218,629 results match your criteria Nasal Fracture Imagings

Research Progress on the SERPINE1 Protein and Chronic Inflammatory Diseases of the Upper Respiratory Tract: A Literature Review.

Int Arch Allergy Immunol 2021 May 4:1-6. Epub 2021 May 4.

Department of Otolaryngology, The First Affiliated Hospital of Guangzhou University of Chinese Medicine, Guangzhou, China.

SERPINE1 protein is one important member of the serine proteinase inhibitor E superfamily that plays a crucial role in the fibrinolytic system. It has been identified which is related to chronic inflammatory lung diseases like allergic asthma and lung fibrosis. Recently, researchers have focused on the impact of SERPINE1 and its genetic polymorphisms on inflammatory diseases of the upper respiratory tract. Read More

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Evaluation of an antigen-based test for hospital point-of-care diagnosis of SARS-CoV-2 infection.

J Clin Virol 2021 Apr 21;139:104838. Epub 2021 Apr 21.

Microbiology and Virology Unit, University Hospital Città della Salute e della Scienza di Torino, Turin, Italy.

Background: An accurate diagnosis is essential to identify and manage SARS-CoV-2 infected patients and implement infection control measures. Although real-time reverse transcription polymerase chain reaction (RT-PCR) is the current recommended laboratory method, several rapid antigen point-of-care tests (POCTs) were developed as frontline testing for SARS-CoV-2 infection diagnosis.

Objectives: The aim of this study was to assess a recently CE-approved POCT, SARS-CoV-2 Ag Test on the LumiraDx™ Platform (LumiraDx GmbH, Cologne, Germany) for the identification of SARS-COV-2 infected subjects at hospital setting. Read More

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Higenamine alleviates allergic rhinitis by activating AKT1 and suppressing the EGFR/JAK2/c-JUN signaling.

Phytomedicine 2021 Apr 20;86:153565. Epub 2021 Apr 20.

School of Traditional Chinese Medicine, Southern Medical University, Guangzhou 510515, China; Guangzhou Provincial Key Laboratory of Chinese Medicine Pharmaceutics, Guangzhou 510515, China; Guangdong Provincial Engineering Laboratory of Chinese Medicine Preparation Technology, Guangzhou 510515, China. Electronic address:

Background: Allergic rhinitis (AR) is an inflammatory, immunoglobulin E (IgE)-mediated disease characterized by the typical symptoms of sneezing, rhinorrhea, nasal itching, and congestion. Higenamine (HG) is a plant-based alkaloid, possesses a wide range of activities, including vascular and tracheal relaxation, antioxidative, antiapoptotic, anti-inflammatory, and immunomodulatory activities. So far, the effect and the underlying mechanism of HG on AR have not been studied. Read More

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Prevalence of COVID-19 in children, adolescents, and adults in remote education situation in the city of Fortaleza - Brazil.

Int J Infect Dis 2021 May 1. Epub 2021 May 1.

Biotechnology and Molecular Biology Laboratory, State University of Ceará, Campus do Itaperi, 60714-903 Fortaleza, CE, Brazil.

Objectives: A retrospective study was conducted on a database of the COVID-19 Tracking Program in schoolchildren to identify the prevalence of COVID-19 through serology and RT-PCR in children, adolescents, and adults.

Methods: The data was composed of sociodemographic and clinical variables, results of serological tests (IgM and IgG), and RT-PCR results of IgM-positive individuals. The statistical analysis was performed with a 5% significance level. Read More

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Article Topic/Title: Primary cutaneous T-cell lymphomas other than Mycosis Fungoides and Sezary Syndrome. Part II: Prognosis and Management.

J Am Acad Dermatol 2021 May 1. Epub 2021 May 1.

Memorial Sloan Kettering Cancer Center, New York, NY. Electronic address:

Primary cutaneous T-cell lymphomas (CTCLs) other than Mycosis Fungoides (MF) and Sézary syndrome (SS) encompass a heterogenous group of non-Hodgkin lymphomas with variable clinical course, prognoses, and management. With morphologic and histologic overlap among the CTCL subtypes and other T-cell lymphomas with cutaneous manifestations, thorough evaluation with clinicopathologic correlation and exclusion of systemic involvement are essential prior to initiating therapy. Staging and treatment recommendations vary depending on the subtype, clinical behavior, and treatment response. Read More

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Management of the COVID-19 epidemic in a French immigration detention center.

