66,060 results match your criteria Myoclonic Epilepsy Beginning in Infancy or Early Childhood

Maternal social support, depression and emotional availability in early mother-infant interaction: Findings from a pregnancy cohort.

J Affect Disord 2021 May 27;292:757-765. Epub 2021 May 27.

School of Medicine, University of Notre Dame, Fremantle, Australia; Psychology, Murdoch University, Perth, Australia; Women's Health, Genetics and Mental Health Directorate, King Edward Memorial Hospital for Women, Subiaco, Australia; Faculty of Health and Medicine Sciences, University of Western Australia, Perth, Australia. Electronic address:

Background: Social support theory suggests that parental social support may influence the nature of early parenting behaviours and specifically the mother-infant relationship. This study examines whether support from a partner, friends or family is associated with differences in quality of mother-infant interactions in the context of maternal depression.

Methods: 210 women were followed from early pregnancy to six months postpartum within Australian pregnancy cohort, the Mercy Pregnancy and Emotional Wellbeing Study (MPEWS). Read More

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I'm a mother, therefore I question": Parents' legitimation sources of and hesitancy towards early childhood vaccination.

Soc Sci Med 2021 Jun 13;282:114132. Epub 2021 Jun 13.

Lokman Hekim University School of Medicine, Department of Public Health, Söğütözü Mh. 2179 Cd. No: 6, Çankaya, Ankara, Turkey. Electronic address:

This study was conducted with mothers living in Ankara and registered in the year 2019 with the Immunization Services Unit of the Provincial Directorate of Health as cases of vaccine refusal. This qualitative study used semi-structured interviews to understand how mothers decide about child vaccination and the attitudes, perceptions, and beliefs underlying these decisions. A total of 23 interviews were conducted by two of the authors between March and September 2019. Read More

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The association of prenatal vitamin D sufficiency with aeroallergen sensitization and allergic rhinitis in early childhood.

J Allergy Clin Immunol Pract 2021 Jun 21. Epub 2021 Jun 21.

Channing Division of Network Medicine, Brigham and Women's Hospital and Harvard Medical School, Boston, MA, USA; Division of Allergy and Clinical Immunology, Brigham and Women's Hospital and Harvard Medical School, Boston, MA, USA.

Background: The role of prenatal vitamin D sufficiency and supplementation in the development of childhood aeroallergen sensitization and allergic rhinitis remains uncertain.

Objective: To describe the association of prenatal vitamin D sufficiency with childhood allergic outcomes in participants of the Vitamin D Antenatal Asthma Reduction Trial (VDAART), a randomized controlled trial of prenatal vitamin D supplementation.

Methods: 414 mother-offspring pairs with offspring aeroallergen sensitization data available at 6 years of age were included in this analysis. Read More

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A short-sighted approach to high myopia-not just an eye problem.

J AAPOS 2021 Jun 21. Epub 2021 Jun 21.

Princess Alexandra Eye Pavilion, Edinburgh.

We present the first case of rapid onset high myopia in early childhood as the presenting feature of Loeys-Dietz syndrome. The patient progressed from a normal degree of hyperopia (+2 diopter sphere [DS]) at 18 months of age to high myopia (-10 DS) 9 months later. Subsequent genetic testing revealed both her brothers and her father to carry the same TGFB3 pathogenic variant. Read More

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Juvenile Paget's Disease: report of a successful treatment throughout the complete growth of a patient with a missense TNFRSF11B mutation.

Joint Bone Spine 2021 Jun 21:105243. Epub 2021 Jun 21.

Pediatric Rheumatology Unit, Hospital Pediátrico, Centro Hospitalar e Universitário de Coimbra, Avenida Afonso Romão, 3000-602 Coimbra, Portugal.

Introduction: Juvenile Paget's Disease (JPD) is an ultra-rare inherited osteopathy featuring markedly accelerated bone turnover. Several clinical characteristics have been reported, including bone deformities developing in childhood and hearing loss.

