71,883 results match your criteria Myoclonic Epilepsy Beginning in Infancy or Early Childhood

Changes in subdomains of non-organized physical activity between childhood and adolescence in Australia: a longitudinal study.

Int J Behav Nutr Phys Act 2022 Jun 25;19(1):73. Epub 2022 Jun 25.

Early Start, University of Wollongong, Wollongong, NSW, Australia.

Background: Physical activity (PA) participation among youth tends to be insufficient and is prone to decline with age. In Australia, this decline has been shown to particularly occur in the domain of non-organized PA (e.g. Read More

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Identification of a novel splicing mutation and genotype-phenotype correlations in rare PLS3-related childhood-onset osteoporosis.

Orphanet J Rare Dis 2022 Jun 25;17(1):247. Epub 2022 Jun 25.

Division of Spine Surgery, Department of Orthopedic Surgery, Nanjing Drum Tower Hospital, The Affiliated Hospital of Nanjing University Medical School, Nanjing, China.

Background: X-linked early-onset osteoporosis, caused by mutations in plastin3 (PLS3), is an extremely rare disease characterized by low bone mineral density (BMD) and recurrent osteoporotic fractures. There is limited information on genetic and phenotypic spectrum, as well as genotype-phenotype correlations of the disease. Moreover, whether decreased PLS3 levels were also involved in osteoporosis among subjects without PLS3 pathogenic mutations remains unknown. Read More

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Associations of sleep characteristics with cognitive and gross motor development in toddlers.

Sleep Health 2022 Jun 22:704. Epub 2022 Jun 22.

Research Centre in Physical Activity, Health and Leisure, University of Porto, Porto, Portugal; Laboratory for Integrative and Translational Research in Population Health, Porto, Portugal; Directorate-General of Health, National Physical Activity Promotion Program, Portugal.

Objective: To examine cross-sectional associations of sleep characteristics (duration, consolidation, timing, variability) with cognitive and gross motor development in toddlers.

Methods: Participants were 205 toddlers (19.6 ± 4. Read More

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Growing up with clitoromegaly: experiences of North American women with congenital adrenal hyperplasia.

J Pediatr Urol 2022 May 30. Epub 2022 May 30.

Division of Adolescent Medicine, Department of Pediatrics, Indiana University School of Medicine and Department of Sociology, Indiana University Purdue University Indianapolis, Indianapolis, IN, USA.

Introduction: To describe experiences of clitoromegaly in women with congenital adrenal hyperplasia (CAH).

Methods: CAH females (46XX, ≥16 years old) from the United States and Canada were eligible for a cross-sectional online survey (2019-2020) if reporting clitoromegaly (life-long: "growing up with a larger than average clitoris," secondary: "clitoris grew over weeks or months"). A multidisciplinary team and women with CAH drafted questions assessing net effects of clitoromegaly on 10 activities and 10 life domains. Read More

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Molecular mechanism of ethylparaben on zebrafish embryo cardiotoxicity based on transcriptome analyses.

Sci Total Environ 2022 Jun 22:156785. Epub 2022 Jun 22.

Institute of Reproductive Health, Tongji Medical College, Huazhong University of Science and Technology, Wuhan 430030, People's Republic of China. Electronic address:

Ethylparaben (EP), one of the parabens, a ubiquitous food and cosmetic preservatives, has caused widespread concern due to its health risks. Recently, studies have found that parabens exposure during pregnancy is negatively correlated with fetal and early childhood development. However, studies about EP on embryo development are few. Read More

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The interaction of P11 methylation and early-life stress impacts the antidepressant response in patients with major depressive disorder.

J Affect Disord 2022 Jun 22. Epub 2022 Jun 22.

Department of Psychosomatics and Psychiatry, Zhongda Hospital, School of Medicine, Southeast University, Nanjing 210009, PR China; Jiangsu Provincial Key Laboratory of Critical Care Medicine, Southeast university, Nanjing 210009, PR China. Electronic address:

Purpose: The present research investigates the influence of P11 gene DNA methylation combined with life stress on the response to antidepressants in the first two weeks.

Methods: A total of 291 Han Chinese patients with major depressive disorder and 100 healthy controls were included. The Life Events Scale and the Childhood Trauma Questionnaire were used to assess stress. Read More

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Stuttering interventions for children, adolescents, and adults: a systematic review as a part of clinical guidelines.

