54,154 results match your criteria Myoclonic Epilepsy Beginning in Infancy or Early Childhood


Diurnal Patterns of Energy Intake Derived via Principal Component Analysis and Their Relationship with Adiposity Measures in Adolescents: Results from the National Diet and Nutrition Survey RP (2008⁻2012).

Nutrients 2019 Feb 17;11(2). Epub 2019 Feb 17.

Brain, Performance and Nutrition Research Centre, Northumbria University, Newcastle NE1 8ST, UK.

Mounting evidence points towards the existence of an association between energy intake in the evening and an increased prevalence and risk of being overweight and of obesity. The present study aimed to describe diurnal eating patterns (DEP) in a nationally representative sample of UK adolescents and to relate the derived DEP to anthropometrical measures. Data from four-day food records of adolescents aged 11⁻18 years participating in the 2008⁻2012 UK National Diet and Nutrition Survey Rolling Programme (NDNS RP) was utilised. Read More

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http://dx.doi.org/10.3390/nu11020422DOI Listing
February 2019

[Hygienic safety of infant milk powder formulas in hospital setting].

Ig Sanita Pubbl 2018 Sep-Oct;74(5):433-442

Sezione di Igiene - Istituto di Sanità Pubblica, Università Cattolica del Sacro Cuore, IRCCS Fondazione Policlinico "Agostino Gemelli", Roma, Italia.

The authors present the results of a study whose aim was to assess the hygienic quality of powder and reconstituted milk for early childhood, in a University General Hospital in Rome, Italy. This procedure is an integral part of the systematic verification activities that the hospital Health Management department considers as a priority for patient safety. The absence of contamination in all tested samples confirms the suitability of adopted procedures to ensure a safe product, considering the increased vulnerability of newborns, especially if preterm. Read More

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February 2019

Effects of delayed cord clamping on infants after neonatal period: A systematic review and meta-analysis.

Int J Nurs Stud 2019 Feb 8;92:97-108. Epub 2019 Feb 8.

Peking University School of Nursing, #38 Xueyuan Road, Hai Dian District, Beijing, 100191, PR China. Electronic address:

Background: The majority of current evidences simply showed the short-term benefits of delayed cord clamping, mainly focusing on the first week after birth. Without follow-up data, we can hardly come to the conclusion that delayed cord clamping may do more harm than good.

Objective: To evaluate the long-term effects of delayed cord clamping compared with early cord clamping on infants after neonatal period. Read More

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http://dx.doi.org/10.1016/j.ijnurstu.2019.01.012DOI Listing
February 2019

Factors contributing to parent-child interaction quality following mild traumatic brain injury in early childhood.

J Neuropsychol 2019 Feb 19. Epub 2019 Feb 19.

Ste-Justine Research Center, Montreal, Quebec, Canada.

There is emerging evidence that parent-child interactions are affected by early childhood traumatic brain injury (TBI). These findings are of functional importance when considering the high prevalence of TBI in early childhood alongside evidence that young children exposed to positive relationships with their parents early in life exhibit better social functioning concurrently and longitudinally. Given that the overall quality of parent-child interactions is the result of both parent and child emotional and behavioural dispositions, it remains unclear which parental or child-related factors contribute to the quality of interactions post-TBI. Read More

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http://dx.doi.org/10.1111/jnp.12179DOI Listing
February 2019

Measuring Executive Function Skills in Young Children in Kenya: Associations with School Readiness.

Dev Sci 2019 Feb 18:e12818. Epub 2019 Feb 18.

International Education, RTI International, Washington, DC, USA.

Most of what is known about the association between children's executive function (EF) and school readiness skills is derived from research conducted in Western countries. We tested whether these associations were evident in a middle-income country context. Participants were 1,480 children, aged 4 to 7 years old, who participated in an endline assessment of the Tayari program, an early childhood education model that is being delivered by the Kenyan education system. Read More

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http://dx.doi.org/10.1111/desc.12818DOI Listing
February 2019

Measuring Young Children's Executive Function and Self-Regulation in Classrooms and Other Real-World Settings.

Clin Child Fam Psychol Rev 2019 Feb 18. Epub 2019 Feb 18.

Harvard Graduate School of Education, 704 Larsen Hall 14, Appian Way, Cambridge, MA, 02138, USA.

A number of different approaches are currently used for assessing young children's executive function (EF) and self-regulation (SR) skills. Nevertheless, guidance for stakeholders aiming to assess EF and SR in real-world settings (e.g. Read More

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http://dx.doi.org/10.1007/s10567-019-00285-1DOI Listing
February 2019

Associations of prenatal exposure to polybrominated diphenyl ethers and polychlorinated biphenyls with long-term gut microbiome structure: a pilot study.

Environ Epidemiol 2019 Feb;3(1)

Department of Environmental Health Sciences, Columbia Mailman School of Public Health, New York, NY, USA.

Background: The gut microbiome is influenced by early-life exposures, but-despite potentially enormous implications for child health-is understudied in environmental epidemiology. This pilot study is one of the first to explore exposures and long-term gut microbiome profiles. We examined the association between exposure to polybrominated diphenyl ethers (PBDEs) and polychlorinated biphenyls (PCBs) during pregnancy and the mid-childhood gut microbiome. Read More

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http://dx.doi.org/10.1097/EE9.0000000000000039DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6376400PMC
February 2019

Split-Brain Babies? Differences in Representation of Bilaterally and Unilaterally Presented Visual Stimuli in Infancy.

