60,516 results match your criteria Myoclonic Epilepsy Beginning in Infancy or Early Childhood


COVID-19 and children. From Luis Sepulveda to Madam Mim.

J Paediatr Child Health 2020 Jul 4. Epub 2020 Jul 4.

Microbiology Unit, Kingston Hospital NHS Foundation Trust, Kingston Upon Thames, UK.

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http://dx.doi.org/10.1111/jpc.15040DOI Listing

Impact of an extended postnatal home visiting programme on oral health among children in a disadvantaged area of Stockholm, Sweden.

Acta Paediatr 2020 Jul 4. Epub 2020 Jul 4.

Division of Orthodontics and Pediatric Dentistry, Department of Dental Medicine, Karolinska Institutet, Stockholm, Sweden.

Aim: To evaluate oral health outcomes and early oral health promotion of children in a Swedish, parental support programme conducted in a collaboration between Child Health Services and Social Services.

Methods: The intervention offered first-time parents six home visits from a paediatric nurse and a parental advisor with Social Services. On the fourth visit (infant age 6-8 months), parents received a toothbrush and fluoride toothpaste from non-dental staff. Read More

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http://dx.doi.org/10.1111/apa.15457DOI Listing

Social cohesion, depression, and substance use severity among young men: Cross-sectional and longitudinal analyses from a Swiss cohort.

Addict Behav 2020 Jun 15;110:106510. Epub 2020 Jun 15.

Department of Child and Adolescent Psychiatry and Psychotherapy, University Hospital of Psychiatry Zurich, University of Zurich, Zurich, Switzerland; La Source, School of Nursing Sciences, HES-SO University of Applied Sciences and Arts of Western Switzerland, Lausanne, Switzerland. Electronic address:

Introduction: Social cohesion, depression, and problematic substance use are intertwined and poorly understood.This study aimed to examine cross-sectional and longitudinal associations between social cohesion, depression and problematic substance use amongyoung men, age 21-25.

Methods: We used 2nd wave (t, 2012-2014, N = 6020) and 3rd wave (t, 2016-2018) data from the on-going Swiss CohortStudy on Substance Use Risk Factors (C-SURF), assessing social cohesion, depression, and severity of alcohol, nicotine and cannabis use during both waves. Read More

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http://dx.doi.org/10.1016/j.addbeh.2020.106510DOI Listing

"You have to find a caring man, like your father!" gendering sickle cell and refashioning women's moral boundaries in Sierra Leone.

Soc Sci Med 2020 Jun 29;259:113148. Epub 2020 Jun 29.

Department of Internal Medicine, College of Medicine and Allied Health Sciences, University of Sierra Leone, Freetown, Sierra Leone.

Most research on sickle cell disorders has tended to be gender-blind. This qualitative study undertaken in 2018, explores if and how sickle cell disorders become gendered in Sierra Leone through the analytical framework of a feminist ethics of care. It argues that women have to navigate moral blame when they have children with the condition. Read More

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http://dx.doi.org/10.1016/j.socscimed.2020.113148DOI Listing

Predictors of behavioral dysregulation and social dysfunction in pediatric patients with epilepsy and obesity: Developmental timing matters.

Epilepsy Behav 2020 Jul 1;111:107234. Epub 2020 Jul 1.

Neuropsychology Section in Department of Psychiatry; University of Michigan, Ann Arbor, 2101 Commonwealth Blvd. Suite C, Ann Arbor, MI 55455, United States of America.

Childhood obesity has been associated with greater risks of psychopathology, including externalizing behaviors and social dysfunction. However, there has been limited research on the effect of obesity on psychosocial functioning among pediatric patients with epilepsy. Accordingly, this study aimed to examine the association between overweight/obesity and behavioral and social functioning among pediatric patients with epilepsy, as function of their developmental status. Read More

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http://dx.doi.org/10.1016/j.yebeh.2020.107234DOI Listing

Validation of the Bullying Scale for Adults - Results of the PRONIA-study.

J Psychiatr Res 2020 May 11;129:88-97. Epub 2020 May 11.

Department of Psychiatry and Psychotherapy, Medical Faculty, Heinrich-Heine University, Düsseldorf, Germany.

Background: Bullying as a specific subtype of adverse life events is a major risk factor for poor mental health. Although many questionnaires on bullying are available, so far none covers bullying retrospectively throughout school and working life. To close this gap, the Bullying Scale for Adults (BSA) was designed. Read More

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http://dx.doi.org/10.1016/j.jpsychires.2020.04.004DOI Listing

Childhood obesity and cardiovascular disease risk: working towards solutions.

Can J Cardiol 2020 Jul 2. Epub 2020 Jul 2.

