22,076 results match your criteria Nanomedicine: Nanotechnology Biology and Medicine [Journal]


Combinatory Cancer Therapeutics with Nanoceria-capped Mesoporous Silica Nanocarriers Through pH-triggered Drug Release and Redox Activity.

ACS Appl Mater Interfaces 2018 Dec 12. Epub 2018 Dec 12.

In the field of nanomedicine, drug-loaded nanocarriers that integrate nanotechnology and chemotherapeutics are widely used to achieve synergistic therapeutic effects. Here we prepared mesoporous silica nanoparticles capped with cerium oxide nanoparticles (COP@MSN) where a pH triggered-responsive mechanism was used to control drug release and intracellular drug delivery. We blocked the mesopores of the carboxyl functionalized MSN with aminated COP. Read More

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December 2018

Apically targeted oral micelles exhibit highly efficient intestinal uptake and oral absorption.

Int J Nanomedicine 2018 26;13:7997-8012. Epub 2018 Nov 26.

School of Chinese Materia Medica, Modern Research Center for Traditional Chinese Medicine, Beijing University of Chinese Medicine, Beijing, 100029, China,

Introduction: Polymeric micelles (PMs) hold promise for improving solubility and oral absorption of poorly soluble drugs. Unfortunately, the oral absorption of PMs is also limited by intestinal epithelium. To improve the oral delivery efficiency of micelles, transporter-mediated micelles could enhance the transport efficiency across the epithelial barrier, and they have attracted more attention. Read More

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November 2018

Sub-10 nm CuFeS cube for magnetic resonance imaging-guided photothermal therapy of cancer.

Int J Nanomedicine 2018 26;13:7987-7996. Epub 2018 Nov 26.

Department of Orthopedics, The First People's Hospital of Shangqiu, Shangqiu, Henan 476000, China.

Background: Facile synthesis and small size theranostic agents have shown great potential for cancer diagnosis and treatment.

Purpose: A ternary compound (CuFeS), Fe doped copper sulfide, with novel magnetic properties and strong near-infrared absorption was prepared for magnetic resonance imaging (MRI) imaging guided photothermal therapy of cancer.

Patients And Methods: Firstly, the capability of magnetic resonance imaging based on the novel magnetic properties and the photothermal performance due to the strong near-infrared absorption was investigated in vitro. Read More

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November 2018

Safe decontamination of cytostatics from the nitrogen mustards family. Part one: cyclophosphamide and ifosfamide.

Int J Nanomedicine 2018 26;13:7971-7985. Epub 2018 Nov 26.

Department of Oncology, 1st Faculty of Medicine, Charles University and General University Hospital in Prague, Prague, Czech Republic,

Introduction: Macrocrystalline oxides of alkaline earth metals (Mg and Ca) or light metals (Al and Ti) can respond to standard warfare agents such as sulfur mustard, soman, or agent VX. In this paper, we compared the decontamination ability of sodium hydroxide (NaOH) and sodium hypochlorite (NaClO) for nitrogen mustards (cyclophosphamide [CP] and ifosfamide [IFOS]) with a new procedure using a destructive sorbent based on nanocrystalline and nanodispersive titanium dioxide (TiO) as a new efficient and cheap material for complete decontamination of surfaces.

Methods: Titanium (IV) dioxide nanoparticles were prepared by the homogeneous hydrolysis of titanium(IV) oxysulfate (TiOSO) with urea. Read More

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November 2018

Novel application of trimethyl chitosan as an adjuvant in vaccine delivery.

Int J Nanomedicine 2018 23;13:7959-7970. Epub 2018 Nov 23.

Molecular Biology and Genetic Engineering Laboratory, School of Biotechnology, Jawaharlal Nehru University, New Delhi, India,

The application of natural carbohydrate polysaccharides for antigen delivery and its adjuvanation potential has garnered interest in the scientific community in the recent years. These biomaterials are considered favorable candidates for adjuvant development due to their desirable properties like enormous bioavailability, non-toxicity, biodegradability, stability, affordability, and immunostimulating ability. Chitosan is the one such extensively studied natural polymer which has been appreciated for its excellent applications in pharmaceuticals. Read More

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November 2018

Potential effects of different natural antioxidants on inflammatory damage and oxidative-mediated hepatotoxicity induced by gold nanoparticles.

Int J Nanomedicine 2018 23;13:7931-7938. Epub 2018 Nov 23.

Department of Physics and Astronomy, College of Science, King Saud University, Riyadh, Saudi Arabia,

Objective: The objective of this study was to verify and confirm the oxidative-mediated hepatotoxicity, inflammatory liver damage, and oxidative stress induced by intraperitoneal administration of gold nanoparticles (GNPs) in vivo; characterize the effect of different natural antioxidants on these hazardous changes; and finally choose the most powerful antioxidant among these different natural antioxidants.

Methods: Ten-nanometer GNPs were dissolved in aqueous solution of 0.01% concentration. Read More

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November 2018

Vascular targeted nanotherapeutic approach for obesity treatment.

Int J Nanomedicine 2018 23;13:7915-7929. Epub 2018 Nov 23.

