Search Our Scientific Publications & Authors

J Surg Res 2019 Jan 18;233:408-412. Epub 2018 Sep 18.

Division of Surgery, Trauma and Surgical Critical Care, Dewitt-Daughtry Family Department of Surgery, University of Miami Miller School of Medicine and Ryder Trauma Center, Miami, Florida.

Background: Gastrografin (GG)-based nonoperative approach is both diagnostic and therapeutic for partial small bowel obstruction (SBO). Absence of X-ray evidence of GG in the colon after 8 h is predictive of the need for operation, and a recent trial used 48 h to prompt operation. We hypothesize that a significant number of patients receiving the GG challenge require >48 h before an effect is seen. Read More

Braz J Cardiovasc Surg 2018 Sep-Oct;33(5):448-453

Department of Anesthesiology, Shiraz University of Medical Sciences, Shiraz, Iran.

Objective: Cardiac arrhythmias are a common challenge following open-heart surgeries. Hypomagnesemia is believed to be correlated with this condition. Prophylactic intravenous magnesium supplementation has been practiced for a long time in patients undergoing CABG. Read More

J Pregnancy 2018 30;2018:5378502. Epub 2018 Oct 30.

Department of Obstetrics and Gynaecology, University Medical Centers Amsterdam, University of Amsterdam, Amsterdam, Netherlands.

Introduction: Hyperemesis gravidarum (HG) medical therapies are currently of limited effect, which creates a larger role for patient preferences in the way HG care is arranged. This is the first study using in-depth interviews to investigate patients' preferences and experiences of HG treatment.

Materials And Methods: We conducted individual in-depth interviews among women who had been hospitalized for HG in North Holland at least once in the past 4 years. Read More

ANZ J Surg 2018 Nov 29. Epub 2018 Nov 29.

Department of Surgery, Léon Bérard Cancer Center, Lyon, France.

Background: Sympathetic denervation of the antropyloric area combined with relative devascularization from division of the right gastric vessels (RGV) during pancreaticoduodenectomy (PD) could predispose to delayed gastric emptying (DGE). Therefore, some authors advocated for RGV preservation (RGVP), where feasibility and utility for the prevention of post-operative DGE have never been investigated.

Methods: From 2011 to 2014, patients who underwent classic Whipple PD (CWPD, n = 34), standard pylorus-preserving PD (PPPD, n = 44) or PPPD with RGVP (n = 22) were retrospectively analysed. Read More

Laryngoscope 2018 Nov 28. Epub 2018 Nov 28.

Department of Otolaryngology, Division of Head and Neck Surgery, Stanford University School of Medicine, Palo Alto, California, U.S.A.

Objectives/hypothesis: Based on current guidelines, surgical and nonsurgical therapies are viable frontline treatment for patients with locoregional oropharyngeal carcinoma (OPC). We sought to compare financial parameters between chemoradiation and transoral robotic surgery (TORS) in this patient population.

Study Design: Case-control study. Read More

Pediatr Blood Cancer 2018 Nov 28:e27561. Epub 2018 Nov 28.

Department of Paediatric Neurology, Erasmus MC Sophia Children's Hospital, University Medical Centre, Rotterdam, the Netherlands.

Background: The mean overall survival rate of children with diffuse intrinsic pontine glioma (DIPG) is 9-11 months, with current standard treatment with fractionated radiotherapy and adjuvant chemotherapy. So far, novel therapeutic strategies have not yet resulted in significantly better survival. The main source of energy for glioblastoma cells is glucose. Read More

JGH Open 2017 Nov 31;1(3):92-97. Epub 2017 Oct 31.

Liver Injury and Cancer Centenary Research Institute Sydney New South Wales Australia.

Background And Aim: Alterations in nutrient metabolism, nutritional requirements, and reduced dietary intakes are common in chronic liver disease (CLD). These result in malnutrition, sarcopenia, and exacerbate progression to decompensation and ascites. We aimed to investigate the effects of continuous tube feeding (TF) on nutritional status and levels of ascites in malnourished individuals with decompensated cirrhosis. Read More

Int J Surg Case Rep 2018 Nov 16;53:390-393. Epub 2018 Nov 16.

