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    A Critical Review of the Consensus Statement from the European Atherosclerosis Society Consensus Panel 2017.
    Pharmacology 2018 Jan 19;101(3-4):184-218. Epub 2018 Jan 19.
    Medical Corporation Uchinokai, Kumamoto, Japan.
    Background: The Consensus Statement from the European Atherosclerosis Society (EAS) Consensus Panel 2017 concludes on the basis of 3 different types of clinical studies that low-density lipoprotein (LDL) causes atherosclerotic cardiovascular disease (ASCVD). In Mendelian randomization studies, rare genetic mutations affecting LDL receptor function were found to cause higher or lower LDL-C levels, which are associated with correspondingly altered ASCVD risk. In prospective cohort studies and randomized controlled trials (RCTs) of statins, a remarkably consistent log-linear association was demonstrated between the absolute magnitude of LDL-C exposure and ASCVD risk. Read More

    Cardiovascular Safety, Long-Term Noncardiovascular Safety, and Efficacy of Sodium-Glucose Cotransporter 2 Inhibitors in Patients With Type 2 Diabetes Mellitus: A Systemic Review and Meta-Analysis With Trial Sequential Analysis.
    J Am Heart Assoc 2018 Jan 20;7(2). Epub 2018 Jan 20.
    Department of Cardiology, Affiliated Drum Tower Hospital, Nanjing University School of Medicine, Nanjing, China
    Background: The cardiovascular and long-term noncardiovascular safety and efficacy of SGLT2 (sodium-glucose cotransporter 2) inhibitors have not been well documented.

    Methods And Results: For cardiovascular outcomes, we performed a meta-analysis with trial sequential analysis of randomized controlled trials and adjusted observational studies, each with a minimum of 26 weeks and 2000 patient-years of follow-up. For long-term noncardiovascular safety and efficacy outcome analyses, we included only randomized controlled trials with at least 2 years and 1000 patient-years of follow-up. Read More

    Cardiac Events after Non-Cardiac Surgery in Patients Undergoing Pre-Operative Dobutamine Stress Echocardiography Findings From the Mayo Poce-DSE Investigators.
    Am J Med 2018 Jan 15. Epub 2018 Jan 15.
    Department of Internal Medicine, Division of General Internal Medicine, Mayo Clinic, Rochester MN. Electronic address:
    Background: Current guidelines support the use of dobutamine stress echocardiography (DSE) prior to non-cardiac surgery in higher risk patients who are unable to perform at least 4 metabolic equivalents of physical activity. We evaluated post-operative outcomes of patients in different operative risk categories after pre-operative DSE.

    Methods: We collected data from the medical record on 4,494 patients from January 1, 2006 to December 31, 2011 who had DSE up to 90 days prior to a non-cardiac surgery. Read More

    Cardiac repair by epicardial EMT: Current targets and a potential role for the primary cilium.
    Pharmacol Ther 2018 Jan 17. Epub 2018 Jan 17.
    Department of Physiology and Pharmacology, Schulich School of Medicine and Dentistry, University of Western Ontario, London, Ontario, Canada. Electronic address:
    Despite therapeutic advances that have prolonged life, myocardial infarction (MI) remains a leading cause of death worldwide and imparts a significant economic burden. The advancement of treatments to improve cardiac repair post-MI requires the discovery of new targeted treatment strategies. Recent studies have highlighted the importance of the epicardial covering of the heart in both cardiac development and lower vertebrate cardiac regeneration. Read More

    High sensitivity troponin in the management of tachyarrhythmias.
    Cardiovasc Revasc Med 2017 Nov 28. Epub 2017 Nov 28.
    Wessex Cardiothoracic Centre, University Hospital Southampton NHS Foundation Trust, UK; Faculty of Medicine, University of Southampton, Southampton, UK. Electronic address:
    Background: The introduction of the highly sensitive troponin (hs-trop) assays into clinical practice has allowed for the more rapid diagnosis or exclusion of type 1 myocardial infarctions (T1MI) by clinicians, in addition type 2 myocardial infarctions (T2MI) are now more frequently detected. Tachyarrhythmias are one of the common causes of T2MI, the medium and long term outcome for this cohort of T2MI is yet to be clarified.

