52,560 results match your criteria Myxedema Coma or Crisis


An Update on Addison's Disease.

Exp Clin Endocrinol Diabetes 2018 Dec 18. Epub 2018 Dec 18.

Department of Medicine III, University Hospital Carl Gustav Carus, Dresden, Germany.

Addison's disease - the traditional term for primary adrenal insufficiency (PAI) - is defined as the clinical manifestation of chronic glucocorticoid- and/or mineralocorticoid deficiency due to failure of the adrenal cortex which may result in an adrenal crisis with potentially life-threatening consequences. Even though efficient and safe pharmaceutical preparations for the substitution of endogenous gluco- and mineralocorticoids are established in therapy, the mortality in patients with PAI is still increased and the health-related quality of life (HRQoL) is often reduced.PAI is a rare disease but recent data report an increasing prevalence. Read More

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http://dx.doi.org/10.1055/a-0804-2715DOI Listing
December 2018

Decoding systems biology of plant stress for sustainable agriculture development and optimized food production.

Prog Biophys Mol Biol 2018 Dec 15. Epub 2018 Dec 15.

National Centre for Biological Sciences (TIFR), GKVK Campus, Bangalore, 560065, India. Electronic address:

Plants are essential facilitators of human life on planet earth. Plants play a critical functional role in mediating the quality of air, availability of food and the sustainability of agricultural resources. However, plants are in constant interaction with its environment and often hampered by various types of stresses like biotic and abiotic ones. Read More

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http://dx.doi.org/10.1016/j.pbiomolbio.2018.12.002DOI Listing
December 2018

Tobacco smoking in China: a pulmonary health crisis.

Authors:
Eric L Flenaugh

Curr Opin Pulm Med 2018 Dec 17. Epub 2018 Dec 17.

Pulmonary, Interventional Pulmonary, & Critical Care Medicine, Morehouse School of Medicine, Atlanta, Georgia, USA.

Purpose Of Review: China's economy has had tremendous growth through the principle of command economy, where profitable private industries become government-owned and managed. The tobacco industry, which generates 10% of the annual governmental income from the country's over 300 million smokers, serves as a prime example. The present review takes an in-depth look at how the success of the government's tobacco industry has caused a pulmonary health crisis for the country with the world's largest population; and in turn, poses a threat to global lung health. Read More

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http://dx.doi.org/10.1097/MCP.0000000000000556DOI Listing
December 2018

3D hierarchical g-C3N4 architectures assembled by ultrathin self-doped nanosheets: extremely facile HMTA activation and superior photocatalytic hydrogen evolution.

ACS Appl Mater Interfaces 2018 Dec 18. Epub 2018 Dec 18.

Photocatalytic hydrogen evolution has broad prospects as a clean solution for the energy crisis. However, the rational design of catalyst complex, the H2 evolution efficiency, and the yield are great challenge. Herein, 3D hierarchical g-C3N4 architectures assembled by ultrathin carbon rich nanosheets (3D CCNS) were prepared via an extremely facile hexamethylenetetramine (HMTA) activation approach at bulk scale, indicating the validation of scale-up production process. Read More

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http://dx.doi.org/10.1021/acsami.8b17757DOI Listing
December 2018

Morbidity pattern and interferon gamma level in sickle cell anemia patients with autosplenectomy.

Niger J Clin Pract 2018 Dec;21(12):1615-1621

Department of Immunology, Faculty of Basic Medical Science, College of Medicine, University of Ibadan, Ibadan, Nigeria.

Introduction: In sickle cell anemia patients (SCA), the spleen suffers multiple occlusion of its microvasculature causing ischemia and subsequently autosplenectomy. Among the functions of the spleen is the production of gamma interferon (IFN-γ) which has several immunological roles. This function could be impaired in these patients. Read More

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http://dx.doi.org/10.4103/njcp.njcp_217_18DOI Listing
December 2018

Child & Adolescent Emergency Mental Health Crisis: A Neglected Cohort

Authors:
F McNicholas

Ir Med J 2018 Dec 6;111(10):841. Epub 2018 Dec 6.

School of Medicine and Medical Science, University College Dublin, Dublin 4

Aims To highlight the ongoing concern regarding the mental health well-being of children and adolescents in Ireland and access to appropriate and timely MH services. Methods With reference to existing literature and policy planning documents, this paper presents an over view of child and adolescent MH services (CAMHS) and paediatric liaison psychiatry services (PLPs) along with their respective roles in the management of children presenting with acute MH crisis. Results Despite longstanding and growing public and professional awareness of unequal and inadequate MH services for youth, progress has been slow. Read More

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December 2018

Clinical Observations, Plasma Retinol Concentrations, and In Vitro Lymphocyte Functions in Children With Sickle Cell Disease.

