22,114 results match your criteria Nanomedicine [Journal]


Carrier-free nanoparticles of cathepsin B-cleavable peptide-conjugated doxorubicin prodrug for cancer targeting therapy.

J Control Release 2018 Dec 11. Epub 2018 Dec 11.

Biomedical Research Institute, Korea Institute of Science and Technology (KIST), Seoul 02792, Republic of Korea; KU-KIST Graduate School of Converging Science and Technology, Korea University, Seoul, 02841, Republic of Korea. Electronic address:

Cancer nanomedicine using nanoparticle-based delivery systems has shown outstanding promise in recent decades for improving anticancer treatment. However, limited targeting efficiency, low drug loading efficiency and innate toxicity of nanoparticles have caused severe problems, leaving only a few available in the clinic. Here, we newly developed carrier-free nanoparticles of cathepsin B-cleavable peptide (Phe-Arg-Arg-Gly; FRRG)-conjugated doxorubicin (DOX) prodrug (FRRG-DOX) that formed a stable nanoparticle structure with an average diameter of 213 nm in aqueous condition. Read More

View Article
December 2018

Label-free characterization of exosome via surface enhanced Raman spectroscopy for the early detection of pancreatic Cancer.

Nanomedicine 2018 Dec 11. Epub 2018 Dec 11.

Department of Biochemistry and Molecular Biology, University of Nebraska Medical Center, Omaha, NE, USA. Electronic address:

Pancreatic cancer is a highly lethal malignancy. Lack of early diagnostic markers makes timely detection of pancreatic cancer a highly challenging endeavor. Exosomes have emerged as information-rich cancer specific biomarkers. Read More

View Article
December 2018

Combined Raman- and AFM-based detection of biochemical and nanomechanical features of endothelial dysfunction in aorta isolated from ApoE/LDLR-/- mice.

Nanomedicine 2018 Dec 11. Epub 2018 Dec 11.

Institute of Physiology II, University of Münster, Münster, Germany; Institute of Physiology, University of Lübeck, Lübeck, Germany. Electronic address:

Endothelial dysfunction is recognized as a critical condition in the development of cardiovascular disorders. This multifactorial process involves changes in the biochemical and mechanical properties of endothelial cells leading to disturbed release of vasoprotective mediators. Hypercholesterolemia and increased stiffness of the endothelial cortex are independently shown to result in reduced release of nitric oxide and thus endothelial dysfunction. Read More

View Article
December 2018

Modular Nanoparticulate Prodrug Design Enables Efficient Treatment of Solid Tumors Using Bioorthogonal Activation.

ACS Nano 2018 Dec 14. Epub 2018 Dec 14.

Center for Systems Biology , Massachusetts General Hospital , Boston , Massachusetts 02114 , United States.

Prodrug strategies that facilitate localized and controlled activity of small-molecule therapeutics can reduce systemic exposure and improve pharmacokinetics, yet limitations in activation chemistry have made it difficult to assign tunable multifunctionality to prodrugs. Here, we present the design and application of a modular small-molecule caging strategy that couples bioorthogonal cleavage with a self-immolative linker and an aliphatic anchor. This strategy leverages recently discovered in vivo catalysis by a nanoencapsulated palladium compound (Pd-NP), which mediates alloxylcarbamate cleavage and triggers release of the activated drug. Read More

View Article
December 2018

Extracellular Surface Potential Mapping by Scanning Ion Conductance Microscopy Revealed Transient Transmembrane Pore Formation Induced by Conjugated Polymer Nanoparticles.

Macromol Biosci 2018 Dec 13:e1800271. Epub 2018 Dec 13.

Department of Physics, Biomolecular Sciences Institute, Florida International University, FL, 33199, USA.

In-depth understanding of the biophysicochemical interactions at the nano-bio interface is important for basic cell biology and applications in nanomedicine and nanobiosensors. Here, the extracellular surface potential and topography changes of live cell membranes interacting with polymeric nanomaterials using a scanning ion conductance microscopy-based potential imaging technique are investigated. Two structurally similar amphiphilic conjugated polymer nanoparticles (CPNs) containing different functional groups (i. Read More

View Article
December 2018

Welcome to the 14th volume of Nanomedicine.

Authors:
Lucy Chard

Nanomedicine (Lond) 2018 Dec 14. Epub 2018 Dec 14.

Commissioning Editor, Future Medicine, Future Science Group Ltd, London, United Kingdom.

View Article
December 2018

An introduction to zwitterionic polymer behavior and applications in solution and at surfaces.

Chem Soc Rev 2018 Dec 14. Epub 2018 Dec 14.

Manufacturing Business Unit, Commonwealth Scientific and Industrial Research Organisation, Bayview Avenue, Clayton, VIC 3168, Australia.

Zwitterionic polymers, including polyampholytes and polybetaines, are polymers with both positive and negative charges incorporated into their structure. They are a unique class of smart materials with great potential in a broad range of applications in nanotechnology, biomaterials science, nanomedicine and healthcare, as additives for bulk construction materials and crude oil, and in water remediation. In this Tutorial Review, we aim to highlight their structural diversity and design criteria, and their preparation using modern techniques. Read More

View Article
December 2018

Ethyl violet-bovine serum albumin fluorescent protein nanovessels target to lysosomes and mitochondria.

