20,063 results match your criteria Nasopharyngeal Cancer


Treatment of Locally Advanced Nasopharyngeal Carcinoma by Helical Tomotherapy: An Observational, Prospective Analysis.

Transl Oncol 2019 Mar 14;12(5):757-763. Epub 2019 Mar 14.

Department of Radiation Oncology, The University of Texas Southwestern Medical Center, Dallas, TX.

Nasopharyngeal carcinoma (NPC) is endemic in southern China. Due to the unique anatomical and biological properties of NPCs, radiotherapy or combined modality based on radiotherapy is an effective treatment option. Helical tomotherapy (HT) is an emerging intensity modulated radiotherapy technology. Read More

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http://dx.doi.org/10.1016/j.tranon.2019.02.011DOI Listing

Mukonal Inhibits Cell Proliferation, Alters Mitochondrial Membrane Potential and Induces Apoptosis and Autophagy in Human CNE1 Nasopharyngeal Carcinoma Cells.

Med Sci Monit 2019 Mar 16;25:1976-1983. Epub 2019 Mar 16.

Department of Otolaryngology, The Second Hospital of Jilin University, Changchun, Jilin, China (mainland).

BACKGROUND Nasopharyngeal carcinoma results in high patient morbidity and mortality, due to early metastasis, and toxicity due to chemotherapy. Mukonal is plant-derived carbazole alkaloid that has been used in traditional Chinese medicine to treat several types of cancer. This study aimed to investigate the effects of mukonal on cell proliferation, apoptosis, autophagy, and the mitochondrial membrane potential of nasopharyngeal carcinoma cells in vitro. Read More

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http://dx.doi.org/10.12659/MSM.913915DOI Listing

Circulating microRNAs in head and neck cancer: a scoping review of methods.

Clin Exp Metastasis 2019 Mar 14. Epub 2019 Mar 14.

Discipline of Surgery, College of Medicine and Public Health, Flinders University, Bedford Park, Australia.

Circulating microRNAs have been described as head and neck cancer biomarkers in multiple anatomical subsites including the oral cavity, nasopharynx, larynx, salivary glands and the skin. While there is an expanding volume of published literature showing the significance of individual or panels of microRNAs, the clinical validation of candidate biomarkers is lacking. The various methods used to collect, store, process and interpret these microRNAs are likely introducing bias and contributing to the inconsistent results. Read More

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http://dx.doi.org/10.1007/s10585-019-09961-6DOI Listing
March 2019
1 Read
3.491 Impact Factor

Brain metastasis from nasopharyngeal carcinoma treated with stereotactic radiosurgery.

World Neurosurg 2019 Mar 12. Epub 2019 Mar 12.

Department of Neurosurgery, School of Medicine, Kyungpook National University, Kyungpook National University Hospital, Daegu, South Korea.

Nasopharyngeal carcinoma (NPC) is a common malignant tumor of the head and neck, and is associated with high recurrence and low survival rates; however, distant brain metastasis from NPC is rare. The authors report 3 cases of brain metastasis from NPC treated with stereotactic radiosurgery (SRS). A 49-year-old woman presented was diagnosed with brain metastasis from NPC, which occurred 53 months after initial diagnosis of NPC. Read More

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http://dx.doi.org/10.1016/j.wneu.2019.03.029DOI Listing

Radiomics on multi-modalities MR sequences can subtype patients with non-metastatic nasopharyngeal carcinoma (NPC) into distinct survival subgroups.

Eur Radiol 2019 Mar 14. Epub 2019 Mar 14.

School of Computer Science and Engineering, South China University of Technology, Guangzhou, 510006, Guangdong Province, People's Republic of China.

Objectives: To explore and evaluate the feasibility of radiomics in stratifying nasopharyngeal carcinoma (NPC) into distinct survival subgroups through multi-modalities MRI.

Methods: A total of 658 patients (training cohort: 424; validation cohort: 234) with non-metastatic NPC were enrolled in the retrospective analysis. Each slice was considered as a sample and 4863 radiomics features on the tumor region were extracted from T1-weighted, T2-weighted, and contrast-enhanced T1-weighted MRI. Read More

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http://dx.doi.org/10.1007/s00330-019-06075-1DOI Listing
March 2019
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Viral-Targeted Strategies Against EBV-Associated Lymphoproliferative Diseases.

Front Oncol 2019 26;9:81. Epub 2019 Feb 26.

Department of Paediatrics and Adolescent Medicine, Li Ka Shing Faculty of Medicine, Queen Mary Hospital, The University of Hong Kong, Hong Kong, Hong Kong.

Epstein-Barr virus (EBV) is strongly associated with a spectrum of EBV-associated lymphoproliferative diseases (EBV-LPDs) ranging from post-transplant lymphoproliferative disorder, B cell lymphomas (e.g., endemic Burkitt lymphoma, Hodgkin lymphoma, and diffuse large B cell lymphoma) to NK or T cell lymphoma (e. Read More

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http://dx.doi.org/10.3389/fonc.2019.00081DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6400835PMC
February 2019

Changes in plasma EBV-DNA and immune status in patients with nasopharyngeal carcinoma after treatment with intensity-modulated radiotherapy.

Diagn Pathol 2019 Mar 14;14(1):23. Epub 2019 Mar 14.

