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J Nucl Cardiol 2018 Dec 13. Epub 2018 Dec 13.

Turku PET Centre, University of Turku, 20520, Turku, Finland.

Background: Activation of glucagon-like peptide-1 receptor (GLP-1R) signaling protects against cardiac dysfunction and remodeling after myocardial infarction (MI). The aim of the study was to evaluate Ga-NODAGA-exendin-4 positron emission tomography (PET) for assessment of GLP-1R expression after MI in rats.

Methods And Results: Rats were studied at 3 days, 1 and 12 weeks after permanent coronary ligation or a sham-operation. Read More

J Nucl Cardiol 2018 Dec 13. Epub 2018 Dec 13.

Department of Nuclear Medicine, Post Graduate Institute of Medical Education and Research, Sector-12, Chandigarh, 160012, India.

Eur Radiol 2018 Dec 13. Epub 2018 Dec 13.

University Clinic of Internal Medicine III, Cardiology and Angiology, Medical University of Innsbruck, Anichstrasse 35, A-6020, Innsbruck, Austria.

Objectives: Cardiac magnetic resonance (CMR) is the gold-standard modality for the assessment of left ventricular (LV) remodeling in ST-elevation myocardial infarction (STEMI) patients. However, the commonly used remodeling criteria have never been validated for hard clinical events. We therefore aimed to define clear CMR criteria of LV remodeling following STEMI with proven prognostic impact. Read More

eNeurologicalSci 2018 Dec 22;13:46-48. Epub 2018 Nov 22.

Krankenanstalt Rudolfstiftung, Juchgasse 25, A-1030 Wien, Austria.

Takotsubo syndrome (TTS) is a transient transient left ventricular dysfunction, predominantly affecting elderly women and often preceded by emotional or physical stress. TTS may be the cause as well as the consequence of stroke. We report a 82-years old female with a history of long-standing untreated arterial hypertension who was hospitalized because of a left-sided tongue paralysis and dysarthria. Read More

J Clin Imaging Sci 2018 15;8:51. Epub 2018 Nov 15.

Department of Nuclear Medicine, CHU de Caen, Caen, France.

Objective: We evaluated the relative performances of dipyridamole (Dip) and regadenoson (Reg) in a cohort of patients referred for coronary artery disease diagnosis or follow-up using myocardial perfusion imaging.

Materials And Methods: We retrospectively included 515 consecutive patients referred for Tc-sestamibi myocardial perfusion single-photon emission computerized tomography (SPECT) on a cadmium-zinc-telluride (CZT) camera after pharmacologic stress. About three quarters ( = 391, 76%) received Dip. Read More

Mol Clin Oncol 2018 Dec 5;9(6):617-621. Epub 2018 Oct 5.

Department of Radiology, Shengjing Hospital of China Medical University, Shenyang, Liaoning 110004, P.R. China.

A cardiac lipoma and a cardiac liposarcoma are very uncommon conditions; however, the simultaneous development of the two is extremely rare. In addition, the symptoms of these conditions are not evident in the vast majority of cases, making them easily missed during diagnosis. The present case report describes a case of well-differentiated cardiac liposarcoma with a concomitant myocardial lipoma that was misdiagnosed as multiple cardiac lipomas. Read More

Biomed Rep 2018 Dec 12;9(6):540-544. Epub 2018 Oct 12.

Department of Clinical Pharmacy, The Third Hospital of Mianyang (Sichuan Mental Health Center), Mianyang, Sichuan 621000, P.R. China.

Paclitaxel (PTX) is an antimicrotubule agent, and is effective in treating a wide range of solid tumors. However, its use may lead to cardiovascular toxicities, the manifestations of which include arrhythmia, heart failure, acute myocardial ischemia and atrial fibrillation (AF). AF is among the severe reactions to the PTX cardiotoxicity, and a cause for substantial morbidity and mortality. Read More

Exp Ther Med 2018 Dec 1;16(6):4471-4478. Epub 2018 Oct 1.

