2,854 results match your criteria Myeloid Sarcoma


A New Complex Karyotype Involving a KMT2A-r Variant Three-Way Translocation in a Rare Clinical Presentation of a Pediatric Patient with Acute Myeloid Leukemia.

Cytogenet Genome Res 2019 Apr 12. Epub 2019 Apr 12.

Patients with childhood acute myeloid leukemia (AML) with complex karyotypes (CKs) have a dismal outcome. However, for patients with a KMT2A rearrangement (KMT2A-r), the prognosis appears to depend on the fusion partner gene rather than the karyotype structure. Thus, a precise characterization of KMT2A-r and the fusion partner genes, especially in CKs, is of interest for managing AML. Read More

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https://www.karger.com/Article/FullText/499640
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http://dx.doi.org/10.1159/000499640DOI Listing
April 2019
3 Reads

Disseminated De Novo Myeloid Sarcoma in a 17-year-old Boy.

Pediatr Dermatol 2019 Apr 2. Epub 2019 Apr 2.

Section of Dermatology, Division of Paediatric Medicine, The Hospital for Sick Children, Toronto, Ontario, Canada.

Myeloid sarcoma (MS) is a rare extramedullary tumor of malignant myeloid cells often associated with acute myeloid leukemia. We report a case of a 17-year-old boy presenting with diffuse red-brown skin nodules ultimately diagnosed with the scarcely described disseminated, de novo MS. It is important for dermatologists to keep MS on their differential when assessing patients with disseminated red-brown nodules. Read More

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http://dx.doi.org/10.1111/pde.13824DOI Listing
April 2019
3 Reads

Isolated Intracranial Myeloid Sarcoma at Age 6 Months with Metastases : Case Report and Review of the Literature.

Clin Neuroradiol 2019 Apr 2. Epub 2019 Apr 2.

Department of Radiology, Zhujiang Hospital, Southern Medical University, 253 Gongye Middle Avenue, Haizhu District, 510282, Guangzhou, Guangdong, China.

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http://dx.doi.org/10.1007/s00062-019-00779-zDOI Listing
April 2019
2 Reads

Myeloid malignancies after treatment for solid tumours.

Best Pract Res Clin Haematol 2019 03 26;32(1):40-46. Epub 2019 Feb 26.

Division of Haematology and Oncology, Medical College of Wisconsin, Milwaukee, WI, USA. Electronic address:

The cure rate for several solid tumour malignancies including breast cancers, head and neck cancers, bone cancers, and sarcoma has improved remarkably with the advent of neoadjuvant and adjuvant therapies. Unfortunately, exposure to chemotherapy or radiation as a part of these treatments exposes patients to the risk of subsequent myeloid malignancies. Therapy related myeloid malignancies have certain characteristic findings. Read More

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http://dx.doi.org/10.1016/j.beha.2019.02.012DOI Listing
March 2019
2 Reads

Rare myeloid sarcoma with KMT2A (MLL)-ELL fusion presenting as a vaginal wall mass.

Diagn Pathol 2019 Mar 28;14(1):26. Epub 2019 Mar 28.

Department of Pathology, Northwestern University Feinberg School of Medicine, 303 East Chicago Avenue, ward 3-140, Chicago, IL, 60611, USA.

Backgroud: Myeloid sarcoma (MS) is a rare neoplasm of immature myeloid precursors that form tumor mass outside the bone marrow. The diagnosis of de novo MS can be challenging, particularly in patients with no prior history of hematologic malignancies or when MS involves unusual anatomic sites.

Case Presentation: The patient was a 53-year-old woman with a history of uterine fibroids and vaginal bleeding for many years who presented with a vaginal wall mass. Read More

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https://diagnosticpathology.biomedcentral.com/articles/10.11
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http://dx.doi.org/10.1186/s13000-019-0804-6DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6440110PMC
March 2019
3 Reads

Clinicopathologic and Molecular Characteristics of Extramedullary Acute Myeloid Leukemia.

Histopathology 2019 Mar 27. Epub 2019 Mar 27.

Department of Pathology, University of Alabama at Birmingham, Birmingham, AL, USA.

Aims: Myeloid sarcoma (MS) is a rare extramedullary neoplasm composed of immature myeloid precursor cells thought to be a unique clinical presentation of acute myeloid leukemia (AML). Like AML, MS has a poor prognosis but due to the rare nature of MS, there are limited studies examining potential prognostic factors. We report our institutional experience, with the aim of investigating and establishing salient clinicopathological and molecular features of MS. Read More

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https://onlinelibrary.wiley.com/doi/abs/10.1111/his.13864
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http://dx.doi.org/10.1111/his.13864DOI Listing
March 2019
3 Reads

Radiological and clinical patterns of myeloid sarcoma.

