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J Med Cases 2020 Jul 29;11(7):207-210. Epub 2020 Jun 29.

Department of Medical and Surgical Specialties, Institute of Cardiology, University of Brescia, Italy.

Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) is mainly responsible for respiratory involvement but cardiac complications are also reported. Nevertheless, potential life-threatening conditions in young people have not been described. A 19-year-old male autistic patient was admitted with fever and cough. Read More

J Med Cases 2020 Dec 21;11(12):375-378. Epub 2020 Oct 21.

Evidence-Based Medicine Department, Hospital Pediatrico de Sinaloa, Culiacan, Mexico.

We report four cases of patients with multisystem inflammatory syndrome in children (MIS-C) associated with severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infection, of which three patients presented characteristics of Kawasaki disease (KD). All presented fever of more than 3 days, and gastrointestinal involvement, significant increase in C-reactive protein (CRP), polymorphonuclear cells, procalcitonin, D-dimer, fibrinogen and troponin, lymphopenia and hypoalbuminemia. Myocardial involvement was observed in two patients. Read More

Curr Atheroscler Rep 2021 May 13;23(7):37. Epub 2021 May 13.

Department of Medicine, Johns Hopkins University School of Medicine, Baltimore, MD, USA.

Purpose Of Review: Coronavirus disease 2019 (COVID-19) has been the cause of significant global morbidity and mortality. Here, we review the literature to date of the short-term and long-term consequences of Severe Acute Respiratory Syndrome Coronavirus-2 (SARS-CoV-2) infection on the heart.

Recent Findings: Early case reports described a spectrum of cardiovascular manifestations of COVID-19, including myocarditis, stress cardiomyopathy, myocardial infarction, and arrhythmia. Read More

Eur Heart J Case Rep 2021 May 5;5(5):ytab168. Epub 2021 May 5.

Department of Cardiology, Kettering General Hospital, NHS, Rothwell Road, Kettering, NN16 8UZ, UK.

Background: Myocardial infarction (MI) with non-obstructive coronary arteries presenting with ST-segment elevation can be challenging. Understanding the cardiac and non-cardiac causes aid in identifying the underlying diagnosis and deciding on the management. Neurological insult resulting in a mismatch of oxygen supply or demand to cardiomyocytes can lead to type 2 MI. Read More

Front Pharmacol 2021 26;12:658273. Epub 2021 Apr 26.

Department of Zoology, School of Basic and Applied Sciences, Central University of Punjab, Bathinda, India.

After gaining entry through ACE2 aided by TMPRSS2, the SARS-CoV-2 causes serious complications of the cardiovascular system leading to myocarditis and other myocardial injuries apart from causing lung, kidney and brain dysfunctions. Here in this review, we are going to divulge the cellular and immunological mechanisms behind the cardiovascular, thrombotic and platelet impairments that are caused in COVID-19. In addition, we also propose the significance of various anti-platelet and anti-thrombotic phytochemicals in the treatment of COVID-19. Read More

Circ J 2021 May 13. Epub 2021 May 13.

Department of Emergency and Critical Care Medicine, Shinshu University School of Medicine.

Background: Multisystem inflammatory syndrome in children (MIS-C) is a rare syndrome temporally related to severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2). MIS-C shares similarities with Kawasaki disease, but left ventricular dysfunction is more common in MIS-C.Methods and Results:This study reports the case of a 16-year-old Japanese male patient with MIS-C. Read More

Cancer Med 2021 May 12. Epub 2021 May 12.

Division of Public Health, Department of Family & Preventive Medicine, University of Utah School of Medicine, Salt Lake City, UT, USA.

Introduction: Young cancer survivors may be at increased risk of early-onset chronic health conditions. The aim of this population-based study is to estimate cardiovascular disease (CVD) risk among younger versus older B-cell non-Hodgkin's lymphoma (B-NHL) survivors compared with their respective general population cohorts.

Methods: B-NHL survivors diagnosed from 1997 to 2015 in the Utah Cancer Registry were matched with up to five cancer-free individuals on birth year, sex, and birth state, using the statewide Utah Population Database. Read More

High Alt Med Biol 2021 May 11. Epub 2021 May 11.

