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    A single injection of protein-loaded coacervate-gel significantly improves cardiac function post infarction.
    Biomaterials 2017 Feb 17;125:65-80. Epub 2017 Feb 17.
    Department of Bioengineering, University of Pittsburgh, Pittsburgh, PA 15261, USA; Department of Chemical and Petroleum Engineering, University of Pittsburgh, Pittsburgh, PA 15261, USA; Department of Surgery, University of Pittsburgh, Pittsburgh, PA 15261, USA; Department of Mechanical Engineering and Materials Science, University of Pittsburgh, Pittsburgh, PA 15261, USA; McGowan Institute for Regenerative Medicine, University of Pittsburgh, Pittsburgh, PA 15219, USA; Vascular Medicine Institute, University of Pittsburgh, Pittsburgh, PA 15261, USA; Clinical and Translational Science Institute, University of Pittsburgh, Pittsburgh, PA 15260, USA. Electronic address:
    After myocardial infarction (MI), the heart undergoes fibrotic pathological remodeling instead of repair and regeneration. With multiple pathologies developing after MI, treatment using several proteins is expected to address this range of pathologies more effectively than a single-agent therapy. A factorial design of experiments study guided us to combine three complementary factors in one injection: tissue inhibitor of metalloproteinases-3 (TIMP-3) was embedded in a fibrin gel for signaling in the initial phase of the treatment, while basic fibroblast growth factor (FGF-2) and stromal cell-derived factor 1-alpha (SDF-1α) were embedded in heparin-based coacervates for sustained release and distributed within the same fibrin gel to exert their effects over a longer period. Read More

    ZYZ-772 Prevents Cardiomyocyte Injury by Suppressing Nox4-Derived ROS Production and Apoptosis.
    Molecules 2017 Feb 21;22(2). Epub 2017 Feb 21.
    Department of Pharmacology, School of Pharmacy, Fudan University, Shanghai 201203, China.
    Nox-dependent signaling plays critical roles in the development of heart failure, cardiac hypertrophy, and myocardial infarction. NADPH oxidase 4 (Nox4) as a major source of oxidative stress in the heart offers a new therapeutic target in cardiovascular disease. In the present work, a novel flavonoid was isolated from Zanthoxylum bungeanum. Read More

    Antithrombotic therapy for patients with STEMI undergoing primary PCI.
    Nat Rev Cardiol 2017 Feb 23. Epub 2017 Feb 23.
    University of Florida College of Medicine-Jacksonville, Division of Cardiology-ACC Building 5th floor, 655 West 8th Street, Jacksonville, Florida 32209, USA.
    Antithrombotic therapy, including antiplatelet and anticoagulant agents, is the cornerstone of pharmacological treatment to optimize clinical outcomes in patients with ST-segment elevation myocardial infarction (STEMI) undergoing primary percutaneous coronary intervention (PPCI). Intravenous anticoagulant drugs available for PPCI include the indirect thrombin inhibitors unfractionated heparin and low-molecular-weight heparin, and the direct thrombin inhibitor bivalirudin. Intravenous antiplatelet drugs mainly include glycoprotein IIb/IIIa inhibitors and the P2Y12-receptor inhibitor cangrelor. Read More

    Association between N-terminal proB-type Natriuretic Peptide and Depressive Symptoms in Patients with Acute Myocardial Infarction.
    Chin Med J (Engl) 2017 5th Mar;130(5):542-548
    Department of Health Statistics, School of Public Health, Shanxi Medical University, Taiyuan, Shanxi 030001, China.
    Background: While depression and certain cardiac biomarkers are associated with acute myocardial infarction (AMI), the relationship between them remains largely unexplored. We examined the association between depressive symptoms and biomarkers in patients with AMI.

    Methods: We performed a cross-sectional study using data from 103 patients with AMI between March 2013 and September 2014. Read More

    Mid-diastolic left ventricular volume and mass: Normal values for coronary computed tomography angiography.
    J Cardiovasc Comput Tomogr 2017 Feb 10. Epub 2017 Feb 10.
    Department of Medicine (Cardiology), University of Ottawa Heart Institute, Ontario, Canada; Department of Radiology, University of Ottawa Faculty of Medicine, Ontario, Canada. Electronic address:
    Background: The adoption of prospectively ECG-triggered acquisition coronary computed tomography angiography (CTA) has resulted in the inability to measure left ventricle (LV) end-diastolic volume and LV ejection fraction. However other prognostic measures such as LV mass and LV mid-diastolic volume (LVMDV) can still be assessed. The objective of this study is to establish normal reference values for LVMDV and LV mass. Read More

    Optimized energy of spectral CT for infarct imaging: Experimental validation with human validation.
    J Cardiovasc Comput Tomogr 2017 Feb 11. Epub 2017 Feb 11.
    Radiology and Imaging Sciences - National Institutes of Health Clinical Center, Bethesda, MD, USA. Electronic address:
    Objectives: Late contrast enhancement visualizes myocardial infarction, but the contrast to noise ratio (CNR) is low using conventional CT. The aim of this study was to determine if spectral CT can improve imaging of myocardial infarction.

