21,656 results match your criteria Nasopharyngeal Cancer


Can neoadjuvant chemotherapy improve survival in stage T3-4N1 nasopharyngeal carcinoma? A propensity matched analysis.

Radiat Oncol 2020 Jul 2;15(1):160. Epub 2020 Jul 2.

Department of Radiation Oncology, Sun Yat-sen University Cancer Center, State Key Laboratory of Oncology in South China, Collaborative Innovation Center for Cancer Medicine, No. 651 Dongfeng Road East, Guangzhou, 510060, People's Republic of China.

Background: To estimate the efficacy of neoadjuvant chemotherapy (NCT) in stage T3-4N1 nasopharyngeal carcinoma (NPC).

Methods: Data on stage T3-4N1 NPC patients treated with concurrent chemoradiotherapy (CCRT) with or without NCT at the Sun Yat-sen University Cancer Center between January 2006 and December 2013 were retrospectively reviewed. Propensity score matching (PSM) was carried out to balance prognostic factors in NCT followed by CCRT (NCT + CCRT) group and CCRT group in a 1:1 ratio. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1186/s13014-020-01594-4DOI Listing

Development of a self-constrained 3D DenseNet model in automatic detection and segmentation of nasopharyngeal carcinoma using magnetic resonance images.

Oral Oncol 2020 Jun 29;110:104862. Epub 2020 Jun 29.

Sun Yat-sen University Cancer Center, State Key Laboratory of Oncology in South China, Collaborative Innovation Center for Cancer Medicine, Guangdong Key Laboratory of Nasopharyngeal Carcinoma Diagnosis and Therapy, Guangzhou 510060, PR China; Department of Information, Sun Yat-Sen University Cancer Center, Guangzhou 510060, PR China; Precision Medicine Center, Sun Yat-Sen University Cancer Center, Guangzhou 510060, PR China. Electronic address:

Objectives: We aimed to develop a dual-task model to detect and segment nasopharyngeal carcinoma (NPC) automatically in magnetic resource images (MRI) based on deep learning method, since the differential diagnosis of NPC and atypical benign hyperplasia was difficult and the radiotherapy target contouring of NPC was labor-intensive.

Materials And Methods: A self-constrained 3D DenseNet (SC-DenseNet) architecture was improved using separated training and validation sets. A total of 4100 individuals were finally enrolled and split into the training, validation and test sets at a proximate ratio of 8:1:1 using simple randomization. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1016/j.oraloncology.2020.104862DOI Listing

Epstein-Barr Virus (EBV) Based Nasopharyngeal Carcinoma (NPC) Risk Prediction Scores are Elevated in NPC Multiplex Family Members Compared to the General Population in Taiwan.

J Infect Dis 2020 Jul 2. Epub 2020 Jul 2.

Infections and Immunoepidemiology Branch, Division of Cancer Epidemiology and Genetics, National Cancer Institute, Bethesda, MD, USA.

Nasopharyngeal carcinoma (NPC) is caused by Epstein-Barr virus (EBV) and is more likely to occur in susceptible families. Whether genetic susceptibility operates through altered EBV control is incompletely understood. A NPC risk prediction model based on 14 EBV markers to compare the risk score distribution in unaffected members from multiplex families with that in population-based controls. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1093/infdis/jiaa385DOI Listing

Evolution of Altered Sense of Smell or Taste in Patients With Mildly Symptomatic COVID-19.

JAMA Otolaryngol Head Neck Surg 2020 Jul 2. Epub 2020 Jul 2.

Guy's and St Thomas' Hospitals, London, United Kingdom.

Importance: An altered sense of smell and taste has been reported to be associated with coronavirus disease 2019 (COVID-19). To understand the evolution of these symptoms during the course of the disease is important to identify patients with persistent loss of smell or taste and estimate the impact of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infection on the burden of olfactory and gustative dysfunctions.

Objective: To evaluate the evolution of the loss of sense of smell and taste in a case series of mildly symptomatic patients with SARS-CoV-2 infection. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1001/jamaoto.2020.1379DOI Listing

[Transnasal endoscopic surgery of choanal atresia after radiotherapy for nasopharyngeal carcinoma].

Zhonghua Er Bi Yan Hou Tou Jing Wai Ke Za Zhi 2020 Jun;55(6):599-603

Department of Otorhinolaryngology Head and Neck Surgery, the First Affiliated Hospital of Nanchang Universty, Nanchang 330006, China.

To discuss the effect of endoscopic dilatation and plasty for choanal atresia after radiotherapy for nasopharyngeal carcinoma. Nineteen patients with choanal atresia who were admitted to the Department of Otorhinolaryngology Head and Neck Surgery of the First Affiliated Hospital of Nanchang University from Jan. 2011 to Dec. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.3760/cma.j.cn115330-20190707-00429DOI Listing

MiR-34a Inhibits Cell Proliferation and Induces Apoptosis in Human Nasopharyngeal Carcinoma by Targeting lncRNA MCM3AP-AS1.

