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J Endod 2021 Apr 24. Epub 2021 Apr 24.

Department of Endodontics, Israel Defense Forces Medical Corps, Tel Hashomer, Israel.

Nasopalatine duct cysts (NPDCs) and other nonodontogenic lesions of the oral cavity may mimic odontogenic pathoses. We present a case of a 22-year-old man with a history of dental trauma and a lesion displaying the typical clinical and radiographic signs of a chronic apical abscess- a buccal sinus tract that was traced to a radiolucent area in the periapex of a maxillary central incisor. A comprehensive diagnostic process that included a cone-beam computed tomographic scan and a histopathologic examination of the lesion after complete enucleation led to the final diagnosis of an infected NPDC. Read More

Orv Hetil 2021 Mar;162(12):458-467

Szegedi Tudományegyetem, Fogorvostudományi Kar, Fogpótlástani Tanszék, Szeged.

Összefoglaló. Bevezetés: Az állcsonti cysták helytálló diagnosztikája a klinikai, radiológiai és patológiai leletek együttes értékelésével lehetséges. Korábbi munkánk során többször tapasztaltuk a klinikoradiopatológiai kommunikáció és korreláció hiányát, és ez olykor inadekvát diagnózisok felállításához vezetett. Read More

Indian J Radiol Imaging 2020 Jul-Sep;30(3):340-343. Epub 2020 Oct 15.

Department of Oral Pathology and Microbiology, Subharti Dental College, Swami Vivekanand Subharti University, Meerut, Uttar Pradesh, India.

Spectrum of lesions that occur in the jaws have a cyst-like radiographic appearance. These lesions may be odontogenic or non-odontogenic and are often difficult to differentiate them on the basis of their clinical, radiographic features alone. Among odontogenic lesions without mineralization, ameloblastomas, odontogenic keratocysts, and dentigerous cysts can all appear as well-defined, unilocular, well-corticated, lucent lesions that can mimic with non-odontogenic cysts and tumors like nasopalatine duct cyst, aneurysmal bone cyst, central giant cell granuloma, hemangioma and so on. Read More

J Endod 2020 Aug 15;46(8):1155-1162. Epub 2020 May 15.

Department of Endodontics and Dental Research, Iguaçu University (UNIG), Nova Iguaçu, RJ, Brazil; Department of Endodontics, Faculty of Dentistry, Grande Rio University (UNIGRANRIO), Rio de Janeiro, RJ, Brazil.

This article reports on the management of a large median symmetrical lesion of the anterior palate, which was clinically and radiographically diagnosed as an infected nasopalatine duct cyst. However, histopathology demonstrated it to be a radicular cyst of endodontic origin. Read More

Dent Clin North Am 2020 01 17;64(1):63-85. Epub 2019 Oct 17.

Oral & Maxillofacial Surgery, Lincoln Medical & Mental Health Center, 234 East 149th Street, Bronx, NY 10451, USA.

This article focuses on describing nonodontogenic cysts of the oral and maxillofacial region. The lesions described include nasopalatine duct canal cyst, nasolabial cyst, traumatic bone cyst, Stafne bone cyst, aneurysmal bone cyst, focal osteoporotic bone marrow defect, dermoid cyst, epidermoid cyst, pilar cyst, and sebaceous cyst. The intent of this article is to make general dentists aware and knowledgeable of the nonodontogenic cysts they may encounter in everyday practice, so they can adequately manage or make an appropriate referral to improve treatment outcomes and reduce patient morbidity. Read More

Dental Press J Orthod 2019 Sep 5;24(4):21-32. Epub 2019 Sep 5.

Universidade de São Paulo, Faculdade de Odontologia de Ribeirão Preto, Programa de Pós-Graduação em Odontopediatria (Ribeirão Preto/SP, Brazil).

Knife-edge or blunt root resorptions characterize ameloblastomas and are pathognomonic for this tumor, because they differentiate ameloblastomas from simple bone cysts, odontogenic keratocysts and nasopalatine duct cysts, which do not lead to resorption of involved teeth. Despite the very high frequency and importance of these characteristics for a differential diagnosis, a microscopic examination should also be conducted before defining the diagnosis and the treatment plan for these cases. This paper describes a six-step hypothesis to explain the mechanism by which ameloblastomas promote the characteristic root resorptions found in association with these benign epithelial tumors, which have a fibrous capsule formed by islands and epithelial cords that mimic the dental lamina, invade neighboring tissues and release mediators (IL-1, EGF) of tooth and root resorption. Read More

Chin J Dent Res 2019;22(1):51-56

Objective: To investigate the usefulness of diffusion-weighted magnetic resonance imaging (DWI) in odontogenic keratocysts, especially apparent diffusion coefficient (ADC) maps for the characterisation of normal structures and cystic lesions in the jaw.

