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    Myocardial performance index in active and inactive paediatric systemic lupus erythematosus.
    Clin Exp Rheumatol 2017 Feb 3. Epub 2017 Feb 3.
    Department of Paediatrics, Faculty of Medicine, Ramathibodi Hospital, Mahidol University Bangkok, Thailand.
    Objectives: To evaluate cardiac structure and function in paediatric SLE patients without clinical evidence of cardiovascular disease in active and inactive diseases.

    Methods: Patients aged ≤20 years who fulfilled the diagnostic criteria of active SLE underwent transthoracic echocardiography to evaluate cardiac structure and function, and were then followed up echocardiographically every 3-4 months until SLE disease was inactive. Patients with heart failure, myocarditis, pericarditis, endocarditis, coronary artery disease, or abnormal structural heart disease were excluded. Read More

    Characterization of normal and scarred myocardium based on texture analysis of cardiac computed tomography images.
    Conf Proc IEEE Eng Med Biol Soc 2016 Aug;2016:4161-4164
    An accurate detection of myocardial scar using Cardiac CT may have a strong clinical impact; however, the main drawback is the insufficient contrast to noise ratio of delayed iodine enhanced (DIE) CT images, which makes its accurate segmentation (manual as well as automatic) difficult. In this work, we investigate texture parameters applied on the different scans in order to obtain the scans and features that best differentiates normal from scarred myocardium. The experiments on 7 cases of myocarditis show the accuracy of the parameter energy in all scans, as well as the good performance of the angiographic scan (having higher spatial resolution) with different parameters for the segmentation propose. Read More

    Predictors of acute myocarditis in complicated scrub typhus: an endemic province in the Republic of Korea.
    Korean J Intern Med 2017 Feb 23. Epub 2017 Feb 23.
    Division of Cardiology, Eulji University Hospital, Daejeon, Korea.
    Background/aims: Scrub typhus is known as a self-limited infectious disease. Cardiac complication is uncommon and usually not life-threatening. Until now, few cases of fulminant myocarditis by scrub typhus have been reported. Read More

    Cardiovascular Toxicities Associated with Cancer Immunotherapies.
    Curr Cardiol Rep 2017 Mar;19(3):21
    Divisions of Oncology, Department of Medicine, Vanderbilt University Medical Center, 2220 Pierce Ave, 777 Preston Research Bldg., Nashville, TN, 37232, USA.
    Purpose Of Review: We review the cardiovascular toxicities associated with cancer immune therapies and discuss the cardiac manifestations, potential mechanisms, and management strategies.

    Recent Findings: The recent advances in cancer immune therapy with immune checkpoint inhibitors and adoptive cell transfer have improved clinical outcomes in numerous cancers. The rising use of cancer immune therapy will lead to a higher incidence in immune-related adverse events. Read More

    Interpretation of cardiac wall motion from cine-MRI combined with parametric imaging based on the Hilbert transform.
    MAGMA 2017 Feb 20. Epub 2017 Feb 20.
    University of Tunis El Manar, Higher Institute of Medical Technologies of Tunis, Laboratory of Biophysics and Medical Technology, Tunis, Tunisia.
    Object: The aim of this study was to test and validate the clinical impact of parametric amplitude images obtained using the Hilbert transform on the regional interpretation of cardiac wall motion abnormalities from cine-MR images by non-expert radiologists compared with expert consensus.

    Materials And Methods: Cine-MRI short-axis images obtained in 20 patients (10 with myocardial infarction, 5 with myocarditis and 5 with normal function) were processed to compute a parametric amplitude image for each using the Hilbert transform. Two expert radiologists blindly reviewed the cine-MR images to define a gold standard for wall motion interpretation for each left ventricular sector. Read More

    Effects of exercise therapy on polymyositis complicated by post-myocarditis cardiomyopathy: A case report.
    J Rehabil Med 2017 Feb 16. Epub 2017 Feb 16.
    Department of Cardiovascular Rehabilitation, National Cerebral and Cardiovascular Center, Osaka, Japan.
    Background: A 42-year-old woman with chronic polymyositis complicated by post-myocarditis cardiomyopathy underwent supervised and unsupervised exercise therapy with staged increases in intensity.