Division of Pulmonary and Critical Care Medicine, Intermountain Medical Center and the University of Utah, Salt Lake City, Utah, USA.

Luks, Andrew M. and Colin K. Grissom. Read More

Sao Paulo Med J 2021 May 10. Epub 2021 May 10.

MD, PhD. Full Professor, Cardiovascular Surgery Division, Instituto do Coracao, Hospital das Clinicas HCFMUSP, Faculdade de Medicina, Universidade de Sao Paulo, Sao Paulo, SP, BR; and Cardiovascular Surgeon, Hospital Sírio Libanês (HSL), São Paulo (SP), Brazil.

Context: Heart failure in Brazil is a major public health problem and, even with advances in treatment, it still presents high morbidity and mortality. As a treatment option, mechanical circulatory assist devices (MCADs) have greatly increased in importance over the last decade.

Case Report: This report concerns a case of refractory cardiogenic shock due to acute myocarditis in a 35-year-old puerperal female patient who presented with retrosternal pain, fatigue and dyspnea. Read More

Acta Cardiol Sin 2021 May;37(3):296-304

Graduate Institute of Clinical Medicine, National Taiwan University Hospital and Medical College, National Taiwan University, Taiwan e Administration of National Health Insurance, Taipei, Taiwan.

Background: The epidemiology of pediatric potentially sudden death (SD) events and the rescue rate remain unclear.

Methods: We established a birth cohort (2000-2014) from a national database 2000-2015.

Results: Of 3,097,277 live births, we identified 3126 children (56. Read More

JACC Cardiovasc Imaging 2021 May 5. Epub 2021 May 5.

Barts Heart Centre, Barts Health NHS Trust, West Smithfield, London, United Kingdom; Institute of Cardiovascular Science, University College London, London, United Kingdom. Electronic address:

Objectives: The purpose of this study was to detect cardiovascular changes after mild severe acute respiratory syndrome coronavirus 2 infection.

Background: Concern exists that mild coronavirus disease 2019 may cause myocardial and vascular disease.

Methods: Participants were recruited from COVIDsortium, a 3-hospital prospective study of 731 health care workers who underwent first-wave weekly symptom, polymerase chain reaction, and serology assessment over 4 months, with seroconversion in 21. Read More

Am J Med Sci 2021 May 8. Epub 2021 May 8.

Mayo Clinic Department of Cardiovascular Medicine, Scottsdale, Arizona.

Immune checkpoint inhibitor (ICI) monoclonal antibody drugs are an important interface of immunology and cancer biology with the intended goal to create cancer specific treatments with less systemic toxicity. Recognition of immune-related adverse events is critical and these include significant cardiovascular toxicity and myocarditis. Compared with other immune-related events, ICI associated myocarditis is rare but is associated with high mortality. Read More

Int J Surg Case Rep 2021 Apr 27;83:105926. Epub 2021 Apr 27.

Department of Cardiology, Mohamed First University, Faculty of Medicine and Pharmacy, Oujda, Morocco; Laboratory of Epidemiology and Clinical Research, Faculty of Medicine and Pharmacy, Oujda, Morocco.

Introduction: Myocardial infarction is usually due to thrombotic occlusion of a coronary vessel caused by rupture of a vulnerable atherosclerosis plaque. There is also the acute myocardial infarction with no evidence of relevant stenosis of the coronary artery, known as myocardial infarction with non-obstructive coronary arteries (MINOCA) such as Takotsubo, myocarditis and catecholamine induced cardiomyopathy. Pheochromocytoma is one of the causes of MINOCA. Read More

Circulation 2021 05 10;143(19):1926-1928. Epub 2021 May 10.

Division of Pediatric Cardiology, Department of Pediatrics (B.S.H., J.V.C., J.N.J., R.R.P.), University of Tennessee Health Sciences Center, Memphis.

J Investig Allergol Clin Immunol 2021 May 10. Epub 2021 May 10.

Allergy Service, University Hospital of Salamanca, Salamanca, Spain.

Radiol Cardiothorac Imaging 2021 Apr 4;3(2):e200628. Epub 2021 Mar 4.