Methods: Sixteen patients who underwent magnetic resonance imaging (MRI) for the diagnosis of a cystic lesion in the jaw were included in this prospective study. DWI was performed on a 1. Read More

Oral Radiol 2018 09 4;34(3):224-228. Epub 2017 Sep 4.

Department of Radiology, The Nippon Dental University Niigata Hospital, 1-8 Hamaura-cho, Chuo-ku, Niigata, Niigata, 951-8580, Japan.

Objectives: The aim of this study was to investigate the usefulness of diffusion-weighted magnetic resonance imaging (DWI) in oral and maxillofacial lesions, especially the utility of apparent diffusion coefficient (ADC) maps for differential diagnosis of these lesions.

Methods: Fifty-seven patients who underwent magnetic resonance imaging for diagnosis of oral and maxillofacial lesions were included in this prospective study. DWI was performed on a 1. Read More

J Oral Maxillofac Pathol 2018 May-Aug;22(2):286

Department of Oral and Maxillofacial Surgery, Rajarajeswari Dental College, Bengaluru, Karnataka, India.

Median palatal cyst is rare nonodontogenic lesion as it represents only 7.14% of all jaw cysts. Also called mid palatal cyst has raised controversy about pathogenesis of such fissural cysts. Read More

J Craniomaxillofac Surg 2018 Feb 2;46(2):264-268. Epub 2017 Dec 2.

Department of Dentistry, Postgraduate Program in Oral Pathology, Federal University of Rio Grande do Norte, Natal, RN, Brazil. Electronic address:

Purpose: To evaluate the clinical and histopathological features of nasopalatine duct cysts (NDCs) stored in the archives of a referred Oral Pathology Service over a 47-year-period, and to review current concepts about these cysts.

Material And Methods: All NDCs were reviewed, and clinical data were obtained from the patient records. Thirty cases were re-evaluated microscopically by 2 oral pathologists. Read More

J Dent (Tehran) 2017 May;14(3):132-137

Epidemiologist, Dental Research Center, Dentistry Research Institute, Tehran University of Medical Sciences, Tehran, Iran.

Objectives: The frequency of non-odontogenic lesions of the jawbones is lower than that of odontogenic lesions; however, study of the epidemiologic data of these lesions is required for health care programs. This study aimed to assess the relative frequency and demographic profile of non-odontogenic jaw lesions in an Iranian population over a 30-year period.

Materials And Methods: This archive review was performed using demographic and biopsy information of all patients with non-odontogenic lesions of the jawbones submitted to the Oral Pathology Department of Dental School of Tehran University of Medical Sciences from 1984 to 2014. Read More

Niger J Clin Pract 2017 07;20(7):879-883

Department of Oral and Maxillofacial Surgery, Faculty of Dentistry, Ataturk University, Erzurum, Turkey.

Purpose: The aim of this study was to determine the age, gender, and sites of different types of odontogenic cysts (OCs) and non-OCs (nOCs) (seen in eastern Anatolian population in Turkey.

Materials And Methods: The following data were collected from the clinical records and histopathology reports of the Department of Oral and Maxillofacial Surgery and the Department of Oral Pathology, Ataturk University, Turkey, during a period of 10 years. They were analyzed descriptively in terms of incidence, age, sex, cyst type, and site. Read More

J Investig Clin Dent 2017 Nov 4;8(4). Epub 2017 Jan 4.

Department of Pathology and Laboratory Medicine, University of Western Ontario, London, Ontario, Canada.

Aim: The aim of the present study was to profile the expression of human kallikrein (KLK)-related peptidases (KLK) in odontogenic lesions.

Methods: Paraffin-embedded, formalin-fixed, non-odontogenic (control) and odontogenic lesions were stained for KLK using a standard immunohistochemical technique. The intensity and proportion of epithelial cells stained was scored. Read More

J Pharm Bioallied Sci 2016 Oct;8(Suppl 1):S185-S188

Department of OMFS, Ragas Dental College and Hospital, Chennai, Tamil Nadu, India.