    Methods: Supervised exercise therapy, which included adopted standards for patients with heart failure, was performed for 6 months. After one month, unsupervised exercise therapy was commenced, in the form of 15 min walking, the duration of which was increased to 30 min after 2 months. Read More

    Why Edema Is a Matter of the Heart.
    Circ Cardiovasc Imaging 2017 Feb;10(2)
    From the Departments of Medicine and Diagnostic Radiology, McGill University, Montréal, Québec, Canada; Department of Medicine, Heidelberg University, Germany; Département de radiologie, Université de Montréal, Montréal, Québec, Canada; and Departments of Cardiac Sciences and Radiology, University of Calgary, Canada.

    Detection and Monitoring of Acute Myocarditis Applying Quantitative Cardiovascular Magnetic Resonance.
    Circ Cardiovasc Imaging 2017 Feb;10(2)
    From the Working Group Cardiovascular Magnetic Resonance, Experimental and Clinical Research Center, a joint cooperation between the Charité Medical Faculty and the Max-Delbrueck Center for Molecular Medicine; and HELIOS Klinikum Berlin Buch, Department of Cardiology and Nephrology, Germany (F.v.K.-B., J.S., S.D., A.R., J.S.-M.); Clinic Agatharied, Department of Cardiology, Ludwig-Maximilians-University Munich, Hausham, Germany (F.v.K.-B.); Siemens Healthcare, Erlangen, Germany (M.A.D., A.G.); National Institute of Health, Bethesda, MD (P.K.); and German Center for Cardiovascular Research (DZHK), partner site Berlin, Germany (J.S.-M.).
    Background: Cardiovascular magnetic resonance based on the Lake Louise Criteria is used to make the diagnosis of acute myocarditis. Novel quantitative parametric mapping techniques promise to overcome some of its limitations. We aimed to evaluate quantitative cardiovascular magnetic resonance to detect and monitor acute myocarditis. Read More

    Infant acute myocarditis mimicking acute myocardial infarction.
    Autops Case Rep 2016 Oct-Dec;6(4):15-19. Epub 2016 Dec 30.
    Department of Legal Medicine - Farhat Hached University Hospital, Sousse - Tunisia .
    Myocarditis is an inflammatory disease of the myocardium with heterogeneous clinical manifestations and progression. In clinical practice, although there are many methods of diagnosis of acute myocarditis, the diagnosis remains an embarrassing dilemma for clinicians. The authors report the case of 9-month-old infant who was brought to the Pediatric Emergency Department with sudden onset dyspnea. Read More

    Clozapine-induced hypersensitivity myocarditis presenting as sudden cardiac death.
    Autops Case Rep 2016 Oct-Dec;6(4):9-13. Epub 2016 Dec 30.
    Division of Cardiovascular Medicine - Department of Medicine - University of Missouri School of Medicine, Columbia/MO, USA .
    Hypersensitivity myocarditis is a rare but serious adverse effect of clozapine, a commonly used psychiatric drug. We report the case of sudden cardiac death from clozapine-induced hypersensitivity myocarditis diagnosed at autopsy. A 54-year-old Caucasian male on clozapine therapy for bipolar disorder presented with a sudden onset of shortness of breath. Read More

    IL-37 ameliorates coxsackievirus B3-induced viral myocarditis by modulating the Th17/Treg immune response.
    J Cardiovasc Pharmacol 2017 Feb 14. Epub 2017 Feb 14.
    1Health cardiovascular department, Shandong Provincial Hospital affiliated to Shandong University 2Department of Cardiology, Rizhao People's Hospital.
    Myocarditis is a heterogeneous group of disorders defined by inflammation of the heart muscle with an excessively activated immune response. Numerous interventions have been investigated for the treatment of myocarditis while success is limited. Interleukin-37 (IL-37), a novel member of the IL-1 cytokine family, is a natural inhibitor of innate immunity associated with autoimmune diseases. Read More

    Transcriptome analysis reveals dynamic changes in coxsackievirus A16 infected HEK 293T cells.
    BMC Genomics 2017 Jan 25;18(Suppl 1):933. Epub 2017 Jan 25.
    National Engineering Laboratory for AIDS Vaccine, School of Life Sciences, Jilin University, Changchun, 130012, China.
    Background: Coxsackievirus A16 (CVA16) and enterovirus 71 (EV71) are two of the major causes of hand, foot and mouth disease (HFMD) world-wide. Although many studies have focused on infection and pathogenic mechanisms, the transcriptome profile of the host cell upon CVA16 infection is still largely unknown.

