538,588 results match your criteria Myocardial Ischemia - Nuclear Medicine and Risk Stratification


Association of Central Venous Oxygen Saturation Variability and Mortality in Hemodialysis Patients.

Blood Purif 2018 Dec 6:1-8. Epub 2018 Dec 6.

Renal Research Institute, New York, New York,

Background: Central venous oxygen saturation (ScvO2) is correlated with cardiac output. In most patients, ScvO2 declines during hemodialysis (HD) due to factors such as reduced preload, myocardial stunning, and intermittent arrhythmias. Previous research has shown that low ScvO2 is associated with higher mortality in chronic HD patients. Read More

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December 2018

The appropriateness of coronary investigation in myocardial injury and type 2 myocardial infarction (ACT-2): A randomized trial design.

Am Heart J 2018 Oct 25;208:11-20. Epub 2018 Oct 25.

Department of Cardiology, Flinders Medical Centre, Adelaide, Australia; College of Medicine and Public Health, Flinders University of South Australia, Adelaide, Australia. Electronic address:

Background: Elevated troponin level findings among patients presenting with suspected acute coronary syndrome (ACS) or another intercurrent illness undeniably identifies patients at increased risk of mortality. Whilst enhancing our capacity to discriminate risk, the use of high-sensitivity troponin assays frequently identifies patients with myocardial injury (i.e. Read More

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October 2018
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Cardiovascular development and survival require Mef2c function in the myocardial but not the endothelial lineage.

Dev Biol 2018 Dec 3. Epub 2018 Dec 3.

Cardiovascular Research Institute, University of California, San Francisco, San Francisco, CA, 94143, USA; Department of Biochemistry and Biophysics, University of California, San Francisco, San Francisco, CA, 94143, USA. Electronic address:

MEF2C is a member of the highly conserved MEF2 family of transcription factors and is a key regulator of cardiovascular development. In mice, Mef2c is expressed in the developing heart and vasculature, including the endothelium. Loss of Mef2c function in germline knockout mice leads to early embryonic demise and profound developmental abnormalities in the cardiovascular system. Read More

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December 2018

Myocardial Injury in Critically Ill Patients with Community-acquired Pneumonia: A Cohort Study.

Ann Am Thorac Soc 2018 Dec 6. Epub 2018 Dec 6.

University Medical CenterUtrecht, Utrecht, Netherlands.

Rationale: Myocardial injury, as reflected by elevated cardiac troponin levels in plasma, is common in patients with community-acquired pneumonia (CAP), but its temporal dynamics and etiology remain unknown.

Objectives: Our aim was to determine the incidence of troponin release in patients with CAP and identify risk factors which may point to underlying etiologic mechanisms.

Methods: We included consecutive patients admitted with severe CAP to two intensive care units in the Netherlands between 2011 and 2015. Read More

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December 2018
1 Read

[Functional results and complications of the use of the proximal femoral nail in the treatment of intertrochanteric hip fractures].

Acta Ortop Mex 2018 May-Jun;32(3):126-130

Centro de Evaluación de Tecnologías, Universidad CES, Medellín, Colombia.

Introduction: Cephalomedullary nails are used for the treatment of hip fractures; however, there are few studies that allow identifying data on the complications of the use of these devices and the results in terms of restoration of the functionality of the patient.

Methods: A cross-sectional study of patients with femur fracture was conducted during the period from January 2008 to December 2012. Data on demographic and clinical variables were collected. Read More

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December 2018

Gallic Acid Suppresses Cardiac Hypertrophic Remodeling and Heart Failure.

Mol Nutr Food Res 2018 Dec 6:e1800807. Epub 2018 Dec 6.

Dr. X. Yan, Y.-L. Zhang, L. Zhang, L.-X. Zou, C. Chen, Prof. Y. Liu, Prof. Y.-L. Xia, Prof. H.-H. Li, Department of Nutrition and Food Hygiene, School of Public Health, Dalian Medical University, Dalian, 116044, China.

