2,837 results match your criteria Myeloid Sarcoma


Prevalence of deaths in a cohort of girls and women with cryopreserved ovarian tissue.

Acta Obstet Gynecol Scand 2019 Feb 15. Epub 2019 Feb 15.

The Fertility Clinic, section 4071, University Hospital of Copenhagen Rigshospitalet, Copenhagen, Denmark.

Introduction: Ovarian tissue cryopreservation (OTC) is increasingly offered to women in need of fertility preservation. However, little is known about the risk of these women dying before they use the preserved material.

Material And Methods: From 1999 to 2016, 927 girls and women underwent OTC in our center, prior to receiving gonadotoxic treatment. Read More

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http://dx.doi.org/10.1111/aogs.13576DOI Listing
February 2019

Evidence for an alternative fatty acid desaturation pathway increasing cancer plasticity.

Nature 2019 Feb 6. Epub 2019 Feb 6.

Laboratory of Cellular Metabolism and Metabolic Regulation, VIB-KU Leuven Center for Cancer Biology, VIB, Leuven, Belgium.

Most tumours have an aberrantly activated lipid metabolism that enables them to synthesize, elongate and desaturate fatty acids to support proliferation. However, only particular subsets of cancer cells are sensitive to approaches that target fatty acid metabolism and, in particular, fatty acid desaturation. This suggests that many cancer cells contain an unexplored plasticity in their fatty acid metabolism. Read More

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http://dx.doi.org/10.1038/s41586-019-0904-1DOI Listing
February 2019
2 Reads

Acute leukemias harboring KMT2A/MLLT10 fusion: a 10-year experience from a single genomics laboratory.

Genes Chromosomes Cancer 2019 Feb 1. Epub 2019 Feb 1.

Division of Laboratory Genetics and Genomics, Department of Laboratory Medicine and Pathology, Mayo Clinic, Rochester, MN, USA.

The MLLT10 (formerly AF10) gene is the fourth most common KMT2A fusion partner across all acute leukemias and requires at least three breaks to form an in-frame KMT2A/MLLT10 fusion due to the opposite orientation of each gene. A 10-year retrospective review was performed to identify individuals from all age groups that harbor KMT2A/MLLT10 fusion obtained by our KMT2A/MLLT10 dual-color dual-fusion fluorescence in situ hybridization (D-FISH) assay. Of the 60 unique individuals identified, 31 were male and 29 were female (M:F ratio, 1. Read More

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http://dx.doi.org/10.1002/gcc.22741DOI Listing
February 2019

A complex mutational profile and a distinct clonal evolution during NPM1 myeloid sarcoma.

Leuk Lymphoma 2019 Feb 1:1-3. Epub 2019 Feb 1.

b Laboratory of Hematology - Molecular Biology , University Hospital of Saint-Etienne , Saint-Etienne , France.

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http://dx.doi.org/10.1080/10428194.2019.1571199DOI Listing
February 2019

Second primary cancers in patients with acute lymphoblastic, chronic lymphocytic and hairy cell leukaemia.

Br J Haematol 2019 Jan 31. Epub 2019 Jan 31.

Division of Molecular Genetic Epidemiology, German Cancer Research Centre (DKFZ), Heidelberg, Germany.

Improvement of survival in lymphocytic leukaemia has been accompanied by the occurrence of second primary cancer (SPCs). Based on Swedish Family Cancer Database, we applied bi-directional analyses in which relative risks (RRs) were calculated for any SPCs in patients with chronic lymphocytic leukaemia (CLL), acute lymphoblastic leukaemia (ALL) and hairy cell leukaemia (HCL) and the risks of these leukaemias as SPCs. After CLL, RRs were significant for 20 SPCs, and high for skin squamous cell cancer (24·58 for in situ and 7·63 for invasive), Merkel cell carcinoma (14·36), Hodgkin lymphoma (7·16) and Kaposi sarcoma (6·76). Read More

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http://dx.doi.org/10.1111/bjh.15777DOI Listing
January 2019
1 Read

Myeloid Sarcoma with Megakaryoblastic Differentiation Arising in the Conjunctiva.

Ocul Oncol Pathol 2019 Jan 22;5(1):28-35. Epub 2018 May 22.

Eyelid Experts, Palm Beach Gardens, Florida, USA.

An 87-year-old woman not known to have either a lymphoma or leukemia developed a left multinodular, fish-flesh superior epibulbar and forniceal mass. A biopsy disclosed a blastic tumor with scattered multinucleated immature megakaryoblasts. Immunophenotyping of bone marrow cells revealed strong positivity for CD7, CD31, CD43, CD45, CD61, and CD117; CD71, myeloperoxidase, and lysozyme were also positive in scattered cells. Read More

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https://www.karger.com/Article/FullText/488057
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http://dx.doi.org/10.1159/000488057DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6341420PMC
January 2019
4 Reads

Using the Spleen as an Systemic Immune Barometer Alongside Osteosarcoma Disease Progression and Immunotherapy with -PD-L1.

