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    Oral health and cardiovascular disease risk in a cohort of periodontitis patients.
    Atherosclerosis 2017 May 11;262:101-106. Epub 2017 May 11.
    Department of Medical Sciences, Uppsala University, Uppsala, Sweden.
    Background And Aims: The aim of this study was to determine whether oral health is uniformly associated with three different cardiovascular diseases (CVDs), including myocardial infarction (MI), stroke, and heart failure (HF), which has not been studied previously.

    Methods: A full mouth investigation was performed in 8999 individuals referred to a specialized periodontology clinic between 1979 and 2012. The number of deepened pockets (NDP), number of teeth (NT), and bleeding on probing (BOP) were investigated. Read More

    Factors associated with compliance to AHA/ACC performance measures in a myocardial infarction system of care in Brazil.
    Int J Qual Health Care 2017 May 20:1-8. Epub 2017 May 20.
    Serviço de Cardiologia e Cirurgia Cardiovascular e Centro de Telessaúde do Hospital das Clínicas da UFMG, Avenida Professor Alfredo Balena 110, Belo Horizonte, MG 30130-100, Brazil.
    Objective: To evaluate compliance with American Heart Association/American College of Cardiology (AHA/ACC) performance measures for adults with acute myocardial infarction (AMI) and to investigate the factors associated with compliance, in an AMI System of Care in Brazil.

    Design: Observational longitudinal study.

    Setting: A high-complexity University Hospital, part of the AMI System of Care implemented in Belo Horizonte, Brazil, in 2010. Read More

    Effect of Statin Treatment vs Usual Care on Primary Cardiovascular Prevention Among Older Adults: The ALLHAT-LLT Randomized Clinical Trial.
    JAMA Intern Med 2017 May 22. Epub 2017 May 22.
    Division of Geriatric Medicine and Palliative Care, Department of Medicine, New York University School of Medicine, New York.
    Importance: While statin therapy for primary cardiovascular prevention has been associated with reductions in cardiovascular morbidity, the effect on all-cause mortality has been variable. There is little evidence to guide the use of statins for primary prevention in adults 75 years and older.

    Objectives: To examine statin treatment among adults aged 65 to 74 years and 75 years and older when used for primary prevention in the Lipid-Lowering Trial (LLT) component of the Antihypertensive and Lipid-Lowering Treatment to Prevent Heart Attack Trial (ALLHAT-LLT). Read More

    Antiplatelet Therapy and Clinical Outcomes Following Myocardial Infarction Among Patients in a U.S. Employer-Based Insurance Database.
    J Manag Care Spec Pharm 2017 Jun;23(6):684-690
    2 University of North Carolina, Chapel Hill.
    Background: Estimates of residual cardiovascular risks among patients who have experienced a recent acute myocardial infarction (MI) are predominantly derived from secondary prevention trial populations, patient registries, and population-based cohorts.

    Objective: To generate real-world evidence of antiplatelet treatment and recurrent events following MI in patients on antiplatelet treatment among commercial, employer-based insured patients in a large administrative database.

    Methods: This was a retrospective cohort claims database study using the Truven Health MarketScan Commercial Claims and Encounters and Medicare Supplemental databases between 2007-2011. Read More

    Genetic Susceptibility Contributing to Periodontal and Cardiovascular Disease.
    J Dent Res 2017 Jun 22;96(6):610-617. Epub 2017 Mar 22.
    1 Department of Prosthetic Dentistry, Center for Dental and Oral Medicine, University Medical Center Hamburg-Eppendorf, Hamburg, Germany.
    Periodontal disease (PD) and coronary artery disease (CAD) are common diseases characterized by an overaggressive inflammatory response to diverse stimuli. Whereas PD leads to destruction of the tooth-supporting structures, CAD is a chronic inflammatory condition ultimately causing myocardial infarction via narrowing and occluding of blood vessels. Classical twin studies led to the conclusion that both complex diseases have a similar degree of heritability and that a significant fraction of the genetic factors accounting for this heritability is shared. Read More

    Basal hyperinsulinemia beyond a threshold predicts major adverse cardiac events at 1 year after coronary angiogram in type 2 diabetes mellitus: a retrospective cohort study.
    Diabetol Metab Syndr 2017 19;9:38. Epub 2017 May 19.
    Department of Internal Medicine, Kasturba Medical College, Manipal University, Mangalore, Karnataka 575001 India.
    Background: There is a substantial reduction in cardiovascular related morbidity and mortality in the general population attributed to improved treatment of cardiac risk factors and disease, the same magnitude of benefit has not been observed in those with diabetes mellitus. The aim of the present study was to evaluate factors associated with the cardiac outcome at 1 year after coronary angiogram in patients with type 2 diabetes mellitus and to compare the outcomes with nondiabetics.

