18,651 results match your criteria NDT PLUS [Journal]


Psychosocial consequences of living kidney donation: a prospective multicentre study on health-related quality of life, donor-recipient relationships and regret.

Nephrol Dial Transplant 2018 Dec 13. Epub 2018 Dec 13.

Institute of Psychology, Health, Medical and Neuropsychology Unit, Leiden University, Leiden, The Netherlands.

Background: Previous studies have indicated decreased health-related quality of life (HRQoL) shortly after kidney donation, returning to baseline in the longer term. However, a subgroup of donors experiences persistent HRQoL problems. To identify which HRQoL aspects are impacted most by the donation and to identify at-risk donors, more specific insight into psychosocial donation consequences is needed. Read More

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December 2018

Transcriptional modulation of the T helper 17/interleukin 17 axis ameliorates renal ischemia-reperfusion injury.

Nephrol Dial Transplant 2018 Dec 12. Epub 2018 Dec 12.

Kidney Research Institute, Seoul National University, Seoul, South Korea.

Background: Signal transducer and activator of transcription 3 (STAT3) is a latent transcription factor critical for T-cell function. Although inhibition of the Janus kinase 2 (JAK2)/STAT3 pathway has been reported to be protective against ischemia-reperfusion injury (IRI), the role of T cell-associated STAT3 in the pathogenesis of renal IRI has not been specifically defined.

Methods: We induced renal IRI in both mice with T cell-specific STAT3 knockout (Lck-Cre;STAT3flox/flox) and wild-type controls (C57BL/6) and assessed renal damage and inflammation at 48 h after IRI. Read More

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December 2018

MAGE genes in the kidney: identification of MAGED2 as upregulated during kidney injury and in stressed tubular cells.

Nephrol Dial Transplant 2018 Dec 11. Epub 2018 Dec 11.

Nephrology, IIS-Fundacion Jimenez Diaz-Universidad Autonoma de Madrid and Fundacion Renal Iñigo Alvarez de Toledo-IRSIN, Madrid, Spain.

Background: Mutations in Melanoma Antigen-encoding Gene D2 (MAGED2) promote tubular dysfunction, suggesting that MAGE proteins may play a role in kidney pathophysiology. We have characterized the expression and regulation of MAGE genes in normal kidneys and during kidney disease.

Methods: The expression of MAGE genes and their encoded proteins was explored by systems biology multi-omics (kidney transcriptomics and proteomics) in healthy adult murine kidneys and following induction of experimental acute kidney injury (AKI) by a folic acid overdose. Read More

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December 2018
3.577 Impact Factor

Educational level and risk of chronic kidney disease: longitudinal data from the PREVEND study.

Nephrol Dial Transplant 2018 Dec 12. Epub 2018 Dec 12.

Department of Health Sciences, University of Groningen, University Medical Center Groningen, Groningen, The Netherlands.

Background: The longitudinal association between low education and chronic kidney disease (CKD) and its underlying mechanisms is poorly characterized. We therefore examined the association of low education with incident CKD and change in kidney function, and explored potential mediators of this association.

Methods: We analysed data on 6078 participants from the community-based Prevention of Renal and Vascular End-stage Disease study. Read More

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December 2018

Hypertension in chronic kidney disease: Nephrology Dialysis Transplantation notable 2017 advances.

Nephrol Dial Transplant 2018 Dec 12. Epub 2018 Dec 12.

Department of Medicine, Indiana University School of Medicine and Richard L. Roudebush Veterans Administration Medical Center, Indianapolis, IN, USA.

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December 2018

Low magnesium diet aggravates phosphate-induced kidney injury.

Nephrol Dial Transplant 2018 Dec 7. Epub 2018 Dec 7.

Department of Nephrology, Osaka University Graduate School of Medicine, Osaka, Japan.

Background: Magnesium is known to protect against phosphate-induced tubular cell injuries in vitro. We investigated in vivo effects of magnesium on kidney injuries and phosphate metabolism in mice exposed to a high phosphate diet.

