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Ther Deliv 2019 Apr;10(4):211-214

Laboratory of Food, Drugs & Cosmetics (LTMAC), University of Brasília (UnB), 70910-900, Brasília, DF, Brazil.

Food Chem Toxicol 2019 May 20;127:163-172. Epub 2019 Mar 20.

Department of Environmental Health Sciences, Graduate School of Public Health, Seoul National University, Seoul, South Korea; Institute of Health and Environment, Seoul National University, Seoul, South Korea. Electronic address:

To estimate realistic exposure to a chemical, the aggregate exposure from multiple consumer products should be considered. A receptor-based aggregate exposure assessment was conducted according to individuals' exposure factors and simultaneous use patterns including co-use and non-use. A product-based aggregate exposure assessment was conducted by product usage rates of population and users' exposure factors. Read More

Expert Opin Drug Deliv 2019 Mar 1:1-18. Epub 2019 Mar 1.

a Department of Pharmaceutical Technology, Faculty of Pharmacy , University of Coimbra , Coimbra , Portugal.

Introduction: Nanotechnology is an increasingly widespread area of research for its various applications and advantages. Accordingly, nanotechnology has been the focus of investment in different areas of science, namely as a technological strategy for the development of cosmetics formulations. Nanosystems allow for a profit skin penetration and an effective release profile of ingredients, which contributes to superior technological and cosmetic effects. Read More

Clin Exp Dermatol 2019 Feb 21. Epub 2019 Feb 21.

Dermatology Department, Brighton and Sussex University Hospitals NHS Trust, Brighton, UK.

Nail cosmetics are used by millions worldwide and the variety of products available is expanding. They are relatively safe, but complications can occur, and patients experiencing complications may present to dermatologists. The physical processes can cause nail thinning and onycholysis, poor technique can promote infection, and consumers may develop allergic contact dermatitis. Read More

J Chromatogr A 2019 May 7;1593:9-16. Epub 2019 Feb 7.

Department of Analytical Chemistry, University of Valencia, 46100, Burjassot, Valencia, Spain. Electronic address:

This work describes a new analytical method useful for monitoring the human exposure to the endocrine-disrupting plasticizer triphenyl phosphate (TPP) via nail polish use. The method allows trace determination of this parent compound and its main metabolite, namely diphenyl phosphate (DPP), in urine samples of nail polish users. The method is based on a novel microextraction technique termed stir bar sorptive-dispersive microextraction (SBSDME) using a magnetic composite made of CoFeO magnetic nanoparticles embedded into a mixed-mode weak anion exchange polymer (Strata-X-AW), followed by liquid chromatography-tandem mass spectrometry (LC-MS/MS). Read More

J Expo Sci Environ Epidemiol 2019 Feb 6. Epub 2019 Feb 6.

Department of Environmental Health Sciences, University of Michigan School of Public Health, Ann Arbor, MI, USA.

Background: Phosphorous-containing flame-retardants (PFRs) are widely detected. They are used both as a flame retardant as well as plasticizer.

Methods: A subset of 230 women and 229 men were recruited from Massachusetts General Hospital fertility clinic between 2005 and 2015. Read More

J Cosmet Dermatol 2019 Jan 9. Epub 2019 Jan 9.

Faculty of Pharmacy, Department of Cosmetology and Aesthetic Dermatology, Medical University of Lodz, Lodz, Poland.

Background: Hybrid manicure is now a popular method of nail care and nail art, which is associated with its durability. Unfortunately, it has an adverse effect on pH, TOWL and overall nail plates condition and has not been investigated in detail so far.

Aims: The aim of this study was to compare the pH and TOWL of the hand nails after using different primers. Read More

An Bras Dermatol 2018 Nov/Dec;93(6):930-931

Interdisciplinary Field of Biomedical Sciences, Faculdade de Medicina, Universidade Federal do Rio Grande, Rio Grande (RS), Brazil.

Clin Rev Allergy Immunol 2019 Feb;56(1):119-128

Ohio University, 2359 E Main St., Columbus, OH, 43209, USA.

Allergic contact dermatitis (ACD) to cosmetics is extremely common-probably the most common reason patients present for patch testing. The diagnosis should initially be suspected based on the patient history and the distribution of the dermatitis. Once the diagnosis is suspected, empiric recommendations for low allergenicity products should be implemented until patch testing is performed. Read More

Pan Afr Med J 2018 6;30:103. Epub 2018 Jun 6.

Division of Dermatology, Groote Schuur Hospital, University of Cape Town, Observatory Cape Town, South Africa.

