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    SLN- and NLC-encapsulating antifungal agents: skin drug delivery and their unexplored potential for treating onychomycosis.
    Curr Pharm Des 2017 Nov 14. Epub 2017 Nov 14.
    Laboratory of Nanosystems and Drug Delivery Devices (NanoSYS), School of Pharmacy, Universidade Federal de Goias, Rua 240, esq. com 5ª Avenida, Setor Leste Universitario, 74605-170, Goiania, GO. Brazil.
    Background: Lipid nanoparticles have been extensively studied for drug delivery of antifungal drugs, especially for dermatophytosis treatments. They can accumulate in skin appendages and release drugs in a controlled manner and also increase skin moisture, due to the formation of an occlusive film. Since moisture heavily influences nail and skin permeability, these systems seem to pose great potential for antifungal drug delivery. Read More

    Microscopy of Common Nail Cosmetics.
    Am J Dermatopathol 2017 Nov;39(11):819-823
    *Saint Louis University School of Medicine, St. Louis, MO; and†Dermatology Affiliates, Atlanta, GA.
    Nail clipping specimens are commonly submitted for the microscopic evaluation of nail disease; however, there may be missing clinical history regarding nail polish or other adornments present on the nail at the time of specimen retrieval. For this study, 6 types of nail cosmetics were chosen and applied to the nail plate of a volunteer. After a period of at least 24 hours, the nail plates with adornments and a control nail plate were clipped and placed in formalin. Read More

    Itching for nail fashion: chronic urticaria and chronic hand dermatitis secondary to acrylate and methacrylate allergy in gel nail varnish.
    Clin Exp Dermatol 2017 Oct 23. Epub 2017 Oct 23.
    Department of Dermatology, Royal North Shore Hospital, St Leonards, NSW, Australia.
    Allergic contact dermatitis (ACD) secondary to acrylates and methacrylates is a well- described occurrence, particularly in those who wear or handle gel nail varnish. Management involves avoidance of the identified allergen. The cause of chronic urticaria (CI) is often not identified, and CU is not known to be associated with acrylates or methacrylates. Read More

    Prediction of a nail polish colour applied on a nail.
    Int J Cosmet Sci 2017 Oct 23. Epub 2017 Oct 23.
    Institut d'Optique Graduate School Rhône-Alpes, Saint-Etienne, 42000, France.
    Objective: The colour of a nail polish varies according to the nail on which it is applied. The objective of this study was to predict the colour of the nail polish on a given nail and to study how the colour varies depending on the nail polish thickness.

    Methods: Six nail polishes were applied in one, two and three layers on the nails of one subject, thus forming eighteen samples. Read More

    Contact dermatitis caused by methacrylates in nail products.
    CMAJ 2017 09;189(37):E1193
    Doctor of Medicine Program (DeKoven), Schulich School of Medicine and Dentistry, London, Ont.; Division of Occupational Medicine (DeKoven, Holness), Department of Medicine, St. Michael's Hospital; Dalla Lana School of Public Health and Department of Medicine (Holness), University of Toronto; Centre for Urban Health Solutions (Holness), Li Ka Shing Knowledge Institute, St. Michael's Hospital, Toronto, Ont.

    Voriconazole-loaded nanostructured lipid carriers (NLC) for drug delivery in deeper regions of the nail plate.
    Int J Pharm 2017 Oct 30;531(1):292-298. Epub 2017 Aug 30.
    Laboratory of Nanosystems and Drug Delivery Devices (NanoSYS), School of Pharmacy, Universidade Federal de Goiás (UFG), Rua 240, Setor Leste Universitário, 74.605-170, Goiânia, GO, Brazil. Electronic address:
    Voriconazole-loaded nanostructured lipid carriers (VOR-NLC) were developed and drug penetration evaluated in porcine hooves in vitro. Synergistic effect of urea (Ur), selected among other known chemical enhancers according to hoof hydration potential, was also evaluated. VOR-NLC presented a high encapsulation efficiency (74. Read More