Cancer Manag Res 2020 22;12:4799-4806. Epub 2020 Jun 22.

Department of Oncology, Liuzhou Hospital of Traditional Chinese Medicine, Liuzhou City, Guangxi Province 545001, People's Republic of China.

Introduction: MCM3AP-AS1 has been characterized as an oncogenic lncRNA in several types of cancer, while its role in nasopharyngeal carcinoma (NPC) is unknown. This study aimed to investigate the role of MCM3AP-AS1 in NPC.

Patients And Methods: Paired NPC tissues and non-tumor tissues were collected from 55 NPC patients. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.2147/CMAR.S245520DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7319531PMC

MicroRNA-379-5p/YBX1 Axis Regulates Cellular EMT to Suppress Migration and Invasion of Nasopharyngeal Carcinoma Cells.

Cancer Manag Res 2020 9;12:4335-4346. Epub 2020 Jun 9.

Department of Otolaryngology, Maternal and Child Health Care Hospital of Hubei Province and Women and Children's Hospital of Hubei Province, Wuhan 430070, People's Republic of China.

Background: Epithelial-mesenchymal transition (EMT) is a major actor modulating the metastasis of nasopharyngeal carcinoma (NPC). Increasing evidence indicates that microRNAs (miRs) are the important regulators of EMT program. However, the potential roles and underlying mechanisms of miR‑379-5p in regulating EMT of NPC cells remain unclear. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.2147/CMAR.S253504DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7293412PMC

SSPH I, a Novel Anti-Cancer Saponin, Inhibits Autophagy and Induces Apoptosis via ROS Accumulation and ERK1/2 Signaling Pathway in Hepatocellular Carcinoma Cells.

Onco Targets Ther 2020 23;13:5979-5991. Epub 2020 Jun 23.

School of Pharmacy, Guangxi Medical University, Nanning, People's Republic of China.

Introduction: Saponin of Hance I (SSPH I), a novel bioactive phytochemical isolated from the rhizomes of , has been demonstrated to exhibit anti-cancer activity against various tumors in preclinical studies. However, the molecular mechanisms involved in the suppression of hepatocellular carcinoma (HCC) are poorly understood. The present study aimed at analyzing the effects of SSPH I on autophagy and apoptosis in vitro. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.2147/OTT.S253234DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7320904PMC

YAP1 Promotes Tumor Invasion and Metastasis in Nasopharyngeal Carcinoma with Hepatitis B Virus Infection.

Onco Targets Ther 2020 17;13:5629-5642. Epub 2020 Jun 17.

Department of Radiation Oncology, Cancer Center, First People's Hospital of Foshan, Foshan 528000, Guangdong Province, People's Republic of China.

Introduction: Nasopharyngeal carcinoma (NPC) patients with HBsAg (+) commonly present with high frequencies of distant metastasis and poor survival rate; however, the mechanism has not been elucidated.

Materials And Methods: We analyzed the yes-associated protein 1 (YAP1) expression between HBsAg (+) and HBsAg (-) of NPC patients, then analyzed the relationship of YAP1 with survival. We further explored the anti-tumor role in NPC cell lines using YAP1 siRNA technique, and checked whether YAP1 regulatesepithelial-mesenchymal transition ( EMT). Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.2147/OTT.S247699DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7306475PMC

Long Noncoding RNA SNHG12 Indicates the Prognosis and Accelerates Tumorigenesis of Diffuse Large B-Cell Lymphoma Through Sponging microR-195.

Onco Targets Ther 2020 12;13:5563-5574. Epub 2020 Jun 12.

Department of Hematology, The 2nd Affiliated Hospital of Harbin Medical University, Harbin 150001, Heilongjiang, People's Republic of China.

Background: Small nucleolar RNA host gene 12 (SNHG12) expression is associated with multiple cancers, including renal cell carcinoma, prostate cancer, cervical cancer, nasopharyngeal carcinoma, colorectal cancer, and hepatocellular carcinoma. However, SNHG12 biological function is unclear in diffuse large B-cell lymphoma (DLBCL).

Methods: SNHG12 expression and associated clinicopathological characteristics were evaluated in DLBCL tissues. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.2147/OTT.S249429DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7305849PMC

LncRNA Promotes Expression by Adsorbing to Suppress Nasopharyngeal Carcinoma Cell Progression.

Onco Targets Ther 2020 20;13:4397-4409. Epub 2020 May 20.

Department of Stomatology, People's Hospital of Longhua, Shenzhen 518109, Guangdong, People's Republic of China.

