40,644 results match your criteria Nasopharyngeal Cancer


A randomized, double-blind, placebo-controlled trial of probiotics to reduce the severity of oral mucositis induced by chemoradiotherapy for patients with nasopharyngeal carcinoma.

Cancer 2018 Dec 6. Epub 2018 Dec 6.

Institute of Translational Medicine, Nanchang University, Nanchang, People's Republic of China.

Background: The objective of this study was to evaluate the effect of a probiotic combination on the severity of oral mucositis (OM), which is a common, unpreventable complication induced by radiochemotherapy in patients with nasopharyngeal carcinoma who undergo concurrent radiochemotherapy (CCRT).

Methods: Eligible patients (n = 99) with locally advanced nasopharyngeal carcinoma who were undergoing CCRT were randomly assigned (2:1) to receive a probiotic combination or placebo during radiochemotherapy, and the incidence of severe OM (grade 3 or higher) was the primary endpoint.

Results: Patients taking the probiotic combination showed a significant reduction in the severity of OM. Read More

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December 2018

Second infield re-irradiation with a resulting cumulative equivalent dose (EQD2 ) of >180 Gy for patients with recurrent head and neck cancer.

Head Neck 2018 Dec 6. Epub 2018 Dec 6.

Department of Radiation Oncology, Johann Wolfgang Goethe University, Frankfurt, Germany.

Background: For locally recurrent head and neck cancer, re-irradiation with modern techniques like stereotactic body radiotherapy is a promising, possibly curative alternative to palliative systemic therapy.

Methods: We report on 1 patient with nasopharyngeal carcinoma (NPC) and 1 patient with cutaneous squamous cell carcinoma (SCC). Both patients received full dose primary treatment (>66 Gy, EQD2), full dose re-irradiation (>50 Gy, EQD2), and a second course of re-irradiation via robotic radiosurgery (CyberKnife) for a second local recurrence. Read More

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December 2018
2 Reads

Recent advances in the management of nasopharyngeal carcinoma.

F1000Res 2018 21;7. Epub 2018 Nov 21.

Department of Otorhinolaryngology, Head and Neck Surgery, The Chinese University of Hong Kong, Prince of Wales Hospital, Shatin, Hong Kong.

Over the last few years, certain areas in the management nasopharyngeal carcinoma (NPC) that have an impact on the care of these patients have evolved, particularly with regard to liquid biopsies, minimally invasive surgery, and advances in chemotherapy and immunotherapy. Beyond its proven role in the diagnostics, surveillance, and treatment of NPC, liquid biopsy with plasma Epstein-Barr virus DNA in the screening of high-risk populations for NPC is strongly supported by recent evidence. Surgery of the nasopharynx is reserved for locally recurrent NPC, and in recent years there have been great strides in minimally invasive techniques with survival rates similar to those of open techniques in treating NPC. Read More

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November 2018
2 Reads

The Efficacy and Safety of Anti-epidermal Growth Factor Receptor Monoclonal Antibodies in Nasopharyngeal Carcinoma: Literature-based Meta-analyses.

J Cancer 2018 31;9(23):4510-4520. Epub 2018 Oct 31.

Department of Radiation Oncology, Sun Yat-sen University Cancer Centre; State Key Laboratory of Oncology in South China; Collaborative Innovation Centre of Cancer Medicine; Guangdong Key Laboratory of Nasopharyngeal Carcinoma Diagnosis and Therapy, Guangzhou, China.

Anti-epidermal growth factor receptor monoclonal antibodies (anti-EGFR mAbs), such as cetuximab and nimotuzumab have been used in the treatment of nasopharyngeal carcinoma (NPC), yet their efficacy and safety are undetermined. : We performed two meta-analyses based on systematic searches of PubMed, EMBASE, the Cochrane Library and SinoMed: comparison 1 (standard therapy plus mAbs vs. standard therapy) and comparison 2 (radiotherapy plus concurrent mAbs vs. Read More

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October 2018
1 Read

Interplay of Tumor Spread, Volume and Epstein-Barr Virus DNA in Nasopharyngeal Carcinoma: Feasibility of An Integrative Risk Stratification Scheme.

J Cancer 2018 20;9(22):4271-4278. Epub 2018 Oct 20.

Department of Radiation Oncology, Fudan University Shanghai Cancer Center, Shanghai, 200032, China.

To investigate the inter-correlation of tumor spread, volume and quantitative plasma Epstein-Barr virus DNA level (pEBV DNA), and to further assess the prognostic efficacy of a novel risk stratification combining anatomic, volumetric and biological features in nasopharyngeal carcinoma (NPC). One hundred and twelve patients with non-metastatic NPC were prospectively enrolled. Correlation of pEBV DNA with tumor invasiveness, lymph node (LN) metastasis, tumor volume and classification was tested by univariate and multivariate analyses. Read More

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October 2018

Clinical Effect of Adjuvant Cytokine-Induced Killer Cells Immunotherapy in Patients with Stage II-IVB Nasopharyngeal Carcinoma after Chemoradiotherapy: A propensity score analysis.

J Cancer 2018 20;9(22):4204-4214. Epub 2018 Oct 20.