    Materials And Methods: A canine model of myocardial infarction was produced in 8 animals (90-min occlusion, reperfusion). Read More

    Effect of cerebrolysin on oxidative stress-induced apoptosis in an experimental rat model of myocardial ischemia.
    Physiol Int 2016 Sep;103(3):310-320
    2 Department of Medical Biochemistry, Faculty of Medicine, Mansoura University , Mansoura, Egypt.
    Apoptosis plays a role in the process of tissue damage after myocardial infarction (MI). This study was designed to investigate the possible effect of cerebrolysin against apoptosis triggered by oxidative cell stress in myocardial ischemia induced by isoproterenol in rat. Rats were pretreated with cerebrolysin 5 mL/kg intraperitoneally for 7 days and intoxicated with isoproterenol (ISO, 85 mg/kg, sc) on the last 2 days. Read More

    Optimal Environmental Stiffness for Stem Cell Mediated Ischemic Myocardium Repair.
    Methods Mol Biol 2017 ;1553:293-304
    Department of Pathology and Laboratory Medicine, University of Cincinnati Medical Center, Cincinnati, OH, 45267, USA.
    Cardiovascular diseases related to myocardial infarction (MI) contribute significantly to morbidity and mortality worldwide. The loss of cardiomyocytes during MI is a key factor in the impairment of cardiac-pump functions. Employing cell transplantation has shown great potential as a therapeutic approach in regenerating ischemic myocardium. Read More

    Therapeutic Application of Adult Stem Cells in the Heart.
    Methods Mol Biol 2017 ;1553:249-264
    Division of Metabolic and Cardiovascular Sciences, Burnett School of Biomedical Sciences, University of Central Florida, 4110 Libra Dr., Orlando, FL, USA.
    Cell therapies have been explored as a potential treatment avenue to treat heart diseases, such as myocardial infarction, doxorubicin-induced cardiomyopathy, and heart failure. Embryonic and adult stem cells (ASCs) have been examined in animal and clinical settings. Unlike embryonic and induced pluripotent stem cells, ASCs do not pose a threat to form teratomas, nor do they have immune system concerns, making them ideal for therapeutic use in humans. Read More

    Echocardiography-Guided Intramyocardial Injection Method in a Murine Model.
    Methods Mol Biol 2017 ;1553:217-225
    Division of Cardiac Surgery, University of Ottawa Heart Institute, 40 Ruskin Street, Ottawa, ON, K1Y 4W7, Canada.
    Cardiac regenerative therapy has received attention as a potentially revolutionary approach for treating the damaged heart. The mouse model of myocardial infarction (MI) remains one of the most common tools for the evaluation of such new therapies. Typically, intramyocardial administration of cells or biomaterials in mice is performed by an open-chest surgical procedure, but less invasive delivery methods are becoming available. Read More

    Platelet turnover predicts outcome after coronary intervention.
    Thromb Haemost 2017 Feb 23. Epub 2017 Feb 23.
    Matthias K. Freynhofer, MD, 3rd Department of Medicine, Cardiology, Wilhelminen Hospital, Montleartstraße 37, A-1160, Vienna, Austria, Tel.: +43 1 49150 2301, Fax: +43 1 49150 2309, E-mail:
    Elevated platelet turnover contributes to high platelet reactivity. High platelet reactivity after percutaneous coronary intervention (PCI) is associated with major adverse cardiovascular events (MACE). The purpose of this study was to determine the prognostic value of platelet turnover and function with regard to MACE after PCI with stent implantation. Read More

    Surgical treatment of left ventricular wall rupture, regarded as a consequence of Takotsubo cardiomyopathy.
    SAGE Open Med Case Rep 2017 18;5:2050313X16689210. Epub 2017 Jan 18.
    Scientific Research Institute of Heart Surgery and Organ Transplantation, Bishkek, Kyrgyzstan.
    Objective: We present the case of possible reverse type of TCM in a female patient presented with progressive left ventricular dysfunction and its rupture in pericardium.

    Methods: The detailed history, physical examination, laboratory tests, electrocardiography, serial echocardiography, coronary angiography with left ventriculography were performed to diagnose possible Takotsubo cardiomyopathy in 63-year old woman admitted to our center with complaints of dyspnea, lightheadedness, weakness and signs of hypotension and history of inferior myocardial infarction, acute left ventricular aneurysm, and effusive pericarditis and pleuritis, developed after emotional stress 5 months ago.