Department of Radiotherapy, Taizhou Central Hospital (Taizhou University Hospital), Taizhou, Zhejiang, 318000, People's Republic of China.

Background: Previous studies reported the early diagnostic values of plasma Epstein-Barr virus (EBV)-DNA. The present study aimed to assess the relationship between the concentration of plasma EBV-DNA and the number of CD8PD-1(programmed cell death-1,PD-1) and regulatory T (Treg) cells in patients with nasopharyngeal carcinoma (NPC) who were treated with intensity-modulated radiotherapy (IMRT).

Methods: This study included 37 patients treated with IMRT. Read More

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https://diagnosticpathology.biomedcentral.com/articles/10.11
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http://dx.doi.org/10.1186/s13000-019-0798-0DOI Listing
March 2019
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Systematic Review and Meta-Analysis of the Prognostic Value of Serum High-Density Lipoprotein Cholesterol Levels for Solid Tumors.

Nutr Cancer 2019 Mar 15:1-10. Epub 2019 Mar 15.

a Department of Cardiothoracic Surgery , The Third Affiliated Hospital of Soochow University , Changzhou , People's Republic of China.

Numerous studies have demonstrated that serum high-density lipoprotein cholesterol (HDL-C) levels correlate strongly with cancer patient survival. However, other studies have had the opposite results. We therefore conducted a systematic review and meta-analysis to assess the prognostic value of HDL-C levels in people with cancer. Read More

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http://dx.doi.org/10.1080/01635581.2019.1577983DOI Listing

Novel Therapeutics for Epstein⁻Barr Virus.

Molecules 2019 Mar 12;24(5). Epub 2019 Mar 12.

Laboratory of Virology and Chemotherapy, Department of Microbiology and Immunology, Rega Institute for Medical Research, KU Leuven, 3000 Leuven, Belgium.

Epstein⁻Barr virus (EBV) is a human γ-herpesvirus that infects up to 95% of the adult population. Primary EBV infection usually occurs during childhood and is generally asymptomatic, though the virus can cause infectious mononucleosis in 35⁻50% of the cases when infection occurs later in life. EBV infects mainly B-cells and epithelial cells, establishing latency in resting memory B-cells and possibly also in epithelial cells. Read More

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https://www.mdpi.com/1420-3049/24/5/997
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http://dx.doi.org/10.3390/molecules24050997DOI Listing
March 2019
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A Deep-Learning Method for Prediction of Three-Dimensional Dose Distribution of Helical Tomotherapy.

Med Phys 2019 Mar 14. Epub 2019 Mar 14.

National Cancer Center/National Clinical Research Center for Cancer/Cancer Hospital, Chinese Academy of Medical Sciences and Peking Union Medical College, 17 Panjiayuannanli, Chaoyang District, Beijing, 100021,  China.

Purpose: To develop a deep learning method for prediction of three-dimensional (3D) voxel-by-voxel dose distributions of helical tomotherapy (HT).

Methods: Using previously treated HT plans as training data, a deep learning model named U-ResNet-D was trained to predict a 3D dose distribution. First, the contoured structures and dose volumes were converted from plan database to 3D matrix with a program based on a developed visualization toolkit (VTK), then transferred to U-ResNet-D for correlating anatomical features and dose distributions at voxel-level. Read More

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http://dx.doi.org/10.1002/mp.13490DOI Listing

Dosimetric parameters associated with conductive or sensorineural hearing loss 5 years after intensity-modulated radiation therapy in nasopharyngeal carcinoma.

Acta Otolaryngol 2019 Mar 14:1-6. Epub 2019 Mar 14.

a Department of Radiation Oncology , Eye and ENT Hospital of Fudan University , Xuhui District , Shanghai , China.

Background: Most previous studies are separate dosimetric analyses of conductive or sensorineural hearing loss, and they are not conducive to a comprehensive assessment of auditory radiation damage.

Aims/objectives: Our study aimed to evaluate the long-term incidence of sensorineural hearing loss (SNHL) or conductive hearing loss (CHL) in patients with nasopharyngeal carcinoma (NPC) after intensity-modulated radiation therapy (IMRT), and to investigate the relationship between SNHL or CHL and patient factors, treatment-related factors, and radiation dose parameters.

Material And Methods: Seventy patients (117 ears) with NPC, who were also treated with IMRT in our hospital from 2006 to 2014, were retrospectively analyzed. Read More

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https://www.tandfonline.com/doi/full/10.1080/00016489.2019.1
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http://dx.doi.org/10.1080/00016489.2019.1566778DOI Listing
March 2019
1 Read

Genome-wide profiling of Epstein-Barr virus integration by targeted sequencing in Epstein-Barr virus associated malignancies.

Theranostics 2019 30;9(4):1115-1124. Epub 2019 Jan 30.

State Key Lab of Molecular Oncology, National Cancer Center/Cancer Hospital, Chinese Academy of Medical Sciences and Peking Union Medical College; Collaborative Innovation Center for Cancer Medicine, Beijing, China.

: Epstein-Barr virus (EBV) is associated with multiple malignancies with expression of viral oncogenic proteins and chronic inflammation as major mechanisms contributing to tumor development. A less well-studied mechanism is the integration of EBV into the human genome possibly at sites which may disrupt gene expression or genome stability. : We sequenced tumor DNA to profile the EBV sequences by hybridization-based enrichment. Read More

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http://dx.doi.org/10.7150/thno.29622DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6401403PMC
January 2019

Roles of β-catenin, TCF-4, and survivin in nasopharyngeal carcinoma: correlation with clinicopathological features and prognostic significance.