Ochsner J 2018 ;18(4):308-317

Department of Pediatrics, Louisiana State University Health Sciences Center, New Orleans, LA.

Background: Children with sickle cell disease (SCD) often have infections, growth deficits, and impaired immunity, problems that also are observed in individuals with a vitamin A deficiency (plasma retinol concentration <20 μg/dL). The goal of this study was to investigate the association between vitamin A, health status, and the in vitro immune function of children with SCD.

Methods: Fifty-nine children (40 SS, 11 SC, and 8 Sβ [Sβ] hemoglobin genotypes) 9 months to 18 years old were investigated for plasma levels of retinol, retinol binding protein, C-reactive protein, alpha-1-acid glycoprotein, lymphocyte proliferation, and interleukin (IL)-2 activity in supernatant of phytohemagglutinin-treated lymphocytes. Read More

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http://dx.doi.org/10.31486/toj.17.0044DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6292479PMC
January 2018

Reconciliation and Canada's overdose crisis: responding to the needs of Indigenous Peoples.

CMAJ 2018 Dec;190(50):E1466-E1467

British Columbia Centre on Substance Use (Lavalley, Kastor, Valleriani, McNeil); Western Aboriginal Harm Reduction Society (Kastor); Department of Medicine (Valleriani, McNeil), University of British Columbia, St. Paul's Hospital, Vancouver, BC

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http://dx.doi.org/10.1503/cmaj.181093DOI Listing
December 2018

Improvement in renal prognosis with prompt hemodialysis in hyperosmolar hyperglycemic state-related rhabdomyolysis: A case report.

Medicine (Baltimore) 2018 Dec;97(50):e13647

Division of Endocrinology and Metabolism, Department of Internal Medicine, Chang Gung Memorial Hospital, Chang Gung University, Taoyuan City, Taiwan.

Rationale: Acute kidney injury is common and correctable in patients with a hyperosmolar hyperglycemic state (HHS). Nevertheless, hyperglycemic crisis may also contribute to the development of rhabdomyolysis, which can worsen renal function and lead to high mortality in such patients.

Patient Concerns: Herein, we report a case of hyperosmolar hyperglycemic state-related rhabdomyolysis and acute renal failure with an excellent outcome. Read More

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http://dx.doi.org/10.1097/MD.0000000000013647DOI Listing
December 2018

Where You Find Yourself: From Chaos Through Crisis to Redemption.

Authors:
Tim Langguth

Northwest Dent 2016 09;95(5):16-9, 21-2, 24-5

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September 2016

Acute Cancer Cognitive Therapy.

Cogn Behav Pract 2014 Nov 28;21(4):404-415. Epub 2014 Mar 28.

Memorial Sloan-Kettering, Cancer Center.

The utility of cognitive therapy (CT) for ambulatory cancer patients is clear but the acute cancer setting significantly shapes the therapeutic interaction, parameters, and delivery of CT. In this article, we describe how to apply CT to acute cancer settings, focusing on how this approach differs from traditionally taught, ambulatory CT. We highlight the importance of a tailored history and formulation, how the cognitive model is applied within an acute cancer context to promote coping and adaptation. Read More

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http://dx.doi.org/10.1016/j.cbpra.2014.03.003DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6291221PMC
November 2014

Deviancy, Dependency, and Disability: the Forgotten History of Eugenics and Mass Incarceration.

Authors:
Laura I Appleman

Duke Law J 2018 Dec;68(3):417-78

Willamette University.

Three widely discussed explanations of the punitive carceral state are racism, harsh drug laws, and prosecutorial overreach. These three narratives, however, only partially explain how our correctional system expanded to its current overcrowded state. Neglected in our discussion of mass incarceration is our largely forgotten history of the long-term, wholesale institutionalization of the disabled. Read More

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December 2018

Extracellular polymeric substances of biofilms: Suffering from an identity crisis.

Water Res 2018 Nov 28;151:1-7. Epub 2018 Nov 28.

Department of Biotechcnology, Delft University of Technology, Delft, the Netherlands. Electronic address:

Microbial biofilms can be both cause and cure to a range of emerging societal problems including antimicrobial tolerance, water sanitation, water scarcity and pollution. The identities of extracellular polymeric substances (EPS) responsible for the establishment and function of biofilms are poorly understood. The lack of information on the chemical and physical identities of EPS limits the potential to rationally engineer biofilm processes, and impedes progress within the water and wastewater sector towards a circular economy and resource recovery. Read More

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http://dx.doi.org/10.1016/j.watres.2018.11.020DOI Listing
November 2018

Early intervention for bereaved children: What mental health professionals think.