    Results: Clinical evaluation revealed unremarkable laboratory tests, normal troponin values, signs of old inferior myocardial infarction on electrocardiogram, and left ventricular (LV) dilatation and dysfunction, akinesia of LV infero-lateral wall with thinning and its rupture and blood shunting in pericardium. Read More

    Outcomes of coronary artery bypass grafting versus percutaneous coronary intervention with second-generation drug-eluting stents for patients with multivessel and unprotected left main coronary artery disease.
    SAGE Open Med 2017 18;5:2050312116687707. Epub 2017 Jan 18.
    Saint George's Medical School, University of Nicosia Medical School, Nicosia, Cyprus.
    Objectives: To compare the efficacy and safety of percutaneous coronary intervention using second-generation drug-eluting stents with those of coronary artery bypass grafting among patients with multivessel disease and/or unprotected left main coronary artery disease in terms of mortality, myocardial infarction, repeat revascularization, and angina.

    Background: Although coronary artery disease is a leading cause of death in the Western world and in many developing countries, its optimal treatment is still a matter of controversy. Several studies have examined the clinical safety and efficacy of percutaneous coronary intervention using first-generation drug-eluting stents over coronary artery bypass grafting in patients with multivessel disease and/or unprotected left main coronary artery disease. Read More

    Transarterial embolization of a hyperfunctioning aldosteronoma in a patient with bilateral adrenal nodules.
    Radiol Case Rep 2017 Mar 29;12(1):87-91. Epub 2016 Nov 29.
    Department of Vascular and Interventional Radiology, University of Miami Miller School of Medicine, 1611 NW 12th Ave, Miami, FL 33136-1005, USA.
    Primary hyperaldosteronism often results in resistant hypertension and hypokalemia, which may lead to cardiovascular and cerebrovascular complications. Although surgery is first line treatment for unilateral functioning aldosteronomas, minimally invasive therapies may be first line for certain patients such as those who cannot tolerate surgery. We present a case of transarterial embolization (TAE) of an aldosteronoma. Read More

    Bone scintigraphy of severe hypercalcemia following simvastatin induced rhabdomyolysis.
    Clin Cases Miner Bone Metab 2016 Sep-Dec;13(3):257-261. Epub 2017 Feb 10.
    Rutgers Robert Wood Johnson Medical School, New Brunswick, NJ, USA.
    Simvastatin induced rhabdomyolysis with renal failure is a well reported clinical entity with hyperkalemia recognized as a life threatening risk. The risk of delayed hypercalcemia during the recovery of renal function is not well appreciated as this varies in severity and can be caused by multiple mechanisms. We present a patient with high dose simvastatin induced rhabdomyolysis leading to late onset of severe hypercalcemia due to calcium phosphate deposition in muscles diagnosed by distinctive bone scintigraphy. Read More

    Amnesia Associated with Bilateral Hippocampal and Bilateral Basal Ganglia Lesions in Anoxia with Stimulant Use.
    Front Neurol 2017 8;8:27. Epub 2017 Feb 8.
    Department of Behavioral Medicine and Psychiatry, West Virginia University School of Medicine , Morgantown, WV , USA.
    We report a case of a 55-year-old man with ischemic lesions of the bilateral hippocampus and bilateral basal ganglia following a myocardial infarction during an episode of multiple drug use with subsequent anoxia requiring resuscitation. He presented for a neuropsychological evaluation with an anterograde amnesia for both explicit and procedural memory. There are two main points to this case, the unique aspects of the bilateral multifocal lesions and the functional, cognitive impact of these lesions. Read More

    Physical and psychological characteristics of the community-dwelling elderly with heart disease.
    Nihon Koshu Eisei Zasshi 2017 ;64(1):3-13
    Tokyo Metropolitan Geriatric Hospital and Institute of Gerontology.
    Objectives Although the survival rates of patients with heart diseases, such as myocardial infarction and heart failure, have increased, the incidence of heart disease in elderly individuals has also increased. We compared characteristics of the community-dwelling elderly with heart diseases (heart disease group) and without heart diseases (non-heart disease group).Methods A total of 758 elderly individuals participated in our survey ("Otassha-kensin") in 2014. Read More

    Barriers Associated With Door-to-Balloon Delay in Contemporary Japanese Practice.
    Circ J 2017 Feb 23. Epub 2017 Feb 23.
    Department of Cardiology, Keio University School of Medicine.
    Background: Door-to-balloon (DTB) time ≤90 min is an important quality indicator in the management of ST-elevation myocardial infarction (STEMI), but a considerable number of patients still do not meet this goal, particularly in countries outside the USA and Europe.Methods and Results:We analyzed 2,428 STEMI patients who underwent primary PCI ≤12 h of symptom onset who were registered in an ongoing prospective multicenter database (JCD-KiCS registry), between 2008 and 2013. We analyzed both the time trend in DTB time within this cohort in the registry, and independent predictors of delayed DTB time >90 min. Read More

    Ten-Year Temporal Trends in Medical Complications After Acute Intracerebral Hemorrhage in the United States.
    Stroke 2017 Feb 22. Epub 2017 Feb 22.
    From the Department of Neurology, University of Miami Miller School of Medicine, FL.
    Background And Purpose: Data on medical complications after intracerebral hemorrhage (ICH) are sparse. We assessed trends in the prevalence of urinary tract infection, pneumonia, sepsis, deep venous thrombosis (DVT), pulmonary embolism, acute renal failure (ARF), and acute myocardial infarction after ICH in the United States.