Authors:
Kimberly M Scott

Front Psychol 2018 4;9:2758. Epub 2019 Feb 4.

Early Childhood Cognition Lab, Department of Brain and Cognitive Sciences, Massachusetts Institute of Technology, Cambridge, MA, United States.

Information needed for perception and action is often distributed across the two hemispheres of the human brain. During development, representations lateralized due to topographic sensory maps may be available independently before they can be integrated across hemispheres. These studies (total = 211) investigate visual interhemispheric integration in two domains in infancy. Read More

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http://dx.doi.org/10.3389/fpsyg.2018.02758DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6369161PMC
February 2019

[Thrombodynamic parameters of hypercoagulation of blood in children with childhood autism and schizophrenia].

Zh Nevrol Psikhiatr Im S S Korsakova 2019 ;119(1):59-63

Mental Health Research Center of Russian Academy of Sciences, Moscow, Russia.

Aim: To detect blood plasma coagulability in children with mental diseases using a thrombodynamics test.

Material And Methods: The study included two groups of children. Group 1 included 11 patients with infantile psychosis in autism (F84. Read More

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http://dx.doi.org/10.17116/jnevro201911901159DOI Listing
January 2019

Population receptive field tuning properties of visual cortex during childhood.

Dev Cogn Neurosci 2019 Jan 8:100614. Epub 2019 Jan 8.

Dept. of Psychology, San Diego State University, USA.

Visuospatial abilities such as contrast sensitivity and Vernier acuity improve until late in childhood, but the neural mechanisms supporting these changes are poorly understood. We tested to which extent this development might reflect improved spatial sensitivity of neuronal populations in visual cortex. To do this, we measured BOLD-responses in areas V1-V4 and V3a, whilst 6- to 12-year-old children and adults watched large-field wedge and ring stimuli in the MRI scanner, and then fitted population receptive field (pRF) tuning functions to these data (Dumoulin and Wandell, 2008). Read More

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http://dx.doi.org/10.1016/j.dcn.2019.01.001DOI Listing
January 2019

Risk factors of early childhood caries (ECC) among children in Beijing - a prospective cohort study.

BMC Oral Health 2019 Feb 18;19(1):34. Epub 2019 Feb 18.

Department of Preventive Dentistry, Peking University School and Hospital of Stomatology, National Engineering Laboratory for Digital and Material Technology of Stomatology, Beijing Key Laboratory of Digital Stomatology, 22 Zhongguancun Avenue South, Haidian District, Beijing, 100081, People's Republic of China.

Background: Early childhood caries (ECC) was a serious oral health concern with high prevalence and a low treatment rate in China, and few researches have focused on preschool children. This study aimed to explore the risk factors of ECC in Beijing, China.

Methods: Totle of 712 children (mean age: 46. Read More

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http://dx.doi.org/10.1186/s12903-019-0721-9DOI Listing
February 2019

Emotional stimuli candidates for behavioural intervention in the prevention of early childhood caries: a pilot study.

BMC Oral Health 2019 Feb 18;19(1):33. Epub 2019 Feb 18.

Clinic of Stomatology, Institution Shared with St. Anne's Faculty Hospital, Faculty of Medicine, Masaryk University, Brno, Czech Republic.

Background: Oral diseases, such as early childhood caries (ECC), have a complex etiology with common, behaviour-related risk factors. Appropriately targeted behavioural intervention using effective tools can help to eliminate risk behaviour leading to ECC. The aim of this study was to ascertain which visual stimuli with a supporting text evoke the strongest emotional response in infants' mothers and, therefore, are suitable candidates for inclusion in behavioural interventions within the prevention of ECC. Read More

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http://dx.doi.org/10.1186/s12903-019-0718-4DOI Listing
February 2019

Prevalence of severe/morbid obesity and other weight status and anthropometric reference standards in Spanish preschool children: The PREFIT project.

Pediatr Res 2019 Feb 18. Epub 2019 Feb 18.

PROFITH "PROmoting FITness and Health through physical activity" research group, Department of Physical Education and Sports, Faculty of Sport Sciences, University of Granada, Granada, Spain.

Background: Childhood obesity has become a major health problem in children under the age of 5 years. Providing reference standards would help paediatricians to detect and/or prevent health problems related to both low and high levels of body mass and to central adiposity later in life. Therefore, the aim of this study was to examine the prevalence of different weight status categories and to provide sex- and age-specific anthropometry reference standards for Spanish preschool children. Read More

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http://dx.doi.org/10.1038/s41390-019-0325-8DOI Listing
February 2019

Relation of prenatal low-level mercury exposure with early child neurobehavioral development and exploration of the effects of sex and DHA on it.

Environ Int 2019 Feb 15;126:14-23. Epub 2019 Feb 15.

