Search our Database of Scientific Publications and Authors

I’m looking for a

    18424 results match your criteria Myocarditis

    1 OF 369

    Clozapine-induced myocarditis.
    Oxf Med Case Reports 2018 Jan 9;2018(1):omx080. Epub 2018 Jan 9.
    Division of Cardiology, Department of Internal Medicine, The George Washington University, Washington, DC 20037, USA.
    Approved in 1989 for the management of treatment-resistant schizophrenia, Clozapine is a last-line atypical antipsychotic drug used with increasing frequency. In addition to its well-known side effect of agranulocytosis, this drug also carries with it rare but serious adverse cardiovascular risk of myocarditis. We present a patient on Clozapine who was admitted to the cardiology service with chest pain, ST segment elevations and elevated troponin concerning for acute myocardial infarction. Read More

    Catheter-based edge-to-edge mitral valve repair for pulmonary pressure reduction and to postpone heart transplantation in a teenaged patient.
    ESC Heart Fail 2018 Jan 18. Epub 2018 Jan 18.
    Clinical Division of Cardiology and Angiology, Innsbruck Medical University, Anichstrasse 35, 6020, Innsbruck, Austria.
    We report a case of catheter-based edge-to-edge mitral valve repair in a teenage male patient with non-ischaemic cardiomyopathy to improve pulmonary hypertension secondary to severe functional mitral regurgitation (FMR) to defer anticipated heart transplantation. A 19-year-old patient with previous history of fulminant myocarditis followed by markedly left ventricular dysfunction presented with severe mitral regurgitation 3 years after initial recovery. Slightly over time, deterioration of FMR was associated with gradual increase in pulmonary artery pressures despite optimal medical therapy. Read More

    Assessment of TSPO in a Rat Experimental Autoimmune Myocarditis Model: A Comparison Study between [18F]Fluoromethyl-PBR28 and [18F]CB251.
    Int J Mol Sci 2018 Jan 17;19(1). Epub 2018 Jan 17.
    Department of Nuclear Medicine, Seoul National University College of Medicine, Seoul National University Bundang Hospital, Seongnam 13620, Korea.
    Overexpression of the 18-kDa translocator protein (TSPO) is closely linked to inflammatory responses in the heart, including myocarditis, which can lead to myocardial necrosis. In vivo assessment of inflammatory responses has enabled the precise diagnosis of myocarditis to improve clinical outcomes. Here, we evaluated TSPO overexpression in a rat model of experimental autoimmune myocarditis (EAM) compared to healthy rats using two TSPO radiotracers, [18F]fluoromethyl-PBR28 ([18F]1) and [18F]CB251 ([18F]2). Read More

    Synthesis and anti-myocarditis activity in a multifunctional lanthanide microporous metal-organic framework with 1D helical chain building units.
    Braz J Med Biol Res 2018 Jan 11;51(3):e7050. Epub 2018 Jan 11.
    Department of Cardiology, Shenzhen University General Hospital, Shenzhen, Guangdong, China.
    A new microporous lanthanide metal-organic framework, {[Yb(BTB)(H2O) (DEF)2}n (1, DEF=N,N-Diethylformamide), with 1D nano-sized channels has been constructed by bridging helical chain secondary building units with 1,3,5-benzenetrisbenzoic acid (H3BTB) ligand. Structural characterization suggests that this complex crystallizes in the hexagonal space group P6122 and possesses 1D triangular channels with coordinated water molecules pointing to the channel center. In addition, anti-myocarditis properties of compound 1 were evaluated in vivo. Read More

    Systemic Loss of C-terminal Src Kinase Expression Elicits Spontaneous Suppurative Inflammation in Conditional Knockout Mice.
    Vet Pathol 2017 Jan 1:300985817747330. Epub 2017 Jan 1.
    1 Bristol-Myers Squibb, Princeton, NJ, USA.
    C-terminal Src kinase (Csk) is one of the critical negative regulators of the Src family of kinases. The Src family of kinases are nonreceptor tyrosine kinases that regulate inflammation, cell proliferation, motility, and adhesion. To investigate potential histologic lesions associated with systemic loss of Csk gene activity in adult mice, conditional Csk-knockout mice were examined. Read More

