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    Error Detection-Based Model to Assess Educational Outcomes in Crisis Resource Management Training: A Pilot Study.
    Otolaryngol Head Neck Surg 2017 Apr 1:194599817697946. Epub 2017 Apr 1.
    1 Department of Otolaryngology-Head and Neck Surgery, McGill University, Montréal, Canada.
    Otolaryngology-head and neck surgery (OTL-HNS) residents face a variety of difficult, high-stress situations, which may occur early in their training. Since these events occur infrequently, simulation-based learning has become an important part of residents' training and is already well established in fields such as anesthesia and emergency medicine. In the domain of OTL-HNS, it is gradually gaining in popularity. Read More

    [Mexican Asthma Guidelines: GUIMA 2017].
    Rev Alerg Mex 2017 ;64 Suppl 1:s11-s128
    Secretaría de Salud, Instituto Nacional de Enfermedades Respiratorias, Dirección General. Ciudad de México, México.
    Background: The need for a national guideline, with a broad basis among specialists and primary care physicians was felt in Mexico, to try unifying asthma management. As several high-quality asthma guidelines exist worldwide, it was decided to select the best three for transculturation.

    Methods: Following the internationally recommended methodology for guideline transculturation, ADAPTE, a literature search for asthma guidelines, published 1-1-2007 through 31-12-2015 was conducted. Read More

    Refugee health and rehabilitation: Challenges and response.
    J Rehabil Med 2017 Apr 21. Epub 2017 Apr 21.
    Department of Rehabilitation Medicine, Royal Melbourne Hospital, 34-54 Poplar Road, Parkville, Melbourne, Victoria 3052, Australia.
    Background: The current global refugee crisis poses major challenges in providing effective healthcare to refugees, particularly for non-communicable diseases (NCDs) management and disability. This article provides an overview of refugee health and potential challenges from the rehabilitation perspective.

    Methods: A literature search (both academic and grey literature) was conducted using medical and health science electronic databases and internet search engines (2001-2016). Read More

    Remittances as aid following major sudden-onset natural disasters.
    Disasters 2017 Apr 25. Epub 2017 Apr 25.
    Master's degree candidates at the Munk School of Global Affairs, University of Toronto, Canada, at the time of the study.
    There is a general assumption, based on macroeconomic studies, that remittances will rise following major sudden-onset natural disasters. This is confirmed by a few assessments involving country-specific research, and usually short-term data. This study, questioning conventional wisdom, reviewed and graphed annual and quarterly remittance flows using International Monetary Fund and World Bank data from 2000-14 for 12 countries that confronted 18 major natural disasters. Read More

    Political drivers of epidemic response: foreign healthcare workers and the 2014 Ebola outbreak.
    Disasters 2017 Apr 25. Epub 2017 Apr 25.
    Lecturer in Public Policy, School of Social and Political Sciences, University of Melbourne, Australia.
    This study demonstrates that countries responded quite differently to calls for healthcare workers (HCWs) during the Ebola epidemic in West Africa in 2014. Using a new dataset on the scale and timing of national pledges and the deployment of HCWs to states experiencing outbreaks of the virus disease (principally, Guinea, Liberia, and Sierra Leone), it shows that few foreign nations deployed HCWs early, some made pledges but then fulfilled them slowly, and most sent no HCWs at all. To aid understanding of such national responses, the paper reviews five theoretical perspectives that offer potentially competing or complementary explanations of foreign government medical assistance for international public health emergencies. Read More

    The Development of a Veterans Health Administration Emergency Management Research Agenda.
    PLoS Curr 2017 Mar 23;9. Epub 2017 Mar 23.
    VA Greater Los Angeles Healthcare System, VA HSR&D Center for the Study of Healthcare Innovation, Implementation and Policy (CSHIIP), North Hills, California, United States.
    Introduction: The Veterans Health Administration (VHA), the largest integrated healthcare delivery system in the United States, is charged with ensuring timely access to high-quality care for veterans during disasters, and supporting national, state, local, and tribal emergency management and homeland security efforts. In 2008, the VHA Office of Public Health (OPH) sponsored the first VHA Emergency Management Research Agenda-setting conference to develop research priorities that address the needs of veterans and to position VHA as a national leader in emergency management by having VHA serve as a "laboratory" for the development of evidence-based emergency management practices.