Methods: Heminephrectomized mice were maintained on a high phosphate/normal magnesium diet or a high phosphate/low magnesium diet for 6 weeks. Read More

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December 2018

Age-related renal function decline in Fabry disease patients on enzyme replacement therapy: a longitudinal cohort study.

Nephrol Dial Transplant 2018 Dec 10. Epub 2018 Dec 10.

Department of Medical Endocrinology, Copenhagen University Hospital, Rigshospitalet, Copenhagen, Denmark.

Background: Nephropathy is common in Fabry disease (FD). Prior studies of renal function during enzyme replacement therapy (ERT) have primarily used estimated glomerular filtration rate (eGFR). We studied the attrition of renal function in FD by measured GFR (mGFR) and urine protein excretion, and explored the influence of age. Read More

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December 2018

A non-invasive biomarker of type III collagen degradation reflects ischaemia reperfusion injury in rats.

Nephrol Dial Transplant 2018 Dec 7. Epub 2018 Dec 7.

Department of Clinical Medicine, Aarhus University, Aarhus, Denmark.

Background: Maintenance of kidney function in kidney allografts remains a challenge, as the allograft often progressively develops fibrosis after kidney transplantation. Fibrosis is caused by the accumulation of extracellular matrix proteins like type I and III collagen (COL I and III) that replace the functional tissue. We assessed the concentrations of a neo-epitope fragment of COL III generated by matrix metalloproteinase-9 cleavage (C3M) in two rat models resembling the ischaemic injury taking place following kidney transplantation. Read More

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December 2018

Erratum.

Nephrol Dial Transplant 2018 Dec 7. Epub 2018 Dec 7.

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December 2018

Inverse J-shaped relation between coronary arterial calcium density and mortality in advanced chronic kidney disease.

Nephrol Dial Transplant 2018 Dec 7. Epub 2018 Dec 7.

Division of Renal Medicine and Baxter Novum, Department of Clinical Science, Intervention and Technology, Karolinska Institutet, Campus Flemingsberg, Stockholm, Sweden.

Background: The coronary artery calcium (CAC) score from cardiac computed tomography (CT) is a composite of CAC volume and CAC density. In the general population, CAC volume is positively and CAC density inversely associated with cardiovascular disease (CVD) events, implying that decreased CAC density reflects atherosclerotic plaque instability. We analysed associations of CAC indices with mortality risk in patients with end-stage renal disease [chronic kidney disease Stage 5 (CKD5)]. Read More

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December 2018

Non-destructive testing of industrial equipment using muon radiography.

Philos Trans A Math Phys Eng Sci 2018 Dec 10;377(2137). Epub 2018 Dec 10.

Muon Tomography Systems S. L. Vasque country, Spain.

A new application of muon radiography (MR) is presented in the context of non-destructive testing of industrial equipment. The long-term operation of industrial facilities frequently involves the deterioration of critical components such as pipes and cauldrons due to corrosion and other processes. The precise determination of the inner state of this equipment is needed to ensure the integrity of the facility. Read More

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December 2018

Recent developments in endovascular interventions to sustain vascular access patency in haemodialysis patients.

Nephrol Dial Transplant 2018 Dec 5. Epub 2018 Dec 5.

Department of Nephrology, Patras University Hospital, Patras, Greece.

There is amassed evidence regarding the use of endovascular procedures for the treatment of vascular access stenosis and thrombosis. A review was conducted based on available randomized trials, cohort studies and retrospective analyses published after 2000 on endovascular treatment of dysfunctional and thrombosed vascular access, with an aim to illustrate the available device and procedural options. The use of paclitaxel-coated balloons, cutting balloons and covered stents is described in the field of vascular access stenosis. Read More

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December 2018
1 Read
3.577 Impact Factor

Emerging evidence of an effect of salt on innate and adaptive immunity.

Nephrol Dial Transplant 2018 Dec 5. Epub 2018 Dec 5.

Department of Renal Medicine, University College London (UCL), London, UK.