J Commun Disord 2022 Jun 16;99:106242. Epub 2022 Jun 16.

Finnish Association of Speech and Language Therapists; Private Practice. Electronic address:

Introduction: Stuttering may have a holistic effect on the quality of life of a person who stutters by limiting participation in social situations, resulting in feelings of isolation and frustration, leading to difficulties in education and employment and increasing the likelihood of mental health problems. Even young children who stutter may have negative experiences of speaking. Therefore, it is important to treat stuttering behavior effectively in both children and adults. Read More

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Comparative real-time PCR quantification of cytomegalovirus in severe early childhood caries and caries-free children.

Eur Arch Paediatr Dent 2022 Jun 25. Epub 2022 Jun 25.

Department of Bacteriology and Virology, Medical School, Isfahan University of Medical Sciences, Isfahan, Iran.

Purpose: The present study was undertaken to evaluate cytomegalovirus (CMV) load in carious lesions in children with severe early childhood caries (S-ECC) and compare it with caries-free (CF), healthy children, by quantitative real-time polymerase chain reaction (PCR).

Materials And Methods: Dental plaque samples were collected from 57 subjects including S-ECC (n = 33) and CF (n = 24) patients. The two groups were matched in terms of age, gender, and socioeconomic status. Read More

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Uncombable hair syndrome and beyond.

Acta Dermatovenerol Alp Pannonica Adriat 2022 Jun;31(2):49-64

Department of Molecular Medicine, Princess Al-Jawhara Center for Molecular Medicine and Inherited Disorders, Arabian Gulf University, Manama, Kingdom of Bahrain.

Uncombable hair syndrome presents with frizzy hair in early childhood. Isolated hair manifestations are usually observed; however, systemic involvement of the nervous system, eyes, and ears have also been reported. The syndrome has been classified into three subtypes, correlating with the three mutated genes: peptidyl arginine deiminase, type III; transglutaminase 3; and trichohyalin. Read More

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Seasonal influenza vaccination expands hemagglutinin-specific antibody breadth to older and future A/H3N2 viruses.

NPJ Vaccines 2022 Jun 24;7(1):67. Epub 2022 Jun 24.

Influenza Centre, Department of Clinical Science, University of Bergen, Bergen, Norway.

History of influenza A/H3N2 exposure, especially childhood infection, shape antibody responses after influenza vaccination and infection, but have not been extensively studied. We investigated the breadth and durability of influenza A/H3N2-specific hemagglutinin-inhibition antibodies after live-attenuated influenza vaccine in children (aged 3-17 years, n = 42), and after inactivated influenza vaccine or infection in adults (aged 22-61 years, n = 42) using 14 antigenically distinct A/H3N2 viruses circulating from 1968 to 2018. We found that vaccination and infection elicited cross-reactive antibody responses, predominantly directed against newer or future strains. Read More

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Low level lead exposure in early childhood and parental education on adolescent IQ and working memory: a cohort study.

J Expo Sci Environ Epidemiol 2022 Jun 24. Epub 2022 Jun 24.

School of Nursing, University of Pennsylvania, 418 Curie Blvd. Claire M. Fagin Hall, Philadelphia, PA, USA.

Background: The independent effect of lead exposure and parental education on children's neurocognition is well-documented. However, few studies have examined the combined effect of childhood lead exposure and parental education on adolescent neurocognition, especially in China.

Objective: Examine both the combined and interactive effect of childhood blood lead levels (BLLs) and parental education on early adolescent neurocognition. Read More

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Does artistic activity help kids avoid obesity? Emergent considerations in the ecology of childhood BMI.

Prev Med 2022 Jun 21:107120. Epub 2022 Jun 21.

Department of Educational Foundations, Organizations, and Policy, University of Pittsburgh, PA, USA.

Although the positive relationship between arts engagement and mental health is well documented, arts participation may be an emergent factor in the ecology of childhood obesity. Prior research hypothesized several potential health benefits of arts participation including healthy diet and lifestyles, but the available evidence is mainly limited to cross-sectional covariate-adjustment models for the adult population. We employed a newly released panel of the Early Childhood Longitudinal Study kindergarten cohort (ECLS-K: 2011), which is a nationally representative sample of American children who entered kindergarten in 2010-2011 (n = 15,820). Read More

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The interaction between infant negative emotionality and cognition predicts ADHD-related behaviors in toddlerhood.