Radiol Oncol 2019 Mar 14. Epub 2019 Mar 14.

Department of Diagnostic and Interventional Radiology, University Hospital Leipzig, Leipzig, Germany.

Background Myeloid sarcoma (MS), also known as granulocytic sarcoma or chloroma, is a solid tumor of extramedullary localization composed of malignant primitive myeloid cells. The purpose of the study was to identify clinical and imaging features in a large patient sample. Patients and methods Overall, 71 cases (34 females (47. Read More

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http://dx.doi.org/10.2478/raon-2019-0014DOI Listing
March 2019
1 Read

An Unusual Cause of Epistaxis: Paranasal Sinus Myeloid Sarcoma.

Case Rep Hematol 2019 12;2019:1312630. Epub 2019 Feb 12.

Department of Otolaryngology Head and Neck Surgery, The University of Tennessee Health Sciences Center, Memphis, USA.

We report a case of a 65-year-old female who presented with right-sided headaches, blurring of vision in the right eye, cold-induced epistaxis, and facial numbness in the trigeminal nerve distribution. Laboratory studies revealed a significant number of myeloblasts on peripheral smear with granulated cytoplasm, irregular nuclei, and prominent vacuoles. Magnetic resonance imaging (MRI) of the brain demonstrated a T1-enhancing 1. Read More

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http://dx.doi.org/10.1155/2019/1312630DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6390259PMC
February 2019
3 Reads

Getting away with phase transition: NPM1-mutated bone myeloid sarcoma mimicking Ewing sarcoma.

Ann Hematol 2019 Mar 16. Epub 2019 Mar 16.

Institute of Haematology and Centre of Haemato-Oncology Research (CREO), University and Hospital of Perugia, Perugia, Italy.

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http://dx.doi.org/10.1007/s00277-019-03664-4DOI Listing
March 2019
1 Read

ISOLATED MEDIASTINAL MYELOID SARCOMA AFTER POSITIVE ACUTE MYELOID LEUKEMIA

Turk J Haematol 2019 Mar 12. Epub 2019 Mar 12.

Pediatric Hematologist, Department of Pediatric Hematology, Dokuz Eylül University Faculty of Medicine, Izmir, TURKEY

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http://dx.doi.org/10.4274/tjh.galenos.2019.2018.0434DOI Listing
March 2019
1 Read
0.340 Impact Factor

Acute promyelocytic leukemia presenting as recurrent spinal myeloid sarcomas 3 years before developing leukemia: A case report with review of literature.

Clin Case Rep 2019 Feb 8;7(2):316-321. Epub 2019 Jan 8.

Division of Blood Transfusion Japan Red Cross Musashino Hospital Tokyo Japan.

The de novo myeloid sarcoma (MS) type of acute promyelocytic leukemia (APL) is rare, and clinical features may differ from extramedullary diseases in advanced APL. Many cases occur as a spinal tumor, and some occur in the absence of bone-marrow diseases or coagulation abnormalities. Fluorescence in situ hybridization analysis of MS tissue is useful for accurate diagnosis, even in preserved tissue. Read More

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http://dx.doi.org/10.1002/ccr3.1991DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6389481PMC
February 2019
2 Reads

Myeloid Sarcoma.

Oncol Res Treat 2019 6;42(4):224-229. Epub 2019 Mar 6.

Department of Medical Oncology, National Cancer Institute, Cairo University, Cairo, Egypt.

Hematological malignancies can manifest as extramedullary soft tissue masses in relatively rare cases. The rarity of it causes a diagnostic and therapeutic challenge. One of the rarest manifestations is myeloid sarcoma (MS). Read More

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http://dx.doi.org/10.1159/000497210DOI Listing
March 2019
6 Reads

An Exceptional Vulvar Tumor: Myeloid Sarcoma of the Labia Majora.

Int J Gynecol Pathol 2019 Mar 1. Epub 2019 Mar 1.

Departments of Obstetrics and Gynecology (K.P.R., S.G.K.) Pathology (F.H.G., L.A.N.) Internal Medicine, Albert Schweitzer Hospital (M.D.L.), Dordrecht, The Netherlands.

