3,029 results match your criteria Myeloid Sarcoma


Myeloid sarcoma of the nasal cavity in a 15-month-old child: A case report.

Medicine (Baltimore) 2020 Jul;99(27):e21119

Department of Otolaryngology-Head and Neck Surgery.

Introduction: Myeloid sarcoma (MS) is a rare tumor mass. It may occur at any extramedullary anatomic sites but is uncommon in the sinonasal location.MS commonly presents concurrently with acute myeloid leukemia (AML), but it may predate AML over several months or years, named isolated MS. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1097/MD.0000000000021119DOI Listing

Isolated Intracranial Myeloid Sarcoma Mimicking Malignant Lymphoma: A Diagnostic Challenge and Literature Reviews.

Onco Targets Ther 2020 25;13:6085-6092. Epub 2020 Jun 25.

Department of Pathology and Key Laboratories for Xinjiang Endemic and Ethnic Diseases, The First Affiliated Hospital, Shihezi University of Medical, Shihezi, 832002, People's Republic of China.

Isolated intracranial myeloid sarcoma (MS) is an unusual variant tumor with few cases reported so far in the medical literature. A 29-year-old woman was admitted to our hospital presenting progressive visual loss in the right eye and weight loss (20 kg) without a previous history of hematological disease (HD). Radiologic evaluation showed the evidence of intracranial mass. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.2147/OTT.S245828DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7323804PMC
June 2020
1.342 Impact Factor

Extra-medullary recurrence of myeloid leukemia as myeloid sarcoma after allogeneic stem cell transplantation: impact of conditioning intensity.

Bone Marrow Transplant 2020 Jun 30. Epub 2020 Jun 30.

Klinik für Innere Medizin II, Hämatologie und Internistische Onkologie, Universitätsklinikum Jena, Jena, Germany.

Myeloid sarcoma (MS) as a solid extra-medullary (EM) manifestation of acute myeloid leukemia (AML), myeloproliferative or myelodysplastic syndromes is a rare presentation of relapse after allogeneic hematopoietic stem cell transplantation (HSCT). The databases of the Departments of Hematology and Oncology of the University Hospitals of Jena and Rostock were screened for patients aged 18 years or older for onset of MS after HSCT for myeloid malignancies between 2002 and 2019. Nineteen patients with MS were identified, the majority of whom had received reduced-intensity conditioning (RIC). Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1038/s41409-020-0984-4DOI Listing

Tracheobronchial Myeloid Sarcoma (Chloroma).

J Bronchology Interv Pulmonol 2020 Jun 24. Epub 2020 Jun 24.

Pathology Laboratory, Histo Bio Diagnosis S.A., Athens, Greece.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1097/LBR.0000000000000693DOI Listing

Myeloid diseases in the lung and pleura.

Semin Diagn Pathol 2020 Jun 12. Epub 2020 Jun 12.

Department of Pathology, UT Southwestern Medical Center, BioCenter EB3.234, 2330 Inwood Road, EB3.234, Dallas, TX 75390-9317, USA. Electronic address:

Myeloid diseases detected as primary or secondary lesions in the lung and pleura are rare. Clinical presentations and radiographic results may vary significantly depending on the nature of the diseases. The most common diseases associated with lung and pleura involvement are myeloid sarcoma/acute myeloid leukemia (AML) and extramedullary hematopoiesis (EMH). Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1053/j.semdp.2020.06.002DOI Listing

Diagnostic and Therapeutic Considerations for Extramedullary Leukemia.

Curr Oncol Rep 2020 Jun 24;22(7):75. Epub 2020 Jun 24.

Department of Radiation Oncology, Memorial Sloan Kettering Cancer Center, New York, NY, USA.

Purpose Of Review: The purpose of this review is to summarize the current literature on the presentation, diagnosis, and treatment options available for extramedullary (EM) manifestations of leukemia including myeloid sarcoma (MS) and leukemia cutis (LC).

Recent Findings: Advanced imaging using 18FDG-PET/CT is an effective screening tool for EM manifestations of leukemia. The role of radiation therapy has been more clearly delineated in the treatment of both MS and LC. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1007/s11912-020-00919-6DOI Listing

Gastric myeloid sarcoma with rapid growth.

