24,546 results match your criteria Nasopharyngeal Cancer


Apigenin in Cancer Prevention and Therapy: A Systematic Review and Meta-Analysis of Animal Models.

Crit Rev Oncol Hematol 2022 Jun 22:103751. Epub 2022 Jun 22.

Molecular Cancer Genetics & Translational Research Lab, Section of Genetics, Department of Zoology, Aligarh Muslim University, Aligarh-202002, India. Electronic address:

Background: Apigenin is being increasingly recognized as a cancer chemopreventive agent. We aimed to investigate the anticancer effects of Apigenin in in-vivo studies to know its present research status and how close or how far it is from the clinics.

Methods: Several electronic databases such as PubMed, Springer, Cochrane, and ctri. Read More

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Endoscopic surgery is superior to intensity modulated radiotherapy in the treatment of advanced recurrent nasopharyngeal carcinoma.

Int Forum Allergy Rhinol 2022 Jun 24. Epub 2022 Jun 24.

ENT institute and Department of Otorhinolaryngology, Eye & ENT Hospital, Fudan University, Shanghai, 200031, China.

Background: The choice between endoscopic surgery and re-radiotherapy as the main treatment modality in patients with advanced recurrent nasopharyngeal carcinoma (rNPC) remains controversial. Therefore, in this study, we compared the efficacies of endoscopic surgery and intensity-modulated radiotherapy (IMRT) in patients with rNPC.

Methods: All patients with advanced rNPC (T3 and T4) who underwent salvage treatment were enrolled from January 2009 to December 2020. Read More

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Use of circulating tumour DNA in nasopharyngeal carcinoma to detect minimal residual disease.

BMJ Case Rep 2022 Jun 24;15(6). Epub 2022 Jun 24.

Hematology and Medical Oncology, Oakland University William Beaumont School of Medicine, Troy, Michigan, USA.

Circulating tumour DNA (ctDNA) is defined as short DNA sequences shed by tumour cells into the systemic circulation. A promising use of ctDNA includes the detection of minimal residual disease (MRD) and is currently being studied in multiple types of solid tumours. Literature for the use of individualised ctDNA in nasopharyngeal carcinoma (NPC) is not available, although circulating Epstein-Barr virus DNA level is validated as a prognostic factor. Read More

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Deep Learning-Fuzzy Inference (DeLFI): an interpretable model for detecting indirect immunofluorescence patterns associated with nasopharyngeal cancer.

Am J Pathol 2022 Jun 21. Epub 2022 Jun 21.

Temasek Life Sciences Laboratory, Singapore; Pathnova Laboratories Pte. Ltd., 1 Research Link, #05-40, Singapore 117604; Department of Biological Sciences, National University of Singapore, Singapore. Electronic address:

The detection of serum antibodies to Epstein-Barr Virus proteins by immunofluorescence assay (IFA) is considered the gold standard for nasopharyngeal cancer (NPC) screening in high-risk populations. Given the high survival rates of early asymptomatic patients compared to the poor prognosis for late-stage NPC, IFA has tremendous life-saving potential for general population screening. However, IFA requires visual interpretation of cellular staining patterns by trained pathology staff, making it labor-intensive and hence unscalable. Read More

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Treatment Strategy of Metastatic Nasopharyngeal Carcinoma With Bone Marrow Involvement-A Case Report.

Front Oncol 2022 7;12:877451. Epub 2022 Jun 7.

Department of Radiation Oncology, The Second Affiliated Hospital of Zhejiang University, School of Medicine, Hangzhou, China.

Bone marrow involvement (BMI) of solid tumors is a special type of distant metastasis. It has an occult onset, atypical clinical and laboratory features, and a high mortality. We present a nasopharyngeal carcinoma case with cervical and axillary lymph nodes, bilateral lung, multiple bone, and bone marrow metastases, who was treated chemotherapy plus targeted therapy under the guidance of a patient-derived tumor xenograft (PDTX) model, followed by maintenance chemotherapy plus immunotherapy. Read More

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Direct NP- A cost-effective extraction-free RT-qPCR based test for SARS-CoV-2.

Heliyon 2022 Jun 15;8(6):e09735. Epub 2022 Jun 15.

Department of Biochemistry and Molecular Biology, Hollings Cancer Center, Medical University of South Carolina, Charleston, SC 29425, USA.

Over 2.4 million daily total tests are currently being performed for SARS-CoV-2, in the United States. The most common SARS-CoV-2 tests require RNA extraction and purification. Read More

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MADE: A Computational Tool for Predicting Vaccine Effectiveness for the Influenza A(H3N2) Virus Adapted to Embryonated Eggs.

