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    Whole exome sequencing reveals novel somatic alterations in neuroblastoma patients with chemotherapy.
    Cancer Cell Int 2018 17;18:21. Epub 2018 Feb 17.
    1Beijing Key Laboratory of Pediatric Hematology Oncology, National Discipline of Pediatrics, Ministry of Education, MOE Key Laboratory of Major Diseases in Children, Hematology Oncology Center, Beijing Children's Hospital, Capital Medical University, National Center for Children's Health, No. 56 Nanlishi Road, Beijing, 100045 China.
    Background: We ought to explore the acquired somatic alterations, shedding light on genetic basis of somatic alterations in NB patients with chemotherapy.

    Methods: Marrow blood samples from NB patients were collected before treatment, after the 2nd and 4th chemotherapy for baseline research and continuous monitoring by whole exome sequencing. Plasma cell free DNA (cfDNA) was prepared for baseline research. Read More

    Patient Mortality in Geriatric Distal Femur Fractures.
    J Orthop Trauma 2018 Mar;32(3):111-115
    OrthoIndy Trauma, St. Vincent Trauma Center, St. Vincent Orthopedics and Spine Center, Indianapolis, IN.
    Objectives: To estimate 1-year mortality rates in elderly patients who undergo operative treatment for distal femur fractures and identify potential risk factors for mortality.

    Design: Retrospective chart review.

    Setting: Level 1 and Level 2 trauma centers. Read More

    Absolute Versus Relative Fracture Fixation: Impact on Fracture Healing.
    J Orthop Trauma 2018 Mar;32 Suppl 1:S12-S16
    Orthopedic Surgery, BayCare Medical Group, St. Joseph's Hospital-North, Lutz, FL.
    The goals of all orthopaedic surgeons treating fractures are, and will remain, obtaining union of the fracture with a well-aligned and functional limb while minimizing the risk of complications. This requires us to understand how the biomechanical environment of the fracture affects healing and to be able to discern which mechanical environment is preferred over another. Understanding the spectrum of stability imparted by our current surgical devices is paramount to giving our patients the best opportunity to heal and recover from their injury. Read More

    Clinical analysis of peri-operative hidden blood loss of elderly patients with intertrochanteric fractures treated by unreamed proximal femoral nail anti-rotation.
    Sci Rep 2018 Feb 19;8(1):3225. Epub 2018 Feb 19.
    Department of Orthopedics, West China Hospital, Sichuan University, 37# Wainan Guoxue Road, Chengdu, 610041, People's Republic of China.
    The purpose of this study was to quantify the peri-operative blood loss of elderly patients with intertrochanteric fractures treated by unreamed proximal femoral nail anti-rotation (PFNA) and analyze whether the substantial hidden blood loss was induced by initial trauma or the operation. The clinical data of 123 patients with intertrochanteric fracture treated with unreamed PFNA from Jan 2013 to Apr 2017 were analyzed retrospectively. Blood routine on admission day (ADM), pre-operative day one (PRE), post-operative days one and three (POD1 and POD3) and the visible blood loss (VBL) were obtained. Read More

    [Multi-point fixation with absorbable cartilage screws for the treatment of osteochondral fracture caused by patellar instability].
    Zhongguo Gu Shang 2017 Nov;30(11):991-993
    Department of Joint Surgery, the 371th Central Hospital of PLA, Xinxiang 453000, Henan, China.
    Objective: To study clinical effects of multi-point fixation with bioabsorbable cartilage screws for the treatment of osteochondral fracture caused by patellar instability.

    Methods: During the period from August 2014 to Steptember 2016, there were 21 patients with osteochondral fracture caused by patellar dislocation, including 7 males and 14 females, ranging in age from 12 to 42 years old, with an average of 27 years old. During the operation, free fractures fragments of cartilage were found with a open surgery, and the patients were treated with fixation by absorbable cartilage screws combined with lateral retinaculum release and medial retinaculum shrinkage. Read More

    HAS A GLOMUS TUMOR ALWAYS A QUICK DIAGNOSIS?
    Acta Chir Plast 2017 ;59(2):82-84
    Introduction: Glomus tumor is a rare and benign vascular tumor. Although symptoms specific for this tumor are quite clear, there is still a delay between the onset of symptoms, diagnosis and subsequent surgical therapy. The authors monitor the time from the onset of symptoms to the diagnosis and management of the problems. Read More

    A new perspective on the nail plate for treatment of ingrown toenail.
    Dermatol Pract Concept 2018 Jan 31;8(1):22-27. Epub 2018 Jan 31.
    Department of Hand Surgery, Union Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, P.R. China.
    Background: Our routine treatment for ingrown toenail was removal of the surrounding soft tissue and shortening the bone of the distal phalanx. We determined the range and volume of excision based on our experience without an objective standard and routinely performed avulsion of the nail plate.