Cancer Cell Int 2019 28;19:48. Epub 2019 Feb 28.

1Key Laboratory for Biotechnology on Medicinal Plants of Jiangsu Province, School of Life Science, Jiangsu Normal University, No. 101, Shanghai Road, Tongshan District, Xuzhou, 221116 Jiangsu People's Republic of China.

Background: Nasopharyngeal carcinoma (NPC) is a common malignant tumor of the head and neck region with poorly understood progression and prognosis. The present study aims at exploring whether the expression of β-catenin, TCF-4, and survivin affects clinicopathological features and prognostic significance in NPC.

Methods: We enrolled 164 patients with NPC and 70 patients with chronic nasopharyngitis (CNP) in this study. Read More

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http://dx.doi.org/10.1186/s12935-019-0764-7DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6396483PMC
February 2019

Development and validation of a model for temporal lobe necrosis for nasopharyngeal carcinoma patients with intensity modulated radiation therapy.

Radiat Oncol 2019 Mar 12;14(1):42. Epub 2019 Mar 12.

Department of radiation oncology, Fudan University Shanghai Cancer Center, Shanghai, China.

Purpose: To develop and validate a quantitative complication model of temporal lobe necrosis (TLN). To analyze the effect of clinical and dosimetric factors on TLN.

Patients And Methods: In this study the prediction model was developed in a training cohort that consisted of 256 nasopharyngeal carcinoma (NPC) patients from January 2009 to December 2009. Read More

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http://dx.doi.org/10.1186/s13014-019-1250-zDOI Listing

SERPINB2 overexpression inhibited cell proliferation, invasion and migration, led to G2/M arrest, and increased radiosensitivity in nasopharyngeal carcinoma cells.

J Radiat Res 2019 Mar 13. Epub 2019 Mar 13.

Department of Radiotherapy, Qilu Hospital of Shandong University, No. 107, Wenhua West Road, Lixia District, Jinan 250012, Shandong Province, P.R. China.

The aim of this study was to evaluate the effect of SERPINB2 on cell proliferation, cell cycle, epithelial-mesenchymal transition (EMT), invasion, migration, and radiosensitivity in nasopharyngeal carcinoma cells. Both CNE2R and CNE2 cells were transfected with pEGFP-N1-SERPINB2. Cell proliferation was measured by MTT assay, cell cycle by flow cytometry, and SERpINB2 expression by quantitative real-time polymerase chain reaction (qRT-PCR). Read More

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http://dx.doi.org/10.1093/jrr/rrz003DOI Listing

Baseline hemoglobin <11.0 g/dL has stronger prognostic value than anemia status in nasopharynx cancers treated with chemoradiotherapy.

Int J Biol Markers 2019 Mar 13:1724600818821688. Epub 2019 Mar 13.

5 Koc University, School of Medicine, Department of Radiation Oncology, Istanbul, Turkey.

Background:: To retrospectively investigate the influence of pretreatment anemia and hemoglobin levels on the survival of nasopharyngeal carcinoma patients treated with concurrent chemoradiotherapy (C-CRT).

Methods:: A total of 149 nasopharyngeal carcinoma patients who received C-CRT were included. All patients had received 70 Gy to the primary tumor plus the involved lymph nodes, and 59. Read More

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http://dx.doi.org/10.1177/1724600818821688DOI Listing
March 2019
1.360 Impact Factor

Mismatch repair status and high expression of PD-L1 in nasopharyngeal carcinoma.

Cancer Manag Res 2019 19;11:1631-1640. Epub 2019 Feb 19.

Department of Radiation Oncology, Xiamen Cancer Hospital, The First Affiliated Hospital of Xiamen University, Teaching Hospital of Fujian Medical University, Xiamen, China,

Purpose: To analyze the mismatch repair (MMR) status and PD-L1 expression in nasopharyngeal carcinoma (NPC), and investigate whether PD-L1 and MMR status could be used as a biomarker for predicting response of immune checkpoint blockades (ICBs) treatment.

Patients And Methods: A total of 108 patients were initially histopathologically diagnosed with NPC between December 2017 and September 2018. All tissue specimens were collected before any treatment. Read More

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https://www.dovepress.com/mismatch-repair-status-and-high-ex
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http://dx.doi.org/10.2147/CMAR.S193878DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6388969PMC
February 2019
2 Reads

Protocadherin 17 is a tumor suppressor and is frequently methylated in nasopharyngeal carcinoma.

Cancer Manag Res 2019 18;11:1601-1613. Epub 2019 Feb 18.

Department of Otolaryngology Head and Neck Surgery, The First Affiliated Hospital of Chongqing Medical University, Chongqing, China,

Purpose: Several genes were shown to be downregulated or silenced in carcinomas and act as candidate tumor suppressor genes. However, the functions of in nasopharyngeal carcinoma (NPC) remain unclear. Here, we investigated the promoter methylation status and its impact on the expression and functions of in NPC. Read More

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http://dx.doi.org/10.2147/CMAR.S191102DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6388982PMC
February 2019

NACT+IMRT versus NACT+IMRT+CCRT in locoregionally advanced NPC patients: a retrospective study.

