54,982 results match your criteria Myoclonic Epilepsy Beginning in Infancy or Early Childhood


The Magic of Mechanism to Explanation-Based Instruction on Counterintuitive Concepts in Early Childhood.

Authors:
Deborah Kelemen

Perspect Psychol Sci 2019 Apr 24:1745691619827011. Epub 2019 Apr 24.

Department of Psychological and Brain Sciences, Boston University.

Common-sense intuitions can be useful guides in everyday life and problem solving. However, they can also impede formal science learning and provide the basis for robust scientific misconceptions. Addressing such misconceptions has generally been viewed as the province of secondary schooling. Read More

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http://dx.doi.org/10.1177/1745691619827011DOI Listing

Canadian newcomer children's bone health and vitamin D status.

Appl Physiol Nutr Metab 2019 Apr 24:1-8. Epub 2019 Apr 24.

b College of Pharmacy and Nutrition, University of Saskatchewan, 104 Clinic Place, SK S7N 2Z4, Canada.

Adequate calcium intake and supply of vitamin D during childhood play important roles in ensuring adequate bone mass gain to achieve optimal peak bone mass. The Healthy Immigrant Children study employed a mixed-method cross-sectional study design to characterize the health and nutritional status of 300 immigrant and refugee children aged 3-13 years who had been in Canada for less than 5 years. This paper presents bone mineral content and vitamin D status data along with qualitative data that deepen the understanding of newcomer bone health status. Read More

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http://dx.doi.org/10.1139/apnm-2018-0705DOI Listing
April 2019
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Stiripentol for the treatment of seizures in Dravet syndrome.

Expert Rev Clin Pharmacol 2019 Apr 24:1-10. Epub 2019 Apr 24.

a University of Colorado Denver Anschutz School of Medicine , Children's Hospital Colorado , Aurora , CO , USA.

Introduction: Dravet syndrome is an early childhood-onset epilepsy syndrome characterized by drug-resistant seizures, frequent episodes of status epilepticus, and the development of neurocognitive impairment. Seizure freedom in this condition is rare and there is a higher rate of sudden unexplained death in epilepsy patients (SUDEP) than other epilepsy syndromes. Stiripentol is a recently approved medication with an indication specifically for the treatment of seizures in children with Dravet syndrome. Read More

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http://dx.doi.org/10.1080/17512433.2019.1605904DOI Listing

The relationship between biological and psychosocial risk factors and resting-state functional connectivity in 2-month-old Bangladeshi infants: a feasibility and pilot study.

Dev Sci 2019 Apr 23:e12841. Epub 2019 Apr 23.

Laboratories of Cognitive Neuroscience, Division of Developmental Medicine, Department of Medicine, Boston Children's Hospital, Boston, Massachusetts, U.S.

Childhood poverty has been associated with structural and functional alterations in the developing brain. However, poverty does not alter brain development directly, but acts through associated biological or psychosocial risk factors (e.g. Read More

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http://dx.doi.org/10.1111/desc.12841DOI Listing

Weight trajectories and disordered eating behaviours in 11- to 12-year-olds: A longitudinal study within the Danish National Birth Cohort.

Eur Eat Disord Rev 2019 Apr 23. Epub 2019 Apr 23.

Section of Epidemiology, Department of Public Health, University of Copenhagen, Copenhagen, Denmark.

Objective: To examine how childhood weight trajectories are associated with disordered eating behaviours (DEBs) in early adolescence.

Methods: Self-reports on DEBs (fasting, purging, and binge eating) were obtained from 18,337 children in the 11-year follow-up of the Danish National Birth Cohort. For this population, birth register information on gestational age and birth weight was categorized into the following: small, appropriate, and large for gestational age. Read More

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https://onlinelibrary.wiley.com/doi/abs/10.1002/erv.2680
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http://dx.doi.org/10.1002/erv.2680DOI Listing
April 2019
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Factors influencing obesity among preschoolers: multilevel approach.

Int Nurs Rev 2019 Apr 23. Epub 2019 Apr 23.

College of Nursing, Florida State University, Tallahassee, FL, USA.

Background: Childhood obesity is a complex and multifaceted problem involving interactions among child, family and community environment.

Aim: The purpose of this study was to examine the contributing factors to early childhood obesity within a multilevel context, including child and family, childcare setting and community.

Methods: A cross-sectional, quantitative research design was employed. Read More

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http://dx.doi.org/10.1111/inr.12513DOI Listing

The neural development of empathy is sensitive to caregiving and early trauma.

Nat Commun 2019 Apr 23;10(1):1905. Epub 2019 Apr 23.

Interdisciplinary Center, Herzliya, 46150, Israel.

Empathy is a core human social ability shaped by biological dispositions and caregiving experiences; yet the mechanisms sustaining maturation of the neural basis of empathy are unknown. Here, we followed eighty-four children, including 42 exposed to chronic war-related adversity, across the first decade of life, and assessed parenting, child temperament, and anxiety disorders as contributors to the neural development of empathy. At preadolescence, participants underwent magenetoencephalography while observing others' distress. Read More

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http://www.nature.com/articles/s41467-019-09927-y
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http://dx.doi.org/10.1038/s41467-019-09927-yDOI Listing
April 2019
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Isolated myeloid sarcoma of the temporal bone: As the first clinical manifestation of acute myeloid leukemia in a patient of down's syndrome.