Case Report: We report the case of a 2 ¾-year-old girl that presented with progressive bowing of both legs since the age of 2, lower limb pain and frequent falls with one consequent femur fracture. Read More

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Trajectories of Adiposity Indicators and Association with Asthma and Lung Function in Urban Minority Children.

J Allergy Clin Immunol 2021 Jun 21. Epub 2021 Jun 21.

Division of Pediatric Pulmonology, Columbia University Irving Medical Center, Vagelos College of Physicians and Surgeons, New York, NY.

Background: A relationship between adiposity and asthma has been described in some cohort studies, yet little is known about trajectories of adiposity throughout early childhood among children at high-risk for developing asthma in urban United States cities. Moreover, early life trajectories of adipokines that have metabolic and immunologic properties have not been comprehensively investigated.

Objective: Our objective was to characterize trajectories of adiposity in a longitudinal birth cohort of predominately Black and Latinx children (n=418) using several different repeated measures including body mass index (BMI) z-score, bio-impedance analysis (BIA), leptin and adiponectin in the first 10 years of life. Read More

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Parenthood among men diagnosed with cancer in childhood and early adulthood: trends over time in a Danish national cohort.

Hum Reprod 2021 Jun 24. Epub 2021 Jun 24.

The Fertility Department, Copenhagen University Hospital, Rigshospitalet, Copenhagen, Denmark.

Study Question: Is the rate of fatherhood among men diagnosed with cancer in childhood and early adulthood different from men without cancer, and, if so, have the differences changed over time?

Summary Answer: Men diagnosed with cancer have had significantly reduced rates of fatherhood compared with undiagnosed men; however, the rates of fatherhood among the cancer survivors have increased markedly over time.

What Is Known Already: The number of children and young adolescents who survive cancer has steadily increased over recent decades, with a current 5-year survival rate of approximately 80%. Consequently, life circumstances after cancer have gained increasing importance, including the desire among survivors to have children and a family. Read More

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Remote and adjacent psychological predictors of early-adulthood resilience: Role of early-life trauma, extraversion, life-events, depression, and social-support.

PLoS One 2021 24;16(6):e0251859. Epub 2021 Jun 24.

Department of Nursing Psychology, Army Medical University, Chongqing, China.

Resilience is important for people to maintain mental health after negative life-events. However, its longitudinal psychological and social predictors are poorly revealed. Based on the ecological system theory model, the current study aimed to determine the longitudinal temporal mechanism underlying the development of early-adulthood resilience using long-term (early-life trauma and personality), medium-term and short-term (life-events, social support, and depression) psychosocial predictors. Read More

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Exposure to traffic-related air pollution and bacterial diversity in the lower respiratory tract of children.

PLoS One 2021 24;16(6):e0244341. Epub 2021 Jun 24.

Department of Environmental Health, University of Cincinnati, Cincinnati, OH, United States of America.

Background: Exposure to particulate matter has been shown to increase the adhesion of bacteria to human airway epithelial cells. However, the impact of traffic-related air pollution (TRAP) on the respiratory microbiome is unknown.

Methods: Forty children were recruited through the Cincinnati Childhood Allergy and Air Pollution Study, a longitudinal cohort followed from birth through early adolescence. Read More

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Germline RUNX1 variation and predisposition to childhood acute lymphoblastic leukemia.

J Clin Invest 2021 Jun 24. Epub 2021 Jun 24.

Department of Pharmaceutical Sciences, St. Jude Children's Research Hospital, Memphis, United States of America.

Genetic alterations in the RUNX1 gene are associated with benign and malignant blood disorders, particularly of megakaryocyte and myeloid lineages. The role of RUNX1 in acute lymphoblastic leukemia (ALL) is less clear, particularly how germline genetic variation influences the predisposition to this type of leukemia. Sequencing 4,836 children with B-ALL and 1,354 cases of T-ALL, we identified 31 and 18 germline RUNX1 variants, respectively. Read More

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Adverse childhood experiences and somatic symptoms in adulthood: A moderated mediation effects of disturbed self-organization and resilient coping.

