4,061 results match your criteria Nanomedicine [Journal]


Natural and synthetic nanopores directing osteogenic differentiation of human stem cells.

Nanomedicine 2019 Feb 13. Epub 2019 Feb 13.

Department of Cell Biology, Bielefeld University, Universitätsstrasse 25, 33615 Bielefeld, Germany; Molecular Neurobiology, Bielefeld University, Universitätsstrasse 25, 33615 Bielefeld, Germany; Bielefeld Institute for Nanoscience (BINAS), Bielefeld University, Universitätsstrasse 25, 33615 Bielefeld, Germany. Electronic address:

Bone regeneration is a highly orchestrated process crucial for endogenous healing procedures after accidents, infections or tumor therapy. Changes in surface nanotopography are known to directly affect the formation of osteogenic cell types, although no direct linkage to the endogenous nanotopography of bone was described so far. Here we show the presence of pores of 31. Read More

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http://dx.doi.org/10.1016/j.nano.2019.01.018DOI Listing
February 2019

Electron microscopy in human diseases: diagnostic and research perspectives.

Nanomedicine (Lond) 2019 Feb 18;14(4):371-373. Epub 2019 Jan 18.

Department of Experimental Medicine & Surgery, University of Rome Tor Vergata, Via Montpellier 1, Rome 00133, Italy.

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http://dx.doi.org/10.2217/nnm-2018-0407DOI Listing
February 2019

Ultra-pH-sensitive indocyanine green-conjugated nanoprobes for fluorescence imaging-guided photothermal cancer therapy.

Nanomedicine 2019 Feb 11. Epub 2019 Feb 11.

State Key Laboratory of Natural and Biomimetic Drugs, School of Pharmaceutical Sciences, Peking University, Beijing 100191, China; Beijing Key Laboratory of Molecular Pharmaceutics, School of Pharmaceutical Sciences, Peking University, Beijing 100191, China. Electronic address:

Photothermal therapy (PTT) has been recognized as a promising approach for cancer treatment due to its minimal invasiveness and low systemic side effects. However, developing a photothermal agent with accurate tumor imaging capability is a prerequisite for the efficient PTT. Here, we developed a series of ultra-pH-sensitive indocyanine green (ICG)-conjugated nanoparticles for fluorescence imaging-guided tumor PTT. Read More

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http://dx.doi.org/10.1016/j.nano.2019.02.001DOI Listing
February 2019
2 Reads

Effects of titania nanotube surfaces on osteogenic differentiation of human adipose-derived stem cells.

Nanomedicine 2019 Feb 11. Epub 2019 Feb 11.

Department of Mechanical Engineering, Colorado State University, Fort Collins, CO, USA; School of Biomedical Engineering, Colorado State University, Fort Collins, CO, USA. Electronic address:

The surface of an implant is important for successful osseointegration and long-term stability as it can aid in cell migration and proliferation, cell differentiation and allow extracellular matrix production. Earlier studies have shown that nanostructuring the surface of titanium can enhance mesenchymal stem cell (MSC) migration, proliferation, and differentiation. Although many studies have evaluated MSC response on nanostructured surfaces, there are only a few studies that have explored the response of adipose-derived stem cells (ADSC) on titania nanotube surfaces. Read More

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http://dx.doi.org/10.1016/j.nano.2019.01.008DOI Listing
February 2019

HBO1 directs histone H4 specific acetylation, potentiating mechano-transductionpathways and membrane elasticity in ovarian cancer cells.

Nanomedicine 2019 Feb 10. Epub 2019 Feb 10.

Swansea University Medical School, Swansea, Wales, United Kingdom. Electronic address:

New approaches to treat ovarian cancer, the fifth leading cause of cancer death among women, are being sought, with the targeting of epigenetic modulators now receiving much attention. The histone acetyltransferase HBO1 functions in regulating diverse molecular processes, including DNA repair, transcription and replication, and is highly expressed in primary ovarian cancer. Here we define both the molecular function and a role in cell biomechanics for HBO1 in ovarian cancer. Read More

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http://dx.doi.org/10.1016/j.nano.2019.01.017DOI Listing
February 2019

The blood-brain barrier and beyond: Nano based neuropharmacology and the role of extracellular matrix.

Nanomedicine 2019 Feb 10. Epub 2019 Feb 10.

Center of Toxicology Science & Research, School of Medicine, University of Crete, Heraklion, Crete, Greece. Electronic address:

Restrained drug delivery due to the blood-brain barrier (BBB) considerably limits options for the treatment of brain pathologies. The utilization of nanoparticulate (NP) carriers has been proposed as a solution. The development strategies need to address the important hurdle of NP passage across the BBB as well as the altered cellular up-take due to the pathophysiological changes of the damaged or diseased tissue as well as immunological and toxicological aspects of nanomedicine penetration. Read More

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http://dx.doi.org/10.1016/j.nano.2019.01.016DOI Listing
February 2019

A novel nanoformulation of α-eleostearic acid restores molecular pathogenesis of hypersensitivity.

Nanomedicine (Lond) 2019 Feb 12. Epub 2019 Feb 12.

Laboratory of Food Science & Technology, Food & Nutrition Division, University of Calcutta, 20 B Judges Court Road, Kolkata 700 027, West Bengal, India.

Aim: The present work provides first-time empirical and molecular interaction evidence to establish the higher biofunctionality of a therapeutic lipid, α-eleostearic acid (ESA), encapsulated in a novel and thoroughly characterized biocompatible nanoemulsion (NE) system (particle size <200 nm).