    Methods: Retrospective review of consecutive patients admitted with a diagnosis of either (a) non ST-elevation myocardial infarction (NSTEMI) or (b) tachyarrhythmia was performed. Read More

    Adopting an early invasive strategy for non-ST-elevation myocardial infarction: Analysis of the Portuguese Registry on Acute Coronary Syndromes.
    Rev Port Cardiol 2018 Jan 15. Epub 2018 Jan 15.
    Serviço de Cardiologia, Hospital Garcia de Orta, EPE, Almada, Portugal; Laboratório de Farmacologia Clínica e Terapêutica, Faculdade de Medicina da Universidade de Lisboa, Lisboa, Portugal.
    Introduction: In patients with non-ST-elevation myocardial infarction (NSTEMI), the best timing for coronary angiography is not definitely established, although it is recognized that in high-risk patients it should be performed within the first 24 hours. The aim of this work was to describe the evolution over time of the use of an invasive strategy in the treatment of NSTEMI and in-hospital mortality.

    Methods: We performed a retrospective analysis of patients admitted with NSTEMI included in the Portuguese Registry on Acute Coronary Syndromes (ProACS) between 2002 and 2015. Read More

    The NLRP3 inflammasome and the emerging role of colchicine to inhibit atherosclerosis-associated inflammation.
    Atherosclerosis 2017 Dec 25. Epub 2017 Dec 25.
    Department of Cardiology, Royal Prince Alfred Hospital, Sydney Medical School, The University of Sydney, Heart Research Institute, Sydney, New South Wales, Australia. Electronic address:
    Atherosclerosis is considered a chronic inflammatory disease of the arterial wall. Recently, compelling evidence has arisen for the role of monocytes and neutrophils and a particular protein complex that resides within these cells - the NLRP3 inflammasome - in atherosclerosis-associated inflammation. It is now also known that cholesterol crystals are present through all stages of atherosclerosis and can activate the NLRP3 inflammasome within these inflammatory cells to produce interleukin 1β and interleukin 18 - key mediators in the inflammatory cascade that drive plaque progression and instability. Read More

    Inhibition of BRD4 Attenuates Cardiomyocyte Apoptosis via NF-κB pathway in a Rat Model of Myocardial Infarction.
    Cardiovasc Ther 2018 Jan 20. Epub 2018 Jan 20.
    Department of Physiology and Pathophysiology, School of Basic Medical Science, Tianjin Medical University, Heping, Tianjin, 300070, China.
    Myocardial infarction (MI) remains the most common cause of heart failure (HF) worldwide. For almost 50 years, HF has been recognized as a determinant of adverse prognosis after MI, but efforts to promote myocardial repair have failed to be translated into clinical therapies. In the present study, we investigated the effects of BRD4 on cardiac function and the underlying mechanism. Read More

    Autophagy promotes MSC-mediated vascularization in cutaneous wound healing via regulation of VEGF secretion.
    Cell Death Dis 2018 Jan 19;9(2):58. Epub 2018 Jan 19.
    State Key Laboratory of Military Stomatology & National Clinical Research Center for Oral Diseases & Shaanxi International Joint Research Center for Oral Diseases, Center for Tissue Engineering, School of Stomatology, The Fourth Military Medical University, Xi'an, Shaanxi, 710032, China.
    Vascularization deficiency caused a lot of diseases, such as diabetes ulcer and myocardial infarction. Mesenchymal stem cells (MSCs), with the self-renewal and multipotent differentiation capacities, have been used for many diseases treatment through regulation microenvironment. Numerous studies reported that MSCs transplantation could largely improve cutaneous wound healing via paracrine secretion of growth factors. Read More

    Effects of genetic variants on platelet reactivity and one-year clinical outcomes after percutaneous coronary intervention: A prospective multicentre registry study.
    Sci Rep 2018 Jan 19;8(1):1229. Epub 2018 Jan 19.
    Department of Cardiology, Cardiovascular Center, Korea University Anam Hospital, Seoul, South Korea.
    Clopidogrel is the mainstay for antiplatelet treatment after percutaneous coronary intervention (PCI). The relationship of platelet reactivity and genetic polymorphism with clinical outcomes with newer-generation drug-eluting stents is unclear. We analysed 4,587 patients for the most powerful single-nucleotide polymorphisms (CYP2C19, CYP2C9, ABCB1, PON1, and P2Y12) related to on-treatment platelet reactivity (OPR). Read More

    Excessive Daytime Sleepiness Independently Predicts Increased Cardiovascular Risk After Myocardial Infarction.
    J Am Heart Assoc 2018 Jan 19;7(2). Epub 2018 Jan 19.
    Department of Cardiovascular Medicine, Mayo Clinic, Rochester, MN
    Background: Excessive daytime sleepiness (EDS), a common symptom among patients with sleep-disordered breathing, is closely associated with the development of cardiovascular diseases, but its long-term prognostic value is not completely understood. The aim of this study was to investigate whether EDS would be an independent prognostic factor after myocardial infarction.

