Curr Opin Microbiol 2018 Mar 12;45:70-76. Epub 2018 Mar 12.
Department of Molecular Genetics, University of Toronto, Toronto, Ontario M5G 1M1, Canada. Electronic address:
Microorganisms have a remarkable capacity to evolve resistance to antimicrobial agents, threatening the efficacy of the limited arsenal of antimicrobials and becoming a dire public health crisis. This is of particular concern for fungal pathogens, which cause devastating invasive infections with treatment options limited to only three major classes of antifungal drugs. The paucity of antifungals with clinical utility is in part due to close evolutionary relationships between these eukaryotic pathogens and their human hosts, which limits the unique targets to be exploited therapeutically. Read More