Onco Targets Ther 2019 22;12:1553-1562. Epub 2019 Feb 22.

Department of Radiation Oncology, Shaoxing Second Hospital, Shaoxing, Zhejiang 312000, China,

Purpose: The outcomes and safety profiles of neoadjuvant chemotherapy (NACT) + intensity modulated radiotherapy (IMRT) or NACT + IMRT + concurrent chemoradiotherapy (CCRT) in locoregionally advanced nasopharyngeal carcinoma (NPC) patients were retrospectively analyzed.

Patients And Methods: Between 2010 and 2014, 125 patients with stage III-IVb NPC, who were treated with IMRT (36, 28.8%) or IMRT + CCRT (89, 71. Read More

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February 2019

PNUTS mediates ionizing radiation-induced CNE-2 nasopharyngeal carcinoma cell migration, invasion, and epithelial-mesenchymal transition via the PI3K/AKT signaling pathway.

Onco Targets Ther 2019 15;12:1205-1214. Epub 2019 Feb 15.

Department of Otorhinolaryngology, The First Affiliated Hospital of Chongqing Medical University, Chongqing 400016, China,

Purpose: Ionizing radiation (IR) is widely used for treating nasopharyngeal carcinoma (NPC). However, recent studies indicate that IR can also promote the migration and invasion of malignant tumors. Phosphatase 1 nuclear-targeting subunit (PNUTS), a novel interacting protein, was recently demonstrated to be involved in tumorigenesis and metastasis formation. Read More

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http://dx.doi.org/10.2147/OTT.S188571DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6388972PMC
February 2019

The results of nasopharyngeal cancer patients treated by simultaneous integrated boost technique and concomitant chemotherapy

Turk J Med Sci 2019 Mar 13;49(2). Epub 2019 Mar 13.

Background/aim: To assess the efficacy and side effects of concurrent weekly chemotherapy and radiotherapy with simultaneous integrated boost (SIB) technique for nasopharyngeal cancer (NPC).

Materials And Methods: total of 51 consecutive patients with diagnosis of NPC were treated between February 2010 and December 2015. The median dose for PTV70 (range: 60–82) was given in 33 fractions (range: 31–35). Read More

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http://dx.doi.org/10.3906/sag-1605-98DOI Listing

Characteristics of symptom distress in Chinese nasopharyngeal carcinoma patients and its relation to mood disturbance: A cross-sectional study.

Eur J Cancer Care (Engl) 2019 Mar 11:e13032. Epub 2019 Mar 11.

Department of Psychology, School of Public Health, Southern Medical University, Guangzhou, Guangdong Province, China.

Objective: To evaluate the psychometric properties of a modified Chinese version of the Symptom Distress Scale (SDS), to explore symptom distress and its association with mood disturbance and factors that related to levels of symptom distress and mood disturbance.

Methods: A cross-sectional, correlation design was adopted. A convenience sample of 190 nasopharyngeal carcinoma (NPC) patients was recruited from a Cancer Center in Guangzhou, China, with 169 patients completing the study. Read More

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http://dx.doi.org/10.1111/ecc.13032DOI Listing

Clinical application of diffusion-weighted magnetic resonance imaging in radiotherapy for nasopharyngeal carcinoma.

J Xray Sci Technol 2019 Mar 2. Epub 2019 Mar 2.

Department of Radiation Oncology, The First Affiliated Hospital of Anhui Medical University, Hefei, China.

Objective: To explore the clinical application of diffusion-weighted magnetic resonance imaging (DWI) in nasopharyngeal carcinoma (NPC) diagnosis, detection of lymph node metastasis, radiotherapy and prognosis.

Methods: Twenty patients with diagnosed NPC in an early stage of radiotherapy were enrolled in our department between May 2010 and May 2013. T1 and T2 weighted magnetic resonance imaging and DWI of the nasopharynx and neck were performed 1 week before radiotherapy, during radiotherapy at a dose of 60 Gy, and 1 month after radiotherapy. Read More

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http://dx.doi.org/10.3233/XST-180441DOI Listing

Effects and mechanisms of innate immune molecules on inhibiting nasopharyngeal carcinoma.

Chin Med J (Engl) 2019 Mar;132(6):749-752

Key Laboratory of Carcinogenesis and Cancer Invasion of the Chinese Ministry of Education, Xiangya Hospital, Central South University, Changsha, Hunan 410078, China.

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http://dx.doi.org/10.1097/CM9.0000000000000132DOI Listing

The role of cross-sectional imaging in suspected nasopharyngeal carcinoma.

Ann R Coll Surg Engl 2019 Mar 11:1-3. Epub 2019 Mar 11.

Ear, Nose and Throat Department, York Teaching Hospitals NHS Foundation Trust , York , UK.

Introduction: Nasopharyngeal carcinoma is a rare neoplasm in the UK. The current gold standard for detection is endoscopic examination under anaesthesia of the nasopharynx with biopsy. Many clinicians are now advocating cross-sectional imaging as the primary investigation. Read More

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https://publishing.rcseng.ac.uk/doi/10.1308/rcsann.2019.0025
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http://dx.doi.org/10.1308/rcsann.2019.0025DOI Listing
March 2019
1 Read

O Blood Type Is Associated with Unfavorable Distant-metastasis-free Survival in Female Patients with Nasopharyngeal Carcinoma: A Retrospective Study of 2439 Patients from Epidemic Area.