    Methods And Results: We prospectively recruited 112 post-myocardial infarction patients. Read More

    Sex and Race Differences in Lifetime Risk of Heart Failure with Preserved Ejection Fraction and Heart Failure with Reduced Ejection Fraction.
    Circulation 2018 Jan 19. Epub 2018 Jan 19.
    Division of Cardiology, UTSW Medical Center, Dallas, TX & Department of Clinical Sciences, UTSW Medical Center, Dallas, TX
    Background -Lifetime risk of heart failure has been estimated to range from 20% to 46% in diverse sex and race groups. However, lifetime risk estimates for the two HF phenotypes, HF with preserved ejection fraction (HFpEF) and HF with reduced ejection fraction (HFrEF), is not known. Methods -Participant-level data from 2 large prospective cohort studies, the Cardiovascular Health Study (CHS) and the Multiethnic Study of Atherosclerosis (MESA), were pooled excluding individuals with prevalent HF at baseline. Read More

    Risk factors for first-time acute myocardial infarction patients in Trinidad.
    BMC Public Health 2018 Jan 19;18(1):161. Epub 2018 Jan 19.
    School of Medicine, Faculty of Medical Sciences, University of the West Indies, Eric Williams Medical Sciences Complex, Mt. Hope, Trinidad, Trinidad and Tobago.
    Background: The relative importance of coronary artery disease (CAD) risk varies globally. The aim of this study was to determine CAD risk factors for acute myocardial infarction (AMI) among patients in public health care institutions in Trinidad using a case-control type study design.

    Methods: The sample comprised 251 AMI patients hospitalized between March 1, 2011 and April 30, 2012 and 464 age- and sex-matched non-AMI patients with no terminal or life-threatening illness and who did not undergo treatment for CAD. Read More

    Prospective Multicenter Assessment of All-Cause Mortality Following Surgery for Adult Cervical Deformity.
    Neurosurgery 2018 Jan 17. Epub 2018 Jan 17.
    Department of Neurological Surgery, University of California, San Francisco, San Francisco, California.
    Background: Surgical treatments for adult cervical spinal deformity (ACSD) are often complex and have high complication rates.

    Objective: To assess all-cause mortality following ACSD surgery.

    Methods: ACSD patients presenting for surgical treatment were identified from a prospectively collected multicenter database. Read More

    Takotsubo Cardiomyopathy Associated With Work-Place Bullying.
    Occup Med (Lond) 2018 Jan 17. Epub 2018 Jan 17.
    Royal Darwin Hospital, Australia.
    Background: Takotsubo cardiomyopathy (TC) is a condition of transient left ventricular dysfunction precipitated by acute physical or emotional stress. The pathogenesis of TC is not well understood, but it is known to predominantly affect postmenopausal women in the context of physical or emotional triggers.

    Aims: To describe a case of TC with an association to a never previously described work place stressor of bullying. Read More

    ST-segment elevation myocardial infarction caused by aortic pseudoaneurysm following surgical mitral valvuloplasty.
    Eur J Cardiothorac Surg 2018 Jan 16. Epub 2018 Jan 16.
    Interventional Cardiology Unit, New Tokyo Hospital, Chiba, Japan.
    Pseudoaneurysm is one of the complications after arterial cannulation. We report the case of a patient with ST-segment elevation myocardial infarction due to aortic pseudoaneurysm after surgical mitralvalvuloplasty. Careful evaluation should be performed in cases of ST-segment elevation myocardial infarction following cardiac surgery, even after several months. Read More

    Effects of night-time and weekend admissions on in-hospital mortality in acute myocardial infarction patients in Japan.
    PLoS One 2018 19;13(1):e0191460. Epub 2018 Jan 19.
    Department of Healthcare Economics and Quality Management, Graduate School of Medicine, Kyoto University, Sakyo-ku, Japan.
    Background: Patients admitted to hospital during off-hours may experience poorer quality of care and clinical outcomes. However, few studies have examined the variations in clinical processes and outcomes across admission times and days of the week in acute myocardial infarction (AMI) patients. This study aimed to comparatively analyze the effect of weekend and weekday admissions stratified by admission time on in-hospital mortality in AMI patients. Read More