Department of Science and Technology/Mintek Nanotechnology Innovation Centre, Biolabels Unit, Department of Biotechnology, University of the Western Cape, Bellville, South Africa,

Obesity is a global epidemic that poses a serious health concern due to it being a risk factor for life-threatening chronic diseases, such as type 2 diabetes, cancer, and cardiovascular diseases. Pharmacotherapy remains the mainstay for the management of obesity; however, its usefulness is limited due to poor drug efficacy, non-specificity and toxic side effects. Therefore, novel approaches that could provide insights into obesity and obesity-associated diseases as well as development of novel anti-obesity treatment modalities or improvement on the existing drugs are necessary. Read More

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November 2018

Macrophage uptake switches on OCT contrast of superparamagnetic nanoparticles for imaging of atherosclerotic plaques.

Int J Nanomedicine 2018 23;13:7905-7913. Epub 2018 Nov 23.

Department of Radiology, Charité-Universitätsmedizin Berlin, Germany,

Background: Optical coherence tomography (OCT) is an intravascular, high-resolution imaging technique that is used to characterize atherosclerotic plaques. However, the identification of macrophages as important markers of inflammation and plaque vulnerability remains difficult. Here, we investigate whether the uptake of very small iron oxide particles (VSOP) in macrophages, that cluster in phagolysosomes and allow high-quality magnetic resonance imaging (MRI) of atherosclerotic plaques, and uptake of ferumoxytol nanoparticles enhance detection of macrophages by OCT. Read More

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November 2018

Electrospun nanofiber blend with improved mechanical and biological performance.

Int J Nanomedicine 2018 22;13:7891-7903. Epub 2018 Nov 22.

Division of Engineering in Medicine, Department of Medicine, Brigham and Women's Hospital, Harvard Medical School, Cambridge, MA 02139, USA,

Background: Here, electrospun fibers based on a blend of polycaprolactone (PCL), poly(ethylene glycol) (PEG), and gelatin methacryloyl (GelMA) were developed. The careful choice of this polymer combination allowed for the preparation of a biomaterial that preserved the mechanical strength of PCL, while at the same time improving the hydrophilicity of the blended material and human osteoblast maturation.

Methods: The morphology, chemical structure, wettability, and mechanical properties before and after UV photocrosslinking were evaluated. Read More

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November 2018

Fabrication and evaluation of a γ-PGA-based self-assembly transferrin receptor-targeting anticancer drug carrier.

Int J Nanomedicine 2018 22;13:7873-7889. Epub 2018 Nov 22.

School of Life Sciences, East China Normal University, Shanghai 200241, China,

Background: cis-Dichlorodiamineplatinum (CDDP) was one of the most common used drugs in clinic for cancer treatment. However, CDDP caused a variety of side effects. The abundant carboxyl groups on the surface of poly glutamic acid (PGA) could be modified with various kinds of targeted ligands. Read More

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November 2018

Targeted delivery of reduced graphene oxide nanosheets using multifunctional ultrasound nanobubbles for visualization and enhanced photothermal therapy.

Int J Nanomedicine 2018 22;13:7859-7872. Epub 2018 Nov 22.

Department of Ultrasound, Harbin Medical University Cancer Hospital, Nangang District, Harbin 150080, China,

Ultrasound molecular imaging as a promising strategy, which involved the use of molecularly targeted contrast agents, combined the advantages of contrast-enhanced ultrasound with the photothermal effect of reduced graphene oxide (rGO).

Methods And Results: The heparin sulfate proteoglycan glypican-3 (GPC3) is a potential molecular target for hepatocellular carcinoma (HCC). In this study, we covalently linked biotinylated GPC3 antibody to PEGylated nano-rGO to obtain GPC3-modified rGO-PEG (rGO-GPC3), and then combined rGO-GPC3 with avidinylated nanobubbles (NBs) using biotin-avidin system to prepare NBs-GPC3-rGO with photothermal effect and dispersibility, solubility in physiological environment. Read More

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November 2018

Mechanism research on a bioactive resveratrol- PLA-gelatin porous nano-scaffold in promoting the repair of cartilage defect.

Int J Nanomedicine 2018 22;13:7845-7858. Epub 2018 Nov 22.

Department of Orthopedics and Trauma, Peking University People's Hospital, Beijing, China,

Background: Articular cartilage defects are difficult to treat, but drug-loaded tissue engineering scaffolds provide a possible treatment option for these types of injuries.

Purpose: In this study, we designed a bioactive resveratrol-PLA-gelatin porous nano-scaffold using electrospinning, freeze drying, and uniform dispersion techniques to repair articular cartilage defects, and then investigated the possible mechanism behind the successful repair.

Methods: We established an articular cartilage defect rat model with a 2 mm diameter wound in the middle of the knee joint femoral condyle non-weight-bearing area, with a depth reaching the full thickness of the subchondral bone. Read More

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November 2018

Dimethyl 2,2'-[2,2'-(ethane-1,1-diyl)bis(1-indole-3,2-diyl)]-diacetate: a small molecule capable of nano-scale assembly, inhibiting venous thrombosis and inducing no bleeding side effect.

Int J Nanomedicine 2018 22;13:7835-7844. Epub 2018 Nov 22.