Vaccines (Basel) 2022 Jun 6;10(6). Epub 2022 Jun 6.

Human Genomics, Genome Institute of Singapore, Agency for Science, Technology and Research, Singapore 138672, Singapore.

Seasonal Influenza H3N2 virus poses a great threat to public health, but its vaccine efficacy remains suboptimal. One critical step in influenza vaccine production is the viral passage in embryonated eggs. Recently, the strength of egg passage adaptation was found to be rapidly increasing with time driven by convergent evolution at a set of functionally important codons in the hemagglutinin (HA1). Read More

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Lower-Neck Sparing Using Proton Therapy in Patients with Uninvolved Neck Nasopharyngeal Carcinoma: Is It Safe?

J Clin Med 2022 Jun 9;11(12). Epub 2022 Jun 9.

Radiation Oncology, Clinical Department, National Center for Oncological Hadrontherapy (CNAO), Strada Campeggi 53, 27100 Pavia, Italy.

Undifferentiated carcinoma of the nasopharynx (NPC) is a rare disease, which usually occurs in the Asian population. Due to its anatomic location, it is characterised by rich lymph node drainage and has a high incidence of cervical node metastasis. However, cervical nodal metastasis commonly involves retropharyngeal nodes and level II nodes, followed by level III nodes. Read More

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Epstein-Barr Virus Association with Breast Cancer: Evidence and Perspectives.

Biology (Basel) 2022 May 24;11(6). Epub 2022 May 24.

Universidad de Tarapacá, Arica 1000000, Chile.

Epstein-Barr virus (EBV) is an enveloped DNA virus that belongs to the gamma Herpesviridae family. The virus establishes a latent/lytic persistent infection, though it can be involved in cancer development in some subjects. Indeed, evidence supports an etiological role of EBV in undifferentiated nasopharyngeal carcinoma (NPC), a subset of gastric carcinomas and lymphomas. Read More

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19th International Symposium on Epstein-Barr Virus and Associated Diseases, 29-30 July 2021, Asahikawa, Japan.

Cancers (Basel) 2022 Jun 14;14(12). Epub 2022 Jun 14.

Department of Otolaryngology-Head and Neck Surgery, Asahikawa Medical University, Asahikawa 078-8510, Japan.

Novel insights into Epstein-Barr virus (EBV) pathogenicity were presented at the "19th International Symposium on Epstein-Barr Virus and Associated Diseases" in Asahikawa, Japan. In addition, basic and translational findings on EBV-associated tumors, including natural killer (NK)/T-cell lymphoma, gastric cancer, and nasopharyngeal cancer, were presented by an international group of scientists and clinicians. Read More

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Liquid Biopsy in Head and Neck Cancer: Current Evidence and Future Perspective on Squamous Cell, Salivary Gland, Paranasal Sinus and Nasopharyngeal Cancers.

Cancers (Basel) 2022 Jun 9;14(12). Epub 2022 Jun 9.

Medical Oncology Department, Hospital Clínico Universitario San Carlos, Instituto de Investigación Sanitaria San Carlos (IdISSC), 28040 Madrid, Spain.

Head and neck cancer (HNC) is currently the sixth most common solid malignancy, accounting for a 50% five-year mortality rate. In the past decade, substantial improvements in understanding its molecular biology have allowed for a growing development of new biomarkers. Among these, the field of liquid biopsy has seen a sustained growth in HNC, demonstrating the feasibility to detect different liquid biomarkers such as circulating tumor DNA (ctDNA), circulating tumor cells (CTC), extracellular vesicles and microRNAs. Read More

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Protein Farnesylation on Nasopharyngeal Carcinoma, Molecular Background and Its Potential as a Therapeutic Target.

Cancers (Basel) 2022 Jun 8;14(12). Epub 2022 Jun 8.

Department of Otolaryngology-Head and Neck Surgery, Kanazawa University, 13-1 Takaramachi, Kanazawa 920-8640, Japan.

Nasopharyngeal carcinoma (NPC) is one of the Epstein-Barr virus (EBV)-associated malignancies. NPC is highly metastatic compared to other head and neck carcinomas, and evidence has shown that the metastatic features of NPC are involved in EBV infection. The prognosis of advanced cases, especially those with distant metastasis, is still poor despite advancements in molecular research and its application to clinical settings. Read More

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Prior cancer history predicts the worse survival of patients with nasopharyngeal carcinoma.

Eur Arch Otorhinolaryngol 2022 Jun 22. Epub 2022 Jun 22.

Department of Otorhinolaryngology-Head and Neck Surgery, Taipei Veterans General Hospital, No. 201, Sec. 2, Shipai Rd., Taipei, 11217, Taiwan.