Psychol Trauma 2021 Jun 24. Epub 2021 Jun 24.

Faculty of Arts.

Objective: Early life adversity is associated with somatic symptoms (SS) in adulthood, but the psychological mechanisms involved need to be further investigated. The aim of this study was to investigate whether disturbances in self-organization (DSO), consisting of affective dysregulation, negative self-concept, and disturbances in relationships, mediate the relationship between exposure to adverse childhood experiences (ACEs) and SS in adulthood. In addition, we investigated whether resilient coping buffers the direct and indirect effect of ACEs on SS. Read More

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Childhood abuse and neglect and self-reported symptoms of psychopathology through midlife.

Dev Psychol 2021 May;57(5):824-836

Institute of Child Development, University of Minnesota.

Although abuse and neglect in the early years of life have been reliably linked to poor mental health outcomes in childhood, only a few studies have examined whether the predictive significance of childhood abuse and neglect endures for symptoms of psychopathology into adulthood. Here we examined to what extent prospectively assessed child abuse and neglect is associated with self-reported symptoms of psychopathology measured from ages 23 through 39 years, controlling for early demographic covariates and self-reported symptoms of psychopathology measured at age 16 years. The sample included 140 participants from the Minnesota Longitudinal Study of Risk and Adaptation. Read More

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Giving priority to race or wealth in peer group contexts involving social inclusion.

Dev Psychol 2021 May;57(5):651-661

Department of Human Development and Quantitative Methodology, University of Maryland, College Park.

This study investigated children's and adolescents' predictions regarding intergroup inclusion in contexts where peers differed on two dimensions of group membership: race and wealth. African American and European American participants ( = 153; age range: 8-14 years, = 11.46 years) made predictions about whether afterschool clubs would prefer to include a peer based on race or wealth and reported what they personally thought should happen. Read More

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Expanding the phenotypic spectrum of FINCA syndrome beyond infancy.

Clin Genet 2021 Jun 24. Epub 2021 Jun 24.

Dr. von Haunersches Kinderspital, University of Munich, German Center for Lung Research, Munich, Germany.

Background: Fibrosis, neurodegeneration, and cerebral angiomatosis (FINCA, MIM#618278) is a rare clinical condition caused by bi-allelic variants in NHL repeat containing protein 2 (NHLRC2, MIM*618277). Pulmonary disease may be the presenting sign and the few patients reported so far, all deceased in early infancy.

Methods: Exome sequencing was performed on patients with childhood interstitial lung disease (chILD) and additional neurological features. Read More

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An update of the aetiological factors involved in molar incisor hypomineralisation (MIH): a systematic review and meta-analysis.

Eur Arch Paediatr Dent 2021 Jun 24. Epub 2021 Jun 24.

Private Paediatric Dental Clinic, 2 Papadiamantopoulou Street, 11528, Athens, Greece.

Purpose: To systematically review the aetiological factors associated with molar incisor hypomineralisation (MIH). To this day, the aetiology remains unknown. Determining risk factors would allow risk assessment and enhance early diagnosis of MIH in young patients. Read More

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The Development of Disgust and Its Relationship to Adolescent Psychosocial Functioning.

Child Psychiatry Hum Dev 2021 Jun 23. Epub 2021 Jun 23.

Institute for the Study of Child Development, Rutgers Robert Wood Johnson Medical School, New Brunswick, NJ, USA.

Experiences of excessive disgust have been implicated in several psychopathologies. Research, however, has rarely examined disgust and its role in psychosocial functioning from a developmental standpoint. This study examines the relationship between disgust expression in early life and subsequent adolescent psychosocial functioning. Read More

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Preschool Teachers' Technology Acceptance During the COVID-19: An Adapted Technology Acceptance Model.

Front Psychol 2021 7;12:691492. Epub 2021 Jun 7.