Angioedema is a type-1 hypersensitivity reaction that can be life threatening. It affects the skin airways and the gastrointestinal tract. Henna is a green powder used to dye skin and nails. Read More

Int J Cosmet Sci 2018 Dec 6;40(6):555-564. Epub 2018 Dec 6.

Coatings Research Institute, Eastern Michigan University, Ypsilanti, MI, USA.

Objective: Gel nail polishes represent an advanced class of nail polishes, with the ability to cure under ultraviolet (UV) radiation, and consequently demonstrate improved properties and greater durability compared to conventional nail polishes. Most gel nail polishes available today are based on petrochemical resources, making them unsustainable. Bio-based materials are excellent renewable resources, with high potential for meeting final-product performance, cost, and environmental needs. Read More

J Cardiothorac Surg 2018 Sep 11;13(1):93. Epub 2018 Sep 11.

Department of Cardiothoracic Surgery, Stanford University School of Medicine, 300 Pasteur Drive, Stanford, CA, 94305, USA.

Background: Yellow nail syndrome is a rare condition considered secondary to functional anomalies of lymphatic drainage. Yellow nail syndrome is diagnosed through the triad of intrathoracic findings (30% being pleural effusions), nail discoloration, and lymphedema, with any two features sufficient for diagnosis. We report the second case of post-operative yellow nail syndrome. Read More

PLoS One 2018 16;13(8):e0202608. Epub 2018 Aug 16.

Science and Engineering Faculty, Queensland University of Technology, Brisbane, Queensland, Australia.

Keratin is the structural protein in hair, nails, feathers and horns. Keratin is recalcitrant, highly disulfide bonded and is generally inaccessible to common proteases. Only certain types of proteases, called keratinases, are able to cleave the peptide bonds within the keratin structure. Read More

J Forensic Leg Med 2018 Aug 10;58:205-211. Epub 2018 Jul 10.

National Poisons Information Centre, Department of Pharmacology, All India Institute of Medical Sciences, New Delhi, 110029, India. Electronic address:

Extensive use of different chemicals in various fields and their easy availability has led to an increased incidence of accidental and intentional poisoning in developing countries including India. A diverse range of household products commonly used for domestic purposes comprise pesticides, household cleaners, thermometer mercury, antiseptics, kerosene, paint thinners etc. Any of these products, if misused or mishandled can cause poisoning. Read More

Dermatol Online J 2018 Apr 15;24(4). Epub 2018 Apr 15.

Department of Dermatology, University of California San Diego, La Jolla, California.

5-fluorouracil, a fluoropyrimidine antineoplastic drug, is used to topically treat actinic keratoses. Local skin reactions to the medication are common and anticipated. However, severe adverse events from topical 5-fluorouracil are rare and unexpected. Read More

Contact Dermatitis 2018 Jun 11. Epub 2018 Jun 11.

Department of Dermatology, University Hospitals KU Leuven, Leuven, Belgium.

Background: Acrylates and methacrylates are acrylic resin monomers that are known to induce skin sensitization as a result of their presence in different materials, such as nail cosmetics, dental materials, printing inks, and adhesives. Allergic contact dermatitis resulting from the use of modern wound dressings containing them has only rarely been reported.

Objectives: To describe 2 patients who developed allergic contact dermatitis caused by acrylic-based modern medical dressings and/or adhesives. Read More

Contact Dermatitis 2018 Sep 4;79(3):184-185. Epub 2018 May 4.

Skin and Cancer Foundation Inc, Carlton, Victoria, Australia.

J Expo Sci Environ Epidemiol 2018 05;28(3):242-250

Department of Dermatology, Dankook University Medical Center, Chungnam, Korea.

Despite daily exposure to chemicals in cosmetic products, there are few studies on the exposure levels to cosmetics particularly in Asians. We sought to investigate the usage pattern of cosmetics, including eye makeup products, fragrances, color makeups, and hair and nail care products, in Koreans. An online survey of 1,800 participants (908 males and 892 females, aged 15-59 years) from 5 Metropolitan cities (Seoul, Incheon, Daejeon, Daegu, and Busan) in Korea was conducted. Read More

Dermatol Online J 2018 Mar 15;24(3). Epub 2018 Mar 15.

Department of Dermatology and Cutaneous Biology, Thomas Jefferson University, Philadelphia, Pennsylvania.