Department of Critical Care Medicine, The Second Hospital of Lanzhou University, Lanzhou, Gansu 730000, P.R. China.

The aim of the present study was to investigate the role of plasmacytoma variant translocation gene 1 (PVT1) in the occurrence and development of sepsis-induced inflammation and cardiac dysfunction and its underlying mechanism. A sepsis rat model was first established by cecal ligation and puncture. The mRNA levels of PVT1 and microRNA-143 in the myocardial tissues of rats were detected by reverse transcription-quantitative polymerase chain reaction (RT-qPCR) analysis. Read More

Front Endocrinol (Lausanne) 2018 28;9:718. Epub 2018 Nov 28.

Endocrine, Cardiovascular and Metabolic Research, Unit for Multidisciplinary Research in Biomedicine, University of Porto, Porto, Portugal.

Obesity and obesity related co-morbidities are well-recognized risks for cardiovascular (CV) disease and mortality. Weight loss improves CV risk factors and the efficacy of bariatric surgery in decreasing CV mortality is now well-established. Our aim was to assess CV risk progression and occurrence of CV events in a cohort of patients that underwent Roux-en-Y gastric bypass (RYGB) for obesity treatment in a single academic public center. Read More

Biomark Insights 2018 29;13:1177271918812467. Epub 2018 Nov 29.

School of Life Sciences and Centre for Health Technologies, University of Technology Sydney, Broadway, NSW, Australia.

Atherosclerosis is the underlying cause of most myocardial infarction (MI) and ischaemic stroke episodes. An early sign of atherosclerosis is hypertrophy of the arterial wall. It is known that increased intima media thickness (IMT) is a non-invasive marker of arterial wall alteration, which can easily be assessed in the carotid arteries by high-resolution B-mode ultrasound. Read More

Sci Rep 2018 Dec 13;8(1):17829. Epub 2018 Dec 13.

Guangdong Cardiovascular Institute, Guangdong General Hospital, Guangdong Academy of Medical Science, Guangzhou, 510080, China.

Precise prevalence of atrial fibrillation (AF) and the associated risk factors in southern China are rarely reported. This large population-based follow-up study, the Guangzhou Heart Study, was conducted from 2015 to 2017 to fill up this gap. Permanent residents aged 35 years and above in Guangzhou city were enrolled and demographic factors of participants were collected by a structured questionnaire. Read More

EBioMedicine 2018 Dec 10. Epub 2018 Dec 10.

Department of Cardiology, State Key Laboratory of Organ Failure Research, Nanfang Hospital, Southern Medical University, Guangzhou, China.. Electronic address:

Background: We previously found that loss of lncRNA-AZIN2 splice variant (AZIN2-sv) increases cardiomyocyte (CM) proliferation and attenuates adverse ventricular remodelling post-myocardial infarction (MI). However, whether inhibition of AZIN2-sv can simultaneously induce angiogenesis and thus improve prognosis after MI is unclear.

Methods: We used in situ hybridization and quantitative PCR to determine AZIN2-sv expression in endothelial cells. Read More

Am J Kidney Dis 2018 Dec 10. Epub 2018 Dec 10.

Division of Kidney Diseases and Hypertension, George Washington University, Washington, DC. Electronic address:

Rationale & Objective: Traditional risk estimates for atherosclerotic vascular disease (ASVD) and death may not perform optimally in the setting of chronic kidney disease (CKD). We sought to determine whether the addition of measures of inflammation and kidney function to traditional estimation tools improves prediction of these events in a diverse cohort of patients with CKD.

Study Design: Observational cohort study. Read More

Am J Med Sci 2018 Nov 10. Epub 2018 Nov 10.

Department of Internal Medicine, Ascension Health, Saint John Hospital and Medical Center, Grosse Pointe Woods, Michigan.

Coronary embolism (CE) is an uncommon and unique cause of acute myocardial infarction. In this report, we review 216 cases of CE including 2 new cases from our institution. The mean patient age was 52. Read More

Int J Cardiol 2018 Dec 3. Epub 2018 Dec 3.

