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Eur J Heart Fail 2020 May 25. Epub 2020 May 25.

Cardiovascular Department, Centre for Diagnosis and Management of Cardiomyopathies, Azienda Sanitaria Universitaria Integrata di Trieste (ASUITS), University of Trieste, Italy.

Background: Contemporary survival trends of Dilated Cardiomyopathy (DCM) patients are largely unknown. The aims of this study are to describe clinical descriptors, survival trends and the prognostic impact of etiological characterization in DCM patients.

Methods: DCM patients were consecutively enrolled and divided into 4 groups according to the period of enrolment: 1 : 1978-1984; 2 : 1985-1994; 3 : 1995-2004; 4 : 2005-2015. Read More

J Leukoc Biol 2020 May 25. Epub 2020 May 25.

Centro de Investigaciones en Bioquímica Clínica e Inmunología (CIBICI), Consejo Nacional de Investigaciones Científicas y Tecnológicas (CONICET), Córdoba, Argentina.

Chronic Chagas cardiomyopathy is the main infectious myocarditis worldwide. Almost 30% of Trypanosoma cruzi infected individuals develop slow and progressive myocarditis that leads to ventricular dilation and heart failure. Heart transplantation is an established, valuable therapeutic option for end-stage Chagas disease patients. Read More

Cardiology 2020 May 25:1-6. Epub 2020 May 25.

Division of Cardiology, Department of Internal Medicine, Brooklyn Campus, Veterans Affairs New York Harbor Healthcare System, Brooklyn, New York, USA,

Various cardiovascular complications have been reported in patients with coronavirus disease 2019. Common complications include acute myocardial injury, myocarditis, arrhythmia, pericarditis, heart failure, and shock. We present a case of cor pulmonale diagnosed with serial point of care ultrasound. Read More

Am J Med Genet A 2020 May 25. Epub 2020 May 25.

Department of Pediatrics, Graduate School of Medicine, Chiba University, Chiba, Japan.

Pathogenic germline variants in the gap junction protein alpha 1 (GJA1) gene have been identified in several congenital disorders affecting cutaneous, skeletal, and cardiac tissues. Here, we describe a 12-year-old patient with a GJA1 c.113G>A, p. Read More

Infection 2020 May 24. Epub 2020 May 24.

Second Department of Medicine, University of Toyama, 2630 Sugitani, Toyama, Toyama, 930-0194, Japan.

Eur J Pediatr 2020 May 23. Epub 2020 May 23.

Department of Pediatric Critical Care, Cleveland Clinic Children's, 9500 Euclid Ave. M14, Cleveland, OH, 44195, USA.

Children affected with acute myocarditis may progress rapidly into profound ventricular dysfunction and ventricular arrhythmias. The objective of this study is to assess the impact of ventricular arrhythmias on in-hospital mortality and the use of mechanical circulatory support in patients with myocarditis. Pediatric patients (age 0-18 years) admitted with myocarditis were identified from the National Inpatient Sample dataset for the years 2002-2015. Read More

Heart 2020 May 23. Epub 2020 May 23.

Heart and Vascular Center, Semmelweis University, Budapest, Hungary.

Objective: We assessed the diagnostic and prognostic implications of early cardiac magnetic resonance (CMR), CMR-based deformation imaging and conventional risk factors in patients with troponin-positive acute chest pain and non-obstructed coronary arteries.

Methods: In total, 255 patients presenting between 2009 and 2019 with troponin-positive acute chest pain and non-obstructed coronary arteries who underwent CMR in ≤7 days were followed for a clinical endpoint of all-cause mortality. Cine movies, T2-weighted and late gadolinium-enhanced images were evaluated to establish a diagnosis of the underlying heart disease. Read More

Med Clin (Barc) 2020 May 19. Epub 2020 May 19.

Servicio de Oncología, Hospital Universitario Nuestra Señora de Candelaria, Santa Cruz de Tenerife, Tenerife, España.

Histopathology 2020 May 22. Epub 2020 May 22.