Salt intake as part of a western diet currently exceeds recommended limits, and the small amount found in the natural diet enjoyed by our Paleolithic ancestors. Excess salt is associated with the development of hypertension and cardiovascular disease, but other adverse effects of excess salt intake are beginning to be recognized, including the development of autoimmune and inflammatory disease. Over the last decade there has been an increasing body of evidence demonstrating that salt affects multiple components of both the innate and adaptive immune systems. Read More

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December 2018
3 Reads

Increased urinary miR-196a level predicts the progression of renal injury in patients with diabetic nephropathy.

Nephrol Dial Transplant 2018 Dec 5. Epub 2018 Dec 5.

National Clinical Research Center of Kidney Diseases, Jinling Hospital, Nanjing University School of Medicine, Nanjing, China.

Background: Recent data suggest that miR-196a is predominantly expressed in the kidney and plays an inhibitory role in the progress of renal interstitial fibrosis (IF). However, the predictive value of miR-196a in diabetic nephropathy (DN) remains unknown. We validated the role of urinary miR-196a in the progression of renal injury in a cohort of patients with type 2 diabetes mellitus. Read More

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December 2018
1 Read
3.577 Impact Factor

Glomerular filtration rate: when to measure and in which patients?

Nephrol Dial Transplant 2018 Dec 6. Epub 2018 Dec 6.

Department of Nephrology, Dialysis, Transplantation, University of Liège (CHU ULg), Liège, Belgium.

Of the glomerular, tubular and endocrine functions of the kidney, nephrologists have mostly focused their attention on the glomerular functions-albuminuria and glomerular filtration rate (GFR)-to grade the severity of chronic kidney disease (CKD). Although both albuminuria and GFR are associated with renal and cardiovascular morbidity and mortality, the utility of measured GFR (mGFR) has been questioned. GFR when measured adequately is the most precise measure of glomerular function and can be useful to individualize therapy among patients with CKD. Read More

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December 2018
4 Reads

Histological manifestations of rhabdomyolysis in the kidney.

Nephrol Dial Transplant 2018 Dec;33(12):2113-2114

Department of Internal Medicine, Leiden University Medical Center, Leiden, The Netherlands.

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December 2018

Positive Luminex and negative flow cytometry in kidney transplantation: a systematic review and meta-analysis.

Nephrol Dial Transplant 2018 Nov 30. Epub 2018 Nov 30.

Faculty of Health and Life Science, Institute of Learning and Teaching, University of Liverpool, Liverpool, UK.

The presence of pre-formed donor-specific antibodies (DSAs) in kidney transplantation is associated with worse overall outcomes compared with DSA-negative transplantation. A positive complement-dependant cytotoxic crossmatch presents a high immunological risk, while a negative flow cytometry crossmatch is at the lower end of the risk spectrum. Yet, the presence of low-level DSA detected by Luminex alone, that is, positive Luminex and negative flow (PLNF) cytometry crossmatch lacks robust scientific exploration. Read More

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November 2018
2 Reads

Accelerated podocyte detachment early after kidney transplantation is related to long-term allograft loss of function.

Nephrol Dial Transplant 2018 Nov 29. Epub 2018 Nov 29.

Department of Internal Medicine, University of Michigan, Ann Arbor, MI, USA.

Background: Kidney allograft half-life has not improved despite excellent short-term survival. Recent long-term surveillance biopsy studies identify accumulating glomerulosclerosis (GS) to be associated with late allograft loss. While podocyte depletion is well known to drive proteinuria and GS in animal models and human glomerular diseases, its role in renal allograft loss of function is generally not recognized. Read More

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November 2018
1 Read

Mortality and morbidity following exercise-based renal rehabilitation in patients with chronic kidney disease: the effect of programme completion and change in exercise capacity.

Nephrol Dial Transplant 2018 Nov 30. Epub 2018 Nov 30.

Renal Sciences, Department of Transplantation, Immunology and Mucosal Biology, King's College London University, London, UK.

Background: Twelve weeks of renal rehabilitation (RR) have been shown to improve exercise capacity in patients with chronic kidney disease (CKD); however, survival following RR has not been examined.

Methods: This study included a retrospective longitudinal analysis of clinical service outcomes. Programme completion and improvement in exercise capacity, characterised as change in incremental shuttle walk test (ISWT), were analysed with Kaplan-Meier survival analyses to predict risk of a combined event including death, cerebrovascular accident, myocardial infarction and hospitalisation for heart failure in a cohort of patients with CKD. Read More

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November 2018
1 Read

The role of dialysis in the pathogenesis and treatment of dementia.

