5,331 results match your criteria Narcolepsy


Untangling Narcolepsy and Diabetes: Pathomechanisms with Eyes on Therapeutic Options.

Brain Res 2019 Apr 15. Epub 2019 Apr 15.

Student's Scientific Research Center (SSRC), Tehran University of Medical Sciences, Tehran, Iran; NeuroImaging Network (NIN), Universal Scientific Education and Research Network (USERN), Tehran, Iran. Electronic address:

Narcolepsy (NA) is a primary sleep disorder characterized by loss of hypocretinergic/orexinergic neurons. NA is associated with an increased risk for metabolic disorders such as diabetes mellitus (DM). Proposed mechanisms for this association are alterations in food intake, disruption of energy balance, glucose tolerance, and insulin sensitivity, as well as inflammation and genetic factors. Read More

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http://dx.doi.org/10.1016/j.brainres.2019.04.013DOI Listing

Prevalence of Rapid Eye Movement-related Obstructive Sleep Apnea in Adult Narcolepsy.

Intern Med 2019 Apr 17. Epub 2019 Apr 17.

Department of Sleep Medicine and Sleep Disorders Center, Aichi Medical University Hospital, Japan.

Objective The association between narcolepsy and rapid eye movement (REM)-related obstructive sleep apnea (OSA) has not been reported. This study aimed to examine the prevalence of REM-related OSA in narcolepsy patients. Methods From January 2013 to April 2018, 141 adult patients were diagnosed with narcolepsy using nocturnal polysomnography and the multiple sleep latency test. Read More

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http://dx.doi.org/10.2169/internalmedicine.2601-18DOI Listing

Using a Facebook Forum to Cope With Narcolepsy After Pandemrix Vaccination: Infodemiology Study.

J Med Internet Res 2019 Apr 16;21(4):e11419. Epub 2019 Apr 16.

School of Business, Örebro University, Örebro, Sweden.

Background: In 2010, newly diagnosed narcolepsy cases among children and adolescents were seen in several European countries as a consequence of comprehensive national vaccination campaigns with Pandemrix against H1N1 influenza. Since then, a large number of people have had to live with narcolepsy and its consequences in daily life, such as effects on school life, social relationships, and activities. Initially, the adverse effects were not well understood and there was uncertainty about whether there would be any financial compensation. Read More

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http://www.jmir.org/2019/4/e11419/
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http://dx.doi.org/10.2196/11419DOI Listing
April 2019
1 Read

Orexin secretion abnormality involved in excessive somnolence in CNS lymphoma without hypothalamic lesions.

J Clin Neurosci 2019 Apr 5. Epub 2019 Apr 5.

Department of Gastroenterology and Neurology, Kagawa University Faculty of Medicine, 1750-1 Ikenobe, Miki-cho, Kita-gun, Kagawa 761-0793, Japan.

A 72-year-old woman developed excessive somnolence as one of the symptoms of diffuse large B-cell lymphoma in the central nervous system (CNS). Although somnolence might be caused by reduced orexin secretion associated with hypothalamic lesions, neither brain MRI nor 18F-fluorodeoxyglucose positron emission tomography identified hypothalamic lesions. However, the decreased cerebrospinal fluid (CSF) orexin levels recovered to near normal values with improvement of somnolence after chemotherapy. Read More

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http://dx.doi.org/10.1016/j.jocn.2019.03.066DOI Listing
April 2019
1 Read

Neurophysiological signature of gamma-hydroxybutyrate augmented sleep in male healthy volunteers may reflect biomimetic sleep enhancement: a randomized controlled trial.

Neuropsychopharmacology 2019 Apr 8. Epub 2019 Apr 8.

Institute of Pharmacology and Toxicology, University of Zürich, Zürich, Switzerland.

Gamma-hydroxybutyrate (GHB) is an endogenous GHB/GABA receptor agonist, which has demonstrated potency in consolidating sleep and reducing excessive daytime sleepiness in narcolepsy. Little is known whether GHB's efficacy reflects the promotion of physiological sleep mechanisms and no study has investigated its sleep consolidating effects under low sleep pressure. GHB (50 mg/kg p. Read More

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http://dx.doi.org/10.1038/s41386-019-0382-zDOI Listing
April 2019
1 Read

Trace amine-associated receptor 1 agonism promotes wakefulness without impairment of cognition in Cynomolgus macaques.

Neuropsychopharmacology 2019 Apr 6. Epub 2019 Apr 6.

Center for Neuroscience, Biosciences Division, SRI International, Menlo Park, CA, 94025, USA.