Background: Recently, long non-coding RNAs (lncRNAs) have been elucidated to play essential roles in cancers, and the recognition of lncRNA expression patterns in nasopharyngeal carcinoma (NPC) may be helpful for indicating novel mechanisms underlying NPC carcinogenesis. Herein, we conducted this study to probe into the function of lncRNA in NPC progression with the involvement of () and actin-binding LIM protein 1 ().

Materials And Methods: In silico analysis screened differentially expressed genes and miRNAs in NPC and predicted potential mechanisms. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.2147/OTT.S245554DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7248807PMC

Correction: Generation of novel affibody molecules targeting the EBV LMP2A N-terminal domain with inhibiting effects on the proliferation of nasopharyngeal carcinoma cells.

Cell Death Dis 2020 Jun 30;11(6):494. Epub 2020 Jun 30.

Institute of Molecular Virology and Immunology, Department of Microbiology and Immunology, School of Basic Medical Sciences, Wenzhou Medical University, 325035, Zhejiang, Wenzhou, China.

An amendment to this paper has been published and can be accessed via a link at the top of the paper. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1038/s41419-020-2692-9DOI Listing

Teaching Neuroimages: Rare skull base involvement in neurosarcoidosis.

Neurology 2020 Jun 30. Epub 2020 Jun 30.

Department of Neurology, The Royal London Hospital, London, UK

A 57-year-old woman was admitted with a tonic-clonic seizure on a background of systemic sarcoidosis with uveitis and hilar lymphadenopathy. She had previously been well and stopped steroids one year before presentation. CT showed a sclerotic lesion with focal lucent areas in the skull base MRI revealed a frontal FLAIR hyperintense oedematous lesion with meningeal enhancement in gadolinium T1 This appearance on imaging evokes broad differential diagnoses such as sarcoidosis, fungal (although she had increasing lesion size despite six-month treatment with amphotericin B), craniofacial fibrous dysplasia, atypical lymphoma, nasopharyngeal carcinoma, myeloma and tuberculosis, therefore necessitating biopsy for definitive evaluation. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1212/WNL.0000000000010082DOI Listing

Repurposing the FDA-Approved Antiviral Drug Ribavirin as Targeted Therapy for Nasopharyngeal Carcinoma.

Mol Cancer Ther 2020 Jun 30. Epub 2020 Jun 30.

Hunterian Neurosurgical Research Laboratory, Department of Neurosurgery, Johns Hopkins University School of Medicine

Nasopharyngeal carcinoma (NPC) is a squamous cell carcinoma with a proclivity for systemic dissemination, leading many patients to present with advanced-stage disease and fail available treatments. There is a notable lack of targeted therapies for NPC, despite working knowledge of multiple proteins with integral roles in NPC cancer biology. These proteins include EZH2, Snail, eIF4E, and IMPDH, which are all overexpressed in NPC and correlated with poor prognosis. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1158/1535-7163.MCT-19-0572DOI Listing

Verification of the machine delivery parameters of treatment plan via deep learning.

Phys Med Biol 2020 Jun 30. Epub 2020 Jun 30.

Radiation Oncology, Stanford University, Stanford, California, UNITED STATES.

We developed a generative adversarial network (GAN)-based deep learning approach to estimate the multileaf collimator (MLC) aperture and corresponding monitor units (MUs) from a given three dimensional (3D) dose distribution. The proposed design of adversari-al network, which integrates a residual block into pix2pix framework, jointly trains a "U-Net"-like architecture as generator and a convolutional "PatchGAN" classifier as dis-criminator. 199 patients, including nasopharyngeal, lung and rectum, treated with intensi-ty modulated radiotherapy (IMRT) and volumetric modulated arc therapy (VMAT) tech-niques were utilized to train the network. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1088/1361-6560/aba165DOI Listing

Prognostic value and the potential role of treatment options for cervical lymph node necrosis in nasopharyngeal carcinoma.

Oral Oncol 2020 Jun 27;109:104864. Epub 2020 Jun 27.

State Key Laboratory of Oncology in South China, Collaborative Innovation Center for Cancer Medicine, Guangzhou, Guangdong 510060, People's Republic of China; Department of Nasopharyngeal Carcinoma, Sun Yat-sen University Cancer Centre, Guangzhou, Guangdong 510060, People's Republic of China. Electronic address:

Objective: There were few studies focused on the cervical lymph necrosis (CNN) of nasopharyngeal carcinoma (NPC) patients to develop a nomogram and guide the treatment decision at the era of intensity modulated radiation therapy (IMRT).

Material And Methods: The prognostic accuracy of CNN in the training cohort (n = 1940) was validated in Guangzhou internal validation cohort (n = 832) and two external validation cohorts (Dongguan, n = 232; Foshan, n = 134).