    Methods: We focused on four steps: #1: Appraising the emergency management research portfolio of VHA-based researchers; #2: Obtaining systematic information on VHA's role in emergency management and the healthcare needs of veterans during disasters; #3: Based upon gaps between the current research portfolio and the existing evidence base, identifying strategic priorities using a research agenda-setting conference; and #4: Laying the groundwork to foster the conduct of emergency management research within VHA. Read More

    Chronic complications and quality of life of patients living with sickle cell disease and receiving care in three hospitals in Cameroon: a cross-sectional study.
    BMC Hematol 2017 20;17. Epub 2017 Apr 20.
    Department of Internal Medicine and Pediatrics, Faculty of Health Sciences, University of Buea, Buea, Cameroon.
    Background: Sickle Cell Disease (SCD) is associated with chronic multisystem complications that significantly influence the quality of life (QOL) of patients early in their life. Although sub-Saharan Africa bears 75% of the global burden of SCD, there is a paucity of data on these complications and their effects on the QOL. We aimed to record these chronic complications, to estimate the QOL, and to identify the corresponding risk factors in patients with SCD receiving care in three hospitals in Cameroon. Read More

    Prevention practices influencing frequency of occurrence of vaso-occlusive crisis among sickle cell patients in Abeokuta South Local Government Area of Ogun State, Nigeria.
    BMC Hematol 2017 20;17. Epub 2017 Apr 20.
    Department of Community Medicine and Primary Care, Olabisi Onabanjo University Teaching Hospital, Sagamu, Nigeria.
    Background: Africa is the most affected continent with 200,000 new born affected by sickle cell anemia annually with of 5% of under five deaths. Nigeria has the largest sickle cell gene pool in the world with about 2% of all babies born to Nigerian parents. This study therefore sets out to assess the prevention practices influencing the frequency of occurrence of vaso-occlusive crisis among patients in Ogun State. Read More

    Extrastriatal changes in patients with late-onset glutaric aciduria type I highlight the risk of long-term neurotoxicity.
    Orphanet J Rare Dis 2017 Apr 24;12(1):77. Epub 2017 Apr 24.
    Department of Neuroradiology, University Hospital Heidelberg, Im Neuenheimer Feld 400, 60120, Heidelberg, Germany.
    Background: Without neonatal initiation of treatment, 80-90% of patients with glutaric aciduria type 1 (GA1) develop striatal injury during the first six years of life resulting in a complex, predominantly dystonic movement disorder. Onset of motor symptoms may be acute following encephalopathic crisis or insidious without apparent crisis. Additionally, so-called late-onset GA1 has been described in single patients diagnosed after the age of 6 years. Read More

    "She Would Be Flailing Around Distressed": The Critical Role of Home-Based Palliative Care for Patients with Advanced Cancer.
    J Palliat Med 2017 Feb 16. Epub 2017 Feb 16.
    5 Division of General Internal Medicine, University of California , San Francisco, San Francisco, California.
    Background: Patients with advanced cancer experience significant symptoms, ineffective treatments, and hospice underutilization. Home-based palliative care (HBPC) may fill a service gap for patients who require intensive home management, but are not enrolled in hospice. Even as data emerge on the utilization impacts of HBPC, other impacts are not as well known. Read More

    Good Cop, Better Cop: Evaluation of a Geriatrics Training Program for Police.
    J Am Geriatr Soc 2017 Apr 24. Epub 2017 Apr 24.
    Division of Geriatrics, University of California, San Francisco, California.
    Objectives: To develop, implement, and evaluate a training program in aging-related health for police officers.

    Design: Cross-sectional.

    Setting: Crisis intervention training program for police officers in San Francisco. Read More

    The Vision of "Industrie 4.0" in the Making-a Case of Future Told, Tamed, and Traded.
    Nanoethics 2017 25;11(1):107-121. Epub 2017 Jan 25.
    Department of Sociology, Faculty of Business, Economics and Social Sciences, University of Hohenheim, Wollgrasweg 23, 70599 Stuttgart, Germany.
    Since industrial trade fair Hannover Messe 2011, the term "Industrie 4.0" has ignited a vision of a new Industrial Revolution and has been inspiring a lively, ongoing debate among the German public about the future of work, and hence society, ever since. The discourse around this vision of the future eventually spread to other countries, with public awareness reaching a temporary peak in 2016 when the World Economic Forum's meeting in Davos was held with the motto "Mastering the Fourth Industrial Revolution. Read More

