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    Pain therapeutics from cone snail venoms: From Ziconotide to novel non-opioid pathways.
    J Proteomics 2018 May 16. Epub 2018 May 16.
    Departments of Biology, University of Utah, Salt Lake City, UT, United States.
    There have been numerous attempts to develop non-opioid drugs for severe pain, but the vast majority of these efforts have failed. A notable exception is Ziconotide (Prialt®), approved by the FDA in 2004. In this review, we summarize the present status of Ziconotide as a therapeutic drug and introduce a wider framework: the potential of venom peptides from cone snails as a resource providing a continuous pipeline for the discovery of non-opioid pain therapeutics. Read More

    Therapeutic Approach to Hypertension Urgencies and Emergencies in the Emergency Room.
    High Blood Press Cardiovasc Prev 2018 May 18. Epub 2018 May 18.
    School of Medicine and Surgery, University of Milano-Bicocca, Milan, Italy.
    Hypertensive urgencies-emergencies are important and common events. They are defined as a severe elevation in BP, higher than 180/120 mmHg, associated or not with the evidence of new or worsening organ damage for emergencies and urgencies respectively. Anamnestic information, physical examination and instrumental evaluation determine the following management that could need oral (for urgencies) or intravenous (for emergencies) anti-hypertensives drugs. Read More

    Naloxone laws facilitate the establishment of overdose education and naloxone distribution programs in the United States.
    Drug Alcohol Depend 2018 May 12. Epub 2018 May 12.
    RTI-International, 351 California St, Suite 500, San Francisco, CA, 94104, USA. Electronic address:
    Background: The opioid overdose crisis in the United States continues to worsen. Opioid overdose mortality is entirely preventable with timely administration of naloxone. Since 2001, many states have passed laws to create an enabling environment for the implementation of overdose education and naloxone distribution (OEND) programs. Read More

    Proteomic profiling of skeletal and cardiac muscle in cancer cachexia: alterations in sarcomeric and mitochondrial protein expression.
    Oncotarget 2018 Apr 24;9(31):22001-22022. Epub 2018 Apr 24.
    Mechanisms of Disease and Translational Research, School of Medical Sciences, Faculty of Medicine, UNSW Sydney, New South Wales, Australia.
    Background: Cancer cachexia is observed in more than 50% of advanced cancer patients, and impairs quality of life and prognosis. A variety of pathways are likely to be dysregulated. Hence, a broad-spectrum understanding of the disease process is best achieved by a discovery based approach such as proteomics. Read More

    A shift toward personalized healthcare: does the Affordable Care Act provide enough incentive for change?
    Per Med 2015 Jun;12(3):231-235
    Medicine Institute, Cleveland Clinic, 9500 Euclid Avenue, NE5-203, Cleveland, OH 44195, USA.
    Personalized healthcare, which uses individual characteristics to better predict and prevent disease and customize therapies, is a potential solution to our current healthcare crisis. Personalized care aims to improve quality of care and reduce overall healthcare costs. Despite its potential, adoption of personalized healthcare has been slow for several reasons, one of which is related to financial incentives toward change. Read More

    Microbial bio-fuels: a solution to carbon emissions and energy crisis.
    Front Biosci (Landmark Ed) 2018 Jun 1;23:1789-1802. Epub 2018 Jun 1.
    Department of Environmental Microbiology, Babasaheb Bhimrao Ambedkar (Central) University, Raebarelly Road, Lucknow-226025, Uttar Pradesh, India,
    Increasing energy demand, limited fossil fuel resources and climate change have prompted development of alternative sustainable and economical fuel resources such as crop-based bio-ethanol and bio-diesel. However, there is concern over use of arable land that is used for food agriculture for creation of biofuel. Thus, there is a renewed interest in the use of microbes particularly microalgae for bio-fuel production. Read More

    Long noncoding RNA MEG3 inhibits proliferation of chronic myeloid leukemia cells by sponging microRNA21.
    Biomed Pharmacother 2018 May 14;104:181-192. Epub 2018 May 14.
    Department of Hematology, The Second Hospital of Hebei Medical University, Shijiazhuang, Hebei, China. Electronic address:
    The long noncoding RNA (lnc) maternally expressed 3 (MEG3) is downregulated in many types of cancers. However, the relationship between lncRNA MEG3, microRNA-21 (miR-21) and chronic myeloid leukemia (CML) blast crisis is unknown. This study examined bone marrow samples from 40 CML patients and 10 healthy donors. Read More

    Teaching mental health first aid in the school setting: a novel approach to improving outcomes for common adolescent mental disorders.
    Curr Opin Pediatr 2018 May 15. Epub 2018 May 15.
    Centre for Mental Health, Melbourne School of Population and Global Health, University of Melbourne, Parkville.
    Purpose Of Review: Common adolescent mental disorders, such as depression, often go untreated and severely impact health and educational outcomes. The purpose of this review is to describe what is currently known about school-based mental health interventions and to describe a new intervention, Mental Health First Aid training.

