86,454 results match your criteria Nanotechnology Science and Applications [Journal]


Mechanical properties of bovine erythrocytes derived from ion current measurements using micropipettes.

Bioelectrochemistry 2019 Apr 13;128:204-210. Epub 2019 Apr 13.

The MacDiarmid Institute for Advanced Materials and Nanotechnology, New Zealand; Department of Physics, The University of Auckland, New Zealand; School of Chemical Sciences, The University of Auckland, New Zealand. Electronic address:

Synchronized data from ion currents and optical microscopy have been used to measure the mechanical properties of individual soft microparticles. This new experimental method draws on the signals generated by each particle as it passes through the tip of a pipette. The technique represents an advance on micropipette aspiration (MA), which uses optical microscopy in isolation. Read More

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http://dx.doi.org/10.1016/j.bioelechem.2019.04.013DOI Listing

Superoxide dismutase in nanoarchaeosomes for targeted delivery to inflammatory macrophages.

Colloids Surf B Biointerfaces 2019 Mar 28;179:479-487. Epub 2019 Mar 28.

Nanomedicine Research & Development Center, Departamento de Ciencia y Tecnología, Universidad Nacional de Quilmes, Roque Saenz Peña 352, Bernal, B1876BXD, Argentina. Electronic address:

Oxidative stress plays an essential role in the pathogenesis and progression of inflammatory bowel disease. Co-administration of antioxidants and anti-inflammatory drugs has shown clinical benefits. Due to its significant reactive oxygen species (ROS) scavenging ability, great interest has been focused on superoxide dismutase (SOD) for therapeutic use. Read More

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https://linkinghub.elsevier.com/retrieve/pii/S09277765193021
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http://dx.doi.org/10.1016/j.colsurfb.2019.03.061DOI Listing
March 2019
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Susceptibility of Pseudomonas aeruginosa and antimicrobial activity using PK/PD analysis: an 18-year surveillance study.

Enferm Infecc Microbiol Clin 2019 Apr 17. Epub 2019 Apr 17.

Pharmacokinetic, Nanotechnology and Gene Therapy Group (PharmaNanoGene), Faculty of Pharmacy, Centro de investigación Lascaray ikergunea, University of the Basque Country UPV/EHU, Paseo de la Universidad 7, 01006 Vitoria-Gasteiz, Spain. Electronic address:

Introduction: We analysed the changes in the susceptibility of Pseudomonas aeruginosa to antimicrobials over an 18-year period (2000-2017) in order to evaluate the adequacy of the antimicrobial therapy against this organism in patients admitted in a tertiary Spanish hospital (excluding the intensive care unit). In addition, the antimicrobial activity was evaluated using pharmacokinetic/pharmacodynamic (PK/PD) criteria as a microbiological surveillance tool.

Methods: Susceptibility was studied according to the Clinical and Laboratory Standards Institute breakpoints. Read More

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https://linkinghub.elsevier.com/retrieve/pii/S0213005X193014
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http://dx.doi.org/10.1016/j.eimc.2019.02.009DOI Listing
April 2019
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Direct quantification of cancerous exosomes via surface plasmon resonance with dual gold nanoparticle-assisted signal amplification.

Biosens Bioelectron 2019 Apr 13;135:129-136. Epub 2019 Apr 13.

State Key Laboratory of Chemo/Biosensing and Chemometrics, College of Chemistry and Chemical Engineering, Key Laboratory for Bio-Nanotechnology and Molecular Engineering of Hunan Province, Hunan University, Changsha, 410082, China. Electronic address:

Sensitive detection of cancerous exosomes is critical to early diseases diagnosis and prognosis. Herein, a sensitive aptasensor was demonstrated for exosomes detection by surface plasmon resonance (SPR) with dual gold nanoparticle (AuNP)-assisted signal amplification. Dual nanoparticle amplification was achieved by controlled hybridization attachment of AuNPs resulting from electronic coupling between the Au film and AuNPs, as well as coupling effects in plasmonic nanostructures. Read More

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http://dx.doi.org/10.1016/j.bios.2019.04.013DOI Listing

Calcium Carbonate: Adored and Ignored in Bioactivity Assessment.

Acta Biomater 2019 Apr 17. Epub 2019 Apr 17.

Unit of Dental Physical Sciences, Barts and The London School of Medicine and Dentistry, Queen Mary University of London, Mile End Road, London E1 4NS, United Kingdom.

The title of this article could sound a bit curious to some readers since a layer of apatite - and not calcium carbonate - is well-known to form on the surface of bioactive glasses upon immersion in simulated body fluids. However, calcium carbonate (commonly reported as calcite crystals) can form on the surface of bioactive glasses as well, instead of or in competition with hydroxyapatite, during in vitro tests. Major factors that govern calcium carbonate formation are a high concentration of Ca ions in the testing solution - and, in this regard, glass composition/texture and type of medium play key roles - along with the volume of solution used during in vitro tests. Read More

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https://linkinghub.elsevier.com/retrieve/pii/S17427061193028
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http://dx.doi.org/10.1016/j.actbio.2019.04.039DOI Listing
April 2019
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Nanoemulsion strategy of pioglitazone for the treatment of skin inflammatory diseases.

Nanomedicine 2019 Apr 17. Epub 2019 Apr 17.