J Cancer 2019 30;10(5):1297-1306. Epub 2019 Jan 30.

State Key Laboratory of Oncology in South China, Collaborative Innovation Center for Cancer Medicine, Guangdong Key Laboratory of Nasopharyngeal Carcinoma Diagnosis and Therapy, Sun Yat-sen University Cancer Center, Guangzhou 510060, P. R. China.

: To identify the association between ABO blood type and the survivals in nasopharyngeal carcinoma patients. : We retrospectively analyzed 2439 consecutive non-metastasis nasopharyngeal carcinoma patients between January 2001 and December 2004 at the Sun Yat-sen University Cancer Center. Survival outcomes were compared using Kaplan-Meier method. Read More

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http://dx.doi.org/10.7150/jca.28372DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6400674PMC
January 2019

Cloning and characterization of the putative AFAP1-AS1 promoter region.

J Cancer 2019 29;10(5):1145-1153. Epub 2019 Jan 29.

NHC Key Laboratory of Carcinogenesis, Xiangya Hospital, Central South University, Changsha, Hunan, China.

Actin filament-associated protein 1-antisense RNA1 (AFAP1-AS1), a cancer-related long non-coding RNA, has been found to be upregulated in multiple types of cancers. AFAP1-AS1 is important for the initiation, progression and poor prognosis of many cancers, including nasopharyngeal carcinoma (NPC). However, the mechanism underlying the regulation of AFAP1-AS1 expression is not well-understood. Read More

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http://www.jcancer.org/v10p1145.htm
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http://dx.doi.org/10.7150/jca.29049DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6400686PMC
January 2019
3 Reads

Corrigendum to "Long-term survival and late toxicities of elderly nasopharyngeal carcinoma (NPC) patients treated by high-total- and fractionated-dose simultaneous modulated accelerated radiotherapy with or without chemotherapy" [Oral Oncol. 89 (2019) 40-47].

Oral Oncol 2019 Mar 26;90:136. Epub 2019 Jan 26.

Department of Nasopharyngeal Carcinoma, Sun Yat-sen University Cancer Center, State Key Laboratory of Oncology in South China, Collaborative Innovation Center for Cancer Medicine, Guangdong Key Laboratory of Nasopharyngeal Carcinoma Diagnosis and Therapy, Guangzhou 510060, China. Electronic address:

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http://dx.doi.org/10.1016/j.oraloncology.2018.12.030DOI Listing

Reprint of Long-term survival and late toxicities of elderly nasopharyngeal carcinoma (NPC) patients treated by high-total- and fractionated-dose simultaneous modulated accelerated radiotherapy with or without chemotherapy.

Oral Oncol 2019 Mar 25;90:126-133. Epub 2019 Jan 25.

Department of Nasopharyngeal Carcinoma, Sun Yat-sen University Cancer Center, State Key Laboratory of Oncology in South China, Collaborative Innovation Center for Cancer Medicine, Guangdong Key Laboratory of Nasopharyngeal Carcinoma Diagnosis and Therapy, Guangzhou 510060, China. Electronic address:

Background: To analyse the survival and late toxicities of elderly nasopharyngeal carcinoma (NPC) patients treated by intensity-modulated radiotherapy (IMRT) with the high-total- and fractionated-dose simultaneous modulated accelerated radiation therapy (SMART) boost technique and to identify the effect of concurrent chemotherapy for these patients.

Methods: Two hundred and fifty-four elderly patients (age ≥ 60.0) with newly diagnosed non-metastatic NPC were retrospectively analysed. Read More

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http://dx.doi.org/10.1016/j.oraloncology.2019.01.005DOI Listing

Epstein-Barr Virus MicroRNAs in Nasopharyngeal Carcinoma.

Pathol Oncol Res 2019 Mar 9. Epub 2019 Mar 9.

Department of Pathology, Medical School, University of Athens, Athens, Greece.

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http://dx.doi.org/10.1007/s12253-019-00631-2DOI Listing

Azacoccone E inhibits cancer cell growth by targeting 3-phosphoglycerate dehydrogenase.

Bioorg Chem 2019 Feb 23;87:16-22. Epub 2019 Feb 23.

Hubei Key Laboratory of Natural Medicinal Chemistry and Resource Evaluation, School of Pharmacy, Tongji Medical College, Huazhong University of Science and Technology, Wuhan 430030, China; Wuya College of Innovation, Key Laboratory of Structure-Based Drug Design & Discovery, Ministry of Education, Shenyang Pharmaceutical University, Shenyang 110016, China. Electronic address:

Serine plays critically important roles in tumorigenesis. Homo sapiens 3-phosphoglycerate dehydrogenase (PHGDH) catalyzes the first committed step for the synthesis of glucose-derived serine via the phosphoserine pathway and has been associated with a wide variety of cancers, including breast cancer, melanoma, colon cancer, glioma, nasopharyngeal carcinoma, cervical adenocarcinoma, etc. Azacoccone E, an aza-epicoccone derivative from the culture of Aspergillus flavipes, exhibited effective inhibitory activity against PHGDH in vitro. Read More

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http://dx.doi.org/10.1016/j.bioorg.2019.02.037DOI Listing
February 2019

Long noncoding RNA DANCR promotes nasopharyngeal carcinoma progression by interacting with STAT3, enhancing IL-6/JAK1/STAT3 signaling.

