Search Our Scientific Publications & Authors

Diabetes Res Clin Pract 2019 Feb 19. Epub 2019 Feb 19.

Consultant Endocrinologist. Nightingale Hospital, Kolkata, India.

Aim: To assess the effects DPP- 4i; SGLT2-i & GLP1-RA on CV death, MI, stroke and hHF . This is probably the first meta-analysis to assess the effects of these drugs on MI and stroke in totality, including non-fatal & fatal MI and stroke.

Methods: Scientific databases were searched for RCTs with pre-specified inclusion criteria and each end-point from the selected 13 studies was reported as an effect size (M H odds ratio) with a 95% confidence interval P value. Read More

PLoS One 2019 22;14(2):e0207979. Epub 2019 Feb 22.

CHU La Rabta, Tunis, Tunisia.

Background: The FAST-MI Tunisia registry was set up by the Tunisian Society of Cardiology and Cardiovascular Surgery to assess the demographic and clinical characteristics, management and hospital outcome of patients with ST-elevation myocardial infarction (STEMI).

Methods: Data for 459 consecutive patients (mean age 60.8 years; 88. Read More

PLoS One 2019 22;14(2):e0209502. Epub 2019 Feb 22.

Department of Cardiology, Swiss Cardiovascular Center, University Hospital Bern, Bern, Switzerland.

Background: The study aims to assess characteristics and outcomes of patients suffering a mechanical complication (MC) after ST-segment elevation myocardial infarction (STEMI) in a contemporary cohort of patients in the percutaneous coronary intervention era.

Methods And Results: This retrospective single-center cohort study encompasses 2508 patients admitted with STEMI between March 9, 2009 and June 30, 2014. A total of 26 patients (1. Read More

J Hosp Med 2019 Feb 20;14:E1-E6. Epub 2019 Feb 20.

Department of Medicine, University of California, San Francisco, California.

Background: The Veterans Health Administration (VA) reports hospital-specific 30-day risk-standardized readmission rates (RSRRs) using CMS-derived models.

Objective: The aim of this study was to examine and describe the interfacility variability of 30-day RSRRs for acute myocardial infarction (AMI), heart failure (HF), and pneumonia as a means to assess its utility for VA quality improvement and hospital comparison.

Research Design: A retrospective analysis of VA and Medicare claims data using one-year (2012) and three-year (2010-2012) data given their use for quality improvement or for hospital comparison, respectively. Read More

Eur Heart J 2019 Feb 21. Epub 2019 Feb 21.

Brigham and Women's Hospital, Heart and Vascular Center and Harvard Medical School, 75 Francis Street, Boston, MA, USA.

Aims: After percutaneous coronary intervention (PCI) in patients with atrial fibrillation, safety and efficacy with dabigatran dual therapy were evaluated in pre-specified subgroups of patients undergoing PCI due to acute coronary syndrome (ACS) or elective PCI, and those receiving ticagrelor or clopidogrel treatment.

Methods And Results: In the RE-DUAL PCI trial, 2725 patients were randomized to dabigatran 110 mg or 150 mg with P2Y12 inhibitor, or warfarin with P2Y12 inhibitor and aspirin. Mean follow-up was 14 months, 50. Read More

Clin Cardiol 2019 Feb 21. Epub 2019 Feb 21.

Department of Cardiology, University of Arizona College of Medicine- Phoenix.

Background: Cardiovascular disease (CVD) remains the leading cause of death for females in the United States accounting for over 412,000 female deaths in 2016. CVD mortality in young women <55 years old remains significantly high and greater than that in men.

Hypothesis: There is a void with regards to awareness of CVD in women. Read More

J Cell Physiol 2019 Feb 21. Epub 2019 Feb 21.

Department of Pathophysiology, School of Basic Medical Science, Central South University, Changsha, Hunan, China.