    Methods: A retrospective cohort study was carried out in subjects who underwent coronary angiogram for an evaluation of CAD, with follow-up data available for period of 12 months. Read More

    Targeting Adenosine Receptors for the Treatment of Cardiac Fibrosis.
    Front Pharmacol 2017 5;8:243. Epub 2017 May 5.
    Monash Institute of Pharmaceutical Sciences, Monash University, ParkvilleVIC, Australia.
    Adenosine is a ubiquitous molecule with key regulatory and cytoprotective mechanisms at times of metabolic imbalance in the body. Among a plethora of physiological actions, adenosine has an important role in attenuating ischaemia-reperfusion injury and modulating the ensuing fibrosis and tissue remodeling following myocardial damage. Adenosine exerts these actions through interaction with four adenosine G protein-coupled receptors expressed in the heart. Read More

    Normalization of Diffuse ST-Depression with aVR Elevation After Rehydration in a Patient with Severe Aortic Stenosis.
    Am J Case Rep 2017 May 22;18:563-567. Epub 2017 May 22.
    Center for Medicine.
    BACKGROUND Isolated ST elevation in lead aVR in combination with global ST depression with normalization after rehydration is a unique electrocardiographic pattern that is associated with a broad range of diagnoses. Its association with left main coronary artery disease and other acute coronary syndromes suggest the need for early and aggressive cardiac evaluation. CASE REPORT A 53-year-old man presented with altered mental status and loss of consciousness. Read More

    [The changing sex differences in life expectancy in Spain (1980-2012): decomposition by age and cause].
    Gac Sanit 2017 May 19. Epub 2017 May 19.
    Departamento de Derecho del Estado y Sociología, Universidad de Málaga, Málaga, España.
    Objective: To calculate and analyse the contributions of changes in mortality by age groups and selected causes of death to sex differences in life expectancy at birth in Spain from 1980 to 2012.

    Methods: Cross-sectional study with three time points (1980, 1995, and 2012). We used data from Human Cause-of-Death Database and Human Mortality Database. Read More

    Outcomes of patients with myocardial infarction who underwent orbital atherectomy for severely calcified lesions.
    Cardiovasc Revasc Med 2017 May 7. Epub 2017 May 7.
    Cardiology Department, St. Francis Hospital-The Heart Center, Roslyn, NY, USA.
    Objectives: This study analyzed the outcomes of patients who presented with non-ST-elevation myocardial infarction (NSTEMI) and subsequently underwent orbital atherectomy for severe coronary artery calcification (CAC).

    Background: Patients who present with NSTEMI have increased risk for death and recurrent MI after percutaneous coronary intervention (PCI). Patients with severe CAC have worse outcomes after PCI. Read More

    Revascularization methods in spontaneous coronary artery dissection: A focused review.
    Cardiovasc Revasc Med 2017 May 12. Epub 2017 May 12.
    MedStar Heart and Vascular Institute, MedStar Washington Hospital Center, Washington, D.C.
    Spontaneous coronary artery dissection (SCAD) is becoming widely recognized as an important cause of myocardial infarction, particularly in younger women. Tendency toward conservative management has been primarily based on observational data. Intervention is recommended when coronary blood flow is compromised and high risk features such as left main involvement, ongoing ischemia, or hemodynamic or electrical instability are present. Read More

    Correlation and prognostic role of neutrophil to lymphocyte ratio and SYNTAX score in patients with acute myocardial infarction treated with percutaneous coronary intervention: A six-year experience.
    Cardiovasc Revasc Med 2017 May 12. Epub 2017 May 12.
    Department of Cardiology, Santa Maria della Misericordia Hospital, Rovigo, Italy. Electronic address:
    Background/purpose: The neutrophil/lymphocyte ratio (NLR) has been proposed as a prognostic marker in acute myocardial infarction (AMI). The aim of our study is to demonstrates the correlation between SYNTAX score (SXs) and NLR and its association with 1-year cardiovascular (CV) mortality in patients with ST-segment elevation myocardial infarction (STEMI) or non-ST-segment elevation myocardial infarction (NSTEMI) treated with percutaneous coronary intervention (PCI).