    Objective: To take the nail plate as an objective mark during surgical treatment of ingrown toenail to ensure accurate excision. Read More

    Mid-term follow-up of patients with hindfoot arthrodesis with retrograde compression intramedullary nail in Charcot neuroarthropathy of the hindfoot.
    Bone Joint J 2018 Feb;100-B(2):190-196
    Orthopaedic Hospital Speising, Speisingerstrasse 109, A-1130, Vienna, Austria.
    Aims: Hindfoot arthrodesis with retrograde intramedullary nailing has been described as a surgical strategy to reconstruct deformities of the ankle and hindfoot in patients with Charcot arthropathy. This study presents case series of Charcot arthropathy patients treated with two different retrograde intramedullary straight compression nails in order to reconstruct the hindfoot and assess the results over a mid-term follow-up.

    Patients And Methods: We performed a retrospective analysis of 18 consecutive patients and 19 operated feet with Charcot arthropathy who underwent a hindfoot arthrodesis using a retrograde intramedullary compression nail. Read More

    Time-resolved fluorescence spectroscopy for the diagnosis of oral lichen planus.
    Clin Exp Dermatol 2018 Feb 13. Epub 2018 Feb 13.
    Department of Dermatology, Davis Medical Center, University of California-Davis, Sacramento, CA, USA.
    Background: Lichen planus (LP) is a T-cell mediated autoimmune disorder of unknown aetiology that affects the skin, nails, oral and genital mucous membranes. Conventionally, oral LP (OLP) is diagnosed through clinical assessment and histopathological confirmation by oral biopsy.

    Aim: To explore the use of time-resolved fluorescence spectroscopy (TRFS) to detect fluorescence lifetime changes between lesional OLP and perilesional normal mucosa. Read More

    Risk factors of fixation failure in basicervical femoral neck fracture: Which device is optimal for fixation?
    Injury 2018 Feb 9. Epub 2018 Feb 9.
    Department of Orthopaedic Surgery, Seoul National University Bundang Hospital, Seongnam, South Korea. Electronic address:
    Background: Basicervical femur neck fracture (FNF) is a rare type of fracture, and is associated with increased risk of fixation failure due to its inherent instability. The purpose of this study was (1) to investigate the incidence of fixation failure and (2) to determine risk factors for fixation failure in basicervical FNF after internal fixation.

    Methods: To identify basicervical FNF with a minimum of 12 months follow-up, we retrospectively reviewed records of 3217 patients who underwent hip fracture surgery from May 2003 to March 2016. Read More

    Evaluation of Intramedullary Fixation for Pediatric Femoral Shaft Fractures in Developing Countries.
    J Orthop Trauma 2018 Jan 24. Epub 2018 Jan 24.
    Division of Pediatric Orthopaedic Surgery Case Western Reserve University Rainbow Babies and Children's Hospital 11100 Euclid Avenue, RBC 6081 Cleveland, OH 44106.
    Objectives: To report the clinical results following treatment of pediatric femoral shaft fractures with the SIGN Fracture Care International (SIGN) pediatric and standard fin nails.

    Design: Retrospective review of prospectively collected data SETTING:: Sixteen global SIGN centers from 2003-2013 PATIENTS/PARTICIPANTS:: One hundred and twelve pediatric patients who sustained a diaphyseal pediatric femoral shaft fracture INTERVENTION:: Intramedullary fixation with the standard or pediatric SIGN nail MAIN OUTCOME MEASUREMENTS:: Main outcome measurements include clinical and radiographic healing and postoperative complications RESULTS:: The mean age of the pediatric fin patients was 9.4 years (4 to 15) and 11. Read More

    Helical blade or the integrated lag screws: a matched pair analysis of 100 patients with unstable trochanteric fractures.
    J Orthop Trauma 2018 Feb 9. Epub 2018 Feb 9.
    Dept of Orthopaedics, Parvathy Hospital, Chennai.
    Objectives: To compare the radiological and clinical results with PFNA - II and InterTan in the treatment of unstable trochanteric fractures in the elderly DESIGN:: Retrospective, multi-center, matched pair SETTING:: 3 tertiary level trauma centres PATIENTS:: 100 elderly patients who underwent intramedullary stabilisation with either the PFNA - II or the InterTan for osteoporotic unstable trochanteric fractures.

    Interventions: 50 matched pairs consisting of AO - A2 and A3 fractures were created from a cohort of 290 patients who underwent internal fixation for unstable trochanteric fractures with the PFNA - II or InterTan nails.