Proangiogenesis is generally regarded as an effective approach for treating ischemic heart disease. Vascular endothelial growth factor (VEGF)-A is a strong and essential proangiogenic factor. Reactive oxygen species (ROS), endoplasmic reticulum (ER) stress, and autophagy are implicated in the process of angiogenesis. Read More

Bull Exp Biol Med 2019 Feb 22. Epub 2019 Feb 22.

National Medical Research Center for Cardiology, Ministry of Health of the Russian Federation, Moscow, Russia.

Mesenchymal stromal cells from rat adipose tissue were transduced with adeno-associated viral (AAV) vector encoding stem cell factor SCF that stimulates proliferation of cardiac c-kit cells and improved cardiac function and survival of animals after myocardial infarction. Extracellular vesicles isolated from the medium conditioned by mesenchymal stromal cells by ultracentrifugation were characterized by Western blotting, transmission electron microscopy, nanoparticle tracking analysis, immunostaining, and mass spectrometry analysis. Using proteomic analysis, we identified transgenic SCF in extracellular vesicles released by AAV-modified mesenchymal stromal cells and detected some proteins specific of extracellular vesicles secreted by transduced cells. Read More

Turk J Emerg Med 2019 Jan 17;19(1):33-35. Epub 2018 Jul 17.

Department of Radiology, Medical Faculty of Bozok University, Adnan Menderes Bulvarı No:44, 66020, Yozgat, Turkey.

Introduction: In patients with ST elevation myocardial infarction (STEMI), minimizing the reperfusion time is the goal of therapy worldwide. However, the differential diagnosis is critical and when a patient is encountered with chest pain and ST elevation, STEMI should not be the only diagnosis considered. By detailed history and focused physical examination, it is possible to avoid a mistaken diagnosis. Read More

Prev Med Rep 2019 Mar 14;13:306-313. Epub 2019 Jan 14.

Department of Cardiovascular Diseases, Mayo Clinic, Rochester, MN, United States of America.

We investigated electronic health record (EHR) access as an indicator of cardiovascular health promotion by patients in their social networks, by identifying individuals who viewed their coronary heart disease (CHD) risk information in the EHR and shared this information in their social networks among various spheres of influence. In a secondary analysis of the Myocardial Infarction Genes trial, Olmsted County MN residents (2013-2015; n = 203; whites, ages 45-65 years) at intermediate CHD risk were randomized to receive their conventional risk score (CRS; based on traditional risk factors) alone or also their genetic risk score (GRS; based on 28 genomic variants). We assessed self-reported and objectively quantified EHR access via a patient portal at three and six months after risk disclosure, and determined whether this differed by GRS disclosure. Read More

Interv Med Appl Sci 2018 Dec;10(4):191-197

Department of Cardiology, Cardiovascular Research Center, Madani Heart Center, Tabriz University of Medical Sciences, Tabriz, Iran.

Background: The early identification of patients with acute inferior ST-segment elevation myocardial infarction (STEMI) with high risk features is particularly important. Acute inferior STEMI may be associated with ST-segment depression in the left precordial leads (V4-V6). This study assessed prognostic value of ST-segment depression in these left precordial leads during the admission of patients with acute inferior STEMI treated with primary percutaneous coronary intervention. Read More

Interv Med Appl Sci 2018 Dec;10(4):186-190

Department of Cardiology, Sri Jayadeva Institute of Cardiovascular Sciences and Research, Bangalore, India.

Objectives: Although rare, incidents of broken/dislodged fragment of various angioplasty hardwares, including catheters, guidewires, angioplasty balloons, and stents, are being increasingly reported in recent years. Since these broken fragments may cause life-threatening consequences for a patient, it is vital for an interventional cardiologist to be acquainted with different retrieval techniques. Here, we are reporting our observations of several incidents of device dislodgement/fracture during cardiac interventions and their retrieval using simple balloon method. Read More

Clin Med Insights Case Rep 2019 7;12:1179547619828689. Epub 2019 Feb 7.

Division of Cardiology, School of Medicine, University of Colorado, Aurora, CO, USA.