    Contact Sensitization to Allergens in Nail Cosmetics.
    Dermatitis 2017 Jul/Aug;28(4):231-240
    From the *Icahn School of Medicine at Mount Sinai; and †Department of Dermatology, Icahn School of Medicine at Mount Sinai, New York.
    Ingredients found in the nail cosmetic industry, including but not limited to methacrylate and acrylate monomers, formaldehyde, and toluene sulfonamide-formaldehyde resin, can incite allergic contact dermatitis. An eczematous outbreak presents on areas surrounding the nail plate and may spread through contact transfer of the allergen, commonly to the face and neck. Even components that were originally deemed nonsensitizing, such as the ubiquitous cyanoacrylate adhesive family, have been found to be allergenic. Read More

    [Dangerous cosmetic products in Germany : Analysis of the RAPEX database of the European Commission].
    Hautarzt 2017 Nov;68(11):885-889
    Klinik für Hautkrankheiten, Universitätsklinikum Jena, Erfurter Str. 35, 07743, Jena, Deutschland.
    Background: Cosmetic products are subject to the European Cosmetics Regulation: They shall not harm human health when used under "normal or reasonably foreseeable conditions". Hazardous cosmetic products are reported by the EU Member States to the EU Commission and are listed in the database of the European Rapid Alert System RAPEX.

    Material And Methods: The reports from Germany on dangerous cosmetic products from the years 2005-3/2017 in the European RAPEX database were systematically analyzed. Read More

    Contact Sensitization Due to Allergens in Nail Cosmetics: Identification, Treatment, and Prevention.
    Dermatitis 2017 Jun 13. Epub 2017 Jun 13.
    From the *Icahn School of Medicine at Mount Sinai; and †Department of Dermatology, Icahn School of Medicine at Mount Sinai, New York.
    Ingredients found in the nail cosmetic industry, including but not limited to methacrylate and acrylate monomers, formaldehyde, and toluene sulfonamide-formaldehyde resin, can incite allergic contact dermatitis. An eczematous outbreak presents on areas surrounding the nail plate and may spread through contact transfer of the allergen, commonly to the face and neck. Even components that were originally deemed nonsensitizing, such as the ubiquitous cyanoacrylate adhesive family, have been found to be allergenic. Read More

    Biosynthesis of zinc oxide nanoparticles by petals extract of Rosa indica L., its formulation as nail paint and evaluation of antifungal activity against fungi causing onychomycosis.
    IET Nanobiotechnol 2017 Mar;11(2):205-211
    Department of Biotechnology, SGB Amravati University, Amravati 444 602, Maharashtra, India.
    Aim: The authors report the biological synthesis of zinc oxide nanoparticles (ZnO-NPs) from the petals extract of Rosa indica L. (rose). Its efficacy was evaluated against two dermatophytes: namely: Trichophyton mentagrophytes and Microsporum canis which cause onychomycosis. Read More

    Subungual Melanoma In Situ Treated With Imiquimod 5% Cream After Conservative Surgery Recurrence.
    J Drugs Dermatol 2017 Mar;16(3):268-270

    Subungual melanoma is a rare variant of acral lentiginous melanoma that often has a poor prognosis compared with other types of melanoma. The aim of the present study is to report a case of a patient with recurrence of subungual melanoma treated with imiquimod 5%, which presented a total regression of the lesion and no recurrence for 4 years.

    J Drugs Dermatol. Read More


    The cosmetic and dermatological potential of keratin hydrolysate.
    J Cosmet Dermatol 2017 Feb 6. Epub 2017 Feb 6.
    Department of Polymer Engineering, Faculty of Technology, Tomas Bata University in Zlin, Zlin, the Czech Republic.
    Background: Although keratin hydrolysates have become established as standard components in hair and nail cosmetics, studies on the moisturizing effects of keratin hydrolysates do not appear among contemporary literature.

    Objectives: To test if adding keratin hydrolysate into an ointment base increases hydration of the skin and improves skin barrier function, or diminishes trans-epidermal water loss.