Results: The primary end point was progression-free survival (PFS), calculated using the Kaplan-Meier method. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1016/j.oraloncology.2020.104864DOI Listing

Radiation-induced second primary squamous cell carcinoma of the oral cavity after radiotherapy for nasopharyngeal carcinoma.

Oral Oncol 2020 Jun 27;109:104863. Epub 2020 Jun 27.

State Key Laboratory of Oncology in South China, Collaborative Innovation Center for Cancer Medicine, Department of Head and Neck Surgery, Sun Yat-sen University Cancer Center, Guangzhou, Guangdong 510060, PR China. Electronic address:

Background: The increasing occurrence of radiation-induced second primary squamous cell carcinoma of the oral cavity (RISCCO) after radiotherapy for nasopharyngeal carcinoma (NPC) has become a noteworthy complication that can influence long-term survival. This study aimed to analyze the associations of clinicopathologic characteristics with prognostic factors among patients who developed RISCCO after radiotherapy for NPC.

Methods: A total of 41,446 NPC patients admitted to Sun Yat-sen University Cancer Center (SYSUCC) between August 1989 and January 2019 were reviewed. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1016/j.oraloncology.2020.104863DOI Listing

Development and validation of immune inflammation-based index for predicting the clinical outcome in patients with nasopharyngeal carcinoma.

J Cell Mol Med 2020 Jun 30. Epub 2020 Jun 30.

Department of Laboratory Medicine, Zhongnan Hospital of Wuhan University, Wuhan University, Wuhan, China.

Inflammation indicators, such as systemic inflammation response index (SIRI), systemic immune-inflammation index (SII), neutrophil-to-lymphocyte ratio (NLR) and platelet-lymphocyte ratio (PLR), are associated with poor prognosis in various solid cancers. In this study, we investigated the predictive value of these inflammation indicators in nasopharyngeal carcinoma (NPC). This retrospective study involved 559 patients with NPC and 500 patients with chronic rhinitis, and 255 NPC patients were followed up successfully. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1111/jcmm.15097DOI Listing

Establishment of prognostic nomograms based on skeletal muscle index and serum biomarker in breast cancer patients receiving radiotherapy.

Clin Transl Med 2020 Jun 30. Epub 2020 Jun 30.

Department of Medical Oncology, SunYat-sen University Cancer Center, State Key Laboratory of Oncology in South China, Collaborative Innovation Center for Cancer Medicine, Guangdong Key Laboratory of Nasopharyngeal Carcinoma Diagnosis and Therapy, Guangzhou, China.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1002/ctm2.115DOI Listing

NCI-Clinical Trial Accrual in a Community Network Affiliated with a Designated Cancer Center.

J Clin Med 2020 Jun 24;9(6). Epub 2020 Jun 24.

City of Hope Comprehensive Cancer Center, Department of Medical Oncology and Developmental Therapeutics, Duarte, CA 91010, USA.

Most cancer care is delivered in the community, while most clinical trials exist in academic centers. We analyzed clinical trial accrual of a tertiary care cancer center and its affiliated community sites to better understand what types of trials accrued at the community sites and whether community accrual increased ethnic diversity. The institutional clinical trial database was searched for solid tumor accruals during 2018-2019. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.3390/jcm9061970DOI Listing

Recommendations for surgical management of recurrent nasopharyngeal carcinoma during COVID-19 pandemic.

Laryngoscope Investig Otolaryngol 2020 Jun 13;5(3):468-472. Epub 2020 Jun 13.

Division of Head and Neck Surgery, Department of Surgery University of Hong Kong Li Ka Shing Faculty of Medicine, Queen Mary Hospital Hong Kong SAR China.

Nasopharyngeal carcinoma is endemic in southern parts of China including Hong Kong. Primary treatment entails radiotherapy ± chemotherapy depending on disease stage at presentation. Surgery is offered as a means of salvage for persistent and recurrent disease. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1002/lio2.417DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7314480PMC

Quality of Life, Toxicity and Unmet Needs in Nasopharyngeal Cancer Survivors.

Front Oncol 2020 12;10:930. Epub 2020 Jun 12.

Sir Peter MacCallum Department of Oncology, The University of Melbourne, Melbourne, VIC, Australia.

Concerted research efforts over the last three decades have resulted in improved survival and outcomes for patients diagnosed with nasopharyngeal carcinoma (NPC). The evolution of radiotherapy techniques has facilitated improved dose delivery to target volumes while reducing dose to the surrounding normal tissue, improving both disease control and quality of life (QoL). In parallel, clinical trials focusing on determining the optimal systemic therapy to use in conjunction with radiotherapy have been largely successful, resulting in improved locoregional, and distant control. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.3389/fonc.2020.00930DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7303258PMC

Gene Signatures and Prognostic Values of mA Genes in Nasopharyngeal Carcinoma.

Front Oncol 2020 11;10:875. Epub 2020 Jun 11.