Sarcoma 2018 12;2018:8694397. Epub 2018 Dec 12.

Department of Orthopaedics, West Virginia University, Morgantown, WV, USA.

Indications for immunotherapies are still unclear, and there is a great need for real-time patient immune status monitoring. In this study, we confirmed that the local and systemic immune profiles of an orthotopic osteosarcoma model with or without luciferase transfection were statistically equivalent. Next, we used flow cytometry to describe systemic immune cell populations influenced by osteosarcoma disease progression. Read More

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https://www.hindawi.com/journals/sarcoma/2018/8694397/
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http://dx.doi.org/10.1155/2018/8694397DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6311869PMC
December 2018
5 Reads

Remarks on Myeloid Sarcoma in Children

Authors:

Turk J Haematol 2019 Jan 17. Epub 2019 Jan 17.

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http://dx.doi.org/10.4274/tjh.2019.0002DOI Listing
January 2019
1 Read

Heart failure due to cardiac myeloid sarcoma.

Eur Heart J Cardiovasc Imaging 2019 Jan 10. Epub 2019 Jan 10.

University Clinic of Internal Medicine III, Cardiology and Angiology, Medical University of Innsbruck, Anichstrasse 35, Innsbruck, Austria.

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http://dx.doi.org/10.1093/ehjci/jey226DOI Listing
January 2019
4 Reads

Myeloid sarcoma presenting as an unusual limbal mass.

BMJ Case Rep 2019 Jan 14;12(1). Epub 2019 Jan 14.

Department of Medical Oncology, Institute Rotary Cancer Hospital, All India Institute of Medical Sciences, New Delhi, New Delhi, India.

A 19-year-old woman presented to the outpatient department with occasional ocular pain and redness and a perilimbal mass, which she noticed 5 months ago in her left eye. She had no systemic complaints. Ultrasound biomicroscopy of the mass showed a hypoechoic lesion with uniform reflectivity. Read More

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http://casereports.bmj.com/lookup/doi/10.1136/bcr-2018-22628
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http://dx.doi.org/10.1136/bcr-2018-226284DOI Listing
January 2019
4 Reads

Effect of Neutropenic Diet on Infection Rates in Cancer Patients With Neutropenia: A Meta-analysis of Randomized Controlled Trials.

Am J Clin Oncol 2019 Jan 8. Epub 2019 Jan 8.

Sidney Kimmel Comprehensive Cancer Center, Johns Hopkins University, Baltimore MD.

Introduction: Neutropenic diets are commonly prescribed to cancer patients with neutropenia with the intention of reducing rates of infection. These diets are restrictive and are associated with lower patient satisfaction and possibly malnutrition. Further, it is unclear if these restrictive diets are effective in reducing infection. Read More

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http://dx.doi.org/10.1097/COC.0000000000000514DOI Listing
January 2019
14 Reads

Co-Occurrence of Myeloid Sarcoma of the Lymph Node and Acute Monocytic Myeloid Leukemia: A Case Report and Literature Review.

Case Rep Oncol 2018 Sep-Dec;11(3):791-799. Epub 2018 Nov 29.

Division of Hematology and Oncology, Bronx Care Health System, Affiliated with Icahn School of Medicine at Mount Sinai, Bronx, New York, USA.

Background: Acute myeloid leukemia (AML) is the most common leukemia in adults. According to the French-American-British (FAB) system, monocytic leukemia is classified as M5. Myeloid sarcoma further occurs in 3-5% of AML. Read More

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http://dx.doi.org/10.1159/000494830DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6323399PMC
November 2018
2 Reads

Primary Vaginal Chloroma: A Rare Case Report.

Int J Hematol Oncol Stem Cell Res 2018 Jul;12(3):166-168

Department of Medical and Paediatric Oncology, Gujarat Cancer and Research Institute, Ahmedabad, Gujarat, India.

Chloroma (granulocytic sarcoma or myeloid sarcoma) is a rare malignant extra-medullary neoplasm of myeloid precursor cells. It is usually associated with myeloproliferative disorders but very rarely may precede the onset of leukaemia. Here we are presenting a rare case of chloroma in a female patient without initial presentation of AML. Read More

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http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6305264PMC
July 2018
1 Read

A case of primary cutaneous Ewing sarcoma in a neutropenic patient.

J Cutan Pathol 2019 Mar 16;46(3):238-241. Epub 2019 Jan 16.

Department of Dermatology, University of Iowa Hospitals and Clinics, Iowa City, Iowa.