Authors:
Dearbhla M Kelly

Nephrol Dial Transplant 2018 Nov 27. Epub 2018 Nov 27.

Center for Prevention of Stroke and Dementia, Nuffield Department of Clinical Neurosciences, John Radcliffe Hospital, University of Oxford, Oxford, UK.

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November 2018

Endothelial cells exposed to phosphate and indoxyl sulphate promote vascular calcification through interleukin-8 secretion.

Nephrol Dial Transplant 2018 Nov 27. Epub 2018 Nov 27.

MP3CV Laboratory, EA7517, FHU REMOD-VHF, University of Picardie Jules Verne, Amiens, France.

Background: Vascular calcification (VC) is amplified during chronic kidney disease, partly due to uraemic toxins such as inorganic phosphate (Pi) and indoxyl sulphate (IS) that trigger osteogenic differentiation of vascular smooth muscle cells (VSMCs). These toxins also alter endothelial cell (EC) functions but whether this contributes to VC is unknown. Here, we hypothesized that ECs exposed to Pi and IS promote VSMC calcification. Read More

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November 2018
1 Read

Strategies to address clinician hesitancy toward conservative care.

Nephrol Dial Transplant 2018 Nov 23. Epub 2018 Nov 23.

Renal Electrolyte Division, Section of Palliative Care and Medical Ethics, University of Pittsburgh School of Medicine, Pittsburgh, PA, USA.

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November 2018

Towards a personalized treatment for IgA nephropathy considering pathology and pathogenesis.

Authors:
Rosanna Coppo

Nephrol Dial Transplant 2018 Nov 26. Epub 2018 Nov 26.

Fondazione Ricerca Molinette, Regina Margherita Hospital, Turin, Italy.

The search of personalized treatment for a subject with immunoglobulin A nephropathy (IgAN) is appealing since the individual long-term outcome is highly variable in spite of common mild clinical signs such as microscopic haematuria, moderate proteinuria and slightly reduced glomerular filtration rate (GFR). The only risk factor considered by the Kidney Disease: Improving Global Outcomes (KDIGO) guidelines to target corticosteroid/immunosuppressive treatment in IgAN is proteinuria persistently >1 g/day despite 3-6 months of optimized supportive care. However, proteinuria in IgAN may result not only from active lesions but also from sclerotic glomerular lesions with hyperfiltration and tubular damage. Read More

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November 2018
4 Reads

Reducing calcineurin inhibitor first for treating BK polyomavirus replication after kidney transplantation: long-term outcomes.

Nephrol Dial Transplant 2018 Nov 23. Epub 2018 Nov 23.

Clinic for Transplantation Immunology and Nephrology, University Hospital Basel, Basel, Switzerland.

Background: Reducing immunosuppression is the mainstay of treating BK polyomavirus (BKPyV) viraemia after kidney transplantation, but the best approach, efficacy and impact are undefined. We established a standard operating procedure (SOP) treating BKPyV viraemia based on first reducing calcineurin inhibitor ('CNI first'). The aim of this study was to investigate long-term outcomes in 644 consecutive transplantations using this SOP. Read More

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November 2018
3 Reads

Sex-specific analysis of haemodialysis prevalence, practices and mortality over time: the Austrian Dialysis Registry from 1965 to 2014.

Nephrol Dial Transplant 2018 Nov 21. Epub 2018 Nov 21.

Clinical Division of Nephrology and Dialysis, Department of Internal Medicine III, Medical University of Vienna, Vienna, Austria.

Background: Despite a higher prevalence of chronic kidney disease among women, more men than women start renal replacement therapy (RRT). We hypothesized that gender differences in health care access exist and therefore aimed at determining whether characteristics and outcomes of haemodialysis patients over time differ by sex.