    Outcome Measurements: Radiological assessment was performed to compare union rates, varus collapse, medial or lateral screw/blade migration and cut-out. Read More

    [Comparative study of proximal femoral nail anti-rotation and dynamic hip screw in the unstable intertrochanteric fractures in the elderly].
    Zhonghua Yi Xue Za Zhi 2018 Jan;98(5):357-361
    Department One of Orthopedics, the Fifth Affiliated Hospital of Xinjiang Medical University, Urumqi 830011, China.
    To compare the effect of proximal femoral nail anti-rotation and dynamic hip screw in treating the femoral intertrochanteric fractures in elderly patients.From June 2011 to June 2014, totally 158 elderly patients of femoral intertrochanteric fracture were treated by surgery, among whom 68 cases were treated with dynamic hip screws (DHS), and 90 patients were treated with proximal femoral nail anti-rotation (PFNA). The operative time, hospitalization time, weight-bearing time, fracture-healing time, blood loss and the hip function score after the operation were compared between the two groups by using thetest; and the incidence of the postoperative complication was compared between the two groups by using the Chi square test. Read More

    Comparison between locked and unlocked intramedullary nails in intertrochanteric fractures.
    Eur J Orthop Surg Traumatol 2018 Feb 9. Epub 2018 Feb 9.
    U.O.C. Orthopedics and Traumatology Department, SM Misericordia Hospital, University of Perugia, Perugia, Italy.
    Background: Intertrochanteric fractures are of great interest worldwide and are the most frequently operated fractures. Intramedullary nailing is commonly used in the treatment of intertrochanteric fractures. The purpose of this study is to assess the necessity of using the distal blocking screw in 31-A1 and 31-A2 fractures, classified according to the Orthopaedic Trauma Association classification system (AO/OTA). Read More

    The effect of tranexamic acid on hidden bleeding in older intertrochanteric fracture patients treated with PFNA.
    Injury 2018 Feb 2. Epub 2018 Feb 2.
    Department of Orthopaedic Surgery, The Third Hospital of Hebei Medical University, No.139 Ziqiang Road, Shijiazhuang 050051, Hebei, PR China; Key Laboratory of Biomechanics of Hebei Province, Shijiazhuang 050051, Hebei, PR China. Electronic address:
    Objective: To investigate the effect of tranexamic acid (TXA) on hidden bleeding in older intertrochanteric fracture patients treated with intramedullary nails.

    Method: Between January 2016 and January 2017, 100 cases of intertrochanteric fractures eligible for the study were treated with proximal femoral nail antirotation (PFNA) in our hospital. All patients were divided into two groups of 50 patients each: the TXA group and a blank control group. Read More

    [Clinical analysis of LPFP, PFNA and BPH in treating femoral intertrochanteric fractures in elderly patients].
    Zhongguo Gu Shang 2017 Jul;30(7):607-611
    Department of Joint Surgery, the Affiliated Hospital of Qiingdao University, Qingdao 266000, Shandong, China;
    Objective: To evaluate the clinical results of locking proximal femur plate(LPFP), proximal femoral nail antirotation(PFNA) and bipolar hemiarthroplasty(BPH) in the treatment of femoral intertrochanteric fractures in elderly patients.

    Methods: Retrospective analysis of the 86 elderly patients with femoral intertrochanteric fractures during June 2011 and August 2016 were enrolled in this study. The patients were divided into 3 groups: 26 cases in LPFP group included 10 males and 16 females with an average age of (72. Read More

    [Comparison of PFNA and InterTAN intramedullary nail in treating unstable femoral intertrochanteric fractures].
    Zhongguo Gu Shang 2017 Jul;30(7):597-601
    Department of Orthopaedics, Changhai Hospital of Second Military Medical University, Shanghai 200433, China;
    Objective: To compare the clinical effects of PFNA and InterTAN for the treatment of unstable intertrochanteric fractures in the elderly patients.

    Methods: From April 2012 to February 2014, 113 elderly patients with unstable intertrochanteric fractures were treated by PFNA or InterTAN. There were 64 cases in PFNA group, including 25 males and 39 females with an average age of (73. Read More

    Management of penetrating brain injury caused by nail guns: three case reports and literature review.
    World Neurosurg 2018 Jan 30. Epub 2018 Jan 30.
    Department of Neurosurgery, The Third Affiliated Hospital of Soochow University, No.185, Juqian Road, Changzhou City, 213003, China. Electronic address:
    Background: Penetrating brain injury (PBI) caused by a nail gun is an extremely rare neurosurgical emergency that poses a challenge for neurosurgeons because of its rarity and complexity.