Int J Prison Health 2021 May;ahead-of-print(ahead-of-print)

Medico-Judicial Unit, Hôtel-Dieu, Assistance Publique - Hopitaux de Paris, Paris, France.

Purpose: The purpose of this paper is to give an overview of management of the COVID-19 epidemic in a French immigration detention center.

Design/methodology/approach: During containment in France because of COVID-19, the judicial authorities had to deal with the risk of contamination within immigration detention centers (IDC). In the Paris IDC, which can usually receive up to 240 individuals, measures have been taken to limit the risk of contamination by releasing individuals without prior judicial conviction and testing the others by a nasal swab. Read More

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Cross-Cultural Evaluation of the Dutch FACE-Q Rhinoplasty Questionnaires Using Rasch Analysis.

Aesthet Surg J 2021 May 4. Epub 2021 May 4.

Department of Physical and Occupational Therapy, University Hospital Hvidovre-Amager, Hvidovre, Denmark.

Background: The English version of the FACE-Q rhinoplasty module was developed according to Rasch measurement theory by Klassen et al. in 2010 and recently translated into Dutch. Before conclusions can be drawn from the Dutch version, this translation must also fit the item analysis by the Rasch model. Read More

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Small molecule natural products in human nasal/oral microbiota.

J Ind Microbiol Biotechnol 2021 Feb 6. Epub 2021 Feb 6.

Department of Chemical and Biomolecular Engineering, University of California, Berkeley, Berkeley 94720, USA.

Small molecule natural products are a chemically diverse class of biomolecules that fulfill myriad biological functions, including autoregulation, communication with microbial neighbors and the host, interference competition, nutrient acquisition, and resistance to oxidative stress. Human commensal bacteria are increasingly recognized as a potential source of new natural products, which may provide insight into the molecular ecology of many different human body sites as well as novel scaffolds for therapeutic development. Here, we review the scientific literature on natural products derived from residents of the human nasal/oral cavity, discuss their discovery, biosynthesis, and ecological roles, and identify key questions in the study of these compounds. Read More

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February 2021

Increased risk of respiratory viral infections in elite athletes: A controlled study.

PLoS One 2021 4;16(5):e0250907. Epub 2021 May 4.

Department of Pediatrics and Adolescent Medicine, Turku University Hospital and University of Turku, Turku, Finland.

Background: Respiratory symptoms are commonly recognised in elite athletes. The occurrence, etiology and clinical presentation of the illnesses in athletes is unclear.

Methods: We performed a prospective controlled study of respiratory viral infections in Team Finland during Nordic World Ski Championships 2019. Read More

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Monitoring health care workers at risk for COVID-19 using wearable sensors and smartphone technology: Protocol for an observational mobile health study.

JMIR Res Protoc 2021 May 3. Epub 2021 May 3.

Division of Pediatric Hematology/Oncology, Department of Pediatrics, University of Michigan, 1500 E. Medical Center DrD4118 Medical Professional Building, Ann Arbor, US.

Background: Health care workers (HCWs) have been working in the frontlines of the COVID-19 pandemic with high risks of viral exposure, infection, and transmission. Standard COVID-19 testing is insufficient to protect HCWs from these risks and prevent the spread of disease. Continuous monitoring of physiological data with wearable sensors, self-monitoring of symptoms, and asymptomatic COVID testing may aid in the early detection of COVID-19 in HCWs and may help reduce further transmission among HCWs, patients, and families. Read More

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Use of Continuous Cranial Shape Variation in the Identification of Divergent Crocodile Species of the Genus Mecistops.

J Morphol 2021 May 4. Epub 2021 May 4.

Institute of Environment, Florida International University, North Miami, FL.

The discovery of cryptic biodiversity has blossomed under the advancements of genetic techniques, but species identification via morphology remains crucial to effective conservation efforts. In this study, we tested the use of continuous cranial shape variation in distinguishing the two living species of Mecistops: the West African slender-snouted crocodile (M. cataphractus) and the Central African slender-snouted crocodile (M. Read More

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Forensic Recreation and Visual Representation of Greek Orthodox Church Saint Eftychios of Crete.