    Methods: Formulations were prepared containing 2%, 4%, and 6% keratin hydrolysates (based on weight of the ointment base). Read More

    [Effects of MMPs inhibitors on microleakage with wet bonding technique].
    Shanghai Kou Qiang Yi Xue 2016 Oct;25(5):548-552
    School of Stomatology, Jilin University. Changchun 130021, Jilin Province, China.
    Purpose: To observe the effects of matrix metalloproteinases(MMPs) inhibitors on microleakage with wet bonding technique.

    Methods: Twenty-seven premolars were randomly assigned to 3 groups. Class Ⅴ cavities were prepared in the neck of the teeth and treated with distilled water, 2% chlorhexidine (CHX) or 2% monocycline (MI) for 60 seconds. Read More

    Titanium Dioxide in Toothpaste Causing Yellow Nail Syndrome.
    Pediatrics 2017 Jan 7;139(1). Epub 2016 Dec 7.
    Department of Pediatrics, MacKay Children's Hospital, Taipei, Taiwan;
    Yellow nail syndrome (YNS) is an uncommon disorder, the classic triad of which consists of yellow nails, lymphedema, and respiratory symptoms. Few pediatric cases have been reported. We report a 9-year-old girl with yellowish nail discoloration for 1 year accompanied by respiratory symptoms, including chronic cough, recurrent pneumonia, bronchiectasis, and chronic sinusitis. Read More

    Improving tribological and anti-bacterial properties of titanium external fixation pins through surface ceramic conversion.
    J Mater Sci Mater Med 2017 Jan 24;28(1). Epub 2016 Nov 24.
    School of Metallurgy and Materials, University of Birmingham, Birmingham, B15 2TT, UK.
    In this study, an advanced ceramic conversion surface engineering technology has been applied for the first time to self-drilling Ti6Al4V external fixation pins to improve their performance in terms of biomechanical, bio-tribological and antibacterial properties. Systematic characterisation of the ceramic conversion treated Ti pins was carried out using Scanning electron microscope, X-ray diffraction, Glow-discharge optical emission spectroscopy, nano- and micro-indentation and scratching; the biomechanical and bio-tribological properties of the surface engineered Ti pins were evaluated by insertion into high density bone simulation material; and the antibacterial behaviour was assessed with Staphylococcus aureus NCTC 6571. The experimental results have demonstrated that the surfaces of Ti6Al4V external fixation pins were successfully converted into a TiO2 rutile layer (~2 μm in thickness) supported by an oxygen hardened case (~15 μm in thickness) with very good bonding due to the in-situ conversion nature. Read More

    UV-curable gels as topical nail medicines:In vivo residence, anti-fungal efficacy and influence of gel components on their properties.
    Int J Pharm 2016 Nov;514(1):244-254
    UCL School of Pharmacy, 29-39 Brunswick Square, London, WC1N 1AX, UK. Electronic address:
    UV-curable gels, used as nail cosmetics for their in vivo durability, were reported to be promising as topical nail medicines. Our first aim was thus to investigate whether such durability applies to drug-loaded formulations. This was found to be true. Read More

    A prospective randomised non-blinded comparison of conventional and Dorgan's crossed pins for paediatric supracondylar humeral fractures.
    Injury 2016 Nov 7;47(11):2479-2483. Epub 2016 Sep 7.
    Faculty of Kinesiology, University of Zagreb, Horvaćanski zavoj 15, 10000 Zagreb, Croatia, Croatia. Electronic address:
    Background: Closed reduction and percutaneous pinning are the preferred treatment of displaced supracondylar humeral fractures in children. The purpose of this study is to evaluate the non-standard Dorgan's method and compare its results with those of the standard percutaneous cross pinning method in treatment of unstable or irreducible Gartland type II and III supracondylar humeral fractures in children.

    Patients And Methods: This was a prospective evaluation of 138 consecutive patients with Gartland type II or III extension supracondylar humeral fractures referred to University Children's Hospital during a four-year period. Read More

    [Durability of protective effect of resin-based coating material on root surface].
    Beijing Da Xue Xue Bao Yi Xue Ban 2016 10;48(5):889-893
    Department of Cariology and Endodontology, Peking University School and Hospital of Stomatology & National Engineering Laboratory for Digital and Material Technology of Stomatology & Beijing Key Laboratory of Digital Stomatology, Beijing 100081, China.
    Objective: To compare the durability of resin-based root-surface coating material and all-in-one self-etching adhesive on root surface in vitro.