Scope: Gallic acid (GA) is a dietary phenolic acid found in tea, red wine, and some plants. It exhibits antioxidative and anti-inflammatory activities. Recent studies have revealed that GA has beneficial effects against several cardiovascular diseases; however, whether GA attenuates pressure overload-induced cardiac hypertrophy and the underlying mechanism remain unclear. Read More

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December 2018
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Prospective, randomized trial of bioresorbable scaffolds vs. everolimus-eluting stents in patients undergoing coronary stenting for myocardial infarction: the Intracoronary Scaffold Assessment a Randomized evaluation of Absorb in Myocardial Infarction (ISAR-Absorb MI) trial.

Eur Heart J 2018 Dec 5. Epub 2018 Dec 5.

Department of Cardiovascular Diseases, Deutsches Herzzentrum München, Technische Universität München, Lazarettstrasse 36, Munich, Germany.

Aims: Bioresorbable scaffolds (BRS) provide short-term coronary artery scaffolding and drug delivery. Although prior trials showed a higher rate of device failure compared with conventional drug-eluting stents (DES), only a single trial investigated patients undergoing percutaneous coronary intervention (PCI) for acute myocardial infarction (MI). We aimed to compare outcomes with BRS vs. Read More

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December 2018

[Regional network for ST-elevation myocardial infarction in Italy: from development to management].

G Ital Cardiol (Rome) 2018 Dec;19(12):721-723

U.O.C. Cardiologia, Ospedale Maggiore, Bologna.

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December 2018

[The second multicenter observational registry on the management of acute ST-elevation myocardial infarction in the Veneto Region (VENERE 2)].

Authors:

G Ital Cardiol (Rome) 2018 Dec;19(12):714-720

Background: We sought to evaluate the epidemiology and the management of ST-elevation acute myocardial infarction (STEMI) in the Veneto Region (VENERE 2) in 2014, 10 years after a similar survey conducted in the early 2000s.

Methods: Between October 2014 and March 2015, all consecutive patients admitted to the Cardiology Divisions of the Veneto Region with STEMI were enrolled in an observational, prospective, multicenter register, called VENERE 2. The main diagnostic and therapeutic efficiency indicators were analyzed and compared with data from the previous VENERE study performed 10 years earlier. Read More

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December 2018

[Usefulness, timing and modality of ECG stress testing after myocardial revascularization].

G Ital Cardiol (Rome) 2018 Dec;19(12):692-704

Istituto di Cardiologia, Università degli Studi, Pisa.

Myocardial revascularization in patients with stable ischemic heart disease aims at eliminating myocardial ischemia, in order to (i) relieve anginal symptoms; (ii) improve functional capacity; and, possibly, (iii) improve prognosis. Given that ischemic recurrences are relatively common in patients undergoing myocardial revascularization, an appropriate follow-up is needed as part of a secondary prevention program. Stress testing can be here useful to: (i) detect residual or recurrent ischemia/angina; (ii) define functional capacity in order to establish physical aerobic training individualized programs; (iii) stratify prognosis. Read More

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December 2018
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[Clinical applications of cardiac magnetic resonance imaging: heart failure and cardiomyopathies].

G Ital Cardiol (Rome) 2018 Dec;19(12):679-691

Dipartimento Cardiovascolare, ASST Papa Giovanni XXIII, Bergamo.

Cardiac magnetic resonance (CMR) has proved to be a powerful tool in the assessment of several cardiac diseases, thanks to its capability to offer multiparametric morphologic and functional evaluation of the heart and great vessels, using neither ionizing radiations nor nephrotoxic contrast medium. The accuracy in quantification of cardiac volumes and ejection fraction (gold standard) together with native and post-contrast myocardial tissue characterization have made CMR an invaluable tool for the diagnosis, prognosis and therapeutic planning in patients with heart failure and cardiomyopathy. Read More

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December 2018
2 Reads

[Journey around the heart in the movies of the last century: from Charlie Chaplin to the present day].