Nanomedicine (Lond) 2018 Dec 14. Epub 2018 Dec 14.

State Key Laboratory of Supramolecular Structure & Materials & Institute of Theoretical Chemistry, Jilin University, 2699 Qianjin Street, Changchun 130012, PR China.

Aim: Organelles are essential in maintaining homeostasis of mammalian cells. Monitoring the morphology and dynamics of organelles is of significance in cell state determination and disease diagnosis.

Materials & Methods: We describe here a new material called ethyl violet-bovine serum albumin fluorescent protein nanovessel (EV-BSA FPN). Read More

View Article
December 2018

Methods for Assessing Mast Cell Responses to Engineered Nanomaterial Exposure.

Methods Mol Biol 2019 ;1894:31-45

Department of Pharmaceutical Sciences, Colorado Center for Nanomedicine and Nanosafety, Skaggs School of Pharmacy and Pharmaceutical Sciences, University of Colorado, Aurora, CO, USA.

Mast cells are key effector cells in inflammatory and allergic immune responses such as asthma, rhinitis, and atopic dermatitis. Activation of mast cells leads to immediate release of preformed mediators such as histamine and proteases, which can regulate vascular permeability and the function of a number of immune and nonimmune cells. Engineered nanomaterials (ENM) have been utilized for a wide range of applications and introduced into a number of consumer products; yet the consequent increase in human exposure and any potential adverse effects have not been fully evaluated. Read More

View Article
January 2019

Advanced applications of nanotechnology in veterinary medicine.

Environ Sci Pollut Res Int 2018 Dec 13. Epub 2018 Dec 13.

Faculty of Veterinary Medicine, Department of Medicine and Infectious Diseases, Cairo University, Giza, Egypt.

The invention of new techniques to manipulate materials at their nanoscale had an evolutionary effect on various medical sciences. At the time, there are thousands of nanomaterials which can be divided according to their shape, origin, or their application. The nanotechnology provided new solutions for old problems. Read More

View Article
December 2018
1 Read

The availability of drug by liposomal drug delivery : Individual kinetics and tissue distribution of encapsulated and released drug in mice after administration of PEGylated liposomal prednisolone phosphate.

Invest New Drugs 2018 Dec 13. Epub 2018 Dec 13.

Department of Clinical Pharmacy, Division of Laboratory Medicine & Pharmacy, University Medical Centre Utrecht, Utrecht, The Netherlands.

Lately, the usefulness of liposomal drug delivery systems has been debated. To better understand the underlying pharmacokinetics of the targeted drug delivery by liposomes, individual encapsulated and non-encapsulated drug concentrations in blood, tumor, liver, spleen and kidneys were quantified after i.v. Read More

View Article
December 2018

Perfluorophenyl Derivatives as Unsymmetrical Linkers for Solid Phase Conjugation.

Front Chem 2018 28;6:589. Epub 2018 Nov 28.

School of Chemistry and Physics, University of KwaZulu-Natal, Durban, South Africa.

Linkers play major roles in conjugation chemistry toward the advancement of drug discovery. Two different series of fluorinated linkers were introduced to the backbone of a model peptide using solid phase peptide synthesis. These fluorinated linkers have the potential to conjugate two asymmetrical groups. Read More

View Article
November 2018

The multikinase inhibitor regorafenib decreases angiogenesis and improves portal hypertension.

Oncotarget 2018 Nov 16;9(90):36220-36237. Epub 2018 Nov 16.

Department of Internal Medicine I, University of Bonn, Bonn, Germany.

Background And Aims: Angiogenesis is critically involved in the development of liver fibrosis, portal hypertension (PHT) and hepatocellular carcinoma (HCC). Regorafenib is a novel second-line therapy for HCC, but might also be beneficial in fibrosis and PHT even in absence of HCC. This study investigated the effects of regorafenib in experimental models without HCC. Read More

View Article
November 2018

Overview of DNA Self-Assembling: Progresses in Biomedical Applications.

Pharmaceutics 2018 Dec 11;10(4). Epub 2018 Dec 11.

Institute for Advanced Chemistry of Catalonia (IQAC-CSIC), Networking Center on Bioengineering, Biomaterials and Nanomedicine (CIBER-BBN), Jordi Girona 18-26, E-08034 Barcelona, Spain.

Molecular self-assembling is ubiquitous in nature providing structural and functional machinery for the cells. In recent decades, material science has been inspired by the nature's assembly principles to create artificially higher-order structures customized with therapeutic and targeting molecules, organic and inorganic fluorescent probes that have opened new perspectives for biomedical applications. Among these novel man-made materials, DNA nanostructures hold great promise for the modular assembly of biocompatible molecules at the nanoscale of multiple shapes and sizes, designed via molecular programming languages. Read More

View Article
December 2018

Spectrum-Effect Relationships between High-Performance Liquid Chromatography (HPLC) Fingerprints and the Antioxidant and Anti-Inflammatory Activities of Collagen Peptides.