Methods: We studied all 28 323 adults who began haemodialysis during 1965-2014 in the Austrian Dialysis Registry, analysing trends in patient characteristics by sex and decade with mortality (via Cox regression), which was compared with the mortality of the Austrian general population. Read More

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November 2018
3 Reads

Drugs linked to plasma homoarginine in chronic kidney disease patients-a cross-sectional analysis of the German Chronic Kidney Disease cohort.

Nephrol Dial Transplant 2018 Nov 23. Epub 2018 Nov 23.

Department of Nephrology and Hypertension, Friedrich-Alexander-Universität Erlangen-Nürnberg, Erlangen, Germany.

Background: Elevated plasma concentrations of symmetric and asymmetric dimethylarginine (SDMA and ADMA, respectively) and a lower plasma concentration of the structurally related homoarginine are commonly observed in patients with chronic kidney disease (CKD) and independently predict total mortality as well as progression of renal disease. We aimed to identify drugs that may alter this adverse metabolite pattern in a favourable fashion.

Methods: Plasma ADMA, SDMA, homoarginine and l-arginine were determined by liquid chromatography-tandem mass spectrometry in 4756 CKD patients ages 18-74 years with an estimated glomerular filtration rate (eGFR) of 30-60 mL/min/1. Read More

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November 2018

Long-term blood pressure monitoring by office and 24-h ambulatory blood pressure in renal transplant patients: a longitudinal study.

Nephrol Dial Transplant 2018 Nov 23. Epub 2018 Nov 23.

CNR-IFC (National Research Centre, Institute of Clinical Physiology), Clinical Epidemiology of Renal Diseases and Hypertension Unit, Reggio Calabria, Italy.

Background: Renal transplant patients have a high prevalence of nocturnal hypertension, and hypertension misclassification by office blood pressure (BP) is quite common in these patients. The potential impact of hypertension misclassification by office BP on hypertension management in this population has never been analysed.

Methods: We performed a longitudinal study in a cohort of 260 clinically stable renal transplant patients. Read More

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November 2018

Modulation of the microbiota by oral antibiotics treats immunoglobulin A nephropathy in humanized mice.

Nephrol Dial Transplant 2018 Nov 20. Epub 2018 Nov 20.

INSERM 1149, Center for Research on Inflammation (CRI), Paris, France.

Background: Immunoglobulin A nephropathy (IgAN) is the most common primary glomerulonephritis worldwide. IgA is mainly produced by the gut-associated lymphoid tissue (GALT). Both experimental and clinical data suggest a role of the gut microbiota in this disease. Read More

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November 2018
5 Reads

The European Certificate in Nephrology: what is involved and how to prepare.

Nephrol Dial Transplant 2018 Nov 16. Epub 2018 Nov 16.

University Hospital Southampton NHS Trust.

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November 2018
1 Read

Repeat renal biopsy improves the Oxford classification-based prediction of immunoglobulin A nephropathy outcome.

Nephrol Dial Transplant 2018 Nov 15. Epub 2018 Nov 15.

Department of Nephrology, Dialysis and Renal Transplantation, HOPITAL NORD, CHU Saint-Etienne, France.

Background: The prognosis of IgA nephropathy (IgAN) is very heterogeneous. Predicting the nature and the rate of the disease progression is crucial for refining patient treatment. The aim of this study was to evaluate the prognostic impact of an Oxford classification-based repeat kidney tissue evaluation to predict end-stage renal disease (ESRD). Read More

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November 2018
5 Reads

An update of the ERA-EDTA Registry primary renal disease coding system: what's new?

Nephrol Dial Transplant 2018 Nov 15. Epub 2018 Nov 15.

Newcastle Upon Tyne Hospitals NHS Foundation Trust, Newcastle Upon Tyne, UK.

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November 2018
3 Reads

The dominant prognostic value of physical functioning among quality of life domains in end-stage kidney disease.

Nephrol Dial Transplant 2018 Nov 15. Epub 2018 Nov 15.

CNR-IFC, Clinical Epidemiology and Physiopathology of Renal Diseases and Hypertension, Reggio Calabria, Italy.

Background: The prognostic relevance of health-related quality of life (HRQoL) has been scarcely studied in the dialysis population and the prognostic power for mortality of the HRQoL domains is unknown.