Department of Surgery, MedStar Washington Hospital Center, Washington, DC, USA.

Background: Patients with gastrointestinal or gynecologic malignancy may show disease progression within the abdomen and pelvis causing bowel obstruction in the absence of clinical evidence of disease outside of the peritoneal space. Bowel obstruction eventually results and has a profound effect on quality of life eventually leading to the demise of these patients.

Methods: In order to improve the quality of life and combat the requirement for a nasogastric tube, a combination of total parenteral nutrition (TPN) to allow adequate caloric intake plus cervical esophagostomy to drain intestinal secretions was utilized as a palliative treatment long-term for patients with malignancy-associated bowel obstruction. Read More

BMC Nurs 2018 16;17:46. Epub 2018 Nov 16.

1KEMRI-Wellcome Trust Research Programme, Nairobi, Kenya.

Background: Sharing tasks with lower cadre workers may help ease the burden of work on the constrained nursing workforce in low- and middle-income countries but the quality and safety issues associated with shifting tasks are rarely critically evaluated. This research explored this gap using a Human Factors and Ergonomics (HFE) method as a novel approach to address this gap and inform task sharing policies in neonatal care settings in Kenya.

Methods: We used Hierarchical Task Analysis (HTA) and the Systematic Human Error Reduction and Prediction Approach (SHERPA) to analyse and identify the nature and significance of potential errors of nasogastric tube (NGT) feeding in a neonatal setting and to gain a preliminary understanding of informal task sharing. Read More

J Oral Maxillofac Surg 2018 Oct 25. Epub 2018 Oct 25.

Chief Professor, Department of Dentistry, Oral and Maxillofacial Plastic and Reconstructive Surgery, Faculty of Medicine, Yamagata University, Iida-nishi, Japan.

Purpose: The aim of this retrospective study was to compare the effectiveness of nasogastric tube (NGT) feeding of a semisolid diet versus a liquid diet after orthognathic surgery.

Patients And Methods: The orthognathic surgery patients were relatively young and generally healthy, without severe medical disease. Of the patients, 26 received liquid feeding (liquid diet group [LG], with an administration rate of 100 mL/hour), 30 received semisolid feeding at a high administration rate (semisolid diet-rapid administration group [SSRAG], 200 to 500 mL/hour), and 33 received semisolid feeding at a slower rate (semisolid diet-slow administration group [SSSAG], 100 mL/hour). Read More

Arch Argent Pediatr 2018 Dec;116(6):402-408

Hospital Gregorio Marañón, Madrid, España.

Objetive: To establish the effectiveness of an educational intervention to improve nurses' knowledge on pediatric nasogastric intubation.

Methods: Multicenter, quasi-experimental, pre- and post-test study using a theoretical educational intervention based on bibliographic evidence and assessment of its effectiveness after 4 months.

Results: Delivered questionnaires: 1019. Read More

Int Immunopharmacol 2018 Nov 16;66:146-153. Epub 2018 Nov 16.

Respiratory and Critical Care Department, The First Hospital of China Medical University, Shenyang, Liaoning, China. Electronic address:

The p38 MAPK signaling pathway plays a key role in lung inflammation and the development of acute lung injury (ALI). We previously reported that the phenolic compound procyanidin B1 inhibits inflammation by suppressing the p38 MAPK signaling pathway. Here, we asked whether the monomer of procyanidin B1, epicatechin (EC), can alleviate LPS-induced ALI in mice, and if so, whether EC acts by inhibiting p38 MAPK. Read More

Int J Surg Case Rep 2018 Nov 11;53:273-276. Epub 2018 Nov 11.

Logan Hospital, Armstrong + Meadowbrook Roads, Logan, QLD, 4131, Australia; Griffith University, Gold Coast Campus, Southport, QLD, 4215, Australia.

Introduction Parastomal herniation commonly occurs following formation of an end-colostomy or ileostomy. Those patients presenting with acute complications of parastomal hernias typically undergo surgical repair. Stomach-containing parastomal hernias are rare. Read More

Intensive Care Med 2018 Nov 14. Epub 2018 Nov 14.