Molecules 2018 Dec 10;23(12). Epub 2018 Dec 10.

College of Life Science and Technology, Huazhong University of Science and Technology, Wuhan 430074, China.

A total of 13 batches of collagen peptide samples were extracted, isolated, and purified from chicken sternal cartilage under various process parameters. The fingerprint profiles of 13 batches of collagen peptides were established by high-performance liquid chromatography (HPLC). In addition, the amino acid profiles and molecular weight distributions of collagen peptides were investigated. Read More

View Article
December 2018
1 Read

Composite scaffold obtained by electro-hydrodynamic technique for infection prevention and treatment in bone repair.

Int J Pharm 2018 Dec 10. Epub 2018 Dec 10.

Department of Chemical Engineering, Aragon Institute of Nanoscience (INA), University of Zaragoza, Campus Rio Ebro-Edificio I+D, C/ Mariano Esquillor S/N, 50018 Zaragoza, Spain; Aragon Health Research Institute (IIS Aragon), 50009 Zaragoza, Spain. Electronic address:

Bone infection is a devastating condition resulting from implant or orthopaedic surgery. Therapeutic strategies are extremely complicated and may result in serious side effects or disabilities. The development of enhanced 3D scaffolds, able to promote efficient bone regeneration, combined with targeted antibiotic release to prevent bacterial colonization, is a promising tool for the successful repair of bone defects. Read More

View Article
December 2018

Noninvasive biodegradable nanoparticles-in-nanofibers single-dose ocular insert: in vitro, ex vivo and in vivo evaluation.

Nanomedicine (Lond) 2018 Dec 13. Epub 2018 Dec 13.

Nanomaterials Lab, Center of Material Science (CMS), Zewail City of Science & Technology, 6th of October, Giza 12578, Egypt.

Aim: This study involves, for the first time, the development of mucoadhesive biodegradable polymeric-multilayered nanoparticles-in-nanofibers (NPs-in-NFs) matrix as an innovative single-dose noninvasive ocular-insert that could substitute conventional ocular dosage-forms.

Materials & Methods: Azithromycin-loaded poly(lactic-co-glycolic acid) copolymer/pluronic NPs were developed then incorporated into electrospun polyvinylpyrrolidone NFs, and tested for their efficient treatment of ocular bacterial infection.

Results: Release and permeation studies proved the ability of the insert to control drug release over 10 days. Read More

View Article
December 2018

Multifunctional Two-Dimensional Core-Shell MXene@Gold Nanocomposites for Enhanced Photo-Radio Combined Therapy in the Second Biological Window.

ACS Nano 2018 Dec 13. Epub 2018 Dec 13.

Multi-functional nanoplatforms with special advantages in the diagnosis and treatment of cancer have been widely explored in nanomedicine. Herein, we synthesize two-dimensional core-shell nanocomposites (Ti3C2@Au) via a seed-growth method starting from the titanium carbide (Ti3C2) nanosheets, a classical type of MXene nanostructure. After growing gold on the surface of Ti3C2 nanosheets, the stability and biocompatibility of the nanocomposites are greatly improved by the thiol modification. Read More

View Article
December 2018

Exploring an interesting dual functionality of anacardic acid for efficient paclitaxel delivery in breast cancer therapy.

Nanomedicine (Lond) 2018 Dec 13. Epub 2018 Dec 13.

Department of Pharmaceutics, Centre for Pharmaceutical Nanotechnology, National Institute of Pharmaceutical Education & Research (NIPER), Sector 67, S.A.S. Nagar (Mohali), Punjab 160062, India.

Aim: To explore the potential of paclitaxel (PTX)-loaded anacardic acid conjugated hydrophobized gelatin nanoparticles.

Materials & Methods: Nanoparticles prepared by nanoprecipitation technique were evaluated for various quality attributes (particle size, % entrapment efficiency) in vitro drug release, MCF-7 cell uptake, cell cytotoxicity, in vivo pharmacokinetics, antitumor efficacy and toxicity.

Results: The nanoparticles (250-300 nm, 74% entrapment efficiency) showed approximately 2. Read More

View Article
December 2018

Enhanced combination cancer therapy using lipid-calcium carbonate/phosphate nanoparticles as a targeted delivery platform.

Nanomedicine (Lond) 2018 Dec 13. Epub 2018 Dec 13.

Australian Institute for Bioengineering & Nanotechnology, The University of Queensland, St Lucia, QLD 4072, Australia.

Aim: Melanoma, the most life-threatening skin cancer, requires more effective therapies.

Methodology: A new folic acid (FA) receptor-targeted lipid-coated calcium carbonate/phosphate (LCCP) nanoparticle was synthesized, incorporating two often-used therapeutics, cell death siRNA and α-tocopheryl succinate.

Results: The nanoparticles were spherical, with an average size of 40 nm. Read More

View Article
December 2018

Targeting Inflammation With Nanosized Drug Delivery Platforms in Cardiovascular Diseases: Immune Cell Modulation in Atherosclerosis.

