23,057 results match your criteria Nanomedicine: Nanotechnology Biology and Medicine [Journal]


Electrospun essential oil-polycaprolactone nanofibers as antibiofilm surfaces against clinical Candida tropicalis isolates.

Biotechnol Lett 2019 Mar 16. Epub 2019 Mar 16.

Biotechnology Division, Biology Department, Faculty of Sciences, Hacettepe University, 06800, Beytepe, Ankara, Turkey.

Objective: As an approach to prevent biofilm infections caused by Candida tropicalis on various surfaces, determination of effect of biodegradable polycaprolactone nanofibers (PCLNFs) with different concentrations of two different essential oils were tested in this study.

Results: Both of the tested essential oils exhibited antifungal effect (minimal inhibitory concentration; 0.25-0. Read More

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http://dx.doi.org/10.1007/s10529-019-02660-yDOI Listing

Impact of superparamagnetic iron oxide nanoparticles (SPIONs) and ionic iron on physiology of summer squash (Cucurbita pepo): A comparative study.

Plant Physiol Biochem 2019 Mar 11;139:56-65. Epub 2019 Mar 11.

Department of Biophysics, Institute for Research and Medical Consultations (IRMC), Imam Abdulrahman Bin Faisal University, P.O. Box 34221, Dammam, Saudi Arabia.

This study investigates the effect of SPIONs (superparamagnetic iron oxide nanoparticles, ∼12.5 nm in size) on summer squash plant (Cucurbita pepo) in the presence and absence of supplementary iron (Fe(II)-EDTA). The plants were grown in nutrient solution with different iron sources: (i) Fe(II)-EDTA, (ii) without Fe(II)-EDTA (iii) SPIONs only, and (iv) Fe(II)-EDTA with SPIONs. Read More

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http://dx.doi.org/10.1016/j.plaphy.2019.03.011DOI Listing

Supramolecular nanoassembly of lysozyme and α-lactalbumin (apo α-LA) exhibits selective cytotoxicity and enhanced bioavailability of curcumin to cancer cells.

Colloids Surf B Biointerfaces 2019 Mar 8;178:297-306. Epub 2019 Mar 8.

Structural Biology and Nanomedicine Laboratory, Department of Biotechnology and Medical Engineering, National Institute of Technology Rourkela, Rourkela, 769008, Odisha, India. Electronic address:

Hybrid supramolecular spherical nanoassembly of hen egg white lysozyme and bovine apo α lactalbumin (SN) was prepared with a mean size of ˜55.2 nm using an optimized desolvation method via chemical crosslinking. The nanoassembly, SN demonstrated dose-dependent reactive oxygen species (ROS) mediated cytotoxicity in multiple cancer cells such as MCF-7, MDA-MB231, HeLa and MG 63. Read More

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http://dx.doi.org/10.1016/j.colsurfb.2019.03.016DOI Listing

NanoBioAnalytical characterization of extracellular vesicles in 75-nm nanofiltered human plasma for transfusion: A tool to improve transfusion safety.

Nanomedicine 2019 Mar 13. Epub 2019 Mar 13.

FEMTO-ST Institute, UBFC, CNRS, ENSMM, UTBM, 15B Avenue des Montboucons, 25030, Besançon, France. Electronic address:

Plasma transfusion induces some transfusion related acute lung injury (TRALI) mediated through neutrophil extracellular traps (NETs). We investigated whether extracellular vesicles (EVs) present in plasma or obtained from resting (N-PEVs) or thrombin activated platelets (T-PEVs) can trigger NETs, and whether 75nm-nanofiltration, to partially remove EVs, prohibits NETs formation. EVs size and concentration were determined by conventional biophysical approaches and by an original NanoBioAnalytical (NBA) platform based on EV immunocapture biochip, combining Surface Plasmon Resonance Imaging (SPRi) and Atomic Force Microscopy (AFM) exploration. Read More

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http://dx.doi.org/10.1016/j.nano.2019.02.026DOI Listing

Exploration of TiO nanoparticle mediated microdynamic therapy on Cancer treatment.

Nanomedicine 2019 Mar 13. Epub 2019 Mar 13.

Department of Orthopedics, Guangdong General Hospital, Guangdong, Academy of Medical Sciences, Guangzhou, China. Electronic address:

Radical therapy takes advantage of the reactive oxygen species produced in greater quantities within tumor cells than in normal cells. Here, for the first time, we explore a TiO nanoparticle mediated microwave induced radical therapy (termed as Microdynamic Therapy) as a new cancer treatment method. The experiments in vitro and in vivo demonstrate that colloidal TiO nanoparticles could significantly suppress the growth of osteosarcomas, even under low power (5W) microwave (MW) irradiation for 5min. Read More

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http://dx.doi.org/10.1016/j.nano.2019.02.016DOI Listing

Active viscosupplements for osteoarthritis treatment.

Semin Arthritis Rheum 2019 Feb 19. Epub 2019 Feb 19.

Group of Biomaterials, Department of Polymeric Nanomaterials and Biomaterials, Institute of Polymer Science and Technology (ICTP-CSIC), Madrid, Spain; Networking Biomedical Research Centre in Bioengineering, Biomaterials and Nanomedicine (CIBER-BBN), Madrid, Spain.