Vulvar malignancies are rare and have diverse origins and presentations. The majority of these tumors are squamous cell carcinoma. An ulcerating vulvar tumor was found in a 74-yr-old woman presenting with fatigue and leukocytosis. Read More

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http://dx.doi.org/10.1097/PGP.0000000000000595DOI Listing
March 2019
4 Reads
1.631 Impact Factor

Prevalence of deaths in a cohort of girls and women with cryopreserved ovarian tissue.

Acta Obstet Gynecol Scand 2019 May 29;98(5):625-629. Epub 2019 Mar 29.

The Fertility Clinic, section 4071, University Hospital of Copenhagen Rigshospitalet, Copenhagen, Denmark.

Introduction: Ovarian tissue cryopreservation (OTC) is increasingly offered to women in need of fertility preservation. However, little is known about the risk of these women dying before they use the preserved material.

Material And Methods: From 1999 to 2016, 927 girls and women underwent OTC in our center, before receiving gonadotoxic treatment. Read More

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http://dx.doi.org/10.1111/aogs.13576DOI Listing
May 2019
1 Read

Evidence for an alternative fatty acid desaturation pathway increasing cancer plasticity.

Nature 2019 Feb 6;566(7744):403-406. Epub 2019 Feb 6.

Laboratory of Cellular Metabolism and Metabolic Regulation, VIB-KU Leuven Center for Cancer Biology, VIB, Leuven, Belgium.

Most tumours have an aberrantly activated lipid metabolism that enables them to synthesize, elongate and desaturate fatty acids to support proliferation. However, only particular subsets of cancer cells are sensitive to approaches that target fatty acid metabolism and, in particular, fatty acid desaturation. This suggests that many cancer cells contain an unexplored plasticity in their fatty acid metabolism. Read More

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http://dx.doi.org/10.1038/s41586-019-0904-1DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6390935PMC
February 2019
14 Reads

Acute leukemias harboring KMT2A/MLLT10 fusion: a 10-year experience from a single genomics laboratory.

Genes Chromosomes Cancer 2019 Feb 1. Epub 2019 Feb 1.

Division of Laboratory Genetics and Genomics, Department of Laboratory Medicine and Pathology, Mayo Clinic, Rochester, Minnesota.

The MLLT10 (formerly AF10) gene is the fourth most common KMT2A fusion partner across all acute leukemias and requires at least 3 breaks to form an in-frame KMT2A/MLLT10 fusion due to the opposite orientation of each gene. A 10-year retrospective review was performed to identify individuals from all age groups that harbor KMT2A/MLLT10 fusion obtained by our KMT2A/MLLT10 dual-color dual-fusion fluorescence in situ hybridization (D-FISH) assay. Of the 60 unique individuals identified, 31 were male and 29 were female (M:F ratio, 1. Read More

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http://dx.doi.org/10.1002/gcc.22741DOI Listing
February 2019
2 Reads

A complex mutational profile and a distinct clonal evolution during NPM1 myeloid sarcoma.

Leuk Lymphoma 2019 Feb 1:1-3. Epub 2019 Feb 1.

b Laboratory of Hematology - Molecular Biology , University Hospital of Saint-Etienne , Saint-Etienne , France.

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http://dx.doi.org/10.1080/10428194.2019.1571199DOI Listing
February 2019
1 Read

Second primary cancers in patients with acute lymphoblastic, chronic lymphocytic and hairy cell leukaemia.

Br J Haematol 2019 Apr 31;185(2):232-239. Epub 2019 Jan 31.

Division of Molecular Genetic Epidemiology, German Cancer Research Centre (DKFZ), Heidelberg, Germany.

Improvement of survival in lymphocytic leukaemia has been accompanied by the occurrence of second primary cancer (SPCs). Based on Swedish Family Cancer Database, we applied bi-directional analyses in which relative risks (RRs) were calculated for any SPCs in patients with chronic lymphocytic leukaemia (CLL), acute lymphoblastic leukaemia (ALL) and hairy cell leukaemia (HCL) and the risks of these leukaemias as SPCs. After CLL, RRs were significant for 20 SPCs, and high for skin squamous cell cancer (24·58 for in situ and 7·63 for invasive), Merkel cell carcinoma (14·36), Hodgkin lymphoma (7·16) and Kaposi sarcoma (6·76). Read More

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http://dx.doi.org/10.1111/bjh.15777DOI Listing
April 2019
4 Reads

Myeloid Sarcoma with Megakaryoblastic Differentiation Arising in the Conjunctiva.

Ocul Oncol Pathol 2019 Jan 22;5(1):28-35. Epub 2018 May 22.

Eyelid Experts, Palm Beach Gardens, Florida, USA.