    Results: In this study, we compared the mRNA and miRNA expression profiles of human embryonic kidney 293T cells infected and non-infected with CVA16. Read More

    Association Between Dehydration and Fever During the First Week of Life.
    Clin Pediatr (Phila) 2017 Feb 1:9922816687323. Epub 2017 Feb 1.
    1 CHU Sainte-Justine, Montreal, Quebec, Canada.
    Background: Trying to differentiate serious bacterial infection (SBI) from a self-limiting illness in febrile infants seen in the pediatric emergency department (PED) is a significant challenge. The aim of the study was to determine the prevalence of dehydration and its relationship to SBI in febrile full-term newborns under 1 week of age seen in a PED.

    Methods: A retrospective observational study was carried out on all children younger than 8 days of age with fever who presented to a single, tertiary care, PED from January 2009 to April 2014. Read More

    Diagnostic Approach to Myocarditis Mimicking Myocardial Infarction at Initial Presentation.
    Cardiol Res 2016 Dec 31;7(6):209-213. Epub 2016 Dec 31.
    St John Hospital and Medical Center, Wayne State University School of Medicine, Detroit, MI, USA; University of Alabama at Birmingham (UAB) Medical Center, Birmingham, Alabama, AL, USA; Birmingham Veterans Affairs Medical Center, Birmingham, AL, USA.
    We present a case of a 35-year-old male patient with a 12-hour history of sudden-onset, crushing chest pain and associated complaints of profuse diaphoresis, nausea and vomiting. The patient was transferred to our institution from an outside hospital for evaluation and possible emergent catheterization. Left heart catheterization was conclusive for normal coronary arteries and a ventriculogram revealed a left ventricular ejection fraction of approximately 45%. Read More

    Right Cervical Vagotomy Aggravates Viral Myocarditis in Mice Via the Cholinergic Anti-inflammatory Pathway.
    Front Pharmacol 2017 31;8:25. Epub 2017 Jan 31.
    Department of Cardiology, Second Affiliated Hospital of Wenzhou Medical University Wenzhou, China.
    The autonomic nervous system dysfunction with increased sympathetic activity and withdrawal of vagal activity may play an important role in the pathogenesis of viral myocarditis. The vagus nerve can modulate the immune response and control inflammation through a 'cholinergic anti-inflammatory pathway' dependent on the α7-nicotinic acetylcholine receptor (α7nAChR). Although the role of β-adrenergic stimulation on viral myocarditis has been investigated in our pervious studies, the direct effect of vagal tone in this setting has not been yet studied. Read More

    Coxsackie Myocarditis and Hepatitis with Reactivated Epstein-Bar Virus (EBV): A Case Report.
    Am J Case Rep 2017 Feb 15;18:166-169. Epub 2017 Feb 15.
    Department of Internal Medicine, University of Nebraska Medical Center, Omaha, NE, USA.
    BACKGROUND Myocarditis, defined as inflammation of myocardial tissue of the heart, is an uncommon cardiac presentation and is due to a variety of causes. It affects 1% of the US population, 50% of which is caused by coxsackie B virus. Cardiac tissue is the prime target, and destruction of myocardium results in cardiac failure with fluid overload. Read More

    Detection of human parvovirus B19 DNA in 22% of 1,815 cutaneous biopsies of a wide variety of dermatologic conditions suggests viral persistence after primary infection and casts doubts on its pathogenic significance.
    Br J Dermatol 2017 Feb 14. Epub 2017 Feb 14.
    Department of Dermatology, Hospital Universitario Fundación Jiménez Díaz/Universidad Autónoma de Madrid, Madrid, Spain.
    Background: Human parvovirus B19 (B19V) has been associated with a number of dermatologic and systemic conditions, including myocarditis and autoimmune syndromes.

    Objectives: To determine the frequency of B19V deoxyribonucleic acid (DNA) detection in a large dermatopathology practice, and to characterize the histopathologic patterns involved.

    Methods: We selected for polymerase chain reaction (PCR) detection of B19V a total of 1,815 skin biopsies pertaining to entities allegedly related to Parvovirus B19, as well as cases suspected clinically of representing paraviral exanthemas. Read More

    Dilated cardiomyopathy.
    Lancet 2017 Feb 9. Epub 2017 Feb 9.
    St Vincent's Hospital, Sydney, NSW, Australia; Victor Chang Cardiac Research Institute, Sydney, NSW, Australia.
    Dilated cardiomyopathy is defined by the presence of left ventricular dilatation and contractile dysfunction. Genetic mutations involving genes that encode cytoskeletal, sarcomere, and nuclear envelope proteins, among others, account for up to 35% of cases. Acquired causes include myocarditis and exposure to alcohol, drugs and toxins, and metabolic and endocrine disturbances. Read More