Cardiovascular Research Institute Basel (CRIB) and Department of Cardiology, University Hospital Basel, University of Basel, Switzerland; GREAT network. Electronic address:

Background: The clinical availability of high-sensitivity cardiac troponin (hs-cTn) has enabled the development of several innovative strategies for the rapid rule-out of acute myocardial infarction (AMI). Due to the lack of direct comparisons, selection of the best strategy for clinical practice is challenging.

Methods: In a prospective international multicenter diagnostic study enrolling 3696 patients presenting with suspected AMI to the emergency department, we compared the safety and efficacy of 14 different hs-cTn-based strategies: hs-cTn concentrations below the limit of detection (LoD), dual-marker combining hs-cTn with copeptin, ESC 0 h/1 h-algorithm, 0 h/2 h-algorithm, 2 h-ADP-algorithm, NICE-algorithm, and ESC 0 h/3 h-algorithm, each using either hs-cTnT or hs-cTnI. Read More

Am J Cardiol 2018 Dec 4. Epub 2018 Dec 4.

Serviço de Cardiologia e Cirurgia Cardiovascular e Centro de Telessaúde do Hospital das Clínicas da UFMG, Belo Horizonte, Minas Gerais, Brazil; Departamento de Clínica Médica, Faculdade de Medicina da Universidade Federal de Minas Gerais, Belo Horizonte, Minas Gerais, Brazil. Electronic address:

Incidence of Yellow Fever (YF) has increased in Brazil, and cardiac findings such as bradyarrhythmias and conduction abnormalities have been described. We aimed to perform a comprehensive cardiac evaluation of patients with YF, and to assess the association between cardiac involvement and disease severity. Patients hospitalized with YF from February to March 2018 underwent clinical and laboratory evaluation, focused bedside echocardiography (GE Vivid IQ), electrocardiogram and, in case of alterations, 24-hours Holter. Read More

Am J Cardiol 2018 Nov 20. Epub 2018 Nov 20.

Department of Cardiovascular Medicine, Wayne State University, Detroit, Michigan.

The objective of this study was to evaluate the impact of heart failure (HF) etiology (ischemic cardiomyopathy [ICM] versus nonischemic cardiomyopathy) on in-hospital outcomes in patients undergoing left ventricular assist device (LVAD) placement using the Nationwide Inpatient Sample database. We identified patients who underwent LVAD placement from 2011 to 2014. The primary end point was the effect of ICM on in-hospital mortality. Read More

Am J Cardiol 2018 Oct 21. Epub 2018 Oct 21.

Division of Cardiovascular Medicine, Department of Internal Medicine, University of Michigan Medical Center, Ann Arbor, Michigan.

This study evaluated prehospital transport times and clinical outcomes after different reperfusion strategies for ST-elevation myocardial infarction in a real-world setting. We consecutively enrolled 27,205 patients who underwent percutaneous coronary intervention (PCI) for ST-elevation myocardial infarction in Michigan from 2010 to 2016. Primary PCI was performed in 25,927 patients (95%), whereas 1,278 (5%) were treated with a pharmacoinvasive strategy. Read More

Am J Cardiol 2018 Dec 4. Epub 2018 Dec 4.

Department of Radiology, University of Ulsan College of Medicine, Asan Medical Center, Seoul, Korea. Electronic address:

Although decision-making for revascularization is based on the extent of ischemic myocardium, the prognostic implication of supplying myocardial territories has not yet been studied. To evaluate the clinical impact of the coronary artery-based myocardial segmentation (CAMS)-derived myocardial volume subtended to the poststenotic segment, and to determine clinically relevant coronary lesions, coronary computed tomography angiography, invasive coronary angiography, and preprocedure fractional flow reserve (FFR) data were analyzed in 664 deferred lesions (in 577 patients) and 401 treated lesions (in 369 patients) with drug-eluting stent implantation, respectively. Using CAMS method, the myocardial volume subtended to a stenotic coronary segment (V) was assessed. Read More