Collaborative Innovation Center for Cancer Medicine, State Key Laboratory of Oncology in South China, Guangdong Key Laboratory of Nasopharyngeal Carcinoma Diagnosis and Therapy, Sun Yat-sen University Cancer Center, Guangzhou, China.

As an adjuvant immunotherapy, cytokine-induced killer cells (CIKs) infusion has been demonstrated to exert potent effectiveness in several types of cancer patients who received curative treatment. However, controversy exists regarding whether nasopharyngeal carcinoma (NPC) patients can benefit from additional treatment after radical radiotherapy or chemoradiotherapy to improve their distant control and survival. In this retrospective study, we aimed to evaluate the efficacy of adjuvant CIK cells therapy in NPC patients with stage II-IVB after curative treatment. Read More

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October 2018

Prognostic value of TIGAR and LC3B protein expression in nasopharyngeal carcinoma.

Cancer Manag Res 2018 12;10:5605-5616. Epub 2018 Nov 12.

Department of Oncology, The Affiliated Hospital of Southwest Medical University, Luzhou 646000, People's Republic of China,

Purpose: Autophagy, the process responsible for degrading cytoplasmic organelles to sustain cellular metabolism, has been associated with cancer initiation and progression. As TP53-induced glycolysis and apoptosis regulator () is among the important genes that can regulate autophagy, we aimed to investigate the correlation between the expression levels of TIGAR and the autophagy-related protein microtubule-associated protein 1 light chain 3 (), as well as their association with clinical outcomes, in nasopharyngeal carcinoma (NPC) patients.

Methods: We detected the expressions of TIGAR and LC3B in 182 NPC tissue samples via immunohistochemical staining. Read More

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November 2018

Osthole sensitizes with radiotherapy to suppress tumorigenesis of human nasopharyngeal carcinoma in vitro and in vivo.

Cancer Manag Res 2018 8;10:5471-5477. Epub 2018 Nov 8.

Department of Cardiology, The Second Affiliated Hospital of Wenzhou Medical University, Wenzhou 325027, Zhejiang, People's Repulic of China,

Background: Radiotherapy is one of the most comment and useful treatment for nasopharyngeal carcinoma (NPC), but the radioresistance remains a major obstacle. Osthole, a natural coumarin derivative, has been shown to have anti-tumor and anti-inflammatory activity. However, the relationship between osthole and NPC treatment, especially for radiotherapy, is still elusive. Read More

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November 2018
1 Read

mA-mediated ZNF750 repression facilitates nasopharyngeal carcinoma progression.

Cell Death Dis 2018 Dec 5;9(12):1169. Epub 2018 Dec 5.

State Key Laboratory of Oncology in South China, Collaborative Innovation Centre of Cancer Medicine, Guangdong Key Laboratory of Nasopharyngeal Carcinoma Diagnosis and Therapy, Sun Yat-sen University Cancer Center, 510060, Guangzhou, China.

Nasopharyngeal carcinoma (NPC) progression is regulated by genetic, epigenetic, and epitranscript modulation. As one of the epitranscript modifications, the role of N6-Methyladenosine (mA) has not been elucidated in NPC. In the present study, we found that the poorly methylated gene ZNF750 (encoding zinc finger protein 750) was downregulated in NPC tumor tissues and cell lines. Read More

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December 2018

Three-dimensional volumetric magnetic resonance imaging (MRI) analysis of the soft palate and nasopharynx in brachycephalic and non-brachycephalic dog breeds.

J Vet Med Sci 2018 Dec 5. Epub 2018 Dec 5.

Section of Medical Imaging, Veterinary Medical Center, Chungbuk National University.

The purpose of this study was to use magnetic resonance imaging (MRI) to compare the volumes and three-dimensional configurations of the soft palate and nasopharynx in non-brachycephalic and brachycephalic dogs with different body weights, and infer which factors influence nasopharyngeal volume. This was a retrospective observational study. The brain MRI medical records of all dogs referred to the Veterinary Medical Center, Chungbuk National University, between 2013 and 2016, for evaluation of intracranial disease were reviewed. Read More

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December 2018
1 Read

Multicenter Clinical Evaluation of the Automated ARIES® Assay.

J Clin Microbiol 2018 Dec 5. Epub 2018 Dec 5.

Marshfield Labs, Marshfield, Wisconsin, USA.

Molecular methods offer superior sensitivity and specificity, and reduce testing turnaround time from days to hours for detection of and In this study, we evaluated the performance of the automated PCR-based ARIES Assay, which detects both and directly from nasopharyngeal swab specimens. Limits of detection were 1,800 colony-forming units/mL (CFU·mL) for and 213 CFU·mL for The assay detected 16/18 unique strains. Of 71 potential cross-reacting organisms, 5 generated false-positives in 1/6 replicates; none of 6 additional spp. Read More

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December 2018

Clinically-oriented Contour Evaluation using Dosimetric Indices Generated from Automated Knowledge-based Planning.

Int J Radiat Oncol Biol Phys 2018 Nov 30. Epub 2018 Nov 30.