    Methods/materials: Over 6 consecutive years, (1st January 2010 and 1st January 2016) 6560 patients (4841 males and 1719 females, mean age 64. Read More

    Glycocalyx shedding is markedly increased during the acute phase of Takotsubo cardiomyopathy.
    Int J Cardiol 2017 Apr 28. Epub 2017 Apr 28.
    The Queen Elizabeth Hospital, Department of Cardiology, Australia; The University of Adelaide, Australia. Electronic address:
    Background: Acute myocardial infarction (AMI) and other forms of myocardial acute oxidative stress are associated with variable "shedding" of the endothelial glycocalyx (GCS) which can be quantitated ex vivo by release into plasma of glycocalyx components such as Syndecan-1 (SD-1). Previous studies have implicated release of both catecholamines and BNP as potential accentuating factors in GCS: since these are prominent aspects of the pathogenesis of Takotsubo cardiomyopathy (TTC), we hypothesised that TTC is associated with increased GCS and the extent of GCS is predictable on the basis of NT-proBNP and catecholamine releases.

    Methods: SD-1 concentrations were measured in 48 TTC patients acutely and after 3months, and compared with those in 12 healthy controls, and 17 patients with AMI. Read More

    Mortality and Atrial Fibrillation in the FIACA Study: Evidence of a Differential Effect According to Admission Diagnosis.
    Rev Esp Cardiol (Engl Ed) 2017 May 18. Epub 2017 May 18.
    Unidad de Investigación, Programa de Investigación en Enfermedades Cardiovasculares PERICLES, Servicio Extremeño de Salud, Área de Salud Don Benito-Villanueva, Villanueva de la Serena, Badajoz, Spain. Electronic address:
    Introduction And Objectives: Atrial fibrillation (AF) is an independent risk factor for mortality in several diseases. However, data published in acute decompensated heart failure (DHF) are contradictory. Our objective was to investigate the impact of AF on mortality in patients admitted to hospital for DHF compared with those admitted for other reasons. Read More

    Comparative Effectiveness and Safety of Apixaban and Vitamin K Antagonist Therapy in Patients with Nonvalvular Atrial Fibrillation Treated in Routine German Practice.
    Heart Lung Circ 2017 May 3. Epub 2017 May 3.
    Hospital Oldenburg, Department of Cardiology, Oldenburg, Germany.
    Background: Scarce data comparing real-world outcomes between apixaban and vitamin K antagonist (VKA) users with nonvalvular atrial fibrillation (NVAF) are available. We sought to assess the effectiveness and safety of newly-initiated apixaban vs. VKA in German NVAF patients. Read More

    (18)F-sodium fluoride positron emission tomography for molecular imaging of coronary atherosclerosis based on computed tomography analysis.
    Atherosclerosis 2017 Apr 29. Epub 2017 Apr 29.
    Department of Cardiovascular Medicine, Hiroshima University Graduate School of Biomedical and Health Sciences, Hiroshima, Japan.
    Background And Aims: We aimed at evaluating the relation of (18)F-sodium fluoride ((18)F-NaF) uptake on positron emission tomography (PET) to coronary atherosclerosis detected and assessed by computed tomography (CT).

    Methods: Thirty-two patients with one or more coronary atherosclerotic lesions detected on cardiac CT underwent (18)F-NaF PET/CT. Each coronary atherosclerotic lesion was evaluated on CT angiography for plaque types (calcified plaque [CP], non-calcified plaque [NCP], partially calcified plaque [PCP]), and the presence of CT-based high-risk features (minimum CT density <30 Hounsfield units and vascular remodeling index >1. Read More

    Carotid Stenting in Patients With High Risk Versus Standard Risk for Open Carotid Endarterectomy (REAL-1 Trial).
    Am J Cardiol 2017 Apr 26. Epub 2017 Apr 26.
    Angiology and Vascular Surgery Department of Getafe University Hospital, Getafe, Madrid, Spain.
    Carotid stenting (CAS) has been mainly offered to those patients considered at "high risk" for open carotid endarterectomy based on available data from large randomized clinical trials. However, several recent studies have called medical "high risk" into question for CAS indication. The REAL-1 trial evaluated the safety and perioperative and long-term effectiveness in patients with significant carotid artery stenosis with "high-risk" criteria treated with CAS and proximal protection device (MOMA) compared with those with standard surgical-risk features. Read More

    Pulmonary Flow as an Improved Method for Determining Cardiac Output in Mice after Myocardial Infarction.
    J Am Soc Echocardiogr 2017 Jun;30(6):612-623.e1
    Department of Human Health and Nutritional Sciences, University of Guelph, Guelph, Ontario, Canada. Electronic address:
    Background: Echocardiography is a valuable noninvasive technique to estimate cardiac output (CO) from the left ventricle (LV) not only in clinical practice but also in small-animal experiments. CO is used to grade cardiac function and is especially important when investigating cardiac injury (e.g. Read More

