4,126 results match your criteria Nanomedicine [Journal]


3D printed scaffolds with hierarchical biomimetic structure for osteochondral regeneration.

Nanomedicine 2019 Apr 17. Epub 2019 Apr 17.

Department of Mechanical and Aerospace Engineering, The George Washington University, Washington, DC 20052, USA; Department of Biomedical Engineering, The George Washington University, Washington, DC 20052, USA; Department of Electrical and Computer Engineering, The George Washington University, Washington, DC 20052, USA; Department of Medicine, The George Washington University, Washington, DC 20052, USA. Electronic address:

Osteochondral defects resulting from trauma and/or pathologic disorders are critical clinical problems. The current approaches still do not yield satisfactory due to insufficient donor sources and potential immunological rejection of implanted tissues. 3D printing technology has shown great promise for fabricating customizable, biomimetic tissue matrices. Read More

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https://linkinghub.elsevier.com/retrieve/pii/S15499634193008
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http://dx.doi.org/10.1016/j.nano.2019.04.002DOI Listing
April 2019
2 Reads

Tumor-targeted drug delivery and sensitization by MMP2-responsive polymeric micelles.

Nanomedicine 2019 Apr 17. Epub 2019 Apr 17.

Department of Pharmaceutical Sciences, Irma Lerma Rangel College of Pharmacy, Texas A&M University, College Station, TX 77843, United States. Electronic address:

Low tumor specificity and multidrug resistance (MDR) remain challenging for many anticancer drugs. In this study, the micelles assembled by a matrix metalloproteinase 2 (MMP2)-sensitive self-assembling efflux inhibitor (PEG2k-pp-PE) were developed and evaluated in various cancer models. In vitro, the PEG2k-pp-PE micelles enhanced the cellular uptake and tissue penetration and sensitized the cancers to drug treatments in MDR cancer cells and their three-dimensional multicellular spheroids. Read More

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http://dx.doi.org/10.1016/j.nano.2019.03.012DOI Listing

Nanoemulsion strategy of pioglitazone for the treatment of skin inflammatory diseases.

Nanomedicine 2019 Apr 17. Epub 2019 Apr 17.

Institute of Nanoscience and Nanotechnology (IN2UB), University of Barcelona, 08028 Barcelona, Spain; Department of Pharmacy and Pharmaceutical Technology, Faculty of Pharmacy, University of Granada, Granada, Spain. Electronic address:

Pioglitazone (PGZ) is a peroxisome proliferator-activated receptor agonist. Its role in the inflammatory response modulation opens the door for additional therapeutic applications. The purpose of this study was to develop a pioglitazone nanoemulsion (PGZ-NE) to investigate its anti-inflammatory efficacy on the skin. Read More

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https://linkinghub.elsevier.com/retrieve/pii/S15499634193007
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http://dx.doi.org/10.1016/j.nano.2019.03.017DOI Listing
April 2019
1 Read

Multilayer nanoscale functionalisation to treat disorders and enhance regeneration of bone tissue.

Nanomedicine 2019 Apr 16. Epub 2019 Apr 16.

School of Engineering, Newcastle University, Claremont Road, Newcastle upon Tyne NE1 7RU, United Kingdom. Electronic address:

The coatings application onto medical devices has experienced a continuous growth in the last few years. Medical device coating market is expected to grow at a CAGR of 5.16% to reach USD 10 million by 2023 due to the increasing geriatric population and the growing demand for continuous innovation. Read More

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http://dx.doi.org/10.1016/j.nano.2019.03.009DOI Listing

Rhamnolipid nanoparticles for in vivo drug delivery and photodynamic therapy.

Nanomedicine 2019 Apr 11. Epub 2019 Apr 11.

Department of Medical Life Sciences, College of Medicine, The Catholic University of Korea, 222 Banpo-daero, Seocho-gu, Seoul, 06591, Republic of Korea; Department of Biomedicine & Health Sciences, College of Medicine, The Catholic University of Korea, 222 Banpo-daero, Seocho-gu, Seoul, 06591, Republic of Korea; Catholic Photomedicine Research Institute, College of Medicine, The Catholic University of Korea, 222 Banpo-daero, Seocho-gu, Seoul, 06591, Republic of Korea. Electronic address:

Herein, we report the development of self-assembled nanoparticles using rhamnolipid, a biosurfactant. Rhamnolipid is produced by Pseudomonas aeruginosa, and has an amphiphilic structure that is suitable for the formation of a nanoparticle shell. These rhamnolipid nanoparticles were loaded with pheophorbide a (Pba), a hydrophobic photosensitizer. Read More

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https://linkinghub.elsevier.com/retrieve/pii/S15499634193007
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http://dx.doi.org/10.1016/j.nano.2019.03.015DOI Listing
April 2019
3 Reads

C FULLERENES SELECTIVELY INHIBIT BK BUT NOT K CHANNELS IN PULMONARY ARTERY SMOOTH MUSCLE CELLS.

Nanomedicine 2019 Apr 11. Epub 2019 Apr 11.

O.O. Bogomoletz Institute of Physiology, National Academy of Sciences of Ukraine, 4 Bogomoletz Str., 01024, Kyiv, Ukraine; ESC "Institute of Biology and Medicine", Taras Shevchenko National University of Kyiv, 64 Volodymyrska Str., 01601 Kyiv, Ukraine. Electronic address:

Possessing unique physical and chemical properties, C fullerenes are arising as a potential nanotechnological tool that can strongly affect various biological processes. Recent molecular modeling studies have shown that C fullerenes can interact with ion channels, but there is lack of data about possible effects of C molecule on ion channels expressed in smooth muscle cells (SMC). Here we show both computationally and experimentally that water-soluble pristine C fullerene strongly inhibits the large conductance Ca-dependent K (BK), but not voltage-gated K (K) channels in pulmonary artery SMC. Read More

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http://dx.doi.org/10.1016/j.nano.2019.03.018DOI Listing

Thrombolysis induced by intravenous Administration of Plasminogen Activator in Magnetoliposomes: Dual targeting by magnetic and thermal manipulation.