Department of Radiation Medicine and Applied Sciences, University of California San Diego, La Jolla, CA. Electronic address:

Purpose: Geometric indicators of contouring accuracy suffer from lack of clinical context in radiotherapy. To provide clinical relevance, treatment plans should be generated from the candidate contours, but manual planning could introduce confounding variations. Therefore, our objectives in this study were to: (i) determine the feasibility of using automated knowledge-based planning (KBP) as an objective tool to generate dosimetric parameters for contour evaluation, (ii) evaluate the correlation between geometric indices and dosimetric endpoints, and (iii) report the dosimetric impact of multiple observations of resident-contoured head-and-neck target and organ-at-risk (OAR) volumes. Read More

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November 2018

Indications and endonasal treatment of petrous apex cholesterol granulomas.

Curr Opin Otolaryngol Head Neck Surg 2018 Nov 30. Epub 2018 Nov 30.

Division of Rhinology, Department of Otorhinolaryngology-Head and Neck Surgery, University of Pennsylvania, Perelman School of Medicine, Philadelphia, Pennsylvania, USA.

Purpose Of Review: Lesions of the petrous apex of the temporal bone can be challenging to access and approaches laterally through the mastoid as well as medially through an endonasal approach are utilized to access this region while preserving function of adjacent structures. Cholesterol granulomas of the petrous apex requiring surgery are marsupialized to prevent expansion of the inflamed cyst and relieve associated clinical symptoms. The endonasal approach to the petrous apex has in the past been limited to lesions medial to the internal carotid artery. Read More

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November 2018

Effects of CKMT1 on radiosensitivity of nasopharyngeal carcinoma cells.

Int J Radiat Biol 2018 Dec 3:1-25. Epub 2018 Dec 3.

a Central Lab, First Affiliated Hospital of Fujian Medical University , Fuzhou , Fujian 350005 , China.

Purpose: Radioresistance is an important factor for unsatisfactory prognosis in Nasopharyngeal carcinoma (NPC) patients. Ubiquitous mitochondrial creatine kinase (CKMT1) is always associated with malignancy in a variety of cancers. However, its significance in NPC progression and radiosensitivity remains unclear. Read More

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December 2018
2 Reads

In vitro cytotoxicity evaluation of thiourea derivatives bearing Salix sp. constituent against HK-1 cell lines.

Nat Prod Res 2018 Dec 3:1-10. Epub 2018 Dec 3.

d School of Health Medical and Applied Sciences , Central Queensland University , Norman Gardens , Australia.

In searching for drugs from natural product scaffolds has gained interest among researchers. In this study, a series of twelve halogenated thiourea (ATX 1-12) via chemical modification of aspirin (a natural product derivative) and evaluated for cytotoxic activity against nasopharyngeal carcinoma (NPC) cell lines, HK-1 via MTS-based colorimetric assay. The cytotoxicity studies demonstrated that halogens at meta position of ATX showed promising activity against HK-1 cells (IC value ≤15 µM) in comparison to cisplatin, a positive cytotoxic drug (IC value =8. Read More

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December 2018
2 Reads

Radiation-induced gray matter atrophy in patients with nasopharyngeal carcinoma after intensity modulated radiotherapy: a MRI magnetic resonance imaging voxel-based morphometry study.

Quant Imaging Med Surg 2018 Oct;8(9):902-909

Department of Radiology, Second Affiliated Hospital of Zhejiang University School of Medicine, Hangzhou 310009, China.

Background: Gray matter (GM) damage after radiotherapy (RT) in nasopharyngeal carcinoma (NPC) patients can result in cognitive impairment, while there may be no visible brain tissue change according to the conventional magnetic resonance imaging (MRI). This study investigated radiation-induced GM volume differences between NPC patients who received RT and those who did not.

Methods: High-resolution brain structural MRI data from two groups of patients were acquired. Read More

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October 2018

MRI findings, including diffusion-weighted imaging and apparent diffusion coefficient value, in two cats with nasopharyngeal polyps and one cat with lymphoma.

JFMS Open Rep 2018 Jul-Dec;4(2):2055116918812254. Epub 2018 Nov 27.

Department of Advanced Clinical Medicine, School of Life and Environmental Sciences, Osaka Prefecture University, Izumisano, Osaka, Japan.

Objectives: Most nasopharyngeal masses in cats are lymphomas or polyps. To our knowledge, there is no report of MRI findings, including diffusion-weighted imaging (DWI) or apparent diffusion coefficient (ADC) values, of nasopharyngeal lymphomas and nasopharyngeal polyps in cats. This study aimed to evaluate the MRI findings of nasopharyngeal lymphomas and nasopharyngeal polyps, including DWI and ADC values. Read More

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November 2018

Cytoplasmic LIF reprograms invasive mode to enhance NPC dissemination through modulating YAP1-FAK/PXN signaling.

Nat Commun 2018 Nov 30;9(1):5105. Epub 2018 Nov 30.

Department of Radiation Oncology, Chang Gung Memorial Hospital and University at Lin-Kou, 5, Fuxing St., Guishan Dist., 333, Taoyuan City, Taiwan.

Metastasis remains a clinically unsolved issue in nasopharyngeal carcinoma. Here, we report that higher levels of cytoplasmic leukemia inhibitory factor (LIF) and LIF receptor are correlated with poorer metastasis/recurrence-free survival. Further, single nucleotide variations and signal peptide mutation of LIF are identified in NPC. Read More

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November 2018

Triptonide inhibits human nasopharyngeal carcinoma cell growth via disrupting Lnc-RNA THOR-IGF2BP1 signaling.