    Guidelines for Experimental Models of Myocardial Ischemia and Infarction.
    Am J Physiol Heart Circ Physiol 2018 Jan 12. Epub 2018 Jan 12.
    Institut fur Pathophysiologie, Universitatsklinikum Essen, Germany.
    Myocardial infarction is a prevalent major cardiovascular event that arises from myocardial ischemia with or without reperfusion, and basic and translational research is needed to better understand its underlying mechanisms and consequences for cardiac structure and function. Ischemia underlies a broad range of clinical scenarios ranging from angina to hibernation to permanent occlusion, and while reperfusion is mandatory for salvage from ischemic injury, reperfusion also inflicts injury on its own. In this consensus statement, we present recommendations for animal models of myocardial ischemia and infarction. Read More

    A Review of Analytical Methods for the determination of Clopidogrel in Pharmaceuticals and Biological Matrices.
    Crit Rev Anal Chem 2018 Jan 19. Epub 2018 Jan 19.
    a Department of Pharmaceutical Analysis , SRM College of Pharmacy, SRM University, Kattankulathur , Kanchipuram 603203 , Tamil Nadu , India.
    P2Y12 belongs to a group of G protein - coupled (GPCR) purinergic receptors and is a receptor for adenosine diphosphate (ADP). The P2Y12 receptor is involved in platelet aggregation and acts as a biological target for treating thromboembolisms and other clotting disorders. The use of Clopidogrel (CLO) has improved the morbidity and mortality endpoints including cardiovascular death, recurrent myocardial infarction (MI) and stroke at 30 days after percutaneous coronary intervention (PCI). Read More

    Takotsubo cardiomyopathy in an ultra-centenarian woman.
    Acta Biomed 2018 Jan 16;88(4):529-532. Epub 2018 Jan 16.
    University Hospital of Parma.
    A 101 years-old woman was admitted to our Emergency Department (ED) for acute dyspnea which onset nearly two hours before presentation. She had been on hydrochlorothyazyde-amiloride therapy due to mild hypertension. No other relevant features were present in the clinical history. Read More

    Electronic health record problem lists: accurate enough for risk adjustment?
    Am J Manag Care 2018 Jan 1;24(1):e24-e29. Epub 2018 Jan 1.
    Cedars-Sinai Medical Center, 8635 W 3rd St, Ste 1070W, Los Angeles, CA 90048. Email:
    Objectives: To determine whether comorbidity information derived from electronic health record (EHR) problem lists is accurate.

    Study Design: Retrospective cohort study of 1596 men diagnosed with prostate cancer between 1998 and 2004 at 2 Southern California Veterans Affairs Medical Centers with long-term follow-up.

    Methods: We compared EHR problem list-based comorbidity assessment with manual review of EHR free-text notes in terms of sensitivity and specificity for identification of major comorbidities and Charlson Comorbidity Index (CCI) scores. Read More

    Diagnostic and prognostic micro-RNAs in ischemic stroke due to carotid artery stenosis and in acute coronary syndrome: the 4-year prospective study.
    Kardiol Pol 2018 Jan 19. Epub 2018 Jan 19.
    Department of Interventional Cardiology, Jagiellonian University School of Medicine, the John Paul II Hospital, Krakow, Poland.
    Background: Circulating microRNAs (miRs) levels are potentially important diagnostic and prognostic biomarkers in acute coronary syndrome (ACS) or cerebral ischemic event (CIE) resulting from internal carotid artery stenosis (ICAS).

    Aim: This 4-year prospective study aimed to compare the levels of circulating miRs in ACS vs CIE patients, and investigate miRs potentially associated with risk of recurrent cardiovascular event.

    Methods: The circulating miRs levels (miR-1-3p, miR-16-5p, miR-34a-5p, mir-122-5p, miR-124-3p, miR-133a-3p, miR-133b, miR-134-5p, miR-208b-3p, miR-375 and miR-499-5p) were compared in 43 (34M, 57. Read More

    Chronic statin treatment is a predictor of pre-interventional infarct related artery patency in patients with ST elevation myocardial infarction treated with percutaneous coronary intervention.
    Kardiol Pol 2018 Jan 19. Epub 2018 Jan 19.
    Adana Numune Education and Research Hospital, Adana, Turkey.
    Background: Beyond lipid-lowering effects, early statin treatment has beneficial effects on prognosis after acute coronary syndrome. Infarct related artery patency before percutaneous coronary intervention is known to be a strong predictor of improved clinical outcome.