Int J Surg Case Rep 2019 Mar 28;58:77-80. Epub 2019 Mar 28.

Dept. of Pathology, PGIMS Rohtak, Haryana, India. Electronic address:

Introduction: Leukemia is the most common malignancy of childhood but myeloid sarcoma is a rare presentation of underlying leukemic disorder. Myeloid sarcoma (MS) is a rare tumor composed of proliferation of myeloid precursors at extramedullary sites.

Presentation Of Case: We report an unusual case of myeloid sarcoma involving the temporal bone in a young male child who presented with a large mass involving the left temporal region. Read More

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http://dx.doi.org/10.1016/j.ijscr.2019.03.027DOI Listing

[Clinical effect of vitamin D combined with the Early Start Denver Model in the treatment of autism spectrum disorder in toddlers].

Zhongguo Dang Dai Er Ke Za Zhi 2019 Apr;21(4):337-341

Department of Developmental-Behavioral Pediatrics, First Hospital of Jilin University, Changchun 130021, China.

Objective: To study the clinical effect of vitamin D (VitD) combined with the Early Start Denver Model (ESDM) in the treatment of autism spectrum disorder (ASD) in toddlers.

Methods: A total of 102 toddlers with ASD, aged 1 to 3 years, were enrolled. According to the wishes of their parents, they were divided into conventional rehabilitation, ESDM and ESDM+VitD groups. Read More

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Deprivation and threat, emotion dysregulation, and psychopathology: Concurrent and longitudinal associations.

Dev Psychopathol 2019 Apr 24:1-11. Epub 2019 Apr 24.

Department of Psychology and Neuroscience,University of North Carolina at Chapel Hill,Chapel Hill, NC,USA.

Maltreatment increases risk for psychopathology in childhood and adulthood, thus identifying mechanisms that influence these associations is necessary for future prevention and intervention. Emotion dysregulation resulting from maltreatment is one potentially powerful mechanism explaining risk for psychopathology. This study tests a conceptual model that distinguishes deprivation and threat as distinct forms of exposure with different pathways to psychopathology. Read More

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http://dx.doi.org/10.1017/S0954579419000294DOI Listing

Adult hypophosphatasia with compound heterozygous p.Phe327Leu missense and c.1559delT frameshift mutations in tissue-nonspecific alkaline phosphatase gene: a case report.

J Med Case Rep 2019 Apr 24;13(1):101. Epub 2019 Apr 24.

Department of General Medicine, Gunma University Graduate School of Medicine, 3-39-15 Showa-machi, Maebashi, Gunma, 371-8511, Japan.

Background: Hypophosphatasia is an inherited bone disease characterized by low alkaline phosphatase activity encoded by ALPL. Clinically, hypophosphatasia can be categorized as perinatal, infantile, childhood, and adult forms, as well as odonto-hypophosphatasia, according to the age at first sign or dental manifestations. Adult hypophosphatasia typically presents in middle-aged patients who appear to be in good health in early adulthood and manifests as painful feet caused by recurrent, slow-healing stress fractures of the lower limb. Read More

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https://jmedicalcasereports.biomedcentral.com/articles/10.11
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http://dx.doi.org/10.1186/s13256-019-2045-4DOI Listing
April 2019
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Time to diagnosis of retinoblastoma in Latin America: A systematic review.

Pediatr Hematol Oncol 2019 Apr 24:1-18. Epub 2019 Apr 24.

b Instituto Nacional de Câncer José Gomes de Alencar - Pediatric Oncology.

Retinoblastoma (RB) is the most common intraocular tumor of childhood. In low income countries, Time to diagnosis (TTD: interval between first symptom and diagnosis) has been associated with extraocular disease, metastasis and mortality. However, the relationship between TTD and prognosis is complex and not simply a linear correlation, particularly if TTD is <6 months. Read More

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https://www.tandfonline.com/doi/full/10.1080/08880018.2019.1
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http://dx.doi.org/10.1080/08880018.2019.1605432DOI Listing
April 2019
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Energy, Macronutrient Intake, and Anthropometrics of Vegetarian, Vegan, and Omnivorous Children (1⁻3 Years) in Germany (VeChi Diet Study).

Nutrients 2019 Apr 12;11(4). Epub 2019 Apr 12.

Fachhochschule des Mittelstands (FHM), University of Applied Sciences, 33602 Bielefeld, Germany.

Due to the lack of current, large-scale studies examining their dietary intake and health, there are concerns about vegetarian (VG) and vegan (VN) diets in childhood. Therefore, the Vegetarian and Vegan Children Study (VeChi Diet Study) examined the energy and macronutrient intake as well as the anthropometrics of 430 VG, VN, and omnivorous (OM) children (1⁻3 years) in Germany. A 3-day weighed dietary record assessed dietary intake, and an online questionnaire assessed lifestyle, body weight (BW), and height. Read More

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http://dx.doi.org/10.3390/nu11040832DOI Listing
April 2019
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Types of materials for frontalis sling surgery for congenital ptosis.