Death Stud 2018 Dec 17:1-9. Epub 2018 Dec 17.

a Center for Crisis Psychology, Faculty of Psychology , University of Bergen , Bergen , Norway.

People rarely specify what "early intervention" following bereavement means, so we explored the views of experienced professionals working primarily with bereaved children. In an anonymous online survey, 84 mental health professionals answered questions about the content and timeframe of early intervention. The types of interventions varied, but conversation and support were most frequent. Read More

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http://dx.doi.org/10.1080/07481187.2018.1531086DOI Listing
December 2018

Autism's existential crisis: a reflection on Livingston et al. (2018).

J Child Psychol Psychiatry 2019 Jan;60(1):111-113

Yale Child Study Center, New Haven, CT, USA.

Livingston and colleagues present an empirical investigation of the compensatory framework describing the autism clinical phenotype as the sum of intrinsic neurocognitive deficits and compensatory mechanisms. This commentary highlights several methodologic features of the study that are pertinent to interpretation and reflects on the reduction of social behavior to cognitive processes. Taken together, the notion of compensation calls into question the validity and utility of the current behavioral diagnosis of autism. Read More

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http://dx.doi.org/10.1111/jcpp.12989DOI Listing
January 2019

Recent review on subclass B1 metallo-β-lactamases inhibitors: Sword for Antimicrobial Resistance.

Curr Drug Targets 2018 Dec 16. Epub 2018 Dec 16.

Shivalik college of Pharmacy. India.

An emerging crisis of antibiotic resistance for microbial pathogens is alarming all the nations posing a global threat to human health. The production of metallo-β-lactamase enzyme is the most powerful strategy of bacteria to produce resistance. An efficient way to combat this global health threat is the development of broad/non-specific type of metallo-β-lactamase inhibitors, which can inhibit the different isoforms of the enzyme. Read More

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http://dx.doi.org/10.2174/1389450120666181217101812DOI Listing
December 2018

The Relationship Between Foreclosures and Intimate Partner Violence During the U.S. Housing Crisis.

J Interpers Violence 2018 Dec 17:886260518818431. Epub 2018 Dec 17.

2 Arizona State University, Tempe, USA.

The recent U.S. housing crisis led to increases in neighborhood foreclosures and stress. Read More

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http://dx.doi.org/10.1177/0886260518818431DOI Listing
December 2018

Reversible spontaneous EMG activity during myasthenic crisis: Two case reports.

eNeurologicalSci 2019 Mar 20;14:16-18. Epub 2018 Nov 20.

Department of Clinical Neurophysiology, National Hospital for Neurology and Neurosurgery, Queen Square, London, UK.

Background: Myasthenia Gravis (MG) is an antibody-mediated autoimmune neuromuscular disorder, clinically presenting with fatigable variable muscle weakness. Typical electrodiagnostic findings are a decremental response to repetitive nerve stimulation with post-exercise facilitation, and motor unit instability expressed as increased jitter on single fibre-EMG. Presence of spontaneous activity on standard EMG is traditionally considered inconsistent with a diagnosis of MG and would direct the differential diagnosis towards a primary denervating or usually inflammatory myopathic process. Read More

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http://dx.doi.org/10.1016/j.ensci.2018.11.024DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6275166PMC

Risky business: Data on trading results for UK general insurance firms during and after the global financial crisis.

Data Brief 2018 Dec 26;21:2384-2389. Epub 2018 Nov 26.

Leicester Castle Business School De Montfort University, LE1 9BH Leicester, United Kingdom.

This article contains dataset on the trading results for UK general insurance industry performance during and after the global financial crisis. The data covers the net written premiums by line of business and trading results for UK general insurance firms over a decade period (2007-2016). Additionally, the data comprises areas that are peculiar to evaluate general insurance business such as net written premiums, underwriting results, claims incurred, investment income and trading results which makes it important to investigate the probability of default of different business lines and insolvency risk. Read More

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http://dx.doi.org/10.1016/j.dib.2018.11.105DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6280591PMC
December 2018

Resilience and learning from insurance firms: Dataset on British long-term insurance market performance.

Data Brief 2018 Dec 24;21:2360-2366. Epub 2018 Nov 24.

Portsmouth Business School, University of Portsmouth, PO1 3DE Portsmouth, UK.

This data article revealed data about the UK long-term insurance market performance for over a decade. The data was acquired from the ABI and contains important trading results (i.e. Read More

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http://dx.doi.org/10.1016/j.dib.2018.11.098DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6280597PMC
December 2018

The Nociceptin Receptor (NOP) Agonist AT-312 Blocks Acquisition of Morphine- and Cocaine-Induced Conditioned Place Preference in Mice.