Institute of Nanoscience and Nanotechnology (IN2UB), University of Barcelona, 08028 Barcelona, Spain; Department of Pharmacy and Pharmaceutical Technology, Faculty of Pharmacy, University of Granada, Granada, Spain. Electronic address:

Pioglitazone (PGZ) is a peroxisome proliferator-activated receptor agonist. Its role in the inflammatory response modulation opens the door for additional therapeutic applications. The purpose of this study was to develop a pioglitazone nanoemulsion (PGZ-NE) to investigate its anti-inflammatory efficacy on the skin. Read More

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https://linkinghub.elsevier.com/retrieve/pii/S15499634193007
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http://dx.doi.org/10.1016/j.nano.2019.03.017DOI Listing
April 2019
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Bio-assay: The best alternative for conventional methods in detection of epidermal growth factor.

Int J Biol Macromol 2019 Apr 17. Epub 2019 Apr 17.

Nanotechnology Research Center, Uremia University, Uremia, Iran.

Growth factors are necessary for proper and efficient wound closure and tissue regeneration. Epidermal growth factor (EGF) is one of the key signaling molecules in stimulating epithelial cell motility, making it a required factor for re-epithelialization. Increased EGF expression is likely to be a strong prognostic and predictive feature in multiple tumor types and determination of EGF may product remarkable diagnosis benefits. Read More

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https://linkinghub.elsevier.com/retrieve/pii/S01418130193085
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http://dx.doi.org/10.1016/j.ijbiomac.2019.04.121DOI Listing
April 2019
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Tragacanth gum based hydrogel nanocomposites for the adsorption of methylene blue: Comparison of linear and non-linear forms of different adsorption isotherm and kinetics models.

Int J Biol Macromol 2019 Apr 17. Epub 2019 Apr 17.

Chemistry group, Pardis College, Isfahan University of Technology, Isfahan 84156-83111, Islamic Republic of Iran.

In the current work, novel eco-friendly hydrogel nanocomposite biosorbents (ef-HNCs) made up from tragacanth gum and modified CaCO nanoparticles (CC NPs) were applied for the adsorption of methylene blue dye (MBD). A simple, fast, and safe method regarding green chemistry was used to prepare the ef-HNC, with the aid of ultrasound waves. The ef-HNCs were successfully characterized using several spectroscopic, microscopic, and analytical methods. Read More

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https://linkinghub.elsevier.com/retrieve/pii/S01418130193103
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http://dx.doi.org/10.1016/j.ijbiomac.2019.04.129DOI Listing
April 2019
1 Read

Investigating the formulation of alginate- gelatin encapsulated Pseudomonas fluorescens (VUPF5 and T17-4 strains) for controlling Fusarium solani on potato.

Int J Biol Macromol 2019 Apr 17. Epub 2019 Apr 17.

Department of Plant Protection, Faculty of Agriculture, Vali-e-Asr University of Rafsanjan, Iran.

Nanotechnology is one of the most fascinating sciences with a great potential to improve many agricultural products. Use of nanoparticles in plant disease management is a novel area which may prove very effective in future. Use of nanomaterials and biocompatible compounds in nano-encapsulation of antagonist bacteria is an important step in enhancing the efficiency of these agents in adverse environmental conditions. Read More

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http://dx.doi.org/10.1016/j.ijbiomac.2019.04.071DOI Listing

Experimental Protocol for Culture and Differentiation of Osteoblasts on 3D Abode Using Nanofiber Scaffolds.

Methods Mol Biol 2019 Apr 20. Epub 2019 Apr 20.

Department of Nanotechnology, University of Kashmir, Srinagar, Jammu and Kashmir, India.

Nanofibrous structures provide a three-dimensional topography in vivo to allow the attachment, migration, proliferation, and differentiation of the cells in an environment which exactly mimics the native tissue. Herein, we report the standard protocols to carry out the cell culture of human osteoblast on nanofiber scaffolds. We also have described protocols for the determination of cell viability, morphology, mineralization, and phenotypic characterization of the osteoblasts. Read More

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http://link.springer.com/10.1007/7651_2019_230
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http://dx.doi.org/10.1007/7651_2019_230DOI Listing
April 2019
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Prenylated Rab acceptor RABAC1 inhibits anti-apoptotic protein BCL2A1 and induces apoptosis.

Biochem Biophys Res Commun 2019 Apr 16. Epub 2019 Apr 16.

Immunotherapy Research Center, Korea Research Institute of Bioscience and Biotechnology, Daejeon, Republic of Korea; Department of Biomolecular Science, University of Science and Technology, Daejeon, Republic of Korea. Electronic address:

The B cell lymphoma 2 (BCL2) family of proteins constitutes a critical intracellular checkpoint in the intrinsic apoptosis pathway. Among BCL2 members, the anti-apoptotic protein BCL2A1 mediates the resistance to BCL2 inhibitors and may be considered as a target for anti-cancer therapy. Here, we report that prenylated Rab acceptor 1 (RABAC1 or PRA1) inhibits the anti-apoptotic activity of BCL2A1 and induces apoptosis in AGS gastric cancer cells. Read More

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https://linkinghub.elsevier.com/retrieve/pii/S0006291X193071
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http://dx.doi.org/10.1016/j.bbrc.2019.04.080DOI Listing
April 2019
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Single-molecule nanomechanical spectroscopy shows calcium ions contribute to chain association and structural flexibility of blood clotting factor VIII.

Biochem Biophys Res Commun 2019 Apr 16. Epub 2019 Apr 16.