BIAS - Brazilian Image Autopsy Study Group, Departamento de Patologia, Faculdade de Medicina da Universidade de São Paulo, São Paulo, Brasil.

Aims: Brazil ranks high in the number of COVID-19 cases and COVID-19's mortality rate. In this context, autopsies are important to confirm the disease, determine associated conditions, and study the pathophysiology of this novel disease. In order to follow biosafety recommendations, we used Ultrasound-Guided Minimally Invasive Autopsy (MIA-US) to assess the systemic involvement of COVID-19 and present the results of ten initial autopsies. Read More

Hematol Oncol Stem Cell Ther 2020 May 15. Epub 2020 May 15.

Department of Medical Oncology, Hospital Clínico San Carlos, Madrid, Spain.

As immunotherapy agents are incorporated into the routine oncological practice, the number of patients at the risk of immune-related adverse events has increased dramatically. However, the prompt identification and effective management of severe autoimmune complications remain a challenge. We report the case of a patient with metastatic lung adenocarcinoma who experienced a fatal autoimmune storm 3 weeks after the first dose of anti-programmed death receptor-1 (PD-1) agent pembrolizumab, which included thyroiditis, hepatitis, myositis, myocarditis, pneumonitis, and myasthenia gravis. Read More

J Am Heart Assoc 2020 May 22:e017224. Epub 2020 May 22.

Chair elect of the ACC Adult Congenital and Pediatric Cardiology Section; Congenital Heart Center University of Florida Gainesville FL.

The corona virus disease -2019 (COVID-19) is a recently described infectious disease caused by the severe acute respiratory syndrome corona virus 2 with significant cardiovascular implications. Given the increased risk for severe COVID-19 observed in adults with underlying cardiac involvement, there is concern that patients with pediatric and congenital heart disease (CHD) may likewise be at increased risk for severe infection. The cardiac manifestations of COVID-19 include myocarditis, arrhythmia and myocardial infarction. Read More

J Cardiovasc Transl Res 2020 May 21. Epub 2020 May 21.

Berlin Institute of Health Center for Regenerative Therapies (BCRT), Charité - Universitätsmedizin Berlin, Campus Virchow Klinikum (CVK), Föhrerstrasse 15, 13353, Berlin, Germany.

Myocarditis is a multifactorial disorder, characterized by an inflammatory reaction in the myocardium, predominantly triggered by infectious agents, but also by antigen mimicry or autoimmunity in susceptible individuals. Unless spontaneously resolved, a chronic inflammatory course concludes with cardiac muscle dysfunction portrayed by ventricular dilatation, clinically termed inflammatory cardiomyopathy (Infl-CM). Treatment strategies aim to resolve chronic inflammation and preserve cardiac function. Read More

J Heart Lung Transplant 2020 Apr 18. Epub 2020 Apr 18.

Departments of Cardiovascular Surgery, Kyushu University, Fukuoka, Japan.

JACC Clin Electrophysiol 2020 May;6(5):583-585

Cardiac Electrophysiology, Cardiovascular Medicine Division, Hospital of the University of Pennsylvania, Philadelphia, Pennsylvania.

JACC Clin Electrophysiol 2020 May 26;6(5):574-582. Epub 2020 Feb 26.

Department of Cardiovascular and Thoracic Sciences, Fondazione Policlinico Universitario A. Gemelli IRCCS, Rome, Italy; Institute of Cardiology, Università Cattolica del Sacro Cuore, Rome, Italy.

Objectives: This study sought to assess long-term arrhythmic risk in patients with myocarditis who received an implantable cardioverter-defibrillator (ICD).

Background: The arrhythmic risk of patients with myocarditis overtime remains poorly known.

Methods: The study enrolled 56 patients with biopsy-proven myocarditis who received an ICD for either primary (57%) or secondary prevention (43%) according to current guidelines. Read More

Adv Ther 2020 May 20. Epub 2020 May 20.

S.C. Cardiologia, Istituto Nazionale Tumori, IRCCS Fondazione G. Pascale, Napoli, Italy.