Institute of Early Childhood Education, Faculty of Education, Beijing Normal University, Beijing, China.

Online education has become a major reaction to the COVID-19 epidemic, which requires preschool teachers to quickly adapt to online education and accept educational technology. In this emergency background, research on the preschool teachers' technology acceptance provides clues to improve preschool teachers' intention to use educational technology. The Technology Acceptance Model (TAM) is widely used to examine the process of individuals' technology acceptance in the previous literature. Read More

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Initial radiological signs of dentofacial deformity in juvenile idiopathic arthritis.

Sci Rep 2021 Jun 23;11(1):13142. Epub 2021 Jun 23.

Section of Orthodontics, Institute for Oral Health, Aarhus University, Vennelyst Boulevard, 9-11, Aarhus, Denmark.

Juvenile idiopathic arthritis (JIA) is the most common rheumatic disease in childhood and the temporomandibular joint (TMJ) is often involved. TMJ arthritis in growing individuals can cause deformation of facial skeleton (dentofacial deformity) and TMJ components (TMJ deformity). Treatment outcome hinges on early initiation of anti-inflammatory treatment and orthopaedic treatment with dental splints. Read More

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28 years of functioning of the ileal ureter - own experience and systematic review.

J Pediatr Urol 2021 Jun 1. Epub 2021 Jun 1.

Upper Silesian Child Health Center in Katowice, Silesian University of Medicine, Pediatric Surgery and Urological Department, Katowice, Poland.

A Short Introduction: Irreversible ureteral damage is a rare and challenging problem for pediatric urologists. Ileal replacement has become one of the limited surgical options for ureteral reconstruction. Only a few papers have examined the results of the ileal ureter and renal function outcomes. Read More

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Inhaled Corticosteroid Use in Early Childhood: A Risk for High BMI?

Am J Respir Crit Care Med 2021 Jun 23. Epub 2021 Jun 23.

Children's Hospital Boston, Pediatric Allergy and Immunology, Boston, Massachusetts, United States;

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Children with Multiple Endocrine Neoplasia type 2B: not tall and marfanoid, but short with normal body proportions.

Clin Endocrinol (Oxf) 2021 Jun 23. Epub 2021 Jun 23.

Department of Pediatric Endocrinology, Wilhelmina Children's Hospital, University Medical Center Utrecht, 3508, AB, Utrecht, The Netherlands.

Objective: Multiple Endocrine Neoplasia 2B (MEN2B) is characterized by early-onset medullary thyroid carcinoma (MTC), pheochromocytoma and several non-endocrine manifestations. Unfortunately, MEN2B is often diagnosed late, after development of clinically significant MTC. Marfanoid habitus is considered an important related feature, which may lead to the assumption that patients with MEN2B have tall stature. Read More

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The politics of vulnerable masculinity in couple therapy.

J Marital Fam Ther 2021 Jun 23. Epub 2021 Jun 23.

Department of Family Relations and Applied Nutrition, University of Guelph, Guelph, ON, Canada.

Couple therapy and related literature has problematized men's emotional inexpressiveness as constraining for men and as contributing to men's privileged and dominating position vis-à-vis women. Fostering men's emotionality in and outside of therapy has been proposed as a way to improve men's well-being and relationships and promote gender equality. Critical masculinity scholars have noted that many men now enact vulnerable ("softer") and emotional forms of masculinity. Read More

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Gene × Environment Interactions in the Development of Preschool Effortful Control, and Its Implications for Childhood Externalizing Behavior.

Behav Genet 2021 Jun 23. Epub 2021 Jun 23.

University of Oregon, Eugene, USA.

This study examined the role of gene × environment interaction (G × E) in the development of effortful control (EC) and externalizing symptoms (EXT). Participants included 361 adopted children, and their Adoptive Parents (APs) and Birth Mothers (BMs), drawn from the Early Growth and Development Study. The primary adoptive caregivers' (AP1) laxness and overreactivity were assessed when children were 27-months-old, and used as indices of environmental influences on EC. Read More

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Exposure to Heavy Metals and Trace Elements and Childhood Blood Pressure in a U.S. Urban, Low-Income, Minority Birth Cohort.