Methods: We tested the prognostic value for mortality of the HRQoL domains included in the 36-item Short Form Health Survey (SF-36) by Cox's regression analysis and by state-of-the-art prognostic techniques {explained variation in mortality [R2], calibration, discrimination [Harrell's C], risk reclassification [Net Reclassification Index (NRI)], Integrated Discrimination Index [IDI]} in a cohort of 951 patients on chronic haemodialysis.

Results: In multivariable Cox models, all but two domains (role limitation due to physical health and due to emotional problems) were independently related with mortality. Read More

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November 2018
5 Reads

Performance Analysis of NDT-based Graph SLAM for Autonomous Vehicle in Diverse Typical Driving Scenarios of Hong Kong.

Sensors (Basel) 2018 Nov 14;18(11). Epub 2018 Nov 14.

Interdisciplinary Division of Aeronautical and Aviation Engineering, The Hong Kong Polytechnic University, Hong Kong, China.

Robust and lane-level positioning is essential for autonomous vehicles. As an irreplaceable sensor, Light detection and ranging (LiDAR) can provide continuous and high-frequency pose estimation by means of mapping, on condition that enough environment features are available. The error of mapping can accumulate over time. Read More

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November 2018
8 Reads

2018 landmark papers in transplantation published in NDT: clinical research highlights in the area of kidney transplantation.

Authors:
Rainer Oberbauer

Nephrol Dial Transplant 2018 Nov 13. Epub 2018 Nov 13.

Medical University of Vienna, Department of Nephrology, Vienna, Austria.

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November 2018
1 Read

Is there long-term value of pathology scoring in immunoglobulin A nephropathy? A validation study of the Oxford Classification for IgA Nephropathy (VALIGA) update.

Nephrol Dial Transplant 2018 Nov 9. Epub 2018 Nov 9.

CNR-IFC, Epidemiology, Reggio Calabria, Italy.

Background: It is unknown whether renal pathology lesions in immunoglobulin A nephropathy (IgAN) correlate with renal outcomes over decades of follow-up.

Methods: In 1130 patients of the original Validation Study of the Oxford Classification for IgA Nephropathy (VALIGA) cohort, we studied the relationship between the MEST score (mesangial hypercellularity, M; endocapillary hypercellularity, E; segmental glomerulosclerosis, S; tubular atrophy/interstitial fibrosis, T), crescents (C) and other histological lesions with both a combined renal endpoint [50% estimated glomerular filtration rate (eGFR) loss or kidney failure] and the rate of eGFR decline over a follow-up period extending to 35 years [median 7 years (interquartile range 4.1-10. Read More

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November 2018
4 Reads
3.577 Impact Factor

Potassium: poison or panacea in chronic kidney disease?

Nephrol Dial Transplant 2018 Nov 12. Epub 2018 Nov 12.

Department of Internal Medicine, Division of Nephrology, University of Groningen, University Medical Center Groningen, Groningen, The Netherlands.

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November 2018
6 Reads

Too much nephrology? The CKD epidemic is real and concerning. A PRO view.

Authors:
Ron T Gansevoort

Nephrol Dial Transplant 2018 Nov 12. Epub 2018 Nov 12.

Department of Nephrology, University Medical Center Groningen, University of Groningen, Groningen, The Netherlands.

After decades of Babylonian confusion, we finally have a clear, uniform and widely accepted definition of chronic kidney disease (CKD). Based on evidence, and in accordance with other diseases, this definition is independent of age. This has made it possible to study the relevance and prevalence of CKD. Read More

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November 2018
2 Reads

Too much nephrology? The CKD epidemic is real and concerning. A CON view.

Authors:
Pierre Delanaye

Nephrol Dial Transplant 2018 Nov 12. Epub 2018 Nov 12.

Department of Nephrology-Dialysis-Transplantation, University of Liège (ULg CHU), CHU Sart Tilman, Liège, Belgium.

