: To determine the association of race with cancer stage at diagnosis and survival outcomes among Native Hawaiian and Other Pacific Islander patients with HNSCC compared with Asian and non-Hispanic White patients. Read More

Comput Math Methods Med 2022 5;2022:2056247. Epub 2022 Apr 5.

Department of Oncology, Jiujiang Hospital of Traditional Chinese Medicine, Jiujiang, 332000 Jiangxi Province, China.

Background: Nasopharyngeal carcinoma (NPC) is an invasive squamous cell carcinoma located in the nasopharynx. NPC has a high recurrence risk after initial treatment due to its high metastatic and immune escape potential. One study has found that metformin can improve cancer outcomes and reduce cancer incidence. Read More

Int Forum Allergy Rhinol 2022 Mar 21. Epub 2022 Mar 21.

Division of Otolaryngology, Department of Surgery, University of California, San Diego, San Diego, CA.

Background: Nasopharyngeal tumors (NPTs) are primarily treated with nonsurgical therapy. Recent studies have demonstrated endoscopic salvage surgery for NPT recurrences may improve survival relative to reirradiation. However, there are very limited data on open compared with endoscopic approaches for NPTs. Read More

Front Oncol 2022 24;12:781348. Epub 2022 Feb 24.

Key Laboratory of Radiation Oncology, Zhejiang Cancer Hospital, University of Chinese Academy of Sciences, Hangzhou, China.

Background: Numerous preclinical studies have revealed the complex regulatory mechanisms between anti-angiogenesis and immune inhibition in the tumor immune microenvironment and have proposed the efficacy of combined immunotherapy and anti-angiogenic treatment. Moreover, the combination strategy had been confirmed in a number of clinical trials. In this study, we aimed to evaluate the safety and efficacy of this combination strategy in recurrent/metastatic head and neck squamous cell carcinoma. Read More

Oncol Rep 2022 May 10;47(5). Epub 2022 Mar 10.

Central Research Laboratory, K.S. Hegde Medical Academy, Nitte (Deemed to be University), Mangalore, Karnataka 575018, India.

Head and neck cancers are diverse and complex diseases characterised by unregulated growth of tumour cells in various parts of the head and neck region, such as in the buccal mucosa, floor of the mouth, tongue, oropharynx, hypopharynx, oesophagus, nasopharynx and salivary glands. Partial or total glossectomy, radiation or chemotherapy greatly affect patient quality of life. However, even following treatment, patients may relapse. Read More

Sci Rep 2022 03 8;12(1):3699. Epub 2022 Mar 8.

Department of Pathology, the Second Xiangya Hospital, Central South University, Changsha, 410011, Hunan, China.

Nasopharyngeal carcinoma (NPC) is the malignant tumor arising from the nasopharynx epithelium with ethnic and geographical distribution preference. Y-box binding protein-1 (YB1) is the highly expressed DNA/RNA-binding protein with cold shock domain, and enhanced YB1 expression was proved to be associated with many kinds of malignant tumors. There is no systematic study about the regulation of YB1 and cell proliferation, migration, invasion and stress granules (SGs) in NPC, and the relationship between YB1 expression and clinical characteristics and prognosis of NPC patients. Read More

Front Oncol 2022 17;12:778643. Epub 2022 Feb 17.

Department of Radiation Oncology, Second Affiliated Hospital of Guangxi Medical University, Nanning, China.

Introduction: The optimal treatment for pulmonary and mediastinal metastasis of nasopharyngeal carcinoma (NPC) is still controversial, and the therapeutic effect is poor recently. In one case, we demonstrated a long-term survival after postoperative chemoradiotherapy combined with dendritic cell and cytokine-induced killer (DC-CIK) immunotherapy for pulmonary and mediastinal metastases from NPC.

Baseline Characteristics: A 53-year-old woman was admitted to our hospital in June 2008. Read More

Int Cancer Conf J 2022 Jan 27;11(1):75-80. Epub 2021 Nov 27.

Department of Radiation Oncology, Southern Tohoku Proton Therapy Center, 7-172, Yatsuyamada, Koriyama, Fukushima 963-8052 Japan.

Sphenoid sinus malignancies are rare diseases. Secondary hypopituitarism associated with sphenoid sinus malignancy is not well known. A 41-year-old male complained of right ptosis. Read More

J Egypt Natl Canc Inst 2022 Feb 1;34(1). Epub 2022 Feb 1.

Lung Cancer Center, West China Hospital, Sichuan University, No. 363, Section 3, Furong Avenue, Yongning Town, Wuhou District, Chengdu, China.