Nanomedicine 2019 Apr 11. Epub 2019 Apr 11.

Department of Physiology and Pharmacology, College of Medicine, Chang Gung University, Taoyuan, Taiwan, ROC; Department of Neurology, Chang Gung Memorial Hospital, Taoyuan, Taiwan, ROC. Electronic address:

In previously published studies, intra-arterial (i.a.), but not intravenous (i. Read More

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http://dx.doi.org/10.1016/j.nano.2019.03.014DOI Listing

Bronchial epithelial cell extracellular vesicles ameliorate epithelial-mesenchymal transition in COPD pathogenesis by alleviating M2 macrophage polarization.

Nanomedicine 2019 Apr 11. Epub 2019 Apr 11.

Department of Respiratory Medicine, The Third Xiangya Hospital of Central South University, Changsha, China. Electronic address:

Chronic obstructive pulmonary disease (COPD) is partly characterized as epithelial-mesenchymal transition (EMT)-related airflow limitation. Extracellular vesicles (EVs) play crucial roles in the crosstalk between cells, affecting many diseases including COPD. Up to now, the roles of EVs in COPD are still debated. Read More

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http://dx.doi.org/10.1016/j.nano.2019.03.010DOI Listing

Efficacy of two-weekly nanoparticle albumin-bound paclitaxel as neoadjuvant chemotherapy for breast cancer.

Nanomedicine (Lond) 2019 Apr 12. Epub 2019 Apr 12.

Breast Disease Department, the First Affiliated Hospital of Nanjing Medical University, Nanjing 210000, PR China.

Aim: Compare the two-weekly regimens of nanoparticle albumin-bound paclitaxel (nab-P) with solvent-based paclitaxel (sb-P) as neoadjuvant chemotherapy for breast cancer.

Materials & Methods: Patients (n = 162) with operable early breast cancer received four cycles of dose-dense epirubicin and cyclophosphamide followed by four two-weekly cycles of nab-P (n = 83) or sb-P (n = 79), with trastuzumab when needed.

Results: Across all the patients, the ypT0 ypN0 and ypT0/is ypN0 pathological complete response rates in the nab-P group were not superior to those in the sb-P group. Read More

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http://dx.doi.org/10.2217/nnm-2018-0485DOI Listing
April 2019
1 Read
5.413 Impact Factor

The phenotype of target pancreatic cancer cells influences cell death by magnetic hyperthermia with nanoparticles carrying gemicitabine and the pseudo-peptide NucAnt.

Nanomedicine 2019 Mar 30. Epub 2019 Mar 30.

Institute for Diagnostic and Interventional Radiology, Jena University Hospital-Friedrich Schiller University Jena, Jena, Germany. Electronic address:

In this paper we show that conjugation of magnetic nanoparticles (MNPs) with Gemcitabine and/or NucAnt (N6L) fostered their internalization into pancreatic tumor cells and that the coupling procedure did not alter the cytotoxic potential of the drugs. By treating tumor cells (BxPC3 and PANC-1) with the conjugated MNPs and magnetic hyperthermia (43 °C, 60 min), cell death was observed. The two pancreatic tumor cell lines showed different reactions against the combined therapy according to their intrinsic sensitivity against Gemcitabine (cell death, ROS production, ability to activate ERK 1/2 and JNK). Read More

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http://dx.doi.org/10.1016/j.nano.2018.12.019DOI Listing
March 2019
1 Read

Peptide-targeted liposomal delivery of dexamethasone for arthritis therapy.

Nanomedicine (Lond) 2019 Apr 2. Epub 2019 Apr 2.

Baltimore Veterans Affairs Medical Center, Baltimore, MD 21201, USA.

Aim: Rheumatoid arthritis is an autoimmune disease affecting the joints. Antiarthritic drugs are given systemically, thereby exposing various healthy organs to these drugs, resulting in adverse reactions. Accordingly, there is an urgent need for targeted drug delivery methods for inflamed joints. Read More

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http://dx.doi.org/10.2217/nnm-2018-0501DOI Listing
April 2019
3 Reads
5.413 Impact Factor

CRISPR-Cas14 is now part of the artillery for gene editing and molecular diagnostic.

Nanomedicine 2019 Mar 30. Epub 2019 Mar 30.

Laboratorio de Investigación en Genómica, Genética y Bioinformática. Torre de Hemato-Oncología, 4to Piso, Sección 2. Hospital Infantil de Mexico, Federico Gómez. Electronic address:

Recently Jennifer Doudna's group discovered the Clustered Regularly Interspaced Short Palindromic Repeats (CRISPR)-CRISPR associated protein 14 (Cas14), identified almost exclusively in a superphylum of extremophile archaea. The newly discovered Cas14 possesses a single-stranded (ss)DNA targeting activity - despite being two times smaller than Cas9 - a capability that might confer a defense against viruses with ssDNA genomes. Furthermore, by combining the non-specific ssDNase cleavage activity of Cas14 with isothermal amplification method (DETECTR-Cas14), it can also be promisingly exploited for high-fidelity DNA single-nucleotide polymorphism genotyping, and potentially for detecting ssDNA viruses of undeniable clinical, ecological, and economic importance infecting hosts in all three domains of life. Read More

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https://linkinghub.elsevier.com/retrieve/pii/S15499634193006
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http://dx.doi.org/10.1016/j.nano.2019.03.006DOI Listing
March 2019
4 Reads

Sirtuin 6 mediated stem cell cardiomyogenesis on protein coated nanofibrous scaffolds.