Cochrane Database Syst Rev 2019 Apr 23;4:CD012725. Epub 2019 Apr 23.

Department of Ophthalmology, Montefiore Medical Center, Albert Einstein College of Medicine, 3332 Rochambeau Avenue, 3rd Floor, Bronx, NY, USA, 10467.

Background: Congenital ptosis is a drooping of one or both eyelids at birth, often due to poor development of the levator palpebrae superioris muscle. This can result in amblyopia, astigmatism, and ocular torticollis and therefore may necessitate surgical intervention in early childhood if visual development is compromised. Patients may have varied levels of levator function. Read More

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http://dx.doi.org/10.1002/14651858.CD012725.pub2DOI Listing

Tactile sensitivity, tactile acuity, and affective touch: from childhood to early adolescence.

Somatosens Mot Res 2019 Apr 23:1-7. Epub 2019 Apr 23.

b Department of Psychology , Sapienza University of Rome , Rome , Italy.

The development of somatosensation and affective touch acquires a central role throughout our lives, for several reasons. In adults, these functions are driven by different, neuroanatomically and functionally segregated fibres. To date, very little is known about the basic features of these fibres in childhood and this lack of knowledge is mirrored in the affective touch domain, where there are no studies on the main physiological features of the tactile processes linked to the stimulation of the hairy skin, namely the preferential site of affective touch. Read More

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http://dx.doi.org/10.1080/08990220.2019.1604334DOI Listing

Genetic Analysis Reveals Complete Androgen Insensitivity Syndrome in Female Children Surgically Treated for Inguinal Hernia.

J Invest Surg 2019 Apr 23:1-7. Epub 2019 Apr 23.

e Division of Human Genetics , Centre for Biomedical Research Faculty of Medicine Diponegoro University (FMDU) , Semarang , Indonesia.

Background: Complete androgen insensitivity syndrome (CAIS) is a congenital condition caused by genetic defects in the androgen receptor (AR) gene located on the X chromosome, which lead to a phenotypical female individual with a 46, XY karyotype. Early diagnosis of CAIS is essential for proper clinical management, allows assessment of familial risk and contributes to healthcare decisions. However, diagnosis of CAIS can be overlooked in girls with inguinal hernia, resulting in inappropriate management. Read More

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http://dx.doi.org/10.1080/08941939.2019.1602690DOI Listing

Rapid early increase in BMI is associated with impaired longitudinal growth in children with cystic fibrosis.

Pediatr Pulmonol 2019 Apr 22. Epub 2019 Apr 22.

Department of Pediatric Endocrinology, University Medical Center Utrecht, Utrecht, The Netherlands.

Background: We aimed to assess whether final height in children with cystic fibrosis (CF) is affected by body mass index (BMI), BMI increase, pulmonary function, and cystic fibrosis-related diabetes (CFRD).

Study Design: A longitudinal, retrospective study was performed in a cohort of 57 patients with CF (30 boys, 27 girls) born between 1997 and 2001. Height and weight were recorded annually from ages 0. Read More

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http://dx.doi.org/10.1002/ppul.24343DOI Listing

A storytelling intervention reduces childhood caries risk behaviors among American Indian and Alaska Native mothers in Northern California.

J Public Health Dent 2019 Apr 23. Epub 2019 Apr 23.

Department of Health Policy and Health Services Research, Boston University Henry M. Goldman School of Dental Medicine, Boston, MA, USA.

Objectives: To evaluate a storytelling intervention targeting the oral health beliefs, knowledge, and behaviors of AIAN pregnant women and mothers.

Methods: Fifty-three adult AIAN women from three tribal communities in Northern California participated. The intervention story delivered oral health messaging using a traditional storytelling format. Read More

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https://onlinelibrary.wiley.com/doi/abs/10.1111/jphd.12318
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http://dx.doi.org/10.1111/jphd.12318DOI Listing
April 2019
1 Read

Treatment guidelines for persistent cloaca, cloacal exstrophy, and Mayer-Rokitansky-Küster-Häuser syndrome for the appropriate transitional care of patients.

Surg Today 2019 Apr 22. Epub 2019 Apr 22.

Research Team for the Establishment of Treatment Guidelines for Persistent Cloaca, Cloacal Exstrophy and Mayer-Rokitansky-Küster-Häuser Syndrome for the Proper Transitional Care of the Patients, The Research Project for Rare and Intractable Diseases of the Ministry of Health, Labour and Welfare (MHLW), Tokyo, Japan.

We developed treatment guidelines (TGs) for appropriate transitional care of the genitourinary system in patients with persistent cloaca (PC), cloacal exstrophy (CE), or Mayer-Rokitansky-Küster-Häuser syndrome (MRKH). These TGs are in accordance with the Medical Information Network Distribution Service (Minds), published in 2014 in Japan. Clinical questions (CQs) concerning treatment outcomes of the genitourinary system, pregnancy and delivery, and quality of life in adulthood were prepared as six themes for PC and CE and five themes for MRKH. Read More

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http://dx.doi.org/10.1007/s00595-019-01810-zDOI Listing

Case report: chronic inflammatory ulcer and osteoradionecrosis of the skull following radiotherapy in early childhood.