CAS Key Laboratory of Interfacial Physics and Technology, Shanghai Institute of Applied Physics, Chinese Academy of Sciences, Shanghai, 201800, China; ZhangJiang Lab, Shanghai Synchrotron Radiation Facility, Shanghai Advanced Research Institute, Chinese Academy of Sciences, Shanghai, 201210, China. Electronic address:

Blood coagulation factor VIII (FVIII) can bind calcium ions and ion-protein interactions appear central importance for both their structure and function in coagulation cascade. However, the mechanism and details of how calcium dependent structure change of proteins to fulfill their function remain to be fully defined. In this work, PeakForce Quantitative Nanomechanics (PF-QNM) mode atomic force microscopy (AFM) was used to map the topography and mechanical properties of FVIII with single protein resolution under different calcium concentrations. Read More

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http://dx.doi.org/10.1016/j.bbrc.2019.04.068DOI Listing

Theoretical Importance of PVP-Alginate Hydrogels Structure on Drug Release Kinetics.

Gels 2019 Apr 18;5(2). Epub 2019 Apr 18.

Department of Engineering and Architecture, Trieste University, via Valerio 6, I-34127 Trieste, Italy.

Background: The new concepts of personalized and precision medicine require the design of more and more refined delivery systems. In this frame, hydrogels can play a very important role as they represent the best surrogate of soft living tissues for what concerns rheological properties. Thus, this paper focusses on a global theoretical approach able to describe how hydrogel polymeric networks can affect the release kinetics of drugs characterized by different sizes. Read More

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http://dx.doi.org/10.3390/gels5020022DOI Listing
April 2019
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MMP-9 Downregulation with Lipid Nanoparticles for Inhibiting Corneal Neovascularization by Gene Silencing.

Nanomaterials (Basel) 2019 Apr 18;9(4). Epub 2019 Apr 18.

Pharmacokinetic, Nanotechnology & Gene Therapy Group (PharmaNanoGene), Faculty of Pharmacy, Centro de investigación Lascaray ikergunea, University of the Basque Country UPV/EHU, Paseo de la Universidad 7, 01015 Vitoria-Gasteiz, Spain.

Gene silencing targeting proangiogenic factors have been shown to be a useful strategy in the treatment of corneal neovascularization (CNV). Among interference RNA (RNAi) molecules, short-hairpin RNA (shRNA) is a plasmid-coded RNA able to down-regulate the expression of the desired gene. It is continuously produced in the host cell, inducing a durable gene silencing effect. Read More

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https://www.mdpi.com/2079-4991/9/4/631
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http://dx.doi.org/10.3390/nano9040631DOI Listing
April 2019
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Impact of mercury speciation on its removal from water by activated carbon and organoclay.

Water Res 2019 Apr 9;157:600-609. Epub 2019 Apr 9.

Carnegie Mellon University, Pittsburgh, PA, 15213, United States; Center for Environmental Implications of Nanotechnology, Pittsburgh, PA, 15213, United States. Electronic address:

Mercury (Hg) speciation can affect its removal efficiency by adsorbents. This study assessed the removal of dissolved inorganic Hg(II) species (Hg(II)*), β-HgS nanoparticles (HgS NP), and Hg complexed with dissolved organic matter (Hg-DOM) by three sorbents: activated carbon (AC), sulfur-impregnated activated carbon (SAC), and organoclay (OC). The effect of ionic composition, solution ionic strength, and natural organic matter (NOM) concentration on the removal of each Hg species was also evaluated. Read More

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https://linkinghub.elsevier.com/retrieve/pii/S00431354193031
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http://dx.doi.org/10.1016/j.watres.2019.04.006DOI Listing
April 2019
3 Reads

Multilayer nanoscale functionalisation to treat disorders and enhance regeneration of bone tissue.

Nanomedicine 2019 Apr 16. Epub 2019 Apr 16.

School of Engineering, Newcastle University, Claremont Road, Newcastle upon Tyne NE1 7RU, United Kingdom. Electronic address:

The coatings application onto medical devices has experienced a continuous growth in the last few years. Medical device coating market is expected to grow at a CAGR of 5.16% to reach USD 10 million by 2023 due to the increasing geriatric population and the growing demand for continuous innovation. Read More

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http://dx.doi.org/10.1016/j.nano.2019.03.009DOI Listing

New folate receptor targeted nano liposomes for delivery of 5-fluorouracil to cancer cells: Strong implication for enhanced potency and safety.

Life Sci 2019 Apr 16. Epub 2019 Apr 16.

Department of Toxicology, Faculty of Medical Sciences, Tarbiat Modares University, Tehran, Iran. Electronic address:

We previously showed that folate liposomes of 5FU made from Dipalmitoylphosphatidylcholine (DPPC) induced cell death in HT-29 and HeLa cells more potently than bulk 5FU. Also, a primary 5FU liposomal formulation with phosphatidyl choline (PC) exhibited higher cytotoxicity in murine colon cancer cells. In the present study, optimization of 5FU PC liposome, mechanism of cell death induction in human cancer cell lines and its safety along with other assays have been employed for targeted PC liposomes of 5FU. Read More

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http://dx.doi.org/10.1016/j.lfs.2019.04.030DOI Listing

Nanocrystalline cellulose: Preparation, physicochemical properties, and applications in drug delivery systems.

Int J Biol Macromol 2019 Apr 16. Epub 2019 Apr 16.

Immunology Research Center, Tabriz University of Medical Sciences, Tabriz, Iran. Electronic address:

Cancer is the leading cause of death all over the world and chemotherapy is an important approach to fight cancer, however, there are many obstacles against successful cancer chemotherapy such as development of multidrug resistance, poor solubility of chemotherapeutic agents and adverse side effects to healthy tissues. An important strategy to overcome these obstacles, is the use of nanotechnology. In recent years, natural polymers such as cellulose and its nanoform structure, nanocrystalline cellulose (NCC), have attracted the interest of researchers in the field of nanotechnology and specially drug delivery systems, due to biocompatibility and biodegradability of NCC. Read More

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https://linkinghub.elsevier.com/retrieve/pii/S01418130193169
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http://dx.doi.org/10.1016/j.ijbiomac.2019.04.117DOI Listing
April 2019
2 Reads

Two-component cross-linkable gels for fabrication of solid oral dosage forms.