Cancer Lett 2018 Nov 29. Epub 2018 Nov 29.

Department of Radiotherapy & Oncology, Kunshan First People's Hospital Affiliated to Jiangsu University, Kunshan, China. Electronic address:

Advanced stage nasopharyngeal carcinoma (NPC) has a poor prognosis. Triptonide ("TN") is a small molecule monomer extract from the ancient Chinese herb Tripterygium wilfordii Hook. We show that TN, at nanomolar concentrations, potently inhibited survival and proliferation of multiple established and primary human NPC cells. Read More

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November 2018
2 Reads

The porcine tonsils and Peyer's patches: A stereological morphometric analysis in conventionally and artificially reared piglets.

Vet Immunol Immunopathol 2018 Dec 13;206:9-15. Epub 2018 Nov 13.

Applied Veterinary Morphology, Department of Veterinary Sciences, Faculty of Pharmaceutical, Biomedical and Veterinary Sciences, University of Antwerp, Universiteitsplein 1, B-2610 Wilrijk, Belgium; Department of Morphology, Faculty of Veterinary Medicine, Ghent University, Salisburylaan 133, B-9820 Merelbeke, Belgium. Electronic address:

Selection for prolificacy in modern pig farming has resulted in increasing litter sizes. Since rearing large litters is challenging, artificial rearing of piglets with a milk replacer is an alternative strategy. It is hypothesized that the development of the piglets' mucosa-associated lymphoid tissues (MALT) is affected by these artificial conditions. Read More

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December 2018

Impact of bedside diagnosis of influenza in the paediatric emergency ward.

Clin Microbiol Infect 2018 Nov 28. Epub 2018 Nov 28.

Groupe Immunité des Muqueuses et Agents Pathogènes (GIMAP), EA3064, Faculty of Medicine of Saint-Etienne, University of Lyon, France; Laboratory of Infectious agents and Hygiene, University Hospital of Saint-Etienne, France.

Objectives: This prospective study performed in the paediatric emergency department of the University Hospital of Saint-Etienne aimed to measure the impact of the 24/7 bedside use of the Veritor™ System (Becton Dickinson) on the reduction of supplementary investigations, hospital stay and antimicrobial use.

Methods: Influenzavirus A and B antigens were detected with a rapid influenza digital immunoassay (DIA) on nasopharyngeal aspirates (NPA) sampled from the children consulting at the paediatric emergency department between January and March 2016 for influenza-like illness. The same NPA was tested by immunofluorescence and/or molecular routine assays. Read More

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November 2018
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Pneumococcal carriage in vaccine-eligible children and unvaccinated infants in Lao PDR two years following the introduction of the 13-valent pneumococcal conjugate vaccine.

Vaccine 2018 Nov 27. Epub 2018 Nov 27.

Pneumococcal Research, Murdoch Children's Research Institute, Royal Children's Hospital, Flemington Road, Parkville, Australia; Department of Paediatrics, The University of Melbourne, Parkville, Australia; Centre for International Child Health, Department of Paediatrics, The University of Melbourne, Parkville, Australia.

Pneumococcal carriage is a prerequisite for disease, and underpins herd protection provided by pneumococcal conjugate vaccines (PCVs). There are few data on the impact of PCVs in lower income settings, particularly in Asia. In 2013, the Lao People's Democratic Republic (Lao PDR) introduced 13-valent PCV (PCV13) as a 3 + 0 schedule (doses at 6, 10 and 14 weeks of age) with limited catch-up vaccination. Read More

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November 2018

Comparison of tissue oxygenation achieved breathing oxygen from a demand valve with four different mask configurations.

Diving Hyperb Med 2018 Dec;48(4):209-217

Department of Kinesiology, Faculty of Medicine, Université Laval, Québec, Canada.

Introduction: High concentration normobaric oxygen (O₂) is a priority in treating divers with suspected decompression illness. The effect of different O₂ mask configurations on tissue oxygenation when breathing with a demand valve was evaluated.

Methods: Sixteen divers had tissue oxygen partial pressure (PtcO₂) measured at six limb sites. Read More

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December 2018
1 Read

Underweight, overweight, and obesity as independent risk factors for hospitalization in adults and children from influenza and other respiratory viruses.

Influenza Other Respir Viruses 2018 Dec 4. Epub 2018 Dec 4.

Leidos Biomedical Research Inc. in support of National Institute of Allergy and Infectious Diseases, Bethesda, Maryland.

Background: The relationship between obesity and risk of complications described during the 2009 influenza pandemic is poorly defined for seasonal influenza and other viral causes of influenza-like illness (ILI).

Methods: An observational cohort of hospitalized and outpatient participants with ILI was conducted in six hospitals in Mexico. Nasopharyngeal swabs were tested for influenza and other common respiratory pathogens. Read More

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December 2018

Omitting the lower neck and sparing the glottic larynx in node-negative nasopharyngeal carcinoma was safe and feasible, and improved patient-reported voice outcomes.

Clin Transl Oncol 2018 Dec 4. Epub 2018 Dec 4.

Department of Oral and Maxillofacial-Head Neck Oncology, Shanghai Ninth People's Hospital, College of Stomatology, Shanghai Jiao Tong University School of Medicine, 639 Zhizaoju Road, Shanghai, 200011, People's Republic of China.