    Case Description: In this article, we present three cases of PBI caused by nail guns. In the first, the nail entered through the right parietal bone and lodged in the right parietal lobe and basal ganglia. Read More

    Complications of Intramedullary Fixation for Distal Radius Fractures in Elderly Patients: A Retrospective Analysis Using McKay's Complication Checklist.
    J Hand Surg Asian Pac Vol 2018 Mar;23(1):71-75
    † Department of Orthopedic Surgery, Tokyo Medical and Dental University, Tokyo, Japan.
    Background: Intramedullary fixation for distal radius fractures is reported to be free of hardware irritation and less invasive than other fixation methods. Some specific complications associated with intramedullary fixation, such as radial nerve sensory neuritis, have been reported, but no study has focused on the complication rates of intramedullary fixation for distal radius fractures in the elderly population. Furthermore, no studies have analyzed common complications, such as carpal tunnel syndrome and flexor tenosynovitis including trigger finger, among patients with distal radius fractures treated by intramedullary fixation based on a comprehensive complication checklist. Read More

    Lateral malleolus closed reduction and internal fixation with intramedullary fibular rod using minimal invasive approach for the treatment of ankle fractures.
    Foot Ankle Surg 2017 Sep 7. Epub 2017 Sep 7.
    Department of Orthopedic Surgery, Chaim Sheba Medical Center at Tel Hashomer, Affiliated to the Sackler Faculty of Medicine, Tel Aviv University, Ramat Gan, 5262100 Tel Aviv, Israel. Electronic address:
    Background: Ankle fractures are extremely common and represent nearly one quarter of all lower-limb fractures. Techniques for fixation of displaced fractures of the lateral malleolus have remained essentially unchanged in recent decades. The current gold standard of treating unstable fractures is with open reduction and internal fixation (ORIF), using plates and screws construct. Read More

    Uncontrolled diabetes as a potential risk factor in tibiotalocalcaneal fusion using a retrograde intramedullary nail.
    Foot Ankle Surg 2017 Jul 22. Epub 2017 Jul 22.
    Department of Orthopaedic Surgery, Yonsei University College of Medicine, Republic of Korea. Electronic address:
    Background: Tibiotalocalcaneal (TTC) fusion using a retrograde intramedullary (IM) nail is an effective salvage option for terminal-stage hindfoot problems. However, as many patients who receive TTC fusion bear unfavorable medical comorbidities, the risk of nonunion, infection and other complications increases. This study was performed to identify the factors influencing outcomes after TTC fusion using a retrograde IM nail. Read More

    Use of intramedullary carbon fiber nail in hindfoot fusion: A small cohort study.
    Foot Ankle Surg 2017 Jul 29. Epub 2017 Jul 29.
    University of Alabama at Birmingham, Department of Surgery - Orthopaedic Division, 1313 13th Street South, Birmingham, AL 35205, USA. Electronic address:
    Background: Current literature on carbon fiber implant use in foot and ankle surgery is scant. The purpose of this paper is to report medium-term outcomes of hindfoot fusion using a carbon fiber intramedullary nail.

    Methods: We retrospectively reviewed 30 cases of hindfoot fusion using carbon fiber intramedullary nail fixation between 2014 and 2017. Read More

    Functional pedal construct achieved by combined operative treatment in peritalar complex Charcot arthropathy: A prospective study of 38 feet.
    Foot Ankle Surg 2017 Mar 6. Epub 2017 Mar 6.
    Mansoura University Hospital, Mansoura Faculty of Medicine, 35516 Mansoura, Egypt.
    Background: Charcot arthropathy of the peritalar complex carries a high risk of amputation if not properly managed. Our aim is to assess the functional outcome of severe Charcot arthropathy of the peritalar complex following enblock resection of the ulcer, massive debridement and stabilizing all the elements of the peritalar complex.

    Methods: We prospectively studied 38 feet in 35 patients with peritalar complex Charcot arthropathy. Read More

    Tibiotalocalcaneal nail fixation and soft tissue coverage of Gustilo-Anderson grade 3B open unstable ankle fractures in a frail population; a case series in a major trauma centre.
    Foot Ankle Surg 2017 Apr 13. Epub 2017 Apr 13.
    Southmead Hospital, Southmead Road, Westbury-on-Trym, Bristol BS10 5NB, United Kingdom. Electronic address:
    Background: Gustilo-Anderson grade 3B open ankle fracture-dislocations requiring stable fixation and soft tissue coverage are increasingly common in frail populations.

    Methods: We identified all patients with open ankle fracture-dislocations treated with a tibiotalocalcaneal nail and soft tissue coverage over a five-year period. We retrospectively recorded pre-morbid status, fracture and soft tissue injury pattern, surgical details, post-operative mobility, length of hospital stay, complication and re-operation rate and survival. Read More

    Reconstruction of bone defect with allograft and retrograde intramedullary nail for distal tibia osteosarcoma.
    Foot Ankle Surg 2017 Feb 4. Epub 2017 Feb 4.
    Department of Orthopedic Surgery, The Affiliated Drum Tower Hospital of Nanjing University Medical School, China. Electronic address:
    Background: To investigate the effectiveness of tibiotalocalcaneal arthrodesis with a retrograde nail and allograft in limb salvage surgery for patients with distal tibia osteosarcoma.