    Vegetative Valvular Endocarditis and Hepatitis Associated with Helcococcus ovis in a 7-year-old White Leghorn Rooster.
    Avian Dis 2017 Dec;61(4):526-530
    A University of California, Davis, California Animal Health & Food Safety Laboratory System.
    Helcococcus ovis is a slow-growing, pyridoxal-dependent, Gram-positive coccus belonging to the Peptostreptococcaceae family. Bacteria belonging to the genus Helcococcus are considered normal inhabitants of keratinized epithelium in humans; however, several reports support their role as pathogens in humans and several animal species. This case report describes the identification of H. Read More

    Ventricular Fibrillation following Varicella Zoster Myocarditis.
    Case Rep Cardiol 2017 23;2017:1017686. Epub 2017 Nov 23.
    University of Cyprus Medical School, Nicosia, Cyprus.
    Varicella-zoster virus (VZV) infection can rarely lead to serious cardiac complications and life-threatening arrhythmias. We present a case of a 46-year-old male patient who developed VZV myocarditis and presented with recurrent syncopal episodes followed by a cardiac arrest. He had a further collapse eight years later, and cardiac magnetic resonance imaging (MRI) demonstrated mild mid-wall basal and inferolateral wall fibrosis. Read More

    Role of Heart Rate Reduction in the Management of Myocarditis.
    Curr Pharm Des 2018 Jan 10. Epub 2018 Jan 10.
    Department of Cardiology, Second Affiliated Hospital and Yuying Children's Hospital of Wenzhou Medical University, Wenzhou 325000. China.
    The morbidity of myocarditis demonstrates an upward tendency by years, is commonly defined as the inflammation of myocytes and is caused by multiple factors. With the development of the molecular biological technique, great breakthroughs in the diagnosis and understanding of pathophysiological mechanisms of myocarditis have recently been achieved. Several questions remain unresolved, however, including standard treatment approaches to myocarditis, which remain controversial and ambiguous. Read More

    Lyme carditis with isolated left bundle branch block and myocarditis successfully treated with oral doxycycline.
    IDCases 2018 16;11:48-50. Epub 2017 Dec 16.
    Infectious Disease Division Winthrop-University Hospital Mineola, New York, United States.
    Lyme disease may present with a variety of cardiac manifestations ranging from first degree to third degree heart block. Cardiac involvement with Lyme disease may be asymptomatic, or symptomatic. Atrioventrical conduction abnormalities are the most common manifestation of Lyme carditis. Read More

    Cardiac Magnetic Resonance of Myocardial Involvement in Leptospirosis.
    Heart Views 2017 Oct-Dec;18(4):149-151
    Department of Radiology, Narayana Health, Bengaluru, Karnataka, India.
    Leptospirosis is a zoonotic infection caused by the Leptospira interrogans. Although it is endemic in tropical countries, global incidence has increased in several temperate and developed regions. Here, we present a cardiac magnetic resonance (CMR) and multidetector computer tomography (MDCT) chest features of active systemic leptospiral infection in a 19-year-old male. Read More

    [Related factors for the development of fulminant myocarditis in adults].
    Zhonghua Xin Xue Guan Bing Za Zhi 2017 Dec;45(12):1039-1043
    Department of Cardiology, Peking University Third Hospital, Key Laboratory of Cardiovascular Molecular Biology and Regulatory Peptides, Ministry of Health, Key Laboratory of Molecular Cardiovascular Sciences, Ministry of Education, Beijing 100191, China.
    Objective: To determine the early recognizable factors related to patients with fulminant myocarditis. Methods: Medical records from 60 adult patients who were diagnosed with acute viral myocarditis from January 2003 to September 2016 in our hospital were retrospectively reviewed, and divided into the fulminant group (n=9) and the non-fulminant group (n=51). Clinical presentations, biochemical markers, electrocardiography and echocardiography features on admission were analyzed. Read More

    Serological survey of neutralizing antibodies to eight major enteroviruses among healthy population.
    Emerg Microbes Infect 2018 Jan 10;7(1). Epub 2018 Jan 10.
    State Key Laboratory of Molecular Vaccinology and Molecular Diagnostics, School of Life Sciences, School of Public Health, Xiamen University, Xiamen, 361102, China.
    Human enteroviruses (EVs) are the most common causative agents infecting human, causing many harmful diseases, such as hand, foot, and mouth disease (HFMD), herpangina (HA), myocarditis, encephalitis, and aseptic meningitis. EV-related diseases pose a serious worldwide threat to public health. To gain comprehensive insight into the seroepidemiology of major prevalent EVs in humans, we firstly performed a serological survey for neutralizing antibodies (nAbs) against Enterovirus A71 (EV-A71), Coxsackie virus A16 (CV-A16), Coxsackie virus A6 (CV-A6), Coxsackie virus A10 (CV-A10), Coxsackie virus B3 (CV-B3), Coxsackie virus B5 (CV-B5), Echovirus 25 (ECHO25), and Echovirus 30 (ECHO30) among the healthy population in Xiamen City in 2016, using micro-neutralization assay. Read More