Background: Worsening voice and speech quality was frequently reported in head-and-neck patients after radiotherapy to the neck; omitting the lower neck and sparing the glottic larynx in node-negative nasopharyngeal carcinoma (NPC) patients might be safe and feasible, and improve voice and speech outcomes.

Methods: From January 2009 to January 2013, 71 patients were analyzed. All patients received bilateral neck irradiation. Read More

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December 2018
3 Reads

A rare presentation of a paediatric sinonasal inverted papilloma.

J Surg Case Rep 2018 Nov 30;2018(11):rjy321. Epub 2018 Nov 30.

Department of Otorhinolaryngology-Head and Neck Surgery, University Hospital Southampton NHS Foundation Trust, Tremona Road, Southampton, UK.

Sinonasal inverted papilloma (IP) is a benign tumour with an extremely low incidence in children. We report the case of an 11-year-old Caucasian male presenting with recurrent right-sided epistaxis, nasal obstruction and a mass in the right nasal cavity. An initial diagnosis of a nasopharyngeal angiofibroma was considered; however, on detailed histological examination, the mass was found to be an inverted papilloma. Read More

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November 2018

The Relationship between Colonization by and Tonsillar Hypertrophy.

Can J Infect Dis Med Microbiol 2018 1;2018:5406467. Epub 2018 Nov 1.

Department of Ophthalmology, Otorhinolaryngology, Head and Neck Surgery, Ribeirao Preto Medical School, University of São Paulo, Ribeirao Preto, SP 14049-900, Brazil.

We sought to investigate the prevalence of potentially pathogenic bacteria in secretions and tonsillar tissues of children with chronic adenotonsillitis hypertrophy compared to controls. Prospective case-control study comparing patients between 2 and 12 years old who underwent adenotonsillectomy due to chronic adenotonsillar hypertrophy to children without disease. We compared detection of , , , and by real-time PCR in palatine tonsils, adenoids, and nasopharyngeal washes obtained from 37 children with and 14 without adenotonsillar hypertrophy. Read More

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November 2018
1 Read

Inhibition of autophagy by chloroquine makes chemotherapy in nasopharyngeal carcinoma more efficient.

Auris Nasus Larynx 2018 Dec 1. Epub 2018 Dec 1.

Division of Otolaryngology - Head and Neck Surgery, Graduate School of Medicine, Kanazawa University, Kanazawa, Japan. Electronic address:

Objectives: A combination of platinum-based chemotherapy and radiotherapy is the standard treatment for nasopharyngeal carcinoma (NPC). However, the efficacy of chemotherapy has reached a plateau. Many autophagy studies suggest that autophagy can either promote or suppress to cancer progression. Read More

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December 2018

Does metformin usage improve survival in head and neck squamous cell carcinoma? A population-based study.

J Otolaryngol Head Neck Surg 2018 Dec 4;47(1):74. Epub 2018 Dec 4.

Department of Otolaryngology, Head and Neck Surgery, University of Ottawa, 501 Smyth Rd, Module S - Room M2566, Box 216, Ottawa, ON, K1H 8L6, Canada.

Background: We sought to expand upon preliminary data suggesting that metformin confers a survival benefit to patients with head and neck squamous cell carcinoma (HNSCC).

Methods: A large-scale retrospective cohort study of all patients in Ontario diagnosed with squamous cancer of the larynx, hypopharynx, and nasopharynx between Dec 1st 2007 to Dec 1st 2012 was undertaken. The Institute for Clinical and Evaluative Sciences was accessed to obtain patient demographic, treatment and outcome information. Read More

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December 2018

Matrix association region/scaffold attachment region (MAR/SAR) sequence: its vital role in mediating chromosome breakages in nasopharyngeal epithelial cells via oxidative stress-induced apoptosis.

BMC Mol Biol 2018 Dec 4;19(1):15. Epub 2018 Dec 4.

Molecular Pathology Unit, Cancer Research Centre, Institute for Medical Research, Kuala Lumpur, Malaysia.

Background: Oxidative stress is known to be involved in most of the aetiological factors of nasopharyngeal carcinoma (NPC). Cells that are under oxidative stress may undergo apoptosis. We have previously demonstrated that oxidative stress-induced apoptosis could be a potential mechanism mediating chromosome breakages in nasopharyngeal epithelial cells. Read More

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December 2018

The Prognostic Significance of Neutrophil-to-Lymphocyte Ratio in Head and Neck Cancer Patients Treated with Radiotherapy.

J Clin Med 2018 Dec 3;7(12). Epub 2018 Dec 3.

Department of Radiation Oncology, Gangnam Severance Hospital, Yonsei University College of Medicine, Seoul 06273, Republic of Korea.

Background: To investigate the prognostic value of pre-treatment neutrophil/lymphocyte ratio (NLR) in patients treated with definitive radiotherapy (RT) for head and neck cancer.

Methods: We retrospectively analyzed 621 patients who received definitive RT for nasopharyngeal, oropharyngeal, hypopharyngeal, and laryngeal cancer. An NLR cut-off value of 2. Read More

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December 2018

Comparative models for human nasal infections and immunity.

Dev Comp Immunol 2018 Dec 1. Epub 2018 Dec 1.

University of New Mexico, Department of Biology, Center for Evolutionary and Theoretical Immunology (CETI), Albuquerque, New Mexico, USA.