Department of Pediatrics, McMaster University, Hamilton, Ontario, Canada; Centre for Metabolism, Obesity, and Diabetes Research, McMaster University, Hamilton, Ontario, Canada. Electronic address:

The prevalence of obesity in childhood is high and continues to increase globally. It is currently estimated that 381 million children worldwide have overweight or obesity. This disease stems from multiple, complex pathways that can present early in life. Read More

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http://dx.doi.org/10.1016/j.cjca.2020.06.020DOI Listing

Long-term employment, education, and healthcare costs of childhood and adolescent onset of epilepsy.

Epilepsy Behav 2020 Jul 1:107256. Epub 2020 Jul 1.

VIVE - The Danish Center for Social Science Research, Copenhagen, Denmark. Electronic address:

Objective: Childhood- and adolescent-onset epilepsy may have a significant impact on long-term educational and vocational status, which in turn has consequences for individuals' socioeconomic status. We estimated the factual long-term socioeconomic consequences and healthcare costs of individuals with diagnosed epilepsy.

Methods: The prospective cohort study included Danish individuals with epilepsy onset before the age of 18 years, diagnosed between 2002 and 2016. Read More

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http://dx.doi.org/10.1016/j.yebeh.2020.107256DOI Listing

Parent-reported childhood temperament and adolescent self-reported substance use initiation.

Addict Behav 2020 Jun 10;110:106503. Epub 2020 Jun 10.

Florida State University, College of Medicine, United States.

Children differ in their general temperament and these differences predict consequential outcomes, including mental health, peer relations, and academic performance. In adults, there is strong evidence that personality correlates with substance use, but the temporal direction of the relation is unclear, as substance use may alter personality. The present research uses data from the Longitudinal Study of Australian Children (N = 5,362) to examine whether temperament assessed by parents in early childhood is associated with adolescent self-reported initiation of alcohol, cigarette, marijuana, or other drug use. Read More

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http://dx.doi.org/10.1016/j.addbeh.2020.106503DOI Listing

Use of Antibiotics in early Childhood and Dental Enamel Defects in 6- to 12-year-old Children in Primary Health Care.

Acta Odontol Latinoam 2020 Apr;33(1):6-13

Universidade Federal do Rio Grande do Sul, Programa de Pós-graduação em Odontologia, Rio Grande do Sul, Brasil.

Dental enamel defects (DED) are lesions that occur due several factors. Proper care is needed to promote their treatment and prevention. The aim of this study was to evaluate the occurrence of DED in permanent teeth of children who used antimicrobial drugs in the first four years of life. Read More

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Improving children's nutritional status in Cambodia: Multidimensional poverty and early integrated interventions.

Matern Child Nutr 2020 Jul 4:e12731. Epub 2020 Jul 4.

Maternal, Newborn and Child Health and Nutrition, United Nations Children's Fund (UNICEF), Phnom Penh, Cambodia.

One in three Cambodian children under 5 years of age are stunted. This study adopted a multidimensional approach to understand the influence of a series of contextual factors on the nutritional status of Cambodian children. In this study, we use a multidimensional poverty framework to identify a combination of interventions likely to achieve reductions in child stunting, in Cambodia. Read More

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http://dx.doi.org/10.1111/mcn.12731DOI Listing

Unravelling the role of epigenetics in reproductive adaptations to early-life environment.

Nat Rev Endocrinol 2020 Jul 3. Epub 2020 Jul 3.

Faculty of Biology, Technion-Israel Institute of Technology, Haifa, Israel.

Reproductive function adjusts in response to environmental conditions in order to optimize success. In humans, this plasticity includes age of pubertal onset, hormone levels and age at menopause. These reproductive characteristics vary across populations with distinct lifestyles and following specific childhood events, and point to a role for the early-life environment in shaping adult reproductive trajectories. Read More

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http://dx.doi.org/10.1038/s41574-020-0370-8DOI Listing

Early intervention service intensity and young children's home participation.

BMC Pediatr 2020 Jul 3;20(1):330. Epub 2020 Jul 3.

Rocky Mountain Human Services, Denver, USA.

Background: Young children with developmental disabilities and delays spend significant amounts of time at home, show decreased participation in home-based activities, and receive home-based early intervention services to improve participation in activities. Yet, knowledge about the relationship between EI service use and children's home participation in activities remains poorly understood but needed for program improvement. The purpose of this study was to understand the relationships between EI service use and children's home participation. Read More

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http://dx.doi.org/10.1186/s12887-020-02182-xDOI Listing

Early weaning alters redox status in the hippocampus and hypothalamus of rat pups.

Int J Dev Neurosci 2020 Jul 3. Epub 2020 Jul 3.

Programa de Pós-graduação em Ciências Biológicas: Bioquímica, ICBS, Universidade Federal do Rio Grande do Sul, Porto Alegre, RS, Brazil.