    Mesenchymal Stromal Cells Modulate Monocytes Trafficking in Coxsackievirus B3-Induced Myocarditis.
    Stem Cells Transl Med 2017 Jan 3. Epub 2017 Jan 3.
    Berlin-Brandenburg Center for Regenerative Therapies, Charité, University Medicine Berlin, Campus Virchow, Berlin, Germany.
    Mesenchymal stromal cell (MSC) application in Coxsackievirus B3 (CVB3)-induced myocarditis reduces myocardial inflammation and fibrosis, exerts prominent extra-cardiac immunomodulation, and improves heart function. Although the abovementioned findings demonstrate the benefit of MSC application, the mechanism of the MSC immunomodulatory effects leading to a final cardioprotective outcome in viral myocarditis remains poorly understood. Monocytes are known to be a trigger of myocardial tissue inflammation. Read More

    Cardiovascular magnetic resonance imaging pattern at the time of diagnosis of treatment naïve patients with connective tissue diseases.
    Int J Cardiol 2017 Feb 1. Epub 2017 Feb 1.
    Onassis Cardiac Surgery Center, Athens, Greece.
    Background-aim: Cardiac involvement at diagnosis of connective tissue disease (CTD) has been described by echocardiography. We hypothesized that cardio-vascular magnetic resonance (CMR) detects occult lesions at CTD diagnosis.

    Patients-methods: CMR was performed early after diagnosis in 78 treatment-naïve CTDs (aged 43±11, 59F/19M) without cardiac involvement [5 Takayasu arteritis (TA), 4 Churg Strauss syndrome (CSS), 5 Wegener granulomatosis (WG), 16 systemic lupus erythematosus (SLE), 12 rheumatoid arthritis (RA), 8 mixed connective tissue diseases (MCTD), 12 ankylosing spondylitis (AS), 3 polymyalgia rheumatica (PMR), 8 systemic sclerosis (SSc) and 5 dermatomyositis (DM)]. Read More

    Effect of QiShenYiQi pill on myocardial collagen metabolism in experimental autoimmune myocarditis rats.
    Biomed Pharmacother 2017 Feb 5;88:894-901. Epub 2017 Feb 5.
    Department of Geriatric Medicine, First Teaching Hospital of Tianjin University of Traditional Chinese Medcine, 314 An Shan Xi Road, Nan Kai District, Tianjin, 300193, China. Electronic address:
    Objective: To observe the effect of QiShenYiQi pill (QSYQ) on myocardial collagen metabolism in experimental autoimmune myocarditis rats, and to explore its mechanism of action.

    Methods: Lewis rats underwent the injection of myocardial myosin mixed with freund's complete adjuvant were randomized into three groups: model, valsartan and QSYQ groups. And we treated rats which were injected phosphate buffered saline (PBS) mixed with freund's complete adjuvant as control group. Read More

    Effect of Histophilus somni on Heart and Brain Microvascular Endothelial Cells.
    Vet Pathol 2017 Jan 1:300985817691581. Epub 2017 Jan 1.
    4 Department of Pathology, University of California, San Diego, CA, USA.
    Histophilus somni is a pathogenic gram-negative bacterium responsible for pneumonia and septicemia in cattle. Sequelae include infectious thrombotic meningoencephalitis (ITME), myocarditis, arthritis, and abortion. These syndromes are associated with widespread vasculitis and thrombosis, implicating a role for endothelium in pathogenesis. Read More

    Transmissible endoplasmic reticulum stress from myocardiocytes to macrophages is pivotal for the pathogenesis of CVB3-induced viral myocarditis.
    Sci Rep 2017 Feb 8;7:42162. Epub 2017 Feb 8.
    Jiangsu Key Laboratory of Infection and Immunity, Institutes of Biology and Medical Sciences, Soochow University, Suzhou, P.R. China.
    Infiltrating macrophages have been proven as a pivotal pathological inflammatory cell subset in coxsackievirus B3 (CVB3) induced viral myocarditis. However, the mechanisms underlying the initiation and promotion of macrophage pro-inflammatory responses are still blur. We previously reported that cardiac ER stress contributed to CVB3-induced myocarditis by augmenting inflammation. Read More