    Risk classification of highly sensitive troponin I predict presence of vulnerable plaque assessed by dual source coronary computed tomography angiography.
    Int J Cardiovasc Imaging 2017 May 20. Epub 2017 May 20.
    Department of Radiology, The First Affiliated Hospital of China Medical University, 155 Nanjing Bei St, Heping District, Shenyang, China.
    Patients presenting to the emergency department with acute chest pain, negative conventional troponin and electrocardiogram require serial testing to rule out acute coronary syndrome (ACS). We studied the association of highly sensitive troponin (hsTn) I with vulnerable plaque features as detected by coronary dual source computed tomography angiography (DSCTA) and determined whether hsTn I at the time of presentation combined with early DSCTA could improve classification of patients as high-risk or low risk for ACS. We included 220 patients with acute chest pain, negative electrocardiogram and conventional troponin who underwent DSCTA and had hsTn I measured at the time of presentation. Read More

    Evaluating the role of autologous mesenchymal stem cell seeded on decellularized pericardium in the treatment of myocardial infarction: an animal study.
    Cell Tissue Bank 2017 May 20. Epub 2017 May 20.
    Pediatric Urology and Regenerative Medicine Research Center, Section of Tissue Engineering and Stem Cells Therapy, Children's Hospital Medical Center, Tehran University of Medical Sciences, No. 62, Dr. Qarib's Street, Keshavarz Boulevard, Tehran, 1419433151, Iran.
    Inappropriate left ventricular remodeling following myocardial infarction (MI) can result in subsequent severe dysfunction. In this study, we tested the hypothesis that decellularized pericardium (DP) or seeded pericardial patch with autologous adipose-derived mesenchymal stem cells (ADMSCs) could be safely used in a MI scar and could improve heart function. Twelve rabbits were randomly divided into three equal groups. Read More

    Intervendor Differences in the Accuracy of Detecting Regional Functional Abnormalities: A Report From the EACVI-ASE Strain Standardization Task Force.
    JACC Cardiovasc Imaging 2017 May 11. Epub 2017 May 11.
    Department of Cardiovascular Diseases, University Hospital Leuven, Leuven, Belgium. Electronic address:
    Objectives: The purpose of this study was to compare the accuracy of vendor-specific and independent strain analysis tools to detect regional myocardial function abnormality in a clinical setting.

    Background: Speckle tracking echocardiography has been considered a promising tool for the quantitative assessment of regional myocardial function. However, the potential differences among speckle tracking software with regard to their accuracy in identifying regional abnormality has not been studied extensively. Read More

    Long-Term Prognosis of Patients With Intramural Course of Coronary Arteries Assessed With CT Angiography.
    JACC Cardiovasc Imaging 2017 May 11. Epub 2017 May 11.
    Department of Cardiology, Leiden University Medical Center, Leiden, the Netherlands. Electronic address:
    Objectives: The aim of the present study was to evaluate, in low-to-intermediate pre-test probability patients who were referred for coronary computed tomography angiography (CTA) and did not show obstructive coronary artery disease (CAD), whether an intramural course of a coronary artery is associated with worse outcome compared with patients without an intramural course of the coronary arteries.

    Background: The prognostic value of an intramural course of the coronary arteries on coronary CTA in patients without obstructive CAD is not well-known.

    Methods: The study population consisted of 947 patients with a low-to-intermediate pre-test probability who were referred for coronary CTA and who did not have obstructive CAD. Read More

    Prognostic Value of Coronary CT Angiography With Selective PET Perfusion Imaging in Coronary Artery Disease.
    JACC Cardiovasc Imaging 2017 May 15. Epub 2017 May 15.
    Turku PET Centre, University of Turku, Turku, Finland; Department of Clinical Physiology, Nuclear Medicine and PET, Turku University Hospital, Turku, Finland. Electronic address:
    Objectives: The purpose of this study was to evaluate the prognostic value of sequential hybrid imaging strategy in which positron emission tomography (PET) perfusion imaging is performed selectively in patients with suspected obstructive coronary artery disease (CAD) on coronary computed tomography angiography (CTA).

    Background: Coronary CTA is an accurate diagnostic test for excluding obstructive CAD. However, the positive predictive value is suboptimal. Read More

    Outcomes of open and endovascular lower extremity revascularization in active smokers with advanced peripheral arterial disease.
    J Vasc Surg 2017 Jun;65(6):1680-1689
    Division of Vascular and Endovascular Surgery, Department of Surgery, University of California, Irvine Medical Center, Orange, Calif. Electronic address:
    Objective: Concern over perioperative and long-term durability of lower extremity revascularizations among active smokers is a frequent deterrent for vascular surgeons to perform elective lower extremity revascularization. In this study, we examined perioperative outcomes of lower extremity endovascular (LEE) revascularization and open lower extremity bypass (LEB) in active smokers with intermittent claudication (IC) and critical limb ischemia (CLI).