    Histological and morphometric analysis of dilated cardiomyopathy with special reference to collagen IV expression.
    Indian J Pathol Microbiol 2017 Oct-Dec;60(4):481-486
    Department of Pathology, All India Institute of Medical Sciences, New Delhi, India.
    Introduction: Collagen distribution alterations are well known in dilated cardiomyopathy. There are also changes in microvasculature along with other histomorphorphological features.

    Aims And Objectives: To study the histomorphological features of DCM along with their quantitative correlation with LVEF. Read More

    A Cross-sectional Study of Cardiovascular Involvement in Systemic Lupus Erythematosus in an Urban Indian Tertiary Care Centre with Emphasis on 2-D Echocardiography.
    J Assoc Physicians India 2017 Nov;65(11):59-64
    Associate Professor Medicine, TN Medical College and BYL Nair Charitable Hospital, Mumbai, Maharashtra.
    Background: Cardiovascular manifestations are responsible for considerable morbidity and mortality in patients with SLE. A wide range of manifestations due to active lupus, like pericarditis, valvular affection, myocarditis, and less commonly pulmonary hypertension, are described. This study was undertaken to study cardiovascular manifestations in SLE, with a focus on echocardiography findings, in an urban Indian setting. Read More

    A novel rat CVB1-VP1 monoclonal antibody 3A6 detects a broad range of enteroviruses.
    Sci Rep 2018 Jan 8;8(1):33. Epub 2018 Jan 8.
    Faculty of Medicine and Life Sciences, University of Tampere, Tampere, Finland.
    Enteroviruses (EVs) are common RNA viruses that cause diseases ranging from rash to paralytic poliomyelitis. For example, EV-A and EV-C viruses cause hand-foot and mouth disease and EV-B viruses cause encephalitis and myocarditis, which can result in severe morbidity and mortality. While new vaccines and treatments for EVs are under development, methods for studying and diagnosing EV infections are still limited and therefore new diagnostic tools are required. Read More

    An unusual flare of anti-synthetase syndrome during concurrent trastuzumab therapy given for recurrent breast cancer.
    Eur J Rheumatol 2017 Dec 25;4(4):278-280. Epub 2017 Oct 25.
    Department of Rheumatology and Bristol Interstitial Lung Disease Service, Southmead Hospital, Bristol, UK.
    We present the case of a patient with relapsing anti-synthetase syndrome (ASS) that may have been triggered by monoclonal antibody trastuzumab therapy given for breast cancer. A 52-year-old female with a history of anti-Jo1-associated ASS went into remission with glucocorticoids and mycophenolate mofetil. Her past history included invasive ductal carcinoma of the right breast that was fully treated six years prior to the onset of ASS. Read More

    Fulminant giant-cell myocarditis on mechanical circulatory support: Management and outcomes of a French multicentre cohort.
    Int J Cardiol 2018 Feb;253:105-112
    Medical Intensive Care Unit, iCAN, Institute of Cardiometabolism and Nutrition, Hôpital de la Pitié-Salpêtrière, Assistance Publique-Hôpitaux de Paris, Paris, France. Electronic address:
    Aims: Giant-cell myocarditis (GCM) is a rare and often fatal form of myocarditis. Only a few reports have focused on fulminant forms. We describe the clinical characteristics, management and outcomes of GCM patients rescued by mechanical circulatory support (MCS). Read More

    Non-rheumatic streptococcal myocarditis mimicking acute myocardial infarction in an adolescent male.
    Cardiol Young 2018 Jan 8:1-4. Epub 2018 Jan 8.
    1Department of Anesthesiology and Critical Care Medicine,Johns Hopkins School of Medicine,Baltimore,Maryland,United States of America.
    An adolescent male with a recent history of streptococcal pharyngitis presented with severe substernal chest pain, troponin leak, and ST-segment elevation, which are suggestive of acute inferolateral myocardial infarction. The coronary angiogram was normal. The patient was subsequently diagnosed with non-rheumatic streptococcal myocarditis. Read More