J Control Release 2019 Apr 16. Epub 2019 Apr 16.

Faculty of Biotechnology and Food Engineering, Technion - Israel Institute of Technology, Haifa 3200003, Israel; Russell Berrie Nanotechnology Institute, Technion - Israel Institute of Technology, Haifa 3200003, Israel.

Current three-dimensional (3D) printing techniques involve the solidification of the injected materials by means of UV irradiation, evaporation of organic solvents, or harsh heating and cooling processes. These methods limit the printing of many sensitive bio-active molecules such as proteins. We describe a novel 3D printing technique based on two complementary liquid copolymers, PEG-PCL-SC and PEG-PCL-NH, that are injected in a coordinated fashion and react with each other to form a pre-designed 3D pill. Read More

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https://linkinghub.elsevier.com/retrieve/pii/S01683659193022
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http://dx.doi.org/10.1016/j.jconrel.2019.04.021DOI Listing
April 2019
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Oral delivery of nanoparticles - let's not forget about the protein corona.

Expert Opin Drug Deliv 2019 Apr 19. Epub 2019 Apr 19.

b Laboratory of Supramolecular and BioNano Materials (SupraBioNanoLab), Department of Chemistry , Materials and Chemical Engineering , Politecnico di Milano, Milano , Italy.

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http://dx.doi.org/10.1080/17425247.2019.1610384DOI Listing
April 2019
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Identification of the A293 (AVE1231) Binding Site in the Cardiac Two-Pore-Domain Potassium Channel TASK-1: a Common Low Affinity Antiarrhythmic Drug Binding Site.

Cell Physiol Biochem 2019 ;52(5):1223-1235

Department of Cardiology, University of Heidelberg, Heidelberg, Germany.

Background/aims: The two-pore-domain potassium channel TASK-1 regulates atrial action potential duration. Due to the atrium-specific expression of TASK-1 in the human heart and the functional upregulation of TASK-1 currents in atrial fibrillation (AF), TASK-1 represents a promising target for the treatment of AF. Therefore, detailed knowledge of the molecular determinants of TASK-1 inhibition may help to identify new drugs for the future therapy of AF. Read More

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https://www.cellphysiolbiochem.com/Articles/000083/
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http://dx.doi.org/10.33594/000000083DOI Listing
January 2019
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Leptothoe, a new genus of marine cyanobacteria (Synechococcales) and three new species associated with sponges from the Aegean Sea.

J Phycol 2019 Apr 18. Epub 2019 Apr 18.

Department of Botany, School of Biology, Aristotle University of Thessaloniki, GR-541 24, Thessaloniki, Greece.

Cyanobacterial diversity associated with sponges remains underestimated, though it is of great scientific interest in order to understand the ecology and evolutionary history of the symbiotic relationships between the two groups. Of the filamentous cyanobacteria, the genus Leptolyngbya is the most frequently found in association with sponges as well as the largest and obviously polyphyletic group. In this study, five Leptolyngbya-like sponge-associated isolates were investigated using a combination of molecular, chemical, and morphological approach and revealed a novel marine genus herein designated Leptothoe gen. Read More

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http://dx.doi.org/10.1111/jpy.12866DOI Listing

Tuning phonon transport spectrum for better thermoelectric materials.

Sci Technol Adv Mater 2019 21;20(1):10-25. Epub 2018 Dec 21.

Department of Mechanical Engineering, The University of Tokyo, Tokyo, Japan.

The figure of merit of thermoelectric materials can be increased by suppressing the lattice thermal conductivity without degrading electrical properties. Phonons are the carriers for lattice thermal conduction, and their transport can be impeded by nanostructuring, owing to the recent progress in nanotechnology. The key question for further improvement of thermoelectric materials is how to realize ultimate structure with minimum lattice thermal conductivity. Read More

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http://dx.doi.org/10.1080/14686996.2018.1548884DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6454406PMC
December 2018

Zinc-Doped Copper Oxide Nanocomposites Inhibit the Growth of Pancreatic Cancer by Inducing Autophagy Through AMPK/mTOR Pathway.

Front Pharmacol 2019 2;10:319. Epub 2019 Apr 2.

Department of Pharmacology, School of Basic Medical Sciences, Capital Medical University, Beijing, China.

Zinc doped copper oxide nanocomposites (Zn-CuO NPs) is a novel doped metal nanomaterial synthesized by our group using the sonochemical method. Our previous studies have shown that Zn-CuO NPs could inhibit cancer cell proliferation by inducing apoptosis via ROS-mediated pathway. In the present study, we studied the anticancer effect of Zn-CuO NPs on human pancreatic cancer cells. Read More

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https://www.frontiersin.org/article/10.3389/fphar.2019.00319
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http://dx.doi.org/10.3389/fphar.2019.00319DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6454023PMC
April 2019
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Liposomes loaded with phenolic extracts of Spirulina LEB-18: Physicochemical characterization and behavior under simulated gastrointestinal conditions.

Food Res Int 2019 Jun 14;120:656-667. Epub 2018 Nov 14.