Background: Lymphoepithelioma-like carcinoma (LELC) is an unusual histological malignancy type. Due to the rarity of this disease, we used the Surveillance, Epidemiology, and End Results (SEER) database to investigate comprehensively and systematically the prognosis factor of LELC.

Methods: We identified 2079 patients diagnosed with LELC during 1973-2015 from the SEER database. Read More

Medicine (Baltimore) 2021 Dec;100(51):e28349

Department of Neurosurgery, Shijiazhuang Third Hospital, Shijiazhuang, China.

Rationale: Thyroid-like low-grade nasopharyngeal papillary adenocarcinoma (TL-LGNPPA) is a rare neoplasm characterized by papillary epithelial proliferation and abnormal expression of thyroid transcription factor-1. To our knowledge, squamous differentiation in TL-LGNPPA is an unusual phenomenon, and only 1 case has been reported to date. The tumor occurs mainly on the roof of the nasopharynx. Read More

Diagn Cytopathol 2022 May 21;50(5):E114-E118. Epub 2021 Dec 21.

Department of Surgery, Maulana Azad Medical College and Associated Lok Nayak Hospital, New Delhi, India.

Anal malignancies are rare, and of these squamous cell carcinoma and basaloid squamous cell carcinoma are the most common types. Anal basaloid squamous carcinoma (BSC) can show a variety of patterns including unusual variants with cribriform areas resembling adenoid cystic carcinoma (ACC). BSC is reported more frequently in elderly females. Read More

Case Rep Otolaryngol 2021 18;2021:6075130. Epub 2021 Nov 18.

Department of Surgery, Division of Otolaryngology-Head and Neck Surgery, University of Connecticut, Farmington, CT, USA.

Sinonasal malignancies are known for their associated poor prognosis and diversity of histologic features. While poor prognosis is largely due to advanced disease at presentation, histologic features also play a significant role. Therefore, accurate pathologic diagnosis is of utmost importance. Read More

Head Neck Pathol 2022 Jun 25;16(2):486-493. Epub 2021 Oct 25.

Department of Anatomic Pathology, Cleveland Clinic Foundation, 9500 Euclid ave, L25, Cleveland, OH, 44195, USA.

There is limited literature detailing the histology of pharyngeal papillomas. Herein, we report our experience with papillomas occurring in the oro-and nasopharynx that have both squamous and respiratory features akin to the sinonasal Schneiderian papilloma. We retrospectively reviewed pharyngeal papillomas that were composed of both squamous and respiratory epithelium received at our institution between 2010 and 2020. Read More

Front Immunol 2021 5;12:757047. Epub 2021 Oct 5.

Shanghai Key Laboratory of Radiation Oncology (20dz2261000), Shanghai, China.

B7 homolog 3 (B7-H3) is a recently found superfamily B7 molecule and therefore has significant involvement in immunological regulation. However, the relationships of B7-H3 expression with the tumor microenvironment (TME), response to immunotherapy, and prognosis in head and neck squamous cell carcinoma (HNSCC) are still unknown. In the present analysis, we determined B7-H3 as a novel biomarker that predicts the prognosis and response to immunotherapy in HNSCC. Read More

Cancers (Basel) 2021 Sep 30;13(19). Epub 2021 Sep 30.

Department of Radiation Oncology, City of Hope National Medical Center, Duarte, CA 91010, USA.

The complexity of head and neck cancers (HNC) mandates a multidisciplinary approach and radiation therapy (RT) plays a critical role in the optimal management of patients with HNC, either as frontline or adjuvant treatment postoperatively. The advent of both definitive and post-operative RT has significantly improved the outcomes of patients with HNC. Herein, we discuss the role of postoperative RT in different subtypes of HNC, its side effects, and the importance of surveillance. Read More

Front Oncol 2021 24;11:688615. Epub 2021 Sep 24.

Department of Radiation and Medical Oncology, Zhongnan Hospital, Wuhan University, Wuhan, China.

Objective: To investigate the impact of the human papillomavirus (HPV) status on head and neck squamous cell carcinoma (HNSCC) arising from different anatomic subsites.

Methods: HNSCC patients with known HPV status from the Surveillance, Epidemiology, and End Results (SEER) database between 2010-2015 were included in our analysis. Patients were classified into three categories of HNSCC according to Site recode ICD-O-3/WHO 2008 and Primary Site-labeled, namely, oropharynx, hypopharynx, and nasopharynx. Read More

Int J Gen Med 2021 2;14:6315-6323. Epub 2021 Oct 2.