Dig Endosc 2020 Jun 22. Epub 2020 Jun 22.

Department of Medicine and Clinical Science, Graduate School of Medical Sciences, Kyushu University, Fukuoka, Japan.

A 38-year-old man was referred to our hospital for epigastric pain. His symptom had continued more than a month. Physical examination revealed no abdominal tenderness. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1111/den.13776DOI Listing

Granulocytic sarcoma causing long spinal cord compression: Case report and literature review.

J Spinal Cord Med 2020 Jun 16:1-5. Epub 2020 Jun 16.

Department of Neurosurgery, Peking Union Medical College Hospital, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing, People's Republic of China.

Granulocytic sarcoma (GS) is an extramedullary form of proliferating myeloblasts. It is frequently reported in patients with acute myeloid leukemia (AML) but rarely in patients with chronic myeloid leukemia (CML). Spinal cord compression caused by CML-associated GS is exceedingly rare, with only few cases reported in the literature. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1080/10790268.2020.1771506DOI Listing

Rewired functional regulatory networks among miRNA isoforms (isomiRs) from let-7 and miR-10 gene families in cancer.

Comput Struct Biotechnol J 2020 13;18:1238-1248. Epub 2020 May 13.

Department of Bioinformatics, Smart Health Big Data Analysis and Location Services Engineering Lab of Jiangsu Province, School of Geographic and Biologic Information, Nanjing University of Posts and Telecommunications, Nanjing, China.

Classical microRNA (miRNA) has been so far believed as a single sequence, but it indeed contains multiple miRNA isoforms (isomiR) with various sequences and expression patterns. It is not clear whether these diverse isomiRs have potential relationships and whether they contribute to miRNA:mRNA interactions. Here, we aimed to reveal the potential evolutionary and functional relationships of multiple isomiRs based on let-7 and miR-10 gene families that are prone to clustering together on chromosomes. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1016/j.csbj.2020.05.001DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7280754PMC

Extramedullary disease in acute promyelocytic leukaemia: A rare presentation.

SAGE Open Med Case Rep 2020 2;8:2050313X20926076. Epub 2020 Jun 2.

Department of Hematology, Ampang Hospital, Ampang, Malaysia.

Acute promyelocytic leukaemia consists of 7%-8% of cases of acute myeloid leukaemia. Extramedullary manifestations are rare and show distinct biological features. We describe a 22-year-old female of Malay ethnicity who presented with fever and a left axillary swelling for a week. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1177/2050313X20926076DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7268156PMC

Pancreatic Myeloid Sarcoma.

Cureus 2020 Jun 5;12(6):e8462. Epub 2020 Jun 5.

Internal Medicine, University of Kansas School of Medicine, Wichita, USA.

Myeloid sarcoma is an isolated extramedullary tumor mass consisting of immature myeloid cells. It is characterized by highly variable outcomes and usually disrupts the normal architecture of the normal tissue in which it originates. It may occur de novo or be associated with other hematological malignancies. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.7759/cureus.8462DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7279692PMC

Donor-derived acute promyelocytic leukemia presenting as myeloid sarcoma in a transplanted kidney.

Leukemia 2020 Jun 10. Epub 2020 Jun 10.

Division of Hematology, Department of Medicine, University of Washington and Clinical Research Division, Fred Hutchinson Cancer Research Center, Seattle, WA, USA.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1038/s41375-020-0903-0DOI Listing
June 2020
10.431 Impact Factor

Myeloid Sarcomas Causing Unilateral Cranial Nerve Palsies in a Patient with Relapsed Acute Myeloblastic Leukemia.

Case Rep Hematol 2020 13;2020:3749565. Epub 2020 Jan 13.

Department of Hematology and Oncology, Alton Memorial Hospital, Alton, IL, USA.