    Aim: We aimed to investigate the effects of chronic statin treatment before admission on the infarct related artery patency after infarction. Read More

    Impact of previous cardiac surgery with sternotomy on clinical outcomes and quality of life after transcatheter aortic valve implantation for severe aortic stenosis.
    Kardiol Pol 2018 Jan 19. Epub 2018 Jan 19.
    2nd Department of Cardiology, Institute of Cardiology, Jagiellonian University, Medical College, Krakow, Poland.
    Background: Transcatheter aortic valve implantation (TAVI) has evolved as effective treatment in patients with symptomatic severe aortic stenosis (AS) and increased operative risk. Data on the influence of previous sternotomy on the risk of TAVI are limited.

    Aim: We sought to investigate the impact of previous cardiac surgery with sternotomy on clinical outcomes and quality of life (QoL) after TAVI. Read More

    Risk factors for adverse outcomes of acute coronary syndrome patients - single center experience in long term follow-up of treated patients.
    Kardiol Pol 2018 Jan 19. Epub 2018 Jan 19.
    1st Department of Cardiology, Medical University of Warsaw, Warsaw, Poland.
    Background: For patients experiencing an acute coronary syndrome (ACS), a crucial time to assess their prognosis and future management is at discharge from hospital.

    Aim: To identify patients' risk factors of mortality during post-discharge period following an ACS hospitalization.

    Methods: We studied 672 consecutive ACS patients hospitalized and discharged alive between 2002 and 2004. Read More

    Patients treated with bivalirudin still at higher risk of stent thrombosis: a comprehensive meta-analysis of randomized clinical trials of bivalirudin and heparin for percutaneous coronary interventions.
    Kardiol Pol 2018 Jan 19. Epub 2018 Jan 19.
    I Klinika Kardiologii Katedry Kardiologii Uniwersytet Medyczny, Poznań.
    Background: Although the current practice guidelines recommend using both heparin and bivalirudin for percutaneous coronary interventions (PCI), the research data are ambiguous.

    Aim: To compare the impact of bivalirudin- and heparin on major clinical endpoints in PCI patients with particular emphasis on periprocedural stent thrombosis.

    Methods: Total of 18 randomised clinical trials involving 41752 subjects were included. Read More

    Direct transfer of STEMI patients to cardiac catheterization laboratory : Prognostic relevance for in-hospital mortality.
    Herz 2018 Jan 19. Epub 2018 Jan 19.
    Mid-German Heart Center, Department of Internal Medicine III, Division of Cardiology, Angiology and Intensive Medical Care, University Hospital Halle, Martin-Luther-University Halle, Ernst-Grube-Straße 40, 06120, Halle (Saale), Germany.
    Background: Although the incidence of acute myocardial infarction and in-hospital mortality after ST-elevation myocardial infarction (STEMI) has declined substantially in countries that have established primary percutaneous coronary interventions (pPCI) over the past two decades, coronary artery disease remains a major cause of morbidity and mortality worldwide. We aimed to examine whether the direct transfer of STEMI patients to the cardiac catheterization laboratory (CCL) had a prognostic effect on in-hospital mortality in patients who underwent pPCI after STEMI.

    Methods: The in-house mortality of STEMI patients who underwent pPCI was assessed at the Department of Cardiology, Harzklinik Goslar, Germany, between April 2013 and June 2017. Read More

    The adverse effects of environmental noise exposure on oxidative stress and cardiovascular risk.
    Antioxid Redox Signal 2018 Jan 19. Epub 2018 Jan 19.
    University Hospital Mainz, 2nd Medical Clinics - Cardiology , Obere Zahlbacher Str. 63 , V-Bau 911, 00349 , Mainz, Germany , 55101.
    Epidemiological studies have provided evidence that traffic noise exposure is linked to cardiovascular diseases such as arterial hypertension, myocardial infarction and stroke. Noise is a non-specific stressor that activates the autonomous nervous system and endocrine signaling. According to the noise reaction model introduced by Babisch and colleagues, chronic low levels of noise can cause so called non-auditory effects, such as disturbances of activity, sleep and communication, which can trigger a number of emotional responses, including annoyance and subsequent stress. Read More

    Two-year results after coronary stenting of small vessels in Japanese population using 2.25-mm diameter sirolimus-eluting stent with bioresorbable polymer: primary and long-term outcomes of CENTURY JSV study.
    Cardiovasc Interv Ther 2018 Jan 18. Epub 2018 Jan 18.
    Department of Cardiology, Kurashiki Central Hospital, Kurashiki, Japan.
    Percutaneous coronary intervention (PCI) in coronary artery disease (CAD) with very small vessels remains challenging. The aim of this study is to evaluate the safety and effectiveness of the 2.25-mm diameter Ultimaster sirolimus-eluting stent in the treatment of Japanese patients with CAD due to lesions in very small vessels. Read More