Primary cutaneous Ewing sarcoma is a rare clinical presentation of Ewing sarcoma, usually occurring as a small, localized tumor on the extremities of young adults and associated with favorable prognosis. We report a case of primary cutaneous Ewing sarcoma, which presented on the sole of the foot of a 27-year-old patient with relapsed acute myeloid leukemia and neutropenia. Diagnosis was determined through histological features and staining, as well as fluorescence in situ hybridization and molecular testing. Read More

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http://dx.doi.org/10.1111/cup.13406DOI Listing
March 2019
3 Reads

Male with myelofibrosis and ulceronecrotic lesions.

Rev Assoc Med Bras (1992) 2018 Dec;64(12):1073-1074

Department of Internal Medicine, São Francisco Hospital, Ribeirão Preto, SP, Brasil.

Objective: Granulocytic sarcoma also called myeloid sarcoma is an extramedullary tumour of immature granulocytic cells. It is a rare entity, and mostly accompanied by acute myeloid leukaemia. It is observed during the course of myeloproliferative disorders especially in chronic myeloid leukaemia and myelodysplastic syndromes. Read More

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http://dx.doi.org/10.1590/1806-9282.64.12.1073DOI Listing
December 2018
2 Reads

A Lateral Neck Myeloid Sarcoma Presenting as Acute Otitis Externa.

Arch Iran Med 2018 Nov 1;21(11):544-546. Epub 2018 Nov 1.

Iranian Research Center for HIV/AIDS (IRCHA), Tehran University of Medical Sciences, Tehran, Iran.

Myeloid sarcoma (MS) is a solid extra-medullary tumor of immature myeloid cells which could occur before, during or after remission of acute leukemia at any site on the body. Owing to variation in differential diagnosis, pathologic evaluation and immunohistochemical staining are essential for definitive diagnosis. Rarely, MS has been shown as an isolated extramedullary relapse (iEMR) after allogeneic stem cell transplantation (allo-SCT), which often does not necessarily result in bone marrow involvement. Read More

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November 2018
2 Reads

[Myeloid Sarcoma of the Testis].

Hinyokika Kiyo 2018 Nov;64(11):459-463

The Department of Urology, Yokohama City Minato Red Cross Hospital.

A 68-year-old man with swelling of his left testis was referred to our hospital. There was no history of hematologic disease. The diameter of the testicular mass was 40 mm. Read More

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http://dx.doi.org/10.14989/ActaUrolJap_64_11_459DOI Listing
November 2018
1 Read

Successful Treatment of Relapsed Pediatric Acute Myeloid Leukemia Presenting as Central Nervous System Myeloid Sarcoma: A Single-Institution Case Series.

J Pediatr Hematol Oncol 2018 Dec 12. Epub 2018 Dec 12.

Department of Pediatric Hematology-Oncology, University of Louisville, Louisville, KY.

Relapsed acute myeloid leukemia presenting as an isolated central nervous system myeloid sarcoma (CNS MS) is very rare and generally entails poor outcomes. CNS MS treatment is not well defined and can include systemic chemotherapy, intrathecal chemotherapy, radiation therapy, or hematopoietic stem cell transplant. Thiotepa, vinorelbine, topotecan, and clofarabine (TVTC) has been successful for reinduction therapy in relapsed/refractory leukemia to induce remission before hematopoietic stem cell transplant. Read More

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http://dx.doi.org/10.1097/MPH.0000000000001383DOI Listing
December 2018
4 Reads

Myelolytic Treatments Enhance Oncolytic Herpes Virotherapy in Models of Ewing Sarcoma by Modulating the Immune Microenvironment.

Mol Ther Oncolytics 2018 Dec 18;11:62-74. Epub 2018 Oct 18.

Center for Childhood Cancer and Blood Diseases, Nationwide Children's Hospital, The Ohio State University, Columbus, OH 43205, USA.

Ewing sarcoma is a highly aggressive cancer that promotes the infiltration and activation of pro-tumor M2-like macrophages. Oncolytic virotherapy that selectively infects and destroys cancer cells is a promising option for treating Ewing sarcoma. The effect of tumor macrophages on oncolytic virus therapy, however, is variable among solid tumors and is unknown in Ewing sarcoma. Read More

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http://dx.doi.org/10.1016/j.omto.2018.10.001DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6249791PMC
December 2018
3 Reads

A case of myeloid sarcoma presenting with an orbital mass, hearing loss, and multiple cranial neuropathies.

Turk J Pediatr 2018 ;60(3):322-325

Department of Pediatrics, Gachon University, Gil Medical Center, Incheon, South Korea.

Lim SH, Nam HN, Lim KI, Jeon IS. A case of myeloid sarcoma presenting with an orbital mass, hearing loss, and multiple cranial neuropathies. Turk J Pediatr 2018; 60: 322-325. Read More

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http://dx.doi.org/10.24953/turkjped.2018.03.015DOI Listing
January 2018
3 Reads

Increased angiogenesis seems to correlate with inferior overall survival in myeloid sarcoma patients.