Exposure to environmental factors can program the metabolism, conferring resistance or increasing the risk to chronic diseases development in childhood and adulthood. In this sense, lactation is an important period in this window of development. Herein, we investigated the effect of early weaning on neurochemical and behavioral changes in offspring at weaning and adulthood. Read More

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http://dx.doi.org/10.1002/jdn.10047DOI Listing

Ayurveda in Early Life to Prevent Noncommunicable Diseases From Epigenetical Alterations.

Altern Ther Health Med 2020 Jul 1. Epub 2020 Jul 1.

Context: The incidence of non communicable disease (NCD) is rising globally and is currently the leading cause of mortality and morbidity worldwide. Some evidence suggests that factors affecting growth and development from the period of conception through fetal life to early childhood and adolescence are major risk determinants for NCD later in life. Among them, epigenetic changes are drawing attention and remain largely unexplored. Read More

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Sleep Through Toddlerhood: The Distinct Roles of Overall Media Use and Use of Media to Regulate Child Distress.

J Dev Behav Pediatr 2020 Jun 24. Epub 2020 Jun 24.

Department of Psychology, Ben-Gurion University of the Negev, Beer-Sheva, Israel.

Objective: Excessive media exposure has been associated with various sleep disturbances in early childhood. However, previous research mostly addressed the overall amount of media use while neglecting the role of media use practices. The purpose of this study was to examine whether media use practices (specifically, maternal use of media to regulate child distress) and overall media use predict distinct aspects of children's sleep. Read More

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http://dx.doi.org/10.1097/DBP.0000000000000836DOI Listing

Folliculocystic and Collagen Hamartoma: A Distinct Hamartoma Associated With Tuberous Sclerosis Complex.

Am J Dermatopathol 2020 Jun 30. Epub 2020 Jun 30.

Department of Dermatology, University of Puerto Rico School of Medicine, San Juan, PR.

Tuberous sclerosis complex (TSC) is a neurocutaneous disease characterized by cutaneous and extracutaneous hamartomas. Dermatologic evaluation is critical for early diagnosis because mucocutaneous manifestations account for 4 of 11 major and 3 of 6 minor diagnostic criteria. Folliculocystic and collagen hamartoma (FCCH) is a recently described entity associated with TSC. Read More

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http://dx.doi.org/10.1097/DAD.0000000000001720DOI Listing

Influence of pre-schooler and parent nutrition education on carotenoid levels of Mexican-heritage children.

Public Health Nutr 2020 Jun 19:1-9. Epub 2020 Jun 19.

University of California Cooperative Extension, Fresno County, CA, USA.

Objective: To determine the mediating effect of direct preschool and parent nutrition education on changes in skin carotenoids scores over 2 years in children of Mexican heritage.

Design: In a quasi-experimental, community-based study, two school districts were randomly assigned to either a comparison group (parent workshops unrelated to nutrition) or a childhood obesity prevention intervention group which included nutrition education at family nights for parents and at school for children. Changes in skin carotenoid intensity scores (diffCAROT, year 2015 minus 2013) were measured in children as a proxy for fruit and vegetable consumption using Resonance Raman Spectroscopy. Read More

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http://dx.doi.org/10.1017/S1368980019004579DOI Listing

Oral Health Knowledge, Attitudes and Behaviour of Parents and Caregivers of Preschool Children: Implications for Oral Health Promotion.

Oral Health Prev Dent 2020 Apr 1;18(2):245-252. Epub 2020 Apr 1.

Purpose: The aim of this study was to describe oral health knowledge, attitudes and behaviours of parents and caregivers of preschool children in order to inform an oral health promotion strategy.

Materials And Methods: A sample of parents and caregivers of children attending nine randomly selected preschools in central Trinidad were invited to complete a self-administered questionnaire on early childhood oral health.

Results: A total of 309 parents and caregivers participated: 88% were female, 74. Read More

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http://dx.doi.org/10.3290/j.ohpd.a43357DOI Listing

Young Adults with High Autistic-Like Traits Displayed Lower Food Variety and Diet Quality in Childhood.

J Autism Dev Disord 2020 Jul 2. Epub 2020 Jul 2.

School of Medical and Health Sciences, Edith Cowan University, 270 Joondalup Drive, Joondalup, WA, 6027, Australia.

This study explored the association between autistic-like traits in young adults and dietary intake in early childhood in the Gen2 Raine Study cohort. Data were available from 811 participants at years 1, 2 and 3 for the assessment of dietary intake, and at year 20 for measurement of autistic-like traits. Results showed as autistic-like traits increased, total food variety, core food variety and dairy variety decreased (p < 0. Read More

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http://dx.doi.org/10.1007/s10803-020-04567-4DOI Listing

Quantifying the Life-Cycle Benefits of an Influential Early-Childhood Program.

J Polit Econ 2020 Jul 21;128(7):2502-2541. Epub 2020 May 21.