Front Psychiatry 2018 29;9:638. Epub 2018 Nov 29.

Department of Pharmaceutical Sciences, College of Pharmacy, Western University of Health Sciences, Pomona, CA, United States.

Treatment of drug addiction remains an unmet medical need due to the dearth of approved pharmacotherapies. There are no approved treatments for cocaine addiction, whereas the current opioid crisis has revealed the stark reality of the limited options to treat prescription and illicit opioid abuse. Preclinical studies in rodents and nonhuman primates have shown that orphanin FQ/nociceptin (N/OFQ), the endogenous ligand for the nociceptin opioid receptor (NOP) reduces the rewarding effects of several abused substances, including opioids, psychostimulants and alcohol. Read More

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http://dx.doi.org/10.3389/fpsyt.2018.00638DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6281746PMC
November 2018

Advances in Achieving Opioid Analgesia Without Side Effects.

Front Pharmacol 2018 29;9:1388. Epub 2018 Nov 29.

Department of Experimental Anesthesiology, Charité - Universitätsmedizin Berlin, Corporate Member of Freie Universität Berlin, Humboldt-Universität zu Berlin, and Berlin Institute of Health, Berlin, Germany.

Opioids are the most effective drugs for the treatment of severe pain, but they also cause addiction and overdose deaths, which have led to a worldwide opioid crisis. Therefore, the development of safer opioids is urgently needed. In this article, we provide a critical overview of emerging opioid-based strategies aimed at effective pain relief and improved side effect profiles. Read More

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http://dx.doi.org/10.3389/fphar.2018.01388DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6282113PMC
November 2018

Dopamine DR antagonist VK4-116 attenuates oxycodone self-administration and reinstatement without compromising its antinociceptive effects.

Neuropsychopharmacology 2018 Nov 27. Epub 2018 Nov 27.

Molecular Targets and Medications Discovery Branch, National Institute on Drug Abuse, Intramural Research Program, Baltimore, MD, 21224, USA.

Prescription opioids such as oxycodone are highly effective analgesics for clinical pain management, but their misuse and abuse have led to the current opioid epidemic in the United States. In order to ameliorate this public health crisis, the development of effective pharmacotherapies for the prevention and treatment of opioid abuse and addiction is essential and urgently required. In this study, we evaluated-in laboratory rats-the potential utility of VK4-116, a novel and highly selective dopamine D3 receptor (D3R) antagonist, for the prevention and treatment of prescription opioid use disorders. Read More

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http://dx.doi.org/10.1038/s41386-018-0284-5DOI Listing
November 2018

Perspectives on ethnic and racial disparities in Alzheimer's disease and related dementias: Update and areas of immediate need.

Alzheimers Dement 2018 Dec 13. Epub 2018 Dec 13.

Department of Pharmacology & Neuroscience, University of North Texas Health Science Center, Fort Worth, TX, USA. Electronic address:

Alzheimer's disease and related dementias (ADRDs) are a global crisis facing the aging population and society as a whole. With the numbers of people with ADRDs predicted to rise dramatically across the world, the scientific community can no longer neglect the need for research focusing on ADRDs among underrepresented ethnoracial diverse groups. The Alzheimer's Association International Society to Advance Alzheimer's Research and Treatment (ISTAART; alz. Read More

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http://dx.doi.org/10.1016/j.jalz.2018.09.009DOI Listing
December 2018

Temporal trends in opioid prescribing for common general surgical procedures in the opioid crisis era.

Am J Surg 2018 Dec 8. Epub 2018 Dec 8.

Department of Surgery, Mount Sinai Hospital, New York, NY, USA. Electronic address:

Background: Recent data has demonstrated that postoperative patients are at risk of chronic opioid abuse. It is unknown whether surgeon postoperative opioid prescribing changed as the opioid crisis entered its peak.

Methods: The Institutional Data Warehouse was queried to identify patients who underwent three common elective ambulatory procedures between 2014 and 2018 (n = 3495), including: laparoscopic cholecystectomy, laparoscopic inguinal hernia repair (IHR), and open IHR. Read More

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http://dx.doi.org/10.1016/j.amjsurg.2018.11.047DOI Listing
December 2018

Systemic sclerosis induced by the use of cocaine: is there an association?

Rheumatol Int 2018 Dec 15. Epub 2018 Dec 15.

Division of Rheumatology, Hospital das Clinicas HCFMUSP, Faculdade de Medicina, Universidade de Sao Paulo, Av. Dr. Arnaldo, 455 -3° andar, sala 3131, Cerqueira César, São Paulo, CEP 01246-903, Brazil.