Division of Hematology/Oncology, Georgia Cancer Center, Augusta University, Augusta, GA, 30909, USA.

Background: Squamous cell carcinoma of the nasopharynx, oropharynx and hypopharynx constitutes a majority of head neck malignancies. The incidence-based mortality across different races has been noted to be divergent. This study analyzes the trend in incidence-based mortality from the years 2000 to 2017 amongst both the genders in Caucasian/White and African American/Black patients. Read More

Korean J Gastroenterol 2021 Sep;78(3):188-194

Department of Gastrointestinal Surgery, Govind Ballabh Pant Institute of Postgraduate Medical Education and Research, New Delhi, India.

Schmincke described lymphoepithelioma as an undifferentiated carcinoma with abundant lymphoid stroma in the nasopharynx. Tumors with a similar histomorphology in extrapharyngeal areas have been referred to as lymphoepithelioma-like carcinoma (LELC). The association of an Ebstein-Barr virus (EBV) infection with lymphoepithelioma is well established in the nasopharynx but not so well at the extrapharyngeal sites. Read More

Braz J Microbiol 2021 Dec 7;52(4):1873-1880. Epub 2021 Sep 7.

Department of Microecology, School of Basic Medical Science, Dalian Medical University, No. 9, West Segment of South Lvshun Road, Lvshunkou District, Dalian, 116044, China.

Purpose: Nasopharyngeal carcinoma (NPC), an epithelial-originated malignant tumor, has a special geographic distribution. However, the etiology of NPC has not been examined in detail. Increasing pieces of evidence indicate that the microbiome may contribute to head and neck squamous cell carcinoma. Read More

Viruses 2021 08 17;13(8). Epub 2021 Aug 17.

Department of Clinical Research, Biohit Oyj, 00880 Helsinki, Finland.

Squamous cell papilloma (SCP) in the upper aero-digestive tract is a rare disease entity with bimodal age presentation both at childhood and in adults. It originates from stratified squamous and/or respiratory epithelium. Traditionally, SCPs have been linked to chemical or mechanical irritation but, since the 1980s, they have also been associated with human papillomavirus (HPV) infection. Read More

J Pharm Bioallied Sci 2021 Jun 5;13(Suppl 1):S221-S224. Epub 2021 Jun 5.

Department of Dentistry, Anugrah Narayan Magadh Medical College and Hospital, Gaya, Bihar, India.

Background: Squamous cell carcinoma is the most frequent head-and-neck malignancy and chiefly encompasses malignancies of the upper aerodigestive tract, including the oral cavity, nasal cavity, paranasal sinuses, nasopharynx, oropharynx, hypopharynx, pharynx, and larynx.

Objectives: The current study was conducted to evaluate the incidence, prevalence, and correlation of oral and esophageal cancer in the Indian population.

Materials And Methods: The present study was conducted on the basis of data collected from various government cancer hospitals in India. Read More

Ann Transl Med 2021 Jul;9(14):1148

The Cancer Hospital of the University of Chinese Academy of Sciences (Zhejiang Cancer Hospital), Institute of Basic Medicine and Cancer (IBMC), Chinese Academy of Sciences, Hangzhou, China.

Background: Ecto-5'-nucleotidase (cluster of differentiation 73/CD73) is an ectonucleotidase that is being evaluated as a biomarker for the diagnosis and prognosis of various types of cancer. However, the clinicopathological relationship between CD73 expression in monocytic MDSCs (M-MDSCs) and polymorphonuclear MDSC (PMN-MDSCs) in head and neck squamous cell carcinomas (HNSCCs) is not clear. Understanding the phenotypic and functional characteristics of human CD73 MDSCs in the tumor microenvironment could help elucidate the roles of these cells in the ontogeny, spread, and treatment of solid cancer. Read More

Toxicol Lett 2021 Oct 5;351:18-27. Epub 2021 Aug 5.

The Lenz, Hornbeam Park, Harrogate, North Yorkshire, HG2 8RE, United Kingdom.

The aim of this study was to examine whether short term, repeat dose, rat studies provide sufficient information about potential carcinogenicity to enable predictions about the carcinogenic potential of agrochemicals to be made earlier in compound development. This study aimed to identify any correlations between toxicity findings obtained for short term rat studies (28 day and 90 day) and neoplastic findings obtained from 24 month rat carcinogenicity studies for agrochemical compounds (18 compounds) tested in Han Wistar and Sprague Dawley rats. The macroscopic pathology, microscopic pathology, hematology, biochemistry, organ weights, estrogen receptor activation and genotoxicity results were examined. Read More