Dornsife Center for Economic and Social Research University of Southern California 635 Downey Way Los Angeles, CA 90089

This paper quantifies and aggregates the multiple lifetime benefits of an influential high-quality early childhood program with outcomes measured through midlife. Guided by economic theory, we supplement experimental data with non-experimental data to forecast the life-cycle benefits and costs of the program. Our point estimate of the internal rate of return is 13. Read More

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http://dx.doi.org/10.1086/705718DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7331936PMC

Peripapillary hyperreflective ovoid mass-like structures-a novel entity as frequent cause of pseudopapilloedema in children.

Eye (Lond) 2020 Jul 2. Epub 2020 Jul 2.

Division of Ophthalmology, Tel Aviv Sourasky Medical Center, Tel Aviv, Israel.

Background: Optic nerve head drusen (ONHD) are considered the most common cause for pseudopapilloedema in children. We aimed to investigate and further characterize a new type of optic nerve head lesion on enhanced depth imaging optical coherence tomography (EDI-OCT) named peripapillary hyperreflective ovoid mass-like structures (PHOMS), and ONHD in asymptomatic children with pseudopapilloedema.

Methods: Retrospective cohort study including 64 eyes from 32 patients with pseudopapilloedema due to PHOMS and/or ONHD. Read More

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http://dx.doi.org/10.1038/s41433-020-1067-xDOI Listing

Relationship between childhood trauma and social adaptation in a sample of young people attending an early intervention service for psychosis.

Rev Psiquiatr Salud Ment 2020 Jun 29. Epub 2020 Jun 29.

Departamento de Salud Mental, Parc Taulí Hospital Universitari, Sabadell, Barcelona, España; Departamento de Psiquiatría y Medicina Legal, Universitat Autónoma de Barcelona, Cerdanyola del Vallés, Barcelona, España; Instituto de Investigación e Innovación Parc Taulí (I3PT), Sabadell, Barcelona, España; Centro de Investigación en Red de Salud Mental (CIBERSAM). Electronic address:

Introduction: Childhood trauma has been associated with an increased risk of psychosis, a greater severity of psychopathological symptoms, and a worse functional prognosis in patients with psychotic disorders. The current study aims to explore the relationship between childhood trauma, psychopathology and social adaptation in a sample of young people with first episode psychosis (FEP) or at-risk mental states (ARMS).

Material And Methods: The sample included 114 young people (18-35 years old, 81 FEP and 33 ARMS) who were attending an Early Intervention Service for Psychosis. Read More

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http://dx.doi.org/10.1016/j.rpsm.2020.05.001DOI Listing

Delay in Diagnosis of Two Siblings with Severe Ocular Problems and Autoimmune Polyglandular Syndrome.

Iran J Allergy Asthma Immunol 2020 Jun 23;19(3):313-317. Epub 2020 Jun 23.

Department of Allergy and Clinical Immunology, Children's Medical Center Hospital, Tehran University of Medical Sciences, Tehran, Iran AND Research Center for Immunodeficiencies, Tehran University of Medical Sciences, Tehran, Iran.

Autoimmune polyendocrine syndrome type 1 (APS1) is a scarce polyendocrinopathy with autosomal recessive inheritance results from defects in the human autoimmune regulatory (AIRE) gene. In addition to three major manifestations of APS1 including mucocutaneous candidiasis, hypoparathyroidism, and Addison's disease, ophthalmic problems such as keratoconjunctivitis, dry eye, iridocyclitis, and cataract can be seen in these patients. In this article, we introduced two siblings presented with nail dystrophia, severe photophobia, and keratitis since early childhood which genetic examination revealed single nucleotide T>C translocation in their 2nd exon and heterozygous deletion mutation in their 12th exon. Read More

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http://dx.doi.org/10.18502/ijaai.v19i3.3460DOI Listing

Maternal cigarette use during pregnancy and school readiness: An analysis of preschool age children in São Paulo, Brazil.

Early Hum Dev 2020 Jun 5;148:105103. Epub 2020 Jun 5.

Department of International Health, Johns Hopkins Bloomberg School of Public Health, 615 North Wolfe Street, Baltimore, MD 21205, United States of America.

Background: Barriers to early childhood development (ECD) are a global concern. Limited research exists on prenatal smoking and ECD in vulnerable populations, especially as it relates to school readiness (SR).

Aims: To examine how maternal cigarette use during pregnancy is associated with SR in a sample of Brazilian preschool-age children. Read More

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http://dx.doi.org/10.1016/j.earlhumdev.2020.105103DOI Listing

Voluntary pursuit of negatively valenced stimuli from childhood to early adulthood.

Dev Sci 2020 Jul 2:e13012. Epub 2020 Jul 2.

Department of Psychology and Center for Brain Science, Harvard University.