Trace amine-associated receptor 1 (TAAR1) is a G-protein coupled receptor with affinity for the trace amines. TAAR1 agonists have pro-cognitive, antidepressant-, and antipsychotic-like properties in both rodents and non-human primates (NHPs). TAAR1 agonism also increases wakefulness and suppresses rapid-eye movement (REM) sleep in mice and rats and reduces cataplexy in two mouse models of narcolepsy. Read More

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http://dx.doi.org/10.1038/s41386-019-0386-8DOI Listing
April 2019
1 Read

Shared T cell receptor chains in blood memory CD4 T cells of narcolepsy type 1 patients.

J Autoimmun 2019 Apr 2. Epub 2019 Apr 2.

Centre de Physiopathologie Toulouse-Purpan (CPTP), Université de Toulouse, CNRS, Inserm, UPS, Toulouse, France. Electronic address:

Convergent evidence points to the involvement of T cells in the pathogenesis of narcolepsy type 1 (NT1). Here, we hypothesized that expanded disease-specific T cell clones could be detected in the blood of NT1 patients. We compared the TCR repertoire of circulating antigen-experienced CD4 and CD8 T cells from 13 recently diagnosed NT1 patients and 11 age-, sex-, and HLA-DQB1*06:02-matched healthy controls. Read More

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http://dx.doi.org/10.1016/j.jaut.2019.03.010DOI Listing
April 2019
2 Reads

Differentiation of endogenous and exogenous γ-Hydroxybutyrate in rat and human urine by GC/C/IRMS.

Int J Legal Med 2019 Apr 2. Epub 2019 Apr 2.

College of Pharmacy, Duksung Women's University, Seoul, 01369, South Korea.

Gamma (γ)-hydroxybutyric acid (GHB) has been reported to be an endogenous compound in the mammalian brain. It used to treat symptoms of alcohol, opioid, and drug withdrawal and cataplexy of narcolepsy. However, it is often used for criminal purposes because it is colorless, tasteless, and has short half-life. Read More

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http://link.springer.com/10.1007/s00414-019-02052-x
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http://dx.doi.org/10.1007/s00414-019-02052-xDOI Listing
April 2019
4 Reads

[An autoimmune basis for narcolepsy type 1?]

Med Sci (Paris) 2019 Mar 1;35(3):204-207. Epub 2019 Apr 1.

Centre de physiopathologie Toulouse-Purpan (CPTP), Université de Toulouse, CNRS, Inserm, UPS, CHU Purpan - BP 3028 - 31024 Toulouse Cedex 3, France.

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http://dx.doi.org/10.1051/medsci/2019041DOI Listing
March 2019
2 Reads

The Functional Role of Dreaming in Emotional Processes.

Front Psychol 2019 15;10:459. Epub 2019 Mar 15.

Department of Psychology, Sapienza University of Rome, Rome, Italy.

Dream experience (DE) represents a fascinating condition linked to emotional processes and the human inner world. Although the overlap between REM sleep and dreaming has been overcome, several studies point out that emotional and perceptually vivid contents are more frequent when reported upon awakenings from this sleep stage. Actually, it is well-known that REM sleep plays a pivotal role in the processing of salient and emotional waking-life experiences, strongly contributing to the emotional memory consolidation. Read More

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http://dx.doi.org/10.3389/fpsyg.2019.00459DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6428732PMC
March 2019
1 Read

Hypocretin-deficient narcolepsy patients have abnormal brain activation during humor processing.

Sleep 2019 Mar 29. Epub 2019 Mar 29.

Norwegian Centre of Expertise for Neurodevelopmental Disorders and Hypersomnias (NevSom), Department of Rare Disorders, Oslo University Hospital, Ullevål, Norway.

Study Objectives: To assess brain activation patterns in response to fun-rated and neutral-rated movies we performed functional magnetic resonance imaging (fMRI) during a humor-paradigm in narcolepsy type 1 (NT1) patients with cataplexy (muscle atonia triggered by emotions) and controls.

Methods: The fMRI-humor-paradigm consisted of short movies (25/30 with a humorous punchline; 5/30 without a humorous punchline (but with similar build-up/anticipation)) rated by participants based on their humor experience. We included 41 NT1 patients and 44 controls. Read More

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http://dx.doi.org/10.1093/sleep/zsz082DOI Listing
March 2019
1 Read

Participation of Dopamine D1 and D2 Receptors in the Rapid-Onset Behavioral Sensitization to Modafinil.

Front Pharmacol 2019 11;10:211. Epub 2019 Mar 11.

Laboratory of Neurophysiology, Department of Physiology, Universidade Federal de São Paulo, São Paulo, Brazil.