Ministry of Education-Shanghai Key Laboratory of Children's Environmental Health, Xinhua Hospital Affiliated to Shanghai Jiao Tong University School of Medicine, Shanghai, China. Electronic address:

Background: The extent to which low-level, in utero mercury exposure affects child neurobehavioral development during early childhood has been inconclusive. In addition, the effects of sex and docosahexaenoic acid (DHA) on these relationships remain unclear and controversial.

Objectives: This study aimed to explore the associations between prenatal low-level mercury exposure and child neurobehavioral development during the neonatal and toddler periods and to examine the potential confounding or interactive effects of sex and DHA status on these relationships. Read More

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http://dx.doi.org/10.1016/j.envint.2019.02.012DOI Listing
February 2019

Gene mutational analysis in a cohort of Chinese children with unexplained epilepsy: Identification of a new KCND3 phenotype and novel genes causing Dravet syndrome.

Seizure 2019 Jan 28;66:26-30. Epub 2019 Jan 28.

Department of Pediatrics, Peking University First Hospital, Beijing 100034, China. Electronic address:

Purpose: This study aimed to investigate the genetic etiology of epilepsy in a cohort of Chinese children.

Methods: Targeted next-generation sequencing (NGS) was performed for 120 patients with unexplained epilepsy, including 71 patients with early-onset epileptic encephalopathies, and 16 patients with Dravet syndrome (including three patients with a Dravet-like phenotype) but without SCN1A pathogenic variants.

Results: Pathogenic variants of 14 genes were discovered in 22 patients (18%). Read More

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http://dx.doi.org/10.1016/j.seizure.2019.01.025DOI Listing
January 2019

Comorbidities in primary versus secondary school children with obesity and responsiveness to lifestyle intervention.

J Clin Endocrinol Metab 2019 Feb 18. Epub 2019 Feb 18.

Centre for Overweight Adolescent and Children's Healthcare (COACH), Department of Paediatrics, Maastricht University Medical Centre, Maastricht, The Netherlands.

Context: Childhood obesity increases the risk of diseases as diabetes, cardiovascular disease and non-alcoholic fatty liver disease.

Objective: To evaluate the prevalence of comorbidities in school-age children with obesity and to compare its prevalence and the effect of a lifestyle intervention between children in primary and secondary school and between boys and girls.

Design: Cross-sectional analysis and lifestyle intervention. Read More

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http://dx.doi.org/10.1210/jc.2018-02318DOI Listing
February 2019

Age-specific Associations between Estradiol, Cortico-Amygdalar Structural Covariance, Verbal and Spatial Skills.

J Neuroendocrinol 2019 Feb 18:e12698. Epub 2019 Feb 18.

Brain Development Cooperative Group.

Estradiol is known to play an important role in the developing human brain, but little is known on the entire network of potential regions which might be affected and on how these effects may vary from childhood to early adulthood, which in turn can explain sexually differentiated behaviors. Here we examined the relationship between estradiol, cortico-amygdalar structural covariance, and cognitive or behavioral measures typically showing sex differences (verbal/spatial skills, anxious-depressed symptomatology) in 152 children and adolescents (6-22 years old). Cortico-amygdalar structural covariance shifted from positive to negative across the age range. Read More

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http://dx.doi.org/10.1111/jne.12698DOI Listing
February 2019

Development of inhibitory control during childhood and its relations to early temperament and later social anxiety: unique insights provided by latent growth modeling and signal detection theory.

J Child Psychol Psychiatry 2019 Feb 18. Epub 2019 Feb 18.

Department of Human Development and Quantitative Methodology, University of Maryland, College Park, MD, USA.

Background: Children with the temperament of behavioral inhibition (BI) face increased risk for social anxiety. However, not all children with BI develop anxiety symptoms. Inhibitory control (IC) has been suggested as a moderator of the pathway between BI and social anxiety. Read More

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http://dx.doi.org/10.1111/jcpp.13025DOI Listing
February 2019
1 Read

Special Education Teachers' Perceptions and Intentions Toward Data Collection.

J Early Interv 2018 Jun 27;40(2):177-191. Epub 2018 Apr 27.

University of Washington, Seattle, WA, USA.

Although data-based decision making is an evidence-based practice, many special educators have difficulty applying the practice within daily routines. We applied the Theory of Planned Behavior (TPB) to understand the influences that promote or hinder early childhood special educators' intentions to collect data. We assessed three influences on behavioral intention to collect data derived from the TPB: (a) attitude toward collecting data, (b) social norms for collecting data, and (c) perceived behavioral control for collecting data. Read More

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http://dx.doi.org/10.1177/1053815118771391DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6377170PMC

Relationship Conflict, Work Conditions, and the Health of Mothers With Young Children.

J Fam Issues 2018 Aug 28;39(12):3177-3202. Epub 2018 May 28.

The University of Texas at Austin, Austin, TX, USA.

Past research has shown that marital conflict is associated with poorer health among women and that new children come with declines in relationship quality and increased stress. The primary aim of this study was to explore how these two patterns converge-and what might buffer the risks of both to women's health. We do so by examining the potential for paid work, more often thought of as a stressor for women managing family roles and relationships, to help women weather tensions at home while raising young children. Read More

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Maternal pre-pregnancy obesity, offspring cord blood DNA methylation, and offspring cardiometabolic health in early childhood: an epigenome-wide association study.