    Methods: Active smokers undergoing LEE or LEB from 2011 to 2014 were identified in the American College of Surgeons (ACS) National Surgical Quality Improvement Program (NSQIP) targeted vascular data set. Read More

    Initial and midterm results of the Bolton Relay Thoracic Aortic Endovascular Pivotal Trial.
    J Vasc Surg 2017 Jun;65(6):1556-1566.e1
    Department of Surgery, Massachusetts General Hospital, Boston, Mass.
    Objective: To report the initial and midterm results of the Bolton Relay Thoracic Stent Graft for the endovascular treatment of thoracic aortic lesions [thoracic endovascular aortic repair (TEVAR)].

    Methods: The Bolton Relay Thoracic Aortic Endovascular Pivotal Trial was a prospective, nonrandomized, multicenter, U.S. Read More

    Outcomes in Patients Undergoing Primary Percutaneous Coronary Intervention for ST-Segment Elevation Myocardial Infarction Via Radial Access Anticoagulated With Bivalirudin Versus Heparin: A Report From the National Cardiovascular Data Registry.
    JACC Cardiovasc Interv 2017 May 11. Epub 2017 May 11.
    Virginia Commonwealth University, Richmond, Virginia.
    Objectives: The aim of this study was to compare bivalirudin with heparin as anticoagulant agents in patients with ST-segment elevation myocardial infarction treated with radial primary percutaneous coronary intervention (PCI).

    Background: Recent studies in which PCI was performed predominantly via radial access did not show bivalirudin to be superior to heparin.

    Methods: Outcomes were compared in patients with STEMI included in the National Cardiovascular Data Registry CathPCI database from 2009 to 2015 who underwent primary PCI via radial access and who were anticoagulated with bivalirudin or heparin. Read More

    Prevalence, Management, and Long-Term (6-Year) Outcomes of Atrial Fibrillation Among Patients Receiving Drug-Eluting Coronary Stents.
    JACC Cardiovasc Interv 2017 May 11. Epub 2017 May 11.
    Division of Cardiology, Asan Medical Center, University of Ulsan College of Medicine, Seoul, Korea.
    Objectives: This study sought to investigate the incidence, management, and clinical relevance of atrial fibrillation (AF) during and after percutaneous coronary intervention (PCI) with drug-eluting stents (DES) and evaluate outcomes of different antithrombotic strategies.

    Background: Uncertainty exists regarding the optimal antithrombotic strategy in patients with AF who are undergoing PCI with DES.

    Methods: Using a consecutive series of 10,027 patients who underwent DES implantation between 2003 and 2011, we evaluated the overall prevalence and clinical impact of AF. Read More

    Aspirin Versus Aspirin Plus Clopidogrel as Antithrombotic Treatment Following Transcatheter Aortic Valve Replacement With a Balloon-Expandable Valve: The ARTE (Aspirin Versus Aspirin + Clopidogrel Following Transcatheter Aortic Valve Implantation) Randomized Clinical Trial.
    JACC Cardiovasc Interv 2017 May 11. Epub 2017 May 11.
    Quebec Heart & Lung Institute, Laval University, Quebec City, Quebec, Canada.
    Objective: The aim of this study was to compare aspirin plus clopidogrel with aspirin alone as antithrombotic treatment following transcatheter aortic valve replacement (TAVR) for the prevention of ischemic events, bleeding events, and death.

    Background: Few data exist on the optimal antithrombotic therapy following TAVR.

    Methods: This was a randomized controlled trial comparing aspirin (80 to 100 mg/day) plus clopidogrel (75 mg/day) (dual-antiplatelet therapy [DAPT]) versus aspirin alone (single-antiplatelet therapy [SAPT]) in patients undergoing TAVR with a balloon-expandable valve. Read More

    Fully automatic segmentation of left ventricular anatomy in 3-D LGE-MRI.
    Comput Med Imaging Graph 2017 May 8;59:13-27. Epub 2017 May 8.
    Siemens Healthcare GmbH, Advanced Therapies, Forchheim, Germany.
    The current challenge for electrophysiology procedures, targeting the left ventricle, is the localization and qualification of myocardial scar. Late gadolinium enhanced magnetic resonance imaging (LGE-MRI) is the current gold standard to visualize regions of myocardial infarction. Commonly, a stack of 2-D images is acquired of the left ventricle in short-axis orientation. Read More