Department of Diagnostic and Interventional Radiology, University Hospital Bonn, Venusberg-Campus 1, 53127 Bonn, Germany (J.A.L., A.I., N.M., M.R., A.F., D.D., U.A.); Quantitative Imaging Lab Bonn (QILaB) (J.A.L., A.I., N.M., M.R., A.F., D.D.); Department of Internal Medicine II - Cardiology, University Hospital Bonn, Venusberg-Campus 1, 53127 Bonn, Germany (C.O., S.Z.); Department of Internal Medicine I, University Hospital Bonn, Venusberg-Campus 1, 53127 Bonn, Germany (M.M., S.S., C.B., C.P.S., J.N.); Department of Internal Medicine III-Oncology, University Hospital Bonn, Venusberg-Campus 1, 53127 Bonn, Germany (A.H.); Department of Anesthesiology, University Hospital Bonn, Venusberg-Campus 1, 53127 Bonn, Germany (M.V.); Department of Cardiac Surgery, University Hospital Bonn, Venusberg-Campus 1, 53127 Bonn, Germany (G.D.D.).

COVID-19; coronavirus; myocarditis; cardiac MRI; T1 mapping; T2 mapping. Read More

Front Cardiovasc Med 2021 23;8:652746. Epub 2021 Apr 23.

Laboratory of Metabolomics, Jiangsu Key Laboratory of Drug Metabolism and Pharmacokinetics, China Pharmaceutical University, Nanjing, China.

Myocardial infarction (MI) is one of the leading causes of death worldwide, and knowing the early warning signs of MI is lifesaving. To expand our knowledge of MI, we analyzed plasma metabolites in MI and non-MI chest pain cases to identify markers for alerting about MI occurrence based on metabolomics. A total of 230 volunteers were recruited, consisting of 146 chest pain patients admitted with suspected MI (85 MIs and 61 non-MI chest pain cases) and 84 control individuals. Read More

Front Pediatr 2021 23;9:644922. Epub 2021 Apr 23.

Lakes Region General Hospital, Laconia, NH, United States.

Pediatric myocarditis is a rare disease. The etiologies are multiple. Mortality associated with the disease is 5-8%. Read More

Neurol Clin Pract 2021 Feb;11(1):e46-e47

Burden Professor of Clinical Neurosciences (NJS), University of Bristol and Southmead Hospital, Bristol, United Kingdom; Consultant Pathologist (HA), United Kingdom; Professor of Cardiovascular Pathology (MS), Department of Cardiovascular Pathology, St George's Medical School, University of London, United Kingdom; and Director of Transplant and Consultant Cardiac Surgeon (ARS), Royal Brompton and Harefield NHS Foundation Trust, Harefield Hospital, Harefield, Middlesex, United Kingdom.

Cardiol Young 2021 May 10:1-5. Epub 2021 May 10.

Kütahya Health Sciences University, Department of Pediatric Cardiology, Kütahya, Turkey.

Background: Platelet indices are used to evaluate platelet activation and function which change in inflammatory diseases. We hypothesise that platelet indices such as plateletcrit, mean platelet volume, and platelet distribution width may be more useful as prognostic indicators for myopericarditis in children.

Methods: A total of 60 children were included in this study. Read More

Ir J Med Sci 2021 May 7. Epub 2021 May 7.

Council of Forensic Medicine, Istanbul, Turkey.

Background: Although the lung is seen as the main target organ affected by SARS-CoV-2, other organs are also damaged.

Aim: We aimed to determine the extrapulmonary findings of autopsies performed on cases with positive results with postmortem polymerase chain reaction test.

Methods: Pathological changes in extrapulmonary organs were examined with light microscopy. Read More

Ann Cardiol Angeiol (Paris) 2021 May 4. Epub 2021 May 4.

Service de médecine interne, Hôpital Mongi Slim La Marsa, Tunis, Tunisia.

Diagnosis of pheochromocytoma can be simple when classic manifestations are present. It can also be challenging and complicated in some cases because of its wide array of faces and presentations. We present a case of a 30-year-old female patient who came with acute respiratory distress, chest pain, hemoptysis, asthenia, anorexia, weight loss of 20kg, and paresthesia in her lower limbs. Read More

Inflammation 2021 May 7. Epub 2021 May 7.