Adv Exp Med Biol 2021 ;1317:17-33

Plastic Surgery Unit, Surgical Oncology Clinic, General University Hospital of Heraklion, Heraklion, Greece.

Facial reconstruction is employed in medical science and archaeology. Though quite popular as anthropological method, it has not so far been used in the orthodox ecclesiastical tradition. This work presents the facial reconstruction of St Eftychios of Crete, who lived between the ninth and tenth centuries. Read More

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January 2021

Retinal nerve fiber layer thickness measured by optical coherence tomography predicts visual recovery after orbital decompression for dysthyroid optic neuropathy.

Int Ophthalmol 2021 May 4. Epub 2021 May 4.

Department of Ophthalmology, Union Hospital, Tongji Medical College, Huazhong University of Science and Technology, Jiefang Road 1277, Wuhan, 430022, Hubei Province, China.

Purpose: To determine the prognostic value of optical coherence tomography (OCT) measurement of the peripapillary retinal nerve fiber layer (RNFL) thickness in visual recovery after orbital decompression of patients with dysthyroid optic neuropathy (DON).

Methods: A total of 52 eyes of 37 patients who underwent orbital decompression for DON between 2013 and 2019 were retrospectively reviewed. We examined peripapillary RNFL thickness, best-corrected visual acuity (BCVA), visual field (VF) for mean deviation (MD) and pattern standard deviation (PSD), and pattern-reversed visual evoked potential (PVEP) for P100 latency and amplitude before and after surgery. Read More

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Toxicokinetic and Genotoxicity Study of NNK in Male Sprague-Dawley Rats Following Nose-Only Inhalation Exposure, Intraperitoneal Injection, and Oral Gavage.

Toxicol Sci 2021 May 3. Epub 2021 May 3.

National Center for Toxicological Research (NCTR), U.S. Food and Drug Administration (FDA), Jefferson, AR 72079.

The tobacco-specific nitrosamine NNK [4-(methylnitrosamino)-1-(3-pyridyl)-1-butanone] is found in tobacco products and tobacco smoke. NNK is a potent genotoxin and human lung carcinogen; however, there are limited inhalation data for the toxicokinetics (TK) and genotoxicity of NNK in vivo. In the present study, a single dose of 5x10-5, 5x10-3, 0. Read More

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Saliva and its potential in covid-19 cannot be ignored: a point of view.

Infect Control Hosp Epidemiol 2021 May 4:1-5. Epub 2021 May 4.

Associate professor, Conservative dentistry and endodontics, ESIC dental college, Rohini, Guru Gobind Singh Indraprastha

It has been demonstrated that salivary gland duct cells have similar receptors as ACE2-positive cells/keratin epithelial cells of the lung which have high potential to be infected by SARS-CoV 2 virus. The aerosols carrying virus have penetration into the healthy human body and lungs via inhalation through nose or mouth. Read More

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Anatomical effects of intravitreal anti-vascular endothelial growth factor injections on inner layers of the lesion-free retina.

Cutan Ocul Toxicol 2021 May 4:1-5. Epub 2021 May 4.

Ophthalmology Department, Sultan 2. Abdulhamid Han Training and Research Hospital, University of Health Sciences, Istanbul, Turkey.

Purpose: The primary aim of the study was to investigate the effects of anti-vascular endothelial growth factor (VEGF) injections on the inner retinal layer anatomy of the lesion-free retina in eyes treated for neovascular age-related macular degeneration (nAMD). The secondary aim was to compare the changes of inner retinal layers in the lesion-free region of treated eyes with the same region of the untreated, fellow eyes and, thus, to elucidate any adverse effect of anti-VEGF treatments independently of 1-year aging changes.

Methods: This was a retrospective, longitudinal, case-control study of 50 eyes of 25 patients. Read More

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Innate and acquired immune responses of colostrum-fed neonatal Holstein calves following intranasal vaccination with two commercially available modified-live virus vaccines.

J Am Vet Med Assoc 2021 May;258(10):1119-1129

Objective: To compare immune responses induced by 2 commercially available vaccines with a bovine herpesvirus type 1 (BHV1) component following intranasal (IN) administration to colostrum-fed calves.

Animals: 90 male Holstein calves (ages, 5 to 14 days).

Procedures: In a randomized complete block design, each calf received 2 mL (1 mL/nostril) of vaccine A (n = 30), vaccine B (30), or saline (0. Read More

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Nicoletella semolina in the airways of healthy horses and horses with severe asthma.