    Unravelling the mysteries of sudden unexpected death in epilepsy.
    Neurologia 2017 Apr 18. Epub 2017 Apr 18.
    Klinik für Epileptologie, Universitätsklinikum Bonn, Bonn, Alemania.
    Introduction: Sudden unexpected death in epilepsy (SUDEP) is the most frequent cause of premature death in epileptic patients. Most SUDEP events occur at night and frequently go unnoticed; the exact pathophysiological mechanisms of this phenomenon therefore remain undetermined. Nevertheless, most cases of SUDEP are attributed to an infrequent yet extremely severe complication of epileptic seizures. Read More

    Beyond integrated care.
    J Health Serv Res Policy 2017 Jan 1:1355819617697998. Epub 2017 Jan 1.
    4 Professor, Utrecht School of Governance, Utrecht University, Utrecht, the Netherlands.
    Integrated care tops the health care agenda. But more integration alone will not remedy the crisis in health care, and there is a danger in the increasingly prevalent conceptualization of care integration as a goal in itself rather than as an instrument for improving performance. Operating integrated care systems, staffed by an overly specialized medical workforce, is unsustainable in terms of human and financial resources and is likely to produce little benefit for patients with multi-morbidity. Read More

    Stuck in fragments: Population genetics of the Endangered collared brown lemur Eulemur collaris in the Malagasy littoral forest.
    Am J Phys Anthropol 2017 Apr 21. Epub 2017 Apr 21.
    Department of Social Sciences, Oxford Brookes University, Oxford, United Kingdom.
    Objectives: The Endangered collared brown lemur (Eulemur collaris) is the largest primate living in the littoral forest of southeastern Madagascar, a top priority habitat for biodiversity conservation on the island. Because this lemur is a key seed-disperser, an evaluation of the structure and connectivity of the populations surviving in the forest fragments is urgently needed to guide conservation plans.

    Materials And Methods: Genetic variability at autosomal microsatellites and mitochondrial DNA was investigated in a total of 49 collared brown lemurs sampled by non-invasive methods in three littoral forest fragments and in the nearby lowland humid forest. Read More

    Integrating biogeography, threat and evolutionary data to explore extinction crisis in the taxonomic group of cycads.
    Ecol Evol 2017 Apr 21;7(8):2735-2746. Epub 2017 Mar 21.
    Department of GeographyEnvironmental Management and Energy StudiesUniversity of JohannesburgJohannesburgSouth Africa.
    Will the ongoing extinction crisis cause a severe loss of evolutionary information accumulated over millions of years on the tree of life? This question has been largely explored, particularly for vertebrates and angiosperms. However, no equivalent effort has been devoted to gymnosperms. Here, we address this question focusing on cycads, the gymnosperm group exhibiting the highest proportion of threatened species in the plant kingdom. Read More

    A general framework for predicting delayed responses of ecological communities to habitat loss.
    Sci Rep 2017 Apr 20;7(1):998. Epub 2017 Apr 20.
    Institute of Statistics & Department of Applied Mathematics, National Chung Hsing University, 250 Kuo Kuang Road, Taichung, 40227, Taiwan, ROC.
    Although biodiversity crisis at different spatial scales has been well recognised, the phenomena of extinction debt and immigration credit at a crossing-scale context are, at best, unclear. Based on two community patterns, regional species abundance distribution (SAD) and spatial abundance distribution (SAAD), Kitzes and Harte (2015) presented a macroecological framework for predicting post-disturbance delayed extinction patterns in the entire ecological community. In this study, we further expand this basic framework to predict diverse time-lagged effects of habitat destruction on local communities. Read More

    Biodiversity losses and conservation responses in the Anthropocene.
    Science 2017 Apr;356(6335):270-275
    Long-Term Ecology Laboratory, Landcare Research, Post Office Box 69040, Lincoln 7640, New Zealand.
    Biodiversity is essential to human well-being, but people have been reducing biodiversity throughout human history. Loss of species and degradation of ecosystems are likely to further accelerate in the coming years. Our understanding of this crisis is now clear, and world leaders have pledged to avert it. Read More