    Income disparities in healthcare use remain after controlling for healthcare need: evidence from Swedish register data on psoriasis and psoriatic arthritis.
    Eur J Health Econ 2017 May 19. Epub 2017 May 19.
    Health Technology Assessment Skåne, Skåne University Hospital, Lund, Sweden.
    We used a southern Swedish cohort of psoriasis (PSO) and psoriatic arthritis (PsA) patients and population-based referents (N = 57,800) to investigate the influence of socioeconomic and demographic factors on the probability of healthcare use and on healthcare costs when controlling for need as measured by PSO/PsA and common additional morbidities such as diabetes, depression and myocardial infarction. People with PSO/PsA were identified by ICD-10 codes in the Skåne Healthcare Register 1998-2007. Resource use and costs for years 2008-2011 were retrieved from the Skåne Healthcare Register and the Swedish Prescribed Drug Register, and socioeconomic data were retrieved from Statistics Sweden. Read More

    Exosomes in Cardiovascular Medicine.
    Cardiol Ther 2017 May 19. Epub 2017 May 19.
    School of Clinical Sciences, University of Bristol, Bristol, United Kingdom.
    Exosomes are small, extracellular membrane-bound particles that mediate intercellular transport of a cytosolic cargo. Exosomal transfer of micro-RNA can modify gene expression in targeted cells. Exosome-based endocrine/paracrine signaling has been shown to be involved in a wide range of physiological processes including those associated with cardiovascular injury and disease, but remains relatively poorly understood. Read More

    Hypoxia modulates cell migration and proliferation in placenta-derived mesenchymal stem cells.
    J Thorac Cardiovasc Surg 2017 Apr 13. Epub 2017 Apr 13.
    Division of Experimental Surgery, McGill University, Montreal, Quebec, Canada; Division of Cardiac Surgery, McGill University Health Centre, Montreal, Quebec, Canada. Electronic address:
    Objectives: For more than a decade, stem cells isolated from different tissues have been evaluated in cell therapy. Among them, the human bone marrow-derived mesenchymal stem cells (hBM-MSCs) were investigated extensively in the treatment of myocardial infarction. Recently, the human placenta-derived mesenchymal stem cells (hPD-MSCs), which are readily available from a biological waste, appear to be a viable alternative to hBM-MSCs. Read More

    Cardiovascular Protection in the Treatment of Type 2 Diabetes: A Review of Clinical Trial Results Across Drug Classes.
    Am J Med 2017 May 15. Epub 2017 May 15.
    University Heart Center, Cardiology, University Hospital Zurich, Switzerland; Center for Molecular Cardiology, University of Zurich, Switzerland.
    Patients with type 2 diabetes (T2DM) have a significantly higher risk of developing cardiovascular disease (CVD)-namely myocardial infarction, heart failure, and stroke. Despite clear advances in the prevention and treatment of CVD, the impact of T2DM on CVD outcome remains high and continues to escalate. Available evidence indicates that the risk of macrovascular complications increases with the severity of hyperglycemia, thus suggesting that the relation between metabolic disturbances and vascular damage is approximately linear. Read More

    Left ventricular mural thrombus and dual coronary embolization associated with hyperthyroid cardiomyopathy and atrial fibrillation: a case report.
    BMC Cardiovasc Disord 2017 May 19;17(1):128. Epub 2017 May 19.
    Department of Cardiology, China-Japan Union Hospital, Jilin University, Changchun, Jilin Province, 130000, China.
    Background: The majority of acute myocardial infarction (AMI) events are caused by thrombotic occlusion of the coronary artery, secondary to atherosclerotic plaque erosion or rupture. However, coronary embolism (CE), while rare, is being increasingly recognized as an important cause of AMI. We present the case of a patient with multi-site coronary artery embolization associated with hyperthyroid-related cardiomyopathy and atrial fibrillation. Read More

    Activation of cannabinoid receptor type II by AM1241 protects adipose-derived mesenchymal stem cells from oxidative damage and enhances their therapeutic efficacy in myocardial infarction mice via Stat3 activation.
    Oncotarget 2017 May 4. Epub 2017 May 4.
    Department of Cardiology, State Key Laboratory of Kidney Diseases, Chinese PLA General Hospital, Beijing, China.
    The poor survival of cells in ischemic sites diminishes the therapeutic efficacy of stem cell therapy. Previously we and others have reported that Cannabinoid receptor type II (CB2) is protective during heart ischemic injury for its anti-oxidative activity. However, whether CB2 activation could improve the survival and therapeutic efficacy of stem cells in ischemic myocardium and the underlying mechanisms remain elusive. Read More