Authors:
Andrea Pozzati

G Ital Cardiol (Rome) 2018 Dec;19(12):664-667

U.O.S. Cardiologia, Ospedale Dossetti di Bazzano (BO), AUSL di Bologna.

Imagine a journey through the cinema's history to recover the figure of the doctor in the last century. At the same time, we have found that the progress of medicine has conditioned the stories told on the big screen. Cardiology has achieved a leading role at the cinema when technological innovations have begun to emerge, from the '60s onwards. Read More

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December 2018

Transient Q-waves in an infant with asymptomatic myocardial infarction due to Kawasaki disease.

Cardiol Young 2018 Dec 6:1-4. Epub 2018 Dec 6.

Department of Pediatrics,Shinshu University School of Medicine,Asahi 3-1-1, Matsumoto,Japan.

Giant coronary artery aneurysms are a complication of Kawasaki disease and can be fatal if associated with thrombosis. We describe the clinical outcome of a boy with Kawasaki disease who exhibited "supergiant" coronary artery aneurysms at the age of 14 months and, despite treatment with anticoagulant and antiplatelet medication, developed a left coronary artery thrombosis and presented following a myocardial infarction at 2 years old. Although his symptoms were minimal, the myocardial infarction was identified by abnormal Q-waves and giant negative T-waves in precordial leads of routine electrocardiography. Read More

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December 2018

Engineered Heart Slice Model of Arrhythmogenic Cardiomyopathy using Plakophilin-2 Mutant Myocytes.

Tissue Eng Part A 2018 Dec 6. Epub 2018 Dec 6.

Johns Hopkins University School of Medicine, Biomedical Engineering, Baltimore, Maryland, United States ;

Arrhythmogenic cardiomyopathy (AC), a cause of sudden cardiac death among young and otherwise healthy individuals, is a heritable disease that can be modeled in vitro using patient-specific cardiac myocytes (CMs) from induced pluripotent stem cells. An understanding of underlying disease mechanisms, particularly in the early concealed stages, could lead to new diagnosis and treatment strategies. However, multicellular syncytial models are needed to understand how genetically-encoded mutations of the desmosomes that interconnect cells lead to aberrant electrical conduction and arrhythmias. Read More

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December 2018

[The hybrid strategy for complete myocardial revascularization in the frail elderly patient].

G Ital Cardiol (Rome) 2018 Nov;19(11):33-38

U.O.C. Cardiologia, Ospedale Belcolle, Viterbo.

The hybrid strategy allows for a complete myocardial revascularization in patients with multivessel coronary artery disease and a high frailty index. These patients, due to their old age and multi-comorbidities, are evaluated with inadequate tools for their clinical complexity and destined to an incomplete revascularization for increased surgical or procedural risk. Hybrid revascularization enables to use the best techniques resulting from the surgical and percutaneous approach defining a tailored strategy for the patient. Read More

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November 2018
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[Coronary artery disease: when to withhold a decision and call in the Heart Team? Almost never].

G Ital Cardiol (Rome) 2018 Nov;19(11):18-21

Divisione di Cardiologia, Centro Alte Specialità e Trapianti (CAST), Ospedale Policlinico Gaspare Rodolico, Università degli Studi, Catania.

The expansion of the options for the treatment of patients with stable multivessel coronary artery disease (CAD), including medical therapy or myocardial revascularization by a surgical or a percutaneous strategy, has raised the need to set the decision-making process to select the optimal therapy on a multidisciplinary approach. Indeed, this latter would potentially lead to identify the most appropriate strategy for a given patient in the most transparent, shared and comprehensive way as possible. The multidisciplinary approach has been widely encouraged in the cardiovascular field, where it has been defined as "Heart Team" (HT), a collegial system essentially including a cardiac surgeon, a clinical cardiologist and an interventionalist. Read More

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November 2018

[What's new in the 2018 ESC/EACTS guidelines on myocardial revascularization?]

G Ital Cardiol (Rome) 2018 Nov;19(11):5-9

Klinik für Kardiologie und Angiologie II, Universitäts-Herzzentrum Freiburg, Bad Krozingen, Germania.