    The dynamic changes of myocardial collagen metabolism in experimental autoimmune myocarditis rats.
    Hellenic J Cardiol 2018 Jan 3. Epub 2018 Jan 3.
    Department of Geriatric Medicine, First Teaching Hospital of Tianjin University of Traditional Chinese Medcine, 314 an Shan Xi Road, Nan Kai District, Tianjin 300193, China. Electronic address:

    Lupus myocarditis receiving the rituximab therapy-a monocentric retrospective study.
    Clin Rheumatol 2018 Jan 3. Epub 2018 Jan 3.
    Section of Critical Care Medicine, Department of Internal Medicine, National Cheng Kung University Hospital, Tainan, Taiwan.
    Despite high-dose corticosteroids alone or with immunosuppressive agents as the standard therapy in lupus myocarditis (LM), an immune complex-mediated critical setting, such management is still associated with resistant disease and even mortality. A retrospective study was performed for the refractory LM patients treated with rituximab (RTX), a very limited experience in English literatures. A retrospective review of the myocarditis manifestation was carried out in hospitalized Han Chinese patients with SLE from February 2007 to January 2017. Read More

    Overall comparative analysis of management and outcomes of cardiac cases reported on board merchant ships.
    Int Marit Health 2017 ;68(4):190-195
    Med Solutions International, 57 West 57 St., 10019 NYC, United States.
    Background: Telemedical assistance has always been the cornerstone of medical care on board. Significant technological progress has provided improved scientific tools and equipment for high-quality communication and prompt management of either minor incidents or major emergencies on board. Med Solutions International is a medical management company, offering services exclusively to the maritime industry. Read More

    Vaccination with autologous myeloblasts admixed with GM-K562 cells in patients with advanced MDS or AML after allogeneic HSCT.
    Blood Adv 2017 Nov 14;1(24):2269-2279. Epub 2017 Nov 14.
    Department of Medical Oncology and Cancer Vaccine Center, Dana-Farber Cancer Institute, Boston, MA.
    We report a clinical trial testing vaccination of autologous myeloblasts admixed with granulocyte-macrophage colony-stimulating factor secreting K562 cells after allogeneic hematopoietic stem cell transplantation (HSCT). Patients with myelodysplastic syndrome (MDS) or acute myeloid leukemia (AML) with ≥5% marrow blasts underwent myeloblast collection before HSCT. At approximately day +30, 6 vaccines composed of irradiated autologous myeloblasts mixed with GM-K562 were administered. Read More

    Lyme disease presenting with facial palsy and myocarditis mimicking myocardial infarction.
    J Community Hosp Intern Med Perspect 2017 14;7(6):363-365. Epub 2017 Dec 14.
    Department of Cardiology, Easton Cardiovascular Associates, Easton, PA, USA.
    A 45-year-old woman presented with a sudden episode of typical chest pain, radiating to her neck. The patient denied premature coronary artery disease in the family. Initial EKG showed normal sinus rhythm with a 1 mm ST-elevation involving lead II and lead aVF and a 1 mm ST-depression in lead V1 with associated T-wave inversion. Read More

    The immunoproteasome-specific inhibitor ONX 0914 reverses susceptibility to acute viral myocarditis.
    EMBO Mol Med 2018 Jan 2. Epub 2018 Jan 2.
    Charité - Universitätsmedizin Berlin, corporate member of Freie Universität Berlin, Humboldt-Universität zu Berlin, and Berlin Institute of Health (BIH), Institute of Biochemistry, Berlin, Germany
    Severe heart pathology upon virus infection is closely associated with the immunological equipment of the host. Since there is no specific treatment available, current research focuses on identifying new drug targets to positively modulate predisposing immune factors. Utilizing a murine model with high susceptibility to coxsackievirus B3-induced myocarditis, this study describes ONX 0914-an immunoproteasome-specific inhibitor-as highly protective during severe heart disease. Read More