J Am Coll Cardiol 2018 Dec;72(24):3158-3176

Heidelberg University Hospital, Heidelberg, Germany; Department of Cardiology, McGill University Health Centre, Montreal, Canada; Department of Diagnostic Radiology, McGill University Health Centre, Montreal, Canada. Electronic address:

This JACC Scientific Expert Panel provides consensus recommendations for an update of the cardiovascular magnetic resonance (CMR) diagnostic criteria for myocardial inflammation in patients with suspected acute or active myocardial inflammation (Lake Louise Criteria) that include options to use parametric mapping techniques. While each parameter may indicate myocardial inflammation, the authors propose that CMR provides strong evidence for myocardial inflammation, with increasing specificity, if the CMR scan demonstrates the combination of myocardial edema with other CMR markers of inflammatory myocardial injury. This is based on at least one T2-based criterion (global or regional increase of myocardial T2 relaxation time or an increased signal intensity in T2-weighted CMR images), with at least one T1-based criterion (increased myocardial T1, extracellular volume, or late gadolinium enhancement). Read More

J Am Coll Cardiol 2018 Dec;72(24):3087-3094

Department of Kardiologie, Klinikum Würzburg Mitte, Standort Juliusspital, Würzburg, Germany; Medizinische Klinik 1, Leopoldina-Krankenhaus, Schweinfurt, Germany. Electronic address:

Background: Alcohol-induced infarction for treatment of symptomatic hypertrophic obstructive cardiomyopathy (HOCM) was discussed as a risk factor for increased cardiac mortality during follow-up.

Objectives: This study sought to report on long-term survival after echo-guided alcohol septal ablation (percutaneous transluminal septal myocardial ablation [PTSMA]) in symptomatic patients with HOCM.

Methods: Between May 2000 and June 2017, PTSMA with alcohol injection was performed in 952 patients (age 55. Read More

Cardiovasc Ultrasound 2018 Dec 13;16(1):32. Epub 2018 Dec 13.

Department of Echocardiography, Qingdao University Affiliated Hospital, No. 16 Jiangsu Road, Qingdao, 266001, China.

Background And Objectives: This study aimed to assess the changes of RA function in patients with obstructive sleep apnea syndrome (OSAS) using velocity vector imaging (VVI) and to evaluate the application of VVI technology.

Methods: According to the apnea-hypopnea index (AHI), 71 patients with OSAS were divided into three groups: mild, moderate, and severe. A total of 30 cases of healthy subjects were enrolled as the control group. Read More

Cardiovasc Diabetol 2018 Dec 13;17(1):157. Epub 2018 Dec 13.

Cardiology Division, Pontifical Catholic University of Campinas Medicine School, Rua Engenheiro Carlos Stevenson 560, Campinas, Sao Paulo, 13092-132, Brazil.

Patients with type 2 diabetes (T2DM) have a substantial risk of developing cardiovascular disease. The strong connection between the severity of hyperglycaemia, metabolic changes secondary to T2DM and vascular damage increases the risk of macrovascular complications. There is a challenging demand for the development of drugs that control hyperglycaemia and influence other metabolic risk factors to improve cardiovascular outcomes such as cardiovascular death, nonfatal myocardial infarction, nonfatal stroke, hospitalization for unstable angina and heart failure (major adverse cardiovascular events). Read More

BMC Cardiovasc Disord 2018 Dec 13;18(1):235. Epub 2018 Dec 13.

Central Hospital of Augsburg, MONICA/KORA Myocardial Infarction Registry, Augsburg, Germany.

Background: Sleep-related investigations in acute myocardial infarction (AMI) patients are rare. The aim of this study was to examine sex-specific associations of patient-reported sleep disturbances within 4 weeks before AMI and long-term survival.

Methods: From a German population-based, regional AMI registry, 2511 men and 828 women, aged 28-74 years, hospitalized with a first-time AMI between 2000 and 2008 and still alive after 28 days, were included in the study (end of follow-up: 12/2011). Read More

Circ Cardiovasc Interv 2018 Dec;11(12):e006752

Department of Adult Cardiology, Deutsches Herzzentrum München, Technische Universität, Munich, Germany (G.N., S.K., J.H., K.M., R.A.B., A.K.).