Front Bioeng Biotechnol 2018 27;6:177. Epub 2018 Nov 27.

NEST Laboratory, Scuola Normale Superiore, Pisa, Italy.

Atherosclerosis (AS) is a disorder of large and medium-sized arteries; it consists in the formation of lipid-rich plaques in the intima and inner media, whose pathophysiology is mostly driven by inflammation. Currently available interventions and therapies for treating atherosclerosis are not always completely effective; side effects associated with treatments, mainly caused by immunodepression for anti-inflammatory molecules, limit the systemic administration of these and other drugs. Given the high degree of freedom in the design of nanoconstructs, in the last decades researchers have put high effort in the development of nanoparticles (NPs) formulations specifically designed for either drug delivery, visualization of atherosclerotic plaques, or possibly the combination of both these and other functionalities. Read More

View Article
November 2018

Cognitive impairments induced by necrotizing enterocolitis can be prevented by inhibiting microglial activation in mouse brain.

Sci Transl Med 2018 Dec;10(471)

Division of General Pediatric Surgery, Johns Hopkins University and Bloomberg Children's Center, Johns Hopkins Hospital, Baltimore, MD 21287, USA.

Necrotizing enterocolitis (NEC) is a severe gastrointestinal disease of the premature infant. One of the most important long-term complications observed in children who survive NEC early in life is the development of profound neurological impairments. However, the pathways leading to NEC-associated neurological impairments remain unknown, thus limiting the development of prevention strategies. Read More

View Article
December 2018
15.843 Impact Factor

Predicting strain engineering strategies using iKS1317: a genome-scale metabolic model of Streptomyces coelicolor.

Biotechnol J 2018 Dec 7:e1800180. Epub 2018 Dec 7.

Department of Biotechnology and Food Science, NTNU - Norwegian University of Science and Technology, Trondheim, Norway.

Streptomyces coelicolor is a model organism for the Actinobacteria, a phylum known to produce an extensive range of different bioactive compounds that include antibiotics currently used in the clinic. Biosynthetic gene clusters discovered in genomes of other Actinobacteria can be transferred to and expressed in S. coelicolor, making it a factory for heterologous production of secondary metabolites. Read More

View Article
December 2018

An in situ assembly strategy for the construction of a sensitive and reusable electrochemical aptasensor.

Chem Commun (Camb) 2018 Dec 7. Epub 2018 Dec 7.

MOE Key Laboratory of Analysis and Detection for Food Safety, Fujian Provincial Key Laboratory of Analysis and Detection Technology for Food Safety, Institute of Nanomedicine and Nanobiosensing, College of Chemistry, Fuzhou University, Fuzhou, 350116, China.

The 5'-end thiolated aptamer is attached on the electrode surface through hybridization with immobilized assistant strands. Then the signal enhancing platform of gold nanoparticles and an electroactive Cu2+-l-cysteine tag are in situ tethered on the 5'-end of the aptamer, through which, a sensitive and reusable aptasensor is facilely constructed. Read More

View Article
December 2018

Resveratrol Brain Delivery for Neurological Disorders Prevention and Treatment.

Front Pharmacol 2018 20;9:1261. Epub 2018 Nov 20.

LEPABE, Department of Chemical Engineering, Faculty of Engineering of the University of Porto, Porto, Portugal.

Resveratrol (RES) is a natural polyphenolic non-flavonoid compound present in grapes, mulberries, peanuts, rhubarb and in several other plants. Numerous health effects have been related with its intake, such as anti-carcinogenic, anti-inflammatory and brain protective effects. The neuroprotective effects of RES in neurological diseases, such as Alzheimer's (AD) and Parkinson's (PD) diseases, are related to the protection of neurons against oxidative damage and toxicity, and to the prevention of apoptotic neuronal death. Read More

View Article
November 2018

GQDs-MSNs nanocomposite nanoparticles for simultaneous intracellular drug delivery and fluorescent imaging.

J Nanopart Res 2018 17;20(11):306. Epub 2018 Nov 17.

1NanoBioMedical Centre, Adam Mickiewicz University in Poznań, Umultowska 85, 61-614 Poznań, Poland.

Although number of stimuli-responsive drug delivery systems based on mesoporous silica nanoparticles (MSNs) have been developed, the simultaneous real-time monitoring of carrier in order to guarantee proper drug targeting still remains as a challenge. GQDs-MSNs nanocomposite nanoparticles composed of graphene quantum dots (GQDs) and MSNs are proposed as efficient doxorubicin delivery and fluorescent imaging agent, allowing to monitor intracellular localization of a carrier and drug diffusion route from the carrier. Graphene quantum dots (average diameter 3. Read More

View Article
November 2018

Aptamer-conjugated multi-walled carbon nanotubes as a new targeted ultrasound contrast agent for the diagnosis of prostate cancer.

J Nanopart Res 2018 12;20(11):303. Epub 2018 Nov 12.