    Methods: Human extracted premolars or molars with intact roots were selected. The cementum was removed using a periodontal scaler to expose root dentin. Read More

    Chemical and physical strategies in onychomycosis topical treatment: A review.
    Med Mycol 2017 Jul;55(5):461-475
    Laboratory of Food, Drugs and Cosmetics (LTMAC). School of Health Sciences, University of Brasília. Campus Universitário Darcy Ribeiro, s/n, 70910-900, Brasília, DF, Brazil.
    Onychomycosis is a fungal infection of the fingernails or toenails caused by dermatophytes, nondermatophytes, moulds, and yeasts. This condition affects around 10-30% people worldwide, negatively influencing patients' quality of life, with severe outcomes in some cases. Since the nail unit acts as a barrier to exogenous substances, its physiological features hampers drug penetration, turning the onychomycosis treatment a challenge. Read More

    External lead contamination of women's nails by surma in Pakistan: Is the biomarker reliable?
    Environ Pollut 2016 Nov 21;218:723-727. Epub 2016 Aug 21.
    Department of Environmental and Preventive Medicine, Jichi Medical University, Shimotsuke, Tochigi, Japan. Electronic address:
    Adverse health effects of heavy metals are a public health concern, especially lead may cause negative health impacts to human fetal and infantile development. The lead concentrations in Pakistani pregnant women's nails, used as a biomarker, were measured to estimate the lead exposure. Thirteen nail samples out of 84 nails analyzed contained lead higher than the concentration (13. Read More

    Optical isopropanol biosensor using NADH-dependent secondary alcohol dehydrogenase (S-ADH).
    Talanta 2016 Oct 19;159:418-24. Epub 2016 Jun 19.
    Graduate school of Medical and Dental Sciences, Tokyo Medical and Dental University, 1-5-45 Yushima, Bunkyo-ku, Tokyo 113-8549, Japan; Department of Biomedical Devices and Instrumentation, Institute of Biomaterials and Bioengineering, Tokyo Medical and Dental University, 2-3-10 Kanda-Surugadai, Chiyoda-ku, Tokyo 101-0062, Japan. Electronic address:
    Isopropanol (IPA) is an important solvent used in industrial activity often found in hospitals as antiseptic alcohol rub. Also, IPA may have the potential to be a biomarker of diabetic ketoacidosis. In this study, an optical biosensor using NADH-dependent secondary alcohol dehydrogenase (S-ADH) for IPA measurement was constructed and evaluated. Read More

    Cosmetically Induced Disorders of the Nail with Update on Contemporary Nail Manicures.
    J Clin Aesthet Dermatol 2016 Apr 1;9(4):39-44. Epub 2016 Apr 1.
    Department of Dermatology and Cutaneous Surgery, University of Miami Leonard M. Miller School of Medicine, Miami, Florida.
    The nail carries a significant cosmetic impact and plays an integral role in the multi-billion dollar salon industry. This review focuses on nail disorders that are induced by nail cosmetics via procedures, equipment, or materials that are intended to beautify or adorn the nail. The authors give specific attention to clinical presentations that are common, novel, and underreported, but may be misdiagnosed easily by the competent dermatologist. Read More

    Acrylate and methacrylate contact allergy and allergic contact disease: a 13-year review.
    Contact Dermatitis 2016 Sep 11;75(3):157-64. Epub 2016 Jul 11.
    Birmingham Skin Centre, Sandwell and West Birmingham Hospitals NHS Trust, Birmingham, B18 7QH, UK.
    Background: (Meth)acrylates are important causes of contact allergy and allergic contact disease, such as dermatitis and stomatitis, with new and emerging sources resulting in changing clinical presentations.

    Objectives: To identify the (meth)acrylates that most commonly cause allergic contact disease, highlight their usefulness for screening, and examine their relationship with occupational and clinical data.