Epigenetics 2019 Feb 18. Epub 2019 Feb 18.

b Center of Human Health and the Environment, North Carolina State University , Raleigh , 27695 , USA.

Pre-pregnancy obesity is an established risk factor for adverse sex-specific cardiometabolic health in offspring. Epigenetic alterations, such as in DNA methylation (DNAm), are a hypothesized link; however, sex-specific epigenomic targets remain unclear. Leveraging data from the Newborn Epigenetics Study (NEST) cohort, linear regression models were used to identify CpG sites in cord blood leukocytes associated with pre-pregnancy obesity in 187 mother-female and 173 mother-male offsprings. Read More

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http://dx.doi.org/10.1080/15592294.2019.1581594DOI Listing
February 2019

Survival from cancer in young people: An overview of late effects focussing on reproductive health.

Acta Obstet Gynecol Scand 2019 Feb 17. Epub 2019 Feb 17.

Leeds Institute of Health Research, School of Medicine and Health, University of Leeds, Leeds, UK.

This paper provides a summary of the areas of survival from childhood, teenage and young adult cancer and the significant late-effects that can arise from treatment with particular focus on the area of reproductive health and the impact on both fertility and pregnancy. To complete this review, Web of Science and MEDLINE were used. Search terms included: "survival AND childhood OR teenage OR young adult cancer", "late effects", "childhood cancer", "teenage and/or young adult cancer", "and fertility after cancer", "pregnancy after cancer" and "fertility preservation". Read More

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http://dx.doi.org/10.1111/aogs.13584DOI Listing
February 2019

Growth trajectories of breastfed HIV-exposed uninfected and HIV-unexposed children under conditions of universal maternal antiretroviral therapy: a prospective study.

Lancet Child Adolesc Health 2019 Feb 14. Epub 2019 Feb 14.

Division of Epidemiology and Biostatistics, University of Cape Town, Cape Town, South Africa; Centre for Infectious Disease Epidemiology and Research (CIDER), School of Public Health & Family Medicine, University of Cape Town, Cape Town, South Africa.

Background: Over 1 million HIV-exposed uninfected (HEU) children are born in sub-Saharan Africa annually. Little data exist on the risk of impaired growth in this population under current policies of universal maternal antiretroviral therapy (ART) with breastfeeding. We aimed to study the growth of breastfed HEU children born to women who initiated ART during pregnancy and compare their growth with that of breastfed HIV-unexposed (HU) children drawn from the same community. Read More

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http://dx.doi.org/10.1016/S2352-4642(19)30007-0DOI Listing
February 2019

Relationship of NEFA concentrations to RBP4 and to RBP4/retinol in prepubertal children with and without obesity.

J Clin Lipidol 2019 Jan 23. Epub 2019 Jan 23.

Lipid Metabolism Research Laboratory, IIS-Fundación Jiménez Díaz, Madrid, Spain.

Background: The regulation of adipose tissue metabolism in early childhood obesity is not well understood. Insulin levels are higher and insulin resistance seems to be present in prepubertal children with obesity but, differing from their behavior in adults with obesity, non-esterified fatty acid (NEFA) concentrations are not increased. Retinol-binding protein (RBP)-4 concentration is associated with obesity and insulin resistance conditions, but the means of this relationship remain unclear, and few studies have taken retinol values into account to evaluate it. Read More

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http://dx.doi.org/10.1016/j.jacl.2019.01.006DOI Listing
January 2019
1 Read

Risk factors for obesity among children aged 24 to 80 months in Korea: A decision tree analysis.

J Pediatr Nurs 2019 Feb 14. Epub 2019 Feb 14.

College of Nursing, Chung Cheong University, 38 Wolgok-Gil Gangnae-Myeon, Heungdeok-Gu, Cheongju-Si, Chungcheongbuk-Do 28171, South Korea. Electronic address:

Purpose: The purpose of this study was to examine the multiple intergenerational risk factors of obesity among children aged 24 to 80 months using national cohort data.

Design And Methods: This is a retrospective longitudinal cohort study using the Korean National Health Insurance (KNHI) database, and the number of study participants was 1,001,775 families. Social-Economic Status (SES), parental and child-related factors were examined. Read More

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http://dx.doi.org/10.1016/j.pedn.2019.02.004DOI Listing
February 2019

Bi-allelic Variants in TONSL Cause SPONASTRIME Dysplasia and a Spectrum of Skeletal Dysplasia Phenotypes.

Am J Hum Genet 2019 Feb 11. Epub 2019 Feb 11.

Department of Molecular and Human Genetics, Baylor College of Medicine, Houston, TX 77030, USA; Texas Children's Hospital, Houston, TX 77030, USA. Electronic address:

SPONASTRIME dysplasia is an autosomal-recessive spondyloepimetaphyseal dysplasia characterized by spine (spondylar) abnormalities, midface hypoplasia with a depressed nasal bridge, metaphyseal striations, and disproportionate short stature. Scoliosis, coxa vara, childhood cataracts, short dental roots, and hypogammaglobulinemia have also been reported in this disorder. Although an autosomal-recessive inheritance pattern has been hypothesized, pathogenic variants in a specific gene have not been discovered in individuals with SPONASTRIME dysplasia. Read More

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http://dx.doi.org/10.1016/j.ajhg.2019.01.007DOI Listing
February 2019

How do parents of school-aged children respond to their children's extending gestures?