Oral Maxillofac Surg 2019 Apr 23. Epub 2019 Apr 23.

Department of Oral and Maxillofacial Surgery and Plastic Operations, Central Medical Centre Bremen, Bremen, Germany.

Introduction: Chronic inflammatory diseases of the skin are the most common differential diagnosis of tumorous lesions of the craniofacial region. Detailed information about a patient's medical history is important for the clinical diagnosis of such cases. Previous radiotherapy should be taken into account, especially in cases of chronic dermatitis, since complications include osteoradionecrois of the adjacent bone strucutres with surrounding inflammation. Read More

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http://dx.doi.org/10.1007/s10006-019-00752-7DOI Listing

Pallister-Hall Syndrome Presenting in Adolescence.

Case Rep Genet 2019 18;2019:6845836. Epub 2019 Mar 18.

Division of Pediatric Endocrinology, Rutgers-Robert Wood Johnson Medical School, 89 French Street 2nd Floor, New Brunswick, NJ 08901, USA.

Pallister-Hall syndrome (PHS) is an extremely rare syndrome of unknown prevalence with autosomal dominant inheritance due to gene mutations classically characterized by the presence of a hypothalamic hamartoma and polydactyly. Additional diagnostic criteria include bifid epiglottis, imperforate anus, small nails, hypopituitarism, growth hormone deficiency, and genital hypoplasia. It is typically diagnosed in infancy and early childhood, presenting with seizures and/or precocious puberty due to the hypothalamic hamartoma, and with limb anomalies due to central polydactyly. Read More

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https://www.hindawi.com/journals/crig/2019/6845836/
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http://dx.doi.org/10.1155/2019/6845836DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6442444PMC
March 2019
1 Read

Multiple subacute bilateral cerebral infarcts in a 9-year-old Nigerian male: a case of childhood primary angiitis of the central nervous system.

Pan Afr Med J 2018 10;31:99. Epub 2018 Oct 10.

Children's Emergency Room (CHER), Ward 12 (children's in-patient ward) and the Paediatric Neurology Clinic, Federal Medical Centre, Owerri, Nigeria.

A Primary Angiitis of the Central Nervous System (PACNS) is ill-defined, complex and rare in children. Clinical presentation is variable, diagnosis is challenging and it is life-threatening but treatable. The index case is a 9-year old male who presented with progressively slurred speech, progressive weakness of the limbs, hemifacial weakness and vomiting. Read More

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http://dx.doi.org/10.11604/pamj.2018.31.99.13898DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6462305PMC
October 2018

Health Supervision for Children With Neurofibromatosis Type 1.

Pediatrics 2019 Apr 22. Epub 2019 Apr 22.

Neurofibromatosis type 1 (NF1) is a multisystem disorder that primarily involves the skin and peripheral nervous system. Its population prevalence is approximately 1 in 3000. The condition is usually recognized in early childhood, when pigmentary manifestations emerge. Read More

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http://dx.doi.org/10.1542/peds.2019-0660DOI Listing

Early-life Chronic Stressors, Rumination, and the Onset of Vulvodynia.

J Sex Med 2019 Apr 19. Epub 2019 Apr 19.

Department of Epidemiology and Community Health, University of Minnesota, Minneapolis, MN, USA; Department of Epidemiology, Boston University School of Public Health, Boston, MA, USA.

Introduction: Vulvodynia is a debilitating, chronic vulvar pain condition. Community-based case-control studies have consistently shown associations between early-life chronic stressors and vulvodynia onset.

Aim: We examined rumination as a specific stress response involved in the psychobiological mechanism of vulvodynia. Read More

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http://dx.doi.org/10.1016/j.jsxm.2019.03.010DOI Listing

Uncontrolled Eating during Pregnancy Predicts Fetal Growth: The Healthy Mom Zone Trial.

Nutrients 2019 Apr 21;11(4). Epub 2019 Apr 21.

Exercise Psychology Laboratory, Department of Kinesiology, The Pennsylvania State University, University Park, State College, PA 16802, USA.

Excess maternal weight gain during pregnancy elevates infants' risk for macrosomia and early-onset obesity. Eating behavior is also related to weight gain, but the relationship to fetal growth is unclear. We examined whether Healthy Mom Zone, an individually tailored, adaptive gestational weight gain intervention, and maternal eating behaviors affected fetal growth in pregnant women ( = 27) with a BMI > 24. Read More

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https://www.mdpi.com/2072-6643/11/4/899
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http://dx.doi.org/10.3390/nu11040899DOI Listing
April 2019
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Abdominal Pain in Children Develops With Age and Increases With Psychosocial Factors.

Clin Gastroenterol Hepatol 2019 Apr 19. Epub 2019 Apr 19.

Div of Pediatrics, Dept of Clinical and Experimental Medicine, Linköping university SE 58185 Linköping, Sweden; Crown Princess Victoria Children´s Hospital, Region Östergötland, Linköping, Sweden.