Pol J Pathol 2018 ;69(3):254-265

Myeloid sarcomas (MS) are tumors composed by myeloid elements and developing outside bone marrow. The prognosis is overall poor, only stem cell transplantation being consistently reposted as a potentially curative approach. In this study we explored whether microvessel density, a biomarker of angiogenesis, might be relevant in MS. Read More

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http://dx.doi.org/10.5114/pjp.2018.79545DOI Listing
January 2018
1 Read

Pelvic cellulitis caused by Raoultella planticola in a neutropenic patient.

J Infect Chemother 2018 Oct 25. Epub 2018 Oct 25.

Department I of Internal Medicine, Critical Care Medicine, University Hospital of Cologne, Cologne, Germany. Electronic address:

Raoultella planticola is a gram-negative, encapsulated, aerobic bacterium within the Enterobacteriaceae family. It has been primarily described as pathogen in cases with pneumonia and gastrointestinal infections. Here we describe a case of severe pelvic cellulitis in a patient with neutropenia following induction therapy for myeloid sarcoma. Read More

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http://dx.doi.org/10.1016/j.jiac.2018.09.013DOI Listing
October 2018
4 Reads

Primary Myeloid Sarcoma of the Breast: A Case Report and Review of Literature.

J Microsc Ultrastruct 2018 Oct-Dec;6(4):212-214

Department of Pathology, Faculty of Medicine, King Abdul Aziz University, Jeddah, Saudi Arabia.

Myeloid sarcoma (MS) of the breast is uncommon. We report this case of a 29-year-old female presented with a breast lump that was diagnosed as hamartoma by radiology. The lump was removed surgically. Read More

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http://dx.doi.org/10.4103/JMAU.JMAU_15_18DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6206754PMC
November 2018
9 Reads

Isolated Orbital Myeloid Sarcoma as a Therapy-related Myeloid Neoplasm.

Intern Med 2018 Nov 19. Epub 2018 Nov 19.

Department of Hematology, Tenshi Hospital, Japan.

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http://dx.doi.org/10.2169/internalmedicine.2105-18DOI Listing
November 2018
1 Read

LZTR1 is a regulator of RAS ubiquitination and signaling.

Science 2018 12 15;362(6419):1171-1177. Epub 2018 Nov 15.

CeMM Research Center for Molecular Medicine of the Austrian Academy of Sciences, 1090 Vienna, Austria.

In genetic screens aimed at understanding drug resistance mechanisms in chronic myeloid leukemia cells, inactivation of the cullin 3 adapter protein-encoding leucine zipper-like transcription regulator 1 () gene led to enhanced mitogen-activated protein kinase (MAPK) pathway activity and reduced sensitivity to tyrosine kinase inhibitors. Knockdown of the ortholog resulted in a Ras-dependent gain-of-function phenotype. Endogenous human LZTR1 associates with the main RAS isoforms. Read More

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http://www.sciencemag.org/lookup/doi/10.1126/science.aap8210
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http://dx.doi.org/10.1126/science.aap8210DOI Listing
December 2018
32 Reads

Histiocytic Sarcoma: Review, Discussion of Transformation From B-Cell Lymphoma, and Differential Diagnosis.

Arch Pathol Lab Med 2018 Nov;142(11):1322-1329

From the Department of Pathology, University of Michigan, Ann Arbor.

Context.—: Histiocytic sarcoma is a rare neoplasm of mature histiocytes with an aggressive clinical course that can arise de novo or from a low-grade B-cell lymphoma. In particular, chronic lymphocytic leukemia/small lymphocytic lymphoma is a very common malignancy in the Western hemisphere, and most cases of chronic lymphocytic leukemia/small lymphocytic lymphoma have an indolent course and behavior. Read More

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http://www.archivesofpathology.org/doi/10.5858/arpa.2018-022
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http://dx.doi.org/10.5858/arpa.2018-0220-RADOI Listing
November 2018
9 Reads

Acute myeloid leukaemia relapse presenting as cardiac myeloid sarcoma.

BMJ Case Rep 2018 Nov 1;2018. Epub 2018 Nov 1.

Radiation Oncology, Barbara Ann Karmanos Cancer Institute, Detroit, Michigan, USA.

A 50-year-old woman previously diagnosed with acute myeloid leukaemia presented with a 3-month history of shortness of breath and a right-sided facial rash. A chest CT revealed an intracardiac mass in the right atrium extending into her superior and inferior vena cava. Surgery was performed to remove the mass and pathology was consistent with myeloid sarcoma. Read More

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http://dx.doi.org/10.1136/bcr-2018-224419DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6214378PMC
November 2018
5 Reads

Sarcomas of the Oral and Maxillofacial Region: Analysis of 26 Cases with Emphasis on Diagnostic Challenges.