    Metabolites as biomarkers of adverse reactions following vaccination: A pilot study using nuclear magnetic resonance metabolomics.
    Vaccine 2017 Mar 3;35(9):1238-1245. Epub 2017 Feb 3.
    NIH Common Fund Eastern Regional Comprehensive Metabolomics Resource Core, RTI International, 3040 E Cornwallis Road, Research Triangle Park, NC 27709, USA. Electronic address:
    An Adverse Event Following Immunization (AEFI) is an adverse reaction to a vaccination that goes above and beyond the usual side effects associated with vaccinations. One serious AEFI related to the smallpox vaccine is myopericarditis. Metabolomics involves the study of the low molecular weight metabolite profile of cells, tissues, and biological fluids, and provides a functional readout of the phenotype. Read More

    Rapid Change in Mental Status in a Patient with Hypereosinophilia.
    Case Rep Hematol 2017 10;2017:6936709. Epub 2017 Jan 10.
    Division of Hematology/Oncology, Tufts Medical Center, 800 Washington St., Boston, MA 02111, USA.
    We present the case of a 48-year-old female with acute onset altered mental status, who was found to have eosinophilia, elevated troponin, and embolic strokes. Extensive testing for autoimmune, infectious, and coronary artery etiologies was unremarkable. After a cardiac MRI revealed focal myocardial hyperenhancement, the patient underwent an endomyocardial biopsy with findings consistent with eosinophilic myocarditis. Read More

    Echocardiography for patients undergoing extracorporeal cardiopulmonary resuscitation: a primer for intensive care physicians.
    J Intensive Care 2017 2;5:15. Epub 2017 Feb 2.
    0000 0004 1759 700Xgrid.13402.34Department of Emergency Medicine, Sir Run-Run Shaw Hospital, Zhejiang University School of Medicine, No 3, East Qingchun Road, Hangzhou, 310016 Zhejiang Province China.
    Echocardiography is an invaluable tool in the management of patients with extracorporeal cardiopulmonary resuscitation (ECPR) and subsequent extracorporeal membrane oxygenation (ECMO) support and weaning. At the very beginning, echocardiography can identify the etiology of cardiac arrest, such as massive pulmonary embolism and cardiac tamponade. Eliminating these culprits saves life and may avoid the initiation of extracorporeal cardiopulmonary resuscitation. Read More

    [Myocarditis].
    Rev Med Interne 2017 Feb 1. Epub 2017 Feb 1.
    Service de réanimation médicale, groupe hospitalier Pitié-Salpétrière, 47-83, boulevard de l'Hôpital, 75013 Paris, France.
    Acute myocarditis must be considered in patients with recent onset of cardiac failure or arrhythmia. Fulminant myocarditis is a distinct entity characterized by sudden onset of severe congestive heart failure or cardiogenic shock, usually following a flu-like illness, parvovirus B19, human herpesvirus 6, coxsackie virus and adenovirus being the most frequently viruses responsible for the disease. In this setting, early recognition of patients rapidly progressing to refractory cardiac failure and their immediate transfer to a medical-surgical center experienced in mechanical circulatory support is warranted. Read More

    Galectins - a potential target for cardiovascular therapy.
    Curr Vasc Pharmacol 2017 Feb 1. Epub 2017 Feb 1.
    King Fahd Medical Research Center, King Abdulaziz University, Jeddah, Saudi Arabia.
    Cells constantly adapt to external humoral cues like cytokines and hormones, but practically most cellular behavior is under locally guided control via cell-cell interactions. Galectins (Gals) are one of the most prominent members of the group of molecules involved in this intercellular signaling. They are the family of β-galactoside specific lectins and consist of 15 different types, each with a specific function. Read More

    Characterization of Admission Types in Medically Hospitalized Patients Prescribed Clozapine.
    Psychosomatics 2016 Nov 18. Epub 2016 Nov 18.
    Department of Psychiatry and Psychology, Mayo Clinic, Rochester, MN.
    Background: Clozapine is the antipsychotic of choice for treatment-resistant schizophrenia; however, rigorous monitoring is required to prevent or detect adverse drug events that contribute to morbidity and mortality. In addition to the Food and Drug Administration (FDA) boxed safety warnings specific to clozapine (agranulocytosis, hypotension, seizures, and cardiomyopathy/myocarditis), other adverse events such as pneumonia and gastrointestinal hypomotility have been reported in the literature to result in hospitalization.