Nanomedicine 2019 Mar 26. Epub 2019 Mar 26.

Department of Materials Engineering, Indian Institute of Science, Bangalore, India; Centre for Biosystems Science and Engineering, Indian Institute of Science, Bangalore, India. Electronic address:

The cellular niche provides combination of biomolecular and biophysical cues to control stem cell fate. Three-dimensional (3D) aligned nanofibrous scaffolds can effectively augment stem cell cardiomyogenesis. This work aims to understand the role of biomolecular signals from extracellular matrix (ECM) proteins and leverage them to further promote cardiomyogenesis on nanofibrous scaffolds. Read More

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http://dx.doi.org/10.1016/j.nano.2019.03.005DOI Listing

Mitochondria and nucleus delivery of active form of 10-hydroxycamptothecin with dual shell to precisely treat colorectal cancer.

Nanomedicine (Lond) 2019 Apr 29;14(8):1011-1032. Epub 2019 Mar 29.

Department of Pharmaceutics, School of Pharmacy, Fourth Military Medical University, Xi'an 710032, PR China.

Aim: The objective of this study was to deliver a ring-closed form of 10-hydroxycamptothecin (HCPT) to the mitochondria and nucleus to treat colorectal cancer.

Materials & Methods: HCPT-loaded nanoparticle HCPT@PLGA-PEG-triphenylphosphonium/PLGA-hyd-PEG-folic acid (PT/PHF) and HCPT@PT/PLGA-SS-PEG-folic acid (PSF) were prepared by using emulsion-solvent evaporation method.

Results: In vitro experimental results indicated HCPT@PT/PHF and HCPT@PT/PSF maintained a large amount of HCPT in active form, and delivered more HCPT to the nucleus and mitochondria of the tumor cell, which resulted in the enhancement of cytotoxicity of HCPT. Read More

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http://dx.doi.org/10.2217/nnm-2018-0227DOI Listing

What potential do magnetic iron oxide nanoparticles have for the treatment of rheumatoid arthritis?

Authors:
Lin Wu Song Shen

Nanomedicine (Lond) 2019 Apr 29;14(8):927-930. Epub 2019 Mar 29.

Department of Pharmaceutics, School of Pharmaceutical Science, Jiangsu University, Zhenjiang 212013, China.

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http://dx.doi.org/10.2217/nnm-2019-0071DOI Listing
April 2019
1 Read

Liquid crystalline nanoreservoir releasing a highly skin-penetrating berberine oleate complex for psoriasis management.

Nanomedicine (Lond) 2019 Apr 29;14(8):931-954. Epub 2019 Mar 29.

Department of Pharmaceutics, Faculty of Pharmacy, Alexandria University, Egypt.

Aim: The current work highlighted preparation of highly penetrating liquid crystalline nanoparticulates (LCNPs) reservoir of a solubility modified berberine oleate (Brb-OL) complex for effective psoriasis management. Materials & methods: Brb-OL-loaded LCNPs (Brb-OL-LCNPs) were prepared using hydrotrope method.

Results: The proposed Brb-OL-LCNPs showed a particle size of 137 ± 3. Read More

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http://dx.doi.org/10.2217/nnm-2018-0345DOI Listing
April 2019
3 Reads

Development of near-infrared region luminescent N-acetyl-L-cysteine-coated AgS quantum dots with differential therapeutic effect.

Nanomedicine (Lond) 2019 Apr 27;14(8):969-987. Epub 2019 Mar 27.

Department of Chemistry, Koc University, Istanbul 34450, Turkey.

Aim: N-acetyl-L-cysteine (NAC) is a free radical scavenger. We developed NAC-coated AgS (NAC-AgS) quantum dot (QD) as an optical imaging and therapeutic agent.

Materials & Methods: QDs were synthesized in water. Read More

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http://dx.doi.org/10.2217/nnm-2018-0214DOI Listing
April 2019
1 Read

Pharmaceutical feasibility and flow characteristics of polymeric non-spherical particles.

Nanomedicine 2019 Mar 21;18:243-258. Epub 2019 Mar 21.

Department of Pharmaceutics and Drug Discovery, University of the Sciences in Philadelphia,Philadelphia, PA, USA.

Last decade has seen emergence of particle shape as a critical design parameter to overcome several long standing problems associated with particulate drug delivery- non-specific drug effects, RES uptake, poor bioavailability, achieving controlled release profiles, predictable degradation profiles, longer circulation time and zero order release kinetics to name a few. Non-spherical particles have been synthesized by techniques ranging from classical solvent evaporation to specialized techniques like film stretching and PRINT®. Non-spherical particles tend to show a difference in macrophage uptake, adhesion to target cells and distribution in vivo. Read More

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http://dx.doi.org/10.1016/j.nano.2019.03.002DOI Listing

Nano-based approach to combat emerging viral (NIPAH virus) infection.

Nanomedicine 2019 Mar 21;18:196-220. Epub 2019 Mar 21.

Post Graduate Department of Biotechnology, Utkal University, Vani Vihar, Bhubaneswar, Odisha, India. Electronic address:

Emergence of new virus and their heterogeneity are growing at an alarming rate. Sudden outburst of Nipah virus (NiV) has raised serious question about their instant management using conventional medication and diagnostic measures. A coherent strategy with versatility and comprehensive perspective to confront the rising distress could perhaps be effectuated by implementation of nanotechnology. Read More

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http://dx.doi.org/10.1016/j.nano.2019.03.004DOI Listing

Nanobiotechnology as an emerging approach to combat malaria: A systematic review.