The association between cocaine abuse and systemic sclerosis (SSc) is rarely described. Two new cases of this association are presented: two young adults, after using inhaled cocaine for a few years, were diagnosed with SSc. While a 24 year-old white female patient presented with diffuse SSc with multiple digital ulcers and scleroderma renal crisis (SRC), a 27 year-old male patient presented limited SSc with skin ulcers and digital gangrene, rapidly evolving to death due to massive intestinal hemorrhage. Read More

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http://dx.doi.org/10.1007/s00296-018-4227-6DOI Listing
December 2018
1 Read

Medical populism.

Soc Sci Med 2018 Dec 7;221:1-8. Epub 2018 Dec 7.

University of Canberra, Australia. Electronic address:

Medical emergencies are staple features of today's 24/7 culture of breaking news. As politics becomes increasingly stylised, audiences fragmented, and established knowledge claims contested, health crises have become even more vulnerable to politicisation. We offer the vocabulary of medical populism to make sense of this phenomenon. Read More

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https://linkinghub.elsevier.com/retrieve/pii/S02779536183067
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http://dx.doi.org/10.1016/j.socscimed.2018.12.006DOI Listing
December 2018
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Epidemiology of Antibiotic Resistance in Lebanese Extra-Hospital Settings: an overview.

J Glob Antimicrob Resist 2018 Dec 12. Epub 2018 Dec 12.

Laboratoire Microbiologie Santé et Environnement (LMSE), Ecole Doctorale des Sciences et de Technologie, Faculté de Santé Publique, Université Libanaise, Tripoli, Lebanon. Electronic address:

Antibiotics can truly be considered the symbol of the 20th century's miracle drugs. However, excessive and inappropriate use of antibiotics in human and veterinary medicine has led to repercussions in terms of mortality, morbidity, and financial and societal costs, especially with the lack of novel drugs to combat infections caused by resistant pathogens. Unfortunately, antimicrobial resistance (AMR) has increased significantly worldwide in the past decades, particularly in developing third-world countries. Read More

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http://dx.doi.org/10.1016/j.jgar.2018.11.019DOI Listing
December 2018

Cross-country evidence on the social determinants of the post-socialist mortality crisis in Europe: a review and performance-based hierarchy of variables.

Sociol Health Illn 2018 Dec 14. Epub 2018 Dec 14.

Department of Economics, University of Massachusetts, USA.

An unprecedented mortality crisis befell the former socialist countries between 1989 and 1995, representing one of the greatest demographic shocks of the period after the Second World War. While it is likely that country-level variation in the post-socialist mortality crisis in Eastern Europe can be explained by a constellation of political and socio-economic factors, no comprehensive review of the existing scholarly attempts at explaining these factors exists. We review 39 cross-national multi-variable peer reviewed studies of social determinants of mortality in post-socialist Europe in order to assess the social factors behind the post-socialist mortality crisis, determine the gaps in the existing literature and to make suggestions for future research. Read More

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https://onlinelibrary.wiley.com/doi/abs/10.1111/1467-9566.12
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http://dx.doi.org/10.1111/1467-9566.12846DOI Listing
December 2018
2 Reads

The Drug Shortage Crisis in the United States: Impact on Cancer Pharmaceutical Safety.

Cancer Treat Res 2019 ;171:75-92

University of Colorado Denver, Denver, CO, USA.

Drug shortages pose a significant public health concern in the United States, and cancer drugs are among those most affected. Shortages present serious safety risks for patients and substantial burden on providers and the healthcare system. Multifaceted drivers of this complex problem include manufacturing disruptions, raw material shortages, regulatory issues, market dynamics, and limited financial incentives that reward quality and production of off-patent drugs. Read More

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http://link.springer.com/10.1007/978-3-319-43896-2_6
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http://dx.doi.org/10.1007/978-3-319-43896-2_6DOI Listing
January 2019
1 Read

A novel hypertensive crisis rat model established by excessive norepinephrine infusion and the potential therapeutic effects of Rho-kinase inhibitors on it.

Biomed Pharmacother 2019 Jan 26;109:1867-1875. Epub 2018 Nov 26.

State Key Laboratory of Bioactive Substances and Functions of Natural Medicines, Institute of Materia Medica, Chinese Academy of Medical Sciences and Peking Union Medical College, 100050, Beijing, China; Beijing Key Laboratory of Drug Targets Identification and Drug Screening, Institute of Materia Medica, Chinese Academy of Medical Sciences and Peking Union Medical College, 100050, Beijing, China. Electronic address:

Hypertension crisis is a severe disease and needs emergency treatment in clinic. It is an important task to discover novel drugs which could lower the blood pressure steadily and quickly. However, animal models for screening anti-hypertensive crisis agents are unsatisfactory. Read More

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https://linkinghub.elsevier.com/retrieve/pii/S07533322183655
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http://dx.doi.org/10.1016/j.biopha.2018.11.061DOI Listing
January 2019
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Network localization of heterogeneous neuroimaging findings.