Purpose: Previous cancers can be observed in patients with nasopharyngeal carcinoma (NPC). However, whether prior cancer diagnosis affects survival outcomes remains unknown. This study aimed to explore the impact of prior cancer on the survival of patients with NPC. Read More

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Prognostic value of PD-L1 and Siglec-15 expression in patients with nasopharyngeal carcinoma.

Sci Rep 2022 Jun 21;12(1):10401. Epub 2022 Jun 21.

Department of Oncology, The Affiliated Hospital of Southwest Medical University, Luzhou, 646000, China.

Sialic acid-binding immunoglobulin-like lectin 15 (Siglec-15) might be involved in the activation of important pathways related to tumor immune escape, along with programmed death-ligand 1 (PD-L1). Here, we aimed to investigate the correlation between the expression of Siglec-15 and PD-L1 in nasopharyngeal carcinoma (NPC) patients. We determined the expression of PD-L1 via immunohistochemical staining and that of Siglec-15 via immunofluorescence staining in 182 NPC tissue samples. Read More

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Epidemiology of community-acquired pneumonia among hospitalised children in Indonesia: a multicentre, prospective study.

BMJ Open 2022 Jun 21;12(6):e057957. Epub 2022 Jun 21.

National Institute of Allergy and Infectious Diseases, Bethesda, Maryland, USA.

Objective: To identify aetiologies of childhood community-acquired pneumonia (CAP) based on a comprehensive diagnostic approach.

Design: 'Partnerships for Enhanced Engagement in Research-Pneumonia in Paediatrics (PEER-PePPeS)' study was an observational prospective cohort study conducted from July 2017 to September 2019.

Setting: Government referral teaching hospitals and satellite sites in three cities in Indonesia: Semarang, Yogyakarta and Tangerang. Read More

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User acceptability of saliva and gargle samples for identifying COVID-19 positive high-risk workers and household contacts.

Diagn Microbiol Infect Dis 2022 May 26;104(1):115732. Epub 2022 May 26.

MRC Human Genetics Unit, Institute of Genetics and Cancer, University of Edinburgh, UK. Electronic address:

Throughout the COVID-19 pandemic nasopharyngeal or nose and/or throat swabs (NTS) have been the primary approach for collecting patient samples for the subsequent detection of viral RNA. However, this procedure, if undertaken correctly, can be unpleasant and therefore deters individuals from providing high quality samples. To overcome these limitations other modes of sample collection have been explored. Read More

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Plasma Epstein-Barr viral DNA load after completion of two cycles of induction chemotherapy predicts outcomes for patients with advanced-stage nasopharyngeal carcinoma.

Oral Oncol 2022 Jun 18;131:105972. Epub 2022 Jun 18.

Department of Radiation Oncology, Fujian Medical University Cancer Hospital, Fujian Cancer Hospital, Fuzhou, Fujian, China; Fujian Key Laboratory of Translational Cancer Medicine, Fuzhou, Fujian, China. Electronic address:

Objectives: To evaluate the prognostic value of plasma Epstein-Barr virus DNA level following the completion of two induction chemotherapy cycles (ICT; post-DNA) in locoregionally advanced nasopharyngeal carcinoma (LA-NPC).

Materials And Methods: This retrospective study included 534 patients with LA-NPC. Recursive partitioning analysis (RPA) was applied to derive a prognostic model for risk stratification. Read More

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Phase I study of adjuvant immunotherapy with autologous tumor-infiltrating lymphocytes in locally advanced cervical cancer.

J Clin Invest 2022 Jun 21. Epub 2022 Jun 21.

Department of Biotherapy, Sun Yat-sen University Cancer Center, Guangzhou, China.

Background: Adoptive cell therapy (ACT) with tumor-infiltrating lymphocytes (TILs) has achieved remarkable clinical efficacy in metastatic cancers such as melanoma and cervical cancer (CC). Here we explored the safety, feasibility and preliminary tumor response and performed translational investigations of adjuvant immunotherapy using infusion of autogenous (auto)-TILs following concurrent chemoradiotherapy (CCRT) in CC patients with locally advanced disease.

Methods: Twenty-seven CC patients with stage III to IV disease were recruited in this single-center, phase I study. Read More

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[Expression of pepsin in nasopharyngeal carcinoma and its correlation with quality of life after radiotherapy].

Zhonghua Er Bi Yan Hou Tou Jing Wai Ke Za Zhi 2022 Jun;57(6):699-705

Department of Otorhinolaryngology, Affiliated Hospital of Guizhou Medical University, Guiyang 550004, china.