    The Incidence and the Prognostic Impact of Acute Kidney Injury in Acute Myocardial Infarction Patients: Current Preventive Strategies.
    Cardiovasc Drugs Ther 2018 Jan 19. Epub 2018 Jan 19.
    Cardiology Department, Medical School, Democritus University of Thrace, Alexandroupolis, Greece.
    Acute kidney injury (AKI) is one of the most common complications during hospitalization in various clinical settings. The goal of this review was to assess the incidence of AKI in acute myocardial infarction patients (AMI), how this incidence is affected by the diverse definitions, and if there is variability in the reported rates over recent years. Additionally, we sought to appraise the impact of AKI on short- and long-term prognosis of these patients. Read More

    Does Statin Benefits Patients with Heart Failure Undergoing Percutaneous Coronary Intervention? Findings from the Melbourne Interventional Group Registry.
    Cardiovasc Drugs Ther 2018 Jan 18. Epub 2018 Jan 18.
    Centre of Cardiovascular Research & Education (CCRE) in Therapeutics, Department of Epidemiology and Preventive Medicine, Monash University, Commercial Road, Melbourne, VIC, 3004, Australia.
    Purpose: The effectiveness of statins in improving clinical outcomes among patients with heart failure (HF) undergoing percutaneous coronary intervention (PCI) is unclear. We examined the association between use of statins and clinical outcomes in patients with HF included in the Melbourne Interventional Group registry.

    Methods: Patients were followed from 30 days to 1 year post-PCI for a primary composite outcome of all-cause mortality and hospitalisation for cardiovascular (CV) causes. Read More

    Outcomes in syncope research: a systematic review and critical appraisal.
    Intern Emerg Med 2018 Jan 18. Epub 2018 Jan 18.
    Dipartimento di Medicina Interna, Fondazione IRCCS Ca' Granda, Ospedale Maggiore Policlinico, Via Francesco Sforza 35, 20122, Milan, Italy.
    Syncope is the common clinical manifestation of different diseases, and this makes it difficult to define what outcomes should be considered in prognostic studies. The aim of this study is to critically analyze the outcomes considered in syncope studies through systematic review and expert consensus. We performed a systematic review of the literature to identify prospective studies enrolling consecutive patients presenting to the Emergency Department with syncope, with data on the characteristics and incidence of short-term outcomes. Read More

    Amphiregulin enhances cardiac fibrosis and aggravates cardiac dysfunction in mice with experimental myocardial infarction partly through activating EGFR-dependent pathway.
    Basic Res Cardiol 2018 Jan 18;113(2):12. Epub 2018 Jan 18.
    Department of Cardiology, Shanghai Jiao Tong University Affiliated Sixth People's Hospital, 600 Yishan Road, Shanghai, 200233, China.
    Cardiac fibrosis (CF), a main process of ventricular remodeling after myocardial infarction (MI), plays a crucial role in the pathogenesis of heart failure (HF) post-MI. It is known that amphiregulin (AR) is involved in fibrosis of several organs. However, the expression of AR and its role post-MI are yet to be determined. Read More

    Effect of fibrillatory wave amplitude on coronary blood flow as assessed by thrombolysis in myocardial infarction frame count in patients with atrial fibrillation.
    Heart Vessels 2018 Jan 18. Epub 2018 Jan 18.
    Department of Cardiovascular Medicine, Hiroshima University Graduate School of Biomedical and Health Sciences, 1-2-3, Kasumi-cho, Minami-ku, Hiroshima, 734-8551, Japan.
    Atrial fibrillation (AF) is the most common arrhythmia, characterized by a lack of atrial contraction and an irregular ventricular rhythm. We assessed the effect of fibrillatory wave amplitude on coronary blood flow in patients with AF using the thrombolysis in myocardial infarction (TIMI) frame count. Sixty-one patients with AF persisting for longer than 30 days were included. Read More