Brain 2018 Dec 14. Epub 2018 Dec 14.

Berenson-Allen Center for Noninvasive Brain Stimulation, Department of Neurology, Beth Israel Deaconess Medical Center, Harvard Medical Center, Boston, MA, USA.

Studies of the same disease often implicate different brain regions, contributing to a perceived reproducibility crisis in neuroimaging. Here, we leverage the normative human brain connectome to test whether seemingly heterogeneous neuroimaging findings localize to connected brain networks. We use neurodegenerative disease, and specifically Alzheimer's disease, as our example as it is one of the diseases that has been studied the most using neuroimaging. Read More

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http://dx.doi.org/10.1093/brain/awy292DOI Listing
December 2018
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The More You Know: Identifying Factors Associated With Inpatient Mortality Related to Opioid Overdose Can Drive Progress in the Opioid Health Crisis.

Anesth Analg 2019 Jan;128(1):16-18

Department of Anesthesiology, University of Michigan School of Medicine, Ann Arbor, Michigan.

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http://dx.doi.org/10.1213/ANE.0000000000003902DOI Listing
January 2019

Heterogeneity of Treatment Effects of Long-Acting Injectable Antipsychotic Medications.

J Clin Psychiatry 2018 Nov 27;80(1). Epub 2018 Nov 27.

Department of Psychiatry and Health Behaviors, Augusta University Health, Augusta, Georgia, USA.

Objective: To investigate subgroup responses to long-acting injectable (LAI) medications haloperidol decanoate (HD) and paliperidone palmitate (PP) in a randomized controlled trial that found no difference between the treatments on the primary outcome of efficacy failure.

Methods: A Comparison of Long-Acting Injectable Medications for Schizophrenia (ACLAIMS) enrolled 311 participants from March 2011 to July 2013 meeting DSM-IV-TR criteria for diagnoses of schizophrenia or schizoaffective disorder at risk of relapse due to medication nonadherence or substance abuse. Participants were randomly assigned to double-blinded treatment with HD or PP and followed for up to 2 years. Read More

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http://dx.doi.org/10.4088/JCP.18m12109DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6296243PMC
November 2018
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Does the agglomeration effect occur in the hospital sector? The impact of agglomeration economies on the financial performance of hospitals-An evidence from Poland.

Int J Health Plann Manage 2018 Dec 14. Epub 2018 Dec 14.

Department of Corporate Finance, Faculty of Economics and Sociology, University of Lodz, Lodz, Poland.

The main aim of the article is to analyze the occurrence of agglomeration effect in the hospital sector on the basis of financial performance. The considerations are made on the example of hospitals in Poland-the country that survived the latest economic crisis relatively well, usually generating positive values of GDP, but where still there is an ongoing discussion on the final shape of healthcare financing model. The article is based on the assumption that there occur significant differences in financial performance between hospitals according to their location. Read More

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http://dx.doi.org/10.1002/hpm.2716DOI Listing
December 2018

Myxoedema coma in a 2-year-old girl with untreated congenital hypothyroidism: Case report and literature review.

J Paediatr Child Health 2018 Dec 12. Epub 2018 Dec 12.

Department of Pediatrics, Faculty of Medicine Ramathibodi Hospital, Mahidol University, Bangkok, Thailand.

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http://dx.doi.org/10.1111/jpc.14339DOI Listing
December 2018

Compassion in nursing: Solution or stereotype?

Nurs Inq 2018 Dec 11:e12271. Epub 2018 Dec 11.

Warwick Research in Nursing, Warwick Medical School, University of Warwick, Coventry, UK.

Compassion in healthcare has received significant attention recently, on an international scale, with concern raised about its absence during clinical interactions. As a concept, compassionate care has been linked to nursing. We examined historical discourse on this topic, to understand and situate current debates on compassionate care as a hallmark of high-quality services. Read More

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https://onlinelibrary.wiley.com/doi/abs/10.1111/nin.12271
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http://dx.doi.org/10.1111/nin.12271DOI Listing
December 2018
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A problem shared is a problem halved? Comparing burdens arising for family caregivers of patients with disorders of consciousness in institutionalized versus at home care.

BMC Psychol 2018 Dec 14;6(1):58. Epub 2018 Dec 14.

Department of Psychology, University of Bielefeld, Bielefeld, Germany.