National Clinical Research Center for Geriatric Disorders, Xiangya Hospital, Central South University, Changsha, China.

Nasopharyngeal carcinoma (NPC) is a malignant tumor with a high rate of local invasion and early distant metastasis. Accumulating studies suggest that N6-methyladenosine methylation (mA) is closely related to tumorigenesis. However, the relationship between mA-related genes and prognosis of NPC is poorly understood. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.3389/fonc.2020.00875DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7300221PMC

Study on the Drug Targets and Molecular Mechanisms of in the Treatment of Nasopharyngeal Carcinoma Based on Network Pharmacology.

Evid Based Complement Alternat Med 2020 28;2020:2606402. Epub 2020 Mar 28.

Department of Otolaryngology & Head and Neck Surgery, The Second Affiliated Hospital of Guangxi Medical University, Nanning City, Guangxi Zhuang Autonomous Region 530000, China.

Aim: To analyse the target of in nasopharyngeal carcinoma by using network pharmacological techniques and to explore the associated molecular mechanism.

Methods: The targets of nasopharyngeal carcinoma were retrieved from the GeneCards database. At the same time, the drug therapeutic targets of were obtained from the TCMSP and SymMap databases. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1155/2020/2606402DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7301251PMC

Characteristics and Impact of HPV-Associated p16 Expression on Head and Neck Squamous Cell Carcinoma in Thai Patients.

Asian Pac J Cancer Prev 2020 Jun 1;21(6):1679-1687. Epub 2020 Jun 1.

Division of Medical Oncology, Department of Medicine, Faculty of Medicine Ramathibodi Hospital, Mahidol University, Bangkok, Thailand.

Background: Head and neck squamous cell carcinoma (HNSCC) is a common malignancy in Asia. Infection by human papilloma virus (HPV) has been recognized as an etiological risk for HNSCC, especially oropharyngeal region. While the association between HPV and HNSCC has been well evaluated in Western countries, only a few investigated the HPV-associated HNSCC in Southeast Asia. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.31557/APJCP.2020.21.6.1679DOI Listing

TIPE1-mediated autophagy suppression promotes nasopharyngeal carcinoma cell proliferation via the AMPK/mTOR signalling pathway.

J Cell Mol Med 2020 Jun 25. Epub 2020 Jun 25.

Central of Translation Medicine, Zibo Central Hospital, Shandong University, Zibo, China.

Recent studies have shown that tumour necrosis factor-α-induced protein 8 like-1(TIPE1) plays distinct roles in different cancers. TIPE1 inhibits tumour proliferation and metastasis in a variety of tumours but acts as an oncogene in cervical cancer. The role of TIPE1 in nasopharyngeal carcinoma (NPC) remains unknown. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1111/jcmm.15550DOI Listing

Pre-treatment amide proton transfer imaging predicts treatment outcome in nasopharyngeal carcinoma.

Eur Radiol 2020 Jun 25. Epub 2020 Jun 25.

Medical Physics and Research Department, Hong Kong Sanatorium & Hospital, Happy Valley, Hong Kong, S.A.R., China.

Objective: To investigate the value of pre-treatment amide proton transfer-weighted (APTw) imaging for predicting survival of patients with nasopharyngeal carcinoma (NPC).

Materials And Methods: Pre-treatment APTw imaging was performed in 77 NPC patients and the mean, 90th percentile, skewness, and kurtosis of APT asymmetry (APT, APT, APT, and APT, respectively) were obtained from the primary tumor. Associations of APTw parameters with locoregional relapse-free survival (LRRFS), distant metastasis-free survival (DMFS), and disease-free survival (DFS) after 2 years were assessed by univariable Cox regression analysis and significant APTw parameters, together with age, sex, treatment, and stage as confounding variables, were added to the multivariable model. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1007/s00330-020-06985-5DOI Listing

Risk stratification for nasopharyngeal carcinoma: a real-world study based on locoregional extension patterns and Epstein-Barr virus DNA load.

Ther Adv Med Oncol 2020 12;12:1758835920932052. Epub 2020 Jun 12.

Department of Molecular Diagnostics, Sun Yat-sen University Cancer Center, State Key Laboratory of Oncology in South China, Guangdong Key Laboratory of Nasopharyngeal Carcinoma Diagnosis and Therapy, Collaborative Innovation Center for Cancer Medicine, 651 Dongfeng East Road, Guangzhou, 510060, People's Republic of China.

Aim: The present study aimed to evaluate the combined value of locoregional extension patterns (LEPs) and circulating cell-free Epstein-Barr virus (cf EBV) DNA for risk stratification of locoregionally advanced nasopharyngeal carcinoma (LA-NPC) to better guide therapeutic strategies.