    Relationship Between Arterial Access and Outcomes in ST-Elevation Myocardial Infarction With a Pharmacoinvasive Versus Primary Percutaneous Coronary Intervention Strategy: Insights From the STrategic Reperfusion Early After Myocardial Infarction (STREAM) Study.
    J Am Heart Assoc 2016 Jun 13;5(6). Epub 2016 Jun 13.
    Canadian VIGOUR Center, University of Alberta, Edmonton, Alberta, Canada
    Background: The effectiveness of radial access (RA) in ST-elevation myocardial infarction (STEMI) has been predominantly established in primary percutaneous coronary intervention (pPCI) with limited exploration of this issue in the early postfibrinolytic patient. The purpose of this study was to compare the effectiveness and safety of RA versus femoral (FA) access in STEMI undergoing either a pharmacoinvasive (PI) strategy or pPCI.

    Methods And Results: Within STrategic Reperfusion Early After Myocardial Infarction (STREAM), we evaluated the relationship between arterial access site and primary outcome (30-day composite of death, shock, congestive heart failure, or reinfarction) and major bleeding according to the treatment strategy received. Read More

    Oleuropein prevents the development of experimental autoimmune myocarditis in rats.
    Int Immunopharmacol 2017 May 16;48:187-195. Epub 2017 May 16.
    Department of Critical Care Medicine, Hang Zhou Red Cross Hospital, Hangzhou 310014, Zhejiang, China. Electronic address:
    Oleuropein (OLE) is a natural secoiridoid that is derived from Olea europaea. OLE possesses cardioprotective effects in experimental models of hypertension, myocardial infarction, atherosclerosis and hyperlipidaemia. In the present study, the effects of OLE on experimental autoimmune myocarditis (EAM) were evaluated. Read More

    Diving and long-term cardiovascular health.
    Occup Med (Lond) 2017 May 19. Epub 2017 May 19.
    Department of Circulation and Medical Imaging, Norwegian University of Science and Technology, NTNU, 7491 Trondheim, Norway.
    Background: Short-term cardiovascular effects from ambient pressure exposure are known. However, long-term cardiovascular effects from diving in humans have been less studied.

    Aims: To examine possible long-term cardiovascular health effects from occupational diving. Read More

    Mesenchymal stem cells sense mitochondria released from damaged cells as danger signals to activate their rescue properties.
    Cell Death Differ 2017 May 19. Epub 2017 May 19.
    Université Paris-Est, UMR-S955, UPEC, Créteil, Paris, France.
    Mesenchymal stem cells (MSCs) protect tissues against cell death induced by ischemia/reperfusion insults. This therapeutic effect seems to be controlled by physiological cues released by the local microenvironment following injury. Recent lines of evidence indicate that MSC can communicate with their microenvironment through bidirectional exchanges of mitochondria. Read More

    Wild-type p53-induced Phosphatase 1 Deficiency Exacerbates Myocardial Infarction-induced Ischemic Injury.
    Chin Med J (Engl) 2017 Jun;130(11):1333-1341
    Department of Coronary Artery Disease, State Key Laboratory of Cardiovascular Disease, Fuwai Hospital, National Center for Cardiovascular Diseases, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing 100037, China.
    Background: Myocardial infarction (MI) is a major disease burden. Wild-type p53-induced phosphatase 1 (Wip1) has been studied extensively in the context of cancer and the regulation of different types of stem cells, but the role of Wip1 in cardiac adaptation to MI is unknown. We investigated the significance of Wip1 in a mouse model of MI. Read More

    Transplantation of human villous trophoblasts preserves cardiac function in mice with acute myocardial infarction.
    J Cell Mol Med 2017 May 19. Epub 2017 May 19.
    Cyrus Tang Hematology Center and Collaborative Innovation Center of Hematology, Soochow University, Suzhou, China.
    Over the past decade, cell therapies have provided promising strategies for the treatment of ischaemic cardiomyopathy. Particularly, the beneficial effects of stem cells, including bone marrow stem cells (BMSCs), endothelial progenitor cells (EPCs), mesenchymal stem cells (MSCs), embryonic stem cells (ESCs), and induced pluripotent stem cells (iPSCs), have been demonstrated by substantial preclinical and clinical studies. Nevertheless stem cell therapy is not always safe and effective. Read More

    Potentiation of TRAP-6-induced platelet dense granule release by blockade of P2Y12 signaling with MRS2395.
    Platelets 2017 May 19:1-12. Epub 2017 May 19.
    a Department of Biomedical Engineering, School of Medicine , Oregon Health & Science University , Portland , OR , USA.
    The release of ADP from platelet dense granules and its binding to platelet P2Y12 receptors is key to amplifying the initial hemostatic response and propagating thrombus formation. P2Y12 has thus emerged as a therapeutic target to safely and effectively prevent secondary thrombotic events in patients with acute coronary syndrome or a history of myocardial infarction. Pharmacological inhibition of P2Y12 receptors represents a useful approach to better understand the signaling mediated by these receptors and to elucidate the role of these receptors in a multitude of platelet hemostatic and thrombotic responses. Read More