J Child Lang 2019 Feb 18:1-21. Epub 2019 Feb 18.

University College London.

Gesture plays an important role in early language development, as how parents respond to their children's gestures may help to facilitate language acquisition. Less is known about whether parental responses facilitate language learning later in childhood and whether responses vary depending on children's language ability. This study explored parental responses to extending gestures in a sample of school-aged children (aged six to eight years) with developmental language disorder, low-language and educational concerns, and typically developing children. Read More

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http://dx.doi.org/10.1017/S0305000918000582DOI Listing
February 2019

[Choroidal thickness in preschool children].

Authors:
Z Kang H Yang

Zhonghua Yan Ke Za Zhi 2019 Feb;55(2):111-114

Xiamen Pediatric Hospital Affiliated to Fudan University, Xiamen Children's Hospital, Xiamen 361000, China.

To estimate the choroidal thickness (CT) in healthy children aged 2-6 years old and its relation to axial length, age and gender. Cross-sectional study. CT was assessed using spectral domain optical coherence tomography (OCT) in 126 children aged 2 to 6 years. Read More

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http://dx.doi.org/10.3760/cma.j.issn.0412-4081.2019.02.008DOI Listing
February 2019

Severe cryopyrin-associated periodic syndrome first characterized by early childhood-onset sensorineural hearing loss - Case report and literature review.

Int J Pediatr Otorhinolaryngol 2019 Jan 28;120:68-72. Epub 2019 Jan 28.

Division of Pediatric Rheumatology, Department of Pediatrics, IWK Health Centre, 5850/5980 University Ave, PO Box 9700, Halifax, NS, B3K 6R8, Canada. Electronic address:

Infant-onset bilateral sensorineural hearing loss is a key presenting symptom of the autoinflammatory cryopyrin-associated periodic syndrome. Other symptoms include periodic fever, cold-induced urticaria-like rash, chronic aseptic meningitis, polyarticular arthralgias, and renal AA amyloidosis. Early recognition and treatment with interleukin-1 blockade are critical for preventing disabling or fatal complications. Read More

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http://dx.doi.org/10.1016/j.ijporl.2019.01.037DOI Listing
January 2019

Income-related inequality and inequity in children's health care: A longitudinal analysis using data from Brazil.

Soc Sci Med 2019 Feb 4;224:127-137. Epub 2019 Feb 4.

Postgraduate Program in Epidemiology, Federal University of Pelotas, Brazil.

The Brazilian Unified Health System was created in the late 1980s to ensure free universal access to health care and was funded by taxes and social contributions. The persistent inequity in access to health services in favour of richer individuals in Brazil has been observed in the literature. However, to the best of our knowledge, no measurement of inequality in medicine use or private health insurance (PHI) among children has been performed with longitudinal data. Read More

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http://dx.doi.org/10.1016/j.socscimed.2019.01.040DOI Listing
February 2019

Acute Respiratory Illness in Rural Haiti.

Int J Infect Dis 2019 Feb 14. Epub 2019 Feb 14.

Emerging Pathogens Institute, University of Florida, Gainesville, FL, USA; Department of Health Services Research, Management and Policy, College of Public Health and Health Professions, University of Florida, Gainesville, FL. USA.

Objectives: Acute Respiratory Infection (ARI) is the most common cause of childhood morbidity and mortality in developing countries, including Haiti. Our objective was to detect pathogens found in children with ARI in rural Haiti to help develop evidence-based guidelines for treatment and prevention.

Methods: Retrospective study of students with ARI at four schools in rural Haiti. Read More

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http://dx.doi.org/10.1016/j.ijid.2019.02.003DOI Listing
February 2019

Effects of an Attachment-Based Intervention in Infancy on Children's Autonomic Regulation during Middle Childhood.

Biol Psychol 2019 Feb 14. Epub 2019 Feb 14.

Department of Psychological and Brain Sciences, University of Delaware, United States.

The present study used a longitudinal randomized clinical trial to test whether an early intervention has causal effects on children's autonomic nervous system regulation. When children were infants, parents involved with Child Protective Services received Attachment and Biobehavioral Catch-up (ABC; N = 43), an intervention that promotes sensitive parenting, or a control intervention (N = 53). When children were 9 years old, children whose parents had received ABC exhibited higher respiratory sinus arrhythmia and lower heart rate at rest and during a parent-child interaction than children in the control group. Read More

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http://dx.doi.org/10.1016/j.biopsycho.2019.01.006DOI Listing
February 2019

[Continuous spike-waves during slow-wave sleep: Experience during 20 years].

An Pediatr (Barc) 2019 Feb 13. Epub 2019 Feb 13.

Sección de Neuropediatría, Hospital Materno Infantil Gregorio Marañón, Madrid, España.