J Vet Intern Med 2021 May 4. Epub 2021 May 4.

Clinical Sciences Department, Faculté de Médecine Vétérinaire, Université de Montréal, Montreal, Quebec, Canada.

Background: Nicoletella semolina was identified in the airways of horses and its low prevalence could be because of its difficult differentiation from other Pasteurellaceae.

Objectives: To develop a molecular method for the identification of N. semolina and to evaluate its prevalence in the mouth and the airways of healthy and severe asthmatic horses. Read More

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High-flow nasal cannula for oxygenation during emergency tracheal stenting under flexible bronchoscopy guidance.

Lung India 2021 May-Jun;38(3):269-272

Department of Pulmonary, Critical Care and Sleep Medicine, All India Institute of Medical Sciences, New Delhi, India.

Central airway obstruction is a common complication of advanced esophageal carcinoma requiring bronchoscopic evaluation and intervention by a pulmonologist. Airway assessment by flexible bronchoscopy is crucial for the selection of the most suitable modality for the management of central airway obstruction. In such situations, flexible bronchoscopy may however be complicated by the development of hypoxemia. Read More

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Sniff-synchronized, gradient-guided olfactory search by freely-moving mice.

Elife 2021 May 4;10. Epub 2021 May 4.

Institute of Neuroscience; Department of Psychology, University of Oregon, Eugene, OR, United States.

For many organisms, searching for relevant targets such as food or mates entails active, strategic sampling of the environment. Finding odorous targets may be the most ancient search problem that motile organisms evolved to solve. While chemosensory navigation has been well characterized in micro-organisms and invertebrates, spatial olfaction in vertebrates is poorly understood. Read More

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Effects of 0.5% and 2.0% Sodium Lauryl Sulfate in Male CD-1 Mice From a 3-Month Oral Gavage Toxicity Study.

Toxicol Pathol 2021 May 4:1926233211004873. Epub 2021 May 4.

Nonclinical Study Management, Eli Lilly and Company, Indianapolis, IN, USA.

The tolerability of single daily gavage doses of 0.5% or 2.0% (wt/vol) sodium lauryl sulfate (SLS) in 11- to 12-week-old male CD-1 mice was evaluated in a study of 3 months in duration. Read More

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Evaluation of diazepam nasal spray in patients with epilepsy concomitantly using maintenance benzodiazepines: An interim subgroup analysis from a phase 3, long-term, open-label safety study.

Epilepsia 2021 May 4. Epub 2021 May 4.

Neurelis, Inc, San Diego, CA, USA.

Objective: Diazepam nasal spray (Valtoco), indicated for acute treatment of frequent seizure activity (seizure clusters) in patients with epilepsy ≥6 years of age, is designed to be a rapid, noninvasive, socially acceptable route of administration. This interim analysis evaluated the safety profile of diazepam nasal spray in patients with and without concomitant use of benzodiazepines, with use of a second dose for a seizure cluster as a proxy for effectiveness.

Methods: A long-term, phase 3, open-label safety study enrolled patients with epilepsy who had seizures despite a stable antiseizure medication regimen. Read More

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[Postoperative treatment following paranasal sinus surgery].

HNO 2021 May 3. Epub 2021 May 3.

HNO-Klinik, Städtisches Klinikum Karlsruhe, Moltkestraße 90, 76133, Karlsruhe, Deutschland.

Postoperative care is a crucial aspect for the success of paranasal sinus interventions. Basic procedures include saline nasal wash, which should be started on the first postoperative day, topical steroids, and antibiotics in cases of infection. Medical treatment involves aspiration of secretion in the inferior meatus during the first week. Read More

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Smell impairment in patients with chronic rhinosinusitis: a real-life study.

Eur Arch Otorhinolaryngol 2021 May 3. Epub 2021 May 3.

Allergy Office, Casa Di Cura Villa Montallegro, Genoa, Italy.

Objective: Chronic rhinosinusitis with nasal polyps (CRSwNP) is a frequently occurring condition involving type 2 inflammation. It has a global prevalence of approximately 4% and has a major effect on the quality of life of those affected by it. CRSwNP is a complex condition for otorhinolaryngologists to manage, since its precise pathogenic basis has not been established, treatment is challenging and the condition often recurs. Read More

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COVID-19 in a Mississippi Community Hospital.