Coronary artery aneurysms (CAA) are a rare cause of acute coronary syndrome and there is little consensus as to the optimal treatment. Based on case series as well as expert opinion, surgery has been suggested as the optimal treatment for a giant CAA. Here, we present the case of a patient with recurrent myocardial infarction and severe angina due to a giant CAA, who was deemed a poor surgical candidate due to his multiple medical comorbidities. Read More

Sci Rep 2019 Feb 21;9(1):2481. Epub 2019 Feb 21.

School of Physical Education, University of Campinas - UNICAMP, Campinas, SP, Brazil.

Inflammatory processes and cardiovascular autonomic imbalance are very relevant characteristic of the enormous dynamic process that is a myocardial infarction (MI). In this sense, some studies are investigating pharmacological therapies using acetylcholinesterase inhibitors, such as pyridostigmine bromide (PYR), aiming to increase parasympathetic tone after MI. Here we hypothesized that the use of PYR before the MI might bring an additional positive effect to the autonomic function, and consequently, in the inflammatory response and cardiac function. Read More

Aging (Albany NY) 2019 Feb 21. Epub 2019 Feb 21.

Department of Cardiology, Zhengzhou University People's Hospital, Zhengzhou, Henan, China.

Stem cell-derived extracellular vesicles (EVs) have emerged as a promising therapy for myocardial infarction, but its effects remain incompletely understood. We aim to systematically review the efficacy of EVs on myocardial infarction in both small and large animals.On April 5, 2018, we searched the PubMed, Embase and Web of Science databases using variations of "myocardial infarction" and "extracellular vesicle". Read More

Heart 2019 Feb 21. Epub 2019 Feb 21.

Peter Munk Cardiac Centre and Women's College Hospital, University of Toronto, Toronto, Ontario, Canada.

Objective: To evaluate cardiovascular (CV) outcomes in outpatients with coronary artery disease (CAD) living alone compared with those living with others.

Methods: The prospeCtive observational LongitudinAl RegIstry oF patients with stable coronarY artery disease (CLARIFY) included outpatients with stable CAD. CLARIFY enrolled participants in 45 countries from November 2009 to July 2010, with 5 years of follow-up. Read More

J Vasc Surg 2019 Feb 18. Epub 2019 Feb 18.

Division of Vascular Surgery, Department of Surgery, Stanford University, Stanford, Calif.

Objective: Previous studies evaluating general anesthesia (GA) vs regional (epidural/spinal) anesthesia (RA) for infrainguinal bypass have produced conflicting results. The purpose of this study was to analyze the factors associated with contemporary use of RA and to determine whether it is associated with improved outcomes after infrainguinal bypass in patients with critical limb ischemia.

Methods: Using the Vascular Quality Initiative infrainguinal database, a retrospective review identified all critical limb ischemia patients who received an infrainguinal bypass from 2011 through 2016. Read More

Curr Probl Cardiol 2019 Jan 8. Epub 2019 Jan 8.

Randomized controlled trials comparing drug eluting stents (DES) with bare-metal stents (BMS) for saphenous vein graft (SVG) interventions have shown conflicting results. We conducted this meta-analysis to evaluate the cumulative evidence for long-term efficacy and safety of DES vs BMS in SVG lesions. A systematic search was conducted of Randomized controlled trials comparing DES vs BMS in patients undergoing percutaneous interventions for SVG lesions. Read More

Med Sci (Basel) 2019 Feb 20;7(2). Epub 2019 Feb 20.

Department of Radiology SUNY Downstate Medical Center/Health + Hospitals Kings County, Brooklyn, NY 11201, USA.

Rheumatoid arthritis (RA) patients have nearly twice the risk of cardiovascular disease (CVD) compared to the general population. We aimed to assess, in a predominantly Black population, the prevalence of traditional and RA-specific CVD risk factors and therapeutic patterns. Utilizing ICD codes, we identified 503 RA patients ≥18 years old who were seen from 2010 to 2017. Read More

Int J Mol Sci 2019 Feb 20;20(4). Epub 2019 Feb 20.