Environ Health Perspect 2021 Jun 23;129(6):67005. Epub 2021 Jun 23.

Department of Epidemiology, Johns Hopkins Bloomberg School of Public Health, Baltimore, Maryland, USA.

Background: exposure to heavy metals lead (Pb), mercury (Hg), and cadmium (Cd) may be associated with higher childhood blood pressure (BP), whereas trace elements selenium (Se) and manganese (Mn) may have protective antioxidant effects that modify metal-BP associations.

Objectives: We examined the individual and joint effects of exposure to Pb, Hg, Cd, Se, and Mn on childhood BP.

Methods: We used data from the Boston Birth Cohort (enrolled 2002-2013). Read More

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Harefuah 2021 Jun;160(6):377-381

Child Health and Sports Center, Meir Medical Center.

Introduction: McArdle disease (Glycogen storage disease type V) is a myopathy caused by an inherited deficit of muscle glycogen phosphorylase (PYGM). Since glycogen is an important fuel for muscular activity, people with McArdle's disease experience exercise intolerance. Dynamic or static vigorous exercise may lead to rhabdomyolysis, myoglobinuria and renal failure. Read More

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Systematic Review of Clinical Practice Guidelines for Oral Health in Children With Cleft Lip and Palate.

Cleft Palate Craniofac J 2021 Jun 23:10556656211025189. Epub 2021 Jun 23.

Strategic Programs and Partnerships, Comprehensive Cleft Care, Smile Train, NY, USA.

Objective: Clinical practice guidelines (CPGs) exist to present recommendations and policies aimed at optimizing the oral health of children and adolescents born with cleft lip and/or palate. The aim of this review is to identify and assess the scope, quality, adequacy, and consistency of CPGs related to oral health in children and adolescents with clefts, along with reporting any differences and shortcomings.

Methods: A systematic review of the literature of CPGs following Preferred Reporting Items for Systematic Reviews guidelines was conducted. Read More

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Obesity, oxidative DNA damage and vitamin D as predictors of genomic instability in children and adolescents.

Int J Obes (Lond) 2021 Jun 22. Epub 2021 Jun 22.

School of Life Sciences, University of Westminster, London, UK.

Background/objectives: Epidemiological evidence indicates obesity in childhood and adolescence to be an independent risk factor for cancer and premature mortality in adulthood. Pathological implications from excess adiposity may begin early in life. Obesity is concurrent with a state of chronic inflammation, a well-known aetiological factor for DNA damage. Read More

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The impact of obesity on left ventricular hypertrophy and diastolic dysfunction in children and adolescents.

Sci Rep 2021 Jun 22;11(1):13022. Epub 2021 Jun 22.

Department of Cardiology, Inselspital, Bern University Hospital, University of Bern, 3010, Bern, Switzerland.

Childhood obesity continues to escalate worldwide and may affect left ventricular (LV) geometry and function. The aim of this study was to investigate the impact of obesity on prevalence of left ventricular hypertrophy (LVH) and diastolic dysfunction in children. In this analysis of prospectively collected cross-sectional data of children between 5 and 16 years of age from randomly selected schools in Peru, parameters of LV geometry and function were compared according to presence or absence of obesity (body mass index z-score > 2). Read More

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Caregivers' estimate of early childhood developmental status in rural Uganda: a cross-sectional study.

BMJ Open 2021 Jun 22;11(6):e044708. Epub 2021 Jun 22.

International Health, Johns Hopkins University Bloomberg School of Public Health, Baltimore, Maryland, USA.

Objective: To characterise developmental milestones among young children living in rural communities in Uganda.

Design: Cross-sectional study.

Setting: Iganga-Mayuge Health and Demographic Surveillance Site in rural eastern Uganda. Read More

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