    Profile and professional expectations of medical students from 11 Latin American countries: the Red-LIRHUS project.
    BMC Res Notes 2017 Apr 20;10(1):159. Epub 2017 Apr 20.
    Escuela de Medicina, Universidad Peruana de Ciencias Aplicadas, Lima, Peru.
    Background: Latin America is undergoing a human resource crisis in health care in terms of labor shortage, misdistribution and poor orientation to primary care. Workforce data are needed to inform the planning of long-term strategies to address this problem. This study aimed to evaluate the academic and motivational profile, as well as the professional expectations, of Latin American medical students. Read More

    Inside the nation's largest mental health institution: a prevalence study in a state prison system.
    BMC Public Health 2017 Apr 20;17(1):342. Epub 2017 Apr 20.
    Department of Epidemiology, University of Iowa School of Public Health, Iowa City, IA, USA.
    Background: The United States has the highest incarceration rate in the world which has created a public health crisis. Correctional facilities have become a front line for mental health care. Public health research in this setting could inform criminal justice reform. Read More

    Adolescent Depression: Differential Symptom Presentations in Deaf and Hard-of-Hearing Youth Using the Patient Health Questionnaire-9.
    J Deaf Stud Deaf Educ 2017 Apr;22(2):195-203
    University of South Florida.
    The present study examined differences in symptom presentation in screening for pediatric depression via evaluation of the Patient Health Questionnaire-9 (PHQ-9). In particular, we examined whether PHQ-9 items function differentially among deaf and hard-of-hearing (DHH; n = 75) and hearing (n = 75) youth based on participants recruited from crisis assessment services. Multiple indicators multiple causes models were used to examine whether items of the PHQ-9 functioned differently between groups as well as whether there were group differences in the mean severity of depressive symptoms. Read More

    An Outbreak of Endogenous Fungal Endophthalmitis Among Intravenous Drug Abusers in New England.
    JAMA Ophthalmol 2017 Apr 20. Epub 2017 Apr 20.
    New England Eye Center, Department of Vitreoretinal Surgery, Tufts University School of Medicine, Boston, Massachusetts.
    Importance: Intravenous drug abuse (IVDA) is a known risk factor for endogenous fungal endophthalmitis (EFE), a severe intraocular infection caused by hematogenous seeding of mycotic organisms to the eye. Reporting significant increases in heroin-related deaths since 2014, the New England region is in the midst of an opioid crisis that has led to a substantial increase in patients at risk for this vision-threatening disease.

    Objective: To present an update on characteristics, management, and visual outcomes in patients with EFE. Read More

    Reductions in Hard Drug Use Among Homeless Youth Receiving a Strength-Based Outreach Intervention: Comparing the Long-Term Effects of Shelter Linkage Versus Drop-in Center Linkage.
    Subst Use Misuse 2017 Jun 22;52(7):905-915. Epub 2017 Feb 22.
    b Department of Human Sciences , The Ohio State University , Columbus , Ohio , USA.
    Objectives: The current study sought to test hard drug use outcomes for youth receiving a strengths-based outreach and advocacy intervention that linked youth to either a shelter or a drop-in center.

    Methods: Homeless youth (14-24 years old) were engaged by research assistants (RAs) at soup kitchens, parks, libraries, and other locations that homeless youth were known to frequent. Youth were randomly assigned to receive six months of advocacy that focused on linking youth to a drop-in center (n = 40) or to a crisis shelter (n = 39). Read More

    Hydroxyurea (hydroxycarbamide) for sickle cell disease.
    Cochrane Database Syst Rev 2017 Apr 20;4:CD002202. Epub 2017 Apr 20.
    Department of Haematology, Guy's and St Thomas' Hospitals NHS Foundation Trust, Great Maze Pond, London, UK, SE1 9RT.
    Background: Sickle cell disease (SCD) is one of the most common inherited diseases worldwide. It is associated with lifelong morbidity and a reduced life expectancy. Hydroxyurea (hydroxycarbamide), an oral chemotherapeutic drug, ameliorates some of the clinical problems of SCD, in particular that of pain, by raising fetal haemoglobin. Read More

    Health problems of newly arrived migrants and refugees in Europe.
    J Travel Med 2017 Jul;24(4)
    Office for Travel Medicine, Department for Interventions in Health-Care Facilities, Hellenic Center for Disease Control and Prevention, 3-5 Agrafon street, Marousi, 15123, Greece.
    Background.: The number of migrants and refugees in Europe in the past few years has increased dramatically due to war, violence or prosecutions in their homeland. Migration may affect physical, mental and social health. Read More