Studies on the abuse potential of modafinil, a psychostimulant-like drug used to treat narcolepsy, are still controversial. While some studies claim no potential for abuse, increasing evidence suggests that modafinil induces abuse-related effects, including rapid-onset behavioral sensitization (i.e. Read More

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http://dx.doi.org/10.3389/fphar.2019.00211DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6421293PMC
March 2019
1 Read

Factors Influencing Time to Diagnosis in Childhood Narcolepsy Type 1.

J Child Neurol 2019 Mar 27:883073819836548. Epub 2019 Mar 27.

1 School of Medicine, University of Glasgow, Glasgow, UK.

Objective:: To study the variables impacting on time from symptom onset to diagnosis in childhood narcolepsy, including presence of cataplexy, onset in infancy, administration of the H1N1 Pandemrix vaccine, and date of diagnosis following the H1N1 pandemic.

Design:: A retrospective cohort study of 42 children seen in a single tertiary pediatric neurology center between 1996 and 2016.

Key Results:: Onset of symptoms of narcolepsy occurred between infancy and 15 years, with 92. Read More

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http://dx.doi.org/10.1177/0883073819836548DOI Listing
March 2019
8 Reads

Cortical activation during sleep predicts dream experience in narcolepsy.

Ann Clin Transl Neurol 2019 Mar 1;6(3):445-455. Epub 2019 Feb 1.

Department of Psychology University of Rome "Sapienza" Rome Italy.

Objective: Narcolepsy type 1 widely affects the architecture of sleep with frequent fast transition to REM sleep at both nighttime and daytime sleep onset. The occurrence of repeated sleep onset REM periods over the Multiple Sleep Latency Test offers a unique opportunity to identify EEG patterns predictive of successful dream recall after short periods composed of only REM or NREM sleep. It also permits to disentangle state- from trait-like differences in dream recall, by using a within-subjects design. Read More

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http://dx.doi.org/10.1002/acn3.718DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6414482PMC
March 2019
1 Read

Toward the Mysteries of Sleep.

Keio J Med 2019 ;68(1):27

International Institute for Integrative Sleep Medicine (WPI-IIIS), University of Tsukuba, Tsukuba, Japan.

Although sleep is a ubiquitous behavior in animal species with well-developed central nervous systems, many aspects in the neurobiology of sleep remain mysterious. Our discovery of orexin, a hypothalamic neuropeptide involved in the maintenance of wakefulness, has triggered an intensive research examining the exact role of the orexinergic and other neural pathways in the regulation of sleep/wakefulness. The orexin receptor antagonist suvorexant, which specifically block the endogenous waking system, has been approved as a new drug to treat insomnia. Read More

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http://dx.doi.org/10.2302/kjm.68-001-ABSTDOI Listing
January 2019
1 Read

Control of the cardiovascular and respiratory systems during sleep.

Auton Neurosci 2019 May 30;218:54-63. Epub 2019 Jan 30.

Department of Neurology, Mayo Clinic, Rochester, MN, United States of America. Electronic address:

Sleep and arousal from sleep are associated with profound changes in cardiovascular and respiratory functions. Fluctuations of arterial blood pressure (ABP), heart rate (HR), and respiration occur both during non-rapid eye movement (NREM) and REM sleep and during transitions between sleep and behavioral arousal. These changes reflect complex, state-dependent interactions among several neuronal groups in the hypothalamus and brainstem. Read More

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http://dx.doi.org/10.1016/j.autneu.2019.01.007DOI Listing
May 2019
2 Reads

Knowledge Gaps in the Perioperative Management of Adults With Narcolepsy: A Call for Further Research.

Anesth Analg 2019 Mar 7. Epub 2019 Mar 7.

Division of Pulmonary, Critical Care and Sleep Medicine, Metro Health Medical Center, Case Western Reserve University, Cleveland, Ohio.

There is increasing awareness that sleep disorders may be associated with increased perioperative risk. The Society of Anesthesia and Sleep Medicine created the Narcolepsy Perioperative Task Force: (1) to investigate the current state of knowledge of the perioperative risk for patients with narcolepsy, (2) to determine the viability of developing perioperative guidelines for the management of patients with narcolepsy, and (3) to delineate future research goals and clinically relevant outcomes. The Narcolepsy Perioperative Task Force established that there is evidence for increased perioperative risk in patients with narcolepsy; however, this evidence is sparse and based on case reviews, case series, and retrospective reviews. Read More

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http://dx.doi.org/10.1213/ANE.0000000000004088DOI Listing
March 2019
4 Reads

A Pediatric Case of Narcolepsy Presenting as Syncope.

Cureus 2018 Dec 31;10(12):e3801. Epub 2018 Dec 31.

Internal Medicine, Jersey Shore University Medical Center, Neptune City, USA.