By analyzing the expression of pepsin in nasopharyngeal carcinoma (NPC) tissues, to investigate the correlation between laryngeal reflux (LPR) and NPC, as well as the effect of LPR on the quality of life of patients with NPC after radiotherapy. A total of 133 patients with NPC who underwent radiotherapy at the Department of Otorhinolaryngology of the Affiliated Hospital of Guizhou Medical University and the Affiliated Cancer Hospital of Guizhou Medical University from 2005 to 2019 were enrolled consecutively, including 90 males and 43 females, aged (44.32±7. Read More

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Induction chemotherapy in nasopharyngeal carcinoma- A systematic review of phase III clinical trials.

Cancer Treat Res Commun 2022 Jun 12;32:100589. Epub 2022 Jun 12.

Department of Radiation Oncology, Regional Cancer Centre, Thiruvananthapuram, Kerala, India. Electronic address:

Background: Induction Chemotherapy (IC) has the potential advantage of resulting in early eradication of micro metastasis thereby reducing distant failure in Nasopharyngeal Carcinoma (NPC). This study is to evaluate the effectiveness of induction chemotherapy in NPC based on published phase III Randomized Controlled Trials (RCT) METHODS: : We searched PubMed, SCOPUS, EMBASE and COCHRANE databases for phase III trials evaluating the role of IC in NPC using the following key words: nasopharyngeal carcinoma, locally advanced, locoregionally advanced, induction chemotherapy, and concurrent chemoradiation. We included phase 3 RCTs of NPC in which intervention patients received induction chemotherapy plus concurrent chemoradiation (CCRT) and the control patients received CCRT alone. Read More

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FOXP4-AS1 May be a Potential Prognostic Biomarker in Human Cancers: A Meta-Analysis and Bioinformatics Analysis.

Front Oncol 2022 26;12:799265. Epub 2022 May 26.

The First Clinical Medical College of Gansu University of Chinese Medicine (Gansu Provincial Hospital), Lanzhou, China.

Background: Cancer is one of the leading causes of death worldwide. Early diagnosis can significantly lower cancer-related mortality. Studies have shown that the lncRNA Forkhead box P4 antisense RNA 1 (FOXP4-AS1) is aberrantly expressed in various solid tumors. Read More

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miR-150-5p inhibits nasopharyngeal cancer genesis by suppressing PYCR1.

Am J Med Sci 2022 Jun 16. Epub 2022 Jun 16.

Department of Otolaryngology Head and Neck Surgery, The First Affiliated Hospital of Hainan Medical University, Haikou, 570102, Hainan, China. Electronic address:

Background: Nasopharyngeal cancer (NPC) is a rare cancer type with a low five-year survival rate. Dysregulation of PYCR1 and miR-150-5p has been involved in the development of various cancers. However, the molecular mechanism of the miR-150-5p-PYCR1 axis in NPC remains unclear. Read More

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Longitudinal study of irradiation-induced brain functional network alterations in patients with nasopharyngeal carcinoma.

Radiother Oncol 2022 Jun 16. Epub 2022 Jun 16.

Department of Medical Imaging, Sun Yat-sen University Cancer Center, State Key Laboratory of Oncology in South China, Collaborative Innovation Center for Cancer Medicine, Guangdong Key Laboratory of Nasopharyngeal Carcinoma Diagnosis and Therapy, Guangzhou, China. Electronic address:

Background: To investigate radiotherapy (RT)-related brain network changes in patients with nasopharyngeal carcinoma (NPC) over time and develop least absolute shrinkage and selection operator (LASSO)-based multivariable normal tissue complication probability (NTCP) models to predict RT-related brain network changes.

Methods: 36 NPC patients were followed up at four timepoints: baseline, within 3 months (acute), 6 months (subacute), and 12 months (delayed) post-RT. 15 comparable healthy controls (HCs) were finally included and followed up in parallel. Read More

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SARS-CoV-2 infection in cancer patients on active therapy after the booster dose of mRNA vaccines.

Eur J Cancer 2022 May 25;171:143-149. Epub 2022 May 25.

Center for Immuno-Oncology, Medical Oncology and Immunotherapy, Department of Oncology, University Hospital of Siena, Siena, Italy; University of Siena, Siena, Italy; Italian Network for Tumor Bio-Immunotherapy Foundation Onlus, Italy. Electronic address:

Introduction: The protective role against SARS-CoV-2 infection by the third booster dose of mRNA vaccines in cancer patients with solid malignancies is presently unknown. We prospectively investigated the occurrence of COVID-19 in cancer patients on active therapy after the booster vaccine dose.