Gel manicures have become a popular beauty trend in recent years. The specially formulated nail polish must undergo curing under light-based units. The majority of these curing lamps emit high-intensity ultraviolet A, which can cause skin damage and increase the risk for skin cancers. Read More

Eur Cell Mater 2018 03 22;35:178-194. Epub 2018 Mar 22.

United States Army Institute of Surgical Research, Extremity Trauma and Regenerative Medicine Task Area, Joint Base San Antonio-Fort Sam, Houston, Texas,

The use of internal intramedullary nails for long bone fracture fixation is a common practice among surgeons. Bacteria naturally attach to these devices, increasing the risk for wound infection, which can result in non- or malunion, additional surgical procedures and extended hospital stays. Intramedullary nail surface properties can be modified to reduce bacterial colonisation and potentially infectious complications. Read More

J Sep Sci 2018 May 12;41(10):2197-2206. Epub 2018 Mar 12.

Key Laboratory of Analytical Chemistry for Biology and Medicine (Ministry of Education), College of Chemistry and Molecular Science, Wuhan University, Wuhan, P. R. China.

We report the electrochemical fabrication of a poly(2,2-bithiophene-co-3-methylthiophene)-graphene composite coating and its application in the headspace solid-phase microextraction and gas chromatography determination of benzenes (i.e., bromobenzene, 4-bromotoluene, 2-nitrotoluene, 3-nitrotoluene and 1,2,4-trichlorobenzene). Read More

Contact Dermatitis 2018 Apr 12;78(4):261-265. Epub 2018 Jan 12.

Dermatology Department, Toledo Hospital Complex, 45071 Toledo, Spain.

Background: Allergic contact dermatitis (ACD) from (meth)acrylates caused by long lasting nail polish (also known as "permanent", "semi-permanent" or "gel nail polish") has been described both in occupational and non-occupational settings. Inexpensive kits for home use have been available for purchase in many stores or through the Internet.

Objective: To report on several further cases of consumers sensitised to these nail products. Read More

Exp Biol Med (Maywood) 2018 01 7;243(2):184-189. Epub 2018 Jan 7.

2 Division of Rheumatology Allergy and Clinical Immunology, University of California School of Medicine, Davis, CA 95616, USA.

Autoimmunity is a consequence of both genetic and environmental factors, occurring in genetically susceptible hosts with environmental triggers. While genome-wide association studies have revealed a number of susceptible genes contributing to etiology, the environmental triggers remain poorly understood. Primary biliary cholangitis, formally known as primary biliary cirrhosis, is considered a model autoimmune disease for which our group has extensively evaluated environmental factors involved in its etiology. Read More

J Dermatolog Treat 2018 Sep 10;29(6):633-636. Epub 2018 Jan 10.

d Medical Affairs , Sandoz Pharmaceuticals Inc , Princeton , NJ , USA.

Background: Topical antifungal treatments for onychomycosis are applied to clean, unpolished nails for 48 weeks or longer. Patients often wish to mask their infection with nail polish yet there is no evidence to suggest antifungal efficacy in the presence of nail polish.

Objective: To determine if tavaborole retains the ability to penetrate the nail plate and inhibit fungal growth in the presence of nail polish. Read More

Contact Dermatitis 2018 Apr 21;78(4):254-260. Epub 2017 Dec 21.

Finnish Institute of Occupational Health, 00250 Helsinki, Finland.

Background: Allergic contact dermatitis (ACD) caused by nail acrylates, also including methacrylates and cyanoacrylates here, is being increasingly reported.

Methods: A retrospective study in 11 European Environmental Contact Dermatitis Research Group (EECDRG) clinics collected information on cases of ACD caused by nail acrylates diagnosed by aimed testing between 2013 and 2015.

Results: Among 18 228 studied patients, 136 had ACD caused by nail acrylates (0. Read More

An Bras Dermatol 2017 May-Jun;92(3):421-422

College of Medical Sciences, Santa Casa de São Paulo - São Paulo (SP) Brazil.

The main allergen responsible for contact dermatitis to nail polish is tosylamide-formaldehyde resin. The so-called hypoallergenic nail polishes are suposedly free of agents that commonly trigger reactions. The commercially available products and their compositions were studied. Read More

Curr Pharm Des 2017 Nov 14. Epub 2017 Nov 14.

Laboratory of Nanosystems and Drug Delivery Devices (NanoSYS), School of Pharmacy, Universidade Federal de Goias, Rua 240, esq. com 5ª Avenida, Setor Leste Universitario, 74605-170, Goiania, GO. Brazil.