Beijing Area Major Laboratory of Peptide and Small Molecular Drugs, School of Pharmaceutical Sciences, Capital Medical University, Beijing 100069, China,

Background: Due to the discovery that deep venous thrombosis (DVT) inhibitor is of chemotherapeutic importance, the nano-property of dimethyl 2,2'-[2,2'-(ethane-1,1-diyl) bis(1-indole-3,2-diyl)]-diacetate (DEBIC), a recently reported antitumor agent, is worthy of characterization.

Materials And Methods: One-pot reaction was used to prepare DEBIC. Electrospray Ionization (+/-)-Fourier Transform-Ion Cyclotron Resonance-Mass Spectrometer (ESI(+/-)-FT-ICR-MS), quadrupole Collision Induced Dissociation (qCID) and nuclear overhauser effect spectroscopy spectra were used to present the assembly of DEBIC. Read More

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November 2018

Co-exposure subacute toxicity of silica nanoparticles and lead acetate on cardiovascular system.

Int J Nanomedicine 2018 21;13:7819-7834. Epub 2018 Nov 21.

Department of Toxicology and Sanitary Chemistry, School of Public Health, Capital Medical University, Beijing 100069, PR China,

Background: The harmful effects following the release of nanomaterials into environment are of great concern today.

Purpose: In this study, subacute effect due to co-exposure to low-dose silica nanoparticles (SiNPs) and lead acetate (Pb) on cardiovascular system was detected in Sprague Dawley male rats.

Materials And Methods: Histopathological and ultrastructural changes of heart, aortic arch and abdominal aorta were detected. Read More

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November 2018

A Zr-labeled lipoplex nanosystem for image-guided gene delivery: design, evaluation of stability and in vivo behavior.

Int J Nanomedicine 2018 21;13:7801-7818. Epub 2018 Nov 21.

Drug Discovery and Development Research Group, College of Pharmacy and Nutrition, University of Saskatchewan, Saskatoon, SK S7N 5E5, Canada,

Background: With the advances in radiopharmaceutical research, the development of image-guided therapy has become a major interest. While the development of theranostic nanotherapeutics is frequently associated with cancer chemotherapy, phototherapy and radiotherapy, there is little information available on the in vivo monitoring of gene delivery systems and the application of image-guided approach in gene therapy. The goal of this work was to determine the in vivo behavior of DNA delivery nanosystems - based on cationic gemini surfactants - designed for image-guided gene therapy. Read More

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November 2018

Biogenic pentagonal silver nanoparticles for safer and more effective antibacterial therapeutics.

Int J Nanomedicine 2018 21;13:7789-7799. Epub 2018 Nov 21.

Nanomedicine & Nanobiotechnology Lab, Department of Biosciences, Integral University, Dasauli, Lucknow, India,

Background: Biological synthesis of nanomaterials possesses unprecedented potential in the production of nanomaterials due to their ability to produce nanomaterials with improved biocompatibility in addition to eco-friendly synthetic procedures.

Methods: This article reports the isolation of an air-borne fungus from the campus of Integral University, Lucknow, with an exceptional ability to withstand very high concentrations of silver salt. The fungus was found to produce pentagonal silver nanoparticles (AgPgNps) when silver ions were reduced from silver nitrate. Read More

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November 2018

Nitric oxide-releasing nanoparticles improve doxorubicin anticancer activity.

Int J Nanomedicine 2018 20;13:7771-7787. Epub 2018 Nov 20.

Department of Drug Science, University of Catania, Catania, Italy.

Purpose: Anticancer drug delivery systems are often limited by hurdles, such as off-target distribution, slow cellular internalization, limited lysosomal escape, and drug resistance. To overcome these limitations, we have developed a stable nitric oxide (NO)-releasing nanoparticle (polystyrene-maleic acid [SMA]--dodecane S-nitrosothiol [tDodSNO]) with the aim of enhancing the anticancer properties of doxorubicin (Dox) and a Dox-loaded nanoparticle (SMA-Dox) carrier.

Materials And Methods: Effects of SMA-tDodSNO and/or in combination with Dox or SMA-Dox on cell viability, apoptosis, mitochondrial membrane potential, lysosomal membrane permeability, tumor tissue, and tumor growth were studied using in vitro and in vivo model of triple-negative breast cancer (TNBC). Read More

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November 2018

Effects of quercetin and arginine on the nephrotoxicity and lipid peroxidation induced by gold nanoparticles in vivo.

Int J Nanomedicine 2018 21;13:7765-7770. Epub 2018 Nov 21.

Department of Physics and Astronomy, College of Science, King Saud University, Riyadh, Saudi Arabia,

Introduction: This study aimed to evaluate the nephrotoxicity caused by gold nanoparticles (GNPs) and investigate the potential roles of quercetin (Qur) and arginine (Arg) in mitigating the inflammatory kidney damage and dysfunction and inhibiting the toxicity induced by GNPs in rats.

Methods: Kidney function was assessed using various serum biomarkers, including blood urea nitrogen (BUN), uric acid (URIC), and creatinine (CR), while toxicity was evaluated by measuring the biomarkers glutathione (GSH) and malondialdehyde (MDA) in kidney tissues.

Results: Administration of GNPs to the rats severely affected the serum kidney biomarkers, as confirmed by the notable increases in BUN, URIC, and CR. Read More

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November 2018

Recent advances in ultrasound-based transdermal drug delivery.