    Methods: 5 patients diagnosed as distal tibia osteosarcoma underwent ankle arthrodesis with a retrograde nail in our hospital. During the follow-up, radiographic views of the ankle joint were taken in two planes to assess bone healing and axis alignment. Read More

    Comparison of the outcomes of pediatric tibial shaft fractures treated by different types of orthopedists: A prospective cohort study.
    Int J Surg 2018 Jan 30. Epub 2018 Jan 30.
    Department of Orthopaedic Surgery, The Second Affiliated Hospital and Yuying Children's Hospital of Wenzhou Medical University, Wenzhou 325000, China. Electronic address:
    Background: The objective of this study was to compare the outcomes of pediatric tibial shaft fractures treated with titanium elastic nail (TEN) by pediatric orthopedists and non-pediatric orthopedists.

    Materials And Methods: We conducted a prospective cohort study of 90 children of tibial shaft fractures, who were randomized to operative stabilization either by pediatric orthopedists (Group A, 45 cases) or by non-pediatric orthopedists (Group B, 45 cases) from April 2010 to May 2015. Demographic data and clinical characteristics (age, sex, weight, fracture side and type, cause of injury, number of fibula fracture and time from injury to operation) were comparable between the two groups before surgery. Read More

    Minimizing Leg Length Discrepancy After Intramedullary Nailing Of Comminuted Femoral Shaft Fractures: A Prospective Quality Improvement Initiative Using The Scout CT Scanogram.
    J Orthop Trauma 2018 Jan 30. Epub 2018 Jan 30.
    Detroit Medical Center/ Wayne State University Detroit, MI, USA 9B University Health Center Detroit Receiving Hospital 4201 St. Antoine Blvd.Detroit, Michigan 48201.
    Objectives: To prevent leg length discrepancy (LLD) after locked femoral nailing in patients with comminuted femoral shaft fractures.

    Design: Prospective consecutive case series aimed at quality improvement SETTING:: Level 1 Trauma Center USA PATIENTS:: Ninety-eight consecutive patients with a comminuted femoral shaft fracture underwent statically locked intramedullary nailing with a focused attempt at minimizing LLD during surgery.

    Intervention: A CT scanogram of both legs was performed on post op day 1 to assess for residual LLD . Read More

    Nail Fit: Does Nail Diameter to Canal Ratio Predict the Need for Exchange Nailing in the Setting of Aseptic, Hypertrophic Femoral Nonunions?
    J Orthop Trauma 2018 Jan 26. Epub 2018 Jan 26.
    Department of Orthopaedic Surgery, The Alfred Hospital, Melbourne VIC, Australia.
    Objectives: To evaluate patient independent risk factors of aseptic femoral hypertrophic nonunion requiring exchange nailing, with particular reference to the fit of the nail at the isthmus within the canal.

    Design: Retrospective case control study SETTING:: Level 1 trauma centre MAIN OUTCOME MEASUREMENTS:: Between 2008-2012, 211 patients without any patient-dependent risk factors for nonunion were treated with a locked reamed intramedullary nail for a femoral shaft fracture. 23 cases went on to hypertrophic nonunion requiring exchange nailing (treatment group) and 188 cases went on to union (control group). Read More

    Proximal Humerus Fractures: Evaluation and Management in the Elderly Patient.
    Geriatr Orthop Surg Rehabil 2018 25;9:2151458517750516. Epub 2018 Jan 25.
    Department of Orthopaedics and Sports Medicine, University of Cincinnati, Cincinnati, OH, USA.
    Introduction: Proximal humerus fractures are common in the elderly. The evaluation and management of these injuries is often controversial. The purpose of this study is to review recent evidence and provide updated recommendations for treating proximal humerus fractures in the elderly. Read More

    Predictors for perioperative blood transfusion in elderly patients with extra capsular hip fractures treated with cephalo-medullary nailing.
    Chin J Traumatol 2018 Feb 8;21(1):16-19. Epub 2017 Dec 8.
    Royal Free NHS Foundation Trust, The Ridgeway, Enfield, EN2 8JL, United Kingdom.
    Purpose: The aim of our study was to determine predictive factors and requirement for perioperative blood transfusion in elderly patients with extra capsular hip fractures treated with cephalo-medullary device.