Nanomedicine 2019 Mar 21;18:221-233. Epub 2019 Mar 21.

Infectious and Tropical Disease Research Center, Tabriz University of Medical Sciences, Tabriz, Iran; Drug Applied Research Center, Tabriz University of Medical Sciences, Tabriz, Iran. Electronic address:

Mosquitoes (Diptera; Culicidae) present a major threat to millions of people and animals worldwide, as they act as vectors for various pathogens, especially parasites and viruses. Resistance to insecticides, such as organophosphates and microbial control agents, and insufficient adherence to application guidelines are common reasons for insecticide treatment failure. Therefore, there is an urgent need for exploration of safer, cheaper, and more effective agents, with novel modes of action, to improve mosquito control. Read More

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https://linkinghub.elsevier.com/retrieve/pii/S15499634193004
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http://dx.doi.org/10.1016/j.nano.2019.02.017DOI Listing
March 2019
3 Reads

Inactivation of common hospital acquired pathogens on surfaces and in air utilizing engineered water nanostructures (EWNS) based nano-sanitizers.

Nanomedicine 2019 Mar 20;18:234-242. Epub 2019 Mar 20.

Center for Nanotechnology and Nanotoxicology, Department of Environmental Health, Harvard, T. H. Chan School of Public Health, Harvard University, Boston, MA, USA. Electronic address:

Infectious diseases represent a major public health challenge worldwide. There are various modes for the transmission of these diseases, with surface and airborne transmission being two of the most important ones. The inefficiencies of current intervention methods have resulted in the emergence of nosocomial infections. Read More

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https://linkinghub.elsevier.com/retrieve/pii/S15499634193006
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http://dx.doi.org/10.1016/j.nano.2019.03.003DOI Listing
March 2019
10 Reads
6.155 Impact Factor

Utility of nanomedicine targeting scar-forming myofibroblasts to attenuate corneal scarring and haze.

Nanomedicine (Lond) 2019 Apr 22;14(8):1049-1072. Epub 2019 Mar 22.

Nanomedicine-Laboratory of Immunology & Molecular Biomedical Research (NLIMBR), School of Medicine (SOM), Faculty of Health, Deakin University, Waurn Ponds, Geelong 3216, Australia.

Corneal scarring refers to the loss of normal corneal tissue, replaced by fibrotic tissue (during wound repair) thereby affecting corneal transparency and vision quality. The corneal wound healing process involves a complex series of physiological events resulting in the transformation of transparent keratocytes into opaque myofibroblasts; the prominent cause of irregular extracellular matrix synthesis leading to the development of corneal opacity/hazy vision. Globally, corneal scarring/haze is one of the most prevalent causes of blindness. Read More

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http://dx.doi.org/10.2217/nnm-2017-0305DOI Listing

Delivering DNA origami to cells.

Nanomedicine (Lond) 2019 04 22;14(7):911-925. Epub 2019 Mar 22.

Bionanoscience & Biochemistry Laboratory, Malopolska Centre of Biotechnology, Jagiellonian University, Gronostajowa 7A, 30-387 Krakow, Poland.

DNA nanotechnology research has long-held promise as a means of developing functional molecules capable of delivery to cells. Recent advances in DNA origami have begun to realize this potential but is still at the earliest stage and a number of hurdles remain. This review focuses on progress in addressing these hurdles and considers some of the challenges still outstanding. Read More

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http://dx.doi.org/10.2217/nnm-2018-0440DOI Listing
April 2019
3 Reads

Silencing PD-1 and PD-L1 with nanoparticle-delivered small interfering RNA increases cytotoxicity of tumor-infiltrating lymphocytes.

Nanomedicine (Lond) 2019 Apr 22;14(8):955-967. Epub 2019 Mar 22.

Australian Institute for Bioengineering & Nanotechnology, University of Queensland, St Lucia, QLD 4072, Australia.

Aim: To determine if silencing PD-1 on tumor-infiltrating lymphocytes (TILs) and its ligand-1 (PD-L1) on cancer cells will enhance the cytotoxicity of TILs.

Materials & Methods: Lipid-coated calcium phosphate nanoparticles were synthesized to deliver siRNAs against PD-1 and PD-L1 to TILs and breast cancer MCF-7 cells. The downregulation of PD-1/PD-L1 expressions was determined by real-time PCR and western blotting assays. Read More

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http://dx.doi.org/10.2217/nnm-2018-0237DOI Listing
April 2019
1 Read

Gold nanoparticles for sustained antileukemia drug release: development, optimization and evaluation by quality-by-design approach.

Nanomedicine (Lond) 2019 Apr 22;14(7):851-870. Epub 2019 Mar 22.

Department of Pharmaceutical Engineering & Technology, Indian Institute of Technology (Banaras Hindu University), Varanasi, India.

Aim: To design, develop, optimize and evaluate sustained-release dasatinib-loaded gold nanoparticles (DSB-GNPs) to treat chronic myeloid leukemia (CML) by using quality by design.

Materials & Methods: In this study, we performed risk assessment, optimization, in vitro characterizations, stability study, drug release studies, cytotoxicity study and in vivo pharmacokinetic evaluation.

Results: DSB-GNPs of desired size, entrapment, smooth, spherical, stable and sustained drug release for 48 h were achieved. Read More

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http://dx.doi.org/10.2217/nnm-2018-0306DOI Listing
April 2019
1 Read

Improving dispersal of therapeutic nanoparticles in the human body.