Although common sense suggests that we are motivated to pursue positive and avoid negative experiences, previous research shows that people regularly seek out negative experiences. In the current study, we characterized this tendency from childhood to young adulthood. Due to the known increases in risky behavior and sensation seeking in adolescence, we hypothesized that adolescents would show an increased engagement with negatively valenced stimuli compared to children and adults. Read More

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http://dx.doi.org/10.1111/desc.13012DOI Listing

History of breastfeeding but not mode of delivery shapes the gut microbiome in childhood.

PLoS One 2020 2;15(7):e0235223. Epub 2020 Jul 2.

University of Oregon, Eugene, OR, United States of America.

Background: The naïve neonatal gut is sensitive to early life experiences. Events during this critical developmental window may have life-long impacts on the gut microbiota. Two experiences that have been associated with variation in the gut microbiome in infancy are mode of delivery and feeding practices (eg, breastfeeding). Read More

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http://journals.plos.org/plosone/article?id=10.1371/journal.pone.0235223PLOS

Prenatal gestational diabetes mellitus exposure and accelerated offspring DNA methylation age in early childhood.

Epigenetics 2020 Jul 2. Epub 2020 Jul 2.

Department of Environmental Health Sciences, Mailman School of Public Health, Columbia University , New York, NY, USA.

Background: We investigated the association between prenatal GDM exposure and offspring DNA methylation (DNAm) age at 3-10 years of age in the Tianjin GDM Observational Study.

Methods: This study included 578 GDM and 578 non-GDM mother-child pairs. Children underwent a physical exam that included anthropometric measurements and a blood draw for DNAm analysis (Illumina 850K array) at a median age of 5. Read More

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http://dx.doi.org/10.1080/15592294.2020.1790924DOI Listing

Facilitators and barriers to completing recommended doses of pneumococcal vaccination among community-living individuals aged ≥65 years in Hong Kong - a population-based study.

Hum Vaccin Immunother 2020 Jul 2:1-10. Epub 2020 Jul 2.

Centre for Health Behaviours Research, JC School of Public Health and Primary Care, The Chinese University of Hong Kong , Hong Kong, China.

Individuals aged ≥65 y are recommended to receive pneumococcal vaccination (PV). PV completion is defined as receiving two doses of PV among those with at least one high-risk condition for severe invasive pneumococcal diseases (IPD) or receiving one dose of PV among those without any high-risk conditions. This study investigated factors associated with PV completion among a random sample of community-living older adults in Hong Kong, China. Read More

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http://dx.doi.org/10.1080/21645515.2020.1776545DOI Listing

The impact of adverse childhood experiences (ACEs) and combat exposure on mental health conditions among new post-9/11 veterans.

Psychol Trauma 2020 Jul 2. Epub 2020 Jul 2.

Henry M. Jackson Foundation for the Advancement of Military Medicine.

Objective: Adverse childhood experiences (ACEs) are early life experiences of abuse and neglect, and observed violence, among others. For military veterans, both ACEs and combat exposure are associated with mental health problems.

Method: This study examines the relationship between ACEs and combat exposure on the current mental health in a large sample of recent post-9/11 U. Read More

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http://dx.doi.org/10.1037/tra0000614DOI Listing

Contrasting impact of androgens on male and female adiposity, fat distribution and insulin resistance in childhood and adolescence (EarlyBird 75).

Pediatr Obes 2020 Jul 2:e12685. Epub 2020 Jul 2.

Faculty of Health, University of Plymouth, Plymouth, Devon, UK.

Objectives: To investigate associations between androgens (testosterone, dehydroepiandrosterone sulphate [DHEAS] and androstenedione), adiposity, fat distribution and insulin resistance (IR) during childhood and adolescence.

Methods: Three hundred and seven children (170 [55.4%] boys; 137 [44. Read More

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http://dx.doi.org/10.1111/ijpo.12685DOI Listing

Hurthle cell carcinoma in childhood: A retrospective analysis of five cases and review of pediatric literature.

Pediatr Blood Cancer 2020 Jul 2:e28300. Epub 2020 Jul 2.

Division of Pediatrics, Department of Human Pathology in Adulthood and Childhood, University of Messina, Messina, Italy.

Background: the available studies on Hurthle cell carcinoma (HCC) in pediatric age are scarce and based on isolated case reports. Aims of the present study were to review the available pediatric literature on HCC (2000-2019), to describe the cohort of children with this cancer histotype, and to estimate its relative prevalence in pediatric age.

Procedure: We retrospectively reconstructed an HCC course in five patients < 19 years who were identified in our departments during the period 2000-2019, and we reviewed the available pediatric studies on this differentiated thyroid cancer (DTC) variant. Read More

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http://dx.doi.org/10.1002/pbc.28300DOI Listing

The association between neurocognition and sexual abuse within a children's psychiatric inpatient program.