Narcolepsy is a chronic genetic and sleep disorder that is caused by a protein deficiency. This may affect the patients' sleep architecture and the brain's ability to control circadian rhythms. Individuals with this condition feel rested after waking but then feel tired and sleepy as the day progresses. Read More

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http://dx.doi.org/10.7759/cureus.3801DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6402730PMC
December 2018
1 Read

Measurement of symptoms in idiopathic hypersomnia: The Idiopathic Hypersomnia Severity Scale.

Neurology 2019 Apr 13;92(15):e1754-e1762. Epub 2019 Mar 13.

From Département de neurologie (Y.D., E.E., L.B., R.L., S.C., C.D., S.B.), Unité du Sommeil, Centre National de Référence pour la Narcolepsie et Hypersomnie rares Hôpital Gui-de-Chauliac, CHU Montpellier; and INSERM 1061 (Y.D., E.E., L.B., R.L., S.B., I.J.), University Montpellier, France.

Objective: To validate the Idiopathic Hypersomnia Severity Scale (IIHSS), a self-report measure of hypersomnolence symptoms, consequences, and responsiveness to treatment.

Methods: The 14-item IHSS (developed and validated by sleep experts with patients' feedback) was filled in by 218 participants (2.3% missing data). Read More

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http://dx.doi.org/10.1212/WNL.0000000000007264DOI Listing
April 2019
1 Read

43 Tinnitus as an Aura for Sleep Paralysis.

CNS Spectr 2019 Feb;24(1):199

4Smell and Taste Treatment and Research Foundation,Chicago,IL.

Objective: To understand that tinnitus may be an aura for sleep paralysis.

Background: Sleep paralysis is a transient-paralysis which occurs during awakening or falling asleep (Wilson, 1928). Those affected experience symptoms including visual, auditory, and haptic hallucinations, voluntary motor paralysis with intact ocular and respiratory motor movements, and diffuse or localized paresthesias. Read More

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http://dx.doi.org/10.1017/S1092852919000361DOI Listing
February 2019
4 Reads

Central Sleep Apnea With Sodium Oxybate in a Pediatric Patient.

Authors:
Arezou Heshmati

J Clin Sleep Med 2019 Mar 15;15(3):515-517. Epub 2019 Mar 15.

Columbia University Medical Center, New York, New York.

Abstract: A 12-year-old girl with normal neurodevelopment and narcolepsy type 1 presented with unexpected central apneas in response to sodium oxybate (SO). The patient underwent overnight polysomnography on SO (2.75 + 2. Read More

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http://dx.doi.org/10.5664/jcsm.7690DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6411192PMC
March 2019
2 Reads

Fluctuation of primary motor cortex excitability during cataplexy in narcolepsy.

Ann Clin Transl Neurol 2019 Feb 20;6(2):210-221. Epub 2019 Jan 20.

Department of Neurology Changzheng Hospital The Second Military Medical University Shanghai China.

Objective: Cataplexy is a complicated and dynamic process in narcolepsy type 1 (NT1) patients. This study aimed to clarify the distinct stages during a cataplectic attack and identify the changes of the primary motor cortex (PMC) excitability during these stages.

Methods: Thirty-five patients with NT1 and 29 healthy controls were recruited to this study. Read More

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http://doi.wiley.com/10.1002/acn3.670
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http://dx.doi.org/10.1002/acn3.670DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6389735PMC
February 2019
5 Reads

[Somatization].

Authors:
Rino Scuccato

Recenti Prog Med 2019 Feb;110(2):100-105

Neurologo libero professionista, Vicenza.

Functional disorders that we observe neurologically primarily pose terminology problems: some of them such as migraine, narcolepsy, restless legs syndrome have a recognized nosographic status, although without demonstrable lesions; others are interpreted only as somatic manifestations of psychic conflicts. There is also the risk that the "functional" diagnosis masks - as prejudice - lesional pathologies not adequately investigated with the available technology, leading to serious clinical errors. Moreover, even in presence of a probable psychogenic disorder, patients tend to reject the "functional" diagnosis, for cultural reasons linked to the old philosophical separation between diseases of the body and mind (the latter with a "lower" status). Read More

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http://dx.doi.org/10.1701/3112.31007DOI Listing
February 2019
1 Read

Antidepressants for the treatment of narcolepsy: A prospective study of 148 patients in northern China.

J Clin Neurosci 2019 May 2;63:27-31. Epub 2019 Mar 2.