    Methods: A retrospective review of results from patch tests performed between July 2002 and September 2015, in one tertiary Cutaneous Allergy Unit, was performed

    Results: A series of 28 (meth)acrylates was applied to 475 patients. Read More

    Safety Assessment of Nitrocellulose and Collodion as Used in Cosmetics.
    Int J Toxicol 2016 Jul;35(1 Suppl):50S-9S
    Former Director, Cosmetic Ingredient Review, Cosmetic Ingredient Review, Washington, DC, USA.
    The Cosmetic Ingredient Review Expert Panel (the Panel) assessed the safety of nitrocellulose and collodion as used in cosmetics, concluding that these ingredients are safe in the present practices of use and concentration in cosmetic formulations. Both ingredients are used almost exclusively in nail product formulations. The maximum concentration of use of nitrocellulose in nail polish and enamels is 22%; for collodion, the maximum reported concentration of use in nail polish and enamel is 14%. Read More

    [Comparison of different nail polish in terms of photoprotective efficacy. Interest of their use as supportive care in patients with cancer].
    Bull Cancer 2016 Jul-Aug;103(7-8):612-21. Epub 2016 May 27.
    Université de Nantes, Nantes Atlantique universités, LPiC, MMS, EA2160, faculty of pharmacy, 9, rue Bias, 44000 Nantes, France. Electronic address:
    Many different chemotherapy drugs including cytotoxics and docetaxel in particular are responsible for side effects involving the nails. To prevent these negative effects, patients are advised to apply nail polish. The aim of this article is to study the photoprotective effect of various products applied in two layers. Read More

    Several cases of undesirable effects caused by methacrylate ultraviolet-curing nail polish for non-professional use.
    Contact Dermatitis 2016 Sep 27;75(3):151-6. Epub 2016 May 27.
    Department of Occupational and Environmental Dermatology, Skåne University Hospital, 205 02, Malmö, Sweden.
    Background: Ultraviolet (UV)-curing nail polishes based on acrylates or methacrylates are currently also available for non-professional use. The Swedish Medical Products Agency recently prohibited one brand of UV-curing polish, because several consumers reported undesirable effects after using it.

    Objectives: To investigate whether consumers with undesirable effects after using the UV-curing nail polish that was later prohibited were contact allergic to the polish and its individual ingredients. Read More

    Simultaneous determination of cosmetics ingredients in nail products by fast gas chromatography with tandem mass spectrometry.
    J Chromatogr A 2016 May 2;1446:134-40. Epub 2016 Apr 2.
    U.S. Food and Drug Administration, Office of Regulatory Science, CFSAN/HFS-717, 5100 Paint Branch Parkway, College Park, MD 20740-3835, USA.
    A rapid and sensitive gas chromatography with tandem mass spectrometry (GC-MS/MS) method has been developed and validated to quantitatively determine cosmetic ingredients, such as toluene, N-methylpyrrolidone, 2,4-dihydroxybenzophenone (benzophenone-1, BP-1), and diethylene glycol dimethacrylate, in nail products. In this procedure, test portions were extracted with acetone, followed by vortexing, sonication, centrifugation, and filtration. During the extraction procedure, BP-1 was derivatized making it amenable to GC-MS analysis, using N,O-​bis(trimethylsilyl)​trifluoroacetamide. Read More

    Changes in Cosmetics Use during Pregnancy and Risk Perception by Women.
    Int J Environ Res Public Health 2016 Mar 30;13(4):383. Epub 2016 Mar 30.
    EA 4681, PEPRADE (Périnatalité, Grossesse, Environnement, PRAtiques médicales et Developement), University of Auvergne, 28 Place Henri-Dunant BP 38, Clermont-Ferrand 63001, France.
    Cosmetic products contain various chemical substances that may be potential carcinogen and endocrine disruptors. Women's changes in cosmetics use during pregnancy and their risk perception of these products have not been extensively investigated. The main objective of this study was to describe the proportion of pregnant women changing cosmetics use and the proportion of non-pregnant women intending to do so if they became pregnant. Read More