Introduction: Cardiovascular toxicity of immunotherapy represents an underreported but potentially fatal side effect. A relatively high incidence of pericardial disease has been noticed in patients with non-small cell lung cancer (NSCLC).

Methods: We retrospectively analyzed a population of patients with advanced NSCLC receiving immune checkpoint inhibitors (ICIs) looking for the presence of pericardial effusion at baseline or during treatment. Read More

Front Pharmacol 2020 6;11:600. Epub 2020 May 6.

Department of Traditional Chinese Medicine, Liaocheng People's Hospital, Liaocheng, China.

Xin Su Ning (XSN), a China patented and certified multi-herbal medicine, has been available in China since 2005 for treating cardiac ventricular arrhythmia including arrhythmia induced by ischemic heart diseases and viral myocarditis, without adverse reactions being reported. It is vitally important to discover pharmacologically how XSN as a multicomponent medicine exerts its clinical efficacy, and whether the therapeutic effect of XSN can be verified by standard clinical trial studies. In this paper we report our discoveries in a cellular electrophysiological study and in a three-armed, randomized, double-blind, placebo-controlled, parallel-group, multicenter trial. Read More

Egypt J Neurol Psychiatr Neurosurg 2020 29;56(1):15. Epub 2020 Jan 29.

National Hospital of Sri Lanka, Colombo, Sri Lanka.

Introduction: Systemic lupus erythematosus is a connective tissue disorder, which causes complex multi organ involvement. Neurological and cardiac manifestations have been well noted but complications such as status epilepticus and acute myocarditis with heart failure at presentation remains uncommon.

Case Description: A 15-year-old, previously healthy, South Asian, Sri Lankan female presented with status epilepticus and the seizures only responded to intravenous midazolam and thiopentone sodium. Read More

Cleve Clin J Med 2020 May 20. Epub 2020 May 20.

Department of Nephrology and Hypertension, Glickman Urological and Kidney Institute, Cleveland Clinic.

Acute kidney injury has been reported in as many as 29% of COVID-19 patients. Reported risk factors include elevated baseline serum creatinine, elevated blood urea nitrogen, acute kidney injury, proteinuria, and hematuria. Suspected causes include sepsis and acute tubular necrosis resulting from renal hypoperfusion, cytokine release syndrome, direct viral invasion, renal medullary hypoxia secondary to alveolar damage, rhabdomyolysis, and cardiorenal syndrome due to viral myocarditis. Read More

J Immunother Cancer 2020 05;8(1)

Department of Medicine, Massachusetts General Hospital Cancer Center, Boston, Massachusetts, USA.

COVID-19 infections are characterized by inflammation of the lungs and other organs that ranges from mild and asymptomatic to fulminant and fatal. Patients who are immunocompromised and those with cardiopulmonary comorbidities appear to be particularly afflicted by this illness. During pandemic conditions, many aspects of cancer care have been impacted. Read More

Cardiovasc Pathol 2020 May 7;48:107233. Epub 2020 May 7.

Internal Medicine, McGovern Medical School, The University of Texas Health Science Center at Houston (UTHealth), Houston, Texas, USA; Center for Advanced Cardiopulmonary Therapies and Transplantation, McGovern Medical School and Memorial Hermann Hospital-Texas Medical Center, Houston, Texas, USA.

This paper collates the pathological findings from initial published autopsy reports on 23 patients with coronavirus disease 2019 (COVID-19) from 5 centers in the United States of America, including 3 cases from Houston, Texas. Findings confirm that COVID-19 is a systemic disease with major involvement of the lungs and heart. Acute COVID-19 pneumonia has features of a distinctive acute interstitial pneumonia with a diffuse alveolar damage component, coupled with microvascular involvement with intra- and extravascular fibrin deposition and intravascular trapping of neutrophils, and, frequently, with formation of microthombi in arterioles. Read More

J Chin Med Assoc 2020 May 18. Epub 2020 May 18.

Division of Cardiology, Department of Medicine, Taipei Veterans General Hospital, Taipei, Taiwan, ROC.