Division of Vascular Surgery, Department of Surgery, University of Maryland School of Medicine, 22 South Greene Street, Suite S10B00, Baltimore, MD 21201, USA.

Over eighty million people in the United States have cardiovascular disease that can affect the heart causing myocardial infarction; the carotid arteries causing stroke; and the lower extremities leading to amputation. The treatment for end-stage cardiovascular disease is surgical-either endovascular therapy with balloons and stents-or open reconstruction to reestablish blood flow. All interventions damage or destroy the protective inner lining of the blood vessel-the endothelium. Read More

J Clin Med 2019 Feb 20;8(2). Epub 2019 Feb 20.

Belvedere Elementary School, Aiken County Public School District, N. Augusta, SC 29841, USA.

Cardiovascular disease (CVD) is a major underlying cause of death, with high economic burden in most countries, including the United States. Lifestyle modifications and the use of antiplatelet therapy, such as aspirin, can contribute significantly to secondary prevention of CVD in adults. This study examined the prevalence and associated factors of aspirin use for the secondary prevention of angina pectoris, myocardial infarction (MI), and cerebrovascular disease (stroke) in a sample of American adults. Read More

Resuscitation 2019 Feb 18. Epub 2019 Feb 18.

Department of Cardiology and Cardiovascular Medicine, University Hospital of Tübingen, Germany. Electronic address:

Aims: Cangrelor has a potentially favorable pharmacodynamic profile in cardiogenic shock (CS). We aimed to evaluate the clinical course of CS patients undergoing percutaneous coronary intervention (PCI) treated with cangrelor.

Methods And Results: We retrospectively identified 136 CS patients treated with cangrelor. Read More

Cell Physiol Biochem 2019 18;52(1):40-56. Epub 2019 Feb 18.

Division of Cardiology, Department of Internal Medicine, Kyung Hee University Hospital, Hoegi-Dong, Republic of Korea.

Background/aims: Therapies using stem/progenitor cells have been experimentally and clinically investigated to regenerate damaged hearts. Substance-P (SP) induces bone marrow (BM) stem cell mobilization and suppresses inflammation in ischemic injuries. This study investigated the role of SP in BM stem cell mobilization and immune responses for tissue repair after ischemic-reperfusion injury (IRI), in comparison with that of granulocyte colony-stimulating factor (GCSF). Read More

Diabetes Metab Res Rev 2019 Feb 21:e3145. Epub 2019 Feb 21.

Department of Clinical Sciences, Malmö, Faculty of Medicine, Lund University, Clinical Research Center, Malmö, Sweden.

Background: Risk factors included in the CHA DS -VASc score, currently used for atrial fibrillation (AF), may predispose to cardiovascular events whether or not AF is present. Aim was to explore the predictive role of CHA DS -VASc score on cardiovascular outcomes in diabetic patients without AF.

Methods: We accessed individual data from 610 diabetic patients without AF at baseline included in the prospective cohort of the Malmö Diet and Cancer Study. Read More

Heart Vessels 2019 Feb 21. Epub 2019 Feb 21.

Department of Cancer Pathology, Faculty of Medicine, Hokkaido University, Sapporo, Japan.

Obstructive sleep apnea (OSA) is associated with coronary artery disease (CAD) and with an increased risk for myocardial infarction, stroke or death due to cardiovascular disease. Optical frequency-domain imaging (OFDI) is a useful modality for evaluating the characteristics of atherosclerotic plaque. The purpose of the study was to use OFDI to investigate the association of OSA with coronary plaque characteristics in patients undergoing percutaneous coronary intervention (PCI). Read More

PLoS One 2019 21;14(2):e0212230. Epub 2019 Feb 21.

School of Medicine and Public Health, The University of Newcastle, Callaghan, NSW, Australia.