The human olfactory system is a mucosal surface and a major portal of entry for respiratory and neurotropic pathogens into the body. Understanding how the human nasopharynx-associated lymphoid tissue (NALT) halts the progression of pathogens into the lower respiratory tract or the central nervous system is key for developing effective cures. Although traditionally mice have been used as the gold-standard model for the study of human nasal diseases, mouse models present important caveats due to major anatomical and functional differences of the human and murine olfactory system and NALT. Read More

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December 2018
2 Reads

Effects of Salivary Mg on Head and Neck Carcinoma via TRPM7.

J Dent Res 2018 Dec 4:22034518813359. Epub 2018 Dec 4.

3 Oral and Maxillofacial Surgery, Faculty of Dentistry, University of Hong Kong, Hong Kong, China.

Magnesium (Mg) has been known to play vital roles in regulating growth and various metabolic processes. In recent years, the association between Mg and tumorigenesis has raised more and more attention. However, the effects of Mg on the progression of head and neck carcinoma (HNC), as well as the mechanism behind it, remain undefined. Read More

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December 2018
3 Reads

Prehospital Airway Management in Iraq and Afghanistan: A Descriptive Analysis.

South Med J 2018 Dec;111(12):707-713

From the US Army Institute of Surgical Research, Joint Base San Antonio-Fort Sam Houston, Texas, the 59th Medical Wing, Joint Base San Antonio-Lackland Air Force Base, Texas, the San Antonio Military Medical Center, Joint Base San Antonio-Fort Sam Houston, Texas, the Madigan Army Medical Center, Joint Base Lewis McChord, Washington, and the Army Medical Department Center and School Health Readiness Center of Excellence, Joint Base San Antonio-Fort Sam Houston, Texas.

Objectives: Airway failures are the second leading cause of potentially preventable death on the battlefield. Improvements in airway management depend on identifying current challenges. We sought to build on previously reported data on prehospital, combat airway management. Read More

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December 2018
2 Reads

Amide proton transfer MRI detects early changes in nasopharyngeal carcinoma: providing a potential imaging marker for treatment response.

Eur Arch Otorhinolaryngol 2018 Dec 3. Epub 2018 Dec 3.

Medical Physics and Research Department, Hong Kong Sanatorium & Hospital, Happy Valley, Hong Kong S.A.R., China.

Purpose: To determine if treatment of nasopharyngeal carcinoma (NPC) induces early changes in amide proton transfer-weighted (APTw) magnetic resonance imaging (MRI), and to perform a preliminary evaluation of APTw imaging in response assessment.

Methods: Sixteen patients with NPC planned for treatment with radiotherapy and/or chemotherapy underwent APTw imaging of the primary tumour pre-treatment and 2-week intra-treatment. Difference in pre- and intra-treatment APT mean (APT) was compared using the Wilcoxon signed rank test. Read More

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December 2018
3 Reads

Subdural empyema complicated with intracranial hemorrhage in a postradiotherapy nasopharyngeal carcinoma patient: A case report and review of literature.

World J Clin Cases 2018 Nov;6(14):825-829

Department of Neurosurgery, First Affiliated Hospital of Shantou University Medical College, Shantou 515041, Guangdong Province, China.

The prevalence of nasopharyngeal carcinoma (NPC) is higher in southern China, Hong Kong, and Taiwan than in other areas in the world. Radiotherapy is an important part of treatment for NPC patients, especially those with stage III/IV disease. Subdural empyema is a rare but life-threatening complication in postradiotherapy NPC patients which should be paid more attention. Read More

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November 2018

High HLA-F Expression Is a Poor Prognosis Factor in Patients with Nasopharyngeal Carcinoma.

Anal Cell Pathol (Amst) 2018 30;2018:7691704. Epub 2018 Oct 30.

The Department of Radiotherapy, Taizhou Central Hospital (Taizhou University Hospital), Taizhou, Zhejiang, China.

Background And Aims: In patients with nasopharyngeal carcinoma (NPC), local treatment failure and distant metastasis contribute largely to poor outcomes. The nasopharynx is an important lymphoid tissue, and NPC tumourigenesis and development are partly attributed to immune system disorders. Human leukocyte antigen F (HLA-F) has shown a close correlation with NPC in many genome-wide association studies (GWASs). Read More

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October 2018

Prognostic Significance of Pretreatment Apolipoprotein A-I as a Noninvasive Biomarker in Cancer Survivors: A Meta-Analysis.

Dis Markers 2018 30;2018:1034037. Epub 2018 Oct 30.

Department of General Surgery, The First People's Hospital of Neijiang, Neijiang, 641000 Sichuan Province, China.

Background: Numerous studies have reported the prognostic significance of serum apolipoprotein A-I (ApoA-I) in various cancers, but the results have been inconsistent. The current meta-analysis was performed to investigate the association between ApoA-I level and prognosis in human malignancies.

Methods: A literature search was performed using the electronic platforms of the PubMed, Cochrane Library, Web of Science, Embase, Wanfang, and China National Knowledge Infrastructure (CNKI) databases to obtain eligible articles published up to May 20, 2018. Read More

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October 2018

Decreased Pituitary Height and Stunted Linear Growth After Radiotherapy in Survivors of Childhood Nasopharyngeal Carcinoma Cases.