Background: Lipid nanoparticles have been extensively studied for drug delivery of antifungal drugs, especially for dermatophytosis treatments. They can accumulate in skin appendages and release drugs in a controlled manner and also increase skin moisture, due to the formation of an occlusive film. Since moisture heavily influences nail and skin permeability, these systems seem to pose great potential for antifungal drug delivery. Read More

Actas Dermosifiliogr 2018 Jul - Aug;109(6):508-514. Epub 2017 Nov 3.

Hospital General de Alicante, Alicante, España.

The first reported cases of allergic contact dermatitis from acrylates in manicure procedures in relation to the application of porcelain nails were published decades ago. The frequency of sensitization has increased due to the introduction of the so-called permanent nail polish containing photo-bonded acrylates, mainly involving the beauticians who apply them, and to a lesser extent, the consumers. The recent commercialized permanent polish kits for domestic use could trigger even higher degrees of sensitization. Read More

Am J Dermatopathol 2017 Nov;39(11):819-823

*Saint Louis University School of Medicine, St. Louis, MO; and†Dermatology Affiliates, Atlanta, GA.

Nail clipping specimens are commonly submitted for the microscopic evaluation of nail disease; however, there may be missing clinical history regarding nail polish or other adornments present on the nail at the time of specimen retrieval. For this study, 6 types of nail cosmetics were chosen and applied to the nail plate of a volunteer. After a period of at least 24 hours, the nail plates with adornments and a control nail plate were clipped and placed in formalin. Read More

Clin Exp Dermatol 2018 Jan 23;43(1):50-53. Epub 2017 Oct 23.

Department of Dermatology, Royal North Shore Hospital, St Leonards, NSW, Australia.

Allergic contact dermatitis (ACD) secondary to acrylates and methacrylates is a well- described occurrence, particularly in those who wear or handle gel nail varnish. Management involves avoidance of the identified allergen. The cause of chronic urticaria (CI) is often not identified, and CU is not known to be associated with acrylates or methacrylates. Read More

Skin Res Technol 2018 Feb 23;24(1):156-157. Epub 2017 Oct 23.

Department of Dermatology, University Hospital of Saint Etienne, Saint-Etienne, France.

Int J Cosmet Sci 2018 Feb 14;40(1):75-80. Epub 2017 Nov 14.

Institut d'Optique Graduate School Rhône-Alpes, Saint-Etienne, 42000, France.

Objective: The colour of a nail polish varies according to the nail on which it is applied. The objective of this study was to predict the colour of the nail polish on a given nail and to study how the colour varies depending on the nail polish thickness.

Methods: Six nail polishes were applied in one, two and three layers on the nails of one subject, thus forming eighteen samples. Read More

J Eur Acad Dermatol Venereol 2018 Jan 16;32(1):160-163. Epub 2017 Oct 16.

Department of Dermatology and Cutaneous Surgery, University of Miami Miller School of Medicine, Miami, FL, USA.

Background: Pterygium inversum unguis (PIU) is characterized by the abnormal adherence of the hyponychium to the ventral surface of the nail plate. It can be both unsightly and painful, resulting in morbidity for patients. Gel polish is a popular nail cosmetic that has been reported to cause several complications. Read More

CMAJ 2017 09;189(37):E1193

Doctor of Medicine Program (DeKoven), Schulich School of Medicine and Dentistry, London, Ont.; Division of Occupational Medicine (DeKoven, Holness), Department of Medicine, St. Michael's Hospital; Dalla Lana School of Public Health and Department of Medicine (Holness), University of Toronto; Centre for Urban Health Solutions (Holness), Li Ka Shing Knowledge Institute, St. Michael's Hospital, Toronto, Ont.

Skin Appendage Disord 2017 Aug 1;3(3):129-131. Epub 2017 Apr 1.

Royal Victoria Infirmary, Newcastle upon Tyne, UK.

Int J Pharm 2017 Oct 30;531(1):292-298. Epub 2017 Aug 30.

Laboratory of Nanosystems and Drug Delivery Devices (NanoSYS), School of Pharmacy, Universidade Federal de Goiás (UFG), Rua 240, Setor Leste Universitário, 74.605-170, Goiânia, GO, Brazil. Electronic address:

Voriconazole-loaded nanostructured lipid carriers (VOR-NLC) were developed and drug penetration evaluated in porcine hooves in vitro. Synergistic effect of urea (Ur), selected among other known chemical enhancers according to hoof hydration potential, was also evaluated. VOR-NLC presented a high encapsulation efficiency (74. Read More

J Sep Sci 2017 Nov 26;40(21):4168-4175. Epub 2017 Sep 26.