Objective: Osteoarthritis is a chronic, painful and disabling disease which prevalence is increasing in developing countries. Patients with osteoarthritis present a reduced synovial fluid viscoelasticity due to a reduction in concentration and molecular weight of hyaluronic acid. Currently, the main treatment used to restore the compromised rheological properties of synovial fluid is the viscosupplementation by hyaluronic acid injections that can be combined with oral anti-inflammatory drugs for pain relief. Read More

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http://dx.doi.org/10.1016/j.semarthrit.2019.02.008DOI Listing
February 2019

A UHPLC-MS/MS method coupled with simple and efficient alkaline hydrolysis for free and total determination of conjugate nanomedicine: Pharmacokinetic and biodistribution study of poly (l-glutamic acid)-graft-methoxy poly (ethylene glycol)/combretastatin A4.

J Pharm Biomed Anal 2019 Mar 5;169:215-224. Epub 2019 Mar 5.

College of Pharmacy, Laboratory Animal Science and Technology Center, Jiangxi University of Traditional Chinese Medicine, 1688 Meiling Road, Nanchang, 330004, PR China. Electronic address:

Poly (l-glutamic acid)-Combretastatin A4 conjugate (PLG-CA4) is a novel nano-anticancer drug. For macromolecule conjugate nanomedicine, its pharmacology mechanism is closely related to the pharmacokinetic profiles in vivo. It is a great significance that evaluates this polymer drug combined by covalently bound via studying the pharmacokinetics and distribution characteristics. Read More

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http://dx.doi.org/10.1016/j.jpba.2019.03.001DOI Listing

Highly electrocatalytic biosensor based on Hemin@AuNPs/reduced graphene oxide/chitosan nanohybrids for non-enzymatic ultrasensitive detection of hydrogen peroxide in living cells.

Biosens Bioelectron 2019 Feb 21;132:217-223. Epub 2019 Feb 21.

College of Chemistry and Molecular Engineering, Zhengzhou University, Zhengzhou 450001, China. Electronic address:

A non-enzymatic and highly electrocatalytic HO biosensor was proposed by using a novel electrode composed of hemin-capped biomineralized gold nanoparticles (Hem@AuNPs), reduced graphene oxide (rGO) and chitosan (CS). Owing to the excellent electrocatalytic activity of Hem@AuNPs and great conductivity of rGO, this developed biosensor is capable of ultrasensitive measuring HO in real-time. In addition, the introduction of CS resulted in a film on the electrode, which can enhance the stability by protecting the biosensor from external disturbances. Read More

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http://dx.doi.org/10.1016/j.bios.2019.02.039DOI Listing
February 2019

Liposomes produced by microfluidics and extrusion- a comparison for scale-up purposes.

Nanomedicine 2019 Mar 12. Epub 2019 Mar 12.

Department of Pharmaceutical Sciences, College of Pharmacy, Oregon State University/OHSU, Portland, Oregon, USA. Electronic address:

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http://dx.doi.org/10.1016/j.nano.2019.02.019DOI Listing

An ultrasensitive electrochemical aptasensor for early diagnosis of Alzheimer's disease, using a fern leaves-like gold nanostructure.

Authors:
M Negahdary H Heli

Talanta 2019 Jun 31;198:510-517. Epub 2019 Jan 31.

Nanomedicine and Nanobiology Research Center, Shiraz University of Medical Sciences, Shiraz, Iran. Electronic address:

An extremely sensitive and highly simple aptasensor was fabricated for quantitation of amyloid beta (Aβ) by electrochemical transduction of a fern leaves-like gold nanostructure. The gold nanostructure was synthesized by electrodeposition using polyethylene glycol 6000 as a shape-directing agent, and characterized electrochemically and by field emission scanning electron microscopy. A specific RNA aptamer was immobilized on the fern leaves-like gold nanostructure, and binding with Aβ was detected by the ferro/ferricyanide redox marker. Read More

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http://dx.doi.org/10.1016/j.talanta.2019.01.109DOI Listing

Consumer electronics devices for DNA genotyping based on loop-mediated isothermal amplification and array hybridisation.

Talanta 2019 Jun 10;198:424-431. Epub 2019 Feb 10.

Departamento de Química, Universitat Politècnica de València, Camino de Vera s/n, E46022 Valencia, Spain; Instituto Interuniversitario de Investigación de Reconocimiento Molecular y Desarrollo Tecnológico (IDM), Universitat Politècnica de València-Universitat de València, Valencia, Spain; Unidad Mixta UPV-La Fe, Nanomedicine and Sensors, IIS La Fe, Valencia, Spain.

Consumer electronic technologies offer practical performances to develop compact biosensing systems intended for the point-of-care testing of DNA biomarkers. Herein a discrimination method for detecting single nucleotide polymorphisms, based on isothermal amplification and on-chip hybridisation, was developed and integrated into user-friendly optical devices: e.g. Read More

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http://dx.doi.org/10.1016/j.talanta.2019.01.124DOI Listing

Polymeric Co-Delivery Systems in Cancer Treatment: An Overview on Component Drugs' Dosage Ratio Effect.

Molecules 2019 Mar 15;24(6). Epub 2019 Mar 15.

Center for Pharmaceutical Biotechnology and Nanomedicine, Northeastern University, Boston, MA 02115, USA.

Multiple factors are involved in the development of cancers and their effects on survival rate. Many are related to chemo-resistance of tumor cells. Thus, treatment with a single therapeutic agent is often inadequate for successful cancer therapy. Read More

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http://dx.doi.org/10.3390/molecules24061035DOI Listing
March 2019
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Innovative Therapeutic Strategies for Effective Treatment of Brain Metastases.