Pathol Oncol Res 2018 Oct 31. Epub 2018 Oct 31.

Department of Oral Medicine & Radiology, Maulana Azad Institute of Dental Sciences, New Delhi, India.

Sarcomas of the Oral and Maxillofacial Region (SOMR) are rare lesions which pose diagnostic and management challenges. We analyzed 26 cases of SOMR with respect to clinical presentation, histopathological subtype, treatment modalities, recurrence, and treatment outcome. In our series, Osteosarcoma (OS) was the most common type of sarcoma (7 cases), followed by 5 cases of Ewing's Sarcoma (ES), 3 cases each of Chondrosarcoma (CS) and Leiomyosarcoma (LMS), 2 cases each of Malignant Peripheral Nerve Sheath Tumor (MPNST), Pleomorphic Undifferentiated Sarcoma (PUS), Myeloid Sarcoma (MS)and Rhabdomyosarcoma (RMS). Read More

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http://link.springer.com/10.1007/s12253-018-0510-9
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http://dx.doi.org/10.1007/s12253-018-0510-9DOI Listing
October 2018
11 Reads

Myeloid Sarcoma of the Paranasal Sinuses in a Patient with Acute Myeloid Leukemia.

Tohoku J Exp Med 2018 10;246(2):141-146

Department of Otolaryngology-Head and Neck Surgery, Tohoku University School of Medicine.

Myeloid sarcoma (MS) is an uncommon extramedullary malignant tumor, and often represents a subgroup of acute myeloid leukemia (AML). MS of paranasal sinus origin is extremely rare. We report an uncommon case of sinonasal MS associated with AML, who was successfully treated with hematopoietic stem-cell transplantation. Read More

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https://www.jstage.jst.go.jp/article/tjem/246/2/246_141/_art
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http://dx.doi.org/10.1620/tjem.246.141DOI Listing
October 2018
12 Reads

A Case of Granulocytic Sarcoma or Extramedullary Acute Myelomonocytic Leukemia of the Gallbladder.

Am J Case Rep 2018 Oct 24;19:1262-1266. Epub 2018 Oct 24.

Department of Pulmonary Critical Care Medicine, Milford Regional Medical Center, Milford, MA, USA.

BACKGROUND Granulocytic sarcoma, or 'chloroma,' due to extramedullary acute myeloid leukemia (AML) or due to acute myelomonocytic leukemia (AML M5), is rare and is associated with a poor prognosis. This report is of a case of granulocytic sarcoma of the gallbladder and describes the approach to diagnosis and treatment. CASE REPORT A 74-year-old Hispanic woman from Ecuador presented to the emergency department with a five-day history of fever, jaundice, and right upper quadrant abdominal pain. Read More

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http://dx.doi.org/10.12659/AJCR.911390DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6213823PMC
October 2018
3 Reads

Cancer incidence in children and young adults living in industrially contaminated sites: from the Italian experience to the development of an international surveillance system.

Epidemiol Prev 2018 Sep-Dec;42(5-6S1):76-85

Section of Cancer Surveillance, International Agency for Research on Cancer, World Health Organization, Lyon (France).

Background: this paper is based upon work from COST Action ICSHNet. Children's environmental health is on the 2030 Agenda for Sustainable Development. The incidence of childhood cancer is increasing worldwide and in Europe. Read More

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http://dx.doi.org/10.19191/EP18.5-6.S1.P076.090DOI Listing
October 2018
2 Reads

[Clinicopathologic features of breast lymphoma in core needle biopsy].

Zhonghua Bing Li Xue Za Zhi 2018 Oct;47(10):737-742

Department of Pathology, Fudan University Shanghai Cancer Center; Department of Oncology, Shanghai Medical College, Fudan University, Shanghai 200032, China.

To investigate the clinicopathologic features and differential diagnosis of breast lymphoma in core needle biopsy. Seventy-two cases of breast lymphoma in core needle biopsy between 2011 and 2016 were extracted from the pathology database of Fudan University Shanghai Cancer Center. The clinicopathologic features were analyzed. Read More

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http://dx.doi.org/10.3760/cma.j.issn.0529-5807.2018.10.001DOI Listing
October 2018
16 Reads

Isolated myeloid sarcoma in the pancreas and orbit: A case report and review of literature.

World J Clin Cases 2018 Oct;6(11):477-482

Department of Haematology, Xijing Hospital, the Military Medical University of the PLA Air Force, Xi'an 710032, Shaanxi Province, China.