A revised version of the European Society of Cardiology (ESC) and European Association for Cardio-Thoracic Surgery (EACTS) guidelines on myocardial revascularization has recently been published. These guidelines represent the third time that the ESC and EACTS have brought together cardiologists and cardiac surgeons in a joint Task Force to review the available evidence, with the mission of drafting balanced, patient-oriented, clinical practice guidelines on myocardial revascularization. During the last 4 years, a large body of evidence has become available and brought substantial changes to the guidelines. Read More

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November 2018

Circular RNA expression profiles of persistent atrial fibrillation in patients with rheumatic heart disease.

Anatol J Cardiol 2018 Dec 6. Epub 2018 Dec 6.

Department of Cardiology, Xijing Hospital, Air Force Military Medical University (Fourth Military Medical University); Xi'an-China.

Objective: To investigate the expression profile of circular RNAs (circRNAs) and proposed circRNA-microRNA (miRNA) regulatory network in atrial fibrillation (AF).

Methods: Atrial tissues from patients with persistent AF with rheumatic heart disease and non-AF myocardium with normal hearts were collected for circRNA differential expression analyses by high-throughput sequencing. The Gene Ontology (GO) and Kyoto Encyclopedia of Genes and Genomes (KEGG) pathway enrichment analyses were performed to predict the potential functions of the differentially expressed genes and AF-related pathways. Read More

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December 2018

Diagnostic Value of HLA Typing in Pathogenesis of Cardiomyopathy.

Cardiovasc Hematol Disord Drug Targets 2018 Dec 5. Epub 2018 Dec 5.

Thalassemia and Hemoglobinopathy Research Center, Research Institute of Health, Ahvaz Jundishapur University of Medical Sciences, Ahvaz. Iran.

Development of cardiomyopathy (CM) is dependent upon several factors. However, reaction of immune response against myocardial tissue due to microbial and viral infections plays an important role in this disease. Therefore, the purpose of this study is to investigate the relationship between HLAs and their pathogenic mechanisms in the incidence of CM. Read More

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December 2018

Extensively thrombosed ectatic circumflex coronary artery fistula presenting as acute coronary syndrome.

Curr Cardiol Rev 2018 Dec 6. Epub 2018 Dec 6.

Department of Cardiology, University Heart Center, University Hospital Zurich. Switzerland.

Background: Coronary artery fistula (CAF) is an abnormal communication between the termination of a coronary artery or its branches and a cardiac chamber, a great vessel or other vascular structure. Symptomatic patients with large CAF should undergo surgical or percutanous closure of the fistula at the drainage site while still the debate on closing asymptomatic CAF and re-openening symptomatic occluded CAF is ongoing.

Case Summary: We are reporting a 30-year-old male patient with no previous medical history presented as non-ST segment elevation myocardial Infarction. Read More

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December 2018

Preoperative Myocardial Troponin T Elevation is Associated with the Fracture Type in Patients with Proximal Femoral Fracture.

Scand J Surg 2018 Dec 6:1457496918816928. Epub 2018 Dec 6.

1 Heart Center, Turku University Hospital, Turku, Finland.

Background And Aims:: Cardiovascular complications are common in hip fracture patients but the role of fracture type and operative method in these is unclear. This prospective cohort study aimed to evaluate the impact of fracture- and operative characteristics on perioperative cardiovascular complications and prognosis in unselected hip fracture patients.

Material And Methods:: During a 7-month trial registration period, a population of 197 consecutive hip fracture patients (median age 84 years) diagnosed with femoral neck or pertrochanteric fracture was formed. Read More

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December 2018

Prevalence of pharmacogenomic variants affecting the efficacy of clopidogrel therapy in the Hispanic Community Health Study/Study of Latinos cohort.

Pharmacogenomics 2018 Dec 6. Epub 2018 Dec 6.

Department of Epidemiology & Population Health, Albert Einstein College of Medicine, Bronx, NY 10461, USA.