Int J Nanomedicine 2018 20;13:7749-7763. Epub 2018 Nov 20.

School of Chemistry, Monash University, Clayton, VIC 3800, Australia,

The transdermal transport of pharmaceuticals possesses various advantageous properties over conventional drug administration techniques such as oral delivery and hypodermic injections. However, the stratum corneum persists as the main barrier, which impedes percutaneous transport. The ultrasound-based transdermal delivery of therapeutics is one of the techniques that are being investigated to overcome this obstacle. Read More

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November 2018

Exosome-mediated delivery of functionally active miRNA-142-3p inhibitor reduces tumorigenicity of breast cancer in vitro and in vivo.

Int J Nanomedicine 2018 20;13:7727-7747. Epub 2018 Nov 20.

Department of Medical Biotechnology, Faculty of Medical Sciences, Tarbiat Modares University, Tehran, Iran,

Background: Exosomes, widely recognized natural nanovesicles, represent one of the recently discovered modes of intercellular communication due to their ability to transmit crucial cellular information that can be engineered to have robust delivery and targeting capacity. MiR-142-3p, one of the upregulated microRNAs (miRNAs) in many types of breast cancer, activates the canonical Wnt signaling pathway and transactivates the miR-150 expression, and results in the hyperproliferation of cancer cells in vitro and mammary glands in vivo.

Materials And Methods: In this study, we exploited the exosomes isolated from bone marrow-derived mesenchymal stem cells (MSCs-Exo) to deliver LNA (locked nucleic acid)-modified anti-miR-142-3p oligonucleotides to suppress the expression level of miR-142-3p and miR-150 in 4T1 and TUBO breast cancer cell lines. Read More

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November 2018

Lipid surface modifications increase mesoporous silica nanoparticle labeling properties in mesenchymal stem cells.

Int J Nanomedicine 2018 20;13:7711-7725. Epub 2018 Nov 20.

Department of Instructive Biomaterials Engineering, MERLN Institute for Technology-Inspired Regenerative Medicine, Maastricht University, 6229 ER MD, Maastricht, the Netherlands,

Background: Nanoparticles have emerged as promising cell-labeling tools, as they can be precisely tailored in terms of chemical and physical properties. Mesoporous silica nanoparticles (MSNs), in particular, are easily tunable with regard to surface and core chemistry, and are able to confine dyes and drug molecules efficiently.

Purpose: The aim of this study was to investigate the effect of lipid and polyethylene glycol (PEG) surface modifications on MSN stem-cell-tracking abilities. Read More

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November 2018

Redox/pH dual-controlled release of chlorhexidine and silver ions from biodegradable mesoporous silica nanoparticles against oral biofilms.

Int J Nanomedicine 2018 19;13:7697-7709. Epub 2018 Nov 19.

Department of Oral Implantology, Affiliated Hospital of Stomatology, Nanjing Medical University, Nanjing, 210029, China,

Background: Oral plaque biofilms pose a threat to periodontal health and are challenging to eradicate. There is a growing belief that a combination of silver nanoparticles and chlorhexidine (CHX) is a promising strategy against oral biofilms.

Purpose: To overcome the side effects of this strategy and to exert maximum efficiency, we fabricated biodegradable disulfide-bridged mesoporous silica nanoparticles (MSNs) to co-deliver silver nanoparticles and CHX for biofilm inhibition. Read More

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November 2018

Novel pH-sensitive zinc phthalocyanine assembled with albumin for tumor targeting and treatment.

Int J Nanomedicine 2018 19;13:7681-7695. Epub 2018 Nov 19.

College of Chemistry, Fuzhou University, Fuzhou, Fujian, China.

Purpose: Zinc phthalocyanine (ZnPc) has been applied widely in photodynamic therapy (PDT) with high ROS-production capacity and intense absorption in the near-infrared region. However, weak tumor targeting and the aggregation tendency of ZnPc seriously affect the therapeutic effect of PDT. Therefore, overcoming the aggregation of ZnPc and enhancing its antitumor effect were the purpose of this study. Read More

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November 2018

Decapeptide functionalized targeted mesoporous silica nanoparticles with doxorubicin exhibit enhanced apoptotic effect in breast and prostate cancer cells.

Int J Nanomedicine 2018 19;13:7669-7680. Epub 2018 Nov 19.

Nanobioscience Group, Agharkar Research Institute, Pune, India,

Background: Considering the increase in cancer cases and number of deaths per year worldwide, development of potential therapeutics is imperative. Mesoporous silica nanoparticles (MSNPs) are among the potential nanocarriers having unique properties for drug delivery. Doxorubicin (DOX), being the most commonly used drug, can be efficiently delivered to gonadotropin-releasing hormone (GnRH)-overexpressing cancer cells using functionalized MSNPs. Read More

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November 2018

Initial osteoblast adhesion and subsequent differentiation on zirconia surfaces are regulated by integrins and heparin-sensitive molecule.

Int J Nanomedicine 2018 19;13:7657-7667. Epub 2018 Nov 19.

Division of Advanced Prosthetic Dentistry, Graduate School of Dentistry, Tohoku University, Sendai, Japan.