    Risk of discontinuation of clopidogrel after 1 month following bare-metal stents: a propensity-score adjusted comparison with continued administration of clopidogrel after drug-eluting stents.
    J Thromb Thrombolysis 2018 Jan 18. Epub 2018 Jan 18.
    Department of Cardiology and Angiology II, University Heart Center Freiburg · Bad Krozingen, Suedring 15, 79189, Bad Krozingen, Germany.
    In patients at high risk for bleeding undergoing percutaneous coronary intervention (PCI) the use of bare-metal-stent (BMS) is considered an option that allows discontinuation of clopidogrel after 4 weeks. We sought to investigate the risk of early discontinuation of clopidogrel in patients with BMS as compared with a 6-month course of clopidogrel after DES in patients with or without high on-treatment platelet reactivity (HTPR). In 765 consecutive patients undergoing PCI after loading with clopidogrel 600 mg, HTPR was tested by optical aggregometry and defined as residual platelet reactivity > 14%. Read More

    Delayed Presentation of Cerebral Air Embolism from a Left Atrial-Esophageal Fistula: A Case Report and Review of the Literature.
    Cureus 2017 Nov 15;9(11):e1850. Epub 2017 Nov 15.
    Neurosurgery, Seattle Science Foundation.
    Air embolism developing from an atrial-esophageal fistula that was created as a complication from an atrial ablation procedure is a rare, yet usually fatal diagnosis. Neurologic manifestations such as meningitis, altered mental status, seizures, strokes, transient ischemic attacks (TIAs), psychiatric changes, and coma can ensue. Imaging of the brain might reveal infarcts, cerebral edema, as well as signs of pneumocephalus. Read More

    SDF1 gradient associates with the distribution of c-Kit+ cardiac cells in the heart.
    Sci Rep 2018 Jan 18;8(1):1160. Epub 2018 Jan 18.
    Biocenter Oulu, Faculty of Biochemistry and Molecular Medicine, Oulu Center for Cell-Matrix Research, University of Oulu, Oulu, Finland.
    Identification of the adult cardiac stem cells (CSCs) has offered new therapeutic possibilities for treating ischemic myocardium. CSCs positive for the cell surface antigen c-Kit are known as the primary source for cardiac regeneration. Accumulating evidence shows that chemokines play important roles in stem cell homing. Read More

    ST Elevation in Lead aVR and Its Association with Clinical Outcomes.
    Acta Med Indones 2017 Oct;49(4):347-350
    Department of Internal Medicine, Faculty of Medicine Universitas Indonesia - Cipto Mangunkusumo, Jakarta, Indonesia..
    The purpose of this case repots are to evaluate the role of ST elevation in aVR lead and to make analysis between both cases. There are some atypical electrocardiogram (ECG) presentations which need prompt management in patient with ischemic clinical manifestation such as ST elevation in aVR lead. In this case study, we report a 68-year old woman with chief symptoms of shortness of breath and chest discomfort. Read More

    Long-Term Risk of Myocardial Infarction Compared to Recurrent Stroke After Transient Ischemic Attack and Ischemic Stroke: Systematic Review and Meta-Analysis.
    J Am Heart Assoc 2018 Jan 18;7(2). Epub 2018 Jan 18.
    Normandie Université UNICAEN, Inserm U1237 CHU Caen, Caen, France
    Background: Uncertainties remain about the current risk of myocardial infarction (MI) after ischemic stroke or transient ischemic attack.

    Methods And Results: We undertook a systematic review to estimate the long-term risk of MI, compared to recurrent stroke, with temporal trends in ischemic stroke/transient ischemic attack patients. Annual risks and 95% confidence intervals (95% CI) of MI and recurrent stroke were estimated using random-effect meta-analyses. Read More

    Vancomycin-induced coronary artery spasm: a case of Kounis syndrome.
    BMJ Case Rep 2018 Jan 17;2018. Epub 2018 Jan 17.
    Department of Pulmonary and Critical Care Medicine, New York Presbyterian Hospital Queens, New York, USA.
    Kounis syndrome defined as the appearance of acute coronary syndrome in the context of an allergic reaction is a relatively rare phenomenon. There are three variants of this syndrome in which the patient presents with symptoms of an acute chest. Herein, we describe a case of an 83-year-old woman who demonstrated type I variant of Kounis syndrome in response to vancomycin administration. Read More

    Hypertension and Atrial Fibrillation: Doubts and Certainties From Basic and Clinical Studies.
    Circ Res 2018 Jan;122(2):352-368
    From the Struttura Complessa di Medicina, Dipartimento di Medicina, Ospedale di Assisi, Italy (P.V.); and Struttura Complessa di Cardiologia e Fisiopatologia Cardiovascolare, Dipartimento di Cardiologia (F.A.) and Dipartimento di Medicina Interna (G.R.), Università di Perugia, Italy.
    Hypertension and atrial fibrillation (AF) are 2 important public health priorities. Their prevalence is increasing worldwide, and the 2 conditions often coexist in the same patient. Hypertension and AF are strikingly related to an excess risk of cardiovascular disease and death. Read More