An 87-year-old woman not known to have either a lymphoma or leukemia developed a left multinodular, fish-flesh superior epibulbar and forniceal mass. A biopsy disclosed a blastic tumor with scattered multinucleated immature megakaryoblasts. Immunophenotyping of bone marrow cells revealed strong positivity for CD7, CD31, CD43, CD45, CD61, and CD117; CD71, myeloperoxidase, and lysozyme were also positive in scattered cells. Read More

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https://www.karger.com/Article/FullText/488057
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http://dx.doi.org/10.1159/000488057DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6341420PMC
January 2019
12 Reads

Using the Spleen as an Systemic Immune Barometer Alongside Osteosarcoma Disease Progression and Immunotherapy with -PD-L1.

Sarcoma 2018 12;2018:8694397. Epub 2018 Dec 12.

Department of Orthopaedics, West Virginia University, Morgantown, WV, USA.

Indications for immunotherapies are still unclear, and there is a great need for real-time patient immune status monitoring. In this study, we confirmed that the local and systemic immune profiles of an orthotopic osteosarcoma model with or without luciferase transfection were statistically equivalent. Next, we used flow cytometry to describe systemic immune cell populations influenced by osteosarcoma disease progression. Read More

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https://www.hindawi.com/journals/sarcoma/2018/8694397/
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http://dx.doi.org/10.1155/2018/8694397DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6311869PMC
December 2018
11 Reads

Remarks on Myeloid Sarcoma in Children

Authors:

Turk J Haematol 2019 Jan 17. Epub 2019 Jan 17.

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http://dx.doi.org/10.4274/tjh.2019.0002DOI Listing
January 2019
2 Reads

Heart failure due to cardiac myeloid sarcoma.

Eur Heart J Cardiovasc Imaging 2019 Jan 10. Epub 2019 Jan 10.

University Clinic of Internal Medicine III, Cardiology and Angiology, Medical University of Innsbruck, Anichstrasse 35, Innsbruck, Austria.

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http://dx.doi.org/10.1093/ehjci/jey226DOI Listing
January 2019
5 Reads

Myeloid sarcoma presenting as an unusual limbal mass.

BMJ Case Rep 2019 Jan 14;12(1). Epub 2019 Jan 14.

Department of Medical Oncology, Institute Rotary Cancer Hospital, All India Institute of Medical Sciences, New Delhi, New Delhi, India.

A 19-year-old woman presented to the outpatient department with occasional ocular pain and redness and a perilimbal mass, which she noticed 5 months ago in her left eye. She had no systemic complaints. Ultrasound biomicroscopy of the mass showed a hypoechoic lesion with uniform reflectivity. Read More

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http://casereports.bmj.com/lookup/doi/10.1136/bcr-2018-22628
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http://dx.doi.org/10.1136/bcr-2018-226284DOI Listing
January 2019
9 Reads

Effect of Neutropenic Diet on Infection Rates in Cancer Patients With Neutropenia: A Meta-analysis of Randomized Controlled Trials.

Am J Clin Oncol 2019 Mar;42(3):270-274

Sidney Kimmel Comprehensive Cancer Center, Johns Hopkins University, Baltimore MD.

Introduction: Neutropenic diets are commonly prescribed to cancer patients with neutropenia with the intention of reducing rates of infection. These diets are restrictive and are associated with lower patient satisfaction and possibly malnutrition. Further, it is unclear if these restrictive diets are effective in reducing infection. Read More

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http://dx.doi.org/10.1097/COC.0000000000000514DOI Listing
March 2019
29 Reads

Co-Occurrence of Myeloid Sarcoma of the Lymph Node and Acute Monocytic Myeloid Leukemia: A Case Report and Literature Review.

Case Rep Oncol 2018 Sep-Dec;11(3):791-799. Epub 2018 Nov 29.

Division of Hematology and Oncology, Bronx Care Health System, Affiliated with Icahn School of Medicine at Mount Sinai, Bronx, New York, USA.

Background: Acute myeloid leukemia (AML) is the most common leukemia in adults. According to the French-American-British (FAB) system, monocytic leukemia is classified as M5. Myeloid sarcoma further occurs in 3-5% of AML. Read More

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http://dx.doi.org/10.1159/000494830DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6323399PMC
November 2018
4 Reads

Primary Vaginal Chloroma: A Rare Case Report.

Int J Hematol Oncol Stem Cell Res 2018 Jul;12(3):166-168

Department of Medical and Paediatric Oncology, Gujarat Cancer and Research Institute, Ahmedabad, Gujarat, India.