Purpose: It is well known that zirconia materials have good biocompatibility; however, little is known regarding the mechanism by which cells attach to these materials. The purpose of this study is to elucidate the mechanism of cell attachment.

Materials And Methods: In this study, we examined the surface characteristics of ceria-stabilized zirconia/alumina nanocomposite (NANOZR), yttria-stabilized zirconia (Y-TZP) and commercially pure titanium (CpTi), and we evaluated the initial response of osteoblast-like cells to them with different inhibitors. Read More

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November 2018

Folate receptor targeting of radiolabeled liposomes reduces intratumoral liposome accumulation in human KB carcinoma xenografts.

Int J Nanomedicine 2018 19;13:7647-7656. Epub 2018 Nov 19.

Department of Micro- and Nanotechnology, DTU Nanotech, Technical University of Denmark, DK-2800 Kongens Lyngby, Denmark,

Background: Active, ligand-mediated, targeting of functionalized liposomes to folate receptors (FRs) overexpressed on cancer cells could potentially improve drug delivery and specificity. Studies on folate-targeting liposomes (FTLs) have, however, yielded varying results and generally fail to display a clear benefit of FR targeting.

Method: Tumor accumulating potential of FTLs and NTLs were investigated in a FR overex-pressing xenograft model by positron emission tomography/computed tomography imaging. Read More

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November 2018

Tailor-made PL-UC-C3 nanoparticles for fluorescence/computed tomography imaging-guided cascade amplified photothermal therapy.

Int J Nanomedicine 2018 19;13:7633-7646. Epub 2018 Nov 19.

Department of Biomedical Engineering, College of Engineering and Applied Sciences, Nanjing University, Nanjing, Jiangsu 210093, China,

Background: Development of the burgeoning number of photothermal therapy (PTT) agents has drawn a huge amount of interest, since PTT treatment is a powerful and effective alternative to traditional treatments. Optimal PTT agents should integrate some essential preconditions including negligible systemic toxicity, deep penetration into tumor tissues, and maximum laser energy absorbance. Unfortunately, only few of the PTT agents reported could meet all of the above mentioned conditions. Read More

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November 2018

Enhanced photo/chemo combination efficiency against bladder tumor by encapsulation of DOX and ZnPC into in situ-formed thermosensitive polymer hydrogel.

Int J Nanomedicine 2018 19;13:7623-7631. Epub 2018 Nov 19.

Department of Urology, Peking Union Medical College Hospital, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing 100730, China,

Background: Chemotherapy after transurethral resection is commonly recommended for bladder cancer. However, studies have shown that chemotherapy solely can hardly decrease progression rates of bladder cancer. The combination of chemotherapeutic agents with photo-dynamic therapy (PDT), a new promising localized therapy, may become a workable strategy for combating bladder cancer. Read More

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November 2018

Biomimetic intrafibrillar mineralized collagen promotes bone regeneration via activation of the Wnt signaling pathway.

Int J Nanomedicine 2018 21;13:7503-7516. Epub 2018 Nov 21.

Department of Oral & Maxillofacial-Head & Neck Oncology, Shanghai Ninth People's Hospital, Shanghai Jiaotong University School of Medicine, Shanghai Key Laboratory of Stomatology & Shanghai Research, Institute of Stomatology and National Clinical Research Center of Stomatology, Shanghai, China,

Purpose: The purpose of this study was to assess the effects of biomimetic intrafibrillar mineralized collagen (IMC) bone scaffold materials on bone regeneration and the underlying biological mechanisms.

Materials And Methods: A critical-sized bone defect in the rat femur was created; then IMC, extrafibrillar mineralized collagen, and nano-hydroxyapatite bone scaffold materials were grafted into the defect. Ten weeks after implantation, micro-computed tomography and histology were applied to evaluate the bone regeneration. Read More

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November 2018

Pep-1&Borneol-bifunctionalized carmustin-loaded micelles enhance anti-glioma efficacy through tumor targeting and BBB penetratings.

J Pharm Sci 2018 Dec 8. Epub 2018 Dec 8.

Department of Neurosurgery, School of Medicine, Zhongda Hospital, Southeast University, Nanjing 210009, China. Electronic address:

Tumor-targeting and blood-brain barrier (BBB)-penetrating are highly desirable for the treatment of glioma. In this study, we developed Pep-1&borneol-bifunctionalized carmustin-loaded micelles (Pep-1/Bor/CMS-M) capable of targeting to IL-13 receptor-overexpressed glioma and penetrating the brain microvascular endothelial cells-associated physiologic barriers. Pep-1/Bor/CMS-M were nearly spherical particles with a diameter of 32. Read More

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December 2018
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Molecular scaffolds as double targeting agents for the diagnosis and treatment of Neuroblastoma.

Angew Chem Int Ed Engl 2018 Dec 10. Epub 2018 Dec 10.

Universidad Complutense de Madrid, Facultad de Farmacia, Ciudad Universitaria, 28040, Madrid, SPAIN.

The selective delivery of therapeutic and imaging agents to tumoral cells has been postulated as some of the most important challenges in nanomedicine field. The cellular selectivity of nanocarriers is usually achieved by their surface decoration with targeting moieties able to recognize these cells in a specific manner. Neuroblastoma (NB) is the most frequent extra-cranial pedriatic tumor, almost incurable at advanced stages. Read More

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December 2018

Critical Considerations on the Clinical Translation of Upconversion Nanoparticles (UCNPs): Recommendations from the European Upconversion Network (COST Action CM1403).