    Recent Findings: Universal and selective prevention and treatment programmes have been widely evaluated, though population-level dissemination remains elusive. Read More

    National Institute on Drug Abuse International Program: improving opioid use disorder treatment through international research training.
    Curr Opin Psychiatry 2018 May 15. Epub 2018 May 15.
    Consultant, IQ Solutions, Inc., Rockville, Maryland, USA.
    Purpose Of Review: For more than 25 years, the National Institute on Drug Abuse (NIDA) has supported research-training programs, establishing a global research network and expanding the knowledge base on substance use disorders. International research to inform approaches to opioid addiction is particularly important and relevant to the United States, where opioid misuse, addiction, and overdose constitute an emerging public health crisis. This article summarizes the NIDA International Program and illustrates its impact by reviewing recent articles about treatment approaches for opioid use disorders (OUD). Read More

    Perceived crisis and reforms: Issues, explanations, and remedies.
    Psychol Bull 2018 May 17. Epub 2018 May 17.
    Graduate School of Education, University of California, Los Angeles.
    An overview and discussion is made of the perceived replication crisis in terms of end problems, explanations, and remedies. Following a discussion of a published large-scale replication study and a review of the meta-analysis literature, we come to the conclusion that many effects are small and that on average the variance of the effects is roughly 10% to 25% of the population variance, most likely because of context dependencies. The proposed explanations such as questionable and suboptimal research practices (low power, poor measurement quality, and the use of NHST) are discussed, as well as more distal explanatory factors such as journals, funding agencies, and institutions. Read More

    A survival analysis of the last great European plagues: The case of Nonantola (Northern Italy) in 1630.
    Popul Stud (Camb) 2018 May 17:1-18. Epub 2018 May 17.
    a Bocconi University.
    This paper develops the first survival analysis of a large-scale mortality crisis caused by plague. For the time-to-event analyses we used the Cox proportional hazards regression model. Our case study is the town of Nonantola during the 1630 plague, which was probably the worst to affect Italy since the Black Death. Read More

    Single-layer ZnMN (M = Si, Ge, Sn) zinc nitrides as promising photocatalysts.
    Phys Chem Chem Phys 2018 May 17. Epub 2018 May 17.
    School of Materials Science and Engineering, Yancheng Institute of Technology, Yancheng 224051, P. R. China. and School of Physical Science and Technology, Nanjing Normal University, P.O. Box 210023, Nanjing, P. R. China.
    Searching for two-dimensional semiconductor materials that are suitable for visible-light photocatalytic water splitting provides a sustainable solution to deal with the future energy crisis and environmental problems. Herein, based on first-principles calculations, single-layer ZnMN2 (M = Si, Ge, Sn) zinc nitrides are proposed as efficient photocatalysts for water splitting. Stability analyses show that the single-layer ZnMN2 zinc nitrides exhibit energetic and dynamical stability. Read More

    Perceptions about Authentic Leadership Development: South African Occupational Therapy Students' Camp Experience.
    Occup Ther Int 2018 25;2018:1587906. Epub 2018 Mar 25.
    Department of Occupational Therapy, Thomas Jefferson University, 130 S. 9th Street, 632 Edison, Philadelphia, PA 19107, USA.
    Background: Twenty-three years into democracy, concern is deepening regarding the slow progress of Occupational Therapy (OT) in South Africa, especially with regard to diversity and inclusion within OT.