    Methods: Seventy-nine patients with extra capsular hip fractures treated with cephalo-medullary nailing were included in the study. Age, sex, ASA grade, timing of surgery, preoperative and postoperative haemoglobin, length of hospital stay, fracture type, number of units transfused and 30-day mortality were recorded. Read More

    The antegrade angle-stable locking intramedullary nail for type-C distal femoral fractures: a thirty four case experience.
    Int Orthop 2018 Feb 3. Epub 2018 Feb 3.
    First Department of Orthopaedics, Tianjin Fourth Central Hospital, Tianjin, 300140, People's Republic of China.
    Introduction: This is a retrospective study that provides initial experience and verifies the effectiveness of the newly-designed antegrade interlocking angle-stable intramedullary nail (IAIN) combined with half-threaded cancellous screws in the management of type-C (AO/OTA classification) distal femoral fractures.

    Methods: During a period of 30 months, 34 patients (mean age 43.1 years) with type-C (AO/OTA classification) fractures of the distal femur were treated with IAIN and half-threaded cancellous screws were reviewed. Read More

    Intramedullary nailing in opening wedge high tibial osteotomy-in vitro test for validation of a method of fixation.
    Int Orthop 2018 Feb 1. Epub 2018 Feb 1.
    Department of Mechanical Engineering, University of Siegen, Paul-Bonatz-Str. 9-11, 57076, Siegen, Germany.
    Purpose: Opening wedge high tibial osteotomy (HTO) as a treatment in unicompartimental osteoarthritis of the knee can significantly relieve pain and prevent or at least delay an early joint replacement. The fixation of the osteotomy has undergone development and refinements during the last years. The angle-stable plate fixator is currently one of the most commonly used plates in HTOs. Read More

    Toe keloid after nail extraction treated with surgical excision: A case report.
    Medicine (Baltimore) 2017 Dec;96(51):e9373
    Department of Plastic Surgery, Peking Union Medical College Hospital.
    Rationale: In this study, a case of toe keloid after nail extraction is presented, in which the keloids on both toes were resected by surgical excision. Keloids (from the Greek word meaning "crab's claw") are fibrous growths that extend beyond the original area of injury to involve the adjacent normal skin. In general, keloid tendencies appear to be regionally isolated to keloid-prone areas, such as the chest, ears, and deltoid regions, whereas the hands and feet are usually spared, which is why this case is meaningful. Read More

    The relationship between the expression of TN and the efficiency of posterior spinal V osteotomy in patients with traumatic kyphosis.
    Medicine (Baltimore) 2018 Feb;97(5):e9555
    Department of Orthopedics, Zhejiang Rongjun Hospital, Jiaxing, Zhejiang Province.
    Background: This study was conducted with the aim to investigate the relationship between Tetranectin (TN) and efficiency of posterior spinal V osteotomy in patients with traumatic kyphosis.

    Methods: Ninety-two patients with traumatic kyphosis admitted in our hospital from February 2014 to June 2016 were included whose serum TN levels were examined by ELISA. Using the mean level of TN as cut-off value, patients were classified into TN high level group (group I) and TN low level group (group II). Read More

    Osteopoikilosis found incidentally in a 17-year-old adolescent with femoral shaft fracture: A case report.
    Medicine (Baltimore) 2017 Nov;96(47):e8650
    Department of Orthopedics, The First Affiliated Hospital of Nanchang University. Artificial Joints Engineering and Technology Research Center of Jiangxi Province, Nanchang, Jiangxi, China.
    Rationale: Osteopoikilosis is a rare and asymptomatic disease of the bone, which is often discovered occasionally on radiography for irrelevant complaints. Characterized by multiple, small, circular, or oval-shaped radiodense lesions, it may be confused with bony metastatic tumors.

    Patient Concerns: The present study describes a case of a 17-year-old adolescent who suffered from pain and movement limitation of his left thigh following a fall from standing height. Read More

    Corrective osteotomy with retrograde Fassier-Duval nail in an osteogenesis imperfecta patient with bilateral genu valgum: A case report.
    Medicine (Baltimore) 2017 Nov;96(47):e8459
    Department of Orthopedics, Mackay Memorial Hospital Medical Center, New Taipei City, Taiwan, R.O.C.
    Rationale: The treatment of osteogenesis imperfecta (OI) requires a multidisciplinary approach to maximize function and reduce fracture incidence. The aim of this case report was to discuss an alternative surgical approach to stabilize a corrective osteotomy using the Fassier Duval (FD) system in an OI patient.

    Patient Concerns: A 20-year-old OI woman presented with left thigh pain, gait disturbance, and bilateral genu valgus deformities. Read More

    Myxoid Cyst as a Probable Complication of Nail Surgery.
    Dermatol Surg 2018 Jan 29. Epub 2018 Jan 29.
    Dermatology Professionals, Inc., East Greenwich, Rhode Island Dermatology Professionals, Inc., East Greenwich, Rhode Island Department of Dermatology, University of Massachusetts Medical School, Worcester, Massachusetts Department of Dermatology, The Warren Alpert Medical School at Brown University, Providence, Rhode Island.