Department of Gastroenterology, Endocrinology, Diabetology and General Medicine, Kassel Hospital, Kassel, Germany.

Surg Innov 2018 Nov 12:1553350618812322. Epub 2018 Nov 12.

1 Mansoura University, Mansoura, Egypt.

Background: There is paucity of data about the impact of using magnification on rate of pancreatic leak after pancreaticoduodenectomy (PD). The aim of this study was to show the impact of using magnifying surgical loupes 4.0× EF (electro-focus) on technical performance and surgical outcomes of PD. Read More

J Pediatr Surg 2018 Oct 5. Epub 2018 Oct 5.

University of Chicago Medicine Comer Children's Hospital, 5841 S. Maryland Ave, MC 4062, Chicago, IL, USA 60637. Electronic address:

Background/purpose: We examined outcomes before and after implementing an enteral water-soluble contrast protocol for management of pediatric adhesive small bowel obstruction (ASBO).

Methods: Medical records were reviewed retrospectively for all children admitted with ASBO between November 2010 and June 2017. Those admitted between November 2010 and October 2013 received nasogastric decompression with decision for surgery determined by surgeon judgment (preprotocol). Read More

Nurs Child Young People 2018 11 26;30(6):30-37. Epub 2018 Oct 26.

Torbay Hospital, Torquay, England.

Chest X-ray (CXR) is one of the most common radiological investigations undertaken in practice with children. CXRs are requested for a number of suspected diagnoses, including pneumonia, pneumothorax and foreign body aspiration or ingestion. They may also be requested as part of a skeletal survey or to confirm the position of central and umbilical lines, as well as nasogastric tubes. Read More

Child Adolesc Psychiatr Clin N Am 2019 Jan 18;28(1):121-125. Epub 2018 Sep 18.

Department of Psychiatry and Behavioral Sciences, Vanderbilt University Medical Center, 1601 23rd Avenue South, Nashville, TN 37212, USA.

This case provides support for electroconvulsive therapy as a safe treatment in adolescents with a feeding tube. The patient presented to our hospital with symptoms of catatonia with minimal oral intake. She had stopped eating, had minimal interaction with her environment, and spent weeks with a nasogastric tube for nutritional support. Read More

Monaldi Arch Chest Dis 2018 Oct 30;88(3):974. Epub 2018 Oct 30.

University of Padua, Department of Cardiologic, Thoracic and Vascular Sciences.

We report a case of the repair of an acquired benign tracheoesophageal fistula (TEF) after prolonged mechanical invasive ventilation. Patient had an unknown double incomplete aortic arch determining a vascular ring above trachea and esophagus. External tracheobronchial compression, caused by the vascular ring, increasing the internal tracheoesophageal walls pressure determined by endotracheal and nasogastric tubes favored an early TEF development. Read More

Case Rep Infect Dis 2018 2;2018:5067569. Epub 2018 Oct 2.

Laboratorio de Entomología, Instituto de Diagnóstico y Referencia Epidemiológicos, InDRE. Francisco de P. Miranda No. 177, Colonia Unidad Lomas de Plateros, 01480 Ciudad de México, Mexico.

The presence of nosocomial myiasis reflects a lack of adequate medical attention, due to the physical facilities and/or the health care personnel. Patients requiring special attention are more susceptible, such as those with a loss of consciousness, assisted mechanical ventilation, tracheal tubes, or nasogastric probes. Nosocomial myiasis is a rare event that has a greater occurrence in the hospitals of poor and developing countries. Read More

Biofouling 2018 Oct 24:1-15. Epub 2018 Oct 24.

a Laboratório de Estudos Avançados de Microrganismos Emergentes e Resistentes, Departamento de Microbiologia Geral , Instituto de Microbiologia Paulo de Góes, Universidade Federal do Rio de Janeiro , Rio de Janeiro , Brazil.