Nanomedicine (Lond) 2019 04 21;14(7):797-801. Epub 2019 Mar 21.

Department of Applied Science & Technology, Politecnico di Torino, Corso Duca degli Abruzzi 24, Torino 10129, Italy.

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http://dx.doi.org/10.2217/nnm-2019-0070DOI Listing
April 2019
5.413 Impact Factor

Liposome-encapsulated fish oil protein-tagged gold nanoparticles for intra-articular therapy in osteoarthritis.

Nanomedicine (Lond) 2019 Apr 21;14(7):871-887. Epub 2019 Mar 21.

Department of Biosciences & Bioengineering, Indian Institute of Technology Bombay, Powai, Mumbai, Maharashtra, 400076, India.

Aim: To provide multilayered combination therapies encompassing nanoparticles and organic peptides and to assess their efficacy in the treatment of arthritis.

Materials & Methods: Fish oil protein (FP) was isolated from fish oil glands and tagged with spherical gold nanoparticles (GNPs). Tagged GNPs were encapsulated in DPPC liposomes (FP-GNP-DPPC) and characterized. Read More

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http://dx.doi.org/10.2217/nnm-2018-0221DOI Listing
April 2019
2 Reads

NanoBioAnalytical characterization of extracellular vesicles in 75-nm nanofiltered human plasma for transfusion: A tool to improve transfusion safety.

Nanomedicine 2019 Mar 13. Epub 2019 Mar 13.

FEMTO-ST Institute, UBFC, CNRS, ENSMM, UTBM, 15B Avenue des Montboucons, 25030, Besançon, France. Electronic address:

Plasma transfusion induces some transfusion related acute lung injury (TRALI) mediated through neutrophil extracellular traps (NETs). We investigated whether extracellular vesicles (EVs) present in plasma or obtained from resting (N-PEVs) or thrombin activated platelets (T-PEVs) can trigger NETs, and whether 75nm-nanofiltration, to partially remove EVs, prohibits NETs formation. EVs size and concentration were determined by conventional biophysical approaches and by an original NanoBioAnalytical (NBA) platform based on EV immunocapture biochip, combining Surface Plasmon Resonance Imaging (SPRi) and Atomic Force Microscopy (AFM) exploration. Read More

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http://dx.doi.org/10.1016/j.nano.2019.02.026DOI Listing

Exploration of TiO nanoparticle mediated microdynamic therapy on cancer treatment.

Nanomedicine 2019 Mar 14. Epub 2019 Mar 14.

Department of Orthopedics, Guangdong Provincial People's Hospital, Guangdong Academy of Medical Sciences, Guangzhou, China. Electronic address:

Radical therapy takes advantage of the reactive oxygen species produced in greater quantities within tumor cells than in normal cells. Here, for the first time, we explore a TiO nanoparticle mediated microwave induced radical therapy (termed as Microdynamic Therapy) as a new cancer treatment method. The experiments in vitro and in vivo demonstrate that colloidal TiO nanoparticles could significantly suppress the growth of osteosarcomas, even under low power (5 W) microwave (MW) irradiation for 5 min. Read More

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http://dx.doi.org/10.1016/j.nano.2019.02.016DOI Listing
March 2019
5 Reads

Liposomes produced by microfluidics and extrusion: A comparison for scale-up purposes.

Nanomedicine 2019 Mar 13;18:146-156. Epub 2019 Mar 13.

Department of Pharmaceutical Sciences, College of Pharmacy, Oregon State University/OHSU, Portland, OR, USA. Electronic address:

Successful liposomal formulations in the clinic are severely limited due to poor translational capability of the traditional bench techniques to clinical production settings. The gold standard for liposome bench manufacturing is a multi-step and parameter dependent extrusion method. Moreover, these parameters need re-optimization for clinical production. Read More

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http://dx.doi.org/10.1016/j.nano.2019.02.019DOI Listing

Copper complex nanoformulations featuring highly promising therapeutic potential in murine melanoma models.

Nanomedicine (Lond) 2019 Apr 15;14(7):835-850. Epub 2019 Mar 15.

Research Institute for Medicines (iMed.ULisboa), Faculty of Pharmacy, Universidade de Lisboa, Av. Prof. Gama Pinto, 1649-003 Lisboa, Portugal.

Aim: Preclinical evaluation of a cytotoxic copper (II) complex formulated in long circulating nanoliposomes for melanoma treatment.

Materials & Methods: Liposomal nanoformulations of the copper complex were characterized in terms of thermodynamic behavior (differential scanning calorimeter), pH-sensitivity (spectrophotometry) and antiproliferative effects against murine melanoma B16F10 cells in vitro. Preclinical studies were performed in a C57BL/6 syngeneic melanoma model. Read More

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http://dx.doi.org/10.2217/nnm-2018-0388DOI Listing

Development of chlorin e6-conjugated poly(ethylene glycol)-poly(d,l-lactide) nanoparticles for photodynamic therapy.

Nanomedicine (Lond) 2019 Apr 15;14(7):819-834. Epub 2019 Mar 15.

Department of Pharmacy, Birla Institute of Technology & Science-Pilani, Hyderabad Campus, Jawahar Nagar, Medchal, Hyderabad 500078, Telangana, India.

Aim: In this study, we developed a chlorin e6-conjugated methoxy-poly(ethylene glycol)-poly(d,l-lactide) (mPEG-PLA-Ce6) amphiphilic polymer, which self-assembled to form stable nanoparticles.

Materials & Methods: The nanoparticles were characterized for particle size, ζ-potential and singlet oxygen (O) generation. Cellular internalization and phototoxicity were investigated against monolayer and 3D spheroids of human lung adenocarcinoma cells (A549). Read More

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http://dx.doi.org/10.2217/nnm-2018-0255DOI Listing
April 2019
5.413 Impact Factor

Asenapine maleate-loaded nanostructured lipid carriers: optimization and in vitro, ex vivo and in vivo evaluations.