Introduction: The prevalence of heart failure increases in the aging population and following myocardial infarction (MI), yet the extracellular matrix (ECM) remodeling underpinning the development of aging- and MI-associated cardiac fibrosis remains poorly understood. A link between inflammation and fibrosis in the heart has long been appreciated, but has mechanistically remained undefined. We investigated the expression of a novel protein, extracellular matrix protein 1 (ECM1) in the aging and infarcted heart. Read More

PLoS One 2019 21;14(2):e0199802. Epub 2019 Feb 21.

Department of Cardiology, First Hospital of Harbin City, Harbin, Heilongjiang Province, China.

Introduction: This study aimed to investigate the effect of aerobic exercise on the expression of neitrin-1,DCC receptor and myocardial fibrosis in rats with acute myocardial infarction.

Methods: Twenty-four rats were randomly divided into three groups: the sham group (n = 8), the acute myocardial infarction (AMI) model group (n = 8), and the aerobic exercise treatment after acute myocardial infarction group (ET) (n = 8). After 10 weeks, the serum levels of netrin-1, tumor necrosis factor alpha α (TNF-α), and interleukin 6 (IL-6) were measured. Read More

Med Care 2019 Feb 14. Epub 2019 Feb 14.

Department of Urology, Michigan Medicine, Ann Arbor, MI.

Importance: The benefits of public payment policy may extend to private populations through "spillover" effects. If cost-saving efforts in Medicare also reduce costs among commercially insured patients, Medicare payment systems could be a versatile policy tool in future reform efforts.

Objectives: To determine whether physicians who participated in a Medicare Accountable Care Organization (ACO) reduced spending among their commercial patients. Read More

Coron Artery Dis 2019 Feb 15. Epub 2019 Feb 15.

CHU Nancy, Département de Cardiologie.

Objective: The aim of this study was to describe the procedural characteristics, myocardial perfusion, and long-term outcomes in ST-elevation myocardial infarction patients with an ectatic infarct-related artery (IRA).

Patients And Methods: The retrospective analysis included 1270 consecutive ST-elevation myocardial infarction patients treated by primary percutaneous coronary intervention who were categorized according to the coronary anatomy of the IRA as follows: ectatic group (n=91) and control group (n=1179).

Results: Compared with the control group, patients in the ectatic group experienced lower Thombolysis in myocardial infarction grade 3 flow rate after percutaneous coronary intervention (64. Read More

Eur J Prev Cardiol 2019 Jan 30;26(2):160-170. Epub 2018 Nov 30.

1 Department of Cardiology, Guangdong Provincial Hospital of Chinese Medicine, China.

The roles of endothelial nitric oxide synthase gene polymorphisms in coronary artery disease have been intensively analyzed, with inconsistent results. Therefore, we performed this study to better assess the relationship between endothelial nitric oxide synthase genetic variations and the risk of coronary artery disease. Eligible studies were searched in PubMed, Medline, Embase, and Web of Science. Read More

Clin Cardiol 2019 Feb 20. Epub 2019 Feb 20.

FACT (French Alliance for Cardiovascular Trials), an F-CRIN network, Département Hospitalo-Universitaire FIRE, AP-HP, Hôpital Bichat, Université Paris-Diderot, INSERM U-1148, Paris, France.

In the setting of prior myocardial infarction, the oral antiplatelet ticagrelor added to aspirin reduced the risk of recurrent ischemic events, especially in those with diabetes mellitus. Patients with stable coronary disease and diabetes are also at elevated risk and might benefit from dual antiplatelet therapy. The Effect of Ticagrelor on Health Outcomes in diabEtes Mellitus patients Intervention Study (THEMIS, NCT01991795) is a Phase 3b randomized, double-blinded, placebo-controlled trial of ticagrelor versus placebo, on top of low dose aspirin. Read More

Am J Cardiovasc Drugs 2019 Feb 20. Epub 2019 Feb 20.

Division of Cardiology, Severance Cardiovascular Hospital, Yonsei University College of Medicine, Seoul, South Korea.