In the present work, some surface properties of the fungi Scedosporium apiospermum, S. aurantiacum, S. minutisporum, and Lomentospora prolificans and their capability to adhere to and form a biofilm on diverse surfaces were evaluated. Read More

World J Surg 2018 Oct 23. Epub 2018 Oct 23.

Department of Surgery, School of Medicine, Keio University, 35 Shinanomachi, Shinjuku-ku, Tokyo, 160-8582, Japan.

Background: Although esophagectomy is the only curative option for esophageal cancer, the associated invasiveness is high. Nasogastric (NG) tube use may prevent complications; however, its utility remains unclear, and the decompression period depends on the doctor. This study aimed to reveal the effect of conventional versus early NG tube removal on postoperative complications after esophagectomy. Read More

BMC Cancer 2018 Oct 23;18(1):1026. Epub 2018 Oct 23.

Department of Head and Neck, Barretos Cancer Hospital, Rua Antenor Duarte Villela, 1331, Barretos, SP, 14.784-400, Brazil.

Background: The evolution of radiotherapy over recent decades has reintroduced the hypofractionation for many tumor sites with similar outcomes to those of conventional fractionated radiotherapy. The use of hypofractionation in locally advanced head and neck cancer (LAHNC) has been already used, however, its use has been restricted to only a few countries. The aim of this trial was to evaluate the safety and feasibility of moderate hypofractionated radiotherapy (HYP-RT) with concomitant cisplatin (CDDP). Read More

Case Rep Gastrointest Med 2018 24;2018:8714390. Epub 2018 Sep 24.

Department of Medicine, Wayne State University/Detroit Medical Center, Detroit, MI, USA.

Recurrent acute pancreatitis secondary to hypertriglyceridemia (HTG) with levels below 1000 mg/dL has been rarely reported in the literature. HTG is the third most common cause of acute pancreatitis and has been established in the literature as a risk factor when levels are greater than 1000 mg/dL. A 43-year-old patient presented to the hospital with severe epigastric abdominal pain. Read More

Pak J Med Sci 2018 Sep-Oct;34(5):1305-1306

Khalid Siddiqui, Assistant Professor, Department of Anaesthesiology, The Aga Khan University, Karachi Pakistan.

Ann Ital Chir 2018 ;89:305-308

Background And Aims: Ethical and medico-legal issues reviews of Percutaneous Endoscopic Gastrostomy (PEG) placement in elderly patients is an important topic of international medical literature. PEG is often inappropriately placed in patients with not spontaneous oral feeding intake, cause of unrealistic expectations. We performed a critical review of the literature for placement of PEG in geriatric patients. Read More

Br J Anaesth 2018 Nov 31;121(5):1052-1058. Epub 2018 Aug 31.

Department of Anesthesiology and Perioperative Medicine. Electronic address:

Background: Agitation after general anaesthesia can lead to self-harm, violence against staff, and increased resource utilisation. We aimed to assess patient and procedural characteristics associated with this complication in adults.

Methods: We identified cases of agitation (Richmond Agitation-Sedation Scale score +3 or +4, or administration of haloperidol) in patients after general anaesthesia in the PACU from July 1, 2010 to September 30, 2016. Read More

Tunis Med 2018 Feb;96(2):129-134

Objective: In this study, we aimed to analyze the trough plasmatic levels (C0) of the antiepileptic drugs (AED) administered by nasogastric tubes (NGT) in comatose patients and to draw up recommendations for therapeutic drug monitoring (TDM) and for the modalities of AED administration by NGT.

Methods: We conducted a retrospective study on comatose patients addressed over six years and 10 months in Clinical Pharmacology for C0 measurement of AED administered by NGT.

Results: In this study, the sex-ratio was 2. Read More

Clin Exp Gastroenterol 2018 5;11:381-389. Epub 2018 Oct 5.

Department of Clinical Science, Takeda Development Center Americas, Inc., Deerfield, IL, USA,

Objective: To assess the effect of route of administration on the bioavailability of dexlansoprazole 60 mg delayed-release capsule granules.