Clin Neuropsychol 2020 Jul 2:1-18. Epub 2020 Jul 2.

Department of Psychiatry & Human Behavior, E. P. Bradley Hospital, East Providence, RI, USA.

: The aim of this study was to understand the detrimental effects of sexual abuse on neuropsychological variables including child's intelligence, executive functioning (EF), and learning/memory within a pediatric inpatient population.: This study examined the effect of sexual abuse on children's intelligence, EF, and learning/memory by conducting a retrospective chart review for 144 children (aged 7-12) who completed a neuropsychological assessment during a psychiatric inpatient hospitalization. Of the 144 children, participants were matched two to one by gender and age, with one group (n = 52) categorized by reported sexual abuse and the other group (n = 92) categorized by no reported sexual abuse. Read More

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http://dx.doi.org/10.1080/13854046.2020.1781932DOI Listing

Using Item Response Theory to Compare Irritability Measures in Early Adolescent and Childhood Samples.

Assessment 2020 Jul 2:1073191120936363. Epub 2020 Jul 2.

Stony Brook University, Stony Brook, NY USA.

Limited psychometric information is available to guide best practices for measuring youth irritability. This report compares performance of irritability measures using item response theory (IRT). Study 1 used a sample of 482 early adolescents and compared the parent- and youth-report affective reactivity index (ARI) and irritability factors derived from the parent-report Child Behavior Checklist (CBCL) and clinician-administered Kiddie Schedule for Affective Disorders (K-SADS). Read More

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http://dx.doi.org/10.1177/1073191120936363DOI Listing

Microalbuminuria and Retinopathy in adolescents and young adults with type 1 and type 2 diabetes.

Pediatr Diabetes 2020 Jul 1. Epub 2020 Jul 1.

Division of Pediatrics, Department of Clinical Science, Intervention and Technology, Karolinska Institute, Stockholm, Sweden.

Aim: To estimate the occurrence of complications related to early-onset type 2 diabetes compared with type 1 diabetes.

Methods: All individuals registered in the Swedish Pediatric Quality Diabetes Register and the Swedish National Diabetes Register with type 2 diabetes diagnosis at 10-25 years of age between 1996 to 2014 (n = 1413) were included. As controls, individuals with type 1 diabetes were randomly selected from the same registers and were matched for age, sex and year-of-onset (n = 3748). Read More

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http://dx.doi.org/10.1111/pedi.13074DOI Listing

Lipid profile assessed in the family pediatrician's office: the COLIBRI'- SIMPeF study.

Eur J Pediatr 2020 Jul 2. Epub 2020 Jul 2.

School of Medicine and Surgery, University of Milano-Bicocca, Via Cadore 48, 20900, Monza, MB, Italy.

There is limited information on the prevalence of dyslipidemia in the Italian pediatric population. Aim of the study was to evaluate total cholesterol, high-density lipoprotein (HDL)-cholesterol and triglyceride levels, and associated factors in a large sample of Italian children, applying a micro-sampling procedure in the family pediatrician's office. In a population of 1910 children (50. Read More

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http://dx.doi.org/10.1007/s00431-020-03726-0DOI Listing

Differences in Compositions of Gut Bacterial Populations and Bacteriophages in 5-11 Year-Olds Born Preterm Compared to Full Term.

Front Cell Infect Microbiol 2020 16;10:276. Epub 2020 Jun 16.

Liggins Institute, University of Auckland, Auckland, New Zealand.

Preterm infants are exposed to major perinatal, post-natal, and early infancy events that could impact on the gut microbiome. These events include infection, steroid and antibiotic exposure, parenteral nutrition, necrotizing enterocolitis, and stress. Studies have shown that there are differences in the gut microbiome during the early months of life in preterm infants. Read More

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http://dx.doi.org/10.3389/fcimb.2020.00276DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7309444PMC

Recurrent angioedema, Guillain-Barré, and myelitis in a girl with systemic lupus erythematosus and CD59 deficiency syndrome.

Auto Immun Highlights 2020 Dec 29;11(1). Epub 2020 Jun 29.

Department of Pediatric Neurology, Mofid Children's Hospital, Shahid Beheshti University of Medical Sciences, Tehran, Iran.

Background: CD59 deficiency is a congenital mutation disorder in complement pathway which can present with various manifestations.

Case Presentation: Herein, we presented an adolescent 16-years-old girl with recurrent attacks of Guillain-Barre in early childhood and then recurrent attacks of angioedema, paresthesia, and myelitis. Finally, she presented with quadriplegia, malar rash, proteinuria, lymphopenia, and high titer of antinuclear antibody. Read More

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http://dx.doi.org/10.1186/s13317-020-00132-2DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7322911PMC
December 2020

Congenital proximal radioulnar synostosis-a case report.