Department of Neurology, Xijing Hospital, The Fourth Military Medical University, Xi'an, China. Electronic address:

Narcolepsy is a life-long neurological disorder characterized by excessive daytime sleepiness (EDS) and cataplexy. At present, Sodium oxybate, modafinil, methylphenidate and other stimulants are recommended first-line therapies for narcolepsy but are difficult to obtain in China. One hundred forty-eight patients with narcolepsy were treated with antidepressants and administered the Epworth Sleepiness Scale (ESS) and the Maintenance of Wakefulness Test (MWT) before and after treatment from August 2012 to August 2017. Read More

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http://dx.doi.org/10.1016/j.jocn.2019.02.014DOI Listing
May 2019
1 Read

Retraction statement: 'Hidden authority study data have come to light: besides narcolepsy the swine influenza vaccine Pandemrix caused type 1 diabetes'.

Authors:

J Intern Med 2018 Sep 2;284(3):328. Epub 2018 Jul 2.

The above letter to the editor written by "Lars Andersson" (stated to be affiliated with Department of Physiology and Pharmacology, Karolinska Institutet), published in print and online in the Journal of Internal Medicine in Wiley Online Library https://onlinelibrary.wiley.com) on the date given above, has been retracted by agreement between the journal's Editor-in-Chief Ulf de Faire, the Association for Publication of the Journal of Internal Medicine and John Wiley & Sons Limited. Read More

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http://dx.doi.org/10.1111/joim.12807DOI Listing
September 2018
1 Read

Retraction statement: Response on the author's reply to the Letter to the Editor: contradictory data on type 1 diabetes in a recently published article: 'Risks of neurological and immune-related diseases, including narcolepsy, after vaccination with Pandemrix'.

Authors:

J Intern Med 2018 Sep 2;284(3):329. Epub 2018 Jul 2.

The above letter to the editor written by "Lars Andersson" (stated to be affiliated with Department of Physiology and Pharmacology, Karolinska Institutet), published in print and online in the Journal of Internal Medicine in Wiley Online Library https://onlinelibrary.wiley.com) on the date given above, has been retracted by agreement between the journal's Editor-in-Chief Ulf de Faire, the Association for Publication of the Journal of Internal Medicine and John Wiley & Sons Limited. Read More

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http://dx.doi.org/10.1111/joim.12808DOI Listing
September 2018
1 Read

Retraction statement: Contradictory data on type 1 diabetes in a recently published article: 'Risks of neurological and immune-related diseases, including narcolepsy, after vaccination with Pandemrix: a population- and registry-based cohort study with over 2 years of follow-up' (JOIM 2013).

Authors:

J Intern Med 2018 Sep 2;284(3):330. Epub 2018 Jul 2.

The above letter to the editor written by "Lars Andersson" (stated to be affiliated with Department of Physiology and Pharmacology, Karolinska Institutet), published in print and online in the Journal of Internal Medicine in Wiley Online Library https://onlinelibrary.wiley.com) on the date given above, has been retracted by agreement between the journal's Editor-in-Chief Ulf de Faire, the Association for Publication of the Journal of Internal Medicine and John Wiley & Sons Limited. Read More

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http://dx.doi.org/10.1111/joim.12809DOI Listing
September 2018
1 Read

Monitoring of altered amino acid metabolic pattern in rat urine following intraperitoneal injection with γ-hydroxybutyric acid.

Metabolomics 2018 Aug 19;14(9):111. Epub 2018 Aug 19.

College of Pharmacy, Sunchon National University, Suncheon, 540-950, Republic of Korea.

Introduction: γ-Hydroxybutyric acid is a well-known prescription medicine that is used for the clinical treatment of alcohol dependence and narcolepsy. However, the biochemical mechanism underlying γ-hydroxybutyric acid intoxication remains unclear, and metabolomic amino acid profiling and pattern analyses have not been attempted following treatment with γ-hydroxybutyric acid.

Objectives: We carried out urinary amino acid profiling and pattern analyses in rats to determine the biochemical events associated with altered amino acid metabolism and biomarker detection of intoxication following treatment with γ-hydroxybutyric acid. Read More

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http://dx.doi.org/10.1007/s11306-018-1409-xDOI Listing
August 2018
1 Read

Medical specialty visits and diagnoses received by Saudi patients prior to a diagnosis of narcolepsy.

Sleep Breath 2019 Feb 28. Epub 2019 Feb 28.

Department of Medicine, College of Medicine, The University Sleep Disorders Center, King Saud University, Box 225503, Riyadh, 11324, Saudi Arabia.

Purpose: Narcolepsy is an uncommon neurological disorder characterized by excessive daytime sleepiness (EDS) and multiple other symptoms. Due to the under-recognition of narcolepsy symptoms, patients are often misdiagnosed. This study aimed to assess the types of specialties visited and the diagnoses received by Saudi patients prior to their narcolepsy diagnosis. Read More

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http://dx.doi.org/10.1007/s11325-019-01807-5DOI Listing
February 2019
1 Read

Narcolepsy - A Rare but under-recognized Problem in Children.