Methods: One open-label, Phase I, single-dose, 3-period crossover study was conducted in healthy adults. The bioavailability of Dexilant (dexlansoprazole) after dexlansoprazole capsule granules were mixed with water and administered via 16 French nasogastric tube or orally via syringe was compared to administration of the intact capsule in the fasted state, swallowed with water. Read More

J Oral Maxillofac Surg 2018 Sep 20. Epub 2018 Sep 20.

Professor and Program Director, Department of Oral and Maxillofacial Surgery, University of Kentucky, Lexington, KY.

Purpose: To report on dysphagia following orthognathic surgery, to review the literature on this topic, and to make recommendations for the management of this highly unusual problem.

Patients And Methods: Two cases of dysphagia requiring nasogastric feeding tubes following two-jaw surgery are presented adding to the two already reported in the English language. Similarities and possible causes are discussed and the management of this entity is proposed. Read More

Clin Endocrinol (Oxf) 2018 Oct 12. Epub 2018 Oct 12.

The University of Sheffield, Sheffield, UK.

Objective: Hydrocortisone via nasogastric (NG) tube is used in sick children with adrenal insufficiency; however, there is no licensed formulation for NG administration.

Methods: We investigated hydrocortisone recovery after passage through NG tubes in vitro for three formulations: liquid suspension, crushed tablets mixed with water, and hydrocortisone granules designed for oral administration to children. Cortisol was measured by LC-MS/MS. Read More

Int J Gynaecol Obstet 2018 Oct;143 Suppl 2:143-146

Department of Gynecologic Oncology, CMC Hospital, Vellore, TN, India.

Enhanced recovery protocols consist of a bundle of concepts including early feeding, opioid-sparing multimodal pain management, and euvolemia, with the overarching goal of hastening postoperative recovery. Enhanced recovery after surgery has been shown to reduce hospital length of stay, reduce costs, and decrease perioperative opioid requirements in benign and oncologic gynecologic surgery. Interventions without supporting evidence of benefit, such as the use of mechanical bowel preparation, routine use of nasogastric tubes and surgical drains, caloric restriction, routine use of intravenous opioid analgesics, and over-vigorous intravenous hydration should be discouraged to improve broader endpoints such as patient satisfaction and overall recovery. Read More

Int J Colorectal Dis 2018 Oct 6. Epub 2018 Oct 6.

Department of Visceral Surgery, CHU Clermont-Ferrand, 63003, Clermont Ferrand, France.

Purpose: Postoperative ileus (POI) occurrence within enhanced recovery programs (ERPs) has decreased. Also, intra-abdominal complications (IAC) such as anastomotic leakage (AL) generally present late. The aim was to characterize the link between POI and the other complications occurring after surgery. Read More

Br J Nurs 2018 Oct;27(18):1036-1041

Statistician, Department of Engineering Design and Mathematics, University of the West of England, Bristol.

Over 50 % of tape-secured feeding tubes are inadvertently lost. The impact of nasal bridle securement on nasogastric (NG) and nasointestinal (NI) tube loss, outcome and duration of use was determined from 1 October 2014 (NG) and 1 January 2010 respectively to 31 December 2017. From this and published data, the potential impact of nasal bridles on major complications was determined. Read More

J Gastric Cancer 2018 Sep 16;18(3):230-241. Epub 2018 Aug 16.

Division of Surgical Oncology, Department of Surgery, City of Hope National Medical Center, Duarte, CA, USA.

Purpose: Enhanced recovery after surgery (ERAS) protocols for gastric cancer patients have shown improved outcomes in Asia. However, data on gastric cancer ERAS (GC-ERAS) programs in the United States are sparse. The purpose of this study was to compare perioperative outcomes before and after implementation of an GC-ERAS protocol at a National Comprehensive Cancer Center in the United States. Read More

Anticancer Res 2018 Oct;38(10):5581-5587

Department of Medical and Surgical Sciences and Translational Medicine, Faculty of Medicine and Psychology, Sapienza University, St. Andrea Hospital, Rome, Italy.