Biomed Pharmacother 2019 Mar 5;113:108713. Epub 2019 Mar 5.

Department of Otorhinolaryngology, China Medical University Affiliated ShengJing Hospital, Shenyang City, Liaoning Province, China. Electronic address:

Nasopharyngeal carcinoma (NPC) is the most common type of malignancy of the neck and head in Southeast Asia and North Africa. Long noncoding RNA (LncRNA) Differentiation antagonizing nonprotein coding RNA (DANCR) has been reported to exert oncogenic functions in various malignant tumors. However, whether DANCR is involved in NPC tumorgenesis and its underlying mechanisms are still unknown. Read More

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http://dx.doi.org/10.1016/j.biopha.2019.108713DOI Listing

Long non-coding SNHG1 in cancer.

Clin Chim Acta 2019 Mar 6;494:38-47. Epub 2019 Mar 6.

Department of Radiology & Nuclear Medicine, Zhongnan Hospital of Wuhan University, Wuchang, Hubei province, Wuhan 430071, China. Electronic address:

Objectives: Long non-coding RNAs (lncRNAs) consist of a cluster of RNAs having >200 nucleotides lacking protein-coding function. Recent studies indicate that lncRNAs are involved in various cellular processes and their aberrant expression may lead to tumour development and progression. They may also serve as oncogenes or tumour suppressor genes in other diseases. Read More

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https://linkinghub.elsevier.com/retrieve/pii/S00098981193010
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http://dx.doi.org/10.1016/j.cca.2019.03.002DOI Listing
March 2019
2 Reads

Effect of CRP and Kinetics of CRP in Prognosis of Nasopharyngeal Carcinoma.

Front Oncol 2019 21;9:89. Epub 2019 Feb 21.

Department of Radiation Oncology, The First Affiliated Hospital, Sun Yat-sen University, Guangzhou, China.

Baseline C-reactive protein (CRP) has been determined as a prognostic factor in nasopharyngeal carcinoma (NPC). This study was designed to further evaluate the impact of CRP kinetics on NPC patients. Thousand three hundred and seventy eight NPC patients from February 2001 to June 2011 were retrospectively reviewed. Read More

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http://dx.doi.org/10.3389/fonc.2019.00089DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6394211PMC
February 2019

Malnutrition in head and neck cancer patients: Impacts and indications of a prophylactic percutaneous endoscopic gastrostomy.

Eur Ann Otorhinolaryngol Head Neck Dis 2019 Mar 4. Epub 2019 Mar 4.

Department of gastroenterology, School of Medicine, université Libre de Bruxelles, CHU Saint-Pierre, Brussels, Belgium.

Introduction: Head and neck cancer (HNC) patients often experience malnutrition before and during treatment. Prophylactic gastrostomy has emerged as an efficient tool for ensuring adequate nutrition. However, there is no suitable algorithm able to identify patients at high risk of malnutrition. Read More

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http://dx.doi.org/10.1016/j.anorl.2019.01.001DOI Listing

The prevalence and impact of cervical spine pathologies in patients with nasopharyngeal carcinoma.

Oral Oncol 2019 Mar 1;90:48-53. Epub 2019 Feb 1.

Department of Orthopaedics and Traumatology, The University of Hong Kong, Pok Fu Lam, Hong Kong. Electronic address:

Objectives: Nasopharyngeal carcinoma (NPC) and its treatment can lead to cervical spine pathologies such as metastases, osteoradionecrosis (ORN) and infection. However, the occurrence rate and relationship between timing of diagnosis and outcomes of the ever-advancing technology of radiation therapy is largely unknown. Hence, the aim of this study is to determine the prevalence and impact of cervical spine pathologies in patients with NPC. Read More

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http://dx.doi.org/10.1016/j.oraloncology.2019.01.013DOI Listing
March 2019
1 Read

Cervical nodal metastasis after malignant conversion of sinonasal inverted papilloma: Report of a rare case and literature review.

Oral Oncol 2019 Mar 1;90:45-47. Epub 2019 Feb 1.

Augusta University, Department of Otolaryngology-Head and Neck Surgery, Augusta, GA 30912, United States.

Malignant conversion of sinonasal inverted papilloma (SNIP) occurs in approximately ten percent of cases. These tumors are classically described as locally destructive, but without metastatic potential. Only four cases of malignant conversion with cervical nodal metastases have been described in the English literature. Read More

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http://dx.doi.org/10.1016/j.oraloncology.2019.01.024DOI Listing

Effect of prior cancer on trial eligibility and treatment outcomes in nasopharyngeal carcinoma: Implications for clinical trial accrual.

Oral Oncol 2019 Mar 1;90:23-29. Epub 2019 Feb 1.

Department of Radiation Oncology, Sun Yat-sen University Cancer Center, State Key Laboratory of Oncology in South China, Collaborative Innovation Center of Cancer Medicine, Guangdong Key Laboratory of Nasopharyngeal Carcinoma Diagnosis and Therapy, Guangzhou, Guangdong 510060, People's Republic of China. Electronic address:

Objective: In cancer trials, prior cancer is a common exclusion criterion. We evaluated the characteristics of prior cancer exclusion criteria in nasopharyngeal carcinoma (NPC) trials and determined its prognostic effect on patients with NPC.