Methods: A total of 7227 cases of LA-NPC were reviewed retrospectively and classified into six groups according to their LEP (ascending, descending, or mixed type) and pre-treatment cf EBV-DNA load (⩾ <4000 copy/ml). Using a supervised statistical clustering approach, patients in the six groups were clustered into low, intermediate, and high-risk clusters. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1177/1758835920932052DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7294474PMC

MiR-34c downregulation leads to SOX4 overexpression and cisplatin resistance in nasopharyngeal carcinoma.

BMC Cancer 2020 Jun 26;20(1):597. Epub 2020 Jun 26.

Princess Margaret Cancer Centre, University Health Network, Toronto, Canada.

Background: A major cause of disease-related death in nasopharyngeal carcinoma (NPC) is the development of distant metastasis (DM) despite combination chemoradiotherapy treatment. We previously identified and validated a four microRNA (miRNA) signature that is prognostic for DM. In this study, characterization of a key component of this signature, miR-34c, revealed its role in chemotherapy resistance. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1186/s12885-020-07081-zDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7318489PMC

The predictive value of serum lipids for eye metastases in male nasopharyngeal carcinoma patients.

Authors:
Zhen Xie Yi Shao

Biosci Rep 2020 Jun;40(6)

Department of Ophthalmology, The First Affiliated Hospital of Nanchang University, Jiangxi Province Ocular Disease Clinical Research Center, Nanchang 330006, Jiangxi, People's Republic of China.

Background: Nasopharyngeal carcinoma (NPC) is a tumor that is commonly found in southern China. NPC has several risk factors, such as infection with the Epstein-Barr virus. However, we know little about the risk factors for eye metastasis (EM) in male patients with NPC. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1042/BSR20201082DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7317591PMC

Automatic T Staging Using Weakly Supervised Deep Learning for Nasopharyngeal Carcinoma on MR Images.

J Magn Reson Imaging 2020 Jun 24:e27202. Epub 2020 Jun 24.

Department of Radiation Oncology, Fudan University Shanghai Cancer Center, Shanghai, China.

Background: Recent studies have shown that deep learning can help tumor staging automatically. However, automatic nasopharyngeal carcinoma (NPC) staging is difficult due to the lack of large and slice-level annotated datasets.

Purpose: To develop a weakly-supervised deep-learning method to predict NPC patients' T stage without additional annotations. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1002/jmri.27202DOI Listing

The prognostic value of excision repair cross-complementing Group 1 expression in nasopharyngeal cancer patients.

J Res Med Sci 2020 13;25:34. Epub 2020 Apr 13.

Department of Otolaryngology, Faculty of Medicine, Chiang Mai University, Chiang Mai, Thailand.

Background: Overexpression of excision repair cross-complementing Group 1 (ERCC-1) is related to cisplatin resistance and defective repair of radiation damage. The purpose of this study was to evaluate the clinical significance of excision (ERCC-1) expression in nasopharyngeal cancer (NPC).

Materials And Methods: We conducted a retrospective review of patients diagnosed with NPC between 2000 and 2013. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.4103/jrms.JRMS_787_18DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7306241PMC
April 2020
0.608 Impact Factor

Combination of Plasma MIF and VCA-IgA Improves the Diagnostic Specificity for Patients With Nasopharyngeal Carcinoma.

Technol Cancer Res Treat 2020 Jan-Dec;19:1533033820935773

Department of Clinical Laboratory, Affiliated Tumor Hospital of Zhengzhou University, Henan Tumor Hospital, Zhengzhou, China.

Introduction: The purpose of this study is to evaluate the diagnostic value of macrophage migration inhibitory factor in patients with nasopharyngeal carcinoma.

Materials And Methods: The expression levels of macrophage migration inhibitory factor in nasopharyngeal carcinoma cell lines, tumor tissues, and plasma were measured by real-time polymerase chain reaction, Western blotting, enzyme-linked immunosorbent assay, and immunohistochemistry. Plasma Epstein-Barr virus viral capsid antigen was determined by immunoenzymatic techniques. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1177/1533033820935773DOI Listing

Nasopharyngeal carcinoma in children and young adults-Beyond 5-year survival.

Pediatr Blood Cancer 2020 Jun 23:e28494. Epub 2020 Jun 23.

Division of Pediatric Hematology/Oncology, Ruth Rappaport Children's Hospital, Rambam Health Care Campus, Haifa, Israel.

Nasopharyngeal carcinoma (NPC) is a rare and locally aggressive form of childhood cancer. Treatment of NPC includes chemotherapy and radiotherapy. With current treatment protocols, survival rates for patients with nonmetastatic disease is over 80%. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1002/pbc.28494DOI Listing

Mechanisms of Epstein-Barr virus nuclear antigen 1 favor Tregs accumulation in nasopharyngeal carcinoma.

Cancer Med 2020 Jun 22. Epub 2020 Jun 22.