2Department of Pharmacy, Changhai Hospital, Second Military Medical University, No. 168 Changhai Road, Yangpu District, Shanghai, 200092 China.

Early diagnosis is primarily important for the therapeutic and prognostic outcomes of malignancies including prostate cancer (PCa). However, the visuality and veracity of ultrasound imaging for the diagnosis and prognostic prediction of PCa remains poor at present. In this study, we developed a new nanoultrasound contrast agent by modifying multi-walled carbon nanotubes (MWCNTs) with polyethylene glycol (PEG) and anti-PSMA aptamer. Read More

View Article
November 2018

A naphthalene-based fluorescent probe for ratiometric imaging of lysosomal hydrogen sulfide in living cells.

Methods Appl Fluoresc 2018 Oct 19. Epub 2018 Oct 19.

State Key Laboratory of Chemo/Bio-sensing & Chemometrics, College of Chemistry & Chemical Engineering, Hunan University, Changsha, 410082, CHINA.

Hydrogen sulfide is an important gasotransmitter that exhibits various functions in physiological processes. We present a ratiometric fluorescence probe (SN-N3) for H2S by functionalizing naphthalene imide with 4-(azidomethyl)benzene as a H2S recognition moiety and a morpholine moiety as a lysosomal targeting unit. After reaction with H2S, the azido moiety is reduced to amine group, and the probe releases the self-immolative linker and regenerates the fluorophore with internal charge transfer effect. Read More

View Article
October 2018

Blindness as an uncommon complication of Streptococcus pneumoniae systemic infection.

Intensive Care Med 2018 Dec 6. Epub 2018 Dec 6.

Faculté de Médecine, Hôpitaux universitaires de Strasbourg, Service de Réanimation Médicale, Nouvel Hôpital Civil, Université de Strasbourg (UNISTRA), 1 place de l'Hôpital, 67000, Strasbourg, France.

View Article
December 2018

Combinatory Cancer Therapeutics with Nanoceria-capped Mesoporous Silica Nanocarriers Through pH-triggered Drug Release and Redox Activity.

ACS Appl Mater Interfaces 2018 Dec 12. Epub 2018 Dec 12.

In the field of nanomedicine, drug-loaded nanocarriers that integrate nanotechnology and chemotherapeutics are widely used to achieve synergistic therapeutic effects. Here we prepared mesoporous silica nanoparticles capped with cerium oxide nanoparticles (COP@MSN) where a pH triggered-responsive mechanism was used to control drug release and intracellular drug delivery. We blocked the mesopores of the carboxyl functionalized MSN with aminated COP. Read More

View Article
December 2018

Apically targeted oral micelles exhibit highly efficient intestinal uptake and oral absorption.

Int J Nanomedicine 2018 26;13:7997-8012. Epub 2018 Nov 26.

School of Chinese Materia Medica, Modern Research Center for Traditional Chinese Medicine, Beijing University of Chinese Medicine, Beijing, 100029, China,

Introduction: Polymeric micelles (PMs) hold promise for improving solubility and oral absorption of poorly soluble drugs. Unfortunately, the oral absorption of PMs is also limited by intestinal epithelium. To improve the oral delivery efficiency of micelles, transporter-mediated micelles could enhance the transport efficiency across the epithelial barrier, and they have attracted more attention. Read More

View Article
November 2018

Sub-10 nm CuFeS cube for magnetic resonance imaging-guided photothermal therapy of cancer.

Int J Nanomedicine 2018 26;13:7987-7996. Epub 2018 Nov 26.

Department of Orthopedics, The First People's Hospital of Shangqiu, Shangqiu, Henan 476000, China.

Background: Facile synthesis and small size theranostic agents have shown great potential for cancer diagnosis and treatment.

Purpose: A ternary compound (CuFeS), Fe doped copper sulfide, with novel magnetic properties and strong near-infrared absorption was prepared for magnetic resonance imaging (MRI) imaging guided photothermal therapy of cancer.

Patients And Methods: Firstly, the capability of magnetic resonance imaging based on the novel magnetic properties and the photothermal performance due to the strong near-infrared absorption was investigated in vitro. Read More

View Article
November 2018

Safe decontamination of cytostatics from the nitrogen mustards family. Part one: cyclophosphamide and ifosfamide.

Int J Nanomedicine 2018 26;13:7971-7985. Epub 2018 Nov 26.

Department of Oncology, 1st Faculty of Medicine, Charles University and General University Hospital in Prague, Prague, Czech Republic,

Introduction: Macrocrystalline oxides of alkaline earth metals (Mg and Ca) or light metals (Al and Ti) can respond to standard warfare agents such as sulfur mustard, soman, or agent VX. In this paper, we compared the decontamination ability of sodium hydroxide (NaOH) and sodium hypochlorite (NaClO) for nitrogen mustards (cyclophosphamide [CP] and ifosfamide [IFOS]) with a new procedure using a destructive sorbent based on nanocrystalline and nanodispersive titanium dioxide (TiO) as a new efficient and cheap material for complete decontamination of surfaces.