The novel coronavirus disease 2019 (COVID-19), with first presentation of atypical pneumonia, has spread rapidly from Wuhan, China on December 12, 2019 to over 200 countries, caused 2310572 infected individuals and 158691 mortalities, updated on 2020/4/19. Many studies have published timely to help global health-care workers to understand and control the disease. Vulnerable patients with risk factors such as elderly, cardiovascular diseases (e. Read More

Pediatr Infect Dis J 2020 May 19. Epub 2020 May 19.

Department of Pediatrics, ASST-FBF-Sacco, Vittore Buzzi Children's Hospital, University of Milan, Milan, Italy.

Severe acute respiratory syndrome coronavirus 2 infection in children mainly shows a milder course. In complicated cases, it is unknown whether inflammation is predictive of disease severity, as in adults. Moreover, cardiac involvement is anecdotally described. Read More

Am J Med Case Rep 2020 22;8(7):192-196. Epub 2020 Apr 22.

Department of Internal Medicine, SUNY-Downstate- Health Science University, Brooklyn, New York, U.S.A.- 11203.

Coronavirus disease 2019 (COVID-19) is a pandemic that started in the Wuhan province of China in December 2019. It is associated with increased morbidity and mortality mainly due to severe acute respiratory syndrome 2 (SARS-Cov-2). Cardiac manifestations related to COVID-19 include demand ischemia, fulminant myocarditis, myocardial infarction and arrhythmias. Read More

Front Pediatr 2020 5;8:186. Epub 2020 May 5.

Department of Pediatrics, Anhui Provincial Hospital, Wannan Medical College, Hefei, China.

To investigate the clinical features, treatment methods, and outcomes of fulminant myocarditis (FM) in children. The clinical data of 23 children with FM hospitalized in the First Affiliated Hospital of USTC, Division of Life Sciences and Medicine, University of Science and Technology of China (Anhui Provincial Hospital) and Anhui Provincial Children's Hospital from January 2011 to September 2019 were retrospectively analyzed. Among the 23 patients analyzed, 10 were male and 13 were female. Read More

Circulation 2020 May 20. Epub 2020 May 20.

State Key Laboratory of Cardiovascular Disease, Fuwai Hospital, National Center for Cardiovascular Diseases, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing, China.

Myocarditis can develop into dilated cardiomyopathy (DCM), which may require heart transplantation (HTx). The immunological network of myocarditis phases remains unknown. This study aimed to investigate the immunological network during the transition from myocarditis to cardiomyopathy and to identify the genes contributing to the inflammatory response to myocarditis. Read More

Eur J Heart Fail 2020 May 19. Epub 2020 May 19.

Berlin Institute of Health Center for Regenerative Therapies (BCRT), Charité, University Medicine Berlin, Campus Virchow Clinic, Berlin, Germany.

Pediatr Infect Dis J 2020 May 11. Epub 2020 May 11.

From the Centre Hospitalier du Luxembourg, Luxembourg, Grand-Duché du Luxembourg.

We report the case of a pediatric life-threatening coronavirus disease 2019 who presented as myocarditis with heart failure. Clinicians should be aware of this severe presentation of the disease in children, possibly linked to an exaggerated inflammatory host immune response to severe acute respiratory syndrome coronavirus 2. Read More

Ann Oncol 2020 May 16. Epub 2020 May 16.

Centre Hospitalier Universitaire Vaudois (CHUV), Department of Medicine, Immunology and Allergy Division, Rue du Bugnon 46, CH-1011 Lausanne, Switzerland.

Can J Cardiol 2020 May 16. Epub 2020 May 16.

The Zena and Michael A. Wiener Cardiovascular Institute, Icahn School of Medicine at Mount Sinai, New York, NY, USA.