Centro de Engenharia Biológica, Universidade do Minho, Campus de Gualtar, Braga 4710-057, Portugal; INL - International Iberian Nanotechnology Laboratory, Av. Mestre José Veiga, Braga 4715-330, Portugal. Electronic address:

Liposomes composed of rice (RL) and soybean (SL) lecithins were produced by reverse phase evaporation and used for the encapsulation of phenolic extracts from Spirulina LEB-18 (S-RL and S-SL for liposomes of rice and soybean lechitin, respectively). Liposomes were characterized in terms of size distribution, polydispersity index, and ζ-potential; the chemical interactions between the phenolic compounds from Spirulina and liposomes were evaluated by Fourier Transform Infrared Spectroscopy (FTIR), and X-ray diffraction (XRD) and differential scanning calorimetry (DSC) were used to evaluate their crystallinity pattern. The release behavior of phenolic extracts was evaluated under two different pH conditions. Read More

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http://dx.doi.org/10.1016/j.foodres.2018.11.023DOI Listing

Nanoemulsion-based delivery systems for testing nutraceutical efficacy using Caenorhabditis elegans: Demonstration of curcumin bioaccumulation and body-fat reduction.

Food Res Int 2019 Jun 20;120:157-166. Epub 2019 Feb 20.

Department of Food Science, University of Massachusetts Amherst, Amherst, MA 01003, USA. Electronic address:

The genome of the nematode Caenorhabditis elegans shares many similarities with that of humans and so it is widely used as a model in pharmaceutical and nutritional studies. C. elegans has a small mouth and therefore very fine lipid particles are required to orally deliver hydrophobic nutraceuticals. Read More

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https://linkinghub.elsevier.com/retrieve/pii/S09639969193012
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http://dx.doi.org/10.1016/j.foodres.2019.02.036DOI Listing
June 2019
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Non-conventional compounds with potential therapeutic effects against Alzheimer's disease.

Expert Rev Neurother 2019 Apr 19. Epub 2019 Apr 19.

a Laboratory of Molecular Modeling, Department of Chemistry , Federal University of Lavras , Lavras/MG , 37200-000 , Brazil.

Introduction: Alzheimer's disease (AD) is the most common cause of dementia. Clinical progress in this pathogenesis field has drawn the attention of researchers, stimulating the investigation of novel treatment methods. Current therapies that deal with cholinesterase inhibitors and/or NMDA antagonists have shown a modest symptomatic potential, increasing the need for research into more efficient therapeutics. Read More

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http://dx.doi.org/10.1080/14737175.2019.1608823DOI Listing
April 2019
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Self-Assembly of Metal Nanoclusters for Aggregation-Induced Emission.

Int J Mol Sci 2019 Apr 17;20(8). Epub 2019 Apr 17.

Beijing Advanced Innovation Center of Materials Genome Engineering, Research Center for Bioengineering and Sensing Technology, School of Chemistry and Biological Engineering, University of Science and Technology Beijing, Beijing 100083, China.

Aggregation-induced emission (AIE) is an intriguing strategy to enhance the luminescence of metal nanoclusters (NCs). However, the morphologies of aggregated NCs are often irregular and inhomogeneous, leading to instability and poor color purity of the aggregations, which greatly limit their further potential in optical applications. Inspired by self-assembly techniques, manipulating metal NCs into well-defined architectures has achieved success. Read More

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https://www.mdpi.com/1422-0067/20/8/1891
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http://dx.doi.org/10.3390/ijms20081891DOI Listing
April 2019
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Theoretical foundation of detrending methods for fluctuation analysis such as detrended fluctuation analysis and detrending moving average.

Phys Rev E 2019 Mar;99(3-1):033305

Max Planck Institute for the Physics of Complex Systems, Nöthnitzer Straße 38, 01187 Dresden, Germany.

We present a bottom-up derivation of fluctuation analysis with detrending for the detection of long-range correlations in the presence of additive trends or intrinsic nonstationarities. While the well-known detrended fluctuation analysis (DFA) and detrending moving average (DMA) were introduced ad hoc, we claim basic principles for such methods where DFA and DMA are then shown to be specific realizations. The mean-squared displacement of the summed time series contains the same information about long-range correlations as the autocorrelation function but has much better statistical properties for large time lags. Read More

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https://link.aps.org/doi/10.1103/PhysRevE.99.033305
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http://dx.doi.org/10.1103/PhysRevE.99.033305DOI Listing
March 2019
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Criticality in failure under compression: Acoustic emission study of coal and charcoal with different microstructures.

Phys Rev E 2019 Mar;99(3-1):033001

Departament de Física de la Matèria Condensada, Facultat de Física, Universitat de Barcelona, Martí i Franquès 1, 08028 Barcelona, Catalonia, Spain.

A systematic study of acoustic emission avalanches in coal and charcoal samples under slow uniaxial compression is presented. The samples exhibit a range of organic composition in terms of chemical elements as well as different degrees of heterogeneity in the microstructure. The experimental analysis focuses on the energies E of the individual acoustic emission events as well as on the time correlations between successive events. Read More

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http://dx.doi.org/10.1103/PhysRevE.99.033001DOI Listing

Exposure effects of endotoxin-free titanium-based wear particles to human osteoblasts.

J Mech Behav Biomed Mater 2019 Apr 10;95:143-152. Epub 2019 Apr 10.

Department of Physics, UNESP, São Paulo State University, 17033-360, Bauru, SP, Brazil.

Titanium-based materials are widely employed by the biomedical industry in orthopedic and dental implants. However, when placed into the human body, these materials are highly susceptible to degradation processes, such as corrosion, wear, and tribocorrosion. As a consequence, metallic ions or particles (debris) may be released, and although several studies have been conducted in recent years to better understand the effects of their exposure to living cells, a consensual opinion has not yet been obtained. Read More

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https://linkinghub.elsevier.com/retrieve/pii/S17516161193028
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http://dx.doi.org/10.1016/j.jmbbm.2019.04.003DOI Listing
April 2019
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Immunohistochemical analysis of retraction pocket pars tensa of tympanic membrane in children.