    Initial peri- and postoperative antibiotic treatment of infected nonunions: results from 212 consecutive patients after mean follow-up of 34 months.
    Ther Clin Risk Manag 2018 4;14:59-67. Epub 2018 Jan 4.
    Department of Orthopaedics, Trauma Surgery and Paraplegiology.
    Purpose: Infected nonunions of the long bones belong to the most feared complications in the field of orthopedic and trauma surgery. Optimal antibiotic therapy should start early with the first revision surgery. Therefore, the aim of this study was to evaluate our peri- and postoperative antibiotic regime in context with the microbial spectrum and antibiotic resistances of patients with infected nonunions and to assess the possible impact on healing rates. Read More

    Does the Angle of the Nail Matter for Pertrochanteric Fracture Reduction? Matching Nail Angle and Native Neck-Shaft-Angle.
    J Orthop Trauma 2017 Nov 20. Epub 2017 Nov 20.
    Department of Orthopaedic Surgery, Mayo Clinic, Rochester, MN, USA.
    Objectives: To determine if fixation of pertrochanteric hip fractures with cephalomedullary nails (CMN) with a neck-shaft angle (NSA) less than the native NSA affects reduction and lag screw cutout.

    Design: Retrospective comparative study SETTING:: Level one trauma center PATIENTS/PARTICIPANTS:: Patients treated with a CMN for unstable pertrochanteric femur fractures (OTA/AO 31-A2.2 and 31-A2. Read More

    Endosteal Substitution With an Intramedullary Rod in Fractures of the Femur.
    J Orthop Trauma 2018 Feb;32 Suppl 1:S25-S29
    Department of Orthopaedic Surgery and Rehabilitation, University of Mississippi Medical Center, Jackson, MS.
    Background: Morbid obesity and segmental fracture/bone loss are challenging problems in the treatment of fractures and nonunions of the distal femur. The use of an intramedullary rod as an endosteal substitute for a deficient medial cortex along with a lateral locked plate is 1-tool to combat these problems. This article describes the technique used and its results at a single Level 1 trauma center. Read More

    Intraosseous Plating for the Management of Cortical Defects.
    J Orthop Trauma 2018 Feb;32 Suppl 1:S12-S17
    Department of Orthopaedic Surgery and Rehabilitation, University of Mississippi Medical Center, Jackson, MS.
    The management of fractures with segmental bone loss or abundant comminution on the far cortex is often complicated by deformity or frank hardware failure. Using plate constructs that rely on off-axis loading may not be sufficient to support the limb until healing occurs. There are a number of techniques to mitigate this problem, notably the use of intramedullary nails and bicolumnar plating of the fracture. Read More

    Oncological and functional results after surgical treatment of bone metastases at the proximal femur.
    BMC Surg 2018 Jan 25;18(1). Epub 2018 Jan 25.
    Department of Orthopaedic Oncology, Specialist Hospital in Brzozów- Podkarpacie Oncology Centre, Bielawskiego 18, 36-200, Brzozów, Poland.
    Background: Metastatic lesions to the proximal femur occur frequently (about 10% of patients with cancer) and require surgical treatment. There are many surgical methods of treatment, however, use of the tumor modular endoprostheses seems to be particularly promising. The aim of study was to evaluate oncological and functional results of treatment in patients with proximal femur metastases. Read More

    [Complications after intramedullary stabilization of clavicle fractures].
    Unfallchirurg 2018 Jan 24. Epub 2018 Jan 24.
    Klinik für Unfall‑, Plastische und Wiederherstellungschirurgie, Universitätsklinikum Ulm, Albert- Einstein-Allee 23, 89081, Ulm, Deutschland.
    Background: Operative treatment of clavicle fractures by intramedullary nailing with titanium elastic nailing (TEN) has been established as an alternative to plate osteosynthesis for many years. The main complication after TEN osteosynthesis is nail migration. The goal of this study was evaluation of predictors for medial nail migration and comparison with plate osteosynthesis. Read More

    Comparison of three surgical fixation methods for dual-bone forearm fractures in older children: A retrospective cohort study.
    Int J Surg 2018 Feb 1;51:10-16. Epub 2018 Feb 1.
    Department of Orthopaedic Surgery, The Second Affiliated Hospital and Yuying Children's Hospital of Wenzhou Medical University, Wenzhou 325000, China. Electronic address:
    Background: The aim of this study was to compare the outcomes of dual ESIN (D-ESIN) fixation, hybrid fixation, and open reduction and dual plate (d-plate) fixation in the treatment of dual-bone forearm fractures in children aged 10-16 years.