Int J Mol Sci 2019 Mar 14;20(6). Epub 2019 Mar 14.

Faculty of Medicine, the University of Queensland, Centre for Clinical Research, Herston, Queensland 4029, Australia.

Brain metastases are the most prevalent of intracranial malignancies. They are associated with a very poor prognosis and near 100% mortality. This has been the case for decades, largely because we lack effective therapeutics to augment surgery and radiotherapy. Read More

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http://dx.doi.org/10.3390/ijms20061280DOI Listing

Copper complex nanoformulations featuring highly promising therapeutic potential in murine melanoma models.

Nanomedicine (Lond) 2019 Mar 15. Epub 2019 Mar 15.

Research Institute for Medicines (iMed.ULisboa), Faculty of Pharmacy, Universidade de Lisboa, Av. Prof. Gama Pinto, 1649-003 Lisboa, Portugal.

Aim: Preclinical evaluation of a cytotoxic copper(II) complex formulated in long circulating nanoliposomes for melanoma treatment.

Materials & Methods: Liposomal nanoformulations of the copper complex were characterized in terms of thermodynamic behavior (differential scanning calorimeter), pH-sensitivity (spectrophotometry) and antiproliferative effects against murine melanoma B16F10 cells in vitro. Preclinical studies were performed in a C57BL/6 syngeneic melanoma model. Read More

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http://dx.doi.org/10.2217/nnm-2018-0388DOI Listing

Optical Nano-Printing of Colloidal Particles and Functional Structures.

ACS Nano 2019 Mar 15. Epub 2019 Mar 15.

Recent advances in chemical sciences have enabled the tailorable synthesis of colloidal particles with variable composition, size, shape and properties. Building superstructures with colloidal particles as building blocks is appealing for the fabrication of functional metamaterials and nanodevices. Optical nano-printing provides a versatile platform to print various particles into arbitrary configurations with nanometric precision. Read More

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http://dx.doi.org/10.1021/acsnano.9b01034DOI Listing

Transformable nanotherapeutics enabled by ICG: towards enhanced tumor penetration under NIR light irradiation.

Nanoscale 2019 Mar 15. Epub 2019 Mar 15.

Department of Nanomedicine and Biopharmaceuticals, College of Life Science and Technology, Huazhong University of Science and Technology, Wuhan, 430074, China. and National Engineering Research Center for Nanomedicine, College of Life Science and Technology, Huazhong University of Science and Technology, Wuhan, 430074, China and Hubei Key Laboratory of Bioinorganic Chemistry and Materia Medica, Huazhong University of Science and Technology, Wuhan, 430074, China.

Tumor penetration is the bottleneck for current cancer nanomedicine, limiting the ultimate antitumor efficacy in the clinic. Herein, by exploiting the well-known instability of indocyanine green (ICG), we report the preparation of near infrared (NIR) light responsive nanoparticles (NP) for enhanced tumor penetration. ICG crosslinks hydroxyethyl starch (HES) and doxorubicin (DOX) conjugates (HES-SS-DOX) via noncovalent interactions, facilitating the formation of ICG@HES-SS-DOX NP. Read More

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http://dx.doi.org/10.1039/c9nr01049aDOI Listing

Development of chlorin e6-conjugated poly(ethylene glycol)-poly(d,l-lactide) nanoparticles for photodynamic therapy.

Nanomedicine (Lond) 2019 Mar 15. Epub 2019 Mar 15.

Department of Pharmacy, Birla Institute of Technology & Science-Pilani, Hyderabad Campus, Jawahar Nagar, Medchal, Hyderabad 500078, Telangana, India.

Aim: In this study, we developed a chlorin e6-conjugated methoxy-poly(ethylene glycol)-poly(d,l-lactide) (mPEG-PLA-Ce6) amphiphilic polymer, which self-assembled to form stable nanoparticles.

Materials & Methods: The nanoparticles were characterized for particle size, ζ-potential and singlet oxygen (O) generation. Cellular internalization and phototoxicity were investigated against monolayer and 3D spheroids of human lung adenocarcinoma cells (A549). Read More

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http://dx.doi.org/10.2217/nnm-2018-0255DOI Listing

Asenapine maleate-loaded nanostructured lipid carriers: optimization and in vitro, ex vivo and in vivo evaluations.

Nanomedicine (Lond) 2019 Mar 15. Epub 2019 Mar 15.

Department of Pharmaceutics, Manipal College of Pharmaceutical Sciences, Manipal Academy of Higher Education, Manipal 576104, Karnataka State, India.

Aim: To prepare nanostructured lipid carriers (NLCs) loaded with asenapine maleate (ASPM) to increase its oral bioavailability by intestinal lymphatic uptake.

Materials & Methods: ASPM-NLCs were prepared by ultrasound dispersion technique, by adopting Design of Experiment approach, and characterized.

Results: The optimized formulation exhibited good physicochemical parameters. Read More

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http://dx.doi.org/10.2217/nnm-2018-0289DOI Listing

Super-resolution microscopy reveals significant impact of M2e-specific monoclonal antibodies on influenza A virus filament formation at the host cell surface.

Sci Rep 2019 Mar 14;9(1):4450. Epub 2019 Mar 14.