Methods: Titanium (IV) dioxide nanoparticles were prepared by the homogeneous hydrolysis of titanium(IV) oxysulfate (TiOSO) with urea. Read More

View Article
November 2018

Novel application of trimethyl chitosan as an adjuvant in vaccine delivery.

Int J Nanomedicine 2018 23;13:7959-7970. Epub 2018 Nov 23.

Molecular Biology and Genetic Engineering Laboratory, School of Biotechnology, Jawaharlal Nehru University, New Delhi, India,

The application of natural carbohydrate polysaccharides for antigen delivery and its adjuvanation potential has garnered interest in the scientific community in the recent years. These biomaterials are considered favorable candidates for adjuvant development due to their desirable properties like enormous bioavailability, non-toxicity, biodegradability, stability, affordability, and immunostimulating ability. Chitosan is the one such extensively studied natural polymer which has been appreciated for its excellent applications in pharmaceuticals. Read More

View Article
November 2018

Potential effects of different natural antioxidants on inflammatory damage and oxidative-mediated hepatotoxicity induced by gold nanoparticles.

Int J Nanomedicine 2018 23;13:7931-7938. Epub 2018 Nov 23.

Department of Physics and Astronomy, College of Science, King Saud University, Riyadh, Saudi Arabia,

Objective: The objective of this study was to verify and confirm the oxidative-mediated hepatotoxicity, inflammatory liver damage, and oxidative stress induced by intraperitoneal administration of gold nanoparticles (GNPs) in vivo; characterize the effect of different natural antioxidants on these hazardous changes; and finally choose the most powerful antioxidant among these different natural antioxidants.

Methods: Ten-nanometer GNPs were dissolved in aqueous solution of 0.01% concentration. Read More

View Article
November 2018

Vascular targeted nanotherapeutic approach for obesity treatment.

Int J Nanomedicine 2018 23;13:7915-7929. Epub 2018 Nov 23.

Department of Science and Technology/Mintek Nanotechnology Innovation Centre, Biolabels Unit, Department of Biotechnology, University of the Western Cape, Bellville, South Africa,

Obesity is a global epidemic that poses a serious health concern due to it being a risk factor for life-threatening chronic diseases, such as type 2 diabetes, cancer, and cardiovascular diseases. Pharmacotherapy remains the mainstay for the management of obesity; however, its usefulness is limited due to poor drug efficacy, non-specificity and toxic side effects. Therefore, novel approaches that could provide insights into obesity and obesity-associated diseases as well as development of novel anti-obesity treatment modalities or improvement on the existing drugs are necessary. Read More

View Article
November 2018

Macrophage uptake switches on OCT contrast of superparamagnetic nanoparticles for imaging of atherosclerotic plaques.

Int J Nanomedicine 2018 23;13:7905-7913. Epub 2018 Nov 23.

Department of Radiology, Charité-Universitätsmedizin Berlin, Germany,

Background: Optical coherence tomography (OCT) is an intravascular, high-resolution imaging technique that is used to characterize atherosclerotic plaques. However, the identification of macrophages as important markers of inflammation and plaque vulnerability remains difficult. Here, we investigate whether the uptake of very small iron oxide particles (VSOP) in macrophages, that cluster in phagolysosomes and allow high-quality magnetic resonance imaging (MRI) of atherosclerotic plaques, and uptake of ferumoxytol nanoparticles enhance detection of macrophages by OCT. Read More

View Article
November 2018

Electrospun nanofiber blend with improved mechanical and biological performance.

Int J Nanomedicine 2018 22;13:7891-7903. Epub 2018 Nov 22.

Division of Engineering in Medicine, Department of Medicine, Brigham and Women's Hospital, Harvard Medical School, Cambridge, MA 02139, USA,

Background: Here, electrospun fibers based on a blend of polycaprolactone (PCL), poly(ethylene glycol) (PEG), and gelatin methacryloyl (GelMA) were developed. The careful choice of this polymer combination allowed for the preparation of a biomaterial that preserved the mechanical strength of PCL, while at the same time improving the hydrophilicity of the blended material and human osteoblast maturation.

Methods: The morphology, chemical structure, wettability, and mechanical properties before and after UV photocrosslinking were evaluated. Read More

View Article
November 2018

Fabrication and evaluation of a γ-PGA-based self-assembly transferrin receptor-targeting anticancer drug carrier.

Int J Nanomedicine 2018 22;13:7873-7889. Epub 2018 Nov 22.

School of Life Sciences, East China Normal University, Shanghai 200241, China,

Background: cis-Dichlorodiamineplatinum (CDDP) was one of the most common used drugs in clinic for cancer treatment. However, CDDP caused a variety of side effects. The abundant carboxyl groups on the surface of poly glutamic acid (PGA) could be modified with various kinds of targeted ligands. Read More

View Article
November 2018

Targeted delivery of reduced graphene oxide nanosheets using multifunctional ultrasound nanobubbles for visualization and enhanced photothermal therapy.

Int J Nanomedicine 2018 22;13:7859-7872. Epub 2018 Nov 22.