Materials & Methods: A novel methodology was employed to fabricate novel formulations of ESA. Molecular biological tools and assays were used to arrive at definite conclusions. Read More

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http://dx.doi.org/10.2217/nnm-2018-0450DOI Listing
February 2019
2 Reads
5.413 Impact Factor

Freeze-dried and GMP-compliant pharmaceuticals containing exosomes for acellular mesenchymal stromal cell immunomodulant therapy.

Nanomedicine (Lond) 2019 Feb 11. Epub 2019 Feb 11.

Department of Drug Sciences, University of Pavia, Viale Taramelli 12, 27100 Pavia, Italy.

Aim: To validate the use of ultrafiltration (UF) as an alternative applicable industrial method to replace ultracentrifugation (UC) in the purification of mesenchymal stromal cell (MSC)-secretome.

Materials & Methods: Pharmaceutical formulations containing secretome and/or extracellular vesicles were extracted from adipose-MSCs and bone marrow-MSCs by combining UF or UC with lyophilization.

Results & Conclusion: UF led to higher protein, lipid, cytokine and exosomes yields compared with UC. Read More

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http://dx.doi.org/10.2217/nnm-2018-0240DOI Listing
February 2019

Effective encapsulation of apomorphine into biodegradable polymeric nanoparticles through a reversible chemical bond for delivery across the blood-brain barrier.

Nanomedicine 2019 Feb 6. Epub 2019 Feb 6.

Institute of Bioengineering and Nanotechnology, 31 Biopolis Way, Singapore 138669, Singapore. Electronic address:

Apomorphine (AMP, used for treatment of Parkinson's disease) is susceptible to oxidation. Its oxidized products are toxic. To overcome these issues, AMP was conjugated to phenylboronic acid-functionalized polycarbonate through pH-sensitive covalent boronate ester bond between phenylboronic acid and catechol in AMP. Read More

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http://dx.doi.org/10.1016/j.nano.2019.01.014DOI Listing
February 2019

Matryoshka-type gastro-resistant microparticles for the oral treatment of Mycobacterium tuberculosis.

Nanomedicine (Lond) 2019 Feb 8. Epub 2019 Feb 8.

Department of Chemical Engineering. Aragon Institute of Nanoscience (INA), University of Zaragoza, Campus Río Ebro-Edificio I+D, C/Poeta Mariano Esquillor S/N, Zaragoza 50018, Spain.

Aim: Production of Matryoshka-type gastroresistant microparticles containing antibiotic-loaded poly lactic-co-glycolic acid (PLGA) nanoparticles (NP) against Mycobacterium tuberculosis.

Materials & Methods: The emulsification and evaporation methods were followed for the synthesis of PLGA-NPs and methacrylic acid-ethyl acrylate-based coatings to protect rifampicin from degradation under simulated gastric conditions.

Results & Conclusion: The inner antibiotic-loaded NPs here reported can be released under simulated intestinal conditions whereas their coating protects them from degradation under simulated gastric conditions. Read More

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http://dx.doi.org/10.2217/nnm-2018-0258DOI Listing
February 2019
1 Read

Calcium carbonate nanoparticles stimulate tumor metabolic reprogramming and modulate tumor metastasis.

Nanomedicine (Lond) 2019 Jan 6;14(2):169-182. Epub 2018 Dec 6.

Mallinckrodt Institute of Radiology, Washington University in St Louis School of Medicine, St Louis, MO 63110, USA.

Aim: CaCO nanoparticles (nano-CaCO) can neutralize the acidic pHe of solid tumors, but the lack of intrinsic imaging signal precludes noninvasive monitoring of pH-perturbation in tumor microenvironment. We aim to develop a theranostic version of nano-CaCO to noninvasively monitor pH modulation and subsequent tumor response.

Materials & Methods: We synthesized ferromagnetic core coated with CaCO (magnetite CaCO). Read More

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http://dx.doi.org/10.2217/nnm-2018-0302DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6369564PMC
January 2019

Corrigendum to "Gold nanoparticle conjugated Rad6 inhibitor induces cell death in triple negative breast cancer cells by inducing mitochondrial dysfunction and PARP-1 hyperactivation: Synthesis and characterization" [Nanomedicine 12 (3) (2016), 745-757].

Nanomedicine 2019 Feb 3. Epub 2019 Feb 3.

Karmanos Cancer Institute, 110 E. Warren Avenue, Detroit, MI 48201; Department of Oncology, Wayne State University School of Medicine, 110 E. Warren Avenue, Detroit, MI 48201; Department of Pathology, Wayne State University School of Medicine, 110 E. Warren Avenue, Detroit, MI 48201. Electronic address:

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http://dx.doi.org/10.1016/j.nano.2019.01.005DOI Listing
February 2019
2 Reads

Nanoparticle-microRNA-146a-5p polyplexes ameliorate diabetic peripheral neuropathy by modulating inflammation and apoptosis.

Nanomedicine 2019 Feb 2. Epub 2019 Feb 2.

Department of Endocrinology, Jinshan Hospital, Fudan University, NO.1508, Longhang Road, Shanghai, 201508, China. Electronic address:

Nontoxic and nonimmunogenic nanoparticles play an increasingly important role in the application of pharmaceutical nanocarriers. The pathogenesis of diabetic peripheral neuropathy (DPN) has been extensively studied. However, the role of microRNAs in DPN remains to be clarified. Read More

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https://linkinghub.elsevier.com/retrieve/pii/S15499634193001
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http://dx.doi.org/10.1016/j.nano.2019.01.007DOI Listing
February 2019
3 Reads

Novel miRNA expression in the delta opioid signaling pathway mediated cell survivability in an in vitro model of ER stress.

Nanomedicine 2019 Feb 1. Epub 2019 Feb 1.