Purpose: Although clopidogrel is the most widely used oral P2Y12 receptor antagonist, up to 10% of acute coronary syndrome patients treated with clopidogrel will experience a recurrent myocardial infarction and 2-3% will experience stent thrombosis within 1 year. The purpose of this research is to describe the prevalence of pharmacogene variants associated with clopidogrel responsiveness (CYP2C19, B4GALT2, ABCB1, PON1, CES1 and P2RY12) in Hispanic/Latino patients of diverse backgrounds.

Methods: Minor allele frequencies of nine variants from participants of Hispanic Community Health Study/Study of Latinos were compared between subpopulations as well as to continental ancestry references using z-test for independent proportions. Read More

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December 2018

Cardiotoxicity and myocardial infarction-associated DNA damage induced by thiamethoxam in vitro and in vivo: Protective role of Trigonella foenum-graecum seed-derived polysaccharide.

Environ Toxicol 2018 Dec 5. Epub 2018 Dec 5.

Laboratory of Enzyme Engineering and Microbiology, National Engineering School of Sfax, University of Sfax, Sfax, Tunisia.

The risk of pesticides on the human health and environment has drawn increasing attention. Today, new tools are developed to reduce pesticide adverse effects. This study aimed to evaluate the toxicity induced by, thiamethoxam (TMX), and the cytoprotective effect of a novel polysaccharide, named fenugreek seed water polysaccharide (FWEP) in vitro using H9c2 cardiomyoblastes and in vivo using Wistar rat model. Read More

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December 2018

Perinatal changes in fetal cardiac geometry and function in gestational diabetic pregnancies at term.

Ultrasound Obstet Gynecol 2018 Dec 6. Epub 2018 Dec 6.

Molecular & Clinical Sciences Research Institute, St George's University of London.

Objective: To evaluate the effect of gestational diabetes mellitus (GDM) on fetal and neonatal cardiac geometry and function around the time of birth.

Methods: A prospective study of 75 pregnant women delivering at term, comprising of 54 normal pregnancies and 21 with a diagnosis GDM. Fetal and neonatal conventional cardiac indices, spectral tissue Doppler and 2D speckle tracking imaging were performed a few days before and within hours of birth. Read More

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December 2018
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Plasmonic ELISA for Sensitive Detection of Disease Biomarkers with a Smart Phone-Based Reader.

Nanoscale Res Lett 2018 Dec 5;13(1):397. Epub 2018 Dec 5.

Institute of Biotranslational Medicine, Jinan University, Guangzhou, 510632, People's Republic of China.

Serum myoglobin is one of the earliest markers for the diagnosis of acute myocardial infarction. It is, therefore, critical to develop a point-of-care testing technology for myoglobin detection. In this work, we reported a sensitive plasmonic immunoassay-based on enzyme-mediated localized surface plasmon resonance change of gold nanorods for the point-of-care testing detection of myoglobin. Read More

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December 2018

Diastolic wall strain as a predictor of age-related cardiovascular events in patients with preserved left ventricular ejection fraction.

Heart Vessels 2018 Dec 5. Epub 2018 Dec 5.

Division of Cardiology, Department of Medicine II, Kansai Medical University, 2-5-1, Shin-machi, Hirakata, 573-1010, Osaka, Japan.

Diastolic wall strain (DWS) was reported as a simple and feasible echocardiographic index in assessing left ventricular (LV) diastolic stiffness. We sought to evaluate whether DWS predicts age-related cardiovascular events. Patients referred for transthoracic echocardiogram, those with preserved LV ejection fraction and no clinical heart failure were studied. Read More

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December 2018

The clinical impact of sex differences on ischemic postconditioning during primary percutaneous coronary intervention: a POST (the effects of postconditioning on myocardial reperfusion in patients with ST-segment elevation myocardial infarction) substudy.

Heart Vessels 2018 Dec 5. Epub 2018 Dec 5.

Kyungpook National University Hospital, Daegu, South Korea.