    Methods: A total of 575 211 adult ICH cases were identified from the 2004 to 2013 Nationwide Inpatient Sample. Read More

    Sex Differences in Inflammatory Markers and Health Status Among Young Adults With Acute Myocardial Infarction: Results From the VIRGO (Variation in Recovery: Role of Gender on Outcomes of Young Acute Myocardial Infarction Patients) Study.
    Circ Cardiovasc Qual Outcomes 2017 Feb 22;10(2):e003470. Epub 2017 Feb 22.
    From the Center for Outcomes Research and Evaluation, Yale-New Haven Hospital, CT (Y.L., S.Z., R.P.D., E.S.S., H.M.K.); Section of Cardiovascular Medicine, Department of Internal Medicine (Y.L., S.Z., R.P.D., E.S.S., H.M.K.), Section of General Internal Medicine, Department of Internal Medicine (M.G., N.P.L.), Robert Wood Johnson Foundation Clinical Scholars Program, Department of Internal Medicine (H.M.K.), and Department of Emergency Medicine (R.P.D., G.D.), Yale School of Medicine, New Haven, CT; Department of Chronic Disease Epidemiology (J.H.L.) and Department of Health Policy and Management (H.M.K.), Yale School of Public Health, New Haven, CT; University of Missouri-Kansas City (J.A.S.); Saint Luke's Mid America Heart Institute, Kansas City, MO (J.A.S.); and Center for Cardiovascular Disease Prevention, Brigham and Women's Hospital, Harvard Medical School, Boston, MA (P.M.R.).
    Background: Young women (≤55 years of age) with acute myocardial infarction (AMI) have higher mortality risk than similarly aged men. Elevated inflammatory markers are associated with an increased risk of cardiovascular outcomes after AMI, but little is known about whether young women have higher inflammatory levels after AMI compared with young men.

    Methods And Results: We assessed sex differences in post-AMI inflammatory markers and whether such differences account for sex differences in 12-month health status, using data from 2219 adults with AMI, 18 to 55 years of age, in the United States. Read More

    Young Women With Acute Myocardial Infarction: Current Perspectives.
    Circ Cardiovasc Qual Outcomes 2017 Feb 22;10(2). Epub 2017 Feb 22.
    From the Center for Outcomes Research and Evaluation (CORE), New Haven, CT (R.P.D., E.S.S., H.M.K.); Department of Emergency Medicine (R.P.D., B.S., G.D.) and Section of Cardiovascular Medicine (C.S., E.S.S., H.M.K.), Yale University School of Medicine, New Haven, CT; Section of Cardiovascular Medicine and the Robert Wood Johnson Foundation, New Haven, CT (H.M.K.); and Department of Health Policy and Management, Yale School of Public Health, New Haven, CT (H.M.K.).
    In recent years, there has been growing public awareness and increasing attention to young women with acute myocardial infarction (AMI), who represent an extreme phenotype. Young women presenting with AMI may develop coronary disease by different mechanisms and often have worse recoveries, with higher risk for morbidity and mortality compared with similarly aged men. The purpose of this cardiovascular perspective piece is to review recent studies of AMI in young women. Read More

    Myocardial Infarction Risk after Discontinuation of Thienopyridine Therapy in the Randomized DAPT Study.
    Circulation 2017 Feb 22. Epub 2017 Feb 22.
    Baim Institute for Clinical Research, Boston, MA & Brigham and Women's Hospital, Boston, MA
    Background -Thienopyridine plus aspirin beyond one year after coronary stenting (PCI) reduces myocardial infarction (MI) risk and increases bleeding risk compared with aspirin alone. The hazard associated with late thienopyridine discontinuation and risk factors for MI after discontinuation are poorly defined. Methods -In the Dual Antiplatelet Therapy (DAPT) Study, after PCI and 12 months of thienopyridine (clopidogrel or prasugrel) plus aspirin, eligible patients remained on aspirin and were randomized to continued thienopyridine vs. Read More

    A review of enhanced paramedic roles during and after hospital handover of stroke, myocardial infarction and trauma patients.
    BMC Emerg Med 2017 Feb 23;17(1). Epub 2017 Feb 23.
    Institute of Neuroscience (Stroke Research Group), Newcastle University, Newcastle upon Tyne, United Kingdom.
    Background: Ambulance paramedics play a critical role expediting patient access to emergency treatments. Standardised handover communication frameworks have led to improvements in accuracy and speed of information transfer but their impact upon time-critical scenarios is unclear. Patient outcomes might be improved by paramedics staying for a limited time after handover to assist with shared patient care. Read More