The Coronavirus disease 2019 (COVID-19), caused by severe acute respiratory syndrome coronavirus-2 (SARS-CoV-2), represents the pandemic of the century, with approximately 3.5 million cases and 250,000 deaths worldwide as of May 2020. Although respiratory symptoms usually dominate the clinical presentation, COVID-19 is now known to also have potentially serious cardiovascular consequences, including myocardial injury, myocarditis, acute coronary syndromes, pulmonary embolism, stroke, arrhythmias, heart failure, and cardiogenic shock. Read More

G Ital Cardiol (Rome) 2020 Jun;21(6):417-420

U.O. Cardiologia, Ospedale Guglielmo da Saliceto, Piacenza.

Takotsubo syndrome (TTS) is one of the causes of myocardial infarction with non-obstructive coronary arteries, and is often triggered by physical events (e.g. acute respiratory failure), or emotional events (e. Read More

J Cell Mol Med 2020 May 18. Epub 2020 May 18.

Institute of Cardiovascular Development and Translational Medicine, The Second Affiliated Hospital and Yuying Children's Hospital of Wenzhou Medical University, Wenzhou, China.

Human umbilical cord mesenchymal stem cell-derived exosomes (hucMSC-exosomes) have been implicated as a novel therapeutic approach for tissue injury repair and regeneration, but the effects of hucMSC-exosomes on coxsackievirus B3 (CVB3)-induced myocarditis remain unknown. The object of the present study is to investigate whether hucMSC-exosomes have therapeutic effects on CVB3-induced myocarditis (VMC). HucMSC-exosomes were identified using nanoparticle tracking analysis (NTA), transmission electron microscopy (TEM) and Western blot. Read More

Cardiovasc Revasc Med 2020 May 15. Epub 2020 May 15.

Section of Interventional Cardiology, MedStar Washington Hospital Center, Washington, DC, United States of America. Electronic address:

Coronavirus disease 2019 (COVID-19) is an infectious disease caused by severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2). Cardiovascular manifestations of COVID-19 are diverse and complex and include acute coronary syndrome, myocarditis masquerading as ST-segment elevation myocardial infarction, pericarditis and pericardial effusion. We present 2 cases of COVID-19 infection with myocardial involvement with distinct mechanistic pathways and outcomes. Read More

Arch Pathol Lab Med 2020 May 18. Epub 2020 May 18.

From the Department of Pathology and Laboratory Medicine, Long School of Medicine (Drs Yan and Gilbert); the Department of Internal Medicine, Long School of Medicine (Dr Mir); the Division of Pulmonary Disease and Critical Care Medicine, Long School of Medicine (Drs Sanchez, Beg, Peters and Enriquez), University of Texas Health San Antonio, Texas.

Since making its debut on the global stage in December 2019, Coronavirus Disease 2019 (COVID-19) has afflicted nearly four million people and caused hundreds of thousands of deaths. Case reports and case series depicting the clinical effects of the causative virus, Severe Acute Respiratory Syndrome Coronavirus 2 (SARS-CoV-2) have been published, yet few demonstrate the cytopathologic alterations of this disease. We present a clinical-pathological correlation report of a previously healthy Hispanic woman with laboratory-confirmed COVID-19 who had typical features of acute respiratory distress syndrome (ARDS), and also showed cardiac abnormalities thought to represent fulminant viral myocarditis. Read More

Cardiovasc Diagn Ther 2020 Apr;10(2):242-243

Department of Radiology, The Second Affiliated Hospital of Kunming Medical University, Kunming 650101, China.

Transl Lung Cancer Res 2020 Apr;9(2):360-365

Department of Medical Oncology, Olivia Newton-John Cancer and Wellness Centre, Heidelberg, Australia.

Malignant pleural mesothelioma (MPM) remains a deadly disease with limited therapeutic options beyond platinum/pemetrexed chemotherapy. Immune checkpoint inhibitors have demonstrated modest benefit in the second to later-line settings. An MPM patient from our institute developed myocarditis and myositis after 2 cycles of second-line nivolumab. Read More

Eur Cardiol 2020 Feb 30;15:e20. Epub 2020 Apr 30.

University of Hertfordshire Hertfordshire, UK.