Adv Healthc Mater 2018 Dec 10:e1801233. Epub 2018 Dec 10.

Institute of Analytical Chemistry, Chemo- and Biosensors, University of Regensburg, 93040, Regensburg, Germany.

The unique photoluminescent properties of upconversion nanoparticles (UCNPs) have attracted worldwide research interest and inspired many bioanalytical applications. The anti-Stokes emission with long luminescence lifetimes, narrow and multiple absorption and emission bands, and excellent photostability enable background-free and multiplexed detection in deep tissues. So far, however, in vitro and in vivo applications of UCNPs are restricted to the laboratory use due to safety concerns. Read More

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December 2018
4.880 Impact Factor

Multimodal imaging of the tumor microenvironment and biological responses to immune therapy.

Biomed Microdevices 2018 Dec 3;20(4). Epub 2018 Dec 3.

Michael E. DeBakey Department of Surgery, Baylor College of Medicine, Houston, TX, 77030, USA.

Beyond heterogeneous cancer cells, the tumor microenvironment includes stromal and immune cells, blood vessels, extracellular matrix and biologically active molecules. Abnormal signaling, uncontrolled proliferation and high interstitial pressure all contribute to a chaotic, non-hierarchical vascular organization. Using an immune competent 4T1 breast adenocarcinoma murine model, this study fully characterizes the architecture and immunocyte milieu of the tumor microenvironment. Read More

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December 2018
3 Reads
2.877 Impact Factor

Granulocyte-macrophage colony-stimulating factor receptor expression in clinical pain disorder tissues and role in neuronal sensitization.

Pain Rep 2018 Sep-Oct;3(5):e676. Epub 2018 Sep 17.

Peripheral Neuropathy Unit, Centre for Clinical Translation, Department of Medicine, Hammersmith Hospital, Imperial College London, London, United Kingdom.

Introduction: Granulocyte-macrophage colony-stimulating factor receptor (GM-CSFR) is highly expressed in peripheral macrophages and microglia, and is involved in arthritis and cancer pain in animal models. However, there is limited information on GM-CSFR expression in human central nervous system (CNS), peripheral nerves, or dorsal root ganglia (DRG), particularly in chronic pain conditions.

Objectives: Immunohistochemistry was used to quantify GM-CSFR expression levels in human tissues, and functional sensory effects of GM-CSF were studied in cultured DRG neurons. Read More

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September 2018

Challenges and Opportunities of Nanotechnology as Delivery Platform for Tocotrienols in Cancer Therapy.

Front Pharmacol 2018 26;9:1358. Epub 2018 Nov 26.

Product Development and Advisory Services Division, Malaysian Palm Oil Board, Bandar Baru Bangi, Malaysia.

Plant-derived phytonutrients have emerged as health enhancers. Tocotrienols from the vitamin E family gained high attention in recent years due to their multi-targeted biological properties, including lipid-lowering, neuroprotection, anti-inflammatory, antioxidant, and anticancer effects. Despite well-defined mechanism of action as an anti-cancer agent, their clinical use is hampered by poor pharmacokinetic profile and low oral bioavailability. Read More

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November 2018

STAT3-siRNA induced B16.F10 melanoma cell death: more association with VEGF downregulation than p-STAT3 knockdown.

Authors:
Aws Alshamsan

Saudi Pharm J 2018 Dec 30;26(8):1083-1088. Epub 2018 May 30.

Nanomedicine Research Unit, Department of Pharmaceutics, College of Pharmacy, King Saud University, Saudi Arabia.

STAT3 knockdown by small interfering RNA (siRNA) has been described to inhibit carcinogenic growth in various types of tumors. Earlier we have reported delivery of siRNA by oleic acid- and stearic acid-modified-polyethylenimine and enhancement of silencing of STAT3 by small interfering RNA (siRNA) in B16.F10 melanoma cell lines and consequent tumor suppression. Read More

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December 2018

Reverse micelle-lipid nanocapsules: a novel strategy for drug delivery of the plectasin derivate AP138 antimicrobial peptide.

Int J Nanomedicine 2018 15;13:7565-7574. Epub 2018 Nov 15.

Micro & Nanomédecines Translationelles-MINT, UNIV Angers, INSERM U1066, CNRS UMR 6021, UBL Universite Bretagne Loire, Angers, France.

Introduction: Resistance to traditional antibiotics is an increasingly serious problem. Antimicrobial peptides (AMPs) have emerged as a new therapeutic class with great potential against infectious diseases, as they are less prone to induce resistance. Nanotechnology-based delivery strategies can improve the efficiency and stability of AMPs, particularly against proteolytic degradation. Read More

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November 2018

Enhanced anticancer activity and intracellular uptake of paclitaxel-containing solid lipid nanoparticles in multidrug-resistant breast cancer cells.

Int J Nanomedicine 2018 15;13:7549-7563. Epub 2018 Nov 15.