South Med J 2021 05;114(5):305-310

From the Department of Medicine, Pulmonary, and Critical Care, the Department of Medicine and Infectious Disease, the Department of Clinical Research, the Department of Infection Prevention, and the Department of Medicine, Singing River Health System, Ocean Springs, Mississippi.

Objectives: Mississippi recorded the first case of coronavirus disease 2019 (COVID-19) on March 11, 2020. This report describes the initial COVID-19 experience of the single healthcare system serving Jackson County, Mississippi. The intent of this retrospective review of COVID-19 hospitalized patients was to identify any characteristics or interventions amenable to improving care management and clinical outcomes for patients within our community hospital. Read More

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cell culture model of human nasal-associated lymphoid tissue (NALT) to evaluate the humoral immune response to SARS-CoV-2 spike proteins.

Saudi J Biol Sci 2021 Apr 24. Epub 2021 Apr 24.

Otorhinolaryngology, Head& Neck Surgery Department, Faculty of Medicine, Taibah University, Madinah, Saudi Arabia.

To date, coronavirus disease 2019 (COVID-19) continues to be considered a pandemic worldwide, with a mild to severe disease presentation that is sometimes associated with serious complications that are concerning to global health authorities. Scientists are working hard to understand the pathogenicity of this novel virus, and a great deal of attention and effort has been focused on identifying therapeutics and vaccines to control this pandemic.

Methods: This study used tonsils removed from twelve patients who underwent an elective tonsillectomy in the ear, nose, and throat (ENT) department at Saudi Germany Hospital, Madinah, Saudi Arabia. Read More

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Feasibility of Pediatric Non-Invasive Respiratory Support in Low and Middle-Income Countries.

Indian Pediatr 2021 May 3. Epub 2021 May 3.

Division of Pediatric Pulmonology and Intensive Care, Department of Pediatrics, All India Institute of Medical Sciences, New Delhi, India. Correspondence to: Dr Rakesh Lodha, Professor, Division of Pediatric Pulmonology and Intensive Care, Department of Pediatrics, All India Institute of Medical Sciences, New Delhi, Ansari Nagar, New Delhi,110 029, India.

Non-Invasive respiratory support can be viewed as mechanical respiratory support without endotracheal intubation and it includes Continuous Positive Airway Pressure, Bi-Level Positive Airway Pressure, High Flow Nasal Cannula, and Non-invasive Positive Pressure Ventilation. Over past few years, non-invasive respiratory support is getting more popular across pediatric intensive care units for acute respiratory failure as well as for long-term ventilation support at home. It reduces the need for invasive mechanical ventilation, decreases the risk of nosocomial pneumonia as well as mortality in selected pediatric and adult population. Read More

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Interocular Suppression in Primary Visual Cortex in Strabismus.

J Neurosci 2021 May 3. Epub 2021 May 3.

Program in Neuroscience, Department of Ophthalmology, University of California, San Francisco, San Francisco, CA 94143 USA

People with strabismus acquired during childhood do not experience diplopia (double vision). To investigate how perception of the duplicate image is suppressed, we raised two male monkeys with alternating exotropia by disinserting the medial rectus muscle in each eye at age 4 weeks. Once the animals were mature, they were brought to the laboratory and trained to fixate a small spot while recordings were made in V1. Read More

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Development and Preclinical Evaluation of New Inhaled Lipoglycopeptides for the Treatment of Persistent Pulmonary MRSA Infections.

Antimicrob Agents Chemother 2021 May 3. Epub 2021 May 3.

Insmed Incorporated, Bridgewater, New Jersey, USA

Chronic pulmonary MRSA disease in cystic fibrosis (CF) has a high probably of recurrence following treatment with standard-of-care antibiotics and represents an area of unmet need associated with reduced life expectancy. We developed a lipoglycopeptide therapy customized for pulmonary delivery that not only demonstrates potent activity against planktonic MRSA but also against protected colonies of MRSA both in biofilms and within cells, the latter of which have been linked to clinical antibiotic failure. A library of next-generation potent lipoglycopeptides were synthesized with an emphasis on attaining superior pharmacokinetics (PK) and pharmacodynamics to similar compounds of their class. Read More

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