    Objective: To explore the reasons for medical hospitalization in patients prescribed clozapine, a retrospective chart review was completed. Read More

    Intein-mediated backbone cyclization of VP1 protein enhanced protection of CVB3-induced viral myocarditis.
    Sci Rep 2017 Feb 2;7:41485. Epub 2017 Feb 2.
    Jiangsu Key Laboratory of Infection and Immunity, Institutes of Biology and Medical Sciences, Soochow University, Suzhou, Jiangsu 215123, China.
    CVB3 is a common human pathogen to be highly lethal to newborns and causes viral myocarditis and pancreatitis in adults. However, there is no vaccine available for clinical use. CVB3 capsid protein VP1 is an immunodominant structural protein, containing several B- and T-cell epitopes. Read More

    Cutting edge clinical applications in cardiovascular magnetic resonance.
    World J Radiol 2017 Jan;9(1):1-4
    Carlo N De Cecco, Akos Varga-Szemes, U Joseph Schoepf, Division of Cardiovascular Imaging, Department of Radiology and Radiological Science, Medical University of South Carolina, Charleston, SC 29425, United States.
    Today, the use of cardiovascular magnetic resonance (CMR) is widespread in clinical practice. The increased need to evaluate of subtle myocardial changes, coronary artery anatomy, and hemodynamic assessment has prompted the development of novel CMR techniques including T1 and T2 mapping, non-contrast angiography and four dimensional (4D) flow. T1 mapping is suitable for diagnosing pathologies affecting extracellular volume such as myocarditis, diffuse myocardial fibrosis and amyloidosis, and is a promising diagnostic tool for patients with iron overload and Fabry disease. Read More

    BACTERIAL MICROBIOTA IN HARBOR SEALS (PHOCA VITULINA) FROM THE NORTH SEA OF SCHLESWIG-HOLSTEIN, GERMANY, AROUND THE TIME OF MORBILLIVIRUS AND INFLUENZA EPIDEMICS.
    J Wildl Dis 2017 Jan 31. Epub 2017 Jan 31.
    3   Institut für Hygiene und Infektionskrankheiten der Tiere, Justus-Liebig-Universität Giessen, Frankfurter Straße 85-89, 35392 Gießen, Germany.
    We present microbiologic findings in harbor seal (phoca; Phoca vitulina ) carcasses collected from the North Sea of Schleswig-Holstein, Germany, 1996-2014, and interpret results in relation to potential variations caused by phocine distemper virus and influenza A virus mass mortalities. We conducted microbiologic investigations on 2,124 tissue samples from lung, liver, kidney, spleen, intestine, and mesenteric lymph nodes from 549 dead harbor seals of the German North Sea. A large variety of bacteria, including potentially pathogenic species such as Bordetella bronchiseptica , Brucella spp. Read More

    [The benefit of magnetic resonance for diagnosing cardiomyopathy and myocarditis].
    Vnitr Lek 2016 ;62(12):976-984
    Magnetic resonance is becoming an increasingly used examination in cardiology, since it greatly improves the accuracy of diagnosing of many heart diseases. At present magnetic resonance is the gold standard in assessing the volumes of the heart chambers and the systolic function of both ventricles. The possibility of detecting tissue characteristics to refine the diagnostics of different types of myocardial pathology is of essential importance. Read More

    Incorporation of a bi-functional protein FimH enhances the immunoprotection of chitosan-pVP1 vaccine against coxsackievirus B3-induced myocarditis.
    Antiviral Res 2017 Apr 28;140:121-132. Epub 2017 Jan 28.
    Jiangsu Key Laboratory of Infection and Immunity, Institutes of Biology and Medical Sciences, Soochow University, Suzhou 215123, PR China. Electronic address:
    Viral myocarditis is a common clinical cardiovascular disease mainly induced by coxsackievirus B3 (CVB3) with no effective therapeutic measures. Induction of efficient mucosal immune responses is very critical against CVB3-induced myocarditis. FimH is an Escherichia coli (E. Read More

    Nonsteroidal anti-inflammatory is more effective than anti-oxidant therapy in counteracting oxidative/nitrosative stress and heart disease in T. cruzi-infected mice.
    Parasitology 2017 Jan 30:1-13. Epub 2017 Jan 30.
    Department of Animal Biology,Federal University of Viçosa,MG 36570-000,Brazil.
    We compared the relevance of ibuprofen, vitamins C and E to control oxidative/nitrosative stress and heart disease in mice infected by Trypanosoma cruzi. Swiss mice were randomized into five groups: control, uninfected; infected without treatment; and infected treated with vitamins C, E or ibuprofen. Animals were inoculated with 2000 trypomastigote forms of T. Read More