Nanomedicine (Lond) 2019 Apr 15;14(7):889-910. Epub 2019 Mar 15.

Department of Pharmaceutics, Manipal College of Pharmaceutical Sciences, Manipal Academy of Higher Education, Manipal 576104, Karnataka State, India.

Aim: To prepare nanostructured lipid carriers (NLCs) loaded with asenapine maleate (ASPM) to increase its oral bioavailability by intestinal lymphatic uptake.

Materials & Methods: ASPM-NLCs were prepared by ultrasound dispersion technique, by adopting Design of Experiment approach, and characterized.

Results: The optimized formulation exhibited good physicochemical parameters. Read More

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http://dx.doi.org/10.2217/nnm-2018-0289DOI Listing
April 2019
5.413 Impact Factor

Pea-like nanocabins enable autonomous cruise and step-by-step drug pushing for deep tumor inhibition.

Nanomedicine 2019 Mar 8;18:122-134. Epub 2019 Mar 8.

Key Laboratory of Modern Chinese Medicines, China Pharmaceutical University, Nanjing, PR China. Electronic address:

Pea-like nanocabins (HA@APT§DOX) were designed for deep tumor inhibition. The AS1411 aptamer (APT) constituted "core shelf" which guaranteed DOX "beans" could be embedded, while the outer HA acted as "pea shell" coating. During the circulation (primary orbit), HA@APT§DOX could autonomously cruise until leak through tumor vasculature. Read More

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http://dx.doi.org/10.1016/j.nano.2019.02.025DOI Listing

Phase I/II trial of nano-camptothecin CRLX101 with capecitabine and radiotherapy as neoadjuvant treatment for locally advanced rectal cancer.

Nanomedicine 2019 Mar 8;18:189-195. Epub 2019 Mar 8.

Lineberger Comprehensive Cancer Center, University of North Carolina, Chapel Hill, NC; Department of Radiation Oncology, University of North Carolina, Chapel Hill, NC; Laboratory of Nano- and Translational Medicine, Carolina Center for Cancer Nanotechnology Excellent, Carolina Institute of Nanomedicine, University of North Carolina, Chapel Hill, NC. Electronic address:

CRLX101 is a nanoparticle-drug conjugate with a camptothecin payload. We assessed the toxicity and pathologic complete response (pCR) rate of CRLX101 with standard neoadjuvant chemoradiotherapy (CRT) in locally advanced rectal cancer. A single-arm study was conducted with a 3 + 3 dose escalation phase Ib followed by phase II at the maximum tolerated dose (MTD). Read More

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https://linkinghub.elsevier.com/retrieve/pii/S15499634193005
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http://dx.doi.org/10.1016/j.nano.2019.02.021DOI Listing
March 2019
6 Reads

Foxp3 plasmid-encapsulated PLGA nanoparticles attenuate pain behavior in rats with spinal nerve ligation.

Nanomedicine 2019 Mar 8;18:90-100. Epub 2019 Mar 8.

Department of Anatomy, Brain Research Institute, Chungnam National University School of Medicine, Daejeon, Republic of Korea. Electronic address:

Microglia play a critical role in neuropathic pain. Since upregulated Foxp3 in microglia enhances tissue repair by resolving neuroinflammation in excitotoxin-induced neuronal death, it may attenuate neuropathic pain in a similar manner. Therefore, this study tests whether Foxp3 introduced with poly (D, L-lactic-co-glycolic acid) (PLGA) nanoparticles (Foxp3 NPs) can alleviate neuropathic pain by inhibiting microglia activity. Read More

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http://dx.doi.org/10.1016/j.nano.2019.02.023DOI Listing

Magnetic 3D scaffold: A theranostic tool for tissue regeneration and non-invasive imaging in vivo.

Nanomedicine 2019 Mar 8;18:179-188. Epub 2019 Mar 8.

Centre for Nanosciences and Molecular Medicine, Amrita Institute of Medical sciences and Research Centre, Amrita Vishwa Vidyapeetham, Kochi, Kerala, India. Electronic address:

We report an osteoconducting magnetic 3D scaffold using Fe doped nano-hydroxyapatite-Alginate-Gelatin (AGHFe1) for Magnetic Resonance Imaging based non-invasive monitoring of bone tissue regeneration. In rat cranial defect model, the scaffold facilitated non-invasive monitoring of cell migration, inflammatory response and matrix deposition by unique changes in transverse relaxation time (T2). Cell infiltration resulted in a considerable increase in T2 from ~37 to ~62 ms, which gradually returned to that of native bone (~23 ms) by 90 days. Read More

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http://dx.doi.org/10.1016/j.nano.2019.02.022DOI Listing
March 2019
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Surface protein engineering increases the circulation time of a cell membrane-based nanotherapeutic.

Nanomedicine 2019 Mar 8;18:169-178. Epub 2019 Mar 8.

Cardiovascular Research Institute, National University Health System, Singapore; Department of Medicine, Yong Loo Lin School of Medicine, National University of Singapore, Singapore; Translational Laboratory in Genetic Medicine, Agency for Science, Technology and Research, Singapore; Department of Surgery, Yong Loo Lin School of Medicine, National University of Singapore, Singapore; Department of Biochemistry, Yong Loo Lin School of Medicine, National University of Singapore, Singapore. Electronic address:

Mammalian cell membranes are often incompatible with chemical modifications typically used to increase circulation half-life. Using cellular nanoghosts as a model, we show that proline-alanine-serine (PAS) peptide sequences expressed on the membrane surface can extend the circulation time of a cell membrane derived nanotherapeutic. Membrane expression of a PAS 40 repeat sequence decreased protein binding and resulted in a 90% decrease in macrophage uptake when compared with non-PASylated controls (P ≤ 0. Read More

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http://dx.doi.org/10.1016/j.nano.2019.02.024DOI Listing

Yttrium oxide nanoparticles reduce the severity of acute pancreatitis caused by cerulein hyperstimulation.