Background/aim: Endoscopic vacuum-assisted closure therapy (EVAC) is a promising new technique for repairing upper gastrointestinal defects of different etiologies. As of 2018, however, no standardized recommendation exists. This article reviewed EVAC in treating anastomotic leakage following major resective surgery of esophageal (EC) and gastric cancer (GC). Read More

Nutr Cancer 2018 Oct 1:1-6. Epub 2018 Oct 1.

d Department of Oncology and Haematology , Cantonal Hospital , St. Gallen , Switzerland.

To compare safety and effectiveness of prolonged (>28 days) versus short duration (≤28 days) use of nasogastric tube for enteral nutrition and weight loss prevention during curative radiotherapy with or without concurrent chemotherapy or cetuximab for head and neck cancer patients. We performed a retrospective study and database review of all patients at our center, treated with radiotherapy for head and neck cancer receiving enteral nutrition by nasogastric tube. Type of treatment, weight and body mass index changes, and related complications (gastroesophageal reflux, pneumonia, ulcer, feeding tube obstruction, or dislocation) were documented. Read More

World J Pediatr 2018 Oct 29;14(5):429-436. Epub 2018 Sep 29.

Department of Gastroenterology, Guangzhou Women and Children's Medical Center, Guangzhou, 510623, China.

Background: The guidelines addressed the evidence-based indications for the management of children with acute infectious diarrhea in Chinese pediatric population.

Data Sources: The experts group of evidence development put forward clinical problems, collects evidence, forms preliminary recommendations, and then uses open-ended discussions to form recommendations. The literature review was done for developing this guideline in databases including PubMed, Cochrane, EMBASE, China Biomedical Database, and Chinese Journal Full-text Database up to June 2013. Read More

BMC Infect Dis 2018 Sep 29;18(1):491. Epub 2018 Sep 29.

Department of Hospital Infection Control, Chinese PLA Institute for Disease Control and Prevention, 20# Dongda Str, Beijing, 100071, China.

Background: Carbapenem resistance in Acinetobacter baumannii in China was mainly mediated by OXA-23-like carbapenemases, while OXA-24/40-like carbapenemases were rarely identified. OXA-72 is one variant of OXA-24/40-like carbapenemases. This study aimed to demonstrate the epidemiology and characterizations of OXA-72-producing A. Read More

Cureus 2018 Jul 25;10(7):e3046. Epub 2018 Jul 25.

MEDIC, Cardiff University, Cardiff, GBR.

This case study presents a patient who has undergone right carotid endarterectomy complicated by glossopharyngeal nerve (or cranial nerve (CN) IX) injury. The patient had one transient ischaemic attack (TIA) three weeks before admission. A computed tomography (CT) scan two days after admission illustrated a right-sided parietal infarct. Read More

J Eat Disord 2018 26;6:22. Epub 2018 Sep 26.

Division of Adolescent/Young Adult Medicine, Boston Children's Hospital, Department of Pediatrics, Harvard Medical School, 300 Longwood Avenue, Boston, MA 02115 USA.

Background: Avoidant/restrictive food intake disorder (ARFID) was added to the Diagnostic and Statistical Manual of Mental Disorders Fifth Edition in 2013. ARFID can result in impaired growth and significant nutritional deficiency; individuals with ARFID may be so nutritionally compromised that they require medical stabilization in a hospital. Prior to the new diagnostic criteria, it is unclear how patients now diagnosed with ARFID may have been medically stabilized when hospitalized. Read More

Nutr Clin Pract 2018 Sep 25. Epub 2018 Sep 25.

Division of Geriatric Medicine, Department of Medicine, Faculty of Medicine, University of Malaya, Kuala Lumpur, Malaysia.

Background: A barrier to gastrostomy feeding exists among Asian clinicians and caregivers due to negative perceptions regarding complications. We compared clinical and nutrition outcomes in older dysphagic Asian patients with nasogastric (NG) or gastrostomy tube feeding using a pragmatic study design.

Methods: The choice of enteral tube access was determined by managing clinicians and patients/caregivers. Read More

Frontline Gastroenterol 2018 Oct 29;9(4):250-255. Epub 2018 Apr 29.

School of Medicine, Medical Sciences and Nutrition, University of Aberdeen, Aberdeen, UK.