Cellular and Molecular Therapeutics Laboratory, Centre for Biomaterials, Cellular and Molecular Theranostics, Vellore Institute of Technology (VIT), Vellore, 632014, Tamil Nadu, India.. Electronic address:

Micro RNAs (miRNAs) are small non-coding RNAs which bind to the 3'-untranslated region of a mature mRNA to induce degradation; thereby regulating gene expression. It is reported that dysregulated miRNAs involved in neurodegenerative diseases including Parkinson's disease, could play a significant role as prognostic markers and therapeutic targets. Neuroprotective effect of delta opioid receptors (DOR) and its known miRNA regulation against endoplasmic reticulum (ER) stress have been reported previously by our lab. Read More

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http://dx.doi.org/10.1016/j.nano.2019.01.009DOI Listing
February 2019
6.155 Impact Factor

Greener synthesis of ZnO and Ag-ZnO nanoparticles using Silybum marianum for diverse biomedical applications.

Nanomedicine (Lond) 2019 Feb 4. Epub 2019 Feb 4.

Department of Eastern Medicine & Surgery, Qarshi University, Lahore, Pakistan.

Aim: To investigate the physical and biological properties of Silybum marianum inspired ZnO nanoparticles (NPs), Ag-ZnO heterostructures. Experiment: Nanoparticles were characterized using ultraviolet-visible and infrared spectroscopy, x-ray diffraction, high resolution electron microscopy, ζ potential and thermo-gravimetric analysis etc. Results: Ag-ZnO-NPs indicated slightly higher antimicrobial potential then ZnO-NPs. Read More

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http://dx.doi.org/10.2217/nnm-2018-0279DOI Listing
February 2019

Effects of topical methotrexate loaded gold nanoparticle in cutaneous inflammatory mouse model.

Nanomedicine 2019 Jan 29. Epub 2019 Jan 29.

Department of Dermatology, University of Modena and Reggio Emilia, Italy.

Gold nanoparticles functionalized with 3-mercapto-1-propansulfonate (AuNPs-3MPS) have been prepared and loaded with Methotrexate (MTX), an immunesuppressive agent used in the systemic treatment of moderate-severe inflammatory deseases. The effects of the AuNPs-3MPS@MTX topically administered in vitro on skin model and in vivo on imiquimod-induced psoriasis-like mice model, have been studied. Clinical response, epidermal thickness, cell proliferation rate and inflammation were tested. Read More

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http://dx.doi.org/10.1016/j.nano.2019.01.006DOI Listing
January 2019
1 Read

Zinc oxide nanoparticles attenuate hepatic steatosis development in high-fat-diet fed mice through activated AMPK signaling axis.

Nanomedicine 2019 Jan 29. Epub 2019 Jan 29.

School of Basic Sciences, Indian Institute of Technology Mandi, Mandi, -175001, H.P, India. Electronic address:

Insulin resistance is thought to be a common link between obesity and Non-Alcoholic Fatty Liver Disease (NAFLD). NAFLD has now reached epidemic status worldwide and identification of molecules or pathways as newer therapeutic strategies either to prevent or overcome insulin resistance seems critical. Dysregulated hepatic lipogenesis (DNL) is a hallmark of NAFLD in humans and rodents. Read More

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http://dx.doi.org/10.1016/j.nano.2019.01.013DOI Listing
January 2019
1 Read
6.155 Impact Factor

Poly(propylene imine) dendrimers with histidine-maltose shell as novel type of nanoparticles for synapse and memory protection.

Nanomedicine 2019 Jan 30. Epub 2019 Jan 30.

Institute of Neuropathology, IDIBELL-University Hospital Bellvitge, Feixa Llarga sn, 08907 L'Hospitalet de Llobregat, Spain; Wallenberg Neuroscience Center, Lund University, BMC B11, Sölvegatan 19, 22184 Lund, Sweden. Electronic address:

Poly(propylene imine) dendrimers have been shown to be promising 3-dimensional polymers for the use in the pharmaceutical and biomedical applications. Our aims of this study were first, to synthesize a novel type of dendrimer with poly(propylene imine) core and maltose-histidine shell (G4HisMal) assessing if maltose-histidine shell can improve the biocompatibility and the ability to cross the blood brain barrier, and second, to investigate the potential of G4HisMal to protect Alzheimer disease transgenic mice from memory impairment. Our data demonstrate that G4HisMal has significantly improved biocompatibility and ability to cross the blood brain barrier in vivo. Read More

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http://dx.doi.org/10.1016/j.nano.2019.01.010DOI Listing
January 2019

Raman spectral signatures of urinary extracellular vesicles from diabetic patients and hyperglycemic endothelial cells as potential biomarkers in diabetes.

Nanomedicine 2019 Jan 28. Epub 2019 Jan 28.

Department of Medical Physics, Marian Smoluchowski Institute of Physics Faculty of Physics, Astronomy and Applied Computer Science, Jagiellonian University, Krakow, Poland.

Raman spectroscopy was applied to the measurement of urinary and in vitro endothelium-derived extracellular vesicles (EVs) isolated by hydrostatic filtration dialysis (HFD) method. Raman spectra obtained for urinary EVs (UEVs) showed distinct differences in the fingerprint region. In contrast, average Raman spectra of endothelium-derived EVs samples were almost identical. Read More

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http://dx.doi.org/10.1016/j.nano.2019.01.011DOI Listing
January 2019
1 Read

Antibiofilm activity of natural zeolite supported NanoZnO: inhibition of Esp gene expression of Enterococcus faecalis.

Nanomedicine (Lond) 2019 Jan 31. Epub 2019 Jan 31.

Department of Pharmacology, School of Medicine, Tehran University of Medical Sciences, Tehran, Iran.