Nanomedicine 2019 Mar 6;18:54-65. Epub 2019 Mar 6.

Department of Regulatory Toxicology, National Institute of Pharmaceutical Education and Research (NIPER), Balanagar, Hyderabad, Telangana, India. Electronic address:

Oxidative stress plays a major role in acute pancreatitis (AP), leading to massive macrophage infiltration. Nanoyttria (NY) possesses potent free radical scavenging activity. As reactive oxygen species and inflammation play major role in AP, we hypothesized that NY may alleviate cerulein induced AP. Read More

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http://dx.doi.org/10.1016/j.nano.2019.02.018DOI Listing

Safety and effectiveness of sodium colistimethate-loaded nanostructured lipid carriers (SCM-NLC) against P. aeruginosa: in vitro and in vivo studies following pulmonary and intramuscular administration.

Nanomedicine 2019 Mar 6;18:101-111. Epub 2019 Mar 6.

NanoBioCel Group, Laboratory of Pharmaceutics, University of the Basque Country (UPV/EHU), School of Pharmacy, Vitoria-Gasteiz, Spain; Biomedical Research Networking Center in Bioengineering, Biomaterials and Nanomedicine (CIBER-BBN), Vitoria-Gasteiz, Spain. Electronic address:

The usefulness of nanotechnology to increase the bioavailability of drugs and decrease their toxicity may be a tool to deal with multiresistant P. aeruginosa (Mr-Pa) respiratory infections. We describe the preparation and the in vivo efficacy and safety of sodium colistimethate-loaded nanostructured lipid carriers (SCM-NLC) by the pulmonary and intramuscular routes. Read More

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http://dx.doi.org/10.1016/j.nano.2019.02.014DOI Listing
March 2019
1 Read

Integrin-targeted AmpRGD sunitinib liposomes as integrated antiangiogenic tools.

Nanomedicine 2019 Mar 6;18:135-145. Epub 2019 Mar 6.

Dipartimento di Scienze degli Alimenti e del Farmaco, Università di Parma, Parma, Italy. Electronic address:

We report here the preparation, physico-chemical characterization, and biological evaluation of a new liposome formulation as a tool for tumor angiogenesis inhibition. Liposomes are loaded with sunitinib, a tyrosine kinase inhibitor, and decorated with cyclo-aminoprolineRGD units (cAmpRGD), efficient and selective ligands for integrin αβ. The RGD units play multiple roles since they target the nanovehicles at the integrin αβ-overexpressing cells (e. Read More

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http://dx.doi.org/10.1016/j.nano.2019.02.015DOI Listing
March 2019
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Tumor selective uptake of drug-nanodiamond complexes improves therapeutic outcome in pancreatic cancer.

Nanomedicine 2019 Mar 6;18:112-121. Epub 2019 Mar 6.

Division of Molecular Toxicology, Institute of Environmental Medicine, Karolinska Institutet, Stockholm, Sweden. Electronic address:

Pancreatic ductal adenocarcinoma (PDAC) is one of the leading causes of cancer-related deaths and novel treatment approaches are urgently needed. Here we show that poly(ethylene glycol)-functionalized nanodiamonds loaded with doxorubicin (ND-PEG-DOX) afforded a considerable improvement over free drug in an orthotopic pancreatic xenograft model. ND-PEG-DOX complexes were also superior to free DOX in 3-dimensional (3D) tumor spheroids of PDAC. Read More

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http://dx.doi.org/10.1016/j.nano.2019.02.020DOI Listing
March 2019
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Europium labeled lactosylated albumin as a model workflow for the development of biotherapeutics.

Nanomedicine 2019 Mar 4;18:21-30. Epub 2019 Mar 4.

Chemical and Biological Technologies for Health (UTCBS), CNRS UMR8258, INSERM U1022, Paris Descartes University, Sorbonne-Paris-Cité, Chimie ParisTech, PSL Research University, School of Pharmacy, Paris, France. Electronic address:

Lactosylated albumin is currently used as a radiopharmaceutical agent to image the liver asialoglycoprotein receptors and quantify hepatic liver function in various diseases. A lactosylated protein (LACTAL) conjugate showed excellent liver uptake compared to non-lactosylated protein and a high signal to noise ratio, based on the biodistribution in mice using Tc-scintigraphy. However, in the laboratory, it is useful to have a method that can be used in daily practice to quantify cellular targeting or biodistribution. Read More

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http://dx.doi.org/10.1016/j.nano.2019.02.011DOI Listing

Chronic administration of nano-sized PAMAM dendrimers in vivo inhibits EGFR-ERK1/2-ROCK signaling pathway and attenuates diabetes-induced vascular remodeling and dysfunction.

Nanomedicine 2019 Mar 4;18:78-89. Epub 2019 Mar 4.