    Methods: This study explores authentic leadership development primarily among Black OT students attending a pilot Occupational Therapy Association of South Africa (OTASA) National Student Leadership Camp. It seeks to ascertain their perceptions on leadership and leadership development. Read More

    Zika virus: Where to from here?
    Can Commun Dis Rep 2018 Jan 4;44(1):27-28. Epub 2018 Jan 4.
    Centre for Food-borne and Zoonotic Infectious Diseases, Public Health Agency of Canada, Guelph, ON.
    After the waves of reported cases of infection with Zika virus swept across the Americas in 2015-16, the overall transmission of the virus in the Western Hemisphere declined in 2017. Between June 8 and August 31, 2017, only 16 new cases of Zika virus infection, all travel-related, were reported in Canada. This represents an 88% reduction in the cases recorded during the same time frame in 2016. Read More

    Similarities between military and medical service: stigma of seeking mental health assistance.
    J R Army Med Corps 2018 May 16. Epub 2018 May 16.
    Emergency Department, Calvary Public Hospital, Canberra, Australian Capital Territory, Australia.
    Studies have identified that there are many barriers to treatment of mental health illnesses in military populations, including the negative-associated stigma. One such barrier includes perceptions of weakness, leading to concerns about leadership and competency and being seen as malingering. Furthermore, similarities can be seen in civilian health professionals, where concerns of negative perceptions can limit reporting and treatment of mental health illnesses. Read More

    [The medicalization of life: hybrids against the dichotomy Nature/Culture].
    Cien Saude Colet 2018 May;23(5):1531-1539
    Instituto de Salud Colectiva, Universidad Nacional de Lanús. CONICET.Av.29de Septiembre 3901, Remedios de Escalada. Buenos Aires Argentina.
    This paper aims to analyze the process of medicalization in current societies, starting from the description of the way in which medicine gradually appropriated various aspects of everyday life that were once part of the life cycle of people. At the theoretical level, we are based on authors such as Descola and Latour, who problematize the dichotomy between Nature and Culture, and propose the need to think from a superior episteme. Methodologically, this theoretical proposal enables an analysis of the medicalization that can illuminate what is hidden in the discourse and biomedical practices: the sociocultural, political and economic processes that are part of these "objects" of Medicine. Read More

    More than just CO -recycling: corticular photosynthesis as a mechanism to reduce the risk of an energy crisis induced by low oxygen.
    New Phytol 2018 May 16. Epub 2018 May 16.
    Department of Applied Botany and Volcano Biology, University of Duisburg-Essen, Essen, 45117, Germany.
    Reassimilation of internal CO via corticular photosynthesis (PS ) has an important effect on the carbon economy of trees. However, little is known about its role as a source of O supply to the stem parenchyma and its implications in consumption and movement of O within trees. PS of young Populus nigra (black poplar) trees was investigated by combining optical micro-optode measurements with monitoring of stem chlorophyll fluorescence. Read More

    Supporting care home staff to manage residents' care safely and avoid admissions.
    Nurs Older People 2018 May 16. Epub 2018 May 16.
    care homes team, iCares, Central Clinic, Tipton, England.
    The community matron care homes team (CHT) was set up in Sandwell, West Midlands in 2011 to support care home staff to manage residents' care safely and reduce unplanned and/or avoidable use of acute health services. The service was reviewed in 2015 and attention focused on care homes with the highest levels of hospital use and emergency 999 services. Working with these care home staff and health professionals, a training and education opportunity to aid staff to manage residents in crisis was sourced, organised and implemented. Read More

    A Seasonal Time-Series Model Based on Gene Expression Programming for Predicting Financial Distress.
    Comput Intell Neurosci 2018 22;2018:1067350. Epub 2018 Mar 22.
    Department of Information Management, National Yunlin University of Science and Technology, 123 University Road, Section 3, Douliou, Yunlin 64002, Taiwan.
    The issue of financial distress prediction plays an important and challenging research topic in the financial field. Currently, there have been many methods for predicting firm bankruptcy and financial crisis, including the artificial intelligence and the traditional statistical methods, and the past studies have shown that the prediction result of the artificial intelligence method is better than the traditional statistical method. Financial statements are quarterly reports; hence, the financial crisis of companies is seasonal time-series data, and the attribute data affecting the financial distress of companies is nonlinear and nonstationary time-series data with fluctuations. Read More

    Soluble and Cell-Cell-Mediated Drivers of Proteasome Inhibitor Resistance in Multiple Myeloma.
    Front Endocrinol (Lausanne) 2018 1;9:218. Epub 2018 May 1.
    Reagan Laboratory, Maine Medical Center Research Institute, Scarborough, ME, United States.
    It is becoming clear that myeloma cell-induced disruption of the highly organized bone marrow components (both cellular and extracellular) results in destruction of the marrow and support for multiple myeloma (MM) cell proliferation, survival, migration, and drug resistance. Since the first phase I clinical trial on bortezomib was published 15 years ago, proteasome inhibitors (PIs) have become increasingly common for treatment of MM and are currently an essential part of any anti-myeloma combination therapy. PIs, either the first generation (bortezomib), second generation (carfilzomib) or oral agent (ixazomib), all take advantage of the heavy reliance of myeloma cells on the 26S proteasome for their degradation of excessive or misfolded proteins. Read More