Department of Pharmaceutical Sciences, Woosuk University, Jeonbuk, South Korea,

Purpose: The aim of this study was to show enhanced anticancer activity of paclitaxel (Ptx) incorporated into solid lipid nanoparticles (SLNs) and reveal reversal of multidrug resistance (MDR) by SLNs mediated by increased uptake through different entry mechanisms from that in drug-sensitive cells.

Methods: Anticancer activity of Ptx incorporated in SLNs (Ptx-SLNs) was measured in the drug-sensitive human breast cancer cell line MCF7 and its MDR variant MCF7/ADR. Cellular uptake of cargo molecules in SLNs was compared using Ptx-SLNs and rhodamine 123-loaded SLNs (Rho-SLNs) in both cell lines. Read More

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November 2018

Bufalin-loaded vitamin E succinate-grafted-chitosan oligosaccharide/RGD conjugated TPGS mixed micelles demonstrated improved antitumor activity against drug-resistant colon cancer.

Int J Nanomedicine 2018 15;13:7533-7548. Epub 2018 Nov 15.

Interventional Cancer Institute of Chinese Integrative Medicine, Putuo Hospital, Shanghai University of Traditional Chinese Medicine, Shanghai 200062, People's Republic of China,

Background: Multidrug resistance (MDR) is the major reason for the failure of chemotherapy in colon cancer. Bufalin (BU) is one of the most effective antitumor active constituents in Chansu. Our previous study found that BU can effectively reverse P-glycoprotein (P-gp)-mediated MDR in colon cancer. Read More

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November 2018
1 Read

A666-conjugated nanoparticles target prestin of outer hair cells preventing cisplatin-induced hearing loss.

Int J Nanomedicine 2018 14;13:7517-7531. Epub 2018 Nov 14.

Department of Otolaryngology-Head and Neck Surgery, Shanghai Ninth People's Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai, People's Republic of China,

Background: The delivery of treatment agents to inner ear with drug delivery system (DDS) has been under investigation to overcome the limitations of the conventional therapeutic agents in curing or alleviating the cisplatin ototoxicity.

Methods: In the present study, a novel targeted dexamethasone (DEX)-loaded DDS, A666-DEX-NP, was constructed for prevention from cisplatin-induced hearing loss. A666-(CLEPRWGFGWWLH) peptides specifically bind to prestin, which is limited to the outer hair cells (OHCs). Read More

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November 2018

Controlled and sustained drug release performance of calcium sulfate cement porous TiO microsphere composites.

Int J Nanomedicine 2018 14;13:7491-7501. Epub 2018 Nov 14.

Tianjin Key Laboratory of Composite and Functional Materials, School of Materials Science and Engineering, Tianjin University, Tianjin, China,

Background: Calcium sulphate cement (CSC) is widely used as an osteoconductive biomaterial in bone repair and regeneration.

Purpose: In this study, porous TiO microspheres were added to CSC to achieve a controlled and sustained drug (gentamicin) release.

Methods: Scanning electron microscopy (SEM), transmission electron microscopy (TEM), X-ray powder diffraction (XRD), and Brunauer-Emmett-Teller (BET) surface area analysis were conducted to analyse the morphology, phase composition, and surface area of the TiO micro-spheres and composite cements. Read More

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November 2018

Selenium as a pleiotropic agent for medical discovery and drug delivery.

Int J Nanomedicine 2018 14;13:7473-7490. Epub 2018 Nov 14.

Department of Pharmaceutics, College of Pharmacy, Jinan University, Guangzhou, China,

Selenium as a biologically active element lends much support to health maintenance and disease prevention. It is now presenting pleiotropic effects on therapy and drug delivery. In this study, a profiling on the physiological functions, therapeutic significances, clinical/preclinical performances, and biomedical and drug delivery applications of selenium in different modalities was carried out. Read More

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November 2018
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Redox-responsive hyaluronic acid-functionalized graphene oxide nanosheets for targeted delivery of water-insoluble cancer drugs.

Int J Nanomedicine 2018 14;13:7457-7472. Epub 2018 Nov 14.

Cancer Metastasis Alert and Prevention Center, and Biopharmaceutical Photocatalysis, State Key Laboratory of Photocatalysis on Energy and Environment, Fuzhou University, Fuzhou 350002, China,

Background: Gefitinib (Gef), an important epidermal growth factor receptor (EGFR), is used to treat lung cancer, but low water solubility and poor bioavailability severely limit its application in cancer therapy.

Methods: In this study, nanographene oxide (NGO) was decorated with hyaluronic acid (HA) by a linker cystamine dihydrochloride containing disulfide bonds (-SS-), followed by the incorporation of gefitinib, thus, constructing a HA-functionalized GO-based gefitinib delivery system (NGO-SS-HA-Gef). Subsequently, studies of biological experiments in vitro and in vivo were performed to investigate the therapeutic effect of the system in lung cancer. Read More

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November 2018

Regulation of in vivo behavior of TAT-modified liposome by associated protein corona and avidity to tumor cells.

Int J Nanomedicine 2018 15;13:7441-7455. Epub 2018 Nov 15.