Background: Disorders-of-consciousness (DOC) are rare conditions leading to very severe physical and mental disabilities. Providing care for DOC patients has been described as a stressful experience, eroding the physical and psychological health of the caregiver. Different forms of care may have different impacts on the caregivers and institutionalized care has been suggested to have an unburdening effect, but this possibility has never been empirically studied. Read More

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http://dx.doi.org/10.1186/s40359-018-0272-xDOI Listing
December 2018
1 Read

The value of an embedded qualitative study in a trial of a second antidepressant for people who had not responded to one antidepressant: understanding the perspectives of patients and general practitioners.

BMC Fam Pract 2018 Dec 14;19(1):197. Epub 2018 Dec 14.

Centre for Academic Primary Care, Oakfield House, Oakfield Grove, Clifton, Bristol, BS8 2BN, UK.

Background: Depression is the leading cause of disability worldwide, and is a major contributor to the overall global burden of disease. The number of prescriptions for antidepressants has risen dramatically in recent years yet up to 50% of patients who are treated for depression with antidepressants do not report feeling better as a result of treatment, and do not show the desired improvement on depression measures. We report a qualitative study embedded in a trial of second antidepressant for people who had not responded to one antidepressant, exploring the acceptability of a combination of antidepressants from the perspectives of both patients and practitioners, together with experiences of participating in a clinical trial. Read More

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http://dx.doi.org/10.1186/s12875-018-0877-4DOI Listing
December 2018

Managing stake and accountability in Prime Ministers' accounts of the "refugee crisis": A longitudinal analysis.

J Community Appl Soc Psychol 2018 Nov-Dec;28(6):406-429. Epub 2018 Nov 8.

Department of Social Research University of Helsinki Helsinki Finland.

Taking a (critical) discursive psychological approach, the present study explores the identity management of the Finnish and Swedish Prime Ministers (PM) in relation to the "refugee crisis" and their countries' asylum policies. By taking a longitudinal approach and analysing the PMs' accounts of the "refugee crisis" from 1-year period, we focused on the ways rhetorical devices related to ethos, logos, and pathos were used to manage the issues of stake and accountability, as well as on the ways in which categories were worked up to serve particular functions. Our comparative analysis demonstrated significant similarities in the Finnish and Swedish PMs' talk, especially with regard to the transfer from a discourse of pathos and ethos, describing refugees in terms of individualism and humaneness, to a discourse of logos, emphasizing rationality, justifying sharpened immigration policies, and homogenizing refugees. Read More

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http://dx.doi.org/10.1002/casp.2358DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6282806PMC
November 2018

Changes in income-related inequalities in cervical cancer screening during the Spanish economic crisis: a decomposition analysis.

Int J Equity Health 2018 Dec 13;17(1):184. Epub 2018 Dec 13.

Department of Applied Economics, Public Economics and Political Economy, School of Economics, Complutense University of Madrid, Campus de Somosaguas, 28223 Pozuelo de Alarcón, Madrid, Spain.

Background: Cervical cancer is one of the most prevalent cancers, but it may be prevented by early detection. Social inequalities in the use of cytology testing have been identified in the literature. However, the degree of income-related inequality has not been quantified and determinants of inequality changes during the economic crisis remain unknown. Read More

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http://dx.doi.org/10.1186/s12939-018-0894-xDOI Listing
December 2018

The gingival health status of 8-12 year-old children in Damascus city in Syria during the Syrian Crisis: a cross-sectional epidemiological oral health survey.

BMC Res Notes 2018 Dec 13;11(1):887. Epub 2018 Dec 13.

Paediatric Dentistry Department, Faculty of Dentistry, Damascus University, Damascus, Syria.

Objective: The aim of this study was to assess the current gingival health status in children aged 8-12 years in Damascus city. No contemporary data was available with an immense need for studies evaluating the gingival health status in Syrian children, especially under the current circumstances of the Syrian crisis.

Results: The study followed the school-based health survey model using stratified random cluster sampling. Read More

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http://dx.doi.org/10.1186/s13104-018-3998-xDOI Listing
December 2018

Role of HIF-1α in Alcohol-Mediated Multiple Organ Dysfunction.

Biomolecules 2018 Dec 10;8(4). Epub 2018 Dec 10.

Division of Pulmonary, Allergy, Critical Care and Sleep Medicine, Department of Medicine, Emory University, Atlanta, GA 30322, USA.

Excess alcohol consumption is a global crisis contributing to over 3 million alcohol-related deaths per year worldwide and economic costs exceeding $200 billion dollars, which include productivity losses, healthcare, and other effects (e.g., property damages). Read More

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http://www.mdpi.com/2218-273X/8/4/170
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http://dx.doi.org/10.3390/biom8040170DOI Listing
December 2018
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Relapsing Evans syndrome and systemic lupus erythematosus with antiphospholipid syndrome treated with Bortezomib in combination with plasma exchange.