Methods: We reviewed NPC trials for prior cancer exclusion criteria. Read More

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http://dx.doi.org/10.1016/j.oraloncology.2019.01.023DOI Listing
March 2019
1 Read

The antitumor effect of resveratrol on nasopharyngeal carcinoma cells.

Front Biosci (Landmark Ed) 2019 Mar 1;24:961-970. Epub 2019 Mar 1.

Department of Interventional Medicine, Chinese PLA Navy General Hospital, 6 Fucheng Road, Beijing, People's Republic of China.

The anti-tumor effect of resveratrol has been observed in many cancers. Here, we examined the anti-tumor activity of resveratrol in human nasopharyngeal carcinoma (NPC) cells. Resveratrol, in a dose-dependent manner, inhibited proliferation related proteins (Ki67, PCNA), and cell proliferation, and reduced apoptosis related proteins (cleaved caspase-3, cleaved caspase-9) and apoptosis in nasopharyngeal carcinoma cells. Read More

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March 2019
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Smoking can increase nasopharyngeal carcinoma risk by repeatedly reactivating Epstein-Barr Virus: An analysis of a prospective study in southern China.

Cancer Med 2019 Mar 7. Epub 2019 Mar 7.

Department of Cancer Prevention, State Key Laboratory of Oncology in Southern China, Collaborative Innovation Center for Cancer Medicine, Guangdong Key Laboratory of Nasopharyngeal Carcinoma Diagnosis and Therapy, Sun Yat-sen University Cancer Center, Guangzhou, People's Republic of China.

Background: The association between smoking and nasopharyngeal carcinoma (NPC) is still uncertain. The aim of this study was to validate smoking effect on NPC and explore if smoking can induce NPC by persistently reactivating EBV in long-term based on a prospective cohort design.

Methods: A NPC screening cohort with 10 181 eligible residents in Sihui city, southern China was conducted from 2008 to 2015. Read More

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http://dx.doi.org/10.1002/cam4.2083DOI Listing

Structure-based design of small-molecule inhibitors of EBNA1 DNA binding blocks Epstein-Barr virus latent infection and tumor growth.

Sci Transl Med 2019 Mar;11(482)

The Wistar Institute, 3601 Spruce Street, Philadelphia, PA 19104, USA.

Epstein-Barr virus (EBV) is a DNA tumor virus responsible for 1 to 2% of human cancers including subtypes of Burkitt's lymphoma, Hodgkin's lymphoma, gastric carcinoma, and nasopharyngeal carcinoma (NPC). Persistent latent infection drives EBV-associated tumorigenesis. Epstein-Barr nuclear antigen 1 (EBNA1) is the only viral protein consistently expressed in all EBV-associated tumors and is therefore an attractive target for therapeutic intervention. Read More

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http://dx.doi.org/10.1126/scitranslmed.aau5612DOI Listing
March 2019
3 Reads

Predictors of the therapeutic effect of corticosteroids on radiation-induced optic neuropathy following nasopharyngeal carcinoma.

Support Care Cancer 2019 Mar 5. Epub 2019 Mar 5.

Department of Neurology, Sun Yat-Sen Memorial Hospital, Sun Yat-Sen University, Guangzhou, China.

Radiation-induced optic neuropathy (RION) is a severe visual complication resulting from radiotherapy of the head and neck, which mostly occurs in patients with nasopharyngeal carcinoma (NPC) in the southern part of China. The mechanism of RION is unclear. Therefore, identifying risk factors for RION is an important step towards enhancing our understanding. Read More

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http://dx.doi.org/10.1007/s00520-019-04699-zDOI Listing
March 2019
1 Read

miR-144-3p facilitates nasopharyngeal carcinoma via crosstalk with PTEN.

J Cell Physiol 2019 Mar 4. Epub 2019 Mar 4.

Department of Otorhinolaryngology Head and Neck Surgery, Yantai Affiliated Hospital of Binzhou Medical University, Yantai, Shandong, China.

Aims: This study aims to investigate the role of miR-144-3p and phosphatase and tensin homolog (PTEN) in nasopharyngeal carcinoma (NPC), along with their crosstalk with the phosphoinositide 3-kinase (PI3K)-protein kinase B (Akt) pathway.

Methods: Quantitative reverse transcription polymerase chain reaction and western blot were used to measure the gene expression at the transcriptional and translational levels. 3-(4,5-Dimethylthiazol-2-yl)-2,5-diphenyltetrazolium bromide assay and colony formation assay were used to examine cell proliferation via standard protocol. Read More

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http://dx.doi.org/10.1002/jcp.28424DOI Listing

Expression of vimentin in nasopharyngeal carcinoma and its possible molecular mechanism: A study based on immunohistochemistry and bioinformatics analysis.

Pathol Res Pract 2019 Feb 27. Epub 2019 Feb 27.