    Circulating Platelets as Mediators of Immunity, Inflammation, and Thrombosis.
    Circ Res 2018 Jan;122(2):337-351
    From the Division of Cardiovascular Medicine, Department of Medicine, University of Massachusetts Medical School, Worcester.
    Platelets, non-nucleated blood components first described over 130 years ago, are recognized as the primary cell regulating hemostasis and thrombosis. The vascular importance of platelets has been attributed to their essential role in thrombosis, mediating myocardial infarction, stroke, and venous thromboembolism. Increasing knowledge on the platelets' role in the vasculature has led to many advances in understanding not only how platelets interact with the vessel wall but also how they convey changes in the environment to other circulating cells. Read More

    Health Care Costs Associated With Incident Complications in Patients With Type 2 Diabetes in Germany.
    Diabetes Care 2018 Jan 18. Epub 2018 Jan 18.
    Institute of Health Economics and Health Care Management, Helmholtz Zentrum München (GmbH)-German Research Center for Environmental Health (GmbH), Neuherberg, Germany.
    Objective: The aim of this study is to provide reliable regression-based estimates of costs associated with different type 2 diabetes complications.

    Research Design And Methods: We used nationwide statutory health insurance (SHI) data from 316,220 patients with type 2 diabetes. Costs for inpatient and outpatient care, pharmaceuticals, rehabilitation, and nonmedical aids and appliances were assessed in the years 2013-2015. Read More

    Impaired Recovery of Left Ventricular Function in Patients With Cardiomyopathy and Left Bundle Branch Block.
    J Am Coll Cardiol 2018 Jan;71(3):306-317
    Division of Cardiology, Department of Medicine, Duke University, Durham, North Carolina; Duke Clinical Research Institute, Duke University, Durham, North Carolina. Electronic address:
    Background: Patients with left bundle branch block (LBBB) often respond to cardiac resynchronization therapy (CRT) with left ventricular ejection fraction (LVEF) improvement. Guideline-directed medical therapy (GDMT), not CRT, is first-line therapy for patients with reduced LVEF with LBBB. However, there are little data on how patients with reduced LVEF and LBBB respond to GDMT. Read More

    Myocardial Inflammation Predicts Remodeling and Neuroinflammation After Myocardial Infarction.
    J Am Coll Cardiol 2018 Jan;71(3):263-275
    Department of Nuclear Medicine, Hannover Medical School, Hannover, Germany. Electronic address:
    Background: The local inflammatory tissue response after acute myocardial infarction (MI) determines subsequent healing. Systemic interaction may induce neuroinflammation as a precursor to neurodegeneration.

    Objectives: This study sought to assess the influence of MI on cardiac and brain inflammation using noninvasive positron emission tomography (PET) of the heart-brain axis. Read More

    Dose-Dependent Cardioprotection of Moderate (32°C) Versus Mild (35°C) Therapeutic Hypothermia in Porcine Acute Myocardial Infarction.
    JACC Cardiovasc Interv 2018 Jan;11(2):195-205
    Division of Cardiovascular Medicine, Stanford University, Stanford, California; Cardiovascular Institute, Stanford University, Stanford, California.
    Objectives: The study investigated whether a dose response exists between myocardial salvage and the depth of therapeutic hypothermia.

    Background: Cardiac protection from mild hypothermia during acute myocardial infarction (AMI) has yielded equivocal clinical trial results. Rapid, deeper hypothermia may improve myocardial salvage. Read More

    Blood lactate is a predictor of short-term mortality in patients with myocardial infarction complicated by heart failure but without cardiogenic shock.
    BMC Cardiovasc Disord 2018 Jan 18;18(1). Epub 2018 Jan 18.
    Department of Cardiology, Clinical Sciences, Lund University and Skåne University Hospital, SE-221 81, Lund, Sweden.
    Background: Mortality in patients with acute myocardial infarction (AMI) has improved substantially with modern therapy including percutaneous coronary interventions (PCI) but remains high in certain subgroups such as patients presenting with overt cardiogenic shock. However, the risk for AMI in patients presenting acutely with signs of heart failure but without cardiogenic shock is less well described. We aimed to identify risk factors for mortality in AMI patients with heart failure without overt cardiogenic shock. Read More

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