    The path to VICTORy - a beginner's guide to success using commercial research antibodies.
    J Cell Sci 2018 May 15;131(10). Epub 2018 May 15.
    Commercial research antibodies are crucial tools in modern cell biology and biochemistry. In the USA some $2 billion a year are spent on them, but many are apparently not fit-for-purpose, and this may contribute to the 'reproducibility crisis' in biological sciences. Inadequate antibody validation and characterization, lack of user awareness, and occasional incompetence amongst suppliers have had immense scientific and personal costs. Read More

    Cancer mortality in Serbia, 1991-2015: an age-period-cohort and joinpoint regression analysis.
    Cancer Commun (Lond) 2018 Apr 10;38(1):10. Epub 2018 Apr 10.
    Faculty of Medicine, University of Belgrade, Belgrade, 11000, Serbia.
    Background: As the result of dramatic political changes, civil wars, and a long-term refugee crisis from the end of the last to beginning of this century, the population of Serbia has experienced significant health problems. The aim of this study was to assess cancer mortality trends in Serbia.

    Methods: This nationwide study was carried out to analyze cancer mortality in Serbia during 1991-2015 using official data. Read More

    A scoping review of reporting 'Ethical Research Practices' in research conducted among refugees and war-affected populations in the Arab world.
    BMC Med Ethics 2018 May 15;19(1):36. Epub 2018 May 15.
    Department of Epidemiology and Population Health, Faculty of Health Sciences, American University of Beirut, Beirut, Lebanon.
    Background: Ethical research conduct is a cornerstone of research practice particularly when research participants include vulnerable populations. This study mapped the extent of reporting ethical research practices in studies conducted among refugees and war-affected populations in the Arab World, and assessed variations by time, country of study, and study characteristics.

    Methods: An electronic search of eight databases resulted in 5668 unique records published between 2000 and 2013. Read More

    Prognostic Factors of Renal Involvement in Systemic Sclerosis.
    Kidney Blood Press Res 2018 May 10;43(3):682-689. Epub 2018 May 10.
    Department of Clinical Medicine-Scleroderma Unit, Sapienza University of Rome, Rome, Italy.
    Background/aims: Renal involvement is common in systemic sclerosis (SSc), including asymptomatic reduction of glomerular filtration rate (GFR), increased renal resistance indices, scleroderma renal crisis (SRC) and ANCA-associated vasculitis. The aim was to evaluate type and evolution of renal involvement for a period of five years.

    Methods: 121 SSc patients (100 F, 21 M) with mean age of 54. Read More

    John Foster Dulles, his medical history and its impact on Cold War politics.
    J Med Biogr 2018 Jan 1:967772018771432. Epub 2018 Jan 1.
    2 Department of Radiation Oncology, School of Medicine, Duke University, Durham, NC, USA.
    John Foster Dulles was the United States Secretary of State during the administration of President Dwight D Eisenhower. At the height of the Cold War, Dulles was Eisenhower's emissary, traveling over 450,000 international miles, leading United States foreign policy. In November of 1956, during an international crisis involving the Suez Canal, Dulles became ill and underwent an operation for a perforated colon cancer. Read More

    Pathways and mechanisms linking dietary components to cardiometabolic disease: thinking beyond calories.
    Obes Rev 2018 May 14. Epub 2018 May 14.
    Children's Hospital Oakland Research Institute, Oakland, CA, USA.
    Calories from any food have the potential to increase risk for obesity and cardiometabolic disease because all calories can directly contribute to positive energy balance and fat gain. However, various dietary components or patterns may promote obesity and cardiometabolic disease by additional mechanisms that are not mediated solely by caloric content. Researchers explored this topic at the 2017 CrossFit Foundation Academic Conference 'Diet and Cardiometabolic Health - Beyond Calories', and this paper summarizes the presentations and follow-up discussions. Read More

    Adverse effects of media reports on the treatment of osteoporosis.
    J Endocrinol Invest 2018 May 14. Epub 2018 May 14.
    New Mexico Clinical Research and Osteoporosis Center, 300 Oak St. NE, Albuquerque, NM, 87106, USA.
    Purpose: The review focused on the role that media reporting plays in the level of public awareness about osteoporosis and its influence on osteoporosis treatment decisions.