    Emergency Percutaneous Coronary Intervention Through the Left Radial Artery is Associated with Less Vascular Complications than Emergency Percutaneous Coronary Intervention Through the Femoral Artery.
    Clinics (Sao Paulo) 2017 Jan 1;72(1):1-4. Epub 2017 Jan 1.
    The First Hospital of Hebei Medical University, Department of Cardiology, China.
    Objective:: To compare the advantages and disadvantages of emergency percutaneous coronary intervention through the left radial artery with those of emergency percutaneous coronary intervention through the femoral artery.

    Methods:: A total of 206 patients with acute myocardial infarction who required emergency percutaneous coronary intervention and were admitted to our hospital between January 2011 and August 2013 were divided into the following two groups: a group that underwent percutaneous coronary intervention through the left radial artery and a group that underwent percutaneous coronary intervention through the femoral artery. The times required for angiographic catheter and guiding catheter placement, the success rate of the procedure and the incidence of vascular complications in the two groups were observed. Read More

    Homocysteine and all-cause mortality in hypertensive adults without pre-existing cardiovascular conditions: Effect modification by MTHFR C677T polymorphism.
    Medicine (Baltimore) 2017 Feb;96(8):e5862
    aDepartment of Cardiology, Peking University First Hospital, Beijing bNational Clinical Research Study Center for Kidney Disease; State Key Laboratory for Organ Failure Research; Renal Division, Nanfang Hospital, Southern Medical University, Guangzhou cInstitute for Biomedicine, Anhui Medical University dDepartment of Neurology, First Affiliated Hospital of Anhui Medical University, Hefei eDepartment of Cardiology, the Second Affiliated Hospital of Nanchang University, Jiangxi fDepartment of Neurology, First People's Hospital, Lianyungang gDepartment of Neurology, Guangdong Provincial Hospital of Chinese Medicine, Guangzhou hDepartment of Cardiology, Beijing Anzhen Hospital, Capital Medical University, Beijing iSchool of Health Administration, Anhui Medical University, Hefei jDepartment of Cardiology, Chinese People's Liberation Army General Hospital, Beijing kDepartment of Cardiology, The First Affiliated Hospital of Harbin Medical University, Harbin lDepartment of Cardiology, Peking University People's Hospital mDepartment of Pharmacy, Peking University First Hospital, Beijing, China.
    Background: Previous studies support an association between elevated total homocysteine (tHcy) levels and increased all-cause mortality. However, few prospective studies have examined this association in hypertensive patients, and/or tested any effect modification by the methylene tetrahydrofolate reductase (MTHFR) C677T genotype.

    Methods: This was a post hoc analysis of the China Stroke Primary Prevention Trial. Read More

    Acute myocardial infarction and antiphospholipid antibody syndrome: a systematic review.
    Coron Artery Dis 2017 Feb 20. Epub 2017 Feb 20.
    aInternal Medicine Resident, Reading Health System, Reading bDepartment of Cardiology cDepartment of Medicine, Sidney Kimmel Medical College, Thomas Jefferson University, Philadelphia, Pennsylvania.
    Background: Antiphospholipid antibody syndrome (APS) is a disorder associated with both arterial and venous thromboembolic disease, including acute myocardial infarction (AMI). Given that management with anticoagulants is critical and differs from usual AMI care, identification of key discriminators of patients with AMI with APS is important.

    Methods: We performed an English-language systematic review of the literature of cases and case series of patients with AMI and APS from inception until 20 March 2016, collecting demographics, investigations, and outcomes. Read More

    Endocr Pract 2017 Feb 22. Epub 2017 Feb 22.
    Target Health Inc, New York 10016, USA.
    Objective: Testosterone replacement therapy is indicated for male hypogonadism. This study aimed to evaluate the efficacy and safety of Testosterone gel 2% (Tgel) over 90-days.

    Methods: This phase 3, open-label, non-comparator study was conducted in adult hypogonadal men (two consecutive fasting serum testosterone values <300 ng/dL and >86% subjects with symptoms consistent with testosterone deficiency). Read More

    Targeted inhibition of Focal Adhesion Kinase Attenuates Cardiac Fibrosis and Preserves Heart Function in Adverse Cardiac Remodeling.
    Sci Rep 2017 Feb 22;7:43146. Epub 2017 Feb 22.
    Department of Cardiovascular Surgery, State Key Laboratory of Cardiovascular Disease, Fuwai Hospital, National Center for Cardiovascular Diseases, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing, China.
    Cardiac fibrosis in post-myocardial infarction (MI), seen in both infarcted and non-infarcted myocardium, is beneficial to the recovery of heart function. But progressively pathological fibrosis impairs ventricular function and leads to poor prognosis. FAK has recently received attention as a potential mediator of fibrosis, our previous study reported that pharmacological inhibition of FAK can attenuate cardiac fibrosis in post MI models. Read More