Introduction: Continuous spikes and waves during slow sleep (CSWS) is an EEG pattern that appears during childhood, and is often associated with cognitive impairment. It can appear in the course of epileptic syndromes, as well as in benign epilepsy. The aim of this study is to analyse epidemiological and clinical characteristic of patients with CSWS, in order to describe possible predictive factors in their outcome. Read More

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https://linkinghub.elsevier.com/retrieve/pii/S16954033193002
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http://dx.doi.org/10.1016/j.anpedi.2018.12.016DOI Listing
February 2019
1 Read

Positive Parenting Matters in the Face of Early Adversity.

Am J Prev Med 2019 Feb 14. Epub 2019 Feb 14.

Section of Developmental and Behavioral Pediatrics, Department of Pediatrics, University of Oklahoma Health Sciences Center, Oklahoma City, Oklahoma. Electronic address:

Introduction: A negative relationship between adverse childhood experiences and both physical and mental health in adulthood is well established, as is the positive impact of parenting on child development and future health. However, few studies have investigated unique influences of adverse childhood experiences and positive parenting together within a large, diverse early childhood sample.

Methods: The study used data on all children aged 0-5 years (n=29,997) from the National Survey of Children's Health 2011/2012 to examine effects of positive parenting practices and adverse childhood experiences on early childhood social-emotional skills and general development. Read More

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http://dx.doi.org/10.1016/j.amepre.2018.11.018DOI Listing
February 2019

[Early prevention and nutritional education].

Soins 2019 Jan - Feb;64(832):25-28

Institut Pasteur de Lille, 1, rue du professeur-Calmette, 59000 Lille, France. Electronic address:

To be effective, prevention must not remain a theoretical concept and its implementation must not be perceived negatively. Ignorance and prejudices need to be overcome. From conception to adolescence, simple and easy-to-follow nutritional education measures, as well as practical and concrete advice, can be easily applied. Read More

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http://dx.doi.org/10.1016/j.soin.2018.12.005DOI Listing
February 2019
1 Read

Prognostic effect of serum BDNF levels in late-life depression: Moderated by childhood trauma and SSRI usage?

Psychoneuroendocrinology 2019 Feb 7;103:276-283. Epub 2019 Feb 7.

University of Groningen, University Medical Center Groningen, Department of Psychiatry, University of Groningen PO Box 72, 9700 AB, Groningen, the Netherlands.

Background: Brain-derived neurotrophic factor (BDNF) levels decline during depression and normalise after remission, although studies in older patient samples are inconsistent. Whether BDNF serum levels predict depression remission is unclear. We hypothesize that the predictive value of serum BDNF levels in late-life depression is moderated by selective serotonin reuptake inhibitors (SSRI) usage and early traumatization. Read More

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http://dx.doi.org/10.1016/j.psyneuen.2019.02.003DOI Listing
February 2019

Complete Atrioventricular Septal Defect - Evolution of Results in a Single Center during 50 years.

Ann Thorac Surg 2019 Feb 13. Epub 2019 Feb 13.

Department of Pediatric Cardiac Surgery, Children's Hospital, Helsinki University Hospital, Helsinki University, Finland. Electronic address:

Background: Operative mortality after complete atrioventricular septal defect (cAVSD) repair has improved vastly. Less improvement has been demonstrated regarding late mortality and reoperation rates. There is evident lack of comprehensive population-based studies analyzing the history and progress of the ever-changing operative results. Read More

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http://dx.doi.org/10.1016/j.athoracsur.2019.01.020DOI Listing
February 2019

Genome-wide analysis of DNA methylation in relation to socioeconomic status during development and early adulthood.

Am J Phys Anthropol 2019 Feb 16. Epub 2019 Feb 16.

Child and Brain Development Program, Canadian Institute for Advanced Research, Toronto, Ontario, Canada.

Objectives: Socioeconomic status (SES) is a powerful determinant of health, but the underlying biological mechanisms are poorly understood. This study investigates whether levels of DNA methylation at CpG sites across the genome are associated with SES in a cohort of young adults in the Philippines.

Methods: DNA methylation was assayed with the Illumina HumanMethylation450 Bead Chip, in leukocytes from 489 participants in the Cebu Longitudinal Health and Nutrition Survey (mean age = 20. Read More

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http://dx.doi.org/10.1002/ajpa.23800DOI Listing
February 2019

Targeting angiogenesis in Duchenne muscular dystrophy.

Cell Mol Life Sci 2019 Feb 15. Epub 2019 Feb 15.

Department of Medical Biotechnology, Faculty of Biochemistry, Biophysics and Biotechnology, Jagiellonian University, Gronostajowa 7, 30-387, Kraków, Poland.

Duchenne muscular dystrophy (DMD) represents one of the most devastating types of muscular dystrophies which affect boys already at early childhood. Despite the fact that the primary cause of the disease, namely the lack of functional dystrophin is known already for more than 30 years, DMD still remains an incurable disease. Thus, an enormous effort has been made during recent years to reveal novel mechanisms that could provide therapeutic targets for DMD, especially because glucocorticoids treatment acts mostly symptomatic and exerts many side effects, whereas the effectiveness of genetic approaches aiming at the restoration of functional dystrophin is under the constant debate. Read More

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http://dx.doi.org/10.1007/s00018-019-03006-7DOI Listing
February 2019

Predictors of residential mobility and its impact on air pollution exposure among children diagnosed with early childhood leukemia.