    Methods: We reviewed the literature on the role of media on three main aspects influencing patient adherence to osteoporosis treatment: the awareness of osteoporosis as a major health problem, the perception of the effectiveness of osteoporosis medications, and the fear of adverse effects with osteoporosis medications.

    Results: A review of the literature confirmed what is routinely observed in clinical practice-that media report can strongly influence the level of awareness of osteoporosis and fracture risk. Read More

    Vascular Aging and Cognitive Dysfunction: Silent Midlife Crisis in the Brain.
    Pulse (Basel) 2018 Mar 26;5(1-4):127-132. Epub 2017 Oct 26.
    Institute of Public Health, National Yang-Ming University, Taipei, ROC.
    Background: Vascular aging may cause cerebral microvascular damage and cognitive dysfunction. There is incremental evidence that consistently implicates arterial stiffness being involved in the manifestation of cognitive impairment in the elderly. However, few investigations have examined the relationship between arterial stiffness and cognitive impairment in midlife. Read More

    Overview of Cerebral Edema During Correction of Hyperglycemic Crises.
    Am J Case Rep 2018 May 15;19:562-566. Epub 2018 May 15.
    Division of Nephrology, Denver Health Medical Center, Denver, CO, USA.
    BACKGROUND Hyperglycemic crises can cause severe neurologic impairment. One of the most dreaded consequences of hyperglycemic crises is cerebral edema, a rare complication seen during the treatment of hyperglycemic crises resulting from overly-aggressive fluid resuscitation and rapid correction of hyperglycemia and hyperosmolarity. CASE REPORT We present a case of profound hyperglycemic crisis with blood glucose greater than 2000 mg/dL, complicated by the development of new neurologic deficits after rapid correction of hyperglycemia. Read More

    Using eye tracking technology to compare the effectiveness of malignant hyperthermia cognitive aid design.
    Korean J Anesthesiol 2018 May 15. Epub 2018 May 15.
    Department of Anesthesiology, Perioperative and Pain Medicine, Stanford University School of Medicine; Stanford, CA.
    Background: Malignant hyperthermia is a rare but potentially fatal complication of anesthesia, and several different cognitive aids designed to facilitate a timely and accurate response to this crisis currently exist. Eye tracking technology can measure voluntary and involuntary eye movements, gaze fixation within an area of interest, and speed of visual response and has been used to a limited extent in anesthesiology.

    Methods: With eye tracking technology, we compared the accessibility of five malignant hyperthermia cognitive aids by collecting gaze data from twelve volunteer participants. Read More

    [Hypertensive crisis and anticholinergic toxidrome secondary to accidental consumption of datura stramonium in two children].
    Ann Cardiol Angeiol (Paris) 2018 May 11. Epub 2018 May 11.
    Faculté de médecine, université Ahmed-Benbellah, 31000 Oran, Algérie.
    Objective: To identify a hypertensive clinical form of atropine or anticholinergic toxidrome secondary to accidental consumption of Datura seeds.

    Patients And Methods: We report two cases of Datura intoxication in two children who presented marked anticholinergic syndrome whose diagnosis was made by the anamnesis and the clinic.

    Result: Patient 1: A 5-year-old boy, returns home agitated with balance disorders. Read More

    Emerging Infectious Diseases, Antimicrobial Resistance and Millennium Development Goals: Resolving the Challenges through One Health.
    Cent Asian J Glob Health 2013 1;2(2):76. Epub 2013 Oct 1.
    Department of Veterinary Clinical Sciences, College of Veterinary Medicine, Washington State University, Pullman, WA.
    Most emerging infectious diseases are zoonoses, which could severely hamper reaching the targets of millennium development goals (MDG). Five out of the total eight MDG's are strongly associated with the Emerging Infectious Diseases (EIDs). Recent emergence and dissemination of drug-resistant pathogens has accelerated and prevent reaching the targets of MDG, with shrinking of therapeutic arsenal, mostly due to antimicrobial resistance (AMR). Read More

    Why rely on friends instead of family? The role of exchanges and civic engagement in a rural sub-Saharan African context.
    Afr Stud 2017 25;76(4):579-596. Epub 2017 Oct 25.
    George Mason University, University of Maryland, and University of Pennsylvania.
    Social science research has shown there is a nearly universal norm of seeking assistance from family members in times of need. However, when do individuals prefer to rely on friends, rather than family members, when they need support? This question has not been carefully addressed. To fill this gap in the literature we examine why rural Malawians - who typically have strong bonds with kin - might prefer to rely on friends instead of family if a crisis were to occur. Read More