Background & Aims: Functional gastrointestinal disorders are highly prevalent, cause significant suffering, and are costly to society. Pain is a central feature of 2 of the most common functional gastrointestinal disorders-irritable bowel syndrome and functional dyspepsia. Although these disorders have been well studied in adults, their etiology is poorly understood. Read More

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https://linkinghub.elsevier.com/retrieve/pii/S15423565193042
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http://dx.doi.org/10.1016/j.cgh.2019.04.036DOI Listing
April 2019
1 Read

The development of a theory-based eHealth app prototype to promote oral health during prenatal care visits.

Transl Behav Med 2019 Apr 22. Epub 2019 Apr 22.

Nudgently, LLC, Eugene, OR, USA.

Poor maternal oral health during pregnancy is associated with adverse maternal and child outcomes, including preterm birth and early childhood caries. Subsequently, professional associations have developed prenatal oral health guidelines, but significant gaps exist in implementing guidelines into clinical practice. The purpose of this study was to develop and test the usability of an innovative, theory-driven, eHealth application ("app") to facilitate prenatal providers' (nurse practitioners and midwives) implementation of oral health promotion during prenatal care visits. Read More

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http://dx.doi.org/10.1093/tbm/ibz047DOI Listing

Predicting childhood obesity using electronic health records and publicly available data.

PLoS One 2019 22;14(4):e0215571. Epub 2019 Apr 22.

NYU Langone Comprehensive Program on Obesity, NYU School of Medicine, New York, New York, United States of America.

Background: Because of the strong link between childhood obesity and adulthood obesity comorbidities, and the difficulty in decreasing body mass index (BMI) later in life, effective strategies are needed to address this condition in early childhood. The ability to predict obesity before age five could be a useful tool, allowing prevention strategies to focus on high risk children. The few existing prediction models for obesity in childhood have primarily employed data from longitudinal cohort studies, relying on difficult to collect data that are not readily available to all practitioners. Read More

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http://journals.plos.org/plosone/article?id=10.1371/journal.pone.0215571PLOS

The consequences of foster care versus institutional care in early childhood on adolescent cardiometabolic and immune markers: Results from a randomized controlled trial.

Psychosom Med 2019 Apr 18. Epub 2019 Apr 18.

Department of Human Development and Quantitative Methodology, University of Maryland, College Park, MD, USA.

Objective: Children exposed to institutional rearing often exhibit problems across a broad array of developmental domains. We compared the consequences of long-term high-quality foster care versus standard institution-based care which began in early childhood on cardiometabolic and immune markers assessed at the time of adolescence.

Methods: The Bucharest Early Intervention Project is a longitudinal investigation of children institutionalized during early childhood (ages 6 to 30 months at baseline) who were subsequently randomized to either high-quality foster care or continued institutional care. Read More

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http://dx.doi.org/10.1097/PSY.0000000000000696DOI Listing
April 2019
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Identification of novel Adenosine Deaminase 2 gene variants and varied clinical phenotype in pediatric vasculitis.

Arthritis Rheumatol 2019 Apr 22. Epub 2019 Apr 22.

BC Children's Hospital Research Institute, BC Children's Hospital, Vancouver, BC, Canada.

Objectives: Individuals with deficiency of adenosine deaminase 2 (DADA2), a recently recognized autosomal recessive disease, present with various systemic vascular and inflammatory manifestations, often with early-onset age, or recurrent strokes. Their clinical features and histological findings overlap with those of childhood onset polyarteritis nodosa (PAN), a primary "idiopathic" systemic vasculitis. Despite similar clinical presentation, individuals with DADA2 may respond better to biologic therapy than traditional immunosuppression. Read More

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http://dx.doi.org/10.1002/art.40913DOI Listing

Aortic pulse wave velocity in children with Cushing syndrome: A window into a marker of early cardiovascular disease.

Endocrinol Diabetes Metab 2019 Apr 15;2(2):e00054. Epub 2019 Jan 15.

Section on Endocrinology and Genetics Eunice Kennedy Shriver National Institute of Child Health Bethesda Maryland.

Objective: To investigate early signs of cardiovascular arterial remodelling in paediatric patients with Cushing syndrome (CS) in comparison with normative values from healthy children.

Study Design: The metrics used to assess cardiac health were from thoracic aorta and carotid MRI. Scans were performed on 18 children with CS (mean: 12. Read More

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http://dx.doi.org/10.1002/edm2.54DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6458483PMC

Association of nuts and unhealthy snacks with subclinical atherosclerosis among children and adolescents with overweight and obesity.

Nutr Metab (Lond) 2019 8;16:23. Epub 2019 Apr 8.

1Department of Nutrition, School of Health, Qazvin University of Medical Sciences, Qazvin, Iran.

Background: The process of atherosclerosis begins early in childhood and usually remains asymptomatic until later in life. Carotid intima-media thickness (cIMT) as a marker of subclinical atherosclerosis could identify early vascular alterations. Unhealthy snacks consumption is associated with obesity and other CVD risk factors in children and adolescents. Read More

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http://dx.doi.org/10.1186/s12986-019-0350-yDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6454780PMC

The effects of the transition from home-based childcare to childcare centers on children's health and development in Colombia.