Nasopalatine duct cyst is the nonodontogenic developmental cyst, frequently occurring in the midline of the anterior maxillary region. The clinical presentation of the cyst is often varied and presents a diagnostic difficulty and frequently misdiagnosed as developmental or inflammatory odontogenic cystic lesion. This paper represents a large infected nasopalatine duct cyst presenting with complete destruction of anterior palate and pyriform rim. Read More

N Am J Med Sci 2016 Jan;8(1):13-6

Department of Oral Medicine and Diagnostic Sciences, Al-Farabi Colleges, Riyadh, Saudi Arabia.

Background: Dental implantation is considered as one of the most widely employed procedures in dental practice. Nasopalatine duct cyst (NPDC) is one of the most common developmental cysts in the oral cavity that develops from the proliferation of embryological epithelial remnants of nasopalatine duct.

Aim: The aim of this study was to highlight the development of NPDC after the placement of dental implants. Read More

Gen Dent 2016 Jan-Feb;64(1):63-6

Lesions of nonendodontic origin, such as nasopalatine or globulomaxillary cysts, may mimic periapical radiolucencies associated with pulpal pathosis, and incorrect diagnosis may lead to unnecessary endodontic treatment. Horizontal root fractures most commonly affect the maxillary central and lateral incisors. Prognosis depends largely on the level of fracture; fractures in the apical third have the best prognosis, and those in the cervical third have the worst. Read More

Oral Maxillofac Surg Clin North Am 2016 Feb;28(1):31-44

Department of Oral and Maxillofacial Surgery, Harborview Medical Center, School of Dentistry, University of Washington, 4West Clinic, 325 9th Avenue, Seattle, WA 98104, USA. Electronic address:

Nonodontogenic cysts within the jaws are not a common presentation in the pediatric population. Cysts within the pediatric population tend to be developmental and odontogenic in nature. Although nonodontogenic cysts of the jaws are relatively uncommon, it is imperative the clinician understand their clinical behavior and management because failure to do so can result in increased patient morbidity. Read More

J Formos Med Assoc 2015 Nov 29;114(11):1142-4. Epub 2015 Aug 29.

Graduate Institute of Clinical Dentistry, School of Dentistry, National Taiwan University, Taipei, Taiwan; Department of Dentistry, National Taiwan University Hospital, College of Medicine, National Taiwan University, Taipei, Taiwan; Graduate Institute of Oral Biology, School of Dentistry, National Taiwan University, Taipei, Taiwan. Electronic address:

Clin Oral Investig 2016 Apr 7;20(3):553-61. Epub 2015 Aug 7.

Department of Oral Surgery and Stomatology, School of Dental Medicine, University of Bern, Freiburgstrasse 7, 3010, Bern, Switzerland.

Objectives: Maxillary incisors (MI) are often affected by dentoalveolar injury resulting in tooth devitalization and apical periodontitis. The aim of the present study was to analyze any association between a history of dentoalveolar injury and the shape and size of the nasopalatine canal (NC) using cone beam computed tomography (CBCT).

Material And Methods: Patients were allocated to the trauma group if they had a history of dentoalveolar injury and a root filling in at least one MI and/or one missing MI. Read More

J Clin Diagn Res 2015 May 1;9(5):ZD21-2. Epub 2015 May 1.

Assistant Professor, Department of Prosthetic Dentistry, Penang International Dental College , Malaysia .

Nasopalatine duct cyst ( NPDC) is described as most common non-odontogenic developmental cyst of the jaws. Despite being common, its clinical and radiographic presentation could be varied and it can sometimes be a diagnostic challenge. This paper presents an unusual case of an infected NPDC associated with an impacted inverted mesiodens and a history of trauma that misled the clinical diagnosis. Read More

Clin Pract 2015 Jan 5;5(1):748. Epub 2015 Feb 5.

Department of Otolaryngology-Head and Neck Surgery, Tohoku University Graduate School of Medicine , Miyagi, Japan.

Nasopalatine duct cysts are the most common non-odontogenic cysts in the maxilla, and are conventionally treated through a sublabial or palatine approach. Recently, the endoscopic approach has been used, but experience is extremely limited. We treated a 29-year-old male with nasopalatine duct cyst by endoscopic marsupialization, but paresthesia of the incisor region occurred after surgery. Read More

Clin Oral Investig 2015 Sep 13;19(7):1611-8. Epub 2015 Jan 13.

Department of Oral Surgery and Stomatology, School of Dental Medicine, University of Bern, Freiburgstrasse 7, 3010, Bern, Switzerland.