Department of Pharmacology and Therapeutics, Faculty of Pharmacy, Kuwait University. Electronic address:

We investigated whether chronic administration of nano-sized polyamidoamine (PAMAM) dendrimers can have beneficial effects on diabetes-induced vascular dysfunction by inhibiting the epidermal growth factor receptor (EGFR)-ERK1/2-Rho kinase (ROCK)-a pathway known to be critical in the development of diabetic vascular complications. Daily administration of naked PAMAMs for up to 4 weeks to streptozotocin-induced diabetic male Wistar rats inhibited EGFR-ERK1/2-ROCK signaling and improved diabetes-induced vascular remodeling and dysfunction in a dose, generation (G6 > G5) and surface chemistry-dependent manner (cationic > anionic > neutral). PAMAMs, AG1478 (a selective EGFR inhibitor), or anti-EGFR siRNA also inhibited vascular EGFR-ERK1/2-ROCK signaling in vitro. Read More

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http://dx.doi.org/10.1016/j.nano.2019.02.012DOI Listing
March 2019
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Surface engineering of LENS-Ti-6Al-4V to obtain nano- and micro-surface topography for orthopedic application.

Nanomedicine 2019 Mar 4;18:157-168. Epub 2019 Mar 4.

Centre for Biomaterials, Cellular and Molecular Theranostics (CBCMT), VIT University, Vellore, TN, India. Electronic address:

Two distinct surface topographies consisting of micro- and nano-surface were developed using laser texturing (LT) and anodization process respectively and their effect on the surface-related properties of Ti-6Al-4V fabricated using Laser Engineered Net Shaping (LENS) were determined. The topographies developed using laser texturing (25, 50 and 75% overlap) were examined using 3D profilometer, whereas, Field Emission Scanning Electron Microscopy (FE-SEM) was used to analyze Titania NanoTubes (TNT) formed using anodization. Though all the surface modified specimens exhibited hydrophilic behavior, least contact angle values were observed for the specimen surface modified with TNT. Read More

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https://linkinghub.elsevier.com/retrieve/pii/S15499634193004
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http://dx.doi.org/10.1016/j.nano.2019.02.010DOI Listing
March 2019
4 Reads

Temporal-controlled bioactive molecules releasing core-shell nano-system for tissue engineering strategies in endodontics.

Nanomedicine 2019 Mar 4;18:11-20. Epub 2019 Mar 4.

Dental Research Institute, Faculty of Dentistry, University of Toronto, Toronto, Ontario, Canada. Electronic address:

Temporal-controlled release of bioactive molecules is of key importance in the clinical translation of tissue engineering techniques. We engineered a core-shell nano-system (TD-NS) that sequentially released transforming growth factor-β1 (TGF-β1), a chemotactic/proliferating growth factor and dexamethasone (Dex), an osteo/odontogenic agent in a temporal-controlled manner. In stage-1, there was a rapid release of TGF-β1, reaching a concentration of 2 ng/mL of TGF-β1 in 7 days to 14 days, which tapers subsequently. Read More

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https://linkinghub.elsevier.com/retrieve/pii/S15499634193004
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http://dx.doi.org/10.1016/j.nano.2019.02.013DOI Listing
March 2019
11 Reads

Phototherapy using immunologically modified carbon nanotubes to potentiate checkpoint blockade for metastatic breast cancer.

Nanomedicine 2019 Mar 4;18:44-53. Epub 2019 Mar 4.

Biophotonics Research Laboratory, Center for Interdisciplinary Biomedical Education and Research, College of Mathematics and Science, University of Central Oklahoma, Edmond, OK, USA. Electronic address:

Metastasis is the major cause of cancer-death. Checkpoint inhibition shows great promise as an immunotherapeutic treatment for cancer patients. However, most currently available checkpoint inhibitors have low response rates. Read More

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http://dx.doi.org/10.1016/j.nano.2019.02.009DOI Listing
March 2019
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Immunostimulatory cytokine and doxorubicin co-loaded nanovesicles for cancer immunochemotherapy.

Nanomedicine 2019 Mar 2;18:66-77. Epub 2019 Mar 2.

Tongji School of Pharmacy, HuaZhong University of Science and Technology, Wuhan, China; National Engineering Research Center for Nanomedicine, HuaZhong University of Science and Technology, Wuhan, China; Hubei Engineering Research Center for Novel Drug Delivery System, HuaZhong University of Science and Technology, Wuhan, China. Electronic address:

Taking advantages of drug delivery system, immunostimulatory and chemotherapeutic agents with different physiochemical properties can be co-delivered to realize synergistic antitumor effect. Here the immunostimulatory cytokine interleukin-2 (IL-2) was firstly adsorbed in doxorubicin (DOX) loaded nanovesicles (NV-DOX) with high encapsulation efficiency by a facile solvent free method. After intravenous injection to melanoma bearing mice, NV-DOX can accumulate in tumor and remarkably suppress tumor growth with negligible systemic toxicity. Read More

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http://dx.doi.org/10.1016/j.nano.2019.02.008DOI Listing
March 2019
4 Reads

Cationic lipoplexes for treatment of cancer stem cell-derived murine lung tumors.

Nanomedicine 2019 Mar 1;18:31-43. Epub 2019 Mar 1.

College of Pharmacy and Pharmaceutical Sciences, Florida A&M University, Tallahassee, FL 32307, USA. Electronic address:

Side population (SP) cells with stem-like properties, also known as cancer stem cells (CSC) have been recognized as drivers of the resistance phenotype in many cancers. Central to the characteristic stem-like phenotype of CSCs in cancer is the activity of the SOX2 transcription factor whose upregulation has been associated with enrichment of many oncogenes. This study outlines the fabrication of a lipoplex of SOX2 small interfering RNA (CL-siSOX2) for targeted treatment of SOX2-enriched, CSC-derived orthotopic and xenograft lung tumors in CB-17 SCID mice. Read More

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http://dx.doi.org/10.1016/j.nano.2019.02.007DOI Listing
March 2019
1 Read