Early Child Res Q 2019 Apr-Jun;47:418-431

University College London, Department of Economics, Gower Street, London WC1E6BT, UK.

Colombia's national early childhood strategy launched in 2011 aimed at improving the quality of childcare services offered to socio-economically vulnerable children, and included the possibility that children and their childcare providers could transfer from non-parental family daycare units to large childcare centers in urban areas. This study seeks to understand whether the offer to transfer and the actual transfer from one program to the other had an impact on child cognitive and socioemotional development, and nutrition, using a cluster-randomized control trial with a sample of 2767 children between the ages of 6 and 60 months located in 14 cities in Colombia. The results indicate a negative effect of this initiative on cognitive development, a positive effect on nutrition, and no statistically significant effect of the intervention on socioemotional development. Read More

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http://dx.doi.org/10.1016/j.ecresq.2018.08.005DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6472518PMC

Tablet Use in Young Children is Associated with Advanced Fine Motor Skills.

J Mot Behav 2019 Apr 22:1-8. Epub 2019 Apr 22.

a Department of Physical Therapy , Federal University of Jequitinhonha and Mucuri Valleys (UFVJM) , Diamantina , Brazil .

To evaluate whether frequent interactive tablet-use at preschool age is associated with improved fine motor skills and to describe tablet-use in young children. Cross-sectional study with 78 children, aged 24-42 months: group 1 with previous frequent tablet-use exposure (n = 26), group 2 without previous tablet-use exposure (n = 52). Fine motor skills were evaluated with the Bayley-III. Read More

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http://dx.doi.org/10.1080/00222895.2019.1602505DOI Listing

Early life stress by repeated maternal separation induces long-term neuroinflammatory response in glial cells of male rats.

Stress 2019 Apr 22:1-8. Epub 2019 Apr 22.

a Laboratory of Neuroscience, Department of Psychology , University of Oviedo , Oviedo , Spain.

Childhood maltreatment and neglect lead to a wide range of mental disorders highlighted by hormone and immune alterations in neglected children. This social-health challenge has led to the creation of early stress models such as maternal separation (MS) in rodents. We performed a MS model (4 h per day, 21 days; n = 16 MS and n = 16 control), and then measured three parameters in adult male rat brains, in order to look for long-term effects of early life stress. Read More

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http://dx.doi.org/10.1080/10253890.2019.1604666DOI Listing

Fluctuating body asymmetry in young Polish women in relation to childhood socioeconomic status.

J Biosoc Sci 2019 Apr 22:1-9. Epub 2019 Apr 22.

1Department of Anthropology,Institute of Zoology and Biomedical Research,Jagiellonian University,Cracow,Poland.

The aim of this study was to analyse the relationship between childhood socioeconomic conditions and body asymmetry in young Polish women. The study measured fluctuating asymmetry (FA), which refers to small random deviations from perfect symmetry in bilaterally paired body structures. Data were obtained from 620 female students aged from 19 to 25 years recruited from Jagiellonian University in Cracow, Poland. Read More

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https://www.cambridge.org/core/product/identifier/S002193201
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http://dx.doi.org/10.1017/S0021932019000099DOI Listing
April 2019
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Parenting styles as a predictor of long-term psychosocial outcomes after traumatic brain injury (TBI) in early childhood.

Disabil Rehabil 2019 Apr 21:1-7. Epub 2019 Apr 21.

e Department of Psychology, Hotchkiss Brain Institute & Alberta Children's Hospital Research Institute , University of Calgary , Calgary , Canada.

Objective: This study sought to determine whether parenting styles predict long-term psychosocial outcomes after traumatic brain injury in young children.

Methods: The study involved a concurrent cohort, prospective design, with longitudinal assessments up to early adolescence. Participants included 126 children with moderate to severe traumatic brain injury or orthopedic injury, ages 3 to 6 years 11 months, recruited between 2003 and 2006. Read More

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https://www.tandfonline.com/doi/full/10.1080/09638288.2019.1
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http://dx.doi.org/10.1080/09638288.2019.1602676DOI Listing
April 2019
1 Read

Family-centred oral health promotion through Victorian child-health services: a pilot.

Health Promot Int 2019 Apr 21. Epub 2019 Apr 21.

Dental Health Services Victoria, 720 Swanston Street, Carlton, Victoria 3053, Australia.

Maternal and Child Health Services (MCHS) provide ideal settings for oral disease prevention. In Victoria (Australia), child mouth-checks (Lift-the-Lip) and oral health promotion (OHP) occur during MCHS child visits. This study trialled Tooth-Packs (OHP resources, toothbrushes, toothpastes) distribution within MCHS to (i) assess the impacts of Tooth-Packs distribution on child and family oral health (OH) behaviours and knowledge, including Maternal and Child Health Nurses (MCHN) child referral practices to dental services, and (ii) determine the feasibility and acceptability of incorporating Tooth-Packs distribution into MCHN OHP practices. Read More

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http://dx.doi.org/10.1093/heapro/daz025DOI Listing

Cardiovascular manifestations of sickle cell disease.