Front Endocrinol (Lausanne) 2018 19;9:643. Epub 2018 Nov 19.

State Key Laboratory of Oncology in South China, Guangdong Key Laboratory of Nasopharyngeal Carcinoma Diagnosis and Therapy, Department of Cancer Prevention, Collaborative Innovation Center for Cancer Medicine, Sun Yat-sen University Cancer Center, Guangzhou, China.

To examine the morphological changes of the pituitary glands and linear growth of childhood nasopharyngeal carcinoma (NPC) cases who accepted radiotherapy. A total of 90 children (i.e. Read More

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November 2018
2 Reads

Clinical evaluation of vascular normalization induced by recombinant human endostatin in nasopharyngeal carcinoma via dynamic contrast-enhanced ultrasonography.

Onco Targets Ther 2018 8;11:7909-7917. Epub 2018 Nov 8.

Department of Radiation Oncology, The First Affiliated Hospital of Guangxi Medical University, Guangxi Tumor Radiation Therapy Clinical Medical Research Center, Guangxi, People's Republic of China,

Background: The present study confirmed the presence and exact range of "vascular normalization window" induced by recombinant human endostatin (RHES) in patients with nasopharyngeal carcinoma (NPC) by analyzing the variation of dynamic contrast-enhanced ultrasonography (DCE-US) quantitative parameters. Also, the clinical application of DCE-US in the evaluation of vascular normalization was assessed.

Materials And Methods: A total of 30 previously untreated patients with stage III-IVA NPC were enrolled in the present study and were randomly but equally divided into RHES (endostar [ES]) and normal saline (NS) groups. Read More

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November 2018
1 Read

Investigating the photo-thermo-radiosensitization effects of folate-conjugated gold nanorods on KB nasopharyngeal carcinoma cells.

Photodiagnosis Photodyn Ther 2018 Dec 27;24:324-331. Epub 2018 Oct 27.

Medical Physics Department, School of Medicine, Iran University of Medical Sciences (IUMS), Tehran, Iran. Electronic address:

In this article, we report a targeted cancer treatment strategy using nano-photo-thermal therapy (NPTT) and radiotherapy (RT) methods. Gold nanorods (AuNRs) without and with folic acid (FA) conjugation were firstly synthesized and then characterized. Cytotoxicity of various methods; NPTT (nanoparticles; 808 nm laser; 2 W/cm) or RT (6 MV X-ray; 2 Gy) or combination of NPTT and RT; was separately investigated on KB nasopharyngeal carcinoma cells. Read More

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December 2018
1 Read

Data Set for the Reporting of Carcinomas of the Nasopharynx and Oropharynx: Explanations and Recommendations of the Guidelines From the International Collaboration on Cancer Reporting.

Arch Pathol Lab Med 2018 Nov 30. Epub 2018 Nov 30.

From the Departments of Otolaryngology, and Pathology, Microbiology, and Immunology, Vanderbilt University Medical Center, Nashville, Tennessee (Dr Lewis); the Department of Otorhinolaryngology, Cleveland Clinic, Cleveland, Ohio (Dr Adelstein); the Institute of Pathology, Friedrich-Alexander University Erlangen-Nuremberg, University Hospital, Erlangen, Germany (Dr Agaimy); the Department of Pathology, Cleveland Clinic Florida, Weston (Dr Carlson); the Department of Pathology, Massachusetts General Hospital, Boston (Dr Faquin); the Department of Cellular Pathology, University of Liverpool, Liverpool, United Kingdom (Dr Helliwell); the Department of Oral & Maxillofacial Pathology, University of the Western Cape & Tygerberg Laboratories, Cape Town, South Africa (Dr Hille); the Department of Pathology, Vancouver General Hospital, and the Department of Pathology and Laboratory Medicine, University of British Columbia, Vancouver, Canada (Dr Ng); the Department of Pathology, Queen Mary Hospital, Hong Kong (Dr Nicholls); the Radiation Medicine Program, Princess Margaret Hospital, Toronto, Ontario, Canada (Dr O'Sullivan); and the Department of Pathology, Woodland Hills Medical Center, Woodland Hills, California (Dr Thompson).

The International Collaboration on Cancer Reporting was established to internationally unify and standardize the pathologic reporting of cancers based on collected evidence, as well as to allow systematic data collection across institutions and countries to guide cancer care in the future. An expert panel was convened to identify the minimum data set of elements that should be included in cancer reporting from tumors of the nasopharynx and oropharynx. Specifically, there has been a significant change in practice as a result of identifying oncogenic viruses, including human papillomavirus and Epstein-Barr virus, because they preferentially affect the oropharynx and nasopharynx, respectively. Read More

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November 2018

Data Set for the Reporting of Nodal Excisions and Neck Dissection Specimens for Head and Neck Tumors: Explanations and Recommendations of the Guidelines From the International Collaboration on Cancer Reporting (ICCR).

Arch Pathol Lab Med 2018 Nov 30. Epub 2018 Nov 30.