J Expo Sci Environ Epidemiol 2019 Feb 15. Epub 2019 Feb 15.

Department of Epidemiology, Human Genetics and Environmental Sciences, Southwest Center for Occupational and Environmental Health, The University of Texas Health Science Center at Houston (UTHealth) School of Public Health, 1200 Pressler Street, Houston, TX, 77030, USA.

Epidemiology studies relying on one address to assign exposures over time share common methodological limitations in failing to account for mobility that may introduce potential exposure misclassification. Using Texas birth certificate and cancer registry data, we identified predictors of residential mobility among mothers of children diagnosed with early childhood leukemia in Texas from 1995 to 2011. We used U. Read More

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http://dx.doi.org/10.1038/s41370-019-0126-5DOI Listing
February 2019

Tracking of fruit, vegetables and unhealthy snacks consumption from childhood to adulthood (15 year period): does exposure to a free school fruit programme modify the observed tracking?

Int J Behav Nutr Phys Act 2019 Feb 15;16(1):22. Epub 2019 Feb 15.

Department of Public Health, Sport and Nutrition, University of Agder, Kristiansand, Norway.

Background: The rationale for promoting increased consumption of fruit and vegetables (FV) at an early age is based on results from previous tracking-studies, indicating that dietary habits learned in childhood sustain into adulthood. Previous tracking studies have several limitations (e.g. Read More

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http://dx.doi.org/10.1186/s12966-019-0783-8DOI Listing
February 2019

Exposure to a Slightly Sweet Lipid-Based Nutrient Supplement During Early Life Does Not Increase the Preference for or Consumption of Sweet Foods and Beverages by 4-6-y-Old Ghanaian Preschool Children: Follow-up of a Randomized Controlled Trial.

J Nutr 2019 Feb 15. Epub 2019 Feb 15.

Program in International and Community Nutrition, Department of Nutrition, University of California, Davis, CA.

Background: Whether consuming sweet foods early in life affects sweet food preferences and consumption later in childhood is unknown.

Objective: We tested the hypothesis that exposure to a slightly sweet lipid-based nutrient supplement (LNS) early in life would not increase preference for or consumption of sweet items at preschool age.

Methods: We followed up children who had participated in a randomized trial in Ghana in which LNS was provided to 1 group of women during pregnancy and 6 mo postpartum and to their infants from ages 6-18 mo (LNS group). Read More

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http://dx.doi.org/10.1093/jn/nxy293DOI Listing
February 2019

Changes in otitis media episodes and pressure equalization tube insertions among young children following introduction of the 13-valent pneumococcal conjugate vaccine: A birth-cohort based study.

Clin Infect Dis 2019 Feb 16. Epub 2019 Feb 16.

Department of Health Policy, Vanderbilt University Medical Center, Nashville, Tennessee, USA.

Introduction: The impact of 13-valent pneumococcal conjugate vaccine (PCV13) introduction on the occurrence of first and subsequent otitis media (OM) episodes in early childhood is unclear. We compared the risk of OM episodes among children age <2 years before and after PCV13 introduction accounting for the dependence between OM episodes.

Methods: We identified consecutive annual (July-June) cohorts of Tennessee Medicaid-enrolled children (2006-2014) from birth through age two years. Read More

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https://academic.oup.com/cid/advance-article/doi/10.1093/cid
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http://dx.doi.org/10.1093/cid/ciz142DOI Listing
February 2019
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Comparison of Sensitivities of American College of Rheumatology and Systemic Lupus International Collaborating Clinics Classification Criteria in Childhood-onset Systemic Lupus Erythematosus.

J Rheumatol 2019 Feb 15. Epub 2019 Feb 15.

From the Division of Rheumatology, The Hospital for Sick Children; Faculty of Medicine, University of Toronto; Translational Medicine, SickKids Research Institute, Toronto, Ontario, Canada. J.J. Tao, BSc, Division of Rheumatology, The Hospital for Sick Children, and Faculty of Medicine, University of Toronto, and Translational Medicine, SickKids Research Institute; L.T. Hiraki, MD, FRCPC, ScD, Division of Rheumatology, The Hospital for Sick Children, and Faculty of Medicine, University of Toronto, and Translational Medicine, SickKids Research Institute; D.M. Levy, MD, FRCPC, Division of Rheumatology, The Hospital for Sick Children, and Faculty of Medicine, University of Toronto, and Translational Medicine, SickKids Research Institute; E.D. Silverman, MD, FRCPC, Division of Rheumatology, The Hospital for Sick Children, and Faculty of Medicine, University of Toronto, and Translational Medicine, SickKids Research Institute. Address correspondence to Dr. E.D. Silverman, The Hospital for Sick Children, 555 University Ave., Toronto, Ontario M5G 1X8, Canada. E-mail: Accepted for publication October 4, 2018.

Objective: Currently there are 2 different classification criteria for systemic lupus erythematosus (SLE): American College of Rheumatology (ACR) and Systemic Lupus International Collaborating Clinics (SLICC). The aim of this study was to compare the sensitivities of ACR and SLICC criteria in childhood-onset SLE (cSLE) using a large, multiethnic cohort.