Background: The magnitude of prognostically relevant myocardial injury after percutaneous coronary interventions remains poorly defined. The Society for Cardiovascular Angiography and Interventions (SCAI) proposed marked biomarker elevations to define periprocedural myocardial infarction (PMI). These consensus-based thresholds have not been validated in the era of high-sensitivity cardiac troponins. Read More

Circ Cardiovasc Interv 2018 Dec;11(12):e006837

Department of Clinical Epidemiology and Biostatistics, University of Ulsan College of Medicine, Asan Medical Center, Seoul, South Korea (S.-C.Y.).

Background: Dual antiplatelet therapy (DAPT) helps prevent ischemic events after coronary stenting but comes with an increased risk of bleeding. Several risk scores have been proposed for the management of patients receiving DAPT, but no standardized tool exists for the purpose. We sought to compare the performance of the new PRECISE-DAPT (Predicting Bleeding Complication in Patients Undergoing Stent Implantation and Subsequent Dual Antiplatelet Therapy), CRUSADE (Can Rapid Risk Stratification of Unstable Angina Patients Suppress Adverse Outcomes with Early Implementation of the American College of Cardiology/American Heart Association Guidelines), and ACUITY (Acute Catheterization and Urgent Intervention Triage Strategy) scores for the prediction of bleeding in Korean patients receiving DAPT. Read More

Noncoding RNA 2018 Dec 12;4(4). Epub 2018 Dec 12.

Department of Biochemistry & Molecular Genetics, University of Louisville School of Medicine, Louisville, KY 40292, USA.

Non-coding RNAs (ncRNAs) are regulators of intracellular and intercellular signaling in breast cancer. ncRNAs modulate intracellular signaling to control diverse cellular processes, including levels and activity of estrogen receptor α (ERα), proliferation, invasion, migration, apoptosis, and stemness. In addition, ncRNAs can be packaged into exosomes to provide intercellular communication by the transmission of microRNAs (miRNAs) and long non-coding RNAs (lncRNAs) to cells locally or systemically. Read More

Medicine (Baltimore) 2018 Dec;97(49):e13582

Department of Critical Care Medicine, Suzhou Kowloon Hospital, Shanghai Jiao Tong University School of Medicine, Suzhou, China.

Rationale: The Epstein-Barr (EB) virus has rarely been reported as a cause of fulminant myocarditis. To our knowledge, the present case is the first report on myocardial calcification in EB viral myocarditis and rhabdomyolysis.

Patient Concerns: A 17-year-old man was admitted to the department with fever, chest tightness, and tachypnea that had been present for 2 days. Read More

Medicine (Baltimore) 2018 Dec;97(49):e13561

Department of Cardiology.

Rationale: The lambda-like ST-elevation electrocardiography (ECG) pattern is extremely rare in patients with type 2 myocardial infarction (T2MI) triggered by coronary spasm. When this ECG pattern appears, sudden cardiac death (SCD) caused by lethal ventricular arrhythmia may occur because clinicians do not pay sufficient attention to this phenomenon.

Patient Concerns: We describe a 41-year-old man who presented with steep down-sloping ST-segment elevation, paroxysmal ventricular tachycardia, severe sinus bradycardia, and intermittent complete atrioventricular block on ECG during the sudden recurrence of clinical symptoms. Read More

Medicine (Baltimore) 2018 Dec;97(49):e13512

Department of Neurology, Jiangxi Provincial People's Hospital.

Background: Lots of previous reports have suggested a potential association of atopic dermatitis (AD) with stroke and myocardial infarction (MI). However, the result is still controversial, Consequently, we conducted this meta-analysis to estimate the relationship of AD with Stroke and MI.

Methods: PubMed, Embase, and Web of Science databases were searched from inception to June 2018. Read More

Cardiovasc Res 2018 Dec 13. Epub 2018 Dec 13.