Laboratory of Experimental Surgical Oncology, Section of Surgical Oncology, Department of Surgery, Erasmus Medical Center, Rotterdam, the Netherlands,

Introduction: PEGylated liposomes are widely used and studied as carriers for chemotherapeutics. While pharmacokinetics of the encapsulated drug is drastically altered resulting in favorable circulation time, improved tumor accumulation, and better manageable or reduced side effects, therapeutic efficacy has been disappointing. Major drawbacks are a failure to reach the tumor cell, limited penetration depth, and impaired uptake by tumor cells. Read More

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November 2018

A niosome formulation modulates the Th1/Th2 bias immune response in mice and also provides protection against anthrax spore challenge.

Int J Nanomedicine 2018 14;13:7427-7440. Epub 2018 Nov 14.

Laboratory of Molecular Biology and Genetic Engineering, School of Biotechnology, Jawaharlal Nehru University, New Delhi, India,

Introduction: In this study, we have investigated the immunogenicity and protective efficacy of a niosomal formulation encapsulating protective antigen (PA) and PA domain 4 (D4) of .

Methods: Nonionic surfactant-based vesicles (NISV) + PA and NISV + D4 were prepared from span-60 and cholesterol by reverse-phase evaporation method and were evaluated for in vitro characteristics and immunological studies.

Results: Particle characterization using transmission electron microscopy and atomic force microscopy analysis showed that the niosomal formulation was spherical in shape. Read More

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November 2018

Safety and efficacy of the rSh28GST urinary schistosomiasis vaccine: a phase 3 randomized, controlled trial in Senegalese children.

PLoS Negl Trop Dis 2018 Dec 7;12(12):e0006968. Epub 2018 Dec 7.

Académie des Sciences, 23 Quai de Conti, Paris, France.

Background: Urinary schistosomiasis, the result of infection by Schistosoma haematobium (Sh), remains a major global health concern. A schistosome vaccine could represent a breakthrough in schistosomiasis control strategies, which are presently based on treatment with praziquantel (PZQ). We report the safety and efficacy of the vaccine candidate recombinant 28-kDa glutathione S-transferase of Sh (rSh28GST) designated as Bilhvax, in a phase 3 trial conducted in Senegal. Read More

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December 2018

Poincaré plot analysis of cerebral blood flow signals: Feature extraction and classification methods for apnea detection.

PLoS One 2018 7;13(12):e0208642. Epub 2018 Dec 7.

Biomedical Engineering Research Centre, Universitat Politècnica de Catalunya, CIBER of Bioengineering, Biomaterials and Nanomedicine (CIBER-BBN), Barcelona, Spain.

Objective: Rheoencephalography is a simple and inexpensive technique for cerebral blood flow assessment, however, it is not used in clinical practice since its correlation to clinical conditions has not yet been extensively proved. The present study investigates the ability of Poincaré Plot descriptors from rheoencephalography signals to detect apneas in volunteers.

Methods: A group of 16 subjects participated in the study. Read More

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December 2018

Nanotechnology-mediated crossing of two impermeable membranes to modulate the stars of the neurovascular unit for neuroprotection.

Proc Natl Acad Sci U S A 2018 Dec 10. Epub 2018 Dec 10.

Department of Biochemistry and Molecular Biology, Miller School of Medicine, University of Miami, Miami, FL 33136;

The success of nanoparticle-mediated delivery of antioxidant and antiinflammatory-based neuroprotectants to the brain to improve neuronal functions in neurodegenerative diseases has demonstrated lesser impact instead of achieving its full potential. We hypothesized that these failures were due to a combination of parameters, such as: () unavailability of a delivery vehicle, which can reproducibly and efficiently transport through the brain capillary endothelium; () inefficient uptake of therapeutic nanoparticles in the neuronal cell population; and () limited ability of a single nanoparticle to cross the two most-impermeable biological barriers, the blood-brain barrier and mitochondrial double membrane, so that a nanoparticle can travel through the brain endothelial barrier to the mitochondria of target cells where oxidative damage is localized. Herein, we demonstrate optimization of a biodegradable nanoparticle for efficient brain accumulation and protection of astrocytes from oxidative damage and mitochondrial dysfunctions to enhance the neuroprotection ability of astrocytes toward neurons using neurodegeneration characteristics in SOD1 rats. Read More

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December 2018

Strategies for Coexistence in Molecular Communication.

IEEE Trans Nanobioscience 2018 Dec 4. Epub 2018 Dec 4.

Some of the most ambitious applications of molecular communications are expected to lie in nanomedicine and advanced manufacturing. In these domains, the molecular communication system is surrounded by a range of biochemical processes, some of which may be sensitive to chemical species used for communication. Under these conditions, the biological system and the molecular communication system impact each other. Read More

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December 2018

Biomolecule-corona formation confers resistance of bacteria to nanoparticle-induced killing: Implications for the design of improved nanoantibiotics.

Biomaterials 2018 Nov 21;192:551-559. Epub 2018 Nov 21.

Department of Nanobiomedicine/ENT, University Medical Center of Mainz, Langenbeckstrasse 1, 55101, Mainz, Germany. Electronic address:

Multidrug-resistant bacterial infections are a global health threat. Nanoparticles are thus investigated as novel antibacterial agents for clinical practice, including wound dressings and implants. We report that nanoparticles' bactericidal activity strongly depends on their physical binding to pathogens, including multidrug-resistant primary clinical isolates, such as Staphylococcus aureus, Klebsiella pneumoniae or Enterococcus faecalis. Read More

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November 2018