Myeloid sarcoma (MS) is a type of extramedullary solid haematological tumour. Myeloid sarcoma is classified into two types based on whether onset of the disease is complicated by haematologic diseases: extramedullary infiltration of leukaemia (leukaemic MS) and isolated myeloid sarcoma. The incidence of isolated myeloid sarcoma is low. Read More

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http://www.wjgnet.com/2307-8960/full/v6/i11/477.htm
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http://dx.doi.org/10.12998/wjcc.v6.i11.477DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6163140PMC
October 2018
3 Reads

Myeloid Sarcoma of Orbits: Effectiveness of a Low-Dose Radiation Regimen.

Case Rep Hematol 2018 9;2018:9071693. Epub 2018 Sep 9.

Division of Hematology and Oncology, Newark Beth Israel Medical Center, Newark, NJ, USA.

Acute myeloid leukemia (AML) can present with extramedullary involvement known as myeloid sarcoma (MS). We present the case of a young woman who was diagnosed with AML and MS in bilateral orbits, brain, omentum, and retroperitoneum. She was treated with induction chemotherapy. Read More

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https://www.hindawi.com/journals/crihem/2018/9071693/
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http://dx.doi.org/10.1155/2018/9071693DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6151198PMC
September 2018
5 Reads

Tumor-derived microRNAs induce myeloid suppressor cells and predict immunotherapy resistance in melanoma.

J Clin Invest 2018 Dec 5;128(12):5505-5516. Epub 2018 Nov 5.

Unit of Immunotherapy of Human Tumors, Fondazione Istituto di Ricovero e Cura a Carattere Scientifico (IRCCS) Istituto Nazionale dei Tumori di Milano, Milan, Italy.

The accrual of myeloid-derived suppressor cells (MDSCs) represents a major obstacle to effective immunotherapy in cancer patients, but the mechanisms underlying this process in the human setting remain elusive. Here, we describe a set of microRNAs (miR-146a, miR-155, miR-125b, miR-100, let-7e, miR-125a, miR-146b, miR-99b) that are associated with MDSCs and resistance to treatment with immune checkpoint inhibitors in melanoma patients. The miRs were identified by transcriptional analyses as being responsible for the conversion of monocytes into MDSCs (CD14+HLA-DRneg cells) mediated by melanoma extracellular vesicles (EVs) and were shown to recreate MDSC features upon transfection. Read More

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http://dx.doi.org/10.1172/JCI98060DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6264733PMC
December 2018
13 Reads

Obstructive jaundice caused by myeloid sarcoma in duodenal ampulla.

Dig Liver Dis 2019 Feb 5;51(2):321. Epub 2018 Sep 5.

First Affiliated Hospital of Nanchang University, General Surgery Center, China.

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https://linkinghub.elsevier.com/retrieve/pii/S15908658183088
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http://dx.doi.org/10.1016/j.dld.2018.08.004DOI Listing
February 2019
3 Reads

Predicting and Preventing Anthracycline-Related Cardiotoxicity.

Am Soc Clin Oncol Educ Book 2018 May(38):3-12

From the City of Hope, Duarte, CA; University of Alabama at Birmingham, Birmingham, AL.

Anthracyclines (doxorubicin, daunorubicin, epirubicin, and idarubicin) are among the most potent chemotherapeutic agents and have truly revolutionized the management of childhood cancer. They form the backbone of chemotherapy regimens used to treat childhood acute lymphoblastic leukemia, acute myeloid leukemia, Hodgkin lymphoma, Ewing sarcoma, osteosarcoma, and neuroblastoma. More than 50% of children with cancer are treated with anthracyclines. Read More

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http://dx.doi.org/10.1200/EDBK_100015DOI Listing
May 2018
4 Reads

Mediastinal Myeloid Sarcoma with TP53 Mutation Preceding Acute Myeloid Leukemia with a PICALM-MLLT10 Fusion Gene.

Acta Haematol 2018 18;140(2):97-104. Epub 2018 Sep 18.

Department of Hematology, AZ Sint-Jan Brugge-Oostende, Bruges, Belgium.

Introduction: Myeloid sarcoma (MS), previously known as granulocytic sarcoma or chloroma, is a rare neoplastic condition defined as a tumor mass consisting of myeloblasts or immature myeloid cells occurring at an extramedullary site. Clinical presentation is diverse and determined by a tumor mass effect or local organ dysfunction.

Case Report: We report the case of a 25-year-old previously healthy male with rapidly progressive shortness of breath. Read More

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http://dx.doi.org/10.1159/000491596DOI Listing
September 2018
3 Reads

Use of Radiation in Extramedullary Leukemia/Chloroma: Guidelines From the International Lymphoma Radiation Oncology Group.

Int J Radiat Oncol Biol Phys 2018 10 29;102(2):314-319. Epub 2018 May 29.