Department of Otolaryngology, Head and Neck Surgery, Nanfang Hospital, Southern Medical University, Guangzhou, China.

Background: Documented reports proved that Epstein-Barr virus (EBV) infection increased infiltration of Tregs in malignancy. However, the mechanism of EBV recruitment Tregs into nasopharyngeal carcinoma (NPC) tissues has not been detailed discussion.

Methods: Expression of EBV nuclear antigen 1 (EBNA1) and Foxp3 in NPC tissue samples was detected by immunohistochemistry. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1002/cam4.3213DOI Listing

Salinomycin enhances radiotherapy sensitivity and reduces expressions of BIRC5 and NEIL2 in nasopharyngeal carcinoma.

Eur Rev Med Pharmacol Sci 2020 Jun;24(11):6409-6416

Department of Radiotherapy, Linyi Cancer Hospital, Linyi, China.

Objective: The aim of this study was to investigate the effects of salinomycin (Sal) on expressions of baculoviral IAP repeat-containing 5 (BIRC5) and Nei endonuclease VIII-like 2 (NEIL2) and radiotherapy sensitivity of nasopharyngeal carcinoma (NPC).

Materials And Methods: Human NPC CNE-2 cell lines were used as research objects in this study. Subsequently, the cells received intervention with Sal at different concentrations, radioactive rays at different doses and Sal combined with radioactive rays. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.26355/eurrev_202006_21539DOI Listing

Nasopharyngeal Cancer: Prevalence, Outcome, and Impact on Health-Related Quality of Life at Princess Norah Oncology Center, Jeddah, Saudi Arabia.

Cureus 2020 May 19;12(5):e8199. Epub 2020 May 19.

Urology, King Saud Bin Abdulaziz University for Health Sciences / International Medical Center, Jeddah, SAU.

Introduction Head and neck malignancies are considered among the most common cancers that arise from different anatomical sites in the region. The number of new cases diagnosed worldwide each year is estimated to be more than 550,000 resulting in about 380,000 deaths. One of these head and neck cancers that may affect patient quality of life is the nasopharyngeal carcinoma (NPC). Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.7759/cureus.8199DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7302723PMC

MRI of benign hyperplasia in the nasopharynx: is there an association with Epstein-Barr virus?

Clin Radiol 2020 Jun 19. Epub 2020 Jun 19.

Department of Chemical Pathology, The Chinese University of Hong Kong, Shatin, New Territories, Hong Kong SAR, China; Li Ka Shing Institute of Health Sciences, The Chinese University of Hong Kong, Shatin, New Territories, Hong Kong SAR, China.

Aim: To evaluate whether there is an association between persistently positive plasma Epstein-Barr virus (EBV) DNA and the presence and the change in benign hyperplasia.

Materials And Methods: One hundred and seventeen participants with positive-plasma EBV-DNA, but without NPC from previous nasopharyngeal carcinoma (NPC) screening, underwent follow-up magnetic resonance imaging (MRI) and plasma EBV-DNA after 2 years. Logistic regression was used to analyse associations between MRI (benign hyperplasia on the follow-up MRI and change from 2 years earlier), and plasma EBV-DNA, smoking, and age. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1016/j.crad.2020.05.011DOI Listing

Occult SARS-CoV-2 infection; a possible hypothesis for viral relapse.

Med Hypotheses 2020 Jun 8;144:109980. Epub 2020 Jun 8.

Clinical Research Management Program, Edson College, Arizona State University, USA; Faculty of Medicine, Zagazig University, Sharkia, Egypt. Electronic address:

Coronavirus disease 2019 (COVID-19) has emerged as a global public health emergency, which is characterized by high infection rate and fatal course. Recent data reported that the test for Severe Acute Respiratory Syndrome Coronavirus-2 (SARS-CoV-2) RNA might become positive again after one or two consecutively negative tests. Many researchers are currently evaluating the clinical characteristics of the SARS-CoV-2 reactivation. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1016/j.mehy.2020.109980DOI Listing

Practical Guide for Identification of Internal Carotid Artery During Endoscopic Nasopharyngectomy.

Laryngoscope 2020 Jun 22. Epub 2020 Jun 22.

Division of Otorhinolaryngology, Department of Biotechnology and Life Sciences, University of Insubria, Territorial Social Health Companies of the Seven Lakes, Circolo Hospital and Macchi Foundation, Varese, Italy.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1002/lary.28778DOI Listing

FOXD1, negatively regulated by miR-186, promotes the proliferation, metastasis and radioresistance of nasopharyngeal carcinoma cells.

Cancer Biomark 2020 Jun 12. Epub 2020 Jun 12.

Background: Foxhead box D1 (FOXD1) is validated to be over-expressed in a variety of human malignancies and promotes cancer progression. Nevertheless, the role of FOXD1 and the associated mechanism in nasopharyngeal carcinoma (NPC) remain largely unknown.

