J Rheumatol 2017 Feb 15. Epub 2017 Feb 15.
From the Royal National Hospital for Rheumatic Diseases, Royal United Hospitals Foundation Trust; University of Bath, Bath; University College London (UCL) Institute of Child Health; Arthritis Research UK Centre for Adolescent Rheumatology at UCL, University College London Hospitals (UCLH), and Great Ormond Street Hospital (GOSH), London; Leeds Children's Hospital, Leeds; Nottingham University Hospitals UK National Health Service (NHS) Trust, Nottingham, UK. Funding for the UK Juvenile Dermatomyositis Cohort and Biomarker study has been provided by the Wellcome Trust UK (085860), Action Medical Research UK (SP4252), The Myositis Support Group UK, Arthritis Research UK (14518, 20164), The Henry Smith Charity and Great Ormond Street Children's Charity (V1268), and the National Institute for Health Research (NIHR) Translational Research Collaboration Rare Diseases. This research was supported by the NIHR Biomedical Research Centre at GOSH for Children NHS Foundation Trust and Institute of Child Health UCL. SLT is supported by a fellowship from The Bath Institute for Rheumatic Diseases and has received previous support from the BMA Doris Hillier Grant (2012). S.L. Tansley, MBChB, MRCP, Royal National Hospital for Rheumatic Diseases, Royal United Hospitals Foundation Trust, and University of Bath; Z.E. Betteridge, BSc, PhD, University of Bath; S. Simou, MSc, UCL Institute of Child Health; T.S. Jacques, PhD, MRCP, FRCPath, UCL Institute of Child Health, and GOSH; C. Pilkington, MBBS, FRCPCH, FRCP, GOSH; M. Wood, MBBS, MRCPCH, Leeds Children's Hospital; K. Warrier, MBBS, MRCPCH, Nottingham University Hospitals NHS Trust; L.R. Wedderburn, MD, PhD, FRCP, UCL Institute of Child Health, and GOSH, and Arthritis Research UK Centre for Adolescent Rheumatology at UCL, UCLH, and GOSH; N.J. McHugh, MD, FRCP, FRCPath, Royal National Hospital for Rheumatic Diseases, Royal United Hospitals Foundation Trust, and University of Bath. Address correspondence to Dr. S.L. Tansley, Royal National Hospital For Rheumatic Diseases NHS Foundation Trust, Upper Borough Walls, Bath BA1 1RL, UK. E-mail: Accepted for publication December 23, 2016.
: We aimed to establish the prevalence and clinical associations of anti-HMG-CoA-reductase (anti-HMGCR) in a large UK cohort with juvenile myositis.Methods
: There were 381 patients investigated for anti-HMGCR using ELISA.Results
: Anti-HMGCR autoantibodies were detected in 4 patients (1%). Read More