Department of Radiation Oncology, Memorial Sloan Kettering Cancer Center, New York, New York. Electronic address:

Survival times for patients with leukemia generally have improved in recent decades, and this improvement has been attributed to an enhanced understanding of the genetics driving the cause of the disease and improved combinations of chemotherapy and targeted therapy. Durable control of systemic disease in blood and bone marrow has significantly improved survival, but extramedullary relapse can pose therapeutic challenges for which radiation therapy can have an important role. This report discusses the current role of radiation therapy for patients with leukemia, specifically the extramedullary manifestations of leukemia. Read More

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http://dx.doi.org/10.1016/j.ijrobp.2018.05.045DOI Listing
October 2018
2 Reads

Intraoral granulocytic sarcoma as a manifestation of myelofibrosis: A case report and review of the literature.

Spec Care Dentist 2018 Nov 6;38(6):409-420. Epub 2018 Sep 6.

Department of Oral Surgery and Pathology, Faculty of Dentistry, Universidade Federal de Minas Gerais, Minas Gerais, Brazil.

Granulocytic sarcoma (GS) is an extramedullary tumor associated with myelodysplastic syndromes or myeloproliferative diseases. Intraoral manifestations are considered uncommon, with a reasonable number of cases, and are mostly related to leukemia. The association of oral GS and myelofibrosis is very rare and only three cases have been published. Read More

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http://dx.doi.org/10.1111/scd.12325DOI Listing
November 2018
2 Reads

Assessing the feasibility and validity of the Toronto Childhood Cancer Stage Guidelines: a population-based registry study.

Lancet Child Adolesc Health 2018 03 1;2(3):173-179. Epub 2018 Feb 1.

Dana-Farber/Boston Children's Cancer and Blood Disorders Center, Boston, MD, USA.

Background: Cancer stage at diagnosis is crucial for assessing global efforts to increase awareness of childhood cancer and improve outcomes. However, consistent information on childhood cancer stage is absent from population cancer registries worldwide. The Toronto Childhood Cancer Stage Guidelines, compiled through an international consensus process, were designed to provide a standard framework for collection of information on stage at diagnosis of childhood cancers. Read More

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http://dx.doi.org/10.1016/S2352-4642(18)30023-3DOI Listing
March 2018
20 Reads

Histiocytic cell neoplasms involving the bone marrow: summary of the workshop cases submitted to the 18th Meeting of the European Association for Haematopathology (EAHP) organized by the European Bone Marrow Working Group, Basel 2016.

Ann Hematol 2018 Nov 6;97(11):2117-2128. Epub 2018 Aug 6.

Department of Pathology 824, Radboud University Medical Center, POB 9101, 6500 HB, Nijmegen, The Netherlands.

The bone marrow is a preferential site for both reactive and neoplastic histiocytic proliferations. The differential diagnosis ranges from reactive histiocyte hyperplasia in systemic infections, vaccinations, storage diseases, post myeloablative therapy, due to increased cell turnover, and in hemophagocytic lymphohistiocytosis, through extranodal Rosai-Dorfman disease to neoplasms derived from histiocytes, including histiocytic sarcomas (HS), Langerhans cell histiocytoses (LCH), Erdheim-Chester disease (ECD), and disseminated juvenile xanthogranuloma (JXG). One of the most important recent developments in understanding the biology of histiocytic neoplasms and in contributing to diagnosis was the detection of recurrent mutations of genes of the Ras/Raf/MEK/ERK signaling pathway, in particular the BRAF mutation, in LCH and ECD. Read More

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http://dx.doi.org/10.1007/s00277-018-3436-0DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6182749PMC
November 2018
18 Reads

Clinicopathologic Features and Clinical Outcome Differences in De Novo Versus Secondary Histiocytic Sarcomas: A Multi-institutional Experience and Review of the Literature.

Clin Lymphoma Myeloma Leuk 2018 Oct 1;18(10):e427-e435. Epub 2018 Aug 1.

Department of Pathology, University of Alabama at Birmingham, Birmingham, AL. Electronic address:

Introduction: Histiocytic sarcoma (HS) is a rare malignant neoplasm that can occur in patients with a history of treatment for hematologic or solid tumors. Because no optimal treatment has been defined and standardized, the treatment modalities used and outcomes reported have been highly variable. In the present study, 3 major institutions explored the clinicopathologic features of de novo and secondary HS. Read More

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http://dx.doi.org/10.1016/j.clml.2018.07.286DOI Listing
October 2018
6 Reads

NPM-hMLF1 fusion protein suppresses defects of a Drosophila FTLD model expressing the human FUS gene.

Sci Rep 2018 Jul 26;8(1):11291. Epub 2018 Jul 26.

Department of Applied Biology, Kyoto Institute of Technology, Matsugasaki, Sakyo-ku, Kyoto, 606-8585, Japan.