    Efficacy of Some Wearable Devices Compared with Spray-On Insect Repellents for the Yellow Fever Mosquito, Aedes aegypti (L.) (Diptera: Culicidae).
    J Insect Sci 2017 Jan;17(1)
    Department of Biology, New Mexico State University, 1200 S. Horseshoe Dr, Las Cruces, NM 88003.
    The current Zika health crisis in the Americas has created an intense interest in mosquito control methods and products. Mosquito vectors of Zika are of the genus Aedes, mainly the yellow fever mosquito, Aedes aegypti. L. Read More

    Vertically Aligned Graphene Sheets Membrane for Highly Efficient Solar Thermal Generation of Clean Water.
    ACS Nano 2017 Apr 19. Epub 2017 Apr 19.
    Efficient utilization of solar energy for clean water is an attractive, renewable and environment-friendly way to solve the long-standing water crisis. For this task, we prepared the long-range vertically aligned graphene sheets membrane (VA-GSM) as the highly efficient solar thermal converter for generation of clean water. The VA-GSM was prepared by the antifreeze-assisted freezing technique we developed, which possessed the run-through channels facilitating the water transport, high light absorption capacity for excellent photothermal transduction, and the extraordinary stability in rigorous conditions. Read More

    Trial Design and Endpoint Evaluation in Clinical Studies Addressing Chronic Back Pain.
    Spine (Phila Pa 1976) 2017 Apr 18. Epub 2017 Apr 18.
    Adjunct Associate Professor Johns Hopkins University Anesthesiology and Critical Care 47 Orchard Lane Colts Neck, New Jersey 07722 7323800200.
    Study Design: A review of the literature evaluating clinical trials of chronic back pain.

    Objective: To assist physicians in assessing the quality of clinical trial data to make the most informed treatment decisions.

    Summary Of Background Data: Chronic pain is a tremendous public health issue, affecting close to 100 million adults in the United States, and costs the American people billions of dollars. Read More

    The value of doing your best.
    • Authors:
    Nurs Stand 2017 Apr;31(34):37
    Claire Matata is lead nurse for emergency and acute clinical research at Northumbria Specialist Emergency Care Hospital. She completed her degree in adult nursing at the University of Liverpool in 2010, and has worked in thoracic surgery, community and prison nursing and as a specialist research nurse and senior clinician in urgent care. In 2015, she spent three months in Sierra Leone during the Ebola crisis. Read More

    A Survey of School Nurse Emergency Preparedness 2014-2015.
    J Sch Nurs 2017 Jan 1:1059840517704702. Epub 2017 Jan 1.
    4 Health and Medical Services, Houston Independent School District, Houston, TX, USA.
    Well-prepared school nurses are more likely to handle emergencies properly. Thus, assessing crisis management preparedness is important. In August 2014, a questionnaire was sent to 275 nurses in a large Texas school system to collect data about nurse and school characteristics, emergency frequency and management, and equipment availability. Read More

    Current Perspectives on Viable but Non-culturable State in Foodborne Pathogens.
    Front Microbiol 2017 4;8:580. Epub 2017 Apr 4.
    Department of Food Science and Nutrition, Zhejiang Key Laboratory for Agro-Food Processing, Zhejiang UniversityHangzhou, China.
    The viable but non-culturable (VBNC) state, a unique state in which a number of bacteria respond to adverse circumstances, was first discovered in 1982. Unfortunately, it has been reported that many foodborne pathogens can be induced to enter the VBNC state by the limiting environmental conditions during food processing and preservation, such as extreme temperatures, drying, irradiation, pulsed electric field, and high pressure stress, as well as the addition of preservatives and disinfectants. After entering the VBNC state, foodborne pathogens will introduce a serious crisis to food safety and public health because they cannot be detected using conventional plate counting techniques. Read More

    Influence maternal background has on children's mental health.
    Int J Equity Health 2017 Apr 18;16(1):63. Epub 2017 Apr 18.
    Research Group on Statistics, Econometrics and Health (GRECS), University of Girona, Carrer de la Universitat de Girona 10, Campus de Montilivi, 17003, Girona, Spain.
    Background: In this paper, we aim to discern how a mother's health and her socioeconomic determinants may influence her children's mental health. In addition to this, we also evaluate the influence of other household characteristics and whether or not the economic downturn has heightened the effect a parent's social gradient has on their children's mental health.