Int J Pediatr Otorhinolaryngol 2019 Apr 11;122:111-116. Epub 2019 Apr 11.

Department of Pediatrics, University Hospital Brno and Faculty of Medicine, Masaryk University Brno, Brno, Czech Republic.

Aims: Immunohistochemical analysis of retraction pocket pars tensa of tympanic membrane in children. Identification of signs typical for cholesteatoma and support of retraction theory of cholesteatoma.

Study Design: a prospective study analysing 31 surgically removed retraction pockets. Read More

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https://linkinghub.elsevier.com/retrieve/pii/S01655876193017
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http://dx.doi.org/10.1016/j.ijporl.2019.04.008DOI Listing
April 2019
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Current status of nanomaterial-based treatment for hepatocellular carcinoma.

Biomed Pharmacother 2019 Apr 15;116:108852. Epub 2019 Apr 15.

Departments of Biology, UAE University, Al Ain, United Arab Emirates. Electronic address:

Cancer continues to be the leading cause of death worldwide. Hepatocellular carcinoma (HCC), a prominent form of liver cancer, is the second leading cause of cancer-related deaths, thanks to the lack of efficient diagnostic tools and consequently late diagnosis and to the scarce of available suitable treatments. Thus, novel approaches to treat HCC are in demand. Read More

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https://linkinghub.elsevier.com/retrieve/pii/S07533322183881
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http://dx.doi.org/10.1016/j.biopha.2019.108852DOI Listing
April 2019
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MPL nano-liposomal vaccine containing P5 HER2/neu-derived peptide pulsed PADRE as an effective vaccine in a mice TUBO model of breast cancer.

J Control Release 2019 Apr 15. Epub 2019 Apr 15.

Biotechnology Research Center, Pharmaceutical Technology Institute, Mashhad University of Medical Sciences, Mashhad, Iran; Department of Pharmaceutical Nanotechnology, School of Pharmacy, Mashhad University of Medical Sciences, Mashhad, Iran. Electronic address:

Liposomal peptide-based vaccines can potentially suppress cancer cells proliferation in the host. To enhance the effectiveness of vaccination against cancer, additional strategies should also be employed. One strategy to promote peptide-based vaccine efficacy and induce powerful immune responses, is simultaneous activation of CD4 and CD8 T cells. Read More

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http://dx.doi.org/10.1016/j.jconrel.2019.04.019DOI Listing
April 2019
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Quantitative atomic force microscopy provides new insight into matrix vesicle mineralization.

Arch Biochem Biophys 2019 Apr 15. Epub 2019 Apr 15.

Nanoscience & Nanotechnology & Innovative Instrumentation (NAST) Centre, University of Rome Tor Vergata, Rome, Italy; Department of Experimental Medicine, University of Rome Tor Vergata, Rome, Italy; Sanford Burnham Prebys Medical Discovery Institute, La Jolla, CA, 92037, USA. Electronic address:

Matrix vesicles (MVs) are a class of extracellular vesicles that initiate mineralization in cartilage, bone, and other vertebrate tissues by accumulating calcium ions (Ca) and inorganic phosphate (P) within their lumen and forming a nucleation core (NC). After further sequestration of Ca and P, the NC transforms into crystalline complexes. Direct evidence of the existence of the NC and its maturation have been provided solely by analyses of dried samples. Read More

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https://linkinghub.elsevier.com/retrieve/pii/S00039861183104
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http://dx.doi.org/10.1016/j.abb.2019.04.003DOI Listing
April 2019
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Circulating Endothelial Cells From Septic Shock Patients Convert to Fibroblasts Are Associated With the Resuscitation Fluid Dose and Are Biomarkers for Survival Prediction.

Crit Care Med 2019 Apr 15. Epub 2019 Apr 15.

Departamento de Ciencias Biologicas, Facultad de Ciencias de la Vida, Universidad Andres Bello, Santiago, Chile.

Objectives: To determine whether circulating endothelial cells from septic shock patients and from nonseptic shock patients are transformed in activated fibroblast by changing the expression level of endothelial and fibrotic proteins, whether the level of the protein expression change is associated with the amount of administered resuscitation fluid, and whether this circulating endothelial cell protein expression change is a biomarker to predict sepsis survival.

Design: Prospective study.

Setting: Medical-surgical ICUs in a tertiary care hospital. Read More

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http://dx.doi.org/10.1097/CCM.0000000000003778DOI Listing

Surface Functionalization of Grown-on-Tip ZnO Nanopyramids: From Fabrication to Light-Triggered Applications.

ACS Appl Mater Interfaces 2019 Apr 18. Epub 2019 Apr 18.

CNR-ICMATE and INSTM, Department of Chemical Sciences , Padova University , 35131 Padova , Italy.

We report on a combined chemical vapor deposition (CVD)/radio frequency (RF) sputtering synthetic strategy for the controlled surface modification of ZnO nanostructures by Ti-containing species. Specifically, the proposed approach consists in the CVD of grown-on-tip ZnO nanopyramids, followed by titanium RF sputtering under mild conditions. The results obtained by a thorough characterization demonstrate the successful ZnO surface functionalization with dispersed Ti-containing species in low amounts. Read More

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http://pubs.acs.org/doi/10.1021/acsami.8b22744
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http://dx.doi.org/10.1021/acsami.8b22744DOI Listing
April 2019
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Isolation and characterization of a novel scFv antibody fragments specific for Hsp70 as a tumor biomarker.