Department of Cardiology, The First Affiliated Hospital of Guangxi Medical University, 6 Shuangyong Road, Nanning, 530021, People's Republic of China.

Viral myocarditis (VMC) is the major cause of sudden death in adolescents. To date, no effective treatment has been identified for VMC. Studies have shown that T helper (Th) cells such as Th1, Th2, Th17, and Th22 cells are involved in the pathogenesis of VMC. Read More

Curr Cardiol Rep 2021 May 7;23(6):58. Epub 2021 May 7.

Cardiothoracovascular Department, Azienda Sanitaria Universitaria Giuliano Isontina (ASUGI) and University of Trieste, Via Valdoni 7, 34129, Trieste, Italy.

Purpose Of Review: Myocarditis is a polymorphic disease, both in its presentation and clinical course. Recent data suggests that the genetic background, interacting with environmental factors, could be diriment both in the susceptibility and evolution of myocarditis in different clinical presentations. The aim of this paper is to expose the current available evidences and the evolving concepts on this topic, in order to provide insight for improving the clinical management of those patients. Read More

Anatol J Cardiol 2021 May;25(5):313-322

Department of Pediatric Cardiology, University of Health Sciences, İstanbul Mehmet Akif Ersoy Thoracic and Cardiovascular Surgery Training and Research Hospital; İstanbul-Turkey.

Objective: Pediatric ventricular tachycardias (VTs) have heterogeneous etiology and different clinical features. This study aimed to evaluate the clinical spectrum and long-term course of pediatric sustained VTs.

Methods: Patients diagnosed as having sustained VT between 2010 and 2020 were evaluated retrospectively. Read More

Herzschrittmacherther Elektrophysiol 2021 May 6. Epub 2021 May 6.

The Heart Center and University of Nairobi, Nairobi, Kenia.

We report the case of a pregnant woman with complete heart block during her first trimester who presented with dyspnea at the East African Heart Rhythm Project in Nairobi. There was no evidence of an acute cause (e.g. Read More

Cureus 2021 Apr 1;13(4):e14250. Epub 2021 Apr 1.

Department of Cardiology, McLaren Health Care, Flint/Michigan State University, Flint, USA.

Acute myocarditis is commonly caused by viral infections resulting from viruses such as adenovirus, enteroviruses, and, rarely, coronavirus. It presents with nonspecific symptoms like chest pain, dyspnea, palpitation, or arrhythmias and can progress to dilated cardiomyopathy or heart failure. Fulminant myocarditis is a potentially life-threatening form of the condition and presents as acute, severe heart failure with cardiogenic shock. Read More

Proc (Bayl Univ Med Cent) 2021 Jan 22;34(3):401-402. Epub 2021 Jan 22.

Department of Cardiology, Trinity Health of New England, Hartford, Connecticut.

Giant cell myocarditis (GCM) usually affects previously healthy adults and is a rapidly progressive and frequently fatal disease. It has a median survival of 3 months to death or transplant without appropriate therapy. Hence, early diagnosis is critical, with evidence showing rapidly instituted cyclosporine-based immunosuppression can improve transplant-free survival. Read More

Cardiovasc Revasc Med 2021 Apr 15. Epub 2021 Apr 15.

Weill Cornell Medicine Qatar, Qatar Foundation, Education City, Al, Luqta St. Ar-Rayyan, P.O. Box 24144, Doha, Qatar. Electronic address:

Coronavirus disease 2019(COVID-19) is an ongoing global pandemic with a daily increasing number of affected individuals and a relatively high mortality rate. COVID-19 patients that develop cardiac injury are at increased risk of a worse clinical course with higher rates of mortality. Increasing amounts of evidence suggest that a system-wide inflammatory response and a cytokine storm mediated type syndrome plays a crucial role in disease progression. Read More

Circ Cardiovasc Imaging 2021 May 5:CIRCIMAGING120012177. Epub 2021 May 5.

Department of Diagnostic Radiology, Yokohama City University Graduate School of Medicine, Kanagawa, Japan (S.K., M.K., D.U.).