    Methods: We use samples comprised of 4-14-year-old minors from the 2006 Spanish National Health Survey (SNHS), undertaken prior to the crisis, and the 2011 SNHS, carried out during the crisis. Read More

    Social determinants of antibiotic misuse: a qualitative study of community members in Haryana, India.
    BMC Public Health 2017 Apr 19;17(1):333. Epub 2017 Apr 19.
    Department of Medicine, University of Wisconsin, School of Medicine and Public Health, Madison, WI, USA.
    Background: Antibiotic resistance is a global public health crisis. In India alone, multi-drug resistant organisms are responsible for over 58,000 infant deaths each year. A major driver of drug resistance is antibiotic misuse, which is a pervasive phenomenon worldwide. Read More

    Talking about intimate partner violence in multi-cultural antenatal care: a qualitative study of pregnant women's advice for better communication in South-East Norway.
    BMC Pregnancy Childbirth 2017 Apr 19;17(1):123. Epub 2017 Apr 19.
    Faculty of Health Sciences, Department of Nursing and Health Promotion, Oslo and Akershus University College of Applied Sciences, St. Olavs Plass, P.O. Box 4, 0310, Oslo, Norway.
    Background: Intimate partner violence (IPV) against women constitutes a major public health problem. Antenatal care is considered a window of opportunity to disclose and to communicate about IPV. However, little is known about how women from different ethnic backgrounds wish to communicate about their experiences with IPV during pregnancy in antenatal care. Read More

    Our Shared Vulnerability to Dangerous Pathogens.
    Med Law Rev 2017 Apr 17. Epub 2017 Apr 17.
    O'Neill Institute for National and Global Health Law, Georgetown University, Washington DC, USA.
    The international community vastly underestimates the risk and scale of our shared vulnerability to fast moving pathogens. Ranging from SARS and novel influenzas to Ebola and Zika, the world seems to be caught off guard, despite the regularity of global health threats historically. More importantly, when governments and international institutions underestimate the threat, they also underinvest in preparedness. Read More

    Risk and Outbreak Communication: Lessons from Taiwan's Experiences in the Post-SARS Era.
    Health Secur 2017 Mar/Apr;15(2):165-169
    In addition to the impact of a disease itself, public reaction could be considered another outbreak to be controlled during an epidemic. Taiwan's experience with SARS in 2003 highlighted the critical role played by the media during crisis communication. After the SARS outbreak, Taiwan's Centers for Disease Control (Taiwan CDC) followed the WHO outbreak communication guidelines on trust, early announcements, transparency, informing the public, and planning, in order to reform its risk communication systems. Read More

    Upstreaming and Normalizing Advance Care Planning Conversations-A Public Health Approach.
    Behav Sci (Basel) 2017 Apr 12;7(2). Epub 2017 Apr 12.
    School of Nursing, Case Western Reserve University, 2120 Cornell Road, Cleveland, OH 44106, USA.
    As a society, we simply don't talk about this universal experience called dying and death; in fact, we ignore it until we have to face it. Thus, it is often in a crisis experience when we have to make decisions while we are laden with uncertainty and intense emotions. Sixty percent of people say making sure their family is not burdened by tough decisions is extremely important, yet 56% of them have not held a conversation about its context. Read More

    A crisis of protection and safe passage: violence experienced by migrants/refugees travelling along the Western Balkan corridor to Northern Europe.
    Confl Health 2017 16;11. Epub 2017 Apr 16.
    Médecins Sans Frontières, Operational Research Unit (LuxOR) MSF Brussels Operational Center, Luxembourg, Luxembourg.
    Background: Pushed by ongoing conflicts and pulled by the desire for a better life, over one million migrants/refugees transited Balkan countries and arrived in Europe during 2015 and early 2016. To curb this influx, European countries instituted restrictive migration policies often characterized by building of razor-wire border fences and border closures. Among migrants/refugees who received mental health care in Serbia while travelling through Balkan countries to Northern Europe, we assessed the prevalence and patterns of violent events experienced including physical trauma. Read More