    Elevation of Serum APE1/Ref-1 in Experimental Murine Myocarditis.
    Int J Mol Sci 2017 Dec 8;18(12). Epub 2017 Dec 8.
    Division of Cardiology, Department of Internal Medicine, Chungnam National University Hospital, Chungnam National University School of Medicine, 282 Munhwa-ro, Jung-gu, Daejeon 35015, Korea.
    Myocarditis is an inflammatory disease of the myocardium that causes cardiogenic shock and death. However, endomyocardial biopsy that is, the gold standard for a diagnosis is limited. Apurinic/apyrimidinic endonuclease 1/redox effector factor-1 (APE1/Ref-1) is a multifunctional protein, which is involved in DNA-based excision repair pathway, and in redox signaling, its changes are observed in various cardiovascular diseases including hypertension and coronary artery disease. Read More

    Survey of rotavirus-associated severe complications in Aichi prefecture.
    Pediatr Int 2017 Dec 29. Epub 2017 Dec 29.
    Department of Pediatrics, Fujita Health University School of Medicine, Toyoake, Aichi, Japan.
    Background: Rotavirus can rarely cause severe complications such as encephalopathy/encephalitis, myocarditis, sudden unexpected death, urinary stone, and gastrointestinal bleeding; indeed incidence of these severe complications remains unclear. Additionally, it has not been determined whether rotavirus vaccine could reduce the cases with the severe complications or not.

    Method: A two-part questionnaire was designed to determine the number and clinical features of the cases with the severe complications between September 1st 2008 and August 31st 2015 including the observation periods before and after rotavirus vaccine introduction in Aichi prefecture. Read More

    Modulation of the IL-23/IL-17 axis by fenofibrate ameliorates the ovalbumin/lipopolysaccharide-induced airway inflammation and bronchial asthma in rats.
    Naunyn Schmiedebergs Arch Pharmacol 2017 Dec 30. Epub 2017 Dec 30.
    Department of Internal Medicine, Faculty of Medicine, Suez Canal University, Ismailia, 41522, Egypt.
    The overlapping between asthmatic subtypes, including both CD4+ T helper (TH)2 and TH17 cells, is found in the natural course of allergic asthma, especially in exacerbations and severe and insensitive forms to steroids, which are in need of new molecular therapies. In the TH2-subset mediated asthma, fenofibrate displays therapeutic promises, besides evidenced therapeutic effects on TH17-mediated colitis and myocarditis. Therefore, the effects of fenofibrate versus dexamethasone on IL-23/IL-17 axis in ovalbumin (OVA)/lipopolysaccharide (LPS)-induced airway inflammation and bronchial asthma in rats were explored. Read More

    Cardiac complications in diphtheria and predictors of outcomes.
    Int J Pediatr Otorhinolaryngol 2018 Jan 31;104:76-78. Epub 2017 Oct 31.
    Department of Cardiology, Sawai Man Singh Medical College and Attached Group of Hospitals, Jaipur, Rajasthan, India.
    Objective: To study the cardiac complications in diphtheria patients and to study the predictors of outcomes.

    Study Design: Single centre prospective analysis of cardiac complications in diphtheria patients.

    Results: In this study, there were 60 patients diagnosed with diphtheria with ECG changes. Read More

    Viral heart disease and acute coronary syndromes - often or rare coexistence ?
    Curr Pharm Des 2017 Dec 27. Epub 2017 Dec 27.
    Department of Invasive Cardiology, Central Clinical Hospital of Ministry of Internal Affairs, Warsaw. Poland.
    Background: Clinical presentation of viral myocarditis can mimic acute coronary syndrome and making diagnosis of viral heart disease (VHD) may be challenging. The presence of coronary artery disease (CAD) does not always exclude VHD and these entities can coexist. However, the incidence of co-occurrence of CAD and VHD is not precisely known. Read More

    Neospora caninum bioassay in gerbils using placental tissues from naturally infected goats.
    Vet Parasitol 2018 Jan 22;249:70-73. Epub 2017 Nov 22.
    Department of Veterinary Medicine, Federal University of Lavras, Lavras, Brazil.
    Neospora caninum is one of the main agents that causes abortions in cattle worldwide. However, little is known about the pathogenesis of neosporosis in small ruminants, especially goats. Gerbils (Meriones unguiculatus) have been used as a model for neosporosis, and this species is highly susceptible to infection by bovine N. Read More