Indian Pediatr 2019 Feb;56(2):147

Institute of Pulmonology, Apollo Hospitals, Bengaluru, India.

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February 2019
1 Read

The role of home sleep testing for evaluation of patients with excessive daytime sleepiness: focus on obstructive sleep apnea and narcolepsy.

Sleep Med 2019 Jan 28. Epub 2019 Jan 28.

Yale Pulmonary and Critical Care Medicine, New Haven, CT, USA. Electronic address:

Excessive daytime sleepiness (EDS) is a common complaint in the general population, which may be associated with a wide range of sleep disorders and other medical conditions. Narcolepsy is a sleep disorder characterized primarily by EDS, which involves a substantial burden of illness but is often overlooked or misdiagnosed. In addition to identifying low cerebrospinal fluid (CSF) hypocretin (orexin) levels, evaluation for narcolepsy requires in-laboratory polysomnography (PSG). Read More

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http://dx.doi.org/10.1016/j.sleep.2019.01.014DOI Listing
January 2019
1 Read

Sleep-related disorders and their relationship with MRI findings in multiple sclerosis.

Sleep Med 2019 Jan 21. Epub 2019 Jan 21.

IRCCS San Raffaele Scientific Institute, Department of Clinical Neurosciences and Università Vita-Salute San Raffaele, Milan, Italy. Electronic address:

Sleep-related disorders have been reported to have a higher prevalence in multiple sclerosis (MS) than in the general population. They are often undervalued for the presence of more severe physical problems and the occurrence at night, without a direct observation in common clinical practice, but if not recognized and treated they can negatively affect the quality of life causing daytime drowsiness and worsening fatigue. Sleep related disorders most commonly reported in MS are as follows: insomnia, sleep-related breathing disorders (SRBD), restless legs syndrome (RLS) and periodic limb movement disorders (PLMD). Read More

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http://dx.doi.org/10.1016/j.sleep.2019.01.010DOI Listing
January 2019
15 Reads

SMPD1 mutations, activity, and α-synuclein accumulation in Parkinson's disease.

Mov Disord 2019 Apr 20;34(4):526-535. Epub 2019 Feb 20.

Montreal Neurological Institute, McGill University, Montréal, QC, Canada.

Background: SMPD1 (acid-sphingomyelinase) variants have been associated with Parkinson's disease in recent studies. The objective of this study was to further investigate the role of SMPD1 mutations in PD.

Methods: SMPD1 was sequenced in 3 cohorts (Israel Ashkenazi Jewish cohort, Montreal/Montpellier, and New York), including 1592 PD patients and 975 controls. Read More

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http://dx.doi.org/10.1002/mds.27642DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6469643PMC
April 2019
1 Read
5.680 Impact Factor

Demographic and nap-related variance of the MSLT: results from 2,498 suspected hypersomnia patients: Clinical MSLT variance.

Sleep Med 2019 Mar 30;55:115-123. Epub 2018 Dec 30.

SleepMed, Inc. Columbia, SC, USA; The University of South Carolina Medical School, Columbia, SC, USA; Bogan Sleep Consultants, LLC, Columbia, SC, USA.

Objective: The purpose of this study was to enhance our understanding of clinical trends in sleep and rapid eye movement (REM) propensity on the multiple sleep latency test (MSLT). Demographic variables of interest included early childhood/advanced age, gender, race, and REM-suppressant use.

Methods: Nocturnal sleep studies and 5-nap MSLTs were retrieved from a large repository of deidentified studies from various US sleep clinics between 2007 and 2015. Read More

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http://dx.doi.org/10.1016/j.sleep.2018.12.013DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6411434PMC

CD8 T cells from patients with narcolepsy and healthy controls recognize hypocretin neuron-specific antigens.

Nat Commun 2019 02 19;10(1):837. Epub 2019 Feb 19.

Department of Clinical Biochemistry, Molecular Sleep Laboratory, Rigshospitalet, 2600 Glostrup, Denmark.

Narcolepsy Type 1 (NT1) is a neurological sleep disorder, characterized by the loss of hypocretin/orexin signaling in the brain. Genetic, epidemiological and experimental data support the hypothesis that NT1 is a T-cell-mediated autoimmune disease targeting the hypocretin producing neurons. While autoreactive CD4 T cells have been detected in patients, CD8 T cells have only been examined to a minor extent. Read More

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http://dx.doi.org/10.1038/s41467-019-08774-1DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6381094PMC
February 2019
3 Reads

Finding a needle in the haystack-narcolepsy and obstructive sleep apnea.

Sleep Breath 2019 Feb 18. Epub 2019 Feb 18.

Departamento de Neurologia e Neurocirurgia, Universidade Federal de São Paulo, Rua Napoleão de Barros, 925 - 2° andar, Vila Clementino, São Paulo, 04024-002, Brazil.