Chloroma (granulocytic sarcoma or myeloid sarcoma) is a rare malignant extra-medullary neoplasm of myeloid precursor cells. It is usually associated with myeloproliferative disorders but very rarely may precede the onset of leukaemia. Here we are presenting a rare case of chloroma in a female patient without initial presentation of AML. Read More

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http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6305264PMC
July 2018
3 Reads

A case of primary cutaneous Ewing sarcoma in a neutropenic patient.

J Cutan Pathol 2019 Mar 16;46(3):238-241. Epub 2019 Jan 16.

Department of Dermatology, University of Iowa Hospitals and Clinics, Iowa City, Iowa.

Primary cutaneous Ewing sarcoma is a rare clinical presentation of Ewing sarcoma, usually occurring as a small, localized tumor on the extremities of young adults and associated with favorable prognosis. We report a case of primary cutaneous Ewing sarcoma, which presented on the sole of the foot of a 27-year-old patient with relapsed acute myeloid leukemia and neutropenia. Diagnosis was determined through histological features and staining, as well as fluorescence in situ hybridization and molecular testing. Read More

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http://dx.doi.org/10.1111/cup.13406DOI Listing
March 2019
6 Reads

Male with myelofibrosis and ulceronecrotic lesions.

Rev Assoc Med Bras (1992) 2018 Dec;64(12):1073-1074

Department of Internal Medicine, São Francisco Hospital, Ribeirão Preto, SP, Brasil.

Objective: Granulocytic sarcoma also called myeloid sarcoma is an extramedullary tumour of immature granulocytic cells. It is a rare entity, and mostly accompanied by acute myeloid leukaemia. It is observed during the course of myeloproliferative disorders especially in chronic myeloid leukaemia and myelodysplastic syndromes. Read More

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http://dx.doi.org/10.1590/1806-9282.64.12.1073DOI Listing
December 2018
3 Reads

A Lateral Neck Myeloid Sarcoma Presenting as Acute Otitis Externa.

Arch Iran Med 2018 Nov 1;21(11):544-546. Epub 2018 Nov 1.

Iranian Research Center for HIV/AIDS (IRCHA), Tehran University of Medical Sciences, Tehran, Iran.

Myeloid sarcoma (MS) is a solid extra-medullary tumor of immature myeloid cells which could occur before, during or after remission of acute leukemia at any site on the body. Owing to variation in differential diagnosis, pathologic evaluation and immunohistochemical staining are essential for definitive diagnosis. Rarely, MS has been shown as an isolated extramedullary relapse (iEMR) after allogeneic stem cell transplantation (allo-SCT), which often does not necessarily result in bone marrow involvement. Read More

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November 2018
2 Reads

[Myeloid Sarcoma of the Testis].

Hinyokika Kiyo 2018 Nov;64(11):459-463

The Department of Urology, Yokohama City Minato Red Cross Hospital.

A 68-year-old man with swelling of his left testis was referred to our hospital. There was no history of hematologic disease. The diameter of the testicular mass was 40 mm. Read More

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http://dx.doi.org/10.14989/ActaUrolJap_64_11_459DOI Listing
November 2018
1 Read

Successful Treatment of Relapsed Pediatric Acute Myeloid Leukemia Presenting as Central Nervous System Myeloid Sarcoma: A Single-Institution Case Series.

J Pediatr Hematol Oncol 2018 Dec 12. Epub 2018 Dec 12.

Department of Pediatric Hematology-Oncology, University of Louisville, Louisville, KY.

Relapsed acute myeloid leukemia presenting as an isolated central nervous system myeloid sarcoma (CNS MS) is very rare and generally entails poor outcomes. CNS MS treatment is not well defined and can include systemic chemotherapy, intrathecal chemotherapy, radiation therapy, or hematopoietic stem cell transplant. Thiotepa, vinorelbine, topotecan, and clofarabine (TVTC) has been successful for reinduction therapy in relapsed/refractory leukemia to induce remission before hematopoietic stem cell transplant. Read More

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http://dx.doi.org/10.1097/MPH.0000000000001383DOI Listing
December 2018
11 Reads

Myelolytic Treatments Enhance Oncolytic Herpes Virotherapy in Models of Ewing Sarcoma by Modulating the Immune Microenvironment.

Mol Ther Oncolytics 2018 Dec 18;11:62-74. Epub 2018 Oct 18.

Center for Childhood Cancer and Blood Diseases, Nationwide Children's Hospital, The Ohio State University, Columbus, OH 43205, USA.