J Cell Biochem 2019 Apr 18. Epub 2019 Apr 18.

Drug Applied Research Center, Tabriz University of Medical Sciences, Tabriz, Iran.

Many studies have shown that more than 50% of tumors express heat shock protein 70 kDa (Hsp70) at the plasma membrane surface while not seen in normal cells, therefore it is a promising therapeutic target in human cancers. Hence, we used phage display technology to produce a single-chain fragment variable (scFv) antibody against human Hsp70. For this, a target peptide from human Hsp70 was designed using bioinformatics studies and was chemically synthesized. Read More

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https://onlinelibrary.wiley.com/doi/abs/10.1002/jcb.28732
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http://dx.doi.org/10.1002/jcb.28732DOI Listing
April 2019
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TPP1 Delivery to Lysosomes with Extracellular Vesicles and their Enhanced Brain Distribution in the Animal Model of Batten Disease.

Adv Healthc Mater 2019 Apr 18:e1801271. Epub 2019 Apr 18.

Center for Nanotechnology in Drug Delivery and Carolina Institute for Nanomedicine, University of North Carolina at Chapel Hill, Chapel Hill, NC, 27599, USA.

Extracellular vesicles (EVs) are promising natural nanocarriers for delivery of various types of therapeutics. Earlier engineered EV-based formulations for neurodegenerative diseases and cancer are reported. Herein, the use of macrophage-derived EVs for brain delivery of a soluble lysosomal enzyme tripeptidyl peptidase-1, TPP1, to treat a lysosomal storage disorder, Neuronal Ceroid Lipofuscinoses 2 (CLN2) or Batten disease, is investigated. Read More

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http://dx.doi.org/10.1002/adhm.201801271DOI Listing

Precise Surface Engineering of Cathode Materials for Improved Stability of Lithium-Ion Batteries.

Small 2019 Apr 17:e1901019. Epub 2019 Apr 17.

CAS Key Laboratory of Molecular Nanostructure and Nanotechnology, CAS Research/Education Center for Excellence in Molecular Sciences, Institute of Chemistry, Chinese Academy of Sciences (CAS), Beijing, 100190, P. R. China.

As lithium-ion batteries continue to climb to even higher energy density, they meanwhile cause serious concerns on their stability and reliability during operation. To make sure the electrode materials, particularly cathode materials, are stable upon extended cycles, surface modification becomes indispensable to minimize the undesirable side reaction at the electrolyte-cathode interface, which is known as a critical factor to jeopardizing the electrode performance. This Review is targeted at a precise surface control of cathode materials with focus on the synthetic strategies suitable for a maximized surface protection ensured by a uniform and conformal surface coating. Read More

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https://onlinelibrary.wiley.com/doi/abs/10.1002/smll.2019010
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http://dx.doi.org/10.1002/smll.201901019DOI Listing
April 2019
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Evidence of Spin Frustration in a Vanadium Diselenide Monolayer Magnet.

Adv Mater 2019 Apr 18:e1901185. Epub 2019 Apr 18.

Centre for Advanced 2D Materials (CA2DM) and Graphene Research Centre (GRC), National University of Singapore, 6 Science Drive 2, Singapore, 117546, Singapore.

Monolayer VSe , featuring both charge density wave and magnetism phenomena, represents a unique van der Waals magnet in the family of metallic 2D transition-metal dichalcogenides (2D-TMDs). Herein, by means of in situ microscopy and spectroscopic techniques, including scanning tunneling microscopy/spectroscopy, synchrotron X-ray and angle-resolved photoemission, and X-ray absorption, direct spectroscopic signatures are established, that identify the metallic 1T-phase and vanadium 3d electronic configuration in monolayer VSe grown on graphite by molecular-beam epitaxy. Element-specific X-ray magnetic circular dichroism, complemented with magnetic susceptibility measurements, further reveals monolayer VSe as a frustrated magnet, with its spins exhibiting subtle correlations, albeit in the absence of a long-range magnetic order down to 2 K and up to a 7 T magnetic field. Read More

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https://onlinelibrary.wiley.com/doi/abs/10.1002/adma.2019011
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http://dx.doi.org/10.1002/adma.201901185DOI Listing
April 2019
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17.493 Impact Factor

Potential of stem cell-derived exosomes to regenerate β islets through Pdx-1 dependent mechanism in a rat model of type 1 diabetes.

J Cell Physiol 2019 Apr 17. Epub 2019 Apr 17.

Faculty of Medicine, Mashhad University of Medical Sciences, Mashhad, Iran.

Type 1 diabetes, has been recognized as an autoimmune disease. Like other immunological conditions, regulation of immune response is a key strategy to control the autoimmunity in diabetic patients. Mesenchymal stem cells have been shown to have a distinct potential in modulating the immune reactions. Read More

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http://dx.doi.org/10.1002/jcp.28631DOI Listing

Report of the AAPS Guidance Forum on the FDA Draft Guidance for Industry: "Drug Products, Including Biological Products, that Contain Nanomaterials".

AAPS J 2019 Apr 17;21(4):56. Epub 2019 Apr 17.

VPS Consulting LLC, North Potomac, Maryland, USA.

To guide developers of innovative and generic drug products that contain nanomaterials, the U.S. Food and Drug Administration issued the draft guidance for industry titled: "Drug Products, Including Biological Products, that Contain Nanomaterials" in December 2017. Read More

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http://dx.doi.org/10.1208/s12248-019-0329-7DOI Listing

Electrocatalytic water oxidation over AlFeB.

Chem Sci 2019 Mar 23;10(9):2796-2804. Epub 2019 Jan 23.