Aim: To evaluate the antibiofilm effect and esp gene downregulation of Enterococcus faecalis through nanozinc oxide fabricated on natural zeolite (NanoZnO/Ze). Materials & methods:Zeolite and NanoZnO/Ze materials were characterized by x-ray diffraction, x-ray fluorescence and field emission scanning electron microscopy coupled with energy dispersive x-ray. Atomic absorption spectroscopy was used to evaluate zinc release. Read More

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http://dx.doi.org/10.2217/nnm-2018-0173DOI Listing
January 2019
1 Read

Hemostatic and hepatoprotective bioactivity of Junci Medulla Carbonisata-derived Carbon Dots.

Nanomedicine (Lond) 2019 Feb 30;14(4):431-446. Epub 2019 Jan 30.

School of Traditional Chinese Medicine, Beijing University of Chinese Medicine, Beijing 100029, China.

Aim: To explore the hemostatic and hepatoprotective bioactivity of Junci Medulla Carbonisata-derived Carbon Dots (JMC-CDs).

Materials & Methods:  The JMC-CDs were characterized using transmission electron microscopy, HPLC, Fourier transform IR, UV, fluorescence and x-ray photoelectron spectroscopy. The hemostatic effect of JMC-CDs was evaluated and confirmed by trauma hemorrhagic animal models and internal hemorrhage animal model induced by Deinagkistrodon acutus venom. Read More

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https://www.futuremedicine.com/doi/10.2217/nnm-2018-0285
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http://dx.doi.org/10.2217/nnm-2018-0285DOI Listing
February 2019
6 Reads

Transfection of pulmonary cells by stable pDNA-polycationic hybrid nanostructured particles.

Nanomedicine (Lond) 2019 Feb 30;14(4):407-429. Epub 2019 Jan 30.

Research Institute for Medicines (iMed.ULisboa), Faculty of Pharmacy, Universidade de Lisboa, 1649-003 Lisbon, Portugal.

Aim: Cationically modified solid lipid nanoparticles (SLN) were investigated as plasmid DNA (pDNA) carriers and transfection agents for the pulmonary route.

Materials & Methods: pDNA-loaded SLN were produced using glyceryl dibehenate or tristearate as matrix lipids and chitosan as surface charge modifier, and encapsulated by spray-drying in mannitol and trehalose microspheres.

Results: Nanoparticles of 200 nm, and zeta potential around +15 mV were produced. Read More

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http://dx.doi.org/10.2217/nnm-2018-0270DOI Listing
February 2019

Attachment of flagellin enhances the immunostimulatory activity of a hemagglutinin-ferritin nano-cage.

Nanomedicine 2019 Jan 26. Epub 2019 Jan 26.

Department of Chemistry, Korea Advanced Institute of Science and Technology, Daejeon, Republic of Korea. Electronic address:

Hemagglutinin (HA) displayed on a ferritin nano-cage has been shown to be effective in generating a potent immune response against a broad range of influenza infections. Here, we showed that conjugation of flagellin together with HA to the exterior surface of the ferritin cage greatly enhanced not only the humoral immune response in mice but also antigen-specific T cell responses that include Th1 cytokine secretion. The effect of flagellin remained essentially unchanged when the molar ratio of flagellin to HA was reduced from 1:1 to 1:3. Read More

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http://dx.doi.org/10.1016/j.nano.2019.01.012DOI Listing
January 2019
1 Read

Solid lipid nanoparticles for ocular delivery of isoniazid: evaluation, proof of concept and in vivo safety & kinetics.

Nanomedicine (Lond) 2019 Feb 29;14(4):465-491. Epub 2019 Jan 29.

University Institute of Pharmaceutical Sciences, Panjab University, Chandigarh 160014, India.

Aim: Evaluation of solid lipid nanoparticles (SLNs) for ocular delivery of isoniazid (INH).

Materials & Methods: INH-SLNs were characterized for morphological, thermal, crystalline and nuclear magnetic resonance properties. In vitro release and ex vivo corneal permeability of INH-SLNs was also evaluated. Read More

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http://dx.doi.org/10.2217/nnm-2018-0278DOI Listing
February 2019
1 Read

Hyaluronic acid-modified cationic nanoparticles overcome enzyme CYP1B1-mediated breast cancer multidrug resistance.

Nanomedicine (Lond) 2019 Feb 29;14(4):447-464. Epub 2019 Jan 29.

School of Pharmacy, Shanghai Jiao Tong University, 800 Dongchuan Road, Shanghai 200240, China.

Aim: Enzyme CYP1B1 (CYP1B1) is usually overexpressed in multidrug resistance (MDR) breast cancer cells, which could metabolically inactivate docetaxel (DTX).

Materials & Methods: The cationic core-shell nanoparticles (hyaluronic acid/polyethyleneimine nanoparticles [HA/PEI NPs]) modified with hyaluronic acid (HA) were developed and coloaded with DTX and α-napthtoflavone (ANF, a CYP1B1 inhibitor) to overcome MDR in breast cancer induced by CYP1B1. Physicochemical characterization, MDR reversing effect in vitro and pharmacokinetics in vivo of HA/PEI NPs were evaluated. Read More

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http://dx.doi.org/10.2217/nnm-2018-0244DOI Listing
February 2019
5.413 Impact Factor

Autologous cancer cell-derived extracellular vesicles as drug-delivery systems: a systematic review of preclinical and clinical findings and translational implications.

Nanomedicine (Lond) 2019 Feb 29;14(4):493-509. Epub 2019 Jan 29.

Department of Pharmacy, The Second Xiangya Hospital, Central South University, Changsha 410011, Hunan, China.