Ewing sarcoma is a highly aggressive cancer that promotes the infiltration and activation of pro-tumor M2-like macrophages. Oncolytic virotherapy that selectively infects and destroys cancer cells is a promising option for treating Ewing sarcoma. The effect of tumor macrophages on oncolytic virus therapy, however, is variable among solid tumors and is unknown in Ewing sarcoma. Read More

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http://dx.doi.org/10.1016/j.omto.2018.10.001DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6249791PMC
December 2018
4 Reads

A case of myeloid sarcoma presenting with an orbital mass, hearing loss, and multiple cranial neuropathies.

Turk J Pediatr 2018 ;60(3):322-325

Department of Pediatrics, Gachon University, Gil Medical Center, Incheon, South Korea.

Lim SH, Nam HN, Lim KI, Jeon IS. A case of myeloid sarcoma presenting with an orbital mass, hearing loss, and multiple cranial neuropathies. Turk J Pediatr 2018; 60: 322-325. Read More

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http://dx.doi.org/10.24953/turkjped.2018.03.015DOI Listing
February 2019
5 Reads

Increased angiogenesis seems to correlate with inferior overall survival in myeloid sarcoma patients.

Pol J Pathol 2018;69(3):254-265

Myeloid sarcomas (MS) are tumors composed by myeloid elements and developing outside bone marrow. The prognosis is overall poor, only stem cell transplantation being consistently reposted as a potentially curative approach. In this study we explored whether microvessel density, a biomarker of angiogenesis, might be relevant in MS. Read More

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http://dx.doi.org/10.5114/pjp.2018.79545DOI Listing
January 2018
2 Reads

Predictors of Discharge Disposition Following Laminectomy for Intradural Extramedullary Spinal Tumors.

World Neurosurg 2019 Mar 27;123:e427-e432. Epub 2018 Nov 27.

Department of Orthopaedic Surgery, Icahn School of Medicine at Mount Sinai, New York, New York, USA. Electronic address:

Objective: To identify independent risk factors for non-home discharge in patients undergoing laminectomy for intradural extramedullary spinal tumors.

Methods: We performed a retrospective cohort analysis of data from the American College of Surgeons National Surgical Quality Improvement Program from 2011 to 2014. Adult patients who underwent laminectomy for the excision of intradural extramedullary spinal tumors were included and divided into 2 groups based on home or non-home discharge disposition. Read More

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http://dx.doi.org/10.1016/j.wneu.2018.11.183DOI Listing
March 2019
14 Reads

Pelvic cellulitis caused by Raoultella planticola in a neutropenic patient.

J Infect Chemother 2019 Apr 25;25(4):298-301. Epub 2018 Oct 25.

Department I of Internal Medicine, Critical Care Medicine, University Hospital of Cologne, Cologne, Germany. Electronic address:

Raoultella planticola is a gram-negative, encapsulated, aerobic bacterium within the Enterobacteriaceae family. It has been primarily described as pathogen in cases with pneumonia and gastrointestinal infections. Here we describe a case of severe pelvic cellulitis in a patient with neutropenia following induction therapy for myeloid sarcoma. Read More

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http://dx.doi.org/10.1016/j.jiac.2018.09.013DOI Listing
April 2019
5 Reads

Primary Myeloid Sarcoma of the Breast: A Case Report and Review of Literature.

J Microsc Ultrastruct 2018 Oct-Dec;6(4):212-214

Department of Pathology, Faculty of Medicine, King Abdul Aziz University, Jeddah, Saudi Arabia.

Myeloid sarcoma (MS) of the breast is uncommon. We report this case of a 29-year-old female presented with a breast lump that was diagnosed as hamartoma by radiology. The lump was removed surgically. Read More

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http://dx.doi.org/10.4103/JMAU.JMAU_15_18DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6206754PMC
November 2018
14 Reads

Isolated Orbital Myeloid Sarcoma as a Therapy-related Myeloid Neoplasm.

Intern Med 2019 Apr 19;58(7):1045-1046. Epub 2018 Nov 19.

Department of Hematology, Tenshi Hospital, Japan.

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http://dx.doi.org/10.2169/internalmedicine.2105-18DOI Listing
April 2019
1 Read

Addition of melphalan to fludarabine/busulfan (FLU/BU4/MEL) provides survival benefit for patients with myeloid malignancy following allogeneic bone-marrow transplantation/peripheral blood stem-cell transplantation.

Int J Hematol 2019 Feb 17;109(2):197-205. Epub 2018 Nov 17.