Department of Chemistry and Biochemistry , Florida State University , 95 Chieftan Way , Tallahassee , FL 32306 , USA . Email:

We report excellent electrocatalytic performance by AlFeB in the oxygen-evolution reaction (OER). The inexpensive catalytic material, prepared simply by arc-melting followed by ball-milling, exhibits high stability and sustained catalytic performance under alkaline conditions. The overpotential value of 0. Read More

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http://xlink.rsc.org/?DOI=C8SC04106G
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http://dx.doi.org/10.1039/c8sc04106gDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6425857PMC
March 2019
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Ultraspecific live imaging of the dynamics of zebrafish neutrophil granules by a histopermeable fluorogenic benzochalcone probe.

Chem Sci 2019 Mar 14;10(12):3654-3670. Epub 2019 Feb 14.

MERIT , IRD , Université Paris 5 , Sorbonne Paris Cité , Paris , 75006 , France . Email:

Neutrophil granules (NGs) are key components of the innate immune response and mark the development of neutrophilic granulocytes in mammals. However, there has been no specific fluorescent vital stain up to now to monitor their dynamics within a whole live organism. We rationally designed a benzochalcone fluorescent probe () featuring high tissue permeability and optimal photophysics such as elevated quantum yield, pronounced solvatochromism and target-induced fluorogenesis. Read More

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http://xlink.rsc.org/?DOI=C8SC05593A
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http://dx.doi.org/10.1039/c8sc05593aDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6432617PMC
March 2019
2 Reads

Flux melting of metal-organic frameworks.

Chem Sci 2019 Mar 12;10(12):3592-3601. Epub 2019 Feb 12.

Department of Materials Science and Metallurgy , University of Cambridge , Charles Babbage Road , Cambridge , CB3 0FS , UK . Email:

Recent demonstrations of melting in the metal-organic framework (MOF) family have created interest in the interfacial domain between inorganic glasses and amorphous organic polymers. The chemical and physical behaviour of porous hybrid liquids and glasses is of particular interest, though opportunities are limited by the inaccessible melting temperatures of many MOFs. Here, we show that the processing technique of flux melting, 'borrowed' from the inorganic domain, may be applied in order to melt ZIF-8, a material which does not possess an accessible liquid state in the pure form. Read More

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http://xlink.rsc.org/?DOI=C8SC04044C
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http://dx.doi.org/10.1039/c8sc04044cDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6430010PMC
March 2019
2 Reads

Durable liquid-crystalline vitrimer actuators.

Chem Sci 2019 Mar 23;10(10):3025-3030. Epub 2019 Jan 23.

MOE Key Laboratory of Bioorganic Phosphorus Chemistry & Chemical Biology , Department of Chemistry , Tsinghua University , Beijing 100084 , China . Email:

Vitrimer-based liquid-crystalline elastomers (LCEs) exhibit great advantages over the traditional LCEs due to their inherent processability to realize monodomain alignment and construction of LCE actuators with complex 3D structures in a robust way. Though exciting progress has been made, how to achieve a proper balance between processability and actuation durability/stability remains a big challenge. Here, we report a strategy to mitigate the conflict between processability and actuation stability by reducing the catalyst content in an epoxy/acid LCE vitrimer system. Read More

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http://xlink.rsc.org/?DOI=C8SC05358H
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http://dx.doi.org/10.1039/c8sc05358hDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6427948PMC
March 2019
2 Reads

Proof-of-Concept Multistage Biomimetic Liposomal DNA Origami Nanosystem for the Remote Loading of Doxorubicin.

ACS Med Chem Lett 2019 Apr 31;10(4):517-521. Epub 2019 Jan 31.

Clinical and Experimental Pharmacology Unit, IRCCS CRO Aviano-National Cancer Institute, 33081 Aviano, Italy.

One of the most promising applications of DNA origami is its use as an excellent evolution of nanostructured intelligent systems for drug delivery, but short lifetime and immune-activation are still major challenges to overcome. On the contrary, stealth liposomes have long-circulation time and are well tolerated by the immune system. To overcome DNA origami limitations, we have designed and synthesized a compact short tube DNA origami (STDO) of approximately 30 nm in length and 10 nm in width. Read More

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http://dx.doi.org/10.1021/acsmedchemlett.8b00557DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6466551PMC

Dose- and duration-dependent cytotoxicity and genotoxicity in human hepato carcinoma cells due to CdTe QDs exposure.

Hum Exp Toxicol 2019 Apr 17:960327119843578. Epub 2019 Apr 17.

2 Department of Zoology, College of Science, King Saud University, Riyadh, Saudi Arabia.

Nanotechnology has achieved more commercial attention over recent years, and its application has increased concerns about its discharge in the environment. In this study, we have chosen human hepatic carcinoma (HuH-7) cells because liver tissue has played an important role in human metabolism. Therefore, the objective of this study was to determine DNA damaging and apoptotic potential of cadmium telluride quantum dots (CdTe QDs; average particle size (APS) 10 nm, 1-25 µg/ml) on HuH-7 cells and the basic molecular mechanism of its cellular toxicity. Read More

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http://dx.doi.org/10.1177/0960327119843578DOI Listing

Reply to "Comment on ' In Vivo Neuroimaging of Exosomes Using Gold Nanoparticles'".

ACS Nano 2018 Dec;12(12):11719-11720

Faculty of Engineering and the Institute of Nanotechnology & Advanced Materials Bar-Ilan University , Ramat Gan 5290002 , Israel.

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http://dx.doi.org/10.1021/acsnano.8b07946DOI Listing
December 2018