Department of Pathology, First Affiliated Hospital of Guangxi Medical University, Nanning, Guangxi Zhuang Autonomous Region, 530021, China. Electronic address:

Background: Although previous researchers have analyzed the expression level of vimentin in nasopharyngeal carcinoma (NPC), the sample size of each study was too small, and there was no further in-depth study utilizing microarray and RNA-sequencing data. More importantly, the role and molecular mechanism of vimentin in NPC have not yet been addressed comprehensively. Accordingly, the aim of the present research was to conduct a full exploration of the clinical significance of vimentin in NPC in a large sample size. Read More

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http://dx.doi.org/10.1016/j.prp.2019.02.010DOI Listing
February 2019

Ultrasound Elastography supplement assessing nodal status of magnetic resonance imaging staged cervical N0 patients with nasopharyngeal carcinoma.

Cancer Imaging 2019 Mar 4;19(1):12. Epub 2019 Mar 4.

Department of Diagnostic and Interventional Ultrasound, Sun Yat-Sen University Cancer Center, State Key Laboratory of Oncology in South China, Collaborative Innovation Center for Cancer Medicine, No.651, Dong-feng-dong Road, Guangzhou, 510060, China.

Background: To determine whether ultrasound elastography can distinguish reactive or metastatic small lymph nodes (sLN) of magnetic resonance imaging (MRI) staged cervical N0 patients with nasopharyngeal carcinoma (NPC).

Methods: A pilot study was performed involving the diagnostic performances of conventional high-frequency ultrasound (CHFU) and/or shear wave elastography (SWE) for predicting metastases in sLN of MRI-staged N0 NPC patients with reference to the histologically-proven ultrasound guided core needle biopsy (US-CNB). The diagnosis of CHFU was based on the superficial lymph node ultrasonic criteria with the five-point-scale (FPS). Read More

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http://dx.doi.org/10.1186/s40644-019-0199-3DOI Listing
March 2019
1 Read

Cost-effectiveness of Screening for Nasopharyngeal Carcinoma among Asian American Men in the United States.

Otolaryngol Head Neck Surg 2019 Mar 5:194599819832593. Epub 2019 Mar 5.

1 Department of Radiation Oncology, Stanford Cancer Institute, Stanford University, Stanford, California, USA.

Objective: Most patients with nasopharyngeal carcinoma (NPC) in the United States are diagnosed with stage III-IV disease. Screening for NPC in endemic areas results in earlier detection and improved outcomes. We examined the cost-effectiveness of screening for NPC with plasma Epstein-Barr virus DNA among Asian American men in the United States. Read More

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http://dx.doi.org/10.1177/0194599819832593DOI Listing

Nasopharyngeal Carcinoma Presenting as a Diffuse Face and Neck Swelling.

Ear Nose Throat J 2019 Mar 5:145561319825715. Epub 2019 Mar 5.

1 Kaohsiung Veterans General Hospital, Kaohsiung.

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http://dx.doi.org/10.1177/0145561319825715DOI Listing

[Relationship between morphological characteristics and prognosis of non-nasopharyneal EBV-associated carcinoma].

Zhonghua Bing Li Xue Za Zhi 2019 Mar;48(3):209-214

Department of Pathology, Zhejiang Chinese Medical University Affiliated Zhejiang Cancer Hospital, Hangzhou 310022, China.

To analyze the pathological features and their influence on the clinical outcome of non-nasopharyngeal EBV-associated carcinomas. One hundred and twenty cases of non-nasopharyngeal EBV-associated carcinoma confirmed by in situ hybridization were identified at Zhejiang Cancer Hospital from January 1, 2006 to May 1, 2018, and the clinicopathological data were collected and analyzed using Kaplan-Meier survival analysis, Cox univariate and multivariate analysis. One hundred and twenty cases were involved in the study; the male to female ratio was 1∶1; patients' age range was 24 to 89 years (median 50 years). Read More

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http://dx.doi.org/10.3760/cma.j.issn.0529-5807.2019.03.008DOI Listing
March 2019
4 Reads

The identification of key genes in nasopharyngeal carcinoma by bioinformatics analysis of high-throughput data.

Mol Biol Rep 2019 Mar 4. Epub 2019 Mar 4.

The Key Laboratory of Carcinogenesis of the Chinese Ministry of Health, Xiangya Hospital, Central South University, Changsha, 410078, Hunan, China.

Nasopharyngeal carcinoma (NPC) is a common pattern of regional malignancy in the south of China, especially in Guangdong province. The development of computerized tomography (CT) technology and the improvement of radiotherapy scheme can improve the survival rate of NPC patients. However, the prevalence and recurrence rate of NPC are increasing every year. Read More

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http://dx.doi.org/10.1007/s11033-019-04729-3DOI Listing

Retinal crystalline deposits in a patient who received chemotherapy and radiotherapy for nasopharyngeal carcinoma and subsequent anti-VEGF treatment for the bilateral radiation maculopathy.

GMS Ophthalmol Cases 2019 6;9:Doc01. Epub 2019 Feb 6.

Dokuz Eylul University Medical School, Ophthalmology Department, Izmir, Turkey.

We report the occurrence of intraretinal crystalline deposits in a patient who received several anti-VEGF injections and one session of focal laser treatment for the treatment of radiation retinopathy during the treatment process. She had received three cycles of epirubicin and cisplatin together with radiation therapy seven years prior to detection of the maculopathy. The multimodal imaging features and the possible cause of the retinal crystalline deposits are discussed. Read More

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http://dx.doi.org/10.3205/oc000090DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6381419PMC
February 2019