The POST (the effects of postconditioning on myocardial reperfusion in patients with ST-Segment elevation myocardial infarction) study showed that ischemic postconditioning did not improve myocardial reperfusion in patients with ST-segment elevation myocardial infarction (STEMI) undergoing primary percutaneous coronary intervention (PCI). However, it has not been determined whether postconditioning is effective in women. This study sought to evaluate the impact of sex differences on ischemic postconditioning during the primary PCI. Read More

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December 2018

Comparison of native myocardial T1 and T2 mapping at 1.5T and 3T in healthy volunteers : Reference values and clinical implications.

Wien Klin Wochenschr 2018 Dec 5. Epub 2018 Dec 5.

Department of Radiology, Paracelsus Medical University, Müllner Hauptstraße 48, 5020, Salzburg, Austria.

Background: Myocardial native T1 and T2 mapping are promising techniques for quantitative assessment of diffuse myocardial pathologies; however, due to conflicting data regarding normal values, routine clinical implementation of this method is still challenging.

Methods: To evaluate this situation during daily clinical practice the characteristics of normal values obtained in 60 healthy volunteers who underwent magnetic resonance imaging (MRI) scans on 1.5T and 3T scanners were studied. Read More

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December 2018
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6-Gingerol Protects Heart by Suppressing Myocardial Ischemia/Reperfusion Induced Inflammation via the PI3K/Akt-Dependent Mechanism in Rats.

Evid Based Complement Alternat Med 2018 5;2018:6209679. Epub 2018 Nov 5.

Department of Integrated Traditional Chinese and Western Medicine, First Affiliated Hospital of Guilin Medical University, Guilin 541001, Guangxi Zhuang Autonomous Region, China.

Our previous study has demonstrated that 6-Gingerol (6-G) could alleviate myocardial ischemia/reperfusion injury (MIRI). However, the molecular mechanism underlying the process of myocardial ischemia/reperfusion (I/R) injury alleviation by 6-G remains unelucidated. The objective of the present study is to further investigate the potential mechanism for 6-G to alleviate MIRI in rats. Read More

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November 2018

Exosomes and miRNA-Loaded Biomimetic Nanovehicles, a Focus on Their Potentials Preventing Type-2 Diabetes Linked to Metabolic Syndrome.

Front Immunol 2018 21;9:2711. Epub 2018 Nov 21.

UMR-1280 Inra and University of Nantes, Nantes, France.

Exosomes are small membrane vesicles of 30-150 nm, members of the extracellular vesicle family and secreted by various cell types. Different studies describe specific microRNA (miRNA) with altered expression in serum and/or plasma of patients suffering from diabetes or metabolic syndrome. Diabetic cardiomyocyte-derived exosomes loaded with miRNAs like miR-320-3p (or 320a) have been shown regulating angiogenesis on endothelial cell cultures. Read More

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November 2018
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Nanotechnology, an alternative with promising prospects and advantages for the treatment of cardiovascular diseases.

Int J Nanomedicine 2018 9;13:7349-7362. Epub 2018 Nov 9.

Department of Cardiovascular Surgery, West China Hospital, Sichuan University, Chengdu, China,

Cardiovascular diseases (CVDs) are one of the most important causes of mortality and affecting the health status of patients. At the same time, CVDs cause a huge health and economic burden to the whole world. Although a variety of therapeutic drugs and measures have been produced to delay the progress of the disease and improve the quality of life of patients, most of the traditional therapeutic strategies can only cure the symptoms and cannot repair or regenerate the damaged ischemic myocardium. Read More

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November 2018

A systematic review and network meta-analysis of the comparative efficacy of angiotensin-converting enzyme inhibitors and angiotensin receptor blockers in hypertension.

J Hum Hypertens 2018 Dec 5. Epub 2018 Dec 5.

3rd Department of Internal Medicine, Hypertension-24h Ambulatory Blood Pressure Monitoring Center, Papageorgiou General Hospital, Aristotle University of Thessaloniki, Thessaloniki, Greece.