Department of Hematology and Oncology, Osaka University Graduate School of Medicine, 2-2 Yamada-Oka, Suita, 565-0871, Japan.

A conditioning regimen with fludarabine and myeloablative dose of busulfan (FLU/BU4) has been commonly used in allogeneic hematopoietic cell transplantation (allo-HCT). However, there are two major problems with this regimen: insufficient anti-leukemic effect, especially in advanced cases, and slow time to complete donor-type chimerism, especially T-cell chimerism. To overcome these issues, we designed a combination regimen with FLU (150 mg/m), intravenous BU (12. Read More

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http://dx.doi.org/10.1007/s12185-018-2562-8DOI Listing
February 2019
17 Reads

LZTR1 is a regulator of RAS ubiquitination and signaling.

Science 2018 12 15;362(6419):1171-1177. Epub 2018 Nov 15.

CeMM Research Center for Molecular Medicine of the Austrian Academy of Sciences, 1090 Vienna, Austria.

In genetic screens aimed at understanding drug resistance mechanisms in chronic myeloid leukemia cells, inactivation of the cullin 3 adapter protein-encoding leucine zipper-like transcription regulator 1 () gene led to enhanced mitogen-activated protein kinase (MAPK) pathway activity and reduced sensitivity to tyrosine kinase inhibitors. Knockdown of the ortholog resulted in a Ras-dependent gain-of-function phenotype. Endogenous human LZTR1 associates with the main RAS isoforms. Read More

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http://www.sciencemag.org/lookup/doi/10.1126/science.aap8210
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http://dx.doi.org/10.1126/science.aap8210DOI Listing
December 2018
46 Reads

Histiocytic Sarcoma: Review, Discussion of Transformation From B-Cell Lymphoma, and Differential Diagnosis.

Arch Pathol Lab Med 2018 Nov;142(11):1322-1329

From the Department of Pathology, University of Michigan, Ann Arbor.

Context.—: Histiocytic sarcoma is a rare neoplasm of mature histiocytes with an aggressive clinical course that can arise de novo or from a low-grade B-cell lymphoma. In particular, chronic lymphocytic leukemia/small lymphocytic lymphoma is a very common malignancy in the Western hemisphere, and most cases of chronic lymphocytic leukemia/small lymphocytic lymphoma have an indolent course and behavior. Read More

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http://www.archivesofpathology.org/doi/10.5858/arpa.2018-022
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http://dx.doi.org/10.5858/arpa.2018-0220-RADOI Listing
November 2018
14 Reads

Acute myeloid leukaemia relapse presenting as cardiac myeloid sarcoma.

BMJ Case Rep 2018 Nov 1;2018. Epub 2018 Nov 1.

Radiation Oncology, Barbara Ann Karmanos Cancer Institute, Detroit, Michigan, USA.

A 50-year-old woman previously diagnosed with acute myeloid leukaemia presented with a 3-month history of shortness of breath and a right-sided facial rash. A chest CT revealed an intracardiac mass in the right atrium extending into her superior and inferior vena cava. Surgery was performed to remove the mass and pathology was consistent with myeloid sarcoma. Read More

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http://dx.doi.org/10.1136/bcr-2018-224419DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6214378PMC
November 2018
6 Reads

Sarcomas of the Oral and Maxillofacial Region: Analysis of 26 Cases with Emphasis on Diagnostic Challenges.

Pathol Oncol Res 2019 Apr 31;25(2):593-601. Epub 2018 Oct 31.

Department of Oral Medicine & Radiology, Maulana Azad Institute of Dental Sciences, New Delhi, India.

Sarcomas of the Oral and Maxillofacial Region (SOMR) are rare lesions which pose diagnostic and management challenges. We analyzed 26 cases of SOMR with respect to clinical presentation, histopathological subtype, treatment modalities, recurrence, and treatment outcome. In our series, Osteosarcoma (OS) was the most common type of sarcoma (7 cases), followed by 5 cases of Ewing's Sarcoma (ES), 3 cases each of Chondrosarcoma (CS) and Leiomyosarcoma (LMS), 2 cases each of Malignant Peripheral Nerve Sheath Tumor (MPNST), Pleomorphic Undifferentiated Sarcoma (PUS), Myeloid Sarcoma (MS)and Rhabdomyosarcoma (RMS). Read More

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http://link.springer.com/10.1007/s12253-018-0510-9
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http://dx.doi.org/10.1007/s12253-018-0510-9DOI Listing
April 2019
24 Reads

Myeloid Sarcoma of the Paranasal Sinuses in a Patient with Acute Myeloid Leukemia.