The prevalence of chronic kidney disease (CKD) clearly depends on its definition, and the definition used most often is the one proposed by the Kidney Disease: Improving Global Outcomes guidelines in 2012: 'CKD is defined as abnormalities of kidney structure or function, present for >3 months, with implications for health.' Abnormality of kidney function is a glomerular filtration rate (GFR) <60 mL/min/1.73 m2, and the most frequently used marker of kidney damage is the presence of albuminuria [albumin excretion rate >30 mg/24 h or albumin/creatinine ratio (ACR) >30 mg/g (or 3 mg/mmol)]. Read More

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November 2018
2 Reads

Reduced oxygenation but not fibrosis defined by functional magnetic resonance imaging predicts the long-term progression of chronic kidney disease.

Nephrol Dial Transplant 2018 Nov 12. Epub 2018 Nov 12.

Department of Nephrology, Faculty of Medicine, Saitama Medical University, Saitama, Japan.

Background: Although chronic hypoxia and fibrosis may be a key to the progression of chronic kidney disease (CKD), a noninvasive means of measuring these variables is not yet available. Here, using blood oxygen level-dependent (BOLD) and diffusion-weighted (DW) magnetic resonance imaging (MRI), we assessed changes in renal tissue oxygenation and fibrosis, respectively, and evaluated their correlation with prognosis for renal function.

Methods: The study was conducted under a single-center, longitudinal, retrospective observational design. Read More

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November 2018

A combined linear and nonlinear ultrasound time-domain approach for impact damage detection in composite structures using a constructive nonlinear array technique.

Ultrasonics 2018 Oct 25;93:43-62. Epub 2018 Oct 25.

University of Bath, Materials Research, Department of Mechanical Engineering, Claverton Down, Bath, UK. Electronic address:

Discovery and evaluation concerns of barely visible impact damage in composite materials is a well-known issue in industries using these materials. This work proposes a frequency sweep method where damage assessment is conducted with respect to the time domain. Firstly, a combined linear and nonlinear ultrasound imaging technique is proposed, which focuses on the excitation of damage/defect regions using a frequency sweep methodology from multiple transducer locations. Read More

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October 2018
1 Read

Computerized Ultrasonic Imaging Inspection: From Shallow to Deep Learning.

Sensors (Basel) 2018 Nov 7;18(11). Epub 2018 Nov 7.

National Metrology Institute of Japan (NMIJ), National Institute of Advanced Industrial Science and Technology (AIST), Tsukuba Central 2, Tsukuba 305-8568, Japan.

For many decades, ultrasonic imaging inspection has been adopted as a principal method to detect multiple defects, e.g., void and corrosion. Read More

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November 2018
4 Reads

Alterations of peritoneal transport characteristics in dialysis patients with ultrafiltration failure: tissue and capillary components.

Nephrol Dial Transplant 2018 Nov 6. Epub 2018 Nov 6.

Nalecz Institute of Biocybernetics and Biomedical Engineering, Polish Academy of Sciences, Warsaw, Poland.

Background: Ultrafiltration failure (UFF) in peritoneal dialysis (PD) patients is due to altered peritoneal transport properties leading to reduced capacity to remove excess water. Here, with the aim to establish the role of local alterations of the two major transport barriers, peritoneal tissue and capillary wall, we investigate changes in overall peritoneal transport characteristics in UFF patients in relation to corresponding local alterations of peritoneal tissue and capillary wall transport properties.

Methods: Six-hour dwell studies using 3. Read More

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November 2018
6 Reads

Impaired urinary concentration ability is a sensitive predictor of renal disease progression in Joubert syndrome.

Nephrol Dial Transplant 2018 Nov 6. Epub 2018 Nov 6.

Department of Nephrology and Urology, Unit of Nephrology and Dialysis, IRCCS Bambino Gesù Children's Hospital, Rome, Italy.

Background: Joubert syndrome (JS) is an inherited ciliopathy characterized by a complex midbrain-hindbrain malformation and multiorgan involvement. Renal disease, mainly juvenile nephronophthisis (NPH), was reported in 25-30% patients although only ∼18% had a confirmed diagnosis of chronic kidney disease (CKD). NPH often remains asymptomatic for many years, resulting in delayed diagnosis. Read More

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November 2018
6 Reads
3.580 Impact Factor

Sildenafil for the treatment of preeclampsia, an update: should we still be enthusiastic?