Nanoscopy for Nanomedicine Group, Institute for Bioengineering of Catalonia (IBEC), C\Baldiri Reixac 15-21, Helix Building, 08028, Barcelona, Spain.

Influenza A virions are highly pleomorphic, exhibiting either spherical or filamentous morphology. The influenza A virus strain A/Udorn/72 (H3N2) produces copious amounts of long filaments on the surface of infected cells where matrix protein 1 (M1) and 2 (M2) play a key role in virus filament formation. Previously, it was shown that an anti-M2 ectodomain (M2e) antibody could inhibit A/Udorn/72 virus filament formation. Read More

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http://dx.doi.org/10.1038/s41598-019-41023-5DOI Listing

Effect of Nb Substitution on the Structural, Magnetic, and Optical Properties of CoNiFe₂O₄ Nanoparticles.

Nanomaterials (Basel) 2019 Mar 13;9(3). Epub 2019 Mar 13.

Department of Physics, Faculty of Science and Letters, Cukurova University, Balcali-Adana 01330, Turkey.

CoNiNbFeO₄ (0.00 ≤ x ≤ 0.10) nanoparticles (NPs) were prepared using the hydrothermal approach. Read More

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http://dx.doi.org/10.3390/nano9030430DOI Listing

Epilepsy Disease and Nose-to-Brain Delivery of Polymeric Nanoparticles: An Overview.

Pharmaceutics 2019 Mar 13;11(3). Epub 2019 Mar 13.

Department of Drug Sciences, University of Catania; V.le Andrea Doria, 6, 95125 Catania, Italy.

Epilepsy is the fourth most common global neurological problem, which can be considered a spectrum disorder because of its various causes, seizure types, its ability to vary in severity and the impact from person to person, as well as its range of co-existing conditions. The approaches to drug therapy of epilepsy are directed at the control of symptoms by chronic administration of antiepileptic drugs (AEDs). These AEDs are administered orally or intravenously but alternative routes of administration are needed to overcome some important limits. Read More

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http://dx.doi.org/10.3390/pharmaceutics11030118DOI Listing

Nano-Strategies to Target Breast Cancer-Associated Fibroblasts: Rearranging the Tumor Microenvironment to Achieve Antitumor Efficacy.

Int J Mol Sci 2019 Mar 13;20(6). Epub 2019 Mar 13.

Department of Biomedical and Clinical Sciences "L. Sacco", Università degli studi di Milano, via G. B. Grassi 74, 20157 Milano, Italy.

Cancer-associated fibroblasts (CAF) are the most abundant cells of the tumor stroma and they critically influence cancer growth through control of the surrounding tumor microenvironment (TME). CAF-orchestrated reactive stroma, composed of pro-tumorigenic cytokines and growth factors, matrix components, neovessels, and deregulated immune cells, is associated with poor prognosis in multiple carcinomas, including breast cancer. Therefore, beyond cancer cells killing, researchers are currently focusing on TME as strategy to fight breast cancer. Read More

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http://dx.doi.org/10.3390/ijms20061263DOI Listing

A photo-inducible protein-inorganic nanoparticle assembly for active targeted tumour theranostics.

Nanoscale 2019 Mar 14. Epub 2019 Mar 14.

Department of Biochemistry and Molecular Pharmacology and Neurobiology Department, University of Massachusetts Medical School, Worcester, Massachusetts 01605, USA.

The assembly of protein-inorganic nanoparticles is an important yet challenging approach that is utilized to develop functional materials in numerous areas, such as bio-catalysis, drug delivery, and biosensing. In this study, we report on a facile, photo-inducible self-assembly method to generate protein-inorganic hybrid nanoplatforms. More specifically, photo-treated disulfide bond rich proteins of lysozyme (LYS) were able to be used as host materials in order to encapsulate nanoparticles (i. Read More

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http://dx.doi.org/10.1039/c9nr01120jDOI Listing

Pseudo-Wang Handle for the Preparation of Fully Protected Peptides. Synthesis of Liraglutide by Fragment Condensation.

Org Lett 2019 Mar 14. Epub 2019 Mar 14.

CIBER-BBN, Networking Centre on Bioengineering, Biomaterials and Nanomedicine , University of Barcelona , 08028 Barcelona , Spain.

A handle for the protection of the C-terminus of peptides after cleaving with low concentration of trifluoroacetic acid (2-4%) is reported. The handle prevents polymerization reactions in the convergent condensation of peptidic fragments. Moreover, it is traceless, being removed during the final deprotection step of the peptide synthesis. Read More

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http://dx.doi.org/10.1021/acs.orglett.9b00813DOI Listing

Crosslinking catalytic hairpin assembly for high-contrast imaging of multiple mRNAs in living cells.

Chem Commun (Camb) 2019 Mar 14. Epub 2019 Mar 14.

Institute of Chemical Biology and Nanomedicine, State Key Laboratory of Chemo/Bio-Sensing and Chemometrics, College of Chemistry and Chemical Engineering, Hunan University, Changsha 410082, P. R. China.

A novel DNA nanotetrad mediated crosslinking catalytic hairpin assembly (CCHA) is reported to generate clumps of cross-linked mesh products for high-contrast and simultaneous imaging of multiple mRNAs in living cells. Read More

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http://dx.doi.org/10.1039/c9cc01033eDOI Listing

[Pyoderma gangrenosum].