Methods: Cancer patients on treatment at the Center for Immuno-Oncology (CIO) of the University Hospital of Siena, Italy, and health care workers at CIO who had received a booster third dose of mRNA vaccine entered a systematic follow-up monitoring period to prospectively assess their potential risk of SARS-CoV-2 infection. Read More

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Tumor cell-derived exosome RNF126 affects the immune microenvironment and promotes nasopharyngeal carcinoma progression by regulating PTEN ubiquitination.

Apoptosis 2022 Jun 19. Epub 2022 Jun 19.

Department of Otolaryngology Head and Neck Surgery, The First Affiliated Hospital of Zhengzhou University, No. 1, Eastern Jianshe Road, Zhengzhou, 450052, Henan, China.

This study aimed to investigate the role and regulatory mechanism of RNF126 in nasopharyngeal carcinoma. Firstly, the expression and prognosis of RNF126 were analyzed by TCGA database. The expression of RNF126 was further verified by NPC tissue samples and cells. Read More

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[Pre- and post-chemotherapy tumor volumes: New prognostic factors in nasopharyngeal carcinoma].

Cancer Radiother 2022 Jun 15. Epub 2022 Jun 15.

Service de radiothérapie carcinologique, CHU de Habib-Bourguiba, Sfax, Tunisie.

Purpose: The pre- and post-induction chemotherapy tumor volumes of nasopharyngeal carcinomas may be prognostic indicators for adapting the therapeutic strategy. The objective of our study is to assess the prognostic impact of pre- and post-induction chemotherapy volumes in patients treated for locally advanced nasopharyngeal carcinomas.

Patients And Methods: This is a retrospective study including 52 patients with locally advanced nasopharyngeal carcinoma treated with 3 courses of induction chemotherapy (TPF) followed by intensity modulated radiotherapy associated with concomitant chemotherapy. Read More

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Shuanghua decoction exerts anticancer activity by activating NLRP3 inflammasome via ROS and inhibiting NF-κB signaling in hepatocellular carcinoma cells.

Phytomedicine 2022 Aug 10;103:154249. Epub 2022 Jun 10.

School of Pharmacy, Health Science Center, Xi'an Jiaotong University, Xi'an 710061, P.R. China; State Key Laboratory of Shaanxi for Natural Medicines Research and Engineering, Xi'an, 710061, P. R. China. Electronic address:

Background: Hepatocellular carcinoma (HCC) is a major subtype of liver cancer, with a high mortality rate, and close relation to chronic hepatitis. The components of the NLRP3 inflammasome are poorly expressed or even lost in HCC. Downregulation of the NLRP3 inflammasome expression significantly affects the clinical stages and pathological grade of HCC. Read More

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A prediction model for xerostomia in locoregionally advanced nasopharyngeal carcinoma patients receiving radical radiotherapy.

BMC Oral Health 2022 Jun 17;22(1):239. Epub 2022 Jun 17.

Department of Oncology Radiotherapy, Zhongshan City People's Hospital, No.2 Sunwen Middle Road, Shiqi District, Zhongshan City, 528403, Guangdong, China.

Background: This study was to evaluate the predictors of xerostomia and Grade 3 xerostomia in locoregionally advanced nasopharyngeal carcinoma (NPC) patients receiving radical radiotherapy and establish prediction models for xerostomia and Grade 3 xerostomia based on the predictors.

Methods: Totally, 365 patients with locoregionally advanced NPC who underwent radical radiotherapy were randomly divided into the training set (n = 255) and the testing set (n = 110) at a ratio of 7:3. All variables were included in the least absolute shrinkage and selection operator regression to screen out the potential predictors for xerostomia as well as the Grade 3 xerostomia in locoregionally advanced NPC patients receiving radical radiotherapy. Read More

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Acupuncture for abducens nerve palsy after radiochemotherapy: a CARE-compliant case report.

Explore (NY) 2022 Jun 11. Epub 2022 Jun 11.

Key Laboratory of Acupuncture and Neurology of Zhejiang Province, The Third School of Clinical Medicine (School of Rehabilitation Medicine), Zhejiang Chinese Medical University, Hangzhou, China; Department of Acupuncture and Moxibustion, The Third Affiliated Hospital of Zhejiang Chinese Medical University (Zhongshan Hospital of Zhejiang Province), Hangzhou, China. Electronic address:

Background: Delayed abducens nerve palsy after chemoradiotherapy for nasopharyngeal carcinoma (NPC) is often accompanied by ocular ischemia and cranial nerve damage, thereby increasing the risk of conventional strabismus surgery. Therefore, patients often prefer conservative treatment. Herein we report a case of acupuncture for delayed abducens nerve palsy after chemoradiotherapy for NPC. Read More

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