Methods: A total of seventy-five cases of NPC tissue samples were collected. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.3233/CBM-191311DOI Listing

TRAF2 Knockdown in Nasopharyngeal Carcinoma Induced Cell Cycle Arrest and Enhanced the Sensitivity to Radiotherapy.

Biomed Res Int 2020 30;2020:1641340. Epub 2020 May 30.

Department of Gastroenterology, Affiliated Tai Zhou Hospital of Wenzhou Medical University, No. 150 Ximen Road, Linhai, Taizhou 317000, China.

TRAF2 is a crucial adaptor protein involved in various signaling pathways. However, its biological functions in nasopharyngeal carcinoma (NPC) remain largely unknown. In the present study, we found that TRAF2 was overexpressed in nasopharyngeal carcinoma (NPC) cells. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1155/2020/1641340DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7277071PMC

Molecular biology of BPIFB1 and its advances in disease.

Ann Transl Med 2020 May;8(10):651

Key Laboratory of Shenzhen Respiratory Disease, Shenzhen Institute of Respiratory Disease, Shenzhen People's Hospital (The First Affiliated Hospital of Southern University of Science and Technology, The Second Clinical Medical College of Jinan University), Shenzhen, China.

Bactericidal/permeability-increasing (BPI)-fold-containing family B member 1 (BPIFB1), also known as long-palate lung and nasal epithelium clone 1 (LPLUNC1), belongs to the BPI-fold-containing family, is a newly discovered natural immune protection molecule, which, having the function of bactericidal and osmotic enhancement protein domain, can respond to the external physical and chemical stimuli. The gene of BPIFB1 is located at chromosome 20q11.21-20q11. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.21037/atm-20-3462DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7290611PMC

Detection of SARS-CoV-2 by bronchoscopy after negative nasopharyngeal testing: Stay vigilant for COVID-19.

Respir Med Case Rep 2020 8;30:101120. Epub 2020 Jun 8.

Department of Laboratory Medicine, University of Washington School of Medicine, Seattle, WA, USA.

Purpose: Real-time polymerase chain reaction (RT-PCR) detection of severe acute respiratory syndrome coronavirus (SARS-CoV-2) is required for diagnosis of coronavirus disease 2019 (COVID-19). Sensitivity of RT-PCR nasopharyngeal (NP) testing is presumed to be high, but there is no gold standard against which this has been determined. The objective was to determine whether lower respiratory tract infection (LRTI), detected in bronchoalveolar lavage fluid (BALF), occurs in the absence of upper respiratory tract infection with clinical testing of both specimen types. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1016/j.rmcr.2020.101120DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7298516PMC

Taurine Attenuates Carcinogenicity in Ulcerative Colitis-Colorectal Cancer Mouse Model.

Oxid Med Cell Longev 2020 20;2020:7935917. Epub 2020 May 20.

Department of Environmental and Molecular Medicine, Mie University Graduate School of Medicine, Tsu, Mie 514-8507, Japan.

Taurine (2-aminoethane-sulfonic acid) is a type of amino acids and has numerous physiological and therapeutic functions, including anti-inflammation. However, there are few studies on the anticancer action of taurine. Our previous studies have demonstrated that taurine exhibits an apoptosis-inducing effect on human nasopharyngeal carcinoma cells . Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1155/2020/7935917DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7260642PMC

Nodal EBV+ cytotoxic T-cell lymphoma: A literature review based on the 2017 WHO classification.

J Clin Exp Hematop 2020 ;60(2):30-36

Department of Pathology and Laboratory Medicine, Nagoya University Hospital, Nagoya, Japan.

Nodal Epstein-Barr virus (EBV)-positive cytotoxic T-cell lymphoma (CTL) is a primary nodal peripheral T-cell lymphoma (PTCL) characterized by a cytotoxic phenotype and EBV on the tumor cells. This disease reportedly accounts for 21% of PTCL not otherwise specified (NOS). However, few nodal EBV+ lymphomas have been documented in detail. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.3960/jslrt.20001DOI Listing
January 2020

Clinical characteristics and management of a liver transplanted patient admitted with SARS-CoV-2 infection.

Clin Res Hepatol Gastroenterol 2020 Jun 10. Epub 2020 Jun 10.

Division of Infectious Diseases, Ente Ospedaliero Cantonale, Ospedale Civico and Ospedale Italiano, Lugano, Switzerland.

We present here the case of a 62-year-old man, who was referred to the emergency department with fever and cough for 3 days. He underwent liver transplantation 4 years earlier due to HCV and NASH-related cirrhosis with hepatocellular carcinoma. At admission he was in reduced general conditions. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1016/j.clinre.2020.05.014DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7284277PMC