    'The Great Fiasco' of the 1948 presidential election polls: status recognition and norms conflict in social science.
    Ann Sci 2018 May 14:1-25. Epub 2018 May 14.
    a Department of Business, Technology and Engineering , University of California , Berkeley , USA.
    All three 'scientific' pollsters (Crossley, Gallup and Roper) wrongly predicted incumbent President Harry Truman's defeat in the 1948 presidential election, and thus faced a potentially serious legitimacy crisis. This 'fiasco' occurred at a most inopportune time. Social science was embroiled in a policy debate taking place in the halls of Congress. Read More

    'Friends that last a lifetime': the importance of emotions amongst volunteers working with refugees in Calais.
    Br J Sociol 2018 May 13. Epub 2018 May 13.
    Independent Researcher.
    The European 'refugee crisis' has generated a broad movement of volunteers offering their time and skills to support refugees across the continent, in the absence of nation states. This article focuses on volunteers who helped in the informal refugee camp in Calais called the 'Jungle'. It looks at the importance of emotions as a motivating factor for taking on responsibilities that are usually carried out by humanitarian aid organizations. Read More

    Perioperative Management of Sickle Cell Disease.
    Mediterr J Hematol Infect Dis 2018 1;10(1):e2018032. Epub 2018 May 1.
    Yale University School of Medicine, Yale New Haven Health, Bridgeport Hospital, United States.
    Over 30 million people worldwide have sickle cell disease (SCD). Emergent and non-emergent surgical procedures in SCD have been associated with relatively increased risks of peri-operative mortality, vaso-occlusive (painful) crisis, acute chest syndrome, post-operative infections, congestive heart failure, cerebrovascular accident and acute kidney injury. Pre-operative assessment must include a careful review of the patient's known crisis triggers, baseline hematologic profile, usual transfusion requirements, pre-existing organ dysfunction and opioid use. Read More

    Kuhnian revolutions in neuroscience: the role of tool development.
    Biol Philos 2018 4;33(3):17. Epub 2018 May 4.
    Department of Physiology, Development and Neuroscience, University of Cambridge, Cambridge, CB2 3DY UK.
    The terms "paradigm" and "paradigm shift" originated in "The Structure of Scientific Revolutions" by Thomas Kuhn. A paradigm can be defined as the generally accepted concepts and practices of a field, and a paradigm shift its replacement in a scientific revolution. A paradigm shift results from a crisis caused by anomalies in a paradigm that reduce its usefulness to a field. Read More

    Criminality in Greece during the years of financial crisis: 2008-2014.
    Psychiatriki 2018 Jan-Mar;29(1):19-24
    1st Department of Psychiatry, National and Kapodistrian University of Athens, Eginition Hospital, Athens, Greece.
    The link between poverty, unemployment and economic downturns and increases in crime rates has long been the subject of social science study. However, the relationships between these phenomena has not been studied sufficiently and through time in most European countries that suffered, or, like Greece, are still suffering the recent financial crisis. We examined if the recent financial crisis in Greece has coincided with an increase in crime, analyzing crime rates since the start of the financial crisis and over an extensive time period (7 years). Read More

    Successful pregnancy in maple syrup urine disease: a case report and review of the literature.
    Nutr J 2018 May 12;17(1):51. Epub 2018 May 12.
    Department of General Pediatrics, Adolescent Medicine and Neonatology, Medical Center - University of Freiburg, Faculty of Medicine, Mathildenstraße 1, 79106, Freiburg, Germany.
    Background: Maple syrup urine disease (MSUD) is an autosomal recessive disorder of branched-chain amino acid metabolism. Patients with MSUD are at risk of life-threatening metabolic decompensations with ketoacidosis and encephalopathy. These episodes are often triggered by physiological stress. Read More

    Bioconjugated nano-bactericidal complex for potent activity against human and phytopathogens with concern of global drug resistant crisis.
    Sci Total Environ 2018 May 9;637-638:274-281. Epub 2018 May 9.
    Bionanotechnological Laboratory, Department of Studies in Microbiology, Manasagangotri, University of Mysore, Mysore 570 006, Karnataka, India. Electronic address:
    The present study emphasizes the need for novel antimicrobial agents to combat the global drug resistant crisis. The development of novel nanomaterials is reported to be of the alternative tool to combat drug resistant pathogens. In present investigation, bioconjugated nano-complex was developed from secondary metabolite secreted from endosymbiont. Read More

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