Radiol Case Rep 2020 Aug 23;15(8):1313-1316. Epub 2020 Jun 23.

Limi Hospital, Abuja, Nigeria.

Congenital radioulnar synostosis is a rare anomaly of the forearm with restrictions of full movement of the affected limbs. It is often seen in early childhood when they present with functional impairments. A 10-year-old female with progressive difficulty with supination in both upper limbs seen in the OPD had bilateral forearm xray which showed bilateral proximal radioulnar synostosis. Read More

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http://dx.doi.org/10.1016/j.radcr.2020.05.070DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7321823PMC

Emotion Dysregulation and Early Trauma in Borderline Personality Disorder: An Exploratory Study.

Authors:
J Alafia M Manjula

Indian J Psychol Med 2020 May-Jun;42(3):290-298. Epub 2020 Apr 25.

Department of Clinical Psychology, Behavioral Medicine Unit, National Institute of Mental Health and Neuro Sciences, Bengaluru, Karnataka, India.

Background: Borderline personality disorder (BPD) research is in its nascent stage in India though studies have estimated its prevalence in psychiatric conditions. Trauma experiences and emotion regulation difficulties are well documented in BPD in the international literature. Thus, it is imperative to examine the role of trauma experiences and their relation to emotion dysregulation in BPD in the Indian context. Read More

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http://dx.doi.org/10.4103/IJPSYM.IJPSYM_512_18DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7320739PMC

Applying the Developmental Systems Approach to Inclusive Community-Based Early Intervention Programs: Process and Practice.

Infants Young Child 2020 Jul 26;33(3):173-183. Epub 2020 May 26.

Center on Human Development and Disability and Departments of Psychology and Pediatrics, University of Washington, Seattle.

A developmentally oriented framework is presented designed to establish or enhance the quality of inclusive community-based early intervention systems. This conceptually and empirically integrated developmental approach supports a comprehensive family-centered model. Outlined is a process that coordinates children's goals with family priorities, identifies developmental pathways most likely to influence those goals, guides the selection of objectives and intervention activities, and provides an approach for evaluation and problem solving. Read More

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http://dx.doi.org/10.1097/IYC.0000000000000167DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7289132PMC

Evaluation of antifungal activity of six children's toothpaste on isolated from early childhood caries patients.

J Indian Soc Pedod Prev Dent 2020 Apr-Jun;38(2):152-157

Department of Pediatric and Preventive Dentistry, Kannur Dental College, Kannur, Kerala, India.

Background: Early childhood caries (ECC) is an aggressive, destructive form of dental caries that affects the children younger than 6 years of age. Candida is known to increase the adherence of Streptococcus mutans to the oral biofilm and produce acids that cause tooth demineralization.

Aim Of The Study: To evaluate the efficacy of six commercially available children's toothpaste on clinical isolates of Candida albicans obtained from ECC patients. Read More

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http://dx.doi.org/10.4103/JISPPD.JISPPD_3_20DOI Listing

Association between early childhood caries and feeding practices among 3-5-year-old children of Indore, India.

J Indian Soc Pedod Prev Dent 2020 Apr-Jun;38(2):98-103

Departments of Public Health Dentistry, Sri Aurobindo College of Dentistry, Indore, Madhya Pradesh, India.

Background: The impact of early childhood caries (ECC) seen in infants and young children to the society is enormous. Most studies on ECC have been focused on specific ethnic and lower socioeconomic communities, however fewer studies are conducted in India as compared to other developed countries.

Aims: The study investigates the association between selected feeding practices and the presence of early ECC among 3-5 year-old children of Indore city. Read More

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http://dx.doi.org/10.4103/JISPPD.JISPPD_60_20DOI Listing

The Strengths and Difficulties Questionnaire is a usable way to address mental health at well-child visits in general practice - a qualitative study of feasibility.

BMC Fam Pract 2020 Jul 1;21(1):126. Epub 2020 Jul 1.

Department of Public Health, The Research Unit for General Practice and Section of General Practice, Faculty of Health Sciences, University of Copenhagen, Denmark, Copenhagen, Denmark.

Background: Mental health problems is frequent among children and psychopathology in early childhood seems to predict mental disorders in adulthood. All Danish children are offered seven free well-child visits at their General Practitioner (GP) during their first 5 years of life. GPs have a unique position to address mental health problems at the well-child visits, but they lack a systematic approach when assessing children's mental health. Read More

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http://dx.doi.org/10.1186/s12875-020-01156-3DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7329505PMC

Can Children Be Considered for Transradial Interventions?: Prospective Study of Sonographic Radial Artery Diameters.

Circ Cardiovasc Interv 2020 Jul 2;13(7):e009251. Epub 2020 Jul 2.

Department of Image Guided Therapy (A.A., W.H., S.B., A.A.D., K.B., P.M.), The Hospital for Sick Children, University of Toronto, ON, Canada.