School of Science, Tokai University, Hiratsuka, Kanagawa, Japan.

We developed a reversed-phase high-performance liquid chromatography method with ultraviolet detection using on-line complexation with Cu(II) ion for analysis of five alcohols including diols and triol (methanol, ethanol, 1,2-propanediol, 1,3-propanediol, and glycerol). The Cu(II) ion concentration in the mobile phase had a great influence on the peak areas of these alcohols, but not on their retention times. Column temperature (25-40°C) and pH of the mobile phase did not affect the separation of analytes. Read More

Int J Occup Med Environ Health 2017 Oct 12;30(6):887-896. Epub 2017 Jul 12.

Nofer Institute of Occupational Medicine, Łódź, Poland (Department of Occupational Diseases and Environmental Health).

Objectives: Manicurists are exposed to various chemicals in nail and skin care products and may develop ocular, nasal, respiratory or skin adverse reactions to them. To investigate the occurrence of ocular, nasal, respiratory and skin problems among manicurists and to identify their causal factors, particularly allergic etiology and occupational origin.

Material And Methods: Manicurists employed in beauty salons in the central region of Poland were invited to fill in the questionnaire and undergo medical examination, skin prick tests with common aeroallergens, patch tests with European Baseline Series and (Meth)Acrylates Series-Nails and spirometry. Read More

Dermatitis 2017 Jul/Aug;28(4):231-240

From the *Icahn School of Medicine at Mount Sinai; and †Department of Dermatology, Icahn School of Medicine at Mount Sinai, New York.

Ingredients found in the nail cosmetic industry, including but not limited to methacrylate and acrylate monomers, formaldehyde, and toluene sulfonamide-formaldehyde resin, can incite allergic contact dermatitis. An eczematous outbreak presents on areas surrounding the nail plate and may spread through contact transfer of the allergen, commonly to the face and neck. Even components that were originally deemed nonsensitizing, such as the ubiquitous cyanoacrylate adhesive family, have been found to be allergenic. Read More

Hautarzt 2017 Nov;68(11):885-889

Klinik für Hautkrankheiten, Universitätsklinikum Jena, Erfurter Str. 35, 07743, Jena, Deutschland.

Background: Cosmetic products are subject to the European Cosmetics Regulation: They shall not harm human health when used under "normal or reasonably foreseeable conditions". Hazardous cosmetic products are reported by the EU Member States to the EU Commission and are listed in the database of the European Rapid Alert System RAPEX.

Material And Methods: The reports from Germany on dangerous cosmetic products from the years 2005-3/2017 in the European RAPEX database were systematically analyzed. Read More

IET Nanobiotechnol 2017 Mar;11(2):205-211

Department of Biotechnology, SGB Amravati University, Amravati 444 602, Maharashtra, India.

The authors report the biological synthesis of zinc oxide nanoparticles (ZnO-NPs) from the petals extract of L. (rose). Its efficacy was evaluated against two dermatophytes: namely: and which cause onychomycosis. Read More

Ned Tijdschr Geneeskd 2017 ;161:D918

Radboudumc, afd. Anesthesiologie, Pijn en Palliatieve zorg, Nijmegen.

- An increasing number of patients wear nail polish, artificial nails or have piercings.- There is uncertainty about the perioperative management of these items, especially when located outside the surgical area.- In the majority of hospitals, patients are urged to remove these items preoperatively, under the assumption that they might cause problems. Read More

J Cutan Med Surg 2017 Jul/Aug;21(4):340-344. Epub 2017 Mar 31.

2 Division of Occupational Medicine, Department of Medicine, St Michael's Hospital, Toronto, ON, Canada.

Background: Recently, many cases of acrylate-associated allergic contact dermatitis have appeared among nail salon workers. Common acrylate-containing products in nail salons include traditional nail polish, ultraviolet-cured shellac nail polish, ultraviolet-cured gel nails, and press-on acrylic nails.

Methods: Nail salon technicians seen in the occupational medicine clinic in 2015 and 2016 were identified, and their patch test results and clinical features were summarized. Read More

J Drugs Dermatol 2017 Mar;16(3):268-270

Subungual melanoma is a rare variant of acral lentiginous melanoma that often has a poor prognosis compared with other types of melanoma. The aim of the present study is to report a case of a patient with recurrence of subungual melanoma treated with imiquimod 5%, which presented a total regression of the lesion and no recurrence for 4 years.

J Drugs Dermatol. Read More