    Risks of cardiovascular or central nervous system adverse events and immune reconstitution inflammatory syndrome, for dolutegravir versus other antiretrovirals: meta-analysis of randomized trials.
    Curr Opin HIV AIDS 2017 Dec 22. Epub 2017 Dec 22.
    St Stephens AIDS Trust, Chelsea and Westminster Hospital, London, UK.
    Purpose Of Review: Results from nonrandomized cohort studies suggest higher risks of CNS adverse events for dolutegravir, versus other ARVs. There have been two case reports of myocarditis on dolutegravir. Integrase inhibitors have been associated with IRIS in two cohort studies. Read More

    Return to work in heart failure patients with suspected viral myocarditis.
    SAGE Open Med 2017 12;5:2050312117744978. Epub 2017 Dec 12.
    Center for Rehabilitation Research, University of Potsdam, Potsdam, Germany.
    Background: Endomyocardial biopsy is considered as the gold standard in patients with suspected myocarditis. We aimed to evaluate the impact of bioptic findings on prediction of successful return to work.

    Methods: In 1153 patients (48. Read More

    Immune Checkpoint Inhibitor-Associated Myocarditis: A New Challenge for Cardiologists.
    Can J Cardiol 2018 Jan 16;34(1):92.e1-92.e3. Epub 2017 Oct 16.
    Department of Oncology, Geneva University Hospitals and Medical Faculty, Geneva, Switzerland.
    The ever-increasing use of immune checkpoint inhibitors in cancer is leading to a high incidence of autoimmune side effects. This report discusses an autoimmune fulminant myocarditis in an elderly patient with metastatic pulmonary adenocarcinoma in whom the most advanced invasive heart failure therapies were used successfully. She was treated with nivolumab. Read More

    Integration of miRNA and gene expression profiles suggest a role for miRNAs in the pathobiological processes of acute Trypanosoma cruzi infection.
    Sci Rep 2017 Dec 21;7(1):17990. Epub 2017 Dec 21.
    Laboratory of Immunology, Heart Institute (InCor), University of São Paulo School of Medicine, São Paulo, Brazil.
    Chagas disease, caused by the parasite Trypanosoma cruzi, is endemic in Latin America. Its acute phase is associated with high parasitism, myocarditis and profound myocardial gene expression changes. A chronic phase ensues where 30% develop severe heart lesions. Read More

    Changes in serum cardiac myosin light chain 1 levels in children with fulminant myocarditis during continuous blood purification.
    Rev Assoc Med Bras (1992) 2017 Oct;63(10):904-909
    Pediatric Intensive Care Unit (PICU), The First Hospital of Jilin University, Changchun, Jilin, China.
    Objective: To investigate the changes in serum cardiac myosin light chain 1 (CMLC-1) levels in children with fulminant myocarditis (FM) during continuous blood purification (CBP), as well as to analyze its correlation with other laboratory indexes.

    Method: Twenty-four (24) children with FM who underwent CBP were enrolled. Before and during treatment (48 and 72 hours after treatment, or death), the optical density value of serum CMLC-1 was measured using enzyme-linked immunosorbent assay, and then the serum CMLC-1 concentration was calculated. Read More

    Plasma Long Non-Coding RNA (lncRNA) GAS5 is a New Biomarker for Coronary Artery Disease.
    Med Sci Monit 2017 Dec 21;23:6042-6048. Epub 2017 Dec 21.
    Department of Cardiology, The First People's Hospital of Tianmen, Tianmen, Hubei, China (mainland).
    Our study aimed to investigate the diagnostic value of long non-coding RNA (lncRNA) GAS5 for coronary artery disease (CAD) and to explore the mechanism of the role of GAS5 in CAD. A total of 30 patients with CAD were selected from January 2015 to January 2017 in The First Hospital of Tianmen. In addition, 30 healthy individuals were selected as a control group, and patients with various other types of cardiovascular diseases were also selected. Read More

    Adiponectin attenuates profibrotic extracellular matrix remodeling following cardiac injury by up-regulating matrix metalloproteinase 9 expression in mice.
    Physiol Rep 2017 Dec;5(24)
    Department of Cardiology, Charité University Medicine Berlin, Campus Benjamin Franklin, Berlin, Germany
    Adiponectin (APN) is a multifunctional adipocytokine that inhibits myocardial fibrosis, dilatation, and left ventricular (LV) dysfunction after myocardial infarction (MI). Coxsackievirus B3 (CVB3) myocarditis is associated with intense extracellular matrix (ECM) remodeling which might progress to dilated cardiomyopathy. Here, we investigated in experimental CVB3 myocarditis whether APN inhibits adverse ECM remodeling following cardiac injury by affecting matrix metalloproteinase (MMP) expression. Read More