    Inhibition of Drp1 attenuates mitochondrial damage and myocardial injury in Coxsackievirus B3 induced myocarditis.
    Biochem Biophys Res Commun 2017 Mar 25;484(3):550-556. Epub 2017 Jan 25.
    Department of Cardiology, The Second Affiliated Hospital, Xi'an Jiaotong University School of Medicine, Xi'an, Shaanxi 710004, China. Electronic address:
    Viral myocarditis (VMC) is closely related to apoptosis, oxidative stress, innate immunity, and energy metabolism, which are all linked to mitochondrial dysfunction. A close nexus between mitochondrial dynamics and cardiovascular disease with mitochondrial dysfunction has been deeply researched, but there is still no relevant report in viral myocarditis. In this study, we aimed to explore the role of Dynamin-related protein 1 (Drp1)-linked mitochondrial fission in VMC. Read More

    Clinical applications of multi-parametric CMR in myocarditis and systemic inflammatory diseases.
    Int J Cardiovasc Imaging 2017 Jan 27. Epub 2017 Jan 27.
    North West Heart Centre, University Hospital of South Manchester, Manchester, UK.
    Cardiac magnetic resonance (CMR) has changed the management of suspected viral myocarditis by providing a 'positive' diagnostic test and has lead to new insights into myocardial involvement in systemic inflammatory conditions. In this review we analyse the use of CMR tissue characterisation techniques across the available studies including T2 weighted imaging, early gadolinium enhancement, late gadolinium enhancement, Lake Louise Criteria, T2 mapping, T1 mapping and extracellular volume assessment. We also discuss the use of multiparametric CMR in acute cardiac transplant rejection and a variety of inflammatory conditions such as sarcoidosis, systemic lupus erythrematous, rheumatoid arthritis and systemic sclerosis. Read More

    Radiologic-Pathologic Correlation of Primary and Secondary Cardiomyopathies: MR Imaging and Histopathologic Findings in Hearts from Autopsy and Transplantation.
    Radiographics 2017 Jan 27:160082. Epub 2017 Jan 27.
    From the Departments of Radiology (H.H., Y.M., M.H., H.N.) and Pathology (H.H., H.I.U.), National Cerebral and Cardiovascular Center, 5-7-1 Fujishiro-dai, Suita, Osaka, Japan; Departments of Diagnostic Radiology (F.K.), Cardiology (S.N.), and Cardiovascular Surgery (A.I.), Saitama Medical University International Medical Center, Hidaka, Japan; Department of Radiology, Tenri Hospital, Tenri, Japan (K.U.); and Department of Radiology, Kobe University, Kobe, Japan (K.S.).
    Cardiac magnetic resonance (MR) imaging with late gadolinium enhancement (LGE) is used to detect and assess the myocardial damage seen with a variety of cardiomyopathies. Gadolinium-based contrast material accumulates in the expanded interstitial space of the myocardium. Areas with LGE correspond to replacement fibrosis, fibrofatty change, epithelioid granuloma, inflammatory cell infiltration, cardiomyocyte necrosis, and amyloid deposition-conditions that represent a focal increase in interstitial space. Read More

    Effects of the MAPK pathway and the expression of CAR in a murine model of viral myocarditis.
    Exp Ther Med 2017 Jan 18;13(1):230-234. Epub 2016 Nov 18.
    Department of Cardiology, Xuzhou Children's Hospital, Xuzhou, Jiangsu 221002, P.R. China.
    The pathogenesis of viral myocarditis (VMC) is not fully understood. This study aimed to examine the relationship between coxsackie-adenovirus receptor (CAR) and the p38 mitogen activated protein kinase (MAPK) pathway mechanisms in a mouse model. Three groups of mice were established: 5 mice in a control group injected with saline, 15 in the model group injected with coxsackie virus B3 (CVB) and 15 in the intervention group injected with CVB3 but treated with the p38 MAPK inhibitor SB203580. Read More

    5-Aminosalicylic Acid-Associated Myocarditis and Pericarditis: A Narrative Review.
    Can J Hosp Pharm 2016 Nov-Dec;69(6):466-472. Epub 2016 Dec 23.
    , PharmD, FCSHP, BCPS(AQ), BCCCP, is with the Pharmacy, St Paul's Hospital, Vancouver, British Columbia. He is also an Associate Editor with the Canadian Journal of Hospital Pharmacy.
    Background: Use of medications containing the 5-aminosalicylic acid (5-ASA) moiety may cause a rare but potentially lethal side effect involving inflammation of the heart (myocarditis) or pericardium (pericarditis) or both (myopericarditis). Early recognition of 5-ASA as the cause is important to prevent progression of the inflammation.