Objectives: The aims of the study were to use cone beam computed tomography (CBCT) images of nasopalatine duct cysts (NPDC) and to calculate the diameter, surface area, and 3D-volume using a custom-made software program. Furthermore, any associations of dimensions of NPDC with age, gender, presence/absence of maxillary incisors/canines (MI/MC), endodontic treatment of MI/MC, presenting symptoms, and postoperative complications were evaluated.

Material And Methods: The study comprised 40 patients with a histopathologically confirmed NPDC. Read More

Braz J Otorhinolaryngol 2014 Sep-Oct;80(5):448-50. Epub 2014 Jul 4.

Odontology Program, Universidade Estadual da Paraíba (UEPB), João Pessoa, PB, Brazil.

J Oral Implantol 2014 Apr;40(2):189-95

British Society of Oral Implantology Southport, Merseyside, UK.

The dental literature reports frequently on both the success and survival of dental implants, whereby the focus remains on the biological response of hard and soft tissue to the implants. The predication and anticipation of adverse implant events can then lead to the preemption of implant loss. However, biological situations can arise that are outside the control of the clinician. Read More

BMJ Case Rep 2014 Mar 18;2014. Epub 2014 Mar 18.

Department of Oral Pathology and Microbiology, Manipal College of Dental Sciences, Manipal, Karnataka, India.

Endodontic diagnosis is challenging and depends on the organisation of information from the patient history, clinical examination and analysis of the pulp, radiographic and histopathological assessment. A 35-year-old man was endodontically treated for radiolucency in relation to the roots of maxillary central incisors as it was a provisionally diagnosed case of radicular cyst. Since the palatal swelling persisted, the lesion was re-evaluated using relevant diagnostic aids and a diagnosis of nasopalatine duct cyst (NPDC) was made, which was missed during the initial assessment. Read More

J Craniofac Surg 2014 ;25(2):e155-6

From the *Department of Otorhinolaryngology, College of Medicine, and †Department of Oral and Maxillofacial Surgery, College of Dentistry, Yonsei University, Seoul, Korea.

Nasopalatine duct cyst is one of the most common cysts among the nonodontogenic cysts in the maxillofacial area. This lesion usually does not show specific symptoms except for pressure from large cysts or infectious symptoms. Surgical removal including the epithelial lining is considered the treatment of choice. Read More

J Maxillofac Oral Surg 2013 Mar 29;12(1):100-4. Epub 2011 Mar 29.

Department of Oral and Maxillofacial Surgery, School of Oral Health Sciences, University of Limpopo, Pietersburg, South Africa.

A case of an unusually large expansile nasopalatine duct cyst (NPDC) causing extensive destruction of the hard palate with involvement of the nasal cavity, perforation of the alveolar process and mucosa of the maxilla by pressure of the maxillary anterior teeth is being presented. Read More

Indian J Otolaryngol Head Neck Surg 2013 Dec 11;65(4):385-8. Epub 2011 Apr 11.

Department of Oral & Maxillofacial Pathology, SVS Institute of Dental Sciences, Mahabubnagar, Hyderabad, Andhra Pradesh India.

The nasopalatine duct cyst is the most common non-odontogenic developmental cysts. Nasopalatine duct cyst also termed as incisive canal cyst, arises from embryologic remnants of nasopalatine duct. Most of these cysts develop in the midline of anterior maxilla near the incisive foramen. Read More

J Craniofac Surg 2014 Jan;25(1):e92-4

From the Departments of *Oral and Maxillofacial Surgery and †OMDR, Bharati Vidyapeeth University Dental College and Hospital, Katraj Pune, India.

Nasopalatine duct cysts (NPDCs) are the most common nonodontogenic cyst of the jaw, with a reported prevalence of between 1% and 11.6% of all jaw cysts.1 It is believed to arise from epithelial remnants of the nasopalatine duct, the communication between the nasal cavity and anterior maxilla in the developing fetus. Read More

J Endod 2014 Jan 5;40(1):16-27. Epub 2013 Nov 5.

João de Barros Barreto University Hospital, Belém, Pará, Brazil. Electronic address:

Introduction: This study aimed to analyze cases referred from a reference service in oral pathology that were initially misdiagnosed as periapical lesions of endodontic origin and to perform a review of the literature regarding lesions located in the apical area of teeth with a nonendodontic source.

Methods: A survey was made of clinical cases derived from the service of oral pathology from 2002 to 2012. The pertinent literature was also reviewed using ScienceDirect and PubMed databases. Read More