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http://dx.doi.org/10.1007/s11325-019-01800-yDOI Listing
February 2019

A four year experience in narcolepsy from a sleep clinic at a tertiary care centre with a short review of contemporary Indian literature.

Indian J Med Res 2018 Dec;148(6):748-751

Department of Internal Medicine, All India Institute of Medical Sciences, New Delhi, India.

Narcolepsy is a common sleep disorder in Western countries but rarely reported from India. Here, we report a small case series of four narcolepsy patients seen over a four year period in the sleep clinic of a tertiary care hospital in north India. The diagnosis was established by clinical history and two or more sleep-onset rapid eye movements (SOREMs) on multiple sleep latency tests (MSLTs) following overnight polysomnography (PSG). Read More

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http://dx.doi.org/10.4103/ijmr.IJMR_888_16DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6396549PMC
December 2018
1 Read
1.661 Impact Factor

Pitolisant and intravenous cocaine self-administration in mice.

Eur J Pharmacol 2019 May 14;851:63-68. Epub 2019 Feb 14.

Département de Psychologie, Cognition et Comportement, Université de Liège, Place des Orateurs, 2/B-32, B-4000 Liège, Belgium.

Pitolisant, a selective inverse agonist for the histamine H3 receptor, is a new treatment for adults suffering from narcolepsy. Numerous studies have shown that striatal H3 receptors can modulate the activity of the dopamine mesolimbic system, a neuronal pathway that plays a crucial role in drug addiction. Therefore, it is important to guarantee that pitolisant has no abuse potential and does not potentiate the behavioral effects of psychostimulants. Read More

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https://linkinghub.elsevier.com/retrieve/pii/S00142999193010
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http://dx.doi.org/10.1016/j.ejphar.2019.02.019DOI Listing
May 2019
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Use and safety of nitrous oxide during lumbar puncture for the diagnosis of childhood narcolepsy.

Sleep Med 2018 Dec 18. Epub 2018 Dec 18.

IRCCS, Istituto delle Scienze Neurologiche di Bologna, Bologna, Italy; Department of Biomedical and Neuromotor Sciences (DIBINEM), University of Bologna, Bologna, Italy.

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http://dx.doi.org/10.1016/j.sleep.2018.12.003DOI Listing
December 2018
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Oral L-Carnitine used to treat narcoleptic type 1 patient during pregnancy - A case report.

Sleep Sci 2018 Jul-Aug;11(4):215-216

UNIFESP, Neurologia e Neurocirurgia - São Paulo - São Paulo - Brazil.

Narcolepsy type 1 is a sleep disorder characterized by excessive daytime sleepiness (EDS), sleep fragmentation, hypnagogic hallucinations, sleep paralysis, and cataplexy. Stimulant medications such as modafinil and amphetamines are the first-line medications for treating sleepiness. However, the management of narcolepsy during special circumstances of life such as pregnancy is complex. Read More

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http://dx.doi.org/10.5935/1984-0063.20180035DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6361304PMC
February 2019
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Night Stepping: Fitbit Cracks the Case.

J Clin Sleep Med 2019 Feb 15;15(2):355-357. Epub 2019 Feb 15.

Cleveland Clinic Sleep Disorders Center, Cleveland, Ohio.

Abstract: The most common sleep disorders that can result in injurious or violent behaviors include REM sleep behavioral disorder, sleepwalking, comorbid parasomnias, sleep-related dissociative disorder, and obstructive sleep apnea. Video polysomnography is usually indicated to evaluate recurring sleep-related injury in adults. Only one-third of patients with complex paroxysmal nocturnal events will have one of their habitual events on a single night of in-laboratory video polysomnography, most often those who have prominent, high-frequency motor features. Read More

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http://dx.doi.org/10.5664/jcsm.7646DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6374084PMC
February 2019
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Maintenance of Wakefulness Test, real and simulated driving in patients with narcolepsy/hypersomnia.

Sleep Med 2019 Mar 8;55:1-5. Epub 2018 Mar 8.

Université de Bordeaux, Sommeil, Attention et Neuropsychiatrie, USR 3413, Bordeaux, France; CNRS, SANPSY, USR 3413, Bordeaux, France; CHU Bordeaux, Centre Hypersomnies Rares, Bordeaux, France. Electronic address:

Study Objectives: To assess the relationship between real and simulated driving performance and the objective level of alertness as measured by the Maintenance of Wakefulness Test (MWT) in patients suffering from narcolepsy or idiopathic hypersomnia.