Rev Prat 2018 May;68(5):525

Service de médecine nucléaire, CHU de Besançon, France.

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A Logic-Gated Modular Nanovesicle Enables Programmable Drug Release for On-Demand Chemotherapy.

Theranostics 2019 14;9(5):1358-1368. Epub 2019 Feb 14.

Laboratory of Molecular Imaging and Nanomedicine, National Institute of Biomedical Imaging and Bioengineering, National Institutes of Health, Bethesda, MD 20892, USA.

It remains a major challenge to achieve precise on-demand drug release. Here, we developed a modular nanomedicine integrated with logic-gated system enabling programmable drug release for on-demand chemotherapy. We employed two different logical AND gates consisting of four interrelated moieties to construct the nanovesicles, denoted as v-A-CED, containing oxidation-responsive nanovesicles (v), radical generators (A), and Edman linker conjugated prodrugs (CED). Read More

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http://dx.doi.org/10.7150/thno.32106DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6401502PMC
February 2019

Cationic gold nanoparticles elicit mitochondrial dysfunction: a multi-omics study.

Sci Rep 2019 Mar 13;9(1):4366. Epub 2019 Mar 13.

Nanosafety & Nanomedicine Laboratory, Division of Molecular Toxicology, Institute of Environmental Medicine, Karolinska Institutet, 171 77, Stockholm, Sweden.

Systems biology is increasingly being applied in nanosafety research for observing and predicting the biological perturbations inflicted by exposure to nanoparticles (NPs). In the present study, we used a combined transcriptomics and proteomics approach to assess the responses of human monocytic cells to Au-NPs of two different sizes with three different surface functional groups, i.e. Read More

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http://dx.doi.org/10.1038/s41598-019-40579-6DOI Listing

Amyloid β oligomers suppress excitatory transmitter release via presynaptic depletion of phosphatidylinositol-4,5-bisphosphate.

Nat Commun 2019 Mar 13;10(1):1193. Epub 2019 Mar 13.

Department of Neurobiology, and Department of Ophthalmology of the First Affiliated Hospital, NHC and CAMS Key Laboratory of Medical Neurobiology, Zhejiang University School of Medicine, Hangzhou, 310058, China.

Amyloid β (Aβ) oligomer-induced aberrant neurotransmitter release is proposed to be a crucial early event leading to synapse dysfunction in Alzheimer's disease (AD). In the present study, we report that the release probability (Pr) at the synapse between the Schaffer collateral (SC) and CA1 pyramidal neurons is significantly reduced at an early stage in mouse models of AD with elevated Aβ production. High nanomolar synthetic oligomeric Aβ also suppresses Pr at the SC-CA1 synapse in wild-type mice. Read More

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http://dx.doi.org/10.1038/s41467-019-09114-zDOI Listing

The Position of Inhaled Chemotherapy in the Care of Patients with Lung Tumors: Clinical Feasibility and Indications According to Recent Pharmaceutical Progresses.

Cancers (Basel) 2019 Mar 7;11(3). Epub 2019 Mar 7.

Unité de Pharmacie Galénique et de Biopharmacie, Faculté de Pharmacie, Université libre de Bruxelles (ULB), Brussels 1050, Belgium.

Despite new treatment modalities, including targeted therapies and checkpoint inhibitors, cytotoxic chemotherapy remains central in the care of patients with lung tumors. Use of the pulmonary route to deliver chemotherapy has been proved to be feasible and safe in phase I, Ib/IIa and II trials for lung tumors, with the administration of drug doses to the lungs without prior distribution in the organism. The severe systemic toxicities commonly observed with conventional systemic chemotherapy are consequently reduced. Read More

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http://dx.doi.org/10.3390/cancers11030329DOI Listing

Plasmon-induced optical control over dithionite-mediated chemical redox reactions.

Faraday Discuss 2019 Mar 13. Epub 2019 Mar 13.

NanoPhotonics Centre, Cavendish Laboratory, Department of Physics, University of Cambridge, JJ Thompson Avenue, Cambridge, CB3 0HE, UK.

External-stimuli controlled reversible formation of radical species is of great interest for synthetic and supramolecular chemistry, molecular machinery, as well as emerging technologies ranging from (photo)catalysis and photovoltaics to nanomedicine. Here we show a novel hybrid colloidal system for light-driven reversible reduction of chemical species that, on their own, do not respond to light. This is achieved by the unique combination of photo-sensitive plasmonic aggregates and temperature-responsive inorganic species generating radicals that can be finally accepted and stabilised by non-photo-responsive organic molecules. Read More

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http://dx.doi.org/10.1039/c8fd00155cDOI Listing

Photoinduced Mn doping in cesium lead halide perovskite nanocrystals.

Nanoscale 2019 Mar 13. Epub 2019 Mar 13.

Department of Chemistry, Texas A&M University, College Station, Texas 77843, USA. and Center for Nanomedicine, Institute for Basic Science (IBS), Seoul 03722, Republic of Korea.

