Biochem Biophys Res Commun 2017 Sep 20. Epub 2017 Sep 20.
Department of Cardiology, The First Affiliated Hospital, Harbin Medical University, Harbin 150001, China; Key Laboratory of Cardiac Diseases and Heart Failure, Harbin Medical University, Harbin 150001, China; Institute of Metabolic Disease, Heilongjiang Academy of Medical Science, Harbin 150081, China. Electronic address:
Cardiac fibrosis is a pathological feature common to a variety of heart diseases such as myocardial infarction, arrhythmias, cardiomyopathies and heart failure. Emerging data has indicted that autophagy is involved in fibrotic synthesis. Relaxin as a pleiotropic hormone can attenuate cardiac fibrosis and hypertrophy, however the exact molecular mechanism remains largely unknown. Read More