    TKI rotation-induced persistent deep molecular response in multi-resistant blast crisis of Ph+ CML.
    Oncotarget 2017 Apr;8(14):23061-23072
    Department of Laboratory Medicine, Medical University of Vienna, Austria.
    In chronic myeloid leukemia (CML) resistance against one or more BCR-ABL1 tyrosine kinase inhibitors (TKI) remains a clinical challenge. Preclinical data suggest that TKI combinations may overcome resistance. We report on a heavily pre-treated 78 year-old female patient with CML who developed multi-resistant blast crisis with bone marrow fibrosis and a Ph- clone. Read More

    Changes in directly alcohol-attributable mortality during the great recession by employment status in Spain: a population cohort of 22 million people.
    J Epidemiol Community Health 2017 Apr 17. Epub 2017 Apr 17.
    National School of Public Health, Carlos III Health Institute, Madrid, Spain.
    Background: Macroeconomic fluctuations can impact differentially on alcohol-related problems across sociodemographic groups. We assess trend changes in directly alcohol-attributable (DAA) mortality in the population aged 25-64 during the post-2008 recession in Spain according to employment status and other sociodemographic factors.

    Methods: Nationwide cohort study covering 21. Read More

    Management of Childhood Congenital Adrenal Hyperplasia-An Integrative Review of the Literature.
    J Pediatr Health Care 2017 Apr 13. Epub 2017 Apr 13.
    Congenital adrenal hyperplasia (CAH) is an endocrine condition that requires parents to administer steroids up to three times daily, supplementing maintenance doses with oral or injectable doses during times of illness. The purpose of this integrative review was to explore the management, care, and associated health issues for children with CAH and the family response to the condition. Four literature indexes were searched, with 39 articles included. Read More

    Earthquakes, Fuel Crisis, Power Outages, and Health Care in Nepal: Implications for the Future.
    Disaster Med Public Health Prep 2017 Apr 18:1-8. Epub 2017 Apr 18.
    7Department of Microbiology,Lumbini Medical College,Palpa,Nepal.
    Earthquakes are a major natural calamity with pervasive effects on human life and nature. Similar effects are mimicked by man-made disasters such as fuel crises and power outages in developing countries. Natural and man-made disasters can cause intangible human suffering and often leave scars of lifelong psychosocial damage. Read More

    Effectiveness of current policing-related mental health interventions in England and Wales and Crisis Intervention Teams as a future potential model: a systematic review.
    Syst Rev 2017 Apr 17;6(1):85. Epub 2017 Apr 17.
    Institute of Mental Health, University of Nottingham, Nottingham, UK.
    Background: Experiencing mental ill health adds a layer of complexity for individuals in touch with the justice system and for those responsible for working in the justice service with these individuals, such as frontline police officers. In England and Wales, there are three commonly used but not necessarily commonly designed or operated, mental health interventions associated with policing, Liaison and Diversion, Street Triage and specialist staff embedded in Police Contact Control Rooms. A fourth US designed model, Crisis Intervention Teams (CITs), is now attracting some interest in England and Wales, and these four are to be considered in this review. Read More

    Suppression of PKC causes oncogenic stress for triggering apoptosis in cancer cells.
    Oncotarget 2017 Mar 9. Epub 2017 Mar 9.
    Center for Drug Discovery, Northeastern University, Boston, USA.
    Gain of functional mutations in ras occurs in more than 30% of human malignancies and in particular 90% of pancreatic cancer. Mutant ras, via activating multiple effector pathways, not only promote cell growth or survival, but also apoptosis, depending upon cell types or circumstances. In order to further study the mechanisms of apoptosis induced by oncogenic ras, we employed the ras loop mutant genes and demonstrated that Akt functioned downstream of Ras in human pancreatic cancer or HPNE cells ectopically expressing mutated K-ras for the induction of apoptosis after the concurrent suppression of PKC α and β. Read More

    Hope Amidst Horror: Documenting The Effects of The "War On Drugs" Among Female Sex Workers and Their Intimate Partners in Tijuana, Mexico.
    Med Anthropol 2017 Apr 17. Epub 2017 Apr 17.
    Sensationalistic media coverage has fueled stereotypes of the Mexican border city of Tijuana as a violent battleground of the global drug war. While the drug war shapes health and social harms in profoundly public ways, less visible are the experiences and practices of hope that forge communities of care and represent more private responses to this crisis. In this article, we draw on ethnographic fieldwork and photo elicitation with female sex workers who inject drugs and their intimate, non-commercial partners in Tijuana to examine the personal effects of the drug war. Read More

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