Introduction: Data concerning the clinical impact of combination therapy with β-blockers (BBs) + angiotensin-converting enzyme inhibitors (ACEIs) compared with BBs + angiotensin-receptor blockers (ARBs) in patients with acute myocardial infarction (AMI) after percutaneous coronary intervention (PCI) with drug-eluting stents (DES) are limited.

Objective: We compared the clinical outcomes at 2 years between these two combination therapies.

Methods: We enrolled 23,978 patients with AMI who underwent successful PCI with DES between January 2005 and June 2015 from the Korea AMI Registry (KAMIR) and divided them into the two groups: BB + ACEI (n = 17,310) and BB + ARB (n = 6668). Read More

Neurotherapeutics 2019 Feb 20. Epub 2019 Feb 20.

Department of Neurosurgery, China Medical University Hospital, 2 Hsueh-Shuh Road, Taichung, 40407, Taiwan.

Debates regarding the most beneficial medical or surgical procedures for patients with spontaneous intracerebral hemorrhage (sICH) are still ongoing. We aimed to evaluate the risk of subsequent vascular disease and mortality in patients with sICH treated with and without surgical intervention, in a large-scale Asian population. Patients hospitalized within 2000 to 2013 who were newly diagnosed with sICH were identified using the National Health Insurance Research Database of Taiwan. Read More

Emerg (Tehran) 2018 15;6(1):e61. Epub 2018 Dec 15.

Physiology Research Center, Faculty of Medicine, Iran University of Medical Sciences, Tehran, Iran.

Introduction: There is still no consensus on the value of Manchester Acute Coronary Syndromes (MACS) decision rule in detecting acute coronary syndrome (ACS). Therefore, the purpose of the present systematic review and meta-analyzes is to summarize the clinical evidence in the evaluation of the value of MACS in the diagnosis of ACS.

Methods: A literature search was performed on the Medline, Embase, Scopus, and Web of Science databases. Read More

Avicenna J Phytomed 2019 Jan-Feb;9(1):1-9

Department of Internal Medicine, Mashhad University of Medical Sciences, Mashhad, Iran.

Objective: Inflammation along with oxidative stress has an important role in the pathophysiology of unstable angina which leads to acute myocardial infarction, arrhythmias and eventually heart failure. Curcumin has anti-inflammatory and anti-oxidant effects and thereby, it may reduce cardiovascular complications. This randomized controlled trial aimed to investigate the effects of curcumin on the prevention of atrial and ventricular arrhythmias and heart failure in patients with unstable angina. Read More

Cureus 2018 Dec 11;10(12):e3711. Epub 2018 Dec 11.

Internal Medicine, University of Kentucky, Lexington, USA.

Isolated aortitis is a rare entity and was recently included in the 2012 Revised International Chapel Hill Consensus Conference Nomenclature of Vasculitides under the single organ vasculitis group. Isolated aortitis represents a challenging situation due to the lack of reliable diagnostic methodology. Here, we describe the case of a 46-year-old woman who presented with severe upper back pain. Read More

J Gastrointest Oncol 2019 Feb;10(1):30-36

Division of Cardiology, Department of Medicine, Albany Medical Center, Albany, NY, USA.

Background: Primary right-sided colon cancer (RCC) is associated with a higher mortality than left-sided colon cancer (LCC), but the etiology of this phenomenon remains unclear. We sought to study whether cancer laterality is associated with the prevalence of clinical coronary artery disease, calcific atherosclerosis as measured by computed tomography (CT), and cardiovascular risk factors.

Methods: We conducted a single center retrospective study of 546 participants who had previously been diagnosed with colon cancer between January 2005 and December 2014. Read More

Methodist Debakey Cardiovasc J 2018 Oct-Dec;14(4):281-288

HOUSTON METHODIST HOSPITAL, HOUSTON, TEXAS.