Eur Heart J 2019 Apr 21. Epub 2019 Apr 21.

Sorbonne Université, Inserm, Institute of Cardiometabolism and Nutrition (ICAN), ACTION Study Group and Department of Cardiology, Institute of Cardiology (AP-HP), Hôpital Pitié- Salpêtrière, Boulevard de l'hôpital, Paris F-75013, France.

Sickle cell disease (SCD) is the most frequent genetic haemoglobinopathy worldwide. Early childhood mortality has dramatically decreased in high-income countries, and most patients now survive beyond the 5th decade. However, in the aging SCD population, the morbidity related to chronic organ damage, especially kidney and heart, has become a major concern. Read More

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http://dx.doi.org/10.1093/eurheartj/ehz217DOI Listing

Stress, Epigenetics and Depression: A Systematic Review.

Neurosci Biobehav Rev 2019 Apr 18. Epub 2019 Apr 18.

Mood Disorders Psychopharmacology Unit, University Health Network, Toronto, ON, Canada; Institute of Medical Science, University of Toronto, Toronto, ON, Canada; Department of Pharmacology, University of Toronto, Toronto, ON, Canada; Department of Psychiatry, University of Toronto, Toronto, ON, Canada; Brain and Cognition Discovery Foundation, Toronto, ON, Canada.

Environmental stressors, such as childhood maltreatment, have been recognized to contribute to the development of depression. Growing evidence suggests that epigenetic changes are a key mechanism by which stressors interact with the genome leading to stable changes in DNA structure, gene expression, and behaviour. The current review aimed to evaluate the relationship between stress-associated epigenetic changes and depression. Read More

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https://linkinghub.elsevier.com/retrieve/pii/S01497634183095
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http://dx.doi.org/10.1016/j.neubiorev.2019.04.010DOI Listing
April 2019
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Early parental positive personality and stress: Longitudinal associations with children's sleep.

Br J Health Psychol 2019 Apr 19. Epub 2019 Apr 19.

Department of Psychology, Arizona State University, Tempe, AZ, USA.

Objectives: The current study examined the influence of early parental stress and positive parent personality during infancy on sleep in middle childhood. Further, the role of positive parent personality as a buffer of the association between parental stress and sleep was considered.

Methods: Participants included 381 twins and their primary caregivers who were recruited from birth records in the United States. Read More

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http://dx.doi.org/10.1111/bjhp.12372DOI Listing

Do expectant mothers know how early childhood caries can be prevented? A cross-sectional study.

Eur Arch Paediatr Dent 2019 Apr 19. Epub 2019 Apr 19.

Division of Population and Patient Health, King's College London Dental Institute, Denmark Hill, London, SE5 9RS, UK.

Aim: To evaluate the awareness, knowledge, and beliefs about early childhood caries (ECC) among a sample of expectant mothers and to determine their preferences to help design appropriate interventions.

Methods: Expectant mothers attending for antenatal care at a large public hospital were interviewed and asked to complete a questionnaire about ECC. The questionnaire was pre-tested and validated and contained questions about risk factors, presentations, management, and complications of ECC. Read More

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http://link.springer.com/10.1007/s40368-019-00442-8
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http://dx.doi.org/10.1007/s40368-019-00442-8DOI Listing
April 2019
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The Kansas University DHA Outcomes Study (KUDOS) clinical trial: long-term behavioral follow-up of the effects of prenatal DHA supplementation.

Am J Clin Nutr 2019 Apr 20. Epub 2019 Apr 20.

Department of Dietetics and Nutrition, University of Kansas Medical Center, Kansas City, KS.

Background: Docosahexaenoic acid (DHA) is a long-chain polyunsaturated fatty acid that has been linked to improved vision and cognition in postnatal feeding studies and has been consistently associated with reduction of early preterm birth in prenatal supplementation trials. This is a report of the first long-term follow-up of infants from mothers receiving prenatal DHA supplementation in a US cohort.

Objective: Our objective was to evaluate the efficacy of the prenatal supplementation on both global and granular longitudinal assessments of cognitive and behavioral development. Read More

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https://academic.oup.com/ajcn/advance-article/doi/10.1093/aj
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http://dx.doi.org/10.1093/ajcn/nqz018DOI Listing
April 2019
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Lifestyle Behavior and Mental Health in Early Adolescence.

Pediatrics 2019 Apr 19. Epub 2019 Apr 19.

Population Health Intervention Research Unit, School of Public Health, Edmonton, University of Alberta, Edmonton, Canada;

Background And Objectives: Mental illnesses affect >15% of Canadian adolescents. New preventive strategies are critically needed. We examined the associations of meeting established recommendations for diet, physical activity, sleep, and sedentary behavior in childhood with mental illness in adolescence. Read More

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http://pediatrics.aappublications.org/lookup/doi/10.1542/ped
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http://dx.doi.org/10.1542/peds.2018-3307DOI Listing
April 2019
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Dietary calories and lipids synergistically shape adipose tissue cellularity during postnatal growth.

Mol Metab 2019 Apr 5. Epub 2019 Apr 5.