    Differences in outcomes in patients with stable coronary artery disease managed by cardiologists versus non-cardiologists: the international prospective CLARIFY registry.
    Pol Arch Med Wewn 2017 Jan 20. Epub 2017 Jan 20.
    INTRODUCTION    Clinical outcomes of patients with stable coronary artery disease (SCAD) may differ between those primarily managed by cardiologists versus non-cardiologists.  OBJECTIVES    Our main objective was to analyze the clinical outcomes of outpatients with SCAD in relation to the specialty of the managing physicians.  PATIENTS AND METHODS    We studied 32,468 outpatients with SCAD included in the CLARIFY registry, with up to 4 years follow-up data. Read More

    Impact of right ventricular function on outcome of severe aortic stenosis patients undergoing transcatheter aortic valve replacement.
    Am Heart J 2017 Feb 29;184:141-147. Epub 2016 Oct 29.
    Section of Interventional Cardiology, MedStar Washington Hospital Center, Washington, DC. Electronic address:
    Background: Right ventricular (RV) dysfunction was shown to be associated with adverse outcomes in a variety of cardiac patients and is considered a risk factor for adverse outcome according to the updated Valve Academic Research Consortium criteria.

    Objective: Our goal was to assess the impact of RV function at baseline on 1-year mortality among patients with severe aortic stenosis (AS) undergoing transcatheter aortic valve replacement (TAVR).

    Methods: All patients with severe AS treated with TAVR from May 2007 to March 2015 at our center were included in the present study, and baseline and procedural characteristics were recorded for each patient. Read More

    An age- and sex-specific gene expression score is associated with revascularization and coronary artery disease: Insights from the Prospective Multicenter Imaging Study for Evaluation of Chest Pain (PROMISE) trial.
    Am Heart J 2017 Feb 15;184:133-140. Epub 2016 Nov 15.
    Department of Medicine, Duke University School of Medicine, Durham, NC; Duke Clinical Research Institute, Duke University School of Medicine, Durham, NC.
    Background: Identifying predictors of coronary artery disease (CAD)-related procedures and events remains a priority.

    Methods: We measured an age- and sex-specific gene expression score (ASGES) previously validated to detect obstructive CAD (oCAD) in symptomatic nondiabetic patients in the PROMISE trial. The outcomes were oCAD (≥70% stenosis in ≥1 vessel or ≥50% left main stenosis on CT angiography [CTA]) and a composite endpoint of death, myocardial infarction, revascularization, or unstable angina. Read More

    Left bundle-branch block in patients with acute myocardial infarction: Presentation, treatment, and trends in outcome from 1997 to 2016 in routine clinical practice.
    Am Heart J 2017 Feb 10;184:106-113. Epub 2016 Nov 10.
    AMIS Plus Data Center, Epidemiology, Biostatistics and Prevention Institute, University of Zurich, Zurich, Switzerland. Electronic address:
    Background: Whether patients with acute myocardial infarction presenting with new or presumed new left bundle-branch block (LBBB) should be treated in the same way as those presenting with ST-elevation (STE) is still a matter of debate.

    Methods: Data from 28,358 patients enrolled in AMIS Plus from 1997 to 2016 were analyzed to evaluate differences in treatment and outcome of patients presenting with LBBB (n=2295) or STE (n=26,090) on their initial electrocardiogram using descriptive statistics and multivariate logistic regression.

    Results: LBBB patients were older (75. Read More

    The EXERRT trial: "EXErcise to Regadenoson in Recovery Trial": A phase 3b, open-label, parallel group, randomized, multicenter study to assess regadenoson administration following an inadequate exercise stress test as compared to regadenoson without exercise for myocardial perfusion imaging using a SPECT protocol.
    J Nucl Cardiol 2017 Feb 21. Epub 2017 Feb 21.
    Saint Luke's Mid America Heart Institute, Kansas City, MO, USA.
    Background: This study assessed the non-inferiority and safety of regadenoson administration during recovery from inadequate exercise compared with administration without exercise.

    Methods: Patients unable to achieve adequate exercise stress were randomized to regadenoson 0.4 mg either during recovery (Ex-Reg) or 1 hour after inadequate exercise (Regadenoson) (MPI1). Read More

    Next-Generation Stem Cell Therapy: Genetically Modified Mesenchymal Stem Cells for Cardiac Repair : Editorial to: "Mesenchymal Stem Cells with eNOS Over-Expression Enhance Cardiac Repair in Rats with Myocardial Infarction" by Leilei Chen et al.
    Cardiovasc Drugs Ther 2017 Feb 22. Epub 2017 Feb 22.
    Interdisciplinary Stem Cell Institute, University of Miami Miller School of Medicine, P.O Box 016960 (R125), Biomedical Research Building, 1501 N.W. 10th Ave. Room 908, Miami, FL, 33136, USA.