    Materials And Methods: 137 patients with dual-bone forearm fractures (48 patients in the D-ESIN group, 45 patients in the hybrid group, and 44 patients in the d-plate group) were reviewed. Duration of surgery, length of incision, intraoperative blood loss, intraoperative times of fluoroscopy, and duration of postoperative immobilisation were recorded. Read More

    Mortality in patients sustaining a periprosthetic fracture following a previous extracapsular hip fracture fixation.
    Injury 2018 Jan 2. Epub 2018 Jan 2.
    Department of Trauma and Orthopaedics, Plymouth Hospitals NHS Trust, Derriford Rd., Crownhill, Plymouth, PL6 8DH, United Kingdom. Electronic address:
    Background: Mortality rates following hip fractures are decreasing. As these outcomes improve, it increases the potential for further falls and the potential to sustain a periprosthetic fracture. The aim of this study was to analyse the 1 year mortality of periprosthetic fractures around an implant used to treat an extracapsular hip fracture. Read More

    Nail psoriasis treated with pulsed dye laser.
    An Bras Dermatol 2017 Nov-Dec;92(6):885-887
    Dermatology Service, Porto Alegre University Hospital at the Federal University of Rio Grande do Sul (HCPA-UFRGS) - Porto Alegre (RS), Brazil.
    Nail changes are present in about 50% of psoriasis patients and tend to be refractory to conventional treatments. Pulsed dye laser has emerged as an alternative therapy. Our aim is to evaluate the efficacy of pulsed dye laser in nail psoriasis and the impact of treatment on quality of life. Read More

    Effects of intramedullary nails composed of a new β-type Ti-Nb-Sn alloy with low Young's modulus on fracture healing in mouse tibiae.
    J Biomed Mater Res B Appl Biomater 2018 Jan 23. Epub 2018 Jan 23.
    Department of Orthopaedic Surgery, Tohoku University Graduate School of Medicine, Sendai, Miyagi, Japan.
    The influence of Young's moduli of materials on the fracture healing process remains unclear. This study aimed to assess the effects of intramedullary nails composed of materials with low Young's moduli on fracture repair. We previously developed a β-type Ti-Nb-Sn alloy with low Young's modulus close to that of human cortical bone. Read More

    The Jun/miR-22/HuR regulatory axis contributes to tumourigenesis in colorectal cancer.
    Mol Cancer 2018 Jan 19;17(1):11. Epub 2018 Jan 19.
    State Key Laboratory of Pharmaceutical Biotechnology, Collaborative Innovation Center of Chemistry for Life Sciences, Jiangsu Engineering Research Center for MicroRNA Biology and Biotechnology, NJU Advanced Institute for Life Sciences (NAILS), School of Life Sciences, Nanjing University, Nanjing, Jiangsu, 210046, China.
    Background: Colorectal cancer (CRC) is a severe health problem worldwide. Clarifying the mechanisms for the deregulation of oncogenes and tumour suppressors in CRC is vital for its diagnosis, treatment, prognosis and prevention. Hu antigen R (HuR), which is highly upregulated in CRC, functions as a pivotal oncogene to promote CRC progression. Read More

    Intramedullary Nailing of Metaphyseal Fractures of the Lower Extremity.
    Acta Chir Orthop Traumatol Cech 2017 ;84(5):330-340
    Department of Orthopedics and Traumatology, University Medical Center, Johannes Gutenberg-University, Mainz, Germany.
    Intramedullary nailing is a worldwide accepted technique for stabilization of fractures of long bones. Technique, instruments and implants primarily have been developed for the fixation of short (transverse and oblique) diaphyseal fractures. First generation nails were hollow and slotted, which gave them some elasticity. Read More

    [Tibio-Calcaneal Arthrodesis with Vertically Placed Tricortical Bone Graft after Traumatic Talar Extrusion - a Case Report].
    Acta Chir Orthop Traumatol Cech 2017 ;84(6):462-465
    Klinika úrazovej chirurgie Fakultná nemocnica Akad. Dérera, Slovenská zdravotnícka univerzita Bratislava.
    The aim of this publication is to present a case report of a 38-year-old patient with traumatic astragalectomy and resultant foot reconstruction surgery using a combination of talus compensation by vertically placed tricortical autograft and pantalar arthrodesis with a retrograde calcaneotibial nail (hindfoot nail). The advantage of this treatment is based on a solid, stable osteosynthesis, while maintaining the length of the limb. Key words: traumatic talar extrusion, tibiocalcaneal arthrodesis, hindfoot nail, bone graft, pantalar arthrodesis. Read More

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