DKFZ Junior Group Metabolism and Stem Cell Plasticity, German Cancer Research Center, Im Neuenheimer Feld 280, Heidelberg 69120, Germany. Electronic address:

Objective: The susceptibility to abdominal obesity and the metabolic syndrome is determined to a substantial extent during childhood and adolescence, when key adipose tissue characteristics are established. Although the general impact of postnatal nutrition is well known, it is not clear how specific dietary components drive adipose tissue growth and how this relates to the risk of metabolic dysfunction in adulthood.

Methods: Adipose tissue growth including cell proliferation was analyzed in juvenile mice upon dietary manipulation with in vivo nucleotide labeling. Read More

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http://dx.doi.org/10.1016/j.molmet.2019.03.012DOI Listing

Epileptic spasm and other forms of epilepsy in presumed perinatal arterial ischemic stroke in Turkey after more than 10 years follow-up: A single centre study.

Brain Dev 2019 Apr 16. Epub 2019 Apr 16.

Department of Neuroradiology, Istanbul Faculty of Medicine, Istanbul, Turkey.

Purpose: To identify the frequency of epilepsy and whether the association of epilepsy with clinical and neuroimaging findings in children with presumed perinatal arterial ischemic stroke (PPAIS).

Methods: We performed a retrospective analysis of 37 children with PPAIS followed-up at a tertiary referral center between January 1, 2000, and October 31, 2016. Clinical data including demographic features, age at onset of symptoms and seizures, initial clinical presentation, epilepsy features, used antiepileptic drugs, and thrombophilia screening results were abstracted from medical records. Read More

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https://linkinghub.elsevier.com/retrieve/pii/S03877604193009
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http://dx.doi.org/10.1016/j.braindev.2019.04.004DOI Listing
April 2019
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Food Marketing Influences Children's Attitudes, Preferences and Consumption: A Systematic Critical Review.

Nutrients 2019 Apr 18;11(4). Epub 2019 Apr 18.

Psychological Sciences, Institute of Psychology, Health and Society, University of Liverpool, Bedford Street South, Liverpool L69 7ZA, UK.

Exposure to the marketing of unhealthy foods and beverages is a widely acknowledged risk factor for the development of childhood obesity and noncommunicable diseases. Food marketing involves the use of numerous persuasive techniques to influence children's food attitudes, preferences and consumption. This systematic review provides a comprehensive contemporary account of the impact of these marketing techniques on children aged 0-18 years and critically evaluates the methodologies used. Read More

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http://dx.doi.org/10.3390/nu11040875DOI Listing

Prevalence of adverse childhood experiences (ACEs) among US children.

Child Abuse Negl 2019 Apr 16;92:209-218. Epub 2019 Apr 16.

University of South Carolina College of Nursing, Columbia, South Carolina, United States.

Objective: The purpose of this study was to estimate the prevalence of adverse childhood experiences (ACEs) among children in the United States and to examine the relationship between child and family characteristics and the likelihood of reported exposure to ACEs.

Methods: Data were drawn from the nationally representative 2016 National Survey of Children's Health (NSCH). Parent-reported child ACE exposure was measured using counts of those reporting zero ACEs, one to three ACEs, and four or more ACEs. Read More

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https://linkinghub.elsevier.com/retrieve/pii/S01452134193013
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http://dx.doi.org/10.1016/j.chiabu.2019.04.010DOI Listing
April 2019
3 Reads

Polygenic Prediction of Weight and Obesity Trajectories from Birth to Adulthood.

Cell 2019 Apr;177(3):587-596.e9

Center for Genomic Medicine, Massachusetts General Hospital, Boston, MA 02114, USA; Division of Cardiology, Massachusetts General Hospital, Boston, MA 02114, USA; Cardiovascular Disease Initiative, Broad Institute of MIT and Harvard, Cambridge, MA 02142, USA; Department of Medicine, Harvard Medical School, Boston, MA 02115, USA. Electronic address:

Severe obesity is a rapidly growing global health threat. Although often attributed to unhealthy lifestyle choices or environmental factors, obesity is known to be heritable and highly polygenic; the majority of inherited susceptibility is related to the cumulative effect of many common DNA variants. Here we derive and validate a new polygenic predictor comprised of 2. Read More

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https://linkinghub.elsevier.com/retrieve/pii/S00928674193029
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http://dx.doi.org/10.1016/j.cell.2019.03.028DOI Listing
April 2019
3 Reads

Polygenic Risk Scores Expand to Obesity.

Cell 2019 Apr;177(3):518-520

Scripps Research Translational Institute, La Jolla, CA 92037, USA; Department of Molecular Medicine, Scripps Research, La Jolla, CA 92037, USA. Electronic address:

Obesity is one of the most serious health challenges of our time. In this issue of Cell, Khera and co-authors demonstrate the striking ability of genetics, in the form of a polygenic risk score, to identify those individuals at high risk for obesity. This genetic risk expresses itself early as childhood obesity, reinforcing the notion that early prevention is essential to combatting the obesity epidemic. Read More

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https://linkinghub.elsevier.com/retrieve/pii/S00928674193038
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http://dx.doi.org/10.1016/j.cell.2019.03.051DOI Listing
April 2019
1 Read