Department of Surgery, Leiden University Medical Center, the Netherlands.

Aims: We have shown that 14q32 microRNAs are highly involved in vascular remodeling and cardiovascular disease. However, the 14q32 locus also encodes 41 'orphan' small nucleolar RNAs (snoRNAs). We aimed to gather evidence for an independent role for 14q32 snoRNAs in human cardiovascular disease. Read More

Eur J Cardiothorac Surg 2018 Dec 12. Epub 2018 Dec 12.

Faculty of Health Sciences, Bristol Heart Institute, The Bristol Medical School, University of Bristol, Bristol, UK.

Objectives: This trial was designed and patients were recruited at a time when the benefits of remote ischaemic preconditioning during open-heart surgery were still controversial. We focused on a homogeneous patient population undergoing either isolated aortic valve replacement or coronary artery bypass grafting (CABG) surgery by investigating cardiac injury, metabolic stress and inflammatory response.

Methods: A 2-centre randomized controlled trial recruited a total of 124 patients between February 2013 and April 2015. Read More

Cardiorenal Med 2018 Dec 13;9(2):83-91. Epub 2018 Dec 13.

Department of Medicine, Einstein Medical Center, Philadelphia, Pennsylvania, USA.

Background: Renal dysfunction is an important predictor of poor outcomes in patients with heart failure with preserved ejection fraction (HFpEF). Right ventricular (RV) dysfunction is implicated as one of the explanations for worsening renal function in cardiorenal syndrome. Novel right heart catheterization (RHC) parameters such as pulmonary artery pulsatility index (PAPi) and right atrial to pulmonary capillary wedge pressure ratio (RA:PCWP) have been found as predictors of RV dysfunction. Read More

Am Heart J 2018 Nov 13;208:47-54. Epub 2018 Nov 13.

Cardiology, Department of Medicine, University of Miami Miller School of Medicine, Miami, FL 33136, USA. Electronic address:

Importance: Most individuals who die of sudden cardiac death (SCD) display very advanced lesions of atherosclerosis in their coronary arteries. Thus, we sought to identify and characterize a putative subpopulation of young individuals exhibiting accelerated coronary artery atherosclerosis.

Objective: Our analysis of the Pathobiological Determinants of Atherosclerosis in Youth (PDAY) study-which examined 2651 individuals, obtaining quantitative measurements of traditional risk factors for coronary heart disease (CHD)-aimed to identify individuals with advanced coronary artery lesions, and to determine whether risk factors could account for such rapid disease progression, or not. Read More

Chest 2018 Dec 10. Epub 2018 Dec 10.

'Cava de' Tirreni and Amalfi Coast' Hospital, Division of Cardiology, Heart Department, University Hospital, Salerno, Italy.

Background: The most important determinant of long term survival in idiopathic pulmonary fibrosis (IPF) patients is the adaptation of the right ventricle (RV) to the increased pulmonary vascular resistance. Our aim was to explore RV contractile reserve during stress echocardiography (SE) in early stage IPF.

Methods: 50 early stage IPF patients and 50 healthy controls underwent rest and SE, including RV 2-dimensional Speckle Tracking Echocardiography (2DSTE). Read More

PLoS One 2018 13;13(12):e0208842. Epub 2018 Dec 13.

Department of Medical Sciences, University of Ferrara, Ferrara, Italy.

Objectives: Return to work after acute myocardial infarction (AMI), a leading cause of death globally, is a multidimensional process influenced by clinical, psychological, social and occupational factors, the single impact of which, however, is still not well defined. The objective of this study was to investigate these 4 factors on return to work (RTW) within 365 days after AMI in a homogeneous cohort of patients who had undergone an urgent coronary angioplasty.

Participants: We studied 102 patients, in employment at the time of AMI (88. Read More

PLoS One 2018 13;13(12):e0208817. Epub 2018 Dec 13.

Division of Cardiology, Department of Internal Medicine, Hanyang University College of Medicine, Seoul, Republic of Korea.