Tohoku J Exp Med 2018 10;246(2):141-146

Department of Otolaryngology-Head and Neck Surgery, Tohoku University School of Medicine.

Myeloid sarcoma (MS) is an uncommon extramedullary malignant tumor, and often represents a subgroup of acute myeloid leukemia (AML). MS of paranasal sinus origin is extremely rare. We report an uncommon case of sinonasal MS associated with AML, who was successfully treated with hematopoietic stem-cell transplantation. Read More

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https://www.jstage.jst.go.jp/article/tjem/246/2/246_141/_art
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http://dx.doi.org/10.1620/tjem.246.141DOI Listing
October 2018
20 Reads

A Case of Granulocytic Sarcoma or Extramedullary Acute Myelomonocytic Leukemia of the Gallbladder.

Am J Case Rep 2018 Oct 24;19:1262-1266. Epub 2018 Oct 24.

Department of Pulmonary Critical Care Medicine, Milford Regional Medical Center, Milford, MA, USA.

BACKGROUND Granulocytic sarcoma, or 'chloroma,' due to extramedullary acute myeloid leukemia (AML) or due to acute myelomonocytic leukemia (AML M5), is rare and is associated with a poor prognosis. This report is of a case of granulocytic sarcoma of the gallbladder and describes the approach to diagnosis and treatment. CASE REPORT A 74-year-old Hispanic woman from Ecuador presented to the emergency department with a five-day history of fever, jaundice, and right upper quadrant abdominal pain. Read More

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http://dx.doi.org/10.12659/AJCR.911390DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6213823PMC
October 2018
4 Reads

Cancer incidence in children and young adults living in industrially contaminated sites: from the Italian experience to the development of an international surveillance system.

Epidemiol Prev 2018 Sep-Dec;42(5-6S1):76-85

Section of Cancer Surveillance, International Agency for Research on Cancer, World Health Organization, Lyon (France).

Background: this paper is based upon work from COST Action ICSHNet. Children's environmental health is on the 2030 Agenda for Sustainable Development. The incidence of childhood cancer is increasing worldwide and in Europe. Read More

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http://dx.doi.org/10.19191/EP18.5-6.S1.P076.090DOI Listing
October 2018
5 Reads

[Clinicopathologic features of breast lymphoma in core needle biopsy].

Zhonghua Bing Li Xue Za Zhi 2018 Oct;47(10):737-742

Department of Pathology, Fudan University Shanghai Cancer Center; Department of Oncology, Shanghai Medical College, Fudan University, Shanghai 200032, China.

To investigate the clinicopathologic features and differential diagnosis of breast lymphoma in core needle biopsy. Seventy-two cases of breast lymphoma in core needle biopsy between 2011 and 2016 were extracted from the pathology database of Fudan University Shanghai Cancer Center. The clinicopathologic features were analyzed. Read More

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http://dx.doi.org/10.3760/cma.j.issn.0529-5807.2018.10.001DOI Listing
October 2018
23 Reads

Isolated myeloid sarcoma in the pancreas and orbit: A case report and review of literature.

World J Clin Cases 2018 Oct;6(11):477-482

Department of Haematology, Xijing Hospital, the Military Medical University of the PLA Air Force, Xi'an 710032, Shaanxi Province, China.

Myeloid sarcoma (MS) is a type of extramedullary solid haematological tumour. Myeloid sarcoma is classified into two types based on whether onset of the disease is complicated by haematologic diseases: extramedullary infiltration of leukaemia (leukaemic MS) and isolated myeloid sarcoma. The incidence of isolated myeloid sarcoma is low. Read More

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http://www.wjgnet.com/2307-8960/full/v6/i11/477.htm
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http://dx.doi.org/10.12998/wjcc.v6.i11.477DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6163140PMC
October 2018
4 Reads

Myeloid Sarcoma of Orbits: Effectiveness of a Low-Dose Radiation Regimen.

Case Rep Hematol 2018 9;2018:9071693. Epub 2018 Sep 9.

Division of Hematology and Oncology, Newark Beth Israel Medical Center, Newark, NJ, USA.

Acute myeloid leukemia (AML) can present with extramedullary involvement known as myeloid sarcoma (MS). We present the case of a young woman who was diagnosed with AML and MS in bilateral orbits, brain, omentum, and retroperitoneum. She was treated with induction chemotherapy. Read More

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https://www.hindawi.com/journals/crihem/2018/9071693/
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http://dx.doi.org/10.1155/2018/9071693DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6151198PMC
September 2018
7 Reads