Infant Behav Dev 2022 Jun 21;68:101742. Epub 2022 Jun 21.

Department of Psychiatry, University of Pittsburgh, Pittsburgh, PA, USA.

Attention-deficit/hyperactivity disorder (ADHD) is a highly prevalent disorder commonly identified in childhood. Affective and cognitive characteristics that are identifiable as early as infancy could be signals of risk for developing ADHD. Specifically, the interplay between emotionality and cognition may be important in predicting early symptoms of ADHD. Read More

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Defining Essential Childhood Cancer Medicines to Inform Prioritization and Access: Results From an International, Cross-Sectional Survey.

JCO Glob Oncol 2022 Jun;8:e2200034

Division of Cancer Care and Epidemiology, Queen's University Cancer Research Institute, Kingston, Canada.

Purpose: Access to essential cancer medicines is a major determinant of childhood cancer outcomes globally. The degree to which pediatric oncologists deem medicines listed on WHO's Model List of Essential Medicines for Children (EMLc) essential is unknown, as is the extent to which such medicines are accessible on the front lines of clinical care.

Methods: An electronic survey developed was distributed through the International Society of Pediatric Oncology mailing list to members from 87 countries. Read More

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Theory of planned behavior explains males' and females' intention to receive COVID-19 vaccines differently.

Hum Vaccin Immunother 2022 Jun 24:2086393. Epub 2022 Jun 24.

Department of Early Childhood Education, The Education University of Hong Kong, Hong Kong S.A.R., China.

Uptake of COVID-19 vaccines is an important measure to curb the transmission of the coronavirus. Before the vaccines were available, numerous studies found that people had a moderate-to-high intention to receive the vaccines. Several studies have also used the theory of planned behavior (TPB) to predict people's COVID-19 vaccination intention with three elements (i. Read More

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Effects of long-term childhood exercise and detraining on lipid accumulation in metabolic-related organs.

PLoS One 2022 24;17(6):e0270330. Epub 2022 Jun 24.

Department of Musculoskeletal Functional Research and Regeneration, Graduate School of Biomedicine and Health Sciences, Hiroshima University, Kasumi, Minami-ku, Hiroshima, Japan.

The preventive effects of regular exercise on obesity-related health problems are carried over to the non-exercise detraining period, even when physical activity decreases with aging. However, it remains unknown whether regular childhood exercises can be carried over to adulthood. Therefore, this study aimed to investigate the effects of long-term childhood exercise and detraining on lipid accumulation in organs to prevent obesity in adulthood. Read More

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Cultures Crossing: The Power of Habit in Delaying Gratification.

Psychol Sci 2022 Jun 24:9567976221074650. Epub 2022 Jun 24.

Department of Psychology University of California, Davis.

Resisting immediate temptations in favor of larger later rewards predicts academic success, socioemotional competence, and health. These links with delaying gratification appear from early childhood and have been explained by cognitive and social factors that help override tendencies toward immediate gratification. However, some tendencies may actually promote delaying gratification. Read More

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Cd59 and inflammation regulate Schwann cell development.

Elife 2022 Jun 24;11. Epub 2022 Jun 24.

Neuroscience Graduate Program, University of Virginia, Charlottesville, United States.

Efficient neurotransmission is essential for organism survival and is enhanced by myelination. However, the genes that regulate myelin and myelinating glial cell development have not been fully characterized. Data from our lab and others demonstrates that , which encodes for a small GPI-anchored glycoprotein, is highly expressed in developing zebrafish, rodent, and human oligodendrocytes (OLs) and Schwann cells (SCs), and that patients with CD59 dysfunction develop neurological dysfunction during early childhood. Read More

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Observed shyness leads to more automatic imitation in early childhood.

Dev Psychobiol 2022 Sep;64(6):e22272

Department of Psychology, Neuroscience, and Behaviour, McMaster University, Hamilton, Ontario, Canada.