Angiotensin-converting enzyme inhibitors and angiotensin receptor blockers are drugs commonly used for the treatment of hypertension. However, studies on their comparative efficacy have not been extensively investigated. The current systematic review and network meta-analysis studied the comparative efficacy of the two antihypertensive treatment categories in reducing blood pressure, mortality, and morbidity in essential hypertension patients. Read More

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December 2018

Pressure Overload Impairs Cardiac Function in Long-Chain Fatty Acid Transporter CD36-Knockout Mice.

Int Heart J 2018 Dec 5. Epub 2018 Dec 5.

Rinku General Medical Center.

CD36 is one of the important transporters of long-chain fatty acids (LCFAs) in the myocardium. We previously reported that CD36-deficient patients demonstrate a marked reduction of myocardial uptake of LCFA, while myocardial glucose uptake shows a compensatory increase, and are often accompanied by cardiomyopathy. However, the molecular mechanisms and functional role of CD36 in the myocardium remain unknown. Read More

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December 2018
2 Reads

Natriuretic Peptide Processing in Patients with and Without Left Ventricular Dysfunction.

Int Heart J 2018 Dec 5. Epub 2018 Dec 5.

Cardiovascular Center, Onze Lieve Vrouw Ziekenhuis.

This study aimed to examine the relationship between corin expression and circulating brain natriuretic peptide in patients with left ventricular (LV) dysfunction.Circulating levels of B-type natriuretic peptide (BNP) can be an indicator of LV dysfunction. The 32-amino-acid BNP is cleaved by corin, a cardiac serine protease, from its108-amino-acid pro-brain natriuretic peptide (proBNP) precursor. Read More

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December 2018

CAP2 mutation leads to impaired actin dynamics and associates with supraventricular tachycardia and dilated cardiomyopathy.

J Med Genet 2018 Dec 5. Epub 2018 Dec 5.

The Shraga Segal Department of Microbiology, Immunology and Genetics, Faculty of Health Sciences, Ben Gurion University, Beer Sheva, Israel.

Background: Dilated cardiomyopathy (DCM) is a primary myocardial disease leading to contractile dysfunction, progressive heart failure and excessive risk of sudden cardiac death. Around half of DCM cases are idiopathic, and genetic factors seem to play an important role.

Aim: We investigated a possible genetic cause of DCM in two consanguineous children from a Bedouin family. Read More

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December 2018

Identification of ILK as a critical regulator of VEGFR3 signalling and lymphatic vascular growth.

EMBO J 2018 Dec 5. Epub 2018 Dec 5.

Institute of Metabolic Physiology, Heinrich Heine University Düsseldorf, Düsseldorf, Germany

Vascular endothelial growth factor receptor-3 (VEGFR3) signalling promotes lymphangiogenesis. While there are many reported mechanisms of VEGFR3 activation, there is little understanding of how VEGFR3 signalling is attenuated to prevent lymphatic vascular overgrowth and ensure proper lymph vessel development. Here, we show that endothelial cell-specific depletion of integrin-linked kinase (ILK) in mouse embryos hyper-activates VEGFR3 signalling and leads to overgrowth of the jugular lymph sacs/primordial thoracic ducts, oedema and embryonic lethality. Read More

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December 2018

Bioactive scaffolds in stem-cell-based therapies for cardiac repair: protocol for a meta-analysis of randomized controlled preclinical trials in animal myocardial infarction models.

Syst Rev 2018 Dec 5;7(1):225. Epub 2018 Dec 5.

Division of Cardiology and Cardiac Surgery, McGill University Health Centre, Montreal, Quebec, Canada.

Background: Acute myocardial infarction (MI) remains one of the leading causes of death worldwide with no curative therapy available. Stem cell therapies have been gaining interest as a means to repair the cardiac tissue after MI and prevent the onset of heart failure. Many in vivo reports suggest that the use of stem cells is promising, yet clinical trials suggest that the cells fail to integrate into the native tissue, resulting in limited improvements in cardiac function and repair. Read More

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December 2018
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Uniqueness of local myocardial strain patterns with respect to activation time and contractility of the failing heart: a computational study.