    [Cosmetic nail products].
    Ann Dermatol Venereol 2016 May 14;143(5):389-96. Epub 2016 Mar 14.
    Département interhospitalier de dermatologie, CHU Brugmann-HUDERF, CHU Saint-Pierre, 322, rue Haute, 1000 Bruxelles, Belgique.
    Cosmetic embellishment of fingernails involves the use of substance that harden either after the evaporation of solvents (varnishes) or after polymerisation (artificial acrylic nails, gel tips, glue-on artificial nails). Pathological reactions to cosmetics usually occur at a remote site for varnishes, and, most commonly, in situ with polymerising substances. Unvarnished artificial nails do not affect pulse oximetry readings, and in theory, patients are not required to remove them. Read More

    Antimicrobial activity of Butyl acetate, Ethyl acetate and Isopropyl alcohol on undesirable microorganisms in cosmetic products.
    Int J Cosmet Sci 2016 Oct 9;38(5):476-80. Epub 2016 Mar 9.
    L'Oréal Research & Innovation, 188-200 rue Paul Hochart, 94550 Chevilly-Larue, France.
    Objective: The microbiological contamination risk of a cosmetic product has to be assessed by the manufacturer, according to the composition, to determine whether microbiological testing is required. Certain ingredients in cosmetic formulations help to create an environment hostile towards microbial growth. In this study, the influence on microbial survival of some solvents used in nail varnishes was evaluated. Read More

    Application of cosmetic nail varnish does not affect the antifungal efficacy of amorolfine 5% nail lacquer in the treatment of distal subungual toenail onychomycosis: results of a randomised active-controlled study and in vitro assays.
    Mycoses 2016 May 11;59(5):319-26. Epub 2016 Feb 11.
    Galderma R & D SNC, Sophia Antipolis, France.
    As onychomycosis is unsightly, this study clinically evaluated whether the antifungal efficacy of amorolfine 5% nail lacquer (NL) was affected by a masking, natural-coloured, cosmetic nail varnish applied 24 h later; in vitro investigations were also performed. Subjects with mild-to-moderate distal subungual toenail onychomycosis were randomised to receive amorolfine 5% NL once weekly with or without cosmetic nail varnish applied 24 h later. After 12-week treatment, antifungal activity of affected toenail clippings was assessed by measurement of zones of inhibition (ZOIs) on Trichophyton mentagrophytes seeded agar plates. Read More

    Evaluation of topical antifungal products in an in vitro onychomycosis model.
    Mycoses 2016 May 9;59(5):327-30. Epub 2016 Feb 9.
    Laboratory of Microbiology, Parasitology and Hygiene (LMPH), Faculty of Pharmaceutical, Biomedical and Veterinary Sciences, University of Antwerp, Antwerp, Belgium.
    Many topical commercial products are currently available for the treatment of onychomycosis. However, limited data are available concerning their antifungal activity. Using an in vitro onychomycosis model, the daily application of seven nail formulations was compared to the antifungal reference drug amorolfine (Loceryl(®) ) and evaluated for inhibitory activity against Trichophyton mentagrophytes using an agar diffusion test. Read More

    Effect of 10% fluoride on the remineralization of dentin in situ.
    J Appl Oral Sci 2015 Nov-Dec;23(6):562-70
    Department of Operative and Preventive Dentistry, University Witten/Herdecke, Witten, Germany.
    Objective The purpose of this randomized, cross-over, in situ study was to determine the remineralization of demineralized dentin specimens after the application of a 10% fluoride (F-) or a 1% chlorhexidine-1% thymol (CHX-thymol) varnish. Material and Methods Twelve individuals without current caries activity wore removable appliances in the lower jaw for a period of four weeks. Each appliance contained four human demineralized dentin specimens fixed on the buccal aspects. Read More

    Full thickness burns caused by cyanoacrylate nail glue: A case series.
    Burns 2016 Jun 6;42(4):e51-4. Epub 2016 Jan 6.
    The Burns Unit, Sheffield Children's Hospital, Sheffield, S10 2TH, UK. Electronic address:
    Artificial (acrylic) nails are popular cosmetic enhancements that provide the user with the appearance of manicured nails, do not chip or crack, and are generally considered very safe to apply. We report three cases where full thickness thermal burns were sustained from nail glue adhesive (cyanoacrylate) during the application of artificial nails. All three cases underwent surgical debridement and split skin graft reconstruction. Read More