    Long-Term Administration of Eicosapentaenoic Acid Improves Post-Myocardial Infarction Cardiac Remodeling in Mice by Regulating Macrophage Polarization.
    J Am Heart Assoc 2017 Feb 21;6(2). Epub 2017 Feb 21.
    Department of Disease Control and Homeostasis, Graduate School of Medical Science, Kanazawa University, Kanazawa, Japan.
    Background: Consumption of n-3 fatty acids reduces the incidence of cardiovascular mortality in populations that consume diets rich in fish oil. Eicosapentaenoic acid (EPA) is an n-3 fatty acid known to reduce the frequency of nonfatal coronary events; however, the frequency of mortality after myocardial infarction (MI) is not reduced. The aims of this study were to determine whether long-term administration of EPA regulated cardiac remodeling after MI and to elucidate the underlying therapeutic mechanisms of EPA. Read More

    Unstable Saphenous Vein Graft Atheroma in Patients With Stable Angina Pectoris.
    Circ Cardiovasc Interv 2017 Mar;10(3)
    From the Department of Cardiology, Pulmonology, Hypertension and Nephrology, Ehime University Graduate School of Medicine, Toon, Japan (F.S., S.I., T.O., J.H.); Department of Cardiovascular Medicine, Ehime Prefectural Imabari Hospital, Imabari, Japan (F.S., H.K., T.M., A.O., H.M.); and Department of Cardiology, Kitaishikai Hospital, Ozu, Japan (S.I.).

    Outcomes of Coronary Artery Bypass and Stents for Unprotected Left Main Coronary Stenosis.
    Ann Thorac Surg 2017 Feb 18. Epub 2017 Feb 18.
    Faculty of Mathematics and Information Science, Shaanxi Normal University, Xi'an, China.
    Background: This study assessed the short-, medium-, and long-term outcomes of coronary artery bypass grafting vs stenting for patients with unprotected left main coronary artery disease through a meta-analysis of randomized controlled trials.

    Methods: PubMed, Embase, Scopus, Web of Science, Cochrane Library, and major conference proceedings databases were systematically searched for randomized controlled trials of coronary artery bypass grafting compared with stents in unprotected left main coronary artery disease. End points assessed were all-cause death, myocardial infarction, major adverse cardiac and cerebrovascular events, target vessel revascularization, and cerebral stroke. Read More

    Index complications predict secondary complications after infrainguinal lower extremity bypass for critical limb ischemia.
    J Vasc Surg 2017 Feb 17. Epub 2017 Feb 17.
    Division of Vascular and Endovascular Surgery, Boston Medical Center, Boston University School of Medicine, Boston, Mass. Electronic address:
    Objective: Patients undergoing lower extremity bypass (LEB) are at high risk of perioperative complications that can lead to a cascade of secondary complications. Our goal was to understand the association of index complications with secondary complications after LEB.

    Methods: The American College of Surgeons National Surgical Quality Improvement Program (ACS NSQIP) database from 2005 to 2012 was used to analyze secondary complications after five index complications after LEB: deep/organ space surgical site infection, urinary tract infection (UTI), myocardial infarction (MI), pneumonia, and acute renal failure (ARF). Read More

    Seasonal variations of temperature-related mortality burden from cardiovascular disease and myocardial infarction in China.
    Environ Pollut 2017 Feb 18. Epub 2017 Feb 18.
    State Key Laboratory of Infectious Disease Prevention and Control, Collaborative Innovation Center for Diagnosis and Treatment of Infectious Diseases, National Institute for Communicable Disease Control and Prevention, Chinese Center for Disease Control and Prevention, Beijing 102206, China. Electronic address:
    Incidence rate of cardiovascular disease (CVD) has significant seasonal trend, being higher in winter. However, the extent to which the seasonal variation of CVD deaths was caused by temperature remains unclear. We obtained daily data on temperature and CVD and myocardial infarction (MI) mortality from nine Chinese mega-cities during 2007-2013. Read More

    Association between Lp-PLA2 and coronary heart disease in Chinese patients.
    J Int Med Res 2017 Feb 12;45(1):159-169. Epub 2017 Jan 12.
    1 Department of Cardiology, Thoracic Clinical College, Tianjin Medical University, Tianjin, China.
    Objective To evaluate the association between plasma lipoprotein-associated phospholipase A2 (Lp-PLA2; known to release inflammatory mediators that promote atherosclerosis) and coronary heart disease (CHD) in Chinese patients. Methods This observational, cross-sectional study included a patient cohort who were assessed by coronary angiography and divided into patients with coronary heart disease and patients with normal coronary angiography (controls). Data for several biochemical indicators were collected. Read More

    Simultaneous bilateral retinal detachment following coronary artery bypass graft: Case report.
    Eur J Ophthalmol 2007 Sep-Oct;17(1):860-863
    Eye Clinic, Department of Neurological and Visual Sciences, University of Verona, Verona - Italy.
    Purpose: To present an unusual case of simultaneous bilateral retinal detachment (RD) following a coronary artery bypass graft in a patient with acute myocardial infarction (AMI).