We report the photoinduced post-synthesis method of Mn doping in colloidal perovskite nanocrystals, which can produce Mn-doped CsPbX3 (X = Cl, Br) nanocrystals with preserved size and anisotropic morphology. Photoinduced Mn doping occurs through cation exchange driven by the facile photoinduced halide exchange in dihalomethane (CH2X2, X = Cl, Br) solvent taking advantage of in situ photogeneration of halide ions from the solvent molecules. In the presence of a small amount of Mn acetate dissolved in solvent at sub-micromolar concentration, photoexcitation of the nanocrystals above the bandgap initiates the simultaneous anion and cation exchange. Read More

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http://dx.doi.org/10.1039/c8nr10439eDOI Listing

Delivery vehicle of muscle-derived irisin based on silk/calcium silicate/sodium alginate composite scaffold for bone regeneration.

Int J Nanomedicine 2019 22;14:1451-1467. Epub 2019 Feb 22.

Department of Prosthodontics, Shanghai Engineering Research Center of Advanced Dental Technology and Materials, Shanghai Key Laboratory of Stomatology and Shanghai Research Institute of Stomatology, National Clinical Research Center for Oral Diseases, Shanghai Ninth People's Hospital, College of Stomatology, Shanghai Jiao Tong University School of Medicine, Shanghai, China,

Background: Irisin is a cytokine produced by skeletal muscle and usually plays a pivotal role in inducing fat browning and regulating energy expenditure. In recent years, it was found that irisin might be the molecular entity responsible for muscle-bone connectivity and is useful in osteogenesis induction.

Materials And Methods: To study its effect on bone regeneration, we developed silk/calcium silicate/sodium alginate (SCS) composite scaffold based on an interpenetrating network hydrogel containing silk fibroin, calcium silicate, sodium alginate. Read More

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February 2019

Functionalized titanium implant in regulating bacteria and cell response.

Int J Nanomedicine 2019 22;14:1433-1450. Epub 2019 Feb 22.

State Key Laboratory of Military Stomatology & National Clinical Research Center for Oral Diseases & Shaanxi Engineering Research Center for Dental Materials and Advanced Manufacture, Department of Periodontology, School of Stomatology, The Fourth Military Medical University, Xi'an, People's Republic of China,

Background: Biological complications are an issue of critical interest in contemporary dental and orthopedic fields. Although titanium (Ti), graphene oxide (GO) or silver (Ag) particles are suitable for biomedical implants due to their excellent cytocompatibility, bioactivity, and antibacterial properties, the exact antibacterial mechanism is not understood when the three substances are combined (Ti-GO-Ag).

Materials And Methods: In this work, the material characterization, antibacterial property, antibacterial mechanisms, and cell behavior of Ti-GO-Ag fabricated by electroplating and ultraviolet reduction methods respectively, were investigated in detail. Read More

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February 2019

Distribution of SiO nanoparticles in 3D liver microtissues.

Int J Nanomedicine 2019 22;14:1411-1431. Epub 2019 Feb 22.

INM - Leibniz Institute for New Materials, Saarbrücken, Germany,

Introduction: Nanoparticles (NPs) are used in numerous products in technical fields and biomedicine; their potential adverse effects have to be considered in order to achieve safe applications. Besides their distribution in tissues, organs, and cellular localization, their impact and penetration during the process of tissue formation occurring in vivo during liver regeneration are critical steps for establishment of safe nanomaterials.

Materials And Methods: In this study, 3D cell culture of human hepatocarcinoma cells (HepG2) was used to generate cellular spheroids, serving as in vitro liver microtissues. Read More

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http://dx.doi.org/10.2147/IJN.S189888DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6390853PMC
February 2019

Nano-biotechnology: a new approach to treat and prevent malaria.

Int J Nanomedicine 2019 21;14:1401-1410. Epub 2019 Feb 21.

Institute of Chemical Sciences, Gomal University, Dera Ismail Khan, Pakistan.

Malaria, the exterminator of ~1.5 to 2.7 million human lives yearly, is a notorious disease known throughout the world. Read More

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http://dx.doi.org/10.2147/IJN.S190692DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6390872PMC
February 2019

Improving the anti-keloid outcomes through liposomes loading paclitaxel-cholesterol complexes.

Int J Nanomedicine 2019 21;14:1385-1400. Epub 2019 Feb 21.

Klebs Research Center, Department of Dermatology, Yanbian University Hospital, Yanji 133000, China,

Background: Keloids represent benign fibroproliferative tumors which result from elevated expression of inflammation. Paclitaxel (PTX) was an effective chemotherapeutic agent and has been reported to have anti-fibrotic effects, but the strong hydrophobicity brings a challenge for its clinical application.

Purpose: The objective of this study was to improve the water solubility of PTX and investigate its anti-keloid effects. Read More

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February 2019
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Slp-coated liposomes for drug delivery and biomedical applications: potential and challenges.

Int J Nanomedicine 2019 20;14:1359-1383. Epub 2019 Feb 20.

Department of Pharmaceutics, College of Pharmaceutical Science, Zhejiang University of Technology, Hangzhou, Zhejiang, China,

Slp forms a crystalline array of proteins on the outermost envelope of bacteria and archaea with a molecular weight of 40-200 kDa. Slp can self-assemble on the surface of liposomes in a proper environment via electrostatic interactions, which could be employed to functionalize liposomes by forming Slp-coated liposomes for various applications. Among the molecular characteristics, the stability, adhesion, and immobilization of biomacromolecules are regarded as the most meaningful. Read More

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http://dx.doi.org/10.2147/IJN.S189935DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6388732PMC
February 2019

Sustained co-delivery of ibuprofen and basic fibroblast growth factor by thermosensitive nanoparticle hydrogel as early local treatment of peri-implantitis.