Background: A biphasic, U-shape relationship has been reported between body mass index (BMI) and clinical outcomes following percutaneous coronary intervention (PCI). However, the relationship between waist circumference (WC) and the cardiovascular risk following PCI has not been reported.

Methods: A prospective cohort study was performed. Read More

Eur J Anaesthesiol 2018 Dec 12. Epub 2018 Dec 12.

From the Center for Surgical Science, Department of Surgery, Zealand University Hospital, Koege (SE, CG, IG), and Faculty of Health & Medical Sciences, University of Copenhagen, Frederiksberg, Denmark (AMVS-P, JL).

Background: Myocardial injury after noncardiac surgery is common and associated with major adverse cardiac events. Surgery induces acute endothelial dysfunction, which might be central in the pathophysiology of myocardial injury; however, the relationship between surgical stress and endothelial function remains incompletely understood.

Objectives: This study aimed to assess the acute peri-operative changes in endothelial function after minor elective abdominal surgery. Read More

A A Pract 2018 Dec 7. Epub 2018 Dec 7.

From the Department of Anaesthesia and Intensive Care, Postgraduate Institute of Medical Education and Research, Chandigarh, India.

Myocardial ischemia postarterial switch operation has been reported extensively in the literature and has been almost exclusively ascribed to issues related to coronary artery translocation. Here, we report a case of a 5-week-old child with D-transposition of the great arteries who underwent an arterial switch operation and developed myocardial ischemia after pericardial drain placement, as evidenced by significant ST segment elevation and abnormal regional cardiac wall motion. The ST segment and cardiac wall motion improved once the drain was withdrawn from the pericardium and placed in the retrosternal space. Read More

Acta Medica (Hradec Kralove) 2018 ;61(3):111-113

Department of Medicine E, Sheba Medical Center, Tel-Hashomer affiliated to Sackler Faculty of Medicine, Tel Aviv University, Israel.

Duodenal Switch procedure is a type of bariatric surgery that was reserved for severely morbid obese people. Patients undergoing this procedure are at high risk for nutrient deficiencies. In this report we present a case of a patient who had developed polyneuropathy, generalized muscle weakness, Wernicke encephalopathy, myocardial dysfunction and pericardial effusion six years following this operation. Read More

J Appl Physiol (1985) 2018 Dec 13. Epub 2018 Dec 13.

Department Medical Sciences and Public Health, University of Cagliari, Italy.

Metaboreflex is a reflex triggered during exercise or post-exercise muscle ischemia (PEMI) by metaboreceptor stimulation. Typical features of metaboreflex are increased cardiac output (CO) and blood pressure. Patients suffering from metabolic syndrome display hemodynamic abnormalities, with an exaggerated systemic vascular resistance (SVR) and reduced CO response during PEMI-induced metaboreflex. Read More

Hypertension 2019 Jan;73(1):102-111

From the Department of Cardiology and Angiology, Hannover Medical School, Germany (D.F., S.T., D.H.-K., P.G., J.B.).

Myocardial infarction (MI) is a major cause of death worldwide. Here, we identify the macrophage MR (mineralocorticoid receptor) as a crucial pathogenic player in cardiac wound repair after MI. Seven days after left coronary artery ligation, mice with myeloid cell-restricted MR deficiency compared with WT (wild type) controls displayed improved cardiac function and remodeling associated with enhanced infarct neovascularization and scar maturation. Read More

Anal Chem 2018 Dec 13. Epub 2018 Dec 13.

Myeloid-derived growth factor (MYDGF in humans, Mydgf in mice) is a secreted protein with previously unknown biological functions. In a recent study, Mydgf was shown to mediate cardiac repair after acute myocardial infarction (MI) in mice. Lack of a sensitive assay to measure MYDGF in the circulation has hampered its further investigation. Read More

ACS Appl Mater Interfaces 2018 Dec 13. Epub 2018 Dec 13.