Myeloid sarcomas (MS) are a rare manifestation of myeloid malignancies and can often be misdiagnosed, leading to a delay in treatment. The objective of this clinical case is to highlight the challenges of the clinical presentation and to emphasize the importance of this manifestation ensuring timely diagnosis and therapy. Here, we present a 43-year-old man who was diagnosed with acute myeloblastic leukemia (AML) after being evaluated for unintentional weight loss, subcutaneous nodules, thrombocytopenia, and anemia. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1155/2020/3749565DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7201833PMC
January 2020

[High Expression Level of SP1, CSF1R, and PAK1 Correlates with Sensitivity of Leukemia Cells to the Antibiotic Mithramycin].

Mol Biol (Mosk) 2020 May-Jun;54(3):522-528

Engelhardt Institute of Molecular Biology Russian Academy of Sciences, Moscow, 119991 Russia.

Acute myeloid leukemia (AML) is a genetically heterogeneous group of oncological diseases of the hematopoietic system, which are extremely difficult to treat. The development of new targeted drugs (Hylteritinib, Venetoclax) significantly improved the survival of patients, but resistance, as well as cytotoxic anti-leukemia drugs, often occurs. The search for new molecular targets for the development of effective approaches for the treatment of AML is very urgent. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.31857/S0026898420030192DOI Listing
January 2020

Granulocytic/myeloid sarcoma with trisomy 21 presented as an epididymal tumor: A case report and review of the literature.

SAGE Open Med Case Rep 2020 28;8:2050313X20919228. Epub 2020 Apr 28.

Department of Urology, Uonuma Institute of Community Medicine, Niigata University Medical and Dental Hospital, Niigata, Japan.

Myeloid sarcoma is an extramedullary tumor composed of immature myeloid cells and occurs in various extramedullary sites. We report a 48-year-old man diagnosed with myeloid sarcoma in the epididymis. He was admitted to our hospital due to a painless right intrascrotal mass. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1177/2050313X20919228DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7234348PMC

Epidural myeloid sarcoma as the presenting symptom of chronic myeloid leukemia blast crisis.

Clin Rheumatol 2020 Aug 26;39(8):2453-2459. Epub 2020 May 26.

Department of Internal Medicine, Military Hospital, Tunis El Manar University, Tunis, Tunisia.

Epidural myeloid sarcoma revealing chronic myeloid leukemia is scarce. Herein, we describe a patient that presented with back pain and bilateral sciatica secondary to root compression due to epidural deposition of leukemic cells. The magnetic resonance imaging showed epidural masses, causing a slight restriction of the spinal canal with bilateral L5 root compression. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1007/s10067-020-05167-4DOI Listing

Distinct Tumor Microenvironments Are a Defining Feature of Strain-Specific CRISPR/Cas9-Induced MPNSTs.

Genes (Basel) 2020 May 23;11(5). Epub 2020 May 23.

Department of Internal Medicine, University of Iowa, Iowa City, IA 52242, USA.

The tumor microenvironment plays important roles in cancer biology, but genetic backgrounds of mouse models can complicate interpretation of tumor phenotypes. A deeper understanding of strain-dependent influences on the tumor microenvironment of genetically-identical tumors is critical to exploring genotype-phenotype relationships, but these interactions can be difficult to identify using traditional Cre/loxP approaches. Here, we use somatic CRISPR/Cas9 tumorigenesis approaches to determine the impact of mouse background on the biology of genetically-identical malignant peripheral nerve sheath tumors (MPNSTs) in four commonly-used inbred strains. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.3390/genes11050583DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7288323PMC

Primary spinal intramedullary Ewing-like sarcoma harboring CIC-DUX4 translocation: a similar cytological appearance as its soft tissue counterpart but no lobulation in association with desmoplastic stroma.

Brain Tumor Pathol 2020 Jul 24;37(3):111-117. Epub 2020 May 24.

Department of Pathology, Fujita Health University School of Health Sciences, Toyoake, Aichi, Japan.

The CIC-DUX4 translocation is the most common genetic alteration of small round cell sarcomas without EWSR1 rearrangement. These "Ewing-like sarcomas" usually occur in peripheral soft tissues, and rare primary central nervous system (CNS) tumors have been described. We report a rare case of primary spinal intramedullary Ewing-like sarcoma harboring CIC-DUX4 translocation. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1007/s10014-020-00366-yDOI Listing

Review on gall bladder myeloid sarcoma: a great masquerader.