    Objective: To provide clinicians with information to assist in recognizing the signs and symptoms of 5-ASA-induced cardiac inflammation and the characteristics of the suspected therapy, and in determining the appropriate approach to treatment. Read More

    Demographic, clinical and pathological features of sudden deaths due to myocarditis: Results from a state-wide population-based autopsy study.
    Forensic Sci Int 2017 Mar 3;272:81-86. Epub 2017 Jan 3.
    Department of Forensic Medicine, School of Basic Medical Sciences, Fudan University, Shanghai 200032, PR China; Department of Pathology, University of Maryland School of Medicine, 21201, USA; Sino-US Forensic Science Research Center, Collaborative Innovation Center of Judicial Civilization, Office of the Chief Medical Examiner, Baltimore, MD 21223, USA. Electronic address:
    Causes of sudden cardiac deaths have been widely reported with limited data focused specifically on myocarditis. A retrospective review of cases from the Office of the Chief Medical Examiner (OCME), State of Maryland yielded a total of 103 sudden unexpected deaths (SUDs) due to myocarditis (0.17% of all SUDs and 0. Read More

    From Childhood to Adulthood: The Trajectory of Damage in Patients with Childhood-Onset Systemic Lupus Erythematosus.
    Arthritis Care Res (Hoboken) 2017 Jan 24. Epub 2017 Jan 24.
    Objectives 1) To determine the longitudinal damage trajectory of patients with childhood-onset SLE (cSLE). 2) To identify baseline and disease course predictors of damage trajectory. Methods This is a retrospective inception cohort. Read More

    Meningoencephalitis caused by pathogenic Sarcocystis species in a naturally infected sheep in Turkey.
    Tierarztl Prax Ausg G Grosstiere Nutztiere 2017 Feb 24;45(1):42-46. Epub 2017 Jan 24.
    Aylin A. Alasonyalilar-Demirer, Department of Pathology, Faculty of Veterinary Medicine, Uludag University, Gorukle Campus, 16059 Bursa, Turkey, Email:
    A 3-year-old sheep was examined after an acute onset of hind limb paralysis and ataxia. At necropsy, central nervous system, pulmonary and intestinal hyperaemia and ecchymoses in the aortic arch were observed. Main microscopic lesions were confined to the heart, cerebrum and cerebellum. Read More

    Oxymatrine provides protection against Coxsackievirus B3-induced myocarditis in BALB/c mice.
    Antiviral Res 2017 Jan 20. Epub 2017 Jan 20.
    Key Laboratory of Optimal Utilization of Natural Medicinal Resources, Guizhou Medical University, Guiyang 550004, China. Electronic address:
    Oxymatrine is the primary pharmacological component of Sophora flavescens Ait. In the present study, we investigated the protective effect of oxymatrine against Coxsackievirus B3-induced myocarditis in mice. Coxsackievirus B3-infected HeLa cells were treated with oxymatrine and the viral titer, as well as the degree of cellular proliferation were determined. Read More

    High performance personality heartbeat classification model for long-term ECG signal.
    IEEE Trans Biomed Eng 2016 Mar 8. Epub 2016 Mar 8.
    Long-term ECG has become one of the important diagnostic assist methods in clinical cardiovascular domain. Long-term ECG is primarily used for the detection of various cardiovascular diseases that are caused by various cardiac arrhythmia such as myocardial infarction, cardiomyopathy, and myocarditis. In the past few years, the development of an automatic heartbeat classification method has been a challenge. Read More

    Expansion of CD11b(+)Ly-6C(+) myeloid-derived suppressor cells (MDSCs) driven by galectin-9 attenuates CVB3-induced myocarditis.
    Mol Immunol 2017 Mar 19;83:62-71. Epub 2017 Jan 19.
    Central Laboratory of Yijishan Hospital, Wannan Medical College, Wuhu 241001 People's Republic of China. Electronic address:
    Galectin-9 is known to play a role in the modulation of innate and adaptive immunity to ameliorate CVB3-induced myocarditis. In the present study, we found that galectin-9 induced the expansion of CD11b(+)Ly-6C(+) myeloid-derived suppressor cells (MDSCs) in the heart from CVB3-infected mice. Adoptive transfer of CD11b(+)Ly-6C(+) MDSCs significantly alleviated myocarditis accompanied by increased Th2 and Treg frequency and anti-inflammatory cytokines expression in the heart tissue. Read More

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