Cardiac tissue engineering (CTE) remains a great challenge to construct a cell-inductive scaffold which has positive effects on cardiac cell behaviors and cardiac tissue repair. In this study, we for the first time demonstrated that Si ions evidently stimulated the expression of cardiac specific genes and proliferation of neonatal rat cardiomyocytes (NRCMs) at concentration ranges of 0.13 ~ 10. Read More

Turk J Med Sci 2018 12 12;48(6):1293-1301. Epub 2018 Dec 12.

Department of Physiology, Faculty of Medicine, Kocaeli University, Kocaeli, Turkey

Background/aim: Epileptic seizure leads to sudden unexpected death in epilepsy (SUDEP) among affected patients. The causes of SUDEP are still unclear. The aim of this study was to research the effect of epilepsy on myocardial injury and arrhythmias during experimentally induced acute myocardial ischemia. Read More

Cardiovasc Toxicol 2018 Dec 12. Epub 2018 Dec 12.

Department of Cardiology, The University of Texas MD Anderson Cancer Center, 1400 Pressler Street, 1451, 77030, Houston, TX, USA.

The use of vascular endothelial growth factor inhibitors such as sorafenib is limited by a risk of severe cardiovascular toxicity. A 28-year-old man with acute myeloid leukemia treated with prednisone, tacrolimus, and sorafenib following stem cell transplantation presented with severe bilateral lower extremity claudication. The patient was discharged against medical advice prior to finalizing a cardiovascular evaluation, but returned 1 week later with signs suggestive of septic shock. Read More

Hum Cell 2018 Dec 12. Epub 2018 Dec 12.

Department of Anesthesiology, Changzhou No.2 People's Hospital, The Affiliated Hospital of Nanjing Medical University, No. 29 Xinglong Road, Changzhou, 213000, Jiangsu, China.

Cardiomyocyte apoptosis plays an important role in ischemia/reperfusion (I/R)-induced myocardial injury. Autophagy is suggested to be widely implicated in regulating cell survival and death. The cardioprotection of sevoflurane postconditioning has been long recognized, but the underlying mechanisms are not well understood. Read More

Adv Exp Med Biol 2018 Dec 13. Epub 2018 Dec 13.

Wallace H. Coulter Department of Biomedical Engineering, Emory University and Georgia Institute of Technology, Atlanta, GA, USA.

The explosion of stem cell research in the past several years has made its presence known in the field of cardiology and has been recently tasked with solving one of the largest health problems to afflict humanity: cardiovascular disease (CVD). Although stem cell therapy has shown glimmers of promise, significant problems remain that need to be addressed if these therapies are to ever find true success. One way to achieve this success is to take engineering principles and apply them to fabricate engineered cardiac tissues, composed of the aforementioned therapeutic stem cells and biomaterials to bolster the tissue's reparative capacity. Read More

F1000Res 2018 27;7. Epub 2018 Nov 27.

Cardiovascular Research Center, Mount Sinai School of Medicine, New York, New York, USA.

Heart failure is a major cause of global morbidity and mortality. Acute myocardial infarction (AMI) is a primary cause of heart failure due in large part to residual myocardial damage despite timely reperfusion therapy. Since the 1970's, multiple preclinical laboratories have tested whether reducing myocardial oxygen demand with a mechanical support pump can reduce infarct size in AMI. Read More

Medchemcomm 2018 Nov 14;9(11):1831-1842. Epub 2018 Sep 14.

Therapeutics Platform , Broad Institute of MIT and Harvard , Cambridge , MA02142 , USA . Email: ; Tel: +1 617 714 7377.

Increased expression of the Tribbles pseudokinase 1 gene () is associated with lower plasma levels of LDL cholesterol and triglycerides, higher levels of HDL cholesterol and decreased risk of coronary artery disease and myocardial infarction. We identified a class of tricyclic glycal core-based compounds that upregulate expression in human HepG2 cells and phenocopy the effects of genetic overexpression as they inhibit expression of triglyceride synthesis genes and ApoB secretion in cells. In addition to predicted effects related to downregulation of VLDL assembly and secretion these compounds also have unexpected effects as they upregulate expression of LDLR and stimulate LDL uptake. Read More