Extracellular vesicles (EVs) are nanoscale natural membrane vesicles released by cells and are involved in intercellular communication. A number of studies have used autologous cancer cell-derived EVs (ACCD-EVs) as nanocarriers for delivery of therapeutics as they may be more efficiently uptaken by the cancer cells themselves. However, they also have been suggested to promote proliferation, survival and metastasis of cancers. Read More

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http://dx.doi.org/10.2217/nnm-2018-0286DOI Listing
February 2019

Pharmaceutical nanotechnology in Egypt: diverse applications and promising outcomes.

Authors:
Ahmed O Elzoghby

Nanomedicine (Lond) 2019 Jan 29. Epub 2019 Jan 29.

Cancer Nanotechnology Research Laboratory (CNRL), Faculty of Pharmacy, Alexandria University, Alexandria 21521, Egypt.

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https://www.futuremedicine.com/doi/10.2217/nnm-2018-0426
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http://dx.doi.org/10.2217/nnm-2018-0426DOI Listing
January 2019
3 Reads
5.413 Impact Factor

Biomolecular engineering of antidehydroepiandrosterone antibodies: a new perspective in cancer diagnosis and treatment using single-chain antibody variable fragment.

Nanomedicine (Lond) 2019 Jan 29. Epub 2019 Jan 29.

Pós-graduação em Engenharia de Bioprocessos e Biotecnologia, Curitiba, Brazil.

Aim: To develop a monoclonal antibody against dehydroepiandrosterone (DHEA) and miniaturize it, generating a single-chain antibody variable fragment (scFv) against DHEA as an adrenocortical carcinoma (ACC) marker.

Material & Methods: DHEA conjugated to keyhole limpet hemocyanin was used as an immunogen to obtain anti-DHEA hybridomas. Variable fragments were cloned from hybridoma 5B7 total RNA, and used to detect DHEA in normal adrenal tissue and ACC cells. Read More

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http://dx.doi.org/10.2217/nnm-2018-0230DOI Listing
January 2019
2 Reads

Mannosylated thiolated paromomycin-loaded PLGA nanoparticles for the oral therapy of visceral leishmaniasis.

Nanomedicine (Lond) 2019 Feb 28;14(4):387-406. Epub 2019 Jan 28.

Department of Pharmacy, Quaid-I-Azam University, Islamabad 44000, Pakistan.

Aim: The present study evaluates the efficacy of paromomycin (PM)-loaded mannosylated thiomeric nanoparticles for the targeted delivery to pathological organs for the oral therapy of visceral leishmaniasis.

Materials & Methods: Mannosylated thiolated chitosan (MTC)-coated PM-loaded PLGA nanoparticles (MTC-PLGA-PM) were synthesized and evaluated for morphology, drug release, permeation enhancing and antileishmanial potential.

Results: MTC-PLGA-PM were spherical in shape with a size of 391. Read More

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https://www.futuremedicine.com/doi/10.2217/nnm-2018-0038
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http://dx.doi.org/10.2217/nnm-2018-0038DOI Listing
February 2019
5 Reads

Comparative toxicity of PEG and folate-derived blue-emitting silicon nanoparticles: in vitro and in vivo studies.

Nanomedicine (Lond) 2019 Feb 28;14(4):375-385. Epub 2019 Jan 28.

Laboratorio de Biomembranas - GBEyB (IMBICE, CCT-La Plata, CONICET), Departamento de Ciencia y Tecnología, Universidad Nacional de Quilmes, 1876 Bernal, Argentina.

Aim: Amino functionalization is a first step modification aiming to achieve biomedical applications of silicon nanoparticles, for example, for photodynamic therapy or radiotherapy. Nevertheless, toxicity and low quantum yields due to the positive charge of amino groups emerge as a problem that could be solved with subsequent derivatizations.

Materials & Methods: Folic and PEG-conjugated nanoparticles were obtained from amino-functionalized silicon nanoparticle (NHSiNP). Read More

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http://dx.doi.org/10.2217/nnm-2018-0251DOI Listing
February 2019

Controlled release of dexamethasone sodium phosphate with biodegradable nanoparticles for preventing experimental corneal neovascularization.

Nanomedicine 2019 Jan 21;17:119-123. Epub 2019 Jan 21.

Department of Ophthalmology, The Johns Hopkins University School of Medicine, Baltimore, MD, USA; Center for Nanomedicine, Wilmer Eye Institute, The Johns Hopkins University School of Medicine, Baltimore, MD, USA; Department of Pharmaceutics Virginia Commonwealth University, Richmond, VA, USA; Department of Ophthalmology, and Massey Cancer Center, Virginia Commonwealth University, Richmond, VA, USA. Electronic address:

Corneal neovascularization (CNV) leads to the loss of corneal transparency and vision impairment, and can ultimately cause blindness. Topical corticosteroids are the first line treatment for suppressing CNV, but poor ocular bioavailability and rapid clearance of eye drops makes frequent administration necessary. Patient compliance with frequent eye drop application regimens is poor. Read More

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http://dx.doi.org/10.1016/j.nano.2019.01.001DOI Listing
January 2019
2 Reads
6.155 Impact Factor

Engineered Relaxin as theranostic nanomedicine to diagnose and ameliorate liver cirrhosis.

Nanomedicine 2019 Jan 22;17:106-118. Epub 2019 Jan 22.

Department of Biomaterials Science and Technology, Technical Medical Centre, Faculty of Science and Technology, University of Twente, Enschede, The Netherlands. Electronic address:

Hepatic cirrhosis is a growing health problem with increasing mortality worldwide. So far, there is a lack of early diagnosis and no clinical therapy is approved for the treatment. In this study, we developed a novel theranostic nanomedicine by targeting relaxin (RLX) that is known to possess potent anti-fibrotic properties but simultaneously has poor pharmacokinetics and detrimental off-target effects. Read More

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http://dx.doi.org/10.1016/j.nano.2018.12.008DOI Listing
January 2019
3 Reads

Poly(allylamine hydrochloride)-functionalized reduced graphene oxide for synergistic chemo-photothermal therapy.