Pharmacological options for treatment of type 2 diabetes (T2D) have advanced rapidly during the last 10 years, allowing clinicians to target different pathophysiological defects in this disease. There are currently 12 different classes of drugs available to treat T2D. The most exciting development is the demonstration of cardiovascular (CV) benefits from two of these new classes, the glucagon-like peptide-1 receptor agonists (GLP-1 RA) and selective sodium glucose transporter 2 (SGLT2) inhibitors. Read More

Methodist Debakey Cardiovasc J 2018 Oct-Dec;14(4):266-272

HOUSTON METHODIST HOSPITAL, HOUSTON, TEXAS.

Coronary artery disease (CAD) is the leading cause of morbidity and mortality in patients with diabetes mellitus. Patients with diabetes have a higher prevalence of CAD and a larger magnitude of ischemia, and they are more likely to have silent myocardial ischemia and myocardial infarction. However, recent large cohort studies demonstrate that diabetic patients are not a homogenous group with similar high risk for cardiac events. Read More

Methodist Debakey Cardiovasc J 2018 Oct-Dec;14(4):251-256

HOUSTON METHODIST HOSPITAL, HOUSTON, TEXAS.

Cardiovascular autonomic neuropathy (CAN) is a severely debilitating yet underdiagnosed condition in patients with diabetes. The prevalence can range from 2.5% (based on the primary prevention cohort in the Diabetes Control and Complications Trial) to as high as 90% of patients with type 1 diabetes. Read More

Am J Transl Res 2019 15;11(1):351-360. Epub 2019 Jan 15.

Department of Cardiology, The First Affiliated Hospital of Nanjing Medical University Nanjing, P. R. China.

Sodium tanshinone IIA sulfonate (STS), a water-soluble derivative of tanshinone IIA, has been used in traditional Chinese medicine for many years. Many experiments have demonstrated that STS has anti-inflammatory, anti-apoptosis and angiogenesis effects. However, it is unclear whether STS has the same beneficial effects on myocardial infarction . Read More

Am J Transl Res 2019 15;11(1):67-86. Epub 2019 Jan 15.

Division of Cardiology, Department of Internal Medicine, Kaohsiung Chang Gung Memorial Hospital and Chang Gung University College of Medicine Kaohsiung 83301, Taiwan.

We tested the hypothesis that adipose-derived fresh stromal vascular fraction (SVF) is non-inferior to conventional adipose-derived mesenchymal stem cell (ADMSC) therapy for improving left-ventricular ejection fraction (LVEF) in rat after acute myocardial infarction (AMI). Male-adult SD rats (n = 48) were categorized into group 1 (sham control), AMI, AMI + ADMSCs (1.2 × 10) cells] and AMI + SVF (1. Read More

Diabetes Metab Syndr Obes 2019 1;12:209-215. Epub 2019 Feb 1.

Stanford Center for Clinical Research, Department of Medicine, Stanford University School of Medicine, Palo Alto, CA, USA.

Canagliflozin is a sodium glucose-cotransporter (SGLT) receptor inhibitor approved for the treatment of type 2 diabetes mellitus (T2DM). This article reviews the mechanism of action of SGLT-2 receptor inhibitors and the efficacy of canagliflozin as an antidiabetic agent, its cardiovascular and renal benefits, and safety profile. During the development of canagliflozin, Phase II trials showed an improvement in cardiac and renal biomarkers such as blood pressure, body weight, and albuminuria. Read More

Ann Transplant 2019 Feb 21;24:100-107. Epub 2019 Feb 21.

Kidney Transplant Program, St. Michael's Hospital, Toronto, ON, Canada.

BACKGROUND Preventing major adverse cardiovascular events (MACE) after kidney transplantation motivates pre-transplant cardiac evaluation that includes two-dimensional transthoracic echocardiography (TTE). The relationship of relative wall thickness (RWT) to left ventricular mass index (LVMI) in predicting post-transplant MACE is unclear. MATERIAL AND METHODS In this multi-ethnic Canadian single-center cohort study, we identified 1063 adults undergoing pre-transplant TTE within 1 year pre-transplant and with minimum 6 months of post-kidney transplant follow-up for MACE, defined as a composite of coronary revascularization, myocardial infarction, stroke, and cardiac death. Read More

BMJ Open 2019 Feb 20;9(2):e023337. Epub 2019 Feb 20.