Int J Nanomedicine 2019 21;14:1347-1358. Epub 2019 Feb 21.

Department of Polymer Science and Technology and Key Laboratory of Systems Bioengineering of the Ministry of Education, School of Chemical Engineering and Technology, Tianjin University, Tianjin, People's Republic of China,

Objective: The aims of this study were to 1) encapsulate ibuprofen (IBU) and basic fibroblast growth factor (bFGF) in a thermosensitive micellar hydrogel, 2) test the biological properties of this in situ drug delivery system, and 3) study the effect of hydrogel in promoting soft tissue healing after implant surgery and its anti-inflammatory function as an early local treatment of peri-implantitis.

Materials And Methods: A thermosensitive micellar hydrogel was prepared from amphiphilic copolymer poly(ε-caprolactone-co-1,4,8-trioxa [4.6]spiro-9-undecanone)-poly(ethylene glycol)-poly(ε-caprolactone-co-1,4,8-trioxa [4. Read More

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http://dx.doi.org/10.2147/IJN.S190781DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6390857PMC
February 2019
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Starch nanoparticles for delivery of the histone deacetylase inhibitor CG-1521 in breast cancer treatment.

Int J Nanomedicine 2019 20;14:1335-1346. Epub 2019 Feb 20.

Cancer Research Center, Rensselaer, NY 12144, USA,

Background: The efficacy of epigenetic drugs, such as histone deacetylase inhibitors, is often diminished by poor aqueous solubility resulting in limited bioavailability and a low therapeutic index. To overcome the suboptimal therapeutic index, we have developed a biocompatible starch nanoparticle formulation of CG-1521, a histone deacetylase inhibitor in preclinical development for hard-to-treat breast cancers, which improves its bioavailability and half-life.

Methods: The physicochemical parameters (size, zeta potential, morphology, loading, and release kinetics) of these nanoparticles (CG-NPs) have been optimized and their cytotoxic and apoptotic capacities measured in MCF-7 breast cancer cell line. Read More

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http://dx.doi.org/10.2147/IJN.S191837DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6388755PMC
February 2019

3D printing approaches for cardiac tissue engineering and role of immune modulation in tissue regeneration.

Int J Nanomedicine 2019 20;14:1311-1333. Epub 2019 Feb 20.

Department of Stem Cell and Regenerative Biotechnology, Humanized Pig Research Centre (SRC), Konkuk University, Seoul, South Korea,

Conventional tissue engineering, cell therapy, and current medical approaches were shown to be successful in reducing mortality rate and complications caused by cardiovascular diseases (CVDs). But still they have many limitations to fully manage CVDs due to complex composition of native myocardium and microvascularization. Fabrication of fully functional construct to replace infarcted area or regeneration of progenitor cells is important to address CVDs burden. Read More

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http://dx.doi.org/10.2147/IJN.S189587DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6388753PMC
February 2019

Chronic chemotherapy with paclitaxel nanoparticles induced apoptosis in lung cancer in vitro and in vivo.

Int J Nanomedicine 2019 19;14:1299-1309. Epub 2019 Feb 19.

Department of Oncology, The Affiliated Hospital of Southwest Medical University, Luzhou 646000, China,

Aim: Paclitaxel (PTX) is an effective antitumor drug. Previous research demonstrated that paclitaxel nanoparticles (PTX-NPs) exhibited the greatest antitumor effect at 15 hours after light onset (15 HALO), but the mechanism in chronic chemotherapy is still unknown. In our study, we investigated whether PTX-NPs regulated Period2 (Per2) during chronic chemotherapy to induce apoptosis in vivo and in vitro. Read More

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https://www.dovepress.com/chronic-chemotherapy-with-paclitax
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http://dx.doi.org/10.2147/IJN.S188049DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6391150PMC
February 2019
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A novel, self-assembled artificial cartilage-hydroxyapatite conjugate for combined articular cartilage and subchondral bone repair: histopathological analysis of cartilage tissue engineering in rat knee joints.

Int J Nanomedicine 2019 19;14:1283-1298. Epub 2019 Feb 19.

Department of Frontier Medicine, Institute of Medical Science, St Marianna University School of Medicine, Miyamae-ku, Kawasaki 216-8512, Japan,

Purpose: We previously created a self-assembled cartilage-like complex in vitro from only three cartilage components, hyaluronic acid (HA), aggrecan (AG) and type II collagen, without other materials such as cross-linking agents. Based on this self-organized AG/HA/collagen complex, we have created three novel types of biphasic cartilage and bone-like scaffolds combined with hydroxyapatite (HAP) for osteochondral tissue engineering. These scaffolds have been developed from self-assembled cartilage component molecules and HAP at the nanometer scale by manipulating the intermolecular relations. Read More

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http://dx.doi.org/10.2147/IJN.S193963DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6391143PMC
February 2019

Erratum: Diagnosis of rubella virus using antigen-conjugated Au@Pt nanorods as nanozyme probe [Corrigendum].

Authors:

Int J Nanomedicine 2019 19;14:1281. Epub 2019 Feb 19.

[This corrects the article on p. 4795 in vol. 13, PMID: 30197515. Read More

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http://dx.doi.org/10.2147/IJN.S202056DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6391140PMC
February 2019

Modulated electro-hyperthermia-enhanced liposomal drug uptake by cancer cells.

Int J Nanomedicine 2019 18;14:1269-1279. Epub 2019 Feb 18.