Department of Ultrasound, Harbin Medical University Cancer Hospital, Nangang District, Harbin 150080, China,

Ultrasound molecular imaging as a promising strategy, which involved the use of molecularly targeted contrast agents, combined the advantages of contrast-enhanced ultrasound with the photothermal effect of reduced graphene oxide (rGO).

Methods And Results: The heparin sulfate proteoglycan glypican-3 (GPC3) is a potential molecular target for hepatocellular carcinoma (HCC). In this study, we covalently linked biotinylated GPC3 antibody to PEGylated nano-rGO to obtain GPC3-modified rGO-PEG (rGO-GPC3), and then combined rGO-GPC3 with avidinylated nanobubbles (NBs) using biotin-avidin system to prepare NBs-GPC3-rGO with photothermal effect and dispersibility, solubility in physiological environment. Read More

View Article
November 2018

Mechanism research on a bioactive resveratrol- PLA-gelatin porous nano-scaffold in promoting the repair of cartilage defect.

Int J Nanomedicine 2018 22;13:7845-7858. Epub 2018 Nov 22.

Department of Orthopedics and Trauma, Peking University People's Hospital, Beijing, China,

Background: Articular cartilage defects are difficult to treat, but drug-loaded tissue engineering scaffolds provide a possible treatment option for these types of injuries.

Purpose: In this study, we designed a bioactive resveratrol-PLA-gelatin porous nano-scaffold using electrospinning, freeze drying, and uniform dispersion techniques to repair articular cartilage defects, and then investigated the possible mechanism behind the successful repair.

Methods: We established an articular cartilage defect rat model with a 2 mm diameter wound in the middle of the knee joint femoral condyle non-weight-bearing area, with a depth reaching the full thickness of the subchondral bone. Read More

View Article
November 2018

Dimethyl 2,2'-[2,2'-(ethane-1,1-diyl)bis(1-indole-3,2-diyl)]-diacetate: a small molecule capable of nano-scale assembly, inhibiting venous thrombosis and inducing no bleeding side effect.

Int J Nanomedicine 2018 22;13:7835-7844. Epub 2018 Nov 22.

Beijing Area Major Laboratory of Peptide and Small Molecular Drugs, School of Pharmaceutical Sciences, Capital Medical University, Beijing 100069, China,

Background: Due to the discovery that deep venous thrombosis (DVT) inhibitor is of chemotherapeutic importance, the nano-property of dimethyl 2,2'-[2,2'-(ethane-1,1-diyl) bis(1-indole-3,2-diyl)]-diacetate (DEBIC), a recently reported antitumor agent, is worthy of characterization.

Materials And Methods: One-pot reaction was used to prepare DEBIC. Electrospray Ionization (+/-)-Fourier Transform-Ion Cyclotron Resonance-Mass Spectrometer (ESI(+/-)-FT-ICR-MS), quadrupole Collision Induced Dissociation (qCID) and nuclear overhauser effect spectroscopy spectra were used to present the assembly of DEBIC. Read More

View Article
November 2018

Co-exposure subacute toxicity of silica nanoparticles and lead acetate on cardiovascular system.

Int J Nanomedicine 2018 21;13:7819-7834. Epub 2018 Nov 21.

Department of Toxicology and Sanitary Chemistry, School of Public Health, Capital Medical University, Beijing 100069, PR China,

Background: The harmful effects following the release of nanomaterials into environment are of great concern today.

Purpose: In this study, subacute effect due to co-exposure to low-dose silica nanoparticles (SiNPs) and lead acetate (Pb) on cardiovascular system was detected in Sprague Dawley male rats.

Materials And Methods: Histopathological and ultrastructural changes of heart, aortic arch and abdominal aorta were detected. Read More

View Article
November 2018
1 Read

A Zr-labeled lipoplex nanosystem for image-guided gene delivery: design, evaluation of stability and in vivo behavior.

Int J Nanomedicine 2018 21;13:7801-7818. Epub 2018 Nov 21.

Drug Discovery and Development Research Group, College of Pharmacy and Nutrition, University of Saskatchewan, Saskatoon, SK S7N 5E5, Canada,

Background: With the advances in radiopharmaceutical research, the development of image-guided therapy has become a major interest. While the development of theranostic nanotherapeutics is frequently associated with cancer chemotherapy, phototherapy and radiotherapy, there is little information available on the in vivo monitoring of gene delivery systems and the application of image-guided approach in gene therapy. The goal of this work was to determine the in vivo behavior of DNA delivery nanosystems - based on cationic gemini surfactants - designed for image-guided gene therapy. Read More

View Article
November 2018

Biogenic pentagonal silver nanoparticles for safer and more effective antibacterial therapeutics.

Int J Nanomedicine 2018 21;13:7789-7799. Epub 2018 Nov 21.

Nanomedicine & Nanobiotechnology Lab, Department of Biosciences, Integral University, Dasauli, Lucknow, India,

Background: Biological synthesis of nanomaterials possesses unprecedented potential in the production of nanomaterials due to their ability to produce nanomaterials with improved biocompatibility in addition to eco-friendly synthetic procedures.