Nanomedicine (Lond) 2019 Feb 24;14(3):255-274. Epub 2019 Jan 24.

School of Basic Sciences, Indian Institute of Technology Mandi, Kamand, Mandi-175005, Himachal Pradesh, India.

Aim: To develop near-infrared (NIR) light-responsive reduced graphene oxide (RGO)-based nanocomposites with improved stability, biocompatibility and enhanced in vitro chemo-photothermal therapeutic efficiency.

Materials & Methods: Poly(allylamine hydrochloride)-functionalized RGO-based nanocomposites (RGO-PAH) were synthesized and thoroughly characterized. In vitro biocompatibility, cellular uptake and in vitro synergistic chemo-photothermal therapeutic efficiency of drug-loaded RGO-PAH nanocomposites were evaluated along with elucidation of cell death mechanism. Read More

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http://dx.doi.org/10.2217/nnm-2018-0320DOI Listing
February 2019
4 Reads

Doxorubicin conjugated with nanodiamonds and in free form commit glioblastoma cells to heterodromous fates.

Nanomedicine (Lond) 2019 Feb 24;14(3):335-351. Epub 2019 Jan 24.

Department of Pharmacology, School of Basic Medicine, Wuhan University, Donghu Avenue No. 185, Wuhan 430072, China.

Aim: To mechanistically compare the effects of doxorubicin (DOX) and DOX conjugated with nanodiamonds (Nano-DOX) on human glioblastoma cells (GC).

Materials & Methods: GC viablity, proliferation and activation of apoptosis and autophagy was assayed in response to DOX and Nano-DOX. Expression and release of HMGB1 were measured and its role in apoptosis and autophagy probed in response to DOX and Nano-DOX. Read More

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https://www.futuremedicine.com/doi/10.2217/nnm-2018-0330
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http://dx.doi.org/10.2217/nnm-2018-0330DOI Listing
February 2019
5 Reads

Antibody-functionalized gold nanoparticles as tumor-targeting radiosensitizers for proton therapy.

Nanomedicine (Lond) 2019 Feb 24;14(3):317-333. Epub 2019 Jan 24.

Research Center for the Physics of Matter & Radiation (PMR-LARN), Namur Research Institute for Life Sciences (NARILIS), University of Namur, B-5000 Namur, Belgium.

Aim: This study aimed at developing antibody-functionalized gold nanoparticles (AuNPs) to selectively target cancer cells and probing their potential radiosensitizing effects under proton irradiation.

Materials & Methods: AuNPs were conjugated with cetuximab (Ctxb-AuNPs). Ctxb-AuNP uptake was evaluated by transmission electron microscopy and atomic absorption spectroscopy. Read More

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http://dx.doi.org/10.2217/nnm-2018-0161DOI Listing
February 2019
1 Read
5.413 Impact Factor

Core-sheath micro/nano fiber membrane with antibacterial and osteogenic dual functions as biomimetic artificial periosteum for bone regeneration applications.

Nanomedicine 2019 Jan 19. Epub 2019 Jan 19.

Beijing Laboratory of Biomedical Materials, Beijing University of Chemical Technology, Beijing, PR China; State Key Laboratory of Organic-Inorganic Composites, Beijing University of Chemical Technology, Beijing, PR China. Electronic address:

The traditional Chinese medicine icariin (ICA) and broad-spectrum antibacterial drug moxifloxacin hydrochloride (MOX) were introduced into a polycaprolactone core and gelatin shell, respectively, to develop osteogenic and antibacterial biomimetic periosteum by coaxial electrospinning. The physical properties, drug release, degradation, antibacterial property, in vitro and in vivo osteogenesis performances were investigated. Results demonstrated that stepwise and controlled drug release profiles were achieved based on the core-shell configuration and disparate degradation rate of PCL and gelatin. Read More

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http://dx.doi.org/10.1016/j.nano.2019.01.002DOI Listing
January 2019
3 Reads

Uptake and intracellular fate of biocompatible nanocarriers in cycling and noncycling cells.

Nanomedicine (Lond) 2019 Feb 22;14(3):301-316. Epub 2019 Jan 22.

Department of Neurosciences, Biomedicine & Movement Sciences, University of Verona, Strada Le Grazie, 8 - 37134 Verona, Italy.

Aim: To elucidate whether different cytokinetic features (i.e., presence or absence of mitotic activity) may influence cell uptake and distribution of nanocarriers, in vitro tests on liposomes, mesoporous silica nanoparticles, poly(lactide-co-glycolide) nanoparticles and nanohydrogels were carried out on C2C12 murine muscle cells either able to proliferate as myoblasts (cycling cells) or terminally differentiate into myotubes (noncycling cells). Read More

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http://dx.doi.org/10.2217/nnm-2018-0148DOI Listing
February 2019
2 Reads

MicroRNA signature changes during induction of neural stem cells from human mesenchymal stem cells.

Nanomedicine 2019 Jan 19;17:94-105. Epub 2019 Jan 19.

Cellular and Molecular Therapeutics Laboratory, Centre for Biomaterials, Cellular and Molecular Theranostics, Vellore Institute of Technology (VIT), Vellore, Tamilnadu, India. Electronic address:

MicroRNAs (miRNAs) are noncoding small RNA molecules that act as decisive roles in cell proliferation and differentiation processes by targeted inhibition of mature mRNA. In this study, miRNAs that are involved in the differentiation of neural stem cells (NSC) from human mesenchymal stem cells (MSC) were completely profiled and identified to elucidate the significant miRNAs responsible for NSC differentiation. Human MSCs were induced with NSC-differentiation cocktail containing epidermal growth factor and fibroblast growth factor under serum-free conditions. Read More

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http://dx.doi.org/10.1016/j.nano.2019.01.003DOI Listing
January 2019
2 Reads
6.155 Impact Factor

The clinical pharmacokinetics impact of medical nanometals on drug delivery system.