Chin Clin Oncol 2020 Jun 20;9(2):37. Epub 2020 May 20.

Hemato-Oncology Division, Department of Internal Medicine, Saint Vincent Hospital, Worcester, MA, USA.

Pain in abdomen has wide differentials and narrowing down the clinical possibilities depends on type of pain, location, characterization which is usually assisted by imaging studies. Cholecystitis and cholelithiasis are amongst the common causes of acute abdomen. This study reviews the literature for the clinical characteristics, differential diagnosis, treatment and prognosis of reported cases of gallbladder myeloid sarcoma (GB-MS) who presented with abdominal symptoms. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.21037/cco-19-250DOI Listing

A novel and successful therapeutic approach in the treatment of a patient with simultaneous relapsed Ewing sarcoma and therapy-related acute myeloid leukemia.

Pediatr Blood Cancer 2020 Jul 19;67(7):e28240. Epub 2020 May 19.

Division of Pediatric Hematology/Oncology, Nemours Center for Cancer and Blood Disorders, Nemours Alfred I. duPont Hospital for Children, Wilmington, Delaware.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1002/pbc.28240DOI Listing

Temporal region myeloid sarcoma: When to suspect and how to approach?

Oral Maxillofac Surg 2020 May 12. Epub 2020 May 12.

Department of Medical Oncology, Division of Hematologic Malignancies, Dana-Farber Cancer Institute, Harvard Medical School, Boston, MA, USA.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1007/s10006-020-00847-6DOI Listing

Reply to Letter to the Editor commenting on the article "Myeloid sarcoma on the temporal region before the onset of the acute myeloid leukemia: an extremely rare case report".

Oral Maxillofac Surg 2020 May 7. Epub 2020 May 7.

Department of Oral & Maxillofacial Surgery, Traumatology and Prosthesis - Faculty of Dentistry of the University of São Paulo, São Paulo, Brazil.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1007/s10006-020-00848-5DOI Listing

Characteristics of myeloid sarcoma in mice and patients with deficiency.

Oncol Lett 2020 Jun 27;19(6):3789-3798. Epub 2020 Mar 27.

Department of Hematology, Tianjin Medical University Cancer Institute and Hospital, National Clinical Research Center for Cancer, Key Laboratory of Cancer Prevention and Therapy, Tianjin's Clinical Research Center for Cancer, Tianjin 300060, P.R. China.

Myeloid sarcoma (MS) carries a poor prognosis, and information on epigenetic modifications in MS is currently limited. In the present study, 214 ten-eleven translocation-2 () mice were successfully constructed. In addition, 436 patients with myelodysplastic syndrome (MDS) and 354 with acute myeloid leukemia (AML) patients were recruited. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.3892/ol.2020.11479DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7202316PMC

Chronic phase of chronic myeloid leukemia presenting with myeloid sarcoma in an adolescent.

Blood Res 2020 Jun;55(2):112-115

Departments of Pediatrics, College of Medicine, Yeungnam University, Daegu, Korea.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.5045/br.2020.2019191DOI Listing

Uterine myeloid sarcoma.

Ann Hematol 2020 Jul 4;99(7):1671-1672. Epub 2020 May 4.

Department of Experimental Medicine-Section of Pathologic Anatomy and Histology Medical School, University of Perugia, Perugia, Italy.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1007/s00277-020-04065-8DOI Listing

[Myeloid sarcoma].

Rofo 2020 Apr 30. Epub 2020 Apr 30.

Diagnostic and Interventional Radiology, University Hospital Magdeburg, Germany.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1055/a-1150-8131DOI Listing

Isolated intracranial myeloid sarcoma: report of a case and review of the literature.

Br J Neurosurg 2020 Apr 30:1-4. Epub 2020 Apr 30.

Department of Neurosurgery, Policlinico Tor Vergata, Rome, Italy.

Myeloid sarcoma is a rare malignant tumor of primitive myeloid cell origin often associated with hematologic disorders. The central nervous system is rarely involved and differentiating between myeloid sarcoma and other tumors is not possible on imaging. Here we present the rare case of an isolated intracranial myeloid sarcoma, initially misdiagnosed radiologically as a meningioma, treated with surgical total resection and