    Development of a novel flow cytometric immunobead array to quantify VWF:Ag and VWF:GPIbR and its application in acute myocardial infarction.
    Eur J Haematol 2017 May 18. Epub 2017 May 18.
    Jiangsu Institute of Hematology, Key Laboratory of Thrombosis and Hemostasis of Ministry of Health, The First Affiliated Hospital of Soochow University, Suzhou, China.
    Objectives: Both von Willebrand disease (VWD) and acute myocardial infarction (AMI) involve quantitative and qualitative changes in von Willebrand factor (VWF). Our objective was to develop a rapid and precise flow cytometric immunobead array (FCIA) to quantify VWF antigen (VWF:Ag) and ristocetin-triggered platelet glycoprotein Ib binding (VWF:GPIbR), and apply it in a clinical setting.

    Methods: Microbeads, coated with monoclonal antibodies for SZ29 or SZ151 IgG, were incubated with diluted plasma. Read More

    Hh signaling in regeneration of the ischemic heart.
    Cell Mol Life Sci 2017 May 18. Epub 2017 May 18.
    Chair of Internal Medicine, Cardiology and Vascular Medicine, Division of Cardiology, Department of Cardiovascular Medicine, University Hospital Münster, Albert-Schweitzer, Campus 1, Building A1, 48149, Münster, Germany.
    Myocardial infarction (MI) is caused by the occlusion of a coronary artery due to underlying atherosclerosis complicated by localized thrombosis. The blockage of blood flow leads to cardiomyocyte (CM) death in the infarcted area. Adult mammalian cardiomyocytes have little capacity to proliferate in response to injury; however, some pathways active during embryogenesis and silent during adult life are recruited in response to tissue injury. Read More

    Cardiovascular risk factors in Chiari malformation and idiopathic intracranial hypertension.
    Brain Behav 2017 May 28;7(5):e00677. Epub 2017 Mar 28.
    Department of NeurosurgeryOslo University Hospital-RikshospitaletOsloNorway.
    Objectives: Both Chiari malformation type 1 (CMI, i.e., the idiopathic caudal ectopy of cerebellar tonsils into foramen magnum) and idiopathic intracranial hypertension (IIH) are characterized by reduced intracranial compliance (ICC) due to disturbed circulation of cerebrospinal fluid (CSF). Read More

    11β-HSD1 suppresses cardiac fibroblast CXCL2, CXCL5 and neutrophil recruitment to the heart post MI.
    J Endocrinol 2017 Jun;233(3):315-327
    University/BHF Centre for Cardiovascular ScienceUniversity of Edinburgh, Queen's Medical Research Institute, Edinburgh, UK
    We have previously demonstrated that neutrophil recruitment to the heart following myocardial infarction (MI) is enhanced in mice lacking 11β-hydroxysteroid dehydrogenase type 1 (11β-HSD1) that regenerates active glucocorticoid within cells from intrinsically inert metabolites. The present study aimed to identify the mechanism of regulation. In a mouse model of MI, neutrophil mobilization to blood and recruitment to the heart were higher in 11β-HSD1-deficient (Hsd11b1(-)(/)(-) ) relative to wild-type (WT) mice, despite similar initial injury and circulating glucocorticoid. Read More

    QRS/T-Wave and Calcium Alternans in a Type I Diabetic Mouse Model for Spontaneous Post Myocardial Infarction Ventricular Tachycardia: A Mechanism for the Antiarrhythmic Effect of Statins.
    Heart Rhythm 2017 May 15. Epub 2017 May 15.
    Tufts Medical Center, Tufts University School of Medicine, Boston, MA; Molecular Cardiology Research Institute, Tufts Medical Center, Boston, MA; Cardiovascular Division, Cardiovascular Center, Department of Medicine, Tufts Medical Center, Boston, MA. Electronic address:
    Background: The incidence of sudden arrhythmic death is markedly increased in diabetics.

    Objective: Develop a mouse model for Post MI VT in the diabetic heart and determine the mechanism of an antiarrhythmic effect of statins.

    Methods: EKG transmitters were implanted in wild type (WT), placebo and pravastatin treated Type I diabetic Akita mice, MIs induced by coronary ligation, Ca(2+) transients studied by optical mapping, Ca(2+) transients and sparks in left VM (VM) by the Ionoptix system and confocal microscopy. Read More

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