    Comparative study of demineralized collagen degradation determined by hydroxyproline assay and microscopic depth measurement.
    J Dent 2016 Apr 7;47:94-7. Epub 2016 Jan 7.
    Cariology and Operative Dentistry, Department of Restorative Science, Graduate School, Tokyo Medical and Dental University, 1-5-45 Yushima, Bunkyo-ku, Tokyo 113-8549, Japan.
    Introduction: Quantification of collagen degradation is an important parameter to evaluate dentin caries progression or the efficacy of caries prevention aid. The aim of this study was to validate the simple light microscopic technique (LM) to evaluate collagen degradation by comparing with hydroxyproline assay technique (HPN).

    Materials And Methods: Bovine root dentin blocks were embedded in acrylic resin, polished and covered with nail varnish except a 1. Read More

    Risk assessment of allergen metals in cosmetic products.
    J Cosmet Sci 2015 Sep-Oct;66(5):313-23
    Cosmetics are one of the most common reasons for hospital referrals with allergic contact dermatitis. Because of the increased use of cosmetics within the population and an increase in allergy cases, monitoring of heavy metals, especially allergen metals, is crucial. The aim of this study was to investigate the concentration of allergen metals, nickel (Ni), cobalt (Co), and chromium (Cr), in the most commonly used cosmetic products including mascara, eyeliner, eye shadow, lipstick, and nail polish. Read More

    Impact of toothpaste on abrasion of sound and eroded enamel: An in vitro white light interferometer study.
    Am J Dent 2015 Oct;28(5):268-72
    Purpose: To evaluate the influence of brushing using toothpastes marketed under different categories on abrasion of sound and eroded enamel in vitro at nanometer scale using a white light interferometer (WLI).

    Methods: Enamel surface of resin-embedded bovine incisors were fine polished with diamond slurry and divided into testing area (approximately 2 mm x 4 mm) and reference area using a nail varnish. The enamel specimens were randomly assigned to 10 groups (n = 10 each); six of which were subjected to erosive challenge. Read More

    The Association Between Urinary Benzophenone Concentrations and Personal Care Product Use in Korean Adults.
    Arch Environ Contam Toxicol 2016 May 1;70(4):640-6. Epub 2015 Dec 1.
    Food Safety Risk Assessment Division, National Institute of Food and Drug Safety Evaluation, Osong, Chungcheongbuk-do, 361-709, Korea.
    Benzophenone (BP) derivatives are widely used in personal care products (PCPs) for protection from ultraviolet radiation. Because of their broad applications, BP derivatives have been found in various human bodily fluids. In the present study, we investigated the relationship between urinary concentrations of BP derivatives and PCP use in Korean adults. Read More

    Nail polish as a source of exposure to triphenyl phosphate.
    Environ Int 2016 Jan 18;86:45-51. Epub 2015 Oct 18.
    Nicholas School of the Environment, Duke University, Durham, NC, USA. Electronic address:
    Triphenyl phosphate (TPHP) is primarily used as either a flame retardant or plasticizer, and is listed as an ingredient in nail polishes. However, the concentration of TPHP in nail polish and the extent of human exposure following applications have not been previously studied. We measured TPHP in ten different nail polish samples purchased from department stores and pharmacies in 2013-2014. Read More

    Selected Disorders of Skin Appendages--Acne, Alopecia, Hyperhidrosis.
    Med Clin North Am 2015 Nov 4;99(6):1195-211. Epub 2015 Sep 4.
    Division of Dermatology, Department of Medicine, University of Washington, Box 354697, 4225 Roosevelt Way Northeast, 4th Floor, Seattle, WA 98105-6920, USA. Electronic address:
    This article reviewed some of the more common diseases of the skin appendages that are encountered in medicine: hyperhidrosis, acne, AA, FPHL, AGA, and TE. The pathophysiology behind the conditions and their treatments were discussed so that the clinician can make logical therapeutic choices for their affected patients. Read More

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