Biomed Eng Online 2018 Dec 5;17(1):182. Epub 2018 Dec 5.

Department of Biomedical Engineering, CARIM School for Cardiovascular Diseases, Maastricht University Medical Center, Maastricht, The Netherlands.

Background: Myocardial deformation measured by strain is used to detect electro-mechanical abnormalities in cardiac tissue. Estimation of myocardial properties from regional strain patterns when multiple pathologies are present is therefore a promising application of computer modelling. However, if different tissue properties lead to indistinguishable strain patterns ('degeneracy'), the applicability of any such method will be limited. Read More

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December 2018

Trends of Cardiovascular Risk Factors in Patients With Acute Myocardial Infarction: Soroka Acute Myocardial Infarction II (SAMI II) Project.

Angiology 2018 Dec 5:3319718816479. Epub 2018 Dec 5.

3 Department of Cardiology, Rabin Medical Center, Petah Tikva, Israel; Sackler Faculty of Medicine, Tel Aviv University, Tel Aviv, Israel.

Conclusions:: The last decade, patients with AMI became older with increased burden of CVRFs. Framingham risk score increased among patients with NSTEMI and decreased in patients with STEMI. These trends impact on risk stratification and secondary prevention programs. Read More

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December 2018

Predictors of Mortality After Percutaneous Coronary Intervention in Patients With Acute Myocardial Infarction.

Angiology 2018 Dec 5:3319718816510. Epub 2018 Dec 5.

2 Department of Cardiology, Faculty of Medicine, Mugla Sitki Kocman University, Mugla, Turkey.

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December 2018

Comparative Effectiveness of the Core Components of Cardiac Rehabilitation on Mortality and Morbidity: A Systematic Review and Network Meta-Analysis.

J Clin Med 2018 Dec 4;7(12). Epub 2018 Dec 4.

Toronto Health Economics and Technology Assessment (THETA) Collaborative, 200 Elizabeth Street, Toronto, ON M5G 2C4, Canada.

A systematic review and network meta-analysis (NMA) of randomized controlled trials (RCTs) evaluating the core components of cardiac rehabilitation (CR), nutritional counseling (NC), risk factor modification (RFM), psychosocial management (PM), patient education (PE), and exercise training (ET)) was undertaken. Published RCTs were identified from database inception dates to April 2017, and risk of bias assessed using Cochrane's tool. Endpoints included mortality (all-cause and cardiovascular (CV)) and morbidity (fatal and non-fatal myocardial infarction (MI), coronary artery bypass surgery (CABG), percutaneous coronary intervention (PCI), and hospitalization (all-cause and CV)). Read More

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December 2018

Synthesis of novel gallium-68 labeled rhodamine: A potential PET myocardial perfusion agent.

Appl Radiat Isot 2018 Sep 8;144:29-33. Epub 2018 Sep 8.

Cyclotron and Radiopharmaceuticals Department, King Faisal Specialist Hospital and Research Centre, P.O. Box 3354, Riyadh 11211, Saudi Arabia.

Myocardial perfusion imaging (MPI) is one of the most commonly performed investigations in nuclear medicine studies. Due to the physical properties of the positron emitter gallium-68 (Ga) and its availability from Ge/Ga generator, together with the well-known coordination chemistry, we have synthesized Ga-NOTA- and Ga-NODAGA-rhodamine conjugates using a straightforward and a one-step simple reaction. Radiochemical yields were greater than 95% (decay corrected), with total synthesis time of less than 30 min. Read More

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September 2018

Fecal Microbiota Transplantation Alleviates Myocardial Damage in Myocarditis by Restoring the Microbiota Composition.

Pharmacol Res 2018 Nov 30. Epub 2018 Nov 30.

Department of Cardiology, Union Hospital, Tongji Medical College, Huazhong University of Science and Technology, China. Electronic address:

Myocarditis can be caused by several infectious and noninfectious causes. Treatment for myocarditis is still a difficult task in clinical practice. The gut microbiota is related to cardiovascular diseases such as atherosclerosis and hypertension. Read More

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November 2018
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