Background: Interest in the use of faecal microbiota transplantation (FMT) in inflammatory bowel disease (IBD) has increased following outcomes in patients with infection (CDI). While research exploring clinician awareness and attitude towards the use of FMT in CDI has been carried out, data for IBD are currently lacking.

Objective: To assess the perceptions of gastroenterologists and current practice relating to FMT as a treatment for IBD in the UK. Read More

Gynecol Oncol 2018 11 21;151(2):282-286. Epub 2018 Sep 21.

Division of Gynecologic Oncology, University of Alabama at Birmingham, Birmingham, AL, United States.

Objective: To evaluate the impact of enhanced recovery after surgery (ERAS) on postoperative gastrointestinal function in gynecologic oncology patients.

Methods: This retrospective cohort study compared gynecology oncology patients undergoing non-emergent laparotomy from 10/2016 to 6/2017 managed on an ERAS protocol to a control cohort from the year prior to ERAS implementation. Major changes to postoperative care after ERAS implementation included multimodal analgesia, early feeding, goal-directed fluid resuscitation, and early ambulation. Read More

J Vet Pharmacol Ther 2018 Sep 22. Epub 2018 Sep 22.

Department of Farm Animals and Veterinary Public Health, Institute for Animal Nutrition and Functional Plant Compounds, University of Veterinary Medicine, Vienna, Austria.

Devil's claw is used for the treatment of inflammatory symptoms and degenerative disorders in horses since many years, but without the substantive pharmacokinetic data. The pharmacokinetic parameters of harpagoside, the main active constituent of Harpagophytum procumbens DC ex Meisn., were evaluated in equine plasma after administration of Harpagophytum extract FB 8858 in an open, single-dose, two-treatment, two-period, randomized cross-over design. Read More

Am J Med Genet A 2018 Sep 21;176(9):1865-1871. Epub 2018 Sep 21.

Department of Pediatrics. ASST-Lariana. Sant'Anna Hospital, San Fermo della Battaglia (Como), Italy.

Cornelia de Lange syndrome (CdLS) is a genetic condition characterized by intellectual disability, peculiar facial dysmorphisms, multiorgan malformations, and growth problems. Majority cases of CdLS are caused by mutations in genes of Cohesin pathway. Although feeding problems are a well-known feature, no specific data have been published about the use of nutritional devices. Read More

Anesth Analg 2018 Sep 18. Epub 2018 Sep 18.

From the Department of Anesthesiology and Perioperative Medicine, Division of Pediatric Anesthesiology, David Geffen School of Medicine at University of California, Los Angeles, California.

Background: Hypertrophic pyloric stenosis in infants can cause a buildup of gastric contents. Orogastric tubes (OGTs) or nasogastric tubes (NGTs) are often placed in patients with pyloric stenosis before surgical management to prevent aspiration. However, exacerbation of gastric losses may lead to electrolyte abnormalities that can delay surgery, and placement has been associated with increased risk of postoperative emesis. Read More

Adv Med Educ Pract 2018 7;9:639-648. Epub 2018 Sep 7.

Education Office, Sydney Medical School, The University of Sydney, Sydney, NSW, 2050, Australia.

Introduction: On commencing internship, new medical graduates (new interns) are often required to perform core procedural skills under differing levels of supervision. This variability of knowledge and experience with procedural skills can place patient safety at risk. Consequently, in 2012, we developed a targeted, intensive, 3-day training course for our pre-intern (PrInt) students. Read More

Int J STD AIDS 2018 Sep 19:956462418797847. Epub 2018 Sep 19.

1 Infectious Diseases Department, České Budějovice Hospital, České Budějovice, Czech Republic.

Alternative modes of antiretroviral administration are sought for people with impaired intestinal passage and/or absorption. We present a case of late HIV diagnosis (CD4+ count 160 cells/µL) with gastric outlet obstruction due to stomach adenocarcinoma. Co-morbidities included oesophageal candidiasis, Helicobacter pylori-positive duodenal ulcers and cytomegalovirus duodenitis. Read More