Clin Immunol 2018 Dec 10. Epub 2018 Dec 10.

Laboratory of the Mosaics of Autoimmunity, Saint-Petersburg University, 7/9 Universitetskaya Emb., Saint- Petersburg 199034, Russia.

Relapsing Evans syndrome (ES) and systemic lupus erythematosus (SLE) with secondary antiphospholipid syndrome (APS) is very rare association. Coexistence of these syndromes is potentially fatal and require high-dose combined immunosuppressive therapy. We describe a case of successful use of Bortezomib and plasma exchange in a patient with ES and APS refractory to standard therapy. Read More

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http://dx.doi.org/10.1016/j.clim.2018.12.010DOI Listing
December 2018

Integration of Buprenorphine Treatment with Primary Care: Comparative Effectiveness on Retention, Utilization, and Cost.

Popul Health Manag 2018 Dec 13. Epub 2018 Dec 13.

3 Department of Medicine, Johns Hopkins Bayview Medical Center, Baltimore, Maryland.

Opioid use disorder (OUD) is a national crisis. Health care must achieve greater success than it has to date in helping opioid users achieve recovery. Integration of comprehensive primary care with treatment for OUD has the potential to increase care access among the substance-using population, improve outcomes, and reduce costs. Read More

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http://dx.doi.org/10.1089/pop.2018.0163DOI Listing
December 2018

Construction of High-Density Genetic Maps and Detection of QTLs Associated With Huanglongbing Tolerance in Citrus.

Front Plant Sci 2018 27;9:1694. Epub 2018 Nov 27.

Citrus Research and Education Center, Institute of Food and Agricultural Sciences, University of Florida, Lake Alfred, FL, United States.

Huanglongbing (HLB), or citrus greening, is the most devastating disease in citrus worldwide. Commercial citrus varieties including sweet orange () are highly susceptible to HLB, and trifoliate orange (, a close relative) is widely considered resistant or highly tolerant to HLB. In this study, an intergeneric F population of sweet orange and trifoliate orange was genotyped by Genotyping-by-Sequencing, and high-density SNP-based genetic maps were constructed separately for trifoliate orange and sweet orange. Read More

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http://dx.doi.org/10.3389/fpls.2018.01694DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6278636PMC
November 2018
3.637 Impact Factor

Efficiency or compensation? The global economic crisis and the development of the European Union's social policy.

Glob Soc Policy 2018 Dec 30;18(3):304-322. Epub 2018 Jul 30.

University of Münster, Germany.

How has the global social policy agenda evolved since the global economic crisis? To shed light on this question, this article looks at the discourses in European Union (EU) social policy. It draws on two rival theoretical approaches from the literature on globalisation and the welfare state, the efficiency and compensation hypotheses, and links these approaches to two fundamental rationales underlying the discourse in EU social policy. Based on an analysis of key documents from two Open Methods of Coordination (OMCs), the article shows that the logic underlying the efficiency hypothesis can be extended to discourses in EU social policy. Read More

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http://dx.doi.org/10.1177/1468018118790957DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6236586PMC
December 2018

More or less diverse: An assessment of the effect of attention to media salient company types on media agenda diversity in Dutch newspaper coverage between 2007 and 2013.

Journalism (Lond) 2018 Nov 30;19(11):1608-1627. Epub 2016 Nov 30.

University of Amsterdam, The Netherlands.

This study on news coverage of highly visible company types in a Dutch daily quality newspaper (; N = 14,363), during the economic crisis (2007-2013), shows that attention to banks (and to a lesser extent also to the automobile and components industry) had a structural negative influence on media agenda diversity. The majority of the other salient company types had a significant positive impact on diversity. These results suggest that banks attracted attention at the expense of more varied, diverse coverage during the crisis. Read More

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http://dx.doi.org/10.1177/1464884916680371DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6238172PMC
November 2018

Media representation of the antimicrobial resistance (AMR) crisis: An Australian perspective.

Infect Dis Health 2018 Oct 20. Epub 2018 Oct 20.

Deakin University, Alfred Deakin Research Institute for Citizenship and Globalisation, Australia.

Background: Antimicrobial resistance and the rise of 'super bugs' has become a major threat to public health worldwide, with authorities warning of an 'apocalyptic future' unless addressed as a matter of urgency. Mass circulation media has traditionally taken an active role in informing the public of important public health issues and the measures needed to address these. The key objective of the larger project informing this article was to describe Australian media representations of the AMR crisis and its role in informing the public about the AMR crisis. Read More

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http://dx.doi.org/10.1016/j.idh.2018.09.084DOI Listing
October 2018