    [The virus-immune hypothesis for cardiac dilatation].
    Ter Arkh 2017 ;89(11):79-83
    Siberian State Medical University, Ministry of Health of Russia, Tomsk, Russia.
    The paper gives an update on the pathogenetic role of viral infection and immune mechanisms in the development of cardiac dilatation at the cellular, ultrastructural, and molecular levels. Particular attention is given to the discussion of the possible role of herpesvirus infection in the mechanisms of cardiomyocyte damage with the direct or indirect impact of viral infection through immunoinflammatory responses. Data on the protective and damaging action of a number of cytokines in the immunopathogenesis of viral myocarditis are considered. Read More

    Continuation with clozapine after eosinophilia: a case report.
    Ann Gen Psychiatry 2017 14;16:46. Epub 2017 Dec 14.
    Department of Psychiatry, Chang-Gung Memorial Hospital at Linkuo, Taoyuan City, Taiwan.
    Background: Clozapine-induced eosinophilia had been reported in several studies about blood dyscrasias in clozapine-treated patient. The largest study with 2404 patients in Italy found the incidence of 2.2% by criteria of more than 0. Read More

    PD-1 modulates radiation-induced cardiac toxicity through cytotoxic T lymphocytes.
    J Thorac Oncol 2017 Dec 13. Epub 2017 Dec 13.
    Department of Radiation Oncology, Thomas Jefferson University, 111 South 11th Street Philadelphia, PA 19107. Electronic address:
    Introduction: Combined immune checkpoint blockade has led to rare autoimmune complications, such as fatal myocarditis. Recent approvals of several anti-PD1 drugs for lung cancer treatment prompted ongoing clinical trials that directly combine PD-1 inhibitors with thoracic radiotherapy for locally advanced lung cancer. Overlapping toxicities from either modality have the potential to increase the risk for radiation-induced cardiotoxicity (RICT), which is well documented among patients with HD and breast cancer. Read More

    Interleukin-13 reduces cardiac injury and prevents heart dysfunction in viral myocarditis via enhanced M2 macrophage polarization.
    Oncotarget 2017 Nov 10;8(59):99495-99503. Epub 2017 Aug 10.
    Department of Cardiology, Zhengzhou University People's Hospital, Zhengzhou 450001, China.
    Viral myocarditis is one of the major causes of congestive heart failure and dilated cardiomyopathy. Recent reports have demonstrated an essential role of cytokines, like interleukin-13 (IL-13), in the pathogenesis of viral myocarditis, while the underlying mechanisms remain poorly defined. Here, using a coxsackie virus B3 (CVB3)-infection model in BALB/C mice, we showed that IL-13 protected mouse heart function in viral myocarditis, seemingly through reduction in T lymphocyte immunity and induction of M2 macrophage polarization. Read More

    Atherosclerosis and cardiovascular involvement in celiac disease: the role of autoimmunity and inflammation.
    Eur Rev Med Pharmacol Sci 2017 Dec;21(23):5437-5444
    Department of Internal and Emergency Medicine, Catholic University of the Sacred Heart, School of Medicine, Rome, Italy.
    Objective: The aim of this review is to explore the evidence about the association among celiac disease (CD), atherosclerosis (AS) and cardiovascular (CV) diseases, and the role of inflammation in this connection.

    Materials And Methods: A systematic literature search was conducted using PubMed, EMBASE, and Cochrane Library for the association among CD, AS and CV diseases.

    Results: Several studies reported the association of CD with accelerated AS, as evidenced by the alterations of a number of parameters indicative of subclinical AS, as increased carotid artery intima-media thickness, endothelial dysfunction and increased arterial stiffness. Read More

    Transient Myocardial Thickening in Cats Associated with Heart Failure.
    J Vet Intern Med 2017 Dec 15. Epub 2017 Dec 15.
    Royal Veterinary College, University of London, Hatfield, UK.
    Background: Cats with hypertrophic cardiomyopathy (HCM) and congestive heart failure (CHF) can have resolution of both left ventricular hypertrophy and CHF.

    Objectives: To describe the clinical characteristics of cats with transient myocardial thickening (TMT) and CHF compared with a control population of cats without resolution of HCM.

    Animals: A total of 21 cats with TMT, 21 cats with HCM. Read More

    1 OF 369