The authors investigated children's automatic imitation in the context of observed shyness by adapting the widely used automatic imitation task (AIT). AIT performance in 6-year-old children (N = 38; 22 female; 71% White) and young adults (17-22 years; N = 122; 99 female; 32% White) was first examined as a proof of concept and to assess age-related differences in responses to the task (Experiment 1). Although error rate measures of automatic imitation were comparable between children and adults, children displayed less reaction time interference than adults. Read More

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September 2022

Community-based Interventions to Prevent Dental Caries among Kindergarten Children in Vietnam: A 12-month Study of Field Trial.

J Contemp Dent Pract 2022 Feb 1;23(2):135-142. Epub 2022 Feb 1.

Institute for Community Health Research, University of Medicine and Pharmacy, Hue University, Hue City, Vietnam; Faculty of Public Health, University of Medicine and Pharmacy, Hue University, Hue City, Vietnam, e-mail:

Aim: To investigate the status of dental caries and assess the effectiveness of dental caries prevention interventions in children from 3 to 5-year-old in Hue City, Vietnam.

Materials And Methods: The subjects were 464 children and their direct caregivers at some kindergartens in Hue City from June 2020 to October 2021. The study included two consecutive phases: the first one was a cross-sectional study to identify the rate of dental caries and related factors in the studied kindergartens, and phase 2 was a controlled comparative interventional study for a period of 12 months. Read More

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February 2022

Cord blood leptin level and a common variant of its receptor as determinants of the BMI trajectory: The EDEN mother-child cohort.

Pediatr Obes 2022 Jun 23:e12955. Epub 2022 Jun 23.

Centre for Research in Epidemiology and StatisticS, Université de Paris-cité, INSERM, INRAE, Paris, France.

Background: Cord blood leptin is an indicator of neonatal fat mass and could shape postnatal adiposity trajectories. Investigating genetic polymorphisms of the leptin receptor gene (LEPR) could help understand the mechanisms involved.

Objectives: We aimed to investigate the association of cord blood leptin level and the LEPR rs9436303 polymorphism, with body mass index (BMI) at adiposity peak (AP) and age at adiposity rebound (AR). Read More

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What Have We Learned About the Genetics of Obsessive-Compulsive and Related Disorders in Recent Years?

Focus (Am Psychiatr Publ) 2021 Oct 5;19(4):384-391. Epub 2021 Nov 5.

Department of Biomedicine, Aarhus University, Aarhus, Denmark (Mattheisen); Department of Psychiatry, Robert Wood Johnson Medical School and New Jersey Medical School, Rutgers University, Newark (M. Pato, C. Pato); Department of Cell Biology, SUNY Downstate Health Sciences University, Brooklyn, New York (Knowles).

Obsessive-compulsive disorder (OCD) is a complex, multifactorial disorder with onset in either childhood or early adulthood. Lifetime prevalence has been estimated to be around 2%-3%. groups OCD together with closely related disorders-body dysmorphic disorder, trichotillomania (hair-pulling disorder), hoarding disorder, and excoriation disorder (skin-picking disorder)-as obsessive-compulsive and related disorders (OCRDs). Read More

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October 2021

Lung function in young adulthood: differences between males and females with asthma.

ERJ Open Res 2022 Apr 20;8(2). Epub 2022 Jun 20.

Dept of Clinical Science and Education, Södersjukhuset, Karolinska Institute, Stockholm, Sweden.

Background: There are phenotypic differences in asthma in males and females. Differences in lung function between the sexes at the peak lung function level in young adulthood are so far not directly addressed. The aim of the present study was to assess lung function in early adulthood in males and females depending on asthma onset and remission. Read More

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Effect of early two-dose measles vaccination on childhood mortality and modification by maternal measles antibody in Guinea-Bissau, West Africa: A single-centre open-label randomised controlled trial.

EClinicalMedicine 2022 Jul 27;49:101467. Epub 2022 May 27.

Bandim Health Project, Indepth Network, Apartado 861, Bissau, Guinea-Bissau.

Background: Early 2-dose measles vaccine (MV) at 4 and 9 months of age vs. the WHO strategy of MV at 9 months of age reduced all-cause child mortality in a previous trial. We aimed to test two hypotheses: 1) a 2-dose strategy reduces child mortality between 4 and 60 months of age by 30%; 2) receiving early MV at 4 months in the presence versus absence of maternal measles antibodies (MatAb) reduces child mortality by 35%. Read More

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Torque Teno Virus Primary Infection Kinetics in Early Childhood.