Nephrol Dial Transplant 2018 Nov 6. Epub 2018 Nov 6.

Department of Nephrology and Kidney Transplantation, Hôpital Tenon, Assistance publique - Hôpitaux de Paris, Paris, France.

Preeclampsia is a hypertensive disorder of pregnancy and the clinical manifestation of severe endothelial dysfunction associated with maternal and foetal morbidity and mortality. The primum movens of the disease is the defect of invasion of the uterine arteries by foetal syncytiotrophoblasts, which causes a maladaptive placental response to chronic hypoxia and the secretion of the soluble form of type 1 vascular growth endothelial factor receptor, also called soluble fms-like tyrosine kinase 1 (sFlt-1), the major player in the pathophysiology of the disease. Among its different effects, sFlt-1 induces abnormal sensitivity of the maternal vessels to the vasoconstrictor angiotensin II. Read More

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November 2018
4 Reads

Comparison of high glomerular filtration rate thresholds for identifying hyperfiltration.

Nephrol Dial Transplant 2018 Nov 6. Epub 2018 Nov 6.

Division of Nephrology and Hypertension, Mayo Clinic, Rochester, MN, USA.

Background: High glomerular filtration rate (GFR) is often used as a surrogate for single-nephron hyperfiltration. Our objective was to determine the definition for high GFR that best reflects clinical and structural characteristics of hyperfiltration.

Methods: We studied living kidney donors at the Mayo Clinic and Cleveland Clinic. Read More

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November 2018
10 Reads

Not all hyperphosphataemias should be treated.

Nephrol Dial Transplant 2018 Nov 6. Epub 2018 Nov 6.

Department of Rheumatology, INSERM U1132 & USPC Paris-Diderot, Hôpital Lariboisière, Paris, France.

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November 2018

Characteristics of SH0-wave Converted to T(0, 1)-wave Based on a T-shaped Plate Wrapped Around a Pipe.

IEEE Trans Ultrason Ferroelectr Freq Control 2018 Nov 2. Epub 2018 Nov 2.

Ultrasonic guided waves are widely used in industrial NDT for pipes and plates, where pipe-waves and plate-waves exhibit similar behaviors for some specific modes. This paper investigates the characteristics of an SH0 mode plate-wave converted to a T(0, 1) mode pipe-wave based on their similar dispersion and wave structure properties. First, the analytical solution is initially proposed to analyze the characteristics of the SH0-wave propagation in a model of arrayed plates coupled to a pipe. Read More

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November 2018
1.512 Impact Factor

Derivation and validation of a prognostic model to predict mortality in patients with advanced chronic kidney disease.

Nephrol Dial Transplant 2018 Nov 5. Epub 2018 Nov 5.

Division of Nephrology, Baystate Medical Center, University of Massachusetts Medical School-Baystate, Springfield, MA, USA.

Background: Guiding patients with advanced chronic kidney disease (CKD) through advance care planning about future treatment obliges an assessment of prognosis. A patient-specific integrated model to predict mortality could inform shared decision-making for patients with CKD.

Methods: Patients with Stages 4 and 5 CKD from Massachusetts (749) and West Virginia (437) were prospectively evaluated for clinical parameters, functional status [Karnofsky Performance Score (KPS)] and their provider's response to the Surprise Question (SQ). Read More

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November 2018
1 Read

Combined Damage Index to Detect Plastic Deformation in Metals Using Acoustic Emission and Nonlinear Ultrasonics.

Materials (Basel) 2018 Nov 1;11(11). Epub 2018 Nov 1.

Civil and Materials Engineering Department, University of Illinois at Chicago, Chicago, IL 60607, USA.

Understanding the amount of degradation using nondestructive evaluation (NDE) methods provides an effective way of determining the fitness to service and the residual life of structural components. Due to uncertainties introduced by the single NDE method, a combined damage index using multi-sensor data increases the reliability of damage assessment. In this paper, the outputs of three NDE methods including acoustic emission (AE), linear ultrasonics (LUT), and nonlinear ultrasonics (NLUT) are merged to identify the amount of plastic deformation in aluminum 1100. Read More

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November 2018
1 Read