Authors:
Ahmed Alalaiwe

Nanomedicine 2019 Jan 19;17:47-61. Epub 2019 Jan 19.

Department of Pharmaceutics, College of Pharmacy, Prince Sattam Bin Abdulaziz University, Alkharj, KSA. Electronic address:

Nanometals are widely being used for diagnosis, treatment and monitoring of medical conditions. Majorly, nanometals are used to facilitate the delivery of drug to targeted site, minimize drug's penetration to healthy tissues, increase drug's bioavailability, and inhibit its uptake and elimination from the blood by reticuloendothelial process. Despite several benefits, use of nanoparticles as drug carriers is also associated with many problems including instability in blood during circulation, undesirable biodistribution, and toxicity. Read More

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http://dx.doi.org/10.1016/j.nano.2019.01.004DOI Listing
January 2019
3 Reads

Retinal bioavailability of liposomal minocycline after sub-conjunctival administration is low.

Authors:
Arto Urtti

Nanomedicine 2019 Jan 19. Epub 2019 Jan 19.

Laboratory of Biohybrid Technologies (Russian Mega-Grant 14.W03.031.0025), Institute of Chemistry, Saint-Petersburg State University, Russian Federation; Faculty of Pharmacy, University of Helsinki, Finland; School of Pharmacy, University of Eastern Finland, Kuopio, Finland. Electronic address:

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http://dx.doi.org/10.1016/j.nano.2018.12.012DOI Listing
January 2019
2 Reads

Zebrafish as a predictive screening model to assess macrophage clearance of liposomes in vivo.

Nanomedicine 2019 Jan 17;17:82-93. Epub 2019 Jan 17.

Division of Pharmaceutical Technology, Department of Pharmaceutical Sciences, University of Basel, Basel, Switzerland. Electronic address:

Macrophage recognition of nanoparticles is highly influenced by particle size and surface modification. Due to the lack of appropriate in vivo screening models, it is still challenging and time-consuming to characterize and optimize nanomedicines regarding this undesired clearance mechanism. Therefore, we validate zebrafish embryos as an emerging vertebrate screening tool to assess the macrophage sequestration of surface modified particulate formulations with varying particle size under realistic biological conditions. Read More

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http://dx.doi.org/10.1016/j.nano.2018.11.017DOI Listing
January 2019
2 Reads

Effects of silver nanoparticles functionalized with Cornus mas L. extract on architecture and apoptosis in rat testicle.

Nanomedicine (Lond) 2019 Feb 18;14(3):275-299. Epub 2019 Jan 18.

Department of Physiology, 'Iuliu Hatieganu' University of Medicine & Pharmacy, 1-3 Clinicilor Street, 400006, Cluj-Napoca, Romania.

Aim: To assess ultrastructural changes, alterations in matrix metalloproteinase activity and apoptosis induced by silver nanoparticles (AgNPs) in the rat testicle.

Materials & Methods: For 45 days, two groups of animals received different doses of AgNPs (0.8 and 1. Read More

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https://www.futuremedicine.com/doi/10.2217/nnm-2018-0193
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http://dx.doi.org/10.2217/nnm-2018-0193DOI Listing
February 2019
3 Reads

Size-dependent cellular uptake and TLR4 attenuation by gold nanoparticles in lung adenocarcinoma cells.

Nanomedicine (Lond) 2019 Feb 18;14(3):229-253. Epub 2019 Jan 18.

School of Bioscience, IIT Kharagpur, School of Bioscience, IIT, Kharagpur, India.

Aim: To elucidate uptake mechanisms and immunomodulatory potential of differently sized gold nanoparticles (GNPs) in lung adenocarcinoma cells (A549) to enable their use as an adjunct therapy for treating inflammation-linked lung cancer.

Methods: Internalization of the synthesized (5, 15 and 30 nm) GNPs by various endocytosis pathways was determined. Immunomodulatory mechanisms induced by differently sized GNPs in A549 cells in the presence of TLR4 and TLR9 ligands were evaluated. Read More

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https://www.futuremedicine.com/doi/10.2217/nnm-2018-0266
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http://dx.doi.org/10.2217/nnm-2018-0266DOI Listing
February 2019
4 Reads

Synergic antibacterial coatings combining titanium nanocolumns and tellurium nanorods.

Nanomedicine 2019 Jan 14;17:36-46. Epub 2019 Jan 14.

Chemical Engineering Department, Northeastern University, Boston, MA, USA; Instituto de Micro y Nanotecnología, IMN-CNM, CSIC (CEI UAM+CSIC), Tres Cantos, Spain. Electronic address:

Nanocolumnar titanium coatings have been fabricated in two sputtering systems with very different characteristics (a laboratory setup and semi-industrial equipment), thus possessing different morphologies (150 nm long columns tilted 20° from the normal and 300 nm long ones tilted 40°, respectively). These coatings exhibit similar antibacterial properties against Gram positive (Staphylococcus aureus) and Gram negative (Escherichia coli) bacteria. When a synergic route is followed and these coatings are functionalized with tellurium (Te) nanorods, the antibacterial properties are enhanced, especially for the long nanocolumns case. Read More

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http://dx.doi.org/10.1016/j.nano.2018.12.009DOI Listing
January 2019
3 Reads

A new immune-nanoplatform for promoting adaptive antitumor immune response.