Research Institute for Primary Care and Health Sciences, Keele University, Newcastle, UK.

Objective: The primary objective was to determine the incidence of bleeding events post acute coronary syndrome (ACS) following hospital discharge. The secondary objective was to determine the prognostic impact of bleeding on mortality, major adverse cardiovascular events (MACE), myocardial re-infarction and rehospitalisation in the postdischarge setting.

Design: A narrative systematic review. Read More

BMJ 2019 Feb 20;364:l298. Epub 2019 Feb 20.

Nuffield Department of Orthopaedics, Rheumatology and Musculoskeletal Sciences, University of Oxford, Botnar Research Centre, Oxford OX3 7LD, UK.

Objectives: To provide accurate risk estimates of serious adverse events after elective shoulder replacement surgery for arthritis, including age and sex specific estimates of the lifetime risk of revision surgery.

Design: Population based cohort study.

Setting: Hospital episode statistics for NHS England, including civil registration mortality data. Read More

Hum Gene Ther 2019 Feb 21. Epub 2019 Feb 21.

Fundacion Centro Nacional de Investigaciones Cardiovasculares Carlos III, 38799 , Melchor Fernandez Almagro 3 , Madrid, Spain , 28029 ;

Microvascular dysfunction and resulting tissue hypoxia is a major contributor to the pathogenesis and evolution of cardiovascular diseases (CVD). Diverse gene and cell therapies have been proposed to preserve the microvasculature or boost angiogenesis in CVD with moderate benefit. In this study, we tested in vivo the impact of sequential delivery by bone marrow cells of the pro-angiogenic factors vascular endothelial growth factor (VEGFA) and sphingosine-1-phosphate (S1P) in a myocardial infarction model. Read More

Circulation 2019 Feb 21. Epub 2019 Feb 21.

TIMI Study Group, Brigham and Women's Hospital, Boston, MA.

Background: Glucagon-like peptide 1 receptor agonists (GLP1-RA) and sodium-glucose contransporter-2 inhibitors (SGLT2i) have emerged as two new classes of antihyperglycemic agents that also reduce cardiovascular risk. The relative benefits in patients with and without established atherosclerotic cardiovascular disease (ASCVD) for different outcomes with these classes of drugs remain undefined.

Methods: We performed a systematic review and trial-level meta-analysis of GLP1-RA and SGLT2i cardiovascular outcomes trials using the PubMed and EMBASE databases. Read More

PLoS One 2019 20;14(2):e0212398. Epub 2019 Feb 20.

Department of Epidemiology of Lazio Regional Health Service, Rome, Italy.

Background: The relationship between guideline adherence and outcomes in patients with acute myocardial infarction (AMI) has been widely investigated considering the emergency, acute, post-acute phases separately, but the effectiveness of the whole care process is not known.

Aim: The study aim was to evaluate the effect of the multicomponent continuum of care on 1-year survival after AMI.

Methods: We conducted a cohort study selecting all incident cases of AMI from health information systems during 2011-2014 in the Lazio region. Read More

ACS Appl Mater Interfaces 2019 Feb 20. Epub 2019 Feb 20.

Atherosclerosis is a major cause of sudden death and myocardial infarction, instigated by unstable plaques. Thus, the early detection of unstable plaques and corresponding treatment can improve the prognosis and reduce mortality. In this study, we describe a protocol for the preparation of nanoparticles (NPs) combined with the phase transitional material perfluorohexane (PFH) and with dextran sulfate (DS) targeting class A scavenger receptors (SR-A) for the diagnosis and treatment of atherosclerotic vulnerable plaques. Read More