From the Department of Pathology, Dalhousie University and Queen Elizabeth II Health Sciences Centre, Halifax, Nova Scotia, Canada (Dr Bullock); the Department of Radiation Oncology, Winship Cancer Institute, Emory University, Atlanta, Georgia (Dr Beitler); the Pathology and Laboratory Medicine Institute, Cleveland Clinic, Weston, Florida (Dr Carlson); the Instituto de Anatomia Patológica, Faculdade de Medicina, Universidade de Lisboa, Lisboa, Portugal (Dr Fonseca); the Department of Pathology, University of Arkansas for Medical Sciences, Little Rock (Dr Hunt); the Department of Pathology, Memorial Sloan Kettering Cancer Center, New York, New York (Dr Katabi); the Department of Cellular Pathology, Newcastle University, Newcastle upon Tyne, United Kingdom (Dr Sloan); the Department of Surgery, Division of Otolaryngology-Head and Neck Surgery, Dalhousie University, Halifax, Nova Scotia, Canada (Dr Taylor); the Department of Pathology, The University of Texas MD Anderson Cancer Center, Houston (Dr Williams); and the Department of Pathology, Southern California Permanente Medical Group, Woodland Hills Medical Center, Woodland Hills, California (Dr Thompson).

Standardized, synoptic pathologic reporting for tumors greatly improves communication among clinicians, patients, and researchers, supporting prognostication and comparison about patient outcomes across institutions and countries. The International Collaboration on Cancer Reporting is a nonprofit organization whose mission is to develop evidence-based, universally available surgical pathology reporting data sets. Within the head and neck region, lymph node excisions and neck dissections are frequently performed as part of the management of head and neck cancers arising from the mucosal sites (sinonasal tract, nasopharynx, oropharynx, hypopharynx, oral cavity, and larynx), along with bone tumors, skin cancers, melanomas, and other tumor categories. Read More

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November 2018

Long noncoding RNA UCA1 promotes the proliferation, invasion, and migration of nasopharyngeal carcinoma cells via modulation of miR-145.

Onco Targets Ther 2018 25;11:7483-7492. Epub 2018 Oct 25.

Department of Radiotherapy, Jiangsu Cancer Hospital & Jiangsu Institute of Cancer Research & The Affiliated Cancer Hospital of Nanjing Medical University, Nanjing, Jiangsu, China,

Background: Nasopharyngeal carcinoma (NPC) is a common malignant tumor characterized by highly malignant local invasion and distant metastasis. Recently, increasing attention has been paid to long noncoding RNAs (lncRNAs), which play significant roles in tumorigenesis and progression. However, little is known about the potential role of the lncRNA urothelial carcinoma-associated 1 (UCA1) in NPC cell invasion and migration. Read More

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October 2018

The effect of passive smoking on bacterial colonisation of the upper airways and selected laboratory parameters in children.

Acta Otorhinolaryngol Ital 2018 Oct;38(5):431-438

Department of Paediatrics, Comenius University in Bratislava, Jessenius Faculty of Medicine in Martin, University Hospital, Martin, Slovakia.

Exposure to tobacco smoke is associated with a higher risk of respiratory tract diseases. The aim of this study was to determine the influence of passive smoking on selected characteristics of children with adenoid hypertrophy. Sixty-one children with adenoid hypertrophy were enrolled in the prospective study. Read More

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October 2018

Urine Xpert MTB/RIF for the diagnosis of childhood tuberculosis.

Int J Infect Dis 2018 Nov 26. Epub 2018 Nov 26.

University of California Los Angeles, California, USA.

Introduction: Xpert MTB/RIF is recommended for the simultaneous detection of tuberculosis (TB) and rifampicin resistance directly from sputum specimens. Since young children cannot always expectorate, we assessed urine as a possible specimen source to diagnose TB in children using Xpert MTB/RIF.

Methods: During a field study to enhance childhood TB identification, spot urine samples were prospectively collected from consecutive ambulatory children aged 0 to 14 years presenting with presumptive pulmonary TB in community health centers. Read More

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November 2018
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Placenta specific 8 gene induces epithelial-mesenchymal transition of nasopharyngeal carcinoma cells via the TGF-β/Smad pathway.

Exp Cell Res 2018 Nov 26. Epub 2018 Nov 26.

Department of Otolaryngology-Head and Neck Surgery, Central Laboratory, Renmin Hospital of Wuhan University, 238 Jie-Fang Road, Wuhan, Hubei 430060, PR China; Research Institute of Otolaryngology-Head and Neck Surgery, Renmin Hospital of Wuhan University, 238 Jie-Fang Road, Wuhan, Hubei 430060, PR China. Electronic address:

The present study aimed to investigate the effects and mechanisms of PLAC8 on the epithelial-mesenchymal transition (EMT) of Nasopharyngeal carcinoma (NPC). The expression of PLAC8 in NPC and nasopharyngitis (NPG) tissues from 150 patients was determined using immunohistochemistry. The levels of PLAC8 in five NPC cell lines and nasopharyngeal permanent epithelial cell line were measured using western blotting. Read More

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November 2018

High Density Bacterial Nasal Carriage in Children is Transient and Associated With Respiratory Viral Infections - Implications for Transmission Dynamics.

Pediatr Infect Dis J 2018 Nov 27. Epub 2018 Nov 27.

Background: This longitudinal study describes the associations between respiratory viral infections, rhinitis and the prevalence and density of the common nasopharyngeal bacterial colonisers, S. pneumoniae, M. catarrhalis, H. Read More

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November 2018