Nanomedicine 2019 Jan 14;17:13-25. Epub 2019 Jan 14.

Department of Pharmacy and Pharmaceutical Technology, School of Pharmacy, University of Navarra, Pamplona, Spain; Navarra Institute for Health Research (IdisNA). Electronic address:

Immunoliposomes (ILs), obtained with monoclonal antibodies (mAbs) decorating the liposome surface, are used for cancer treatment. These mAbs provide the recognition of molecules upregulated in cancer cells, like Programmed Death-Ligand 1 (PD-L1), an immune-checkpoint involved in tumor resistance, forming a complex that blocks this molecule and thereby, induces antitumor immune response. This mechanism introduces a new concept for ILs. Read More

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https://linkinghub.elsevier.com/retrieve/pii/S15499634193000
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http://dx.doi.org/10.1016/j.nano.2018.12.016DOI Listing
January 2019
3 Reads

Unambiguous detection of atherosclerosis using bioorthogonal nanomaterials.

Nanomedicine 2019 Jan 14;17:26-35. Epub 2019 Jan 14.

Centro Nacional de Investigaciones Cardiovasculares Carlos III (CNIC) and CIBERES, Madrid. Spain; Instituto de Química Médica, Consejo Superior de Investigaciones Científicas (CSIC), Madrid, Spain. Electronic address:

The importance of atherosclerosis is driving research to create improved diagnostic tools based on molecular imaging. Pretargeted imaging is the use of bioorthogonal probes that selectively accumulate upon reaction with a pre-modified biomolecule in vivo. To date, this very promising approach has not been applied to atherosclerosis. Read More

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https://linkinghub.elsevier.com/retrieve/pii/S15499634193000
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http://dx.doi.org/10.1016/j.nano.2018.12.015DOI Listing
January 2019
5 Reads

PEGylated mesoporous BiS nanostars loaded with chlorin e6 and doxorubicin for fluorescence/CT imaging-guided multimodal therapy of cancer.

Nanomedicine 2019 Jan 14;17:1-12. Epub 2019 Jan 14.

Key Laboratory of Luminescent and Real-Time Analytical Chemistry (Southwest University), Ministry of Education, Faculty of Materials and Energy, Southwest University, Chongqing, China; Chongqing Engineering Research Center for Micro-Nano Biomedical Materials and Devices, Chongqing, China. Electronic address:

Taking advantage of the mesoporous structure of bismuth sulfide nanostars (BiS NSs), a chemotherapeutic drug of doxorubicin (DOX) and a photosensitizer of chlorin e6 (Ce6) were concurrently loaded in the PEGylated BiS NSs to formulate a multifunctional nanocomplex (BPDC NSs) for tumor theranostics. BPDC NSs have excellent photothermal conversion efficiency and a capacity of yielding reactive oxygen species (ROS) upon laser irradiation, and can realize on-demand drug release by either pH-activation or thermal induction. Accumulation of the nanodrug could be monitored in real-time by infrared thermal imaging, fluorescence imaging and computed tomography (CT). Read More

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http://dx.doi.org/10.1016/j.nano.2018.12.013DOI Listing
January 2019
2 Reads
6.155 Impact Factor

Endoscopic Cerenkov luminescence imaging and image-guided tumor resection on hepatocellular carcinoma-bearing mouse models.

Nanomedicine 2019 Jan 14;17:62-70. Epub 2019 Jan 14.

School of Life Science and Technology, Xidian University, Xi'an, Shaanxi, China; CAS Key Laboratory of Molecular Imaging, Beijing Key Laboratory of Molecular Imaging, The State Key Laboratory of Management and Control for Complex Systems, Institute of Automation, Chinese Academy of Sciences, Beijing, China; University of Chinese Academy of Sciences, Beijing, China. Electronic address:

Detecting deep tumors inside living subject is still challenging for Cerenkov luminescence imaging (CLI). In this study, a high-sensitivity endoscopic CLI (ECLI) system was developed with a dual-mode deep cooling approach to improve the imaging sensitivity. System was characterized through a series of ex vivo studies. Read More

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https://linkinghub.elsevier.com/retrieve/pii/S15499634193001
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http://dx.doi.org/10.1016/j.nano.2018.12.017DOI Listing
January 2019
8 Reads

Nanoliposome targeting in breast cancer is influenced by the tumor microenvironment.

Nanomedicine 2019 Jan 14;17:71-81. Epub 2019 Jan 14.

Merrimack Pharmaceuticals, Inc., Cambridge, MA, USA. Electronic address:

MM-302 is an anti-HER2 antibody-targeted pegylated liposomal doxorubicin designed to deliver doxorubicin specifically to HER2-expressing solid tumors. The delivery and activity of MM-302 were evaluated in orthotopic, transgenic, and intravenous breast cancer models expressing varying levels of HER2 that metastasize to some of the most common sites of dissemination for breast cancer, namely, lung, liver, and brain. Metastatic burden was quantified by gross evaluation, immunohistochemistry (IHC), and bioluminescent imaging. Read More

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http://dx.doi.org/10.1016/j.nano.2018.12.010DOI Listing
January 2019
2 Reads

Hybrid quantum dot-based theranostic nanomedicines for tumor-targeted drug delivery and cancer imaging.

Nanomedicine (Lond) 2019 Feb 17;14(3):225-228. Epub 2019 Jan 17.

Cancer Nanotechnology Research Laboratory (CNRL), Faculty of Pharmacy, Alexandria University, Alexandria 21521, Egypt.

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http://dx.doi.org/10.2217/nnm-2018-0414DOI Listing
February 2019
2 Reads
5.413 Impact Factor