    Methods: A 78-year-old man was first seen for bilateral sudden visual loss after surgical treatment of AMI. The patient underwent ultrasound biomicroscopy (UBM) and ocular B-scan echographic examination. Read More

    Elastase-2, an angiotensin II-generating enzyme, contributes to increased Ang II in resistance arteries of mice with myocardial infarction.
    Br J Pharmacol 2017 Feb 21. Epub 2017 Feb 21.
    Departments of Pharmacology, Ribeirao Preto Medical School, University of Sao Paulo, Ribeirao Preto, SP, Brazil.
    Angiotensin II (Ang II), whose generation largely depends on angiotensin-converting enzyme activity, mediates most of the renin-angiotensin-system effects. Elastase-2 (ELA-2), a chymotrypsin-serine protease elastase family member 2A, alternatively generates Ang II in rat arteries. Myocardial infarction (MI) leads to intense RAS activation, but mechanisms involved on Ang II-generation in resistance arteries are unknown. Read More

    Cardiovascular Disease in Relation to Placental Abruption: A Population-Based Cohort Study from Denmark.
    Paediatr Perinat Epidemiol 2017 Feb 21. Epub 2017 Feb 21.
    Department of Public Health, University of Copenhagen, Copenhagen, Denmark.
    Background: Cardiovascular (CVD) complications stemming from vascular dysfunction have been widely explored in the setting of preeclampsia. However, the impact of abruption, a strong indicator of microvascular disturbance, on the risk of CVD mortality and morbidity remains poorly characterised.

    Methods: We designed a cohort analysis of 828 289 women who delivered singletons in Denmark between 1978 and 2010. Read More

    Arterial structure and function in subjects with acute coronary syndrome after one-year of treatment.
    Pol Arch Med Wewn 2017 Feb 15. Epub 2017 Feb 15.
    INTRODUCTION    It is controversial whether the modification of arterial stiffness and intima-media thickness (IMT) is plausible in patients with clinically significant atherosclerosis.  OBJECTIVES    We evaluated the effects of the one-year pharmacological therapy on the arterial stiffness and IMT in survivors of non-ST elevation myocardial infarction (NSTEMI) who were treated according to the clinical guidelines.  PATIENTS AND METHODS    For this study 298 NSTEMI patients (median age 64 years; 85 females) were enrolled. Read More

    The influence of targeted temperature management on the pharmacokinetics of drugs administered during and after cardiac arrest: a systematic review.
    Acta Clin Belg 2017 Feb 21:1-7. Epub 2017 Feb 21.
    a Faculty of Medicine and Health Sciences , Ghent University , Ghent , Belgium.
    Objective: Pharmacokinetic parameters of drugs are widely investigated under normothermic conditions and normal hemodynamic parameters. The European Resuscitation Council recommends the use of targeted temperature management (TTM) with a target temperature of 34 °C in cardiac arrest (CA) patients. The aim of this literature review is to investigate the influence of CA combined with TTM on the pharmacokinetics of drugs. Read More

    Robot-Assisted Approach to W Configuration Urinary Diversion:A Step-by-Step Technique.
    BJU Int 2017 Feb 20. Epub 2017 Feb 20.
    Department of Urology, Roswell Park Cancer Institute, Buffalo, NY.
    Introduction: To describe a detailed step-by-step approach of our technique to robot-assisted intracorporeal "W" orthotopic ileal neobladder (ICNB).

    Methods: Five patients underwent robot-assisted radical cystectomy (RARC), extended pelvic lymph node dissection (ePLND) and ICNB. ICNB was divided into 6 key steps to facilitate and enable a detailed analysis and auditing of the technique. Read More

    Renal denervation for resistant hypertension.
    Cochrane Database Syst Rev 2017 Feb 21;2:CD011499. Epub 2017 Feb 21.
    Institute of Clinical Physiology, CNR - Italian National Council of Research, CNR-IFC Via Vallone Petrara c/o Ospedali Riuniti, Reggio Calabria, Italy, 89100.
    Background: Resistant hypertension is highly prevalent among the general hypertensive population and the clinical management of this condition remains problematic. Different approaches, including a more intensified antihypertensive therapy, lifestyle modifications, or both, have largely failed to improve patients' outcomes and to reduce cardiovascular and renal risk. As renal sympathetic hyperactivity is a major driver of resistant hypertension, renal sympathetic ablation (renal denervation) has been recently proposed as a possible therapeutic alternative to treat this condition. Read More

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