Methods: We conducted a retrospective study of 722 patients diagnosed with cSLE at The Hospital for Sick Children (SickKids). Read More

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http://dx.doi.org/10.3899/jrheum.180337DOI Listing
February 2019

What Do We Know about Diet and Markers of Cardiovascular Health in Children: A Review.

Int J Environ Res Public Health 2019 Feb 14;16(4). Epub 2019 Feb 14.

Department of Human Nutrition, University of Otago, Dunedin 9054, New Zealand.

Chronic diseases such as cancer, diabetes, and cardiovascular diseases (CVD) are the main health concerns in the 21st century, with CVD as the number one cause of mortality worldwide. Although CVD hard endpoints such as stroke or heart attack do not usually occur in children, evidence shows that the manifestation of CVD risk factors begins in childhood, preceding clinical complications of CVD in adulthood. Dietary intake is a modifiable risk factor that has been shown to make a substantial contribution to the risk of CVD in adulthood. Read More

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http://dx.doi.org/10.3390/ijerph16040548DOI Listing
February 2019
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Memory enhancements from active control of learning emerge across development.

Cognition 2019 Feb 12;186:82-94. Epub 2019 Feb 12.

Department of Psychology, University of California, Berkeley, United States.

This paper investigates whether active control of study leads to enhanced learning in 5- to 11-year-old children. In Experiments 1 and 2, participants played a simple memory game with the instruction to try to remember and later recognize a set of 64 objects. In Experiment 3, the goal was to learn the French names for the same objects. Read More

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http://dx.doi.org/10.1016/j.cognition.2019.01.010DOI Listing
February 2019

Hyperthyroidism Following Radiation Therapy for Childhood Cancer: A Report from the Childhood Cancer Survivor Study.

Int J Radiat Oncol Biol Phys 2019 Feb 12. Epub 2019 Feb 12.

Biostatistics Branch, Division of Cancer Epidemiology and Genetics, National Cancer Institute, NIH, DHHS, Bethesda, MD, USA.

Background: The association of hyperthyroidism with exposure to ionizing radiation is poorly understood. This study addresses the risk of hyperthyroidism in relation to incidental therapeutic radiation dose to the thyroid and pituitary glands in a large cohort of survivors of childhood cancer.

Methods: Utilizing the Childhood Cancer Survivor Study, a cohort of five-year survivors of childhood cancer diagnosed at hospitals in the United States and Canada between 1970 and 1986, the occurrence of hyperthyroidism through 2009 was ascertained among 12,183 survivors based on serial questionnaires. Read More

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https://linkinghub.elsevier.com/retrieve/pii/S03603016193020
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http://dx.doi.org/10.1016/j.ijrobp.2019.02.009DOI Listing
February 2019
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Considerations in multi-gene panel testing in pediatric ophthalmology.

J AAPOS 2019 Feb 12. Epub 2019 Feb 12.

National Eye Institute, National Institutes of Health, Bethesda, MD, 20892. Electronic address:

Multi-gene panel testing is used increasingly in ophthalmology practice as an efficient and cost-effective method for diagnosing inherited eye conditions. Panel testing is a powerful diagnostic tool, and it has the potential to reveal syndromic information in patients with seemingly isolated eye findings. This case series highlights our experience with 4 children in 3 families who were referred for evaluation of an isolated retinal degeneration and diagnosed with neuronal ceroid lipofuscinosis on panel testing. Read More

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http://dx.doi.org/10.1016/j.jaapos.2019.01.008DOI Listing
February 2019

Extrinsic and default mode networks in psychiatric conditions: Relationship to excitatory-inhibitory transmitter balance and early trauma.

Neurosci Biobehav Rev 2019 Feb 12;99:90-100. Epub 2019 Feb 12.

Department of Biological and Medical Psychology, University of Bergen, Bergen, Norway; Division of Psychiatry, Haukeland University Hospital, Bergen, Norway; Department of Radiology, Haukeland University Hospital, Bergen, Norway.

Over the last three decades there has been an accumulation of Magnetic Resonance Imaging (MRI) studies reporting that aberrant functional networks may underlie cognitive deficits and other symptoms across a range of psychiatric diagnoses. The use of pharmacological MRI and H-Magnetic Resonance Spectroscopy (H-MRS) has allowed researchers to investigate how changes in network dynamics are related to perturbed excitatory and inhibitory neurotransmission in individuals with psychiatric conditions. More recently, changes in functional network dynamics and excitatory/inhibitory (E/I) neurotransmission have been linked to early childhood trauma, a major antecedents for psychiatric illness in adulthood. Read More

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http://dx.doi.org/10.1016/j.neubiorev.2019.02.004DOI Listing
February 2019

Longitudinal Pathways From Shyness in Early Childhood to Personality in Adolescence: Do Peers Matter?

J Res Adolesc 2019 Feb 15. Epub 2019 Feb 15.

University of Oslo.

Temperamental shyness in childhood is theorized to be an important contributor for adolescent personality. However, empirical evidence for such pathways is scarce. Using longitudinal data (N = 939 children, 51% boys) across 17 years, the aim of this study was to examine how shyness development throughout childhood predicted personality traits in adolescence, and the role of peers in these associations. Read More

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http://dx.doi.org/10.1111/jora.12482DOI Listing
February 2019