Fused in sarcoma (FUS) was identified as a component of typical inclusions in frontotemporal lobar degeneration (FTLD) and amyotrophic lateral sclerosis (ALS). In FTLD, both nuclear and cytoplasmic inclusions with wild-type FUS exist, while cytoplasmic inclusions with a mutant-form of FUS occur in many ALS cases. These observations imply that FUS plays a role across these two diseases. Read More

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http://dx.doi.org/10.1038/s41598-018-29716-9DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6062494PMC
July 2018
16 Reads

Myeloid sarcoma without circulating leukemia mimicking gastrointestinal malignancy and lymphoma.

Hematol Rep 2018 May 14;10(2):7040. Epub 2018 Jun 14.

Division of Hematology and Oncology, St. Louis University School of Medicine, MO, USA.

We present an unusual case of myeloid sarcoma with ascites and abdominal pain in which initial clinical, laboratory, and imaging studies suggested a gastrointestinal malignancy or lymphoma. Subsequent detection of leukemic ascites and blasts in a gastric, small bowel, and skin biopsy supported a diagnosis of myeloid sarcoma. Bone marrow biopsy revealed 15% blasts, and cytogenetics with an inversion 16 rearrangement was diagnostic of acute myeloid leukemia (AML). Read More

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http://dx.doi.org/10.4081/hr.2018.7040DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6036982PMC
May 2018
9 Reads

De Novo Myeloid Sarcoma as a Cause of Small Bowel Obstruction: A Case Report.

J Belg Soc Radiol 2017 Aug 14;101(1):28. Epub 2017 Aug 14.

Heilig Hartziekenhuis, BE.

Myeloid sarcoma (MS) is an extremely rare disease, closely correlated to Acute Myeloid Leukamia (AML) and presenting as a tumoral lesion in potentially any anatomic location. It is seen either concomitant with AML, during remission, or more seldom, prior to any detectable haematological abnormality. While MS remains a difficult diagnosis, this rare tumor must be included in the differential diagnosis of atypical, local obstructive abdominal processes, especially when coinciding with a myeloproliferative disorder. Read More

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http://dx.doi.org/10.5334/jbr-btr.1353DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6032658PMC
August 2017
17 Reads

A Middle-Aged Man With Jaundice and a Gastric Tumor.

Gastroenterology 2018 12 19;155(6):1699-1700. Epub 2018 Jul 19.

Department of Gastroenterology and Hepatology, Leiden University Medical Center, Leiden, the Netherlands.

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http://dx.doi.org/10.1053/j.gastro.2018.06.088DOI Listing
December 2018
2 Reads

An uncommon granulocytic sarcoma of the breast: a case report and literature review.

Onco Targets Ther 2018 25;11:3685-3690. Epub 2018 Jun 25.

Department of Breast Surgical Oncology, National Cancer Center/Cancer Hospital, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing, People's Republic of China,

Granulocytic sarcoma (GS) is an uncommon extramedullary manifestation of acute myeloid leukemia. GS is often likely to be clinically misdiagnosed as another type of primary breast cancer due to its rarity. We report an uncommon case of breast GS in a patient and review the relevant literature. Read More

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https://www.dovepress.com/an-uncommon-granulocytic-sarcoma-o
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http://dx.doi.org/10.2147/OTT.S149149DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6026916PMC
June 2018
9 Reads

Clinical characteristics of pediatric patients with myeloid sarcoma without bone marrow involvement in Japan.

Int J Hematol 2018 Oct 3;108(4):438-442. Epub 2018 Jul 3.

Leukemia/Lymphoma Committee of Japanese Society of Pediatric Hematology and Oncology, Tokyo, Japan.

Myeloid sarcoma (MS) is a rare neoplastic condition that is often described in association with acute myeloid leukemia (AML). MS in childhood has received little attention, particularly in Japan. We carried out a nationwide retrospective analysis of Japanese children diagnosed with MS without bone marrow involvement. Read More

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http://dx.doi.org/10.1007/s12185-018-2492-5DOI Listing
October 2018
8 Reads

Peritoneal Myeloid Sarcoma in a Patient Treated for a Testicular Seminoma.

Am J Case Rep 2018 Jun 29;19:763-766. Epub 2018 Jun 29.

Division of Medical Oncology, Mercy Hospital, Metz-Thionville Regional Hospital Center, Ars-Laquenexy, France.

BACKGROUND Myeloid sarcoma is a rare extramedullary soft tissue neoplasm composed of myeloblastic cells, usually associated to hematologic tumor disorders and a poor prognosis. Its diagnosis is very difficult as radiological images are not specific. Histology and immunohistochemistry are necessary for an accurate diagnosis. Read More

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https://www.amjcaserep.com/abstract/index/idArt/910434
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http://dx.doi.org/10.12659/AJCR.910434DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6055577PMC
June 2018
7 Reads