Department of Radiation Therapy and Oncology, Shin Kong Wu Ho-Su Memorial Hospital, Taipei, Taiwan,

Purpose: Modulated electro-hyperthermia (mEHT) stands to be a significant technological advancement in the hyperthermia field, utilizing autofocusing electromagnetic power on the cell membrane to create massive apoptosis. Since mEHT possesses the unique ability to excite cell membranes, we hypothesized that mEHT could enhance the uptake of liposomal drugs by enhancing phagocytic activity.

Materials And Methods: Water bath control and mEHT were used to compare the enhancement of liposome-encapsulated doxorubicin (Lipodox) uptake by cancer cells. Read More

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http://dx.doi.org/10.2147/IJN.S188791DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6391149PMC
February 2019

D-α-tocopherol polyethylene glycol 1000 succinate-modified liposomes with an siRNA corona confer enhanced cellular uptake and targeted delivery of doxorubicin via tumor priming.

Int J Nanomedicine 2019 18;14:1255-1268. Epub 2019 Feb 18.

College of Life Science and Technology, Huazhong University of Science and Technology, Wuhan 430074, People's Republic of China,

Background: Combination therapy employing siRNAs and antitumor drugs is a promising method for the treatment of solid tumors. However, regarding combined treatments involving siRNAs and chemotherapeutic reagents, most prior research has focused on the enhanced cytotoxicity against tumor cells conferred by downregulation of the targeted protein.

Purpose: We developed D-α-tocopherol polyethylene glycol 1000 succinate (TPGS)-modified cationic liposomes (LPs) to simultaneously deliver doxorubicin (Dox) and the Bcl-2 siRNA (siBcl-2) for synergistic chemotherapy. Read More

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http://dx.doi.org/10.2147/IJN.S191858DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6391153PMC
February 2019

Magnetic multiwalled carbon nanotubes with controlled release of epirubicin: an intravesical instillation system for bladder cancer.

Int J Nanomedicine 2019 15;14:1241-1254. Epub 2019 Feb 15.

Department of Urology, Shandong Provincial Hospital Affiliated to Shandong University, Jinan 250021, China,

Background: Traditional intravesical instillation treatment in bladder cancer has limited efficacy, which results in a high frequency of recurrence.

Purpose: The aim of this study was to report on an epirubicin (EPI)-loaded magnetic multi-walled carbon nanotube (mMWCNTs-EPI) system for intravesical instillation in place of the current formulation.

Methods: The mMWCNTs-EPI system was formulated with carboxylated MWCNTs, FeO magnetic nanoparticles, and EPI. Read More

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http://dx.doi.org/10.2147/IJN.S189688DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6391142PMC
February 2019
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Systemic exposure to a single dose of ferucarbotran aggravates neuroinflammation in a murine model of experimental autoimmune encephalomyelitis.

Int J Nanomedicine 2019 15;14:1229-1240. Epub 2019 Feb 15.

Department and Graduate Institute of Veterinary Medicine, School of Veterinary Medicine, National Taiwan University, Taipei, Taiwan,

Background: Medicinal preparations of iron oxide nanoparticles (IONPs) have been used as MRI contrast agents for the diagnosis of hepatic tumors and the assessment of neuroinflammation and blood-brain barrier integrity. However, it remains mostly unclear whether exposure to IONPs affects neuroinflammation under disease conditions. The present study aims to investigate the impact of IONPs on autoimmune-mediated neuroinflammation using a murine model of experimental autoimmune encephalomyelitis (EAE) that mimics human multiple sclerosis. Read More

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http://dx.doi.org/10.2147/IJN.S189327DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6391144PMC
February 2019

Energy-dependent endocytosis is responsible for drug transcorneal penetration following the instillation of ophthalmic formulations containing indomethacin nanoparticles.

Int J Nanomedicine 2019 18;14:1213-1227. Epub 2019 Feb 18.

Faculty of Pharmacy, Kindai University, Higashi-Osaka 577-8502, Japan,

Purpose: We previously found that ophthalmic formulations containing nanoparticles prepared by a bead mill method lead to an increase in bioavailability in comparison with traditional formulations (solution type). However, the transcorneal penetration pathway for ophthalmic formulations has not been explained yet. In this study, we investigated the mechanism of transcorneal penetration in the application of ophthalmic formulations containing indomethacin nanoparticles (IMC-NPs). Read More

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http://dx.doi.org/10.2147/IJN.S196681DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6391158PMC
February 2019
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Strategic approach to developing a self-microemulsifying drug delivery system to enhance antiplatelet activity and bioavailability of ticagrelor.

Int J Nanomedicine 2019 15;14:1193-1212. Epub 2019 Feb 15.

College of Pharmacy, Chungnam National University, Daejeon, Republic of Korea,

Background: Ticagrelor (TCG) is used to inhibit platelet aggregation in patients with acute coronary syndrome, but its poor solubility and low bioavailability limit its in vivo efficacy. The purpose of this study was to manufacture an optimized TCG-loaded self-microemulsifying drug delivery system (SMEDDS) to enhance the oral bioavailability and antiplatelet activity of TCG.

Materials And Methods: Solubility and emulsification tests were conducted to determine the most suitable oils, surfactants, and cosurfactants. Read More

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http://dx.doi.org/10.2147/IJN.S190426DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6391151PMC
February 2019