Background: Transradial intervention is increasingly replacing approaches, due to lower access complications, cost, and improved patient satisfaction. There are limited supporting data in the pediatric literature, largely due to concerns regarding arterial size. The objective of this study was to measure radial artery diameters in children across all age groups, to establish reference ranges for clinical use. Read More

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http://dx.doi.org/10.1161/CIRCINTERVENTIONS.120.009251DOI Listing

Financing Maternity and Early Childhood Healthcare in The Australian Healthcare System: Costs to Funders in Private and Public Hospitals Over the First 1000 Days.

Int J Health Policy Manag 2020 May 12. Epub 2020 May 12.

Children's Hospital at Westmead Clinical School, Faculty of Medicine and Health, University of Sydney, Sydney, NSW, Australia.

Background: Maternity care is a significant contributor to overall healthcare expenditure, and private care is seen as a mechanism to reduce the cost to public funders. However, public funders may still contribute to part of the cost of private care. The paper aims to quantify (1) the cost to different funders of maternal and early childhood healthcare over the first 1000 days for both women giving birth in private and public hospitals; (2) any variation in cost to different funders by birth type; and (3) the cost of excess caesarean sections in public and private hospitals in Australia. Read More

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http://dx.doi.org/10.34172/ijhpm.2020.68DOI Listing

How to Intervene in the Caries Process in Children: A Joint ORCA and EFCD Expert Delphi Consensus Statement.

Caries Res 2020 Jul 1:1-9. Epub 2020 Jul 1.

Centre de Recherche en Odontologie Clinique EA 4847, UFR d'Odontologie, Département d'Odontologie Conservatrice, Université Clermont Auvergne, Clermont-Ferrand, France.

This paper provides recommendations for dentists for the treatment of dental caries in children, with an emphasis on early childhood caries (ECC), primary teeth, and occlusal surfaces in permanent teeth. A consensus workshop followed by an e-Delphi consensus process was conducted with an expert panel nominated by the European Organization for Caries Research (ORCA) and European Federation of Conservative Dentistry (EFCD)/German Association of Conservative Dentistry (DGZ) boards. Based on 3 systematic reviews and a nonsystematic literature search, recommendations were developed. Read More

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http://dx.doi.org/10.1159/000507692DOI Listing

Malnutrition, enamel defects, and early childhood caries in preschool children in a sub-urban Nigeria population.

PLoS One 2020 1;15(7):e0232998. Epub 2020 Jul 1.

School of Public Health, San Diego State University, San Diego, California, United States America.

Objectives: The study tried to determine if malnutrition (underweight, stunting, wasting, overweight) and enamel defects (enamel hypoplasia, hypomineralized second molar, amelogenesis imperfecta, fluorosis) were associated with early childhood caries (ECC). The study also examined whether malnutrition was associated with the presence of enamel defects in 0-5-year-old children.

Methods: The study was a secondary analysis of primary data of a cross-sectional study assessing the association between maternal psychosocial health and ECC in sub-urban Nigerian population collected in December 2018 and January 2019. Read More

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http://journals.plos.org/plosone/article?id=10.1371/journal.pone.0232998PLOS

Association of Parent-Reported Sleep Problems in Early Childhood With Psychotic and Borderline Personality Disorder Symptoms in Adolescence.

JAMA Psychiatry 2020 Jul 1. Epub 2020 Jul 1.

Institute for Mental Health, School of Psychology, University of Birmingham, Birmingham, United Kingdom.

Importance: Persistent nightmares in childhood have been prospectively associated with psychosis and borderline personality disorder (BPD) in adolescence. However, the extent to which this association is also true for behavioral sleep problems is still unknown, and the potential mechanisms are unexplored.

Objective: To examine the prospective associations between several parent-reported sleep problems in early childhood and psychotic and BPD symptoms at 11 to 13 years of age and the potential mediation of the associations by depression at 10 years of age. Read More

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http://dx.doi.org/10.1001/jamapsychiatry.2020.1875DOI Listing

Maternal microbiome regulation prevents early allergic airway diseases in mouse offspring.

Pediatr Allergy Immunol 2020 Jul 1. Epub 2020 Jul 1.

Department of Clinical Laboratory, The Second Hospital of Jilin University, Changchun, Jilin, 130041, People's Republic of China.

Background: Asthma is a serious global health problem, severely affecting the lives of sufferers and their families. An exceptionally hygienic home and reduced microbial exposure can aggravate the incidence of childhood asthma.

Methods: Specific-pathogen-free BALB/c mice were pretreated with bacterial lysate (BL; 1 mg/kg) as a high microbial load maternal mice model, then the offspring mice were established as an allergic airway disease (AAD) model. Read More

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http://dx.doi.org/10.1111/pai.13315DOI Listing