Viruses 2022 Jun 11;14(6). Epub 2022 Jun 11.

Department of Virology, University of Helsinki, 00290 Helsinki, Finland.

Human torque teno viruses (TTVs) are a diverse group of small nonenveloped viruses with circular, single-stranded DNA genomes. These elusive anelloviruses are harbored in the blood stream of most humans and have thus been considered part of the normal flora. Whether the primary infection as a rule take(s) place before or after birth has been debated. Read More

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Biomarkers Predictive of Metabolic Syndrome and Cardiovascular Disease in Childhood Cancer Survivors.

J Pers Med 2022 May 27;12(6). Epub 2022 May 27.

Pediatric Oncology Unit, Fondazione Policlinico Universitario A. Gemelli IRCCS, Università Cattolica Sacro Cuore, 00168 Rome, Italy.

The improvement in childhood cancer treatments resulted in a marked improvement in the survival of pediatric cancer patients. However, as survival increased, it was also possible to observe the long-term side effects of cancer therapies. Among these, metabolic syndrome is one of the most frequent long-term side effects, and causes high mortality and morbidity. Read More

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Vascular Alterations Preceding Arterial Wall Thickening in Overweight and Obese Children.

J Clin Med 2022 Jun 19;11(12). Epub 2022 Jun 19.

Division of Cardiology, Department of Internal Medicine, Hallym Sacred Heart Hospital, Hallym University College of Medicine, Anyang 14068, Korea.

Background: Childhood obesity is linked to adverse cardiovascular outcomes in adulthood. This study aimed to assess the impact of childhood obesity on the vasculature and to investigate whether vascular alteration precedes arterial wall thickening in childhood.

Methods: A total of 295 overweight (body mass index [BMI] 85th to 95th percentile, = 30) and obese (BMI ≥ 95th percentile, = 234) children aged 7-17 years and 31 normal-weight controls with similar age and gender were prospectively recruited. Read More

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Prophylactic Hydroxyurea Treatment Is Associated with Improved Cerebral Hemodynamics as a Surrogate Marker of Stroke Risk in Sickle Cell Disease: A Retrospective Comparative Analysis.

J Clin Med 2022 Jun 17;11(12). Epub 2022 Jun 17.

Clinical Research Institute, College of Medicine, Central Michigan University, 1280 S. East Campus Dr., Mount Pleasant, MI 48859, USA.

Sickle cell disease (SCD) increases the incidence of childhood stroke eighty-fold. Stroke risk can be estimated by measurement of the blood velocity through the middle cerebral artery (MCA) using transcranial doppler ultrasound (TCD). A high MCA blood velocity indicates increased stroke risk due to cerebral vasculopathy, and first-line treatment to prevent primary or recurrent strokes in high-risk children with SCD has classically been chronic blood transfusions. Read More

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White Matter Correlates of Early-Onset Bipolar Illness and Predictors of One-Year Recurrence of Depression in Adults with Bipolar Disorder.

J Clin Med 2022 Jun 15;11(12). Epub 2022 Jun 15.

Department of Psychiatry, University of Pittsburgh, Pittsburgh, PA 15260, USA.

Diffusion Magnetic Resonance Imaging (dMRI) studies have reported abnormalities in emotion regulation circuits in BD; however, no study has examined the contribution of previous illness on these mechanisms. Using global probabilistic tractography, we aimed to identify neural correlates of previous BD illness and the extent to which these can help predict one-year recurrence of depressive episodes. dMRI data were collected in 70 adults with early-onset BD who were clinically followed for up to 18 years and 39 healthy controls. Read More

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Exposure to Childhood Healthcare Discrimination and Healthcare Avoidance among Transgender and Gender Independent Adults during a Global Pandemic.

Int J Environ Res Public Health 2022 Jun 17;19(12). Epub 2022 Jun 17.

Health Psychology, Department of Psychology, Virginia Commonwealth University, Richmond, VA 23284, USA.

Transgender and gender-independent individuals (TGI) encounter myriad barriers to accessing affirming healthcare. Healthcare discrimination and erasure exposure among TGI individuals is vital to understanding healthcare accessibility, utilization behaviors, and health disparities in this population. Exposure to gender identity-related healthcare discrimination and erasure in childhood may contribute to TGI adults' healthcare utilization behaviors. Read More

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