MI with non-obstructive coronary artery (MINOCA) is a condition previously thought to be benign that has recently been shown to have comparable mortality to that of acute coronary syndrome with obstructive coronary disease. The heterogeneity of the underlying aetiology makes the assessment, investigation and treatment of patients with MINOCA challenging. The majority of patients with MINOCA presenting with ST-segment elevation MI generally have an underlying coronary or myocardial cause, predominantly plaque disruption or myocarditis. Read More

Heart Lung Circ 2020 May 1. Epub 2020 May 1.

St Vincent's Hospital, Sydney, NSW, Australia; The University of New South Wales, Sydney, NSW, Australia. Electronic address:

Up to one-third of COVID-19 patients admitted to intensive care develop an acute cardiomyopathy, which may represent myocarditis or stress cardiomyopathy. Further, while mortality in older patients with COVID-19 appears related to multi-organ failure complicating acute respiratory distress syndrome (ARDS), the cause of death in younger patients may be related to acute heart failure. Cardiac involvement needs to be considered early on in critically ill COVID-19 patients, and even after the acute respiratory phase is passing. Read More

J Cardiovasc Magn Reson 2020 May 18;22(1):35. Epub 2020 May 18.

Department of Cardiology I, Division of Cardiovascular Imaging, University Hospital Münster, Münster, Germany.

Background: Cardiovascular magnetic resonance (CMR) studies in patients with implanted cardioverter/defibrillators (ICD) are increasingly required in daily clinical practice. However, the clinical experience regarding the feasibility as well as clinical value of CMR studies in patients with subcutaneous ICD (S-ICD) is still limited. Besides safety issues, image quality and analysis can be impaired primarily due the presence of image artefacts associated with the generator. Read More

Circulation 2020 May 17. Epub 2020 May 17.

M3C-Necker Enfants Malades, AP-HP, Paris, France; Université de Paris, Paris, France.

Cardiac injury and myocarditis have been described in adults with COVID-19. SARS-CoV-2 infection in children is typically minimally symptomatic. We report a series of febrile pediatric patients with acute heart failure potentially associated with SARS-CoV-2 infection and the multisystem inflammatory syndrome in children (MIS-C) as defined by the US Centers for Disease Control. Read More

Can J Cardiol 2020 May 13. Epub 2020 May 13.

- Radiology Department, Fattouma Bourguiba University Hospital and University of Monastir, Monastir, Tunisia.

Acute myocarditis is extremely rare in Behcet's disease (BD). Here we report a case of a 32-year-old man with a history of oral ulcerations who was admitted for fever and chest pain. On examination, he had bipolar ulcers with pseudofolliculitis and a positive pathergy test. Read More

Pharmacol Res 2020 May 13:104907. Epub 2020 May 13.

Institute of Biomedical Sciences, Federal University of Alfenas, Alfenas, 37130-001, Minas Gerais, Brazil; Department of Structural Biology, Federal University of Alfenas, Alfenas, 37130-001, Minas Gerais, Brazil. Electronic address:

Phenothiazines inhibit major antioxidant defense mechanisms in trypanosomatids and exhibit potent cytotoxic effects in vitro. However, the relevance of these drugs in the treatment of Trypanosoma cruzi-induced acute myocarditis is poorly explored, especially in combination with reference trypanocidal drugs. Thus, we compared the antiparasitic and cardioprotective potential of thioridazine (TDZ) and benznidazole (Bz) administered in monotherapy and combined in a murine model of T. Read More

Lancet Oncol 2020 May 13. Epub 2020 May 13.

Jiangsu Hengrui Medicine, Shanghai, China.

Background: Patients with advanced or metastatic oesophageal squamous cell carcinoma have poor prognosis and few treatment options after first-line therapy. We aimed to assess efficacy and safety of the anti-PD-1 antibody camrelizumab versus investigator's choice of chemotherapy in previously treated patients.

Methods: ESCORT is a randomised, open-label, phase 3 study of patients aged 18 to 75 years with a histological or cytological diagnosis of advanced or metastatic oesophageal squamous cell carcinoma done at 43 hospitals in China. Read More

FEBS Open Bio 2020 May 16. Epub 2020 May 16.