Methods: Twenty-seven patients (10 patients with narcolepsy, type 1 (n = 7) and type 2 (n = 3), and 17 patients with idiopathic hypersomnia, mean age = 33.8 ± 11. Read More

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http://dx.doi.org/10.1016/j.sleep.2018.02.009DOI Listing
March 2019
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Assessing readiness to drive in adolescents with narcolepsy: what are providers doing?

Sleep Breath 2019 Feb 8. Epub 2019 Feb 8.

Division of Pulmonary and Sleep Medicine, Children's Mercy Hospital, 2401 Gillham Rd, Kansas City, MO, 64108, USA.

Purpose: There are no universally accepted guidelines for assessing driving readiness in adolescents with narcolepsy. The purpose of the present study was to survey pediatric sleep medicine providers regarding their current practice patterns for assessing driving readiness in adolescents with narcolepsy, knowledge of their state laws regarding physician reporting of unsafe drivers, and opinions regarding what physician duty ought to be.

Methods: This was an anonymous web-based survey distributed via the PedSleep listserv, which serves as a hub of communication for pediatric sleep medicine providers. Read More

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http://dx.doi.org/10.1007/s11325-019-01799-2DOI Listing
February 2019
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Restless legs syndrome and iron deficiency in adults with attention deficit hyperactivity disorder.

Sleep 2019 Feb 5. Epub 2019 Feb 5.

National Reference Network for Narcolepsy, Department of Neurology, Hôpital Gui-de-Chauliac, CHU Montpellier, France.

Objective: The association between restless legs syndrome (RLS), periodic leg movements during sleep (PLMS) and iron deficiency has been reported in children with attention deficit/hyperactivity disorder (ADHD); however little is known in adults. The aim of this study was to assess frequencies of RLS, PLMS and other leg movements (LM) and iron deficiency and their relationships with ADHD phenotype in adults with ADHD.

Methods: 200 adults with ADHD (112 males, median age 31 years) were evaluated on lifetime ADHD symptoms and sleep characteristics. Read More

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http://dx.doi.org/10.1093/sleep/zsz027DOI Listing
February 2019
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Pandemrix-induced narcolepsy is associated with genes related to immunity and neuronal survival.

EBioMedicine 2019 Feb 30;40:595-604. Epub 2019 Jan 30.

Department of Medical Sciences, Clinical Pharmacology and Science for Life Laboratory, Uppsala University, Uppsala, Sweden.

Background: The incidence of narcolepsy rose sharply after the swine influenza A (H1N1) vaccination campaign with Pandemrix. Narcolepsy is an immune-related disorder with excessive daytime sleepiness. The most frequent form is strongly associated with HLA-DQB1*06:02, but only a minority of carriers develop narcolepsy. Read More

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https://linkinghub.elsevier.com/retrieve/pii/S23523964193004
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http://dx.doi.org/10.1016/j.ebiom.2019.01.041DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6413474PMC
February 2019
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A population-based and case-controlled study of children and adolescents with narcolepsy: Health-related quality of life, adaptive behavior and parental stress.

Eur J Paediatr Neurol 2019 Mar 19;23(2):288-295. Epub 2019 Jan 19.

Department of Pediatrics, Institute of Clinical Sciences, Sahlgrenska Academy at University of Gothenburg, Gothenburg, Sweden.

Objective: To investigate health-related quality of life (HrQoL) and adaptive behavior in young people with narcolepsy and stress among their parents.

Methods: In a cross-sectional exploratory quantitative study design, 37 young people with narcolepsy (8-20 years of age) and their parents were recruited. Thirty-one had post-H1N1 vaccination-related narcolepsy (PHV) and six had narcolepsy not related to PHV (nPHV). Read More

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http://dx.doi.org/10.1016/j.ejpn.2019.01.004DOI Listing
March 2019
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A randomized study of solriamfetol for excessive sleepiness in narcolepsy.

Ann Neurol 2019 Mar;85(3):359-370

Reference National Center for Narcolepsy-Hypersomnia, Guy de Chauliac Hospital, Montpellier University Hospital Center, National Institute of Health and Medical Research U1061, Montpellier, France.

Objective: Solriamfetol (JZP-110) is a selective dopamine and norepinephrine reuptake inhibitor with wake-promoting effects. This phase 3 study (NCT02348593) evaluated the safety and efficacy of solriamfetol in narcolepsy.

Methods: Patients with narcolepsy with mean sleep latency <25 minutes on the Maintenance of Wakefulness Test (MWT), Epworth Sleepiness Scale (ESS) score ≥10, and usual nightly sleep ≥6 hours were randomized to solriamfetol 75, 150, or 300 mg, or placebo for 12 weeks. Read More

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http://doi.wiley.com/10.1002/ana.25423
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http://dx.doi.org/10.1002/ana.25423DOI Listing
March 2019
17 Reads