Methods: This article reports the isolation of an air-borne fungus from the campus of Integral University, Lucknow, with an exceptional ability to withstand very high concentrations of silver salt. The fungus was found to produce pentagonal silver nanoparticles (AgPgNps) when silver ions were reduced from silver nitrate. Read More

View Article
November 2018

Nitric oxide-releasing nanoparticles improve doxorubicin anticancer activity.

Int J Nanomedicine 2018 20;13:7771-7787. Epub 2018 Nov 20.

Department of Drug Science, University of Catania, Catania, Italy.

Purpose: Anticancer drug delivery systems are often limited by hurdles, such as off-target distribution, slow cellular internalization, limited lysosomal escape, and drug resistance. To overcome these limitations, we have developed a stable nitric oxide (NO)-releasing nanoparticle (polystyrene-maleic acid [SMA]--dodecane S-nitrosothiol [tDodSNO]) with the aim of enhancing the anticancer properties of doxorubicin (Dox) and a Dox-loaded nanoparticle (SMA-Dox) carrier.

Materials And Methods: Effects of SMA-tDodSNO and/or in combination with Dox or SMA-Dox on cell viability, apoptosis, mitochondrial membrane potential, lysosomal membrane permeability, tumor tissue, and tumor growth were studied using in vitro and in vivo model of triple-negative breast cancer (TNBC). Read More

View Article
November 2018

Effects of quercetin and arginine on the nephrotoxicity and lipid peroxidation induced by gold nanoparticles in vivo.

Int J Nanomedicine 2018 21;13:7765-7770. Epub 2018 Nov 21.

Department of Physics and Astronomy, College of Science, King Saud University, Riyadh, Saudi Arabia,

Introduction: This study aimed to evaluate the nephrotoxicity caused by gold nanoparticles (GNPs) and investigate the potential roles of quercetin (Qur) and arginine (Arg) in mitigating the inflammatory kidney damage and dysfunction and inhibiting the toxicity induced by GNPs in rats.

Methods: Kidney function was assessed using various serum biomarkers, including blood urea nitrogen (BUN), uric acid (URIC), and creatinine (CR), while toxicity was evaluated by measuring the biomarkers glutathione (GSH) and malondialdehyde (MDA) in kidney tissues.

Results: Administration of GNPs to the rats severely affected the serum kidney biomarkers, as confirmed by the notable increases in BUN, URIC, and CR. Read More

View Article
November 2018

Recent advances in ultrasound-based transdermal drug delivery.

Int J Nanomedicine 2018 20;13:7749-7763. Epub 2018 Nov 20.

School of Chemistry, Monash University, Clayton, VIC 3800, Australia,

The transdermal transport of pharmaceuticals possesses various advantageous properties over conventional drug administration techniques such as oral delivery and hypodermic injections. However, the stratum corneum persists as the main barrier, which impedes percutaneous transport. The ultrasound-based transdermal delivery of therapeutics is one of the techniques that are being investigated to overcome this obstacle. Read More

View Article
November 2018

Exosome-mediated delivery of functionally active miRNA-142-3p inhibitor reduces tumorigenicity of breast cancer in vitro and in vivo.

Int J Nanomedicine 2018 20;13:7727-7747. Epub 2018 Nov 20.

Department of Medical Biotechnology, Faculty of Medical Sciences, Tarbiat Modares University, Tehran, Iran,

Background: Exosomes, widely recognized natural nanovesicles, represent one of the recently discovered modes of intercellular communication due to their ability to transmit crucial cellular information that can be engineered to have robust delivery and targeting capacity. MiR-142-3p, one of the upregulated microRNAs (miRNAs) in many types of breast cancer, activates the canonical Wnt signaling pathway and transactivates the miR-150 expression, and results in the hyperproliferation of cancer cells in vitro and mammary glands in vivo.

Materials And Methods: In this study, we exploited the exosomes isolated from bone marrow-derived mesenchymal stem cells (MSCs-Exo) to deliver LNA (locked nucleic acid)-modified anti-miR-142-3p oligonucleotides to suppress the expression level of miR-142-3p and miR-150 in 4T1 and TUBO breast cancer cell lines. Read More

View Article
November 2018
1 Read

Lipid surface modifications increase mesoporous silica nanoparticle labeling properties in mesenchymal stem cells.

Int J Nanomedicine 2018 20;13:7711-7725. Epub 2018 Nov 20.

Department of Instructive Biomaterials Engineering, MERLN Institute for Technology-Inspired Regenerative Medicine, Maastricht University, 6229 ER MD, Maastricht, the Netherlands,

Background: Nanoparticles have emerged as promising cell-labeling tools, as they can be precisely tailored in terms of chemical and physical properties. Mesoporous silica nanoparticles (MSNs), in particular, are easily tunable with regard to surface and core chemistry, and are able to confine dyes and drug molecules efficiently.

Purpose: The aim of this study was to investigate the effect of lipid and polyethylene glycol (PEG) surface modifications on MSN stem-cell-tracking abilities. Read More

View Article
November 2018