Department of Cardiology, Zhejiang Provincial People's Hospital, People's Hospital of Hangzhou Medical College, No.158 Shangtang Road, Hangzhou, 310014, Zhejiang, P R China.

Myocarditis is an inflammatory disease of the myocardium associated with immune dysfunction. Earlier studies have suggested that Th1/Th2 cell imbalance plays an important role in the development of myocarditis, but the role of Tfh cells in the development of autoimmune myocarditis has not previously been reported. Here, we investigated this involvement by using a rat model of experimental autoimmune myocarditis (EAM). Read More

Am J Case Rep 2020 May 16;21:e923684. Epub 2020 May 16.

Department of Cardiovascular Surgery, Mackay Memorial Hospital, Taipei, Taiwan.

BACKGROUND Venom related fulminant myocarditis is uncommon. The clinical course varies, and histopathology is usually unclear, however, refractory cardiogenic shock is rare. CASE REPORT We reported a case of a 36-year-old female who developed fever and cardiogenic shock 3 days after a bee sting. Read More

Can J Cardiol 2020 May 12. Epub 2020 May 12.

Department of Cardiovascular, Renal and Metabolic Medicine.

A 14-year-old girl with cardiopulmonary arrest was referred to our hospital. She had received an injection of inactivated influenza vaccine 7 days before the referral. Her cardiac rhythm was pulseless wide QRS tachycardia, and mechanical circulatory support was immediately commenced. Read More

Altern Ther Health Med 2020 May 15. Epub 2020 May 15.

By April 28th 2020, the global number of people that were viciously infected with the newfound novel corona virus (COVID-19) stood at a staggering 3 077 133 cases, as per the confirmed data released by the WHO. It has been reported that women from the Chinese Han population are associated with essential hypertension due to their relation with the 5 SNPs, namely, rs1514283, rs4646155, rs4646176, rs2285666, and rs879922, which belong to the ACE2 gene. The level of ACE2 activity was very low in normal healthy younger persons, and was reported to be increased in patients with cardiovascular diseases. Read More

Pol J Microbiol 2020 ;69:1-8

Department of Pharmacy, Abasyn University , Peshawar KP , Pakistan.

Measles infection is of substantial interest to immunologists due to its paradoxical interaction with the immune system. After the acquisition of the measles infection, secondary infection plays a pivotal role in measles-related deaths. A cross-sectional study conducted between December 2018 and July 2019 is presented here. Read More

Eur J Heart Fail 2020 May 15. Epub 2020 May 15.

Institute of Cardiology, ASST Spedali Civili di Brescia and Department of Medical and Surgical Specialities, Radiological Sciences and Public Health, University of Brescia, Brescia, Italy.

Patients with cardiovascular disease and, namely, heart failure are more susceptible to coronavirus disease 2019 (COVID-19) and have a more severe clinical course once infected. Heart failure and myocardial damage, shown by increased troponin plasma levels, occur in at least 10% of patients hospitalized for COVID-19 with higher percentages, 25%-35% or more, when patients critically ill or with concomitant cardiac disease are considered. Myocardial injury may be elicited by multiple mechanisms, including those occurring with all severe infections, such as fever, tachycardia, adrenergic stimulation, as well as those caused by the exaggerated inflammatory response, endotheliitis and, in some cases, myocarditis that have been shown in patients with COVID-19. Read More

Cardiol Res Pract 2020 30;2020:5695723. Epub 2020 Jan 30.

Department of Pediatrics, The Third Xiangya Hospital, Central South University, Hunan Province, Changsha 410013, China.

Cardiovascular disease, which can lead to angina and shortness of breath, remains one of the most serious threats to human health. Owing to its imperceptible symptoms, it is difficult to determine the pathogenesis and treatment methods for cardiovascular disease. Nuclear factor erythropoietin-2-related factor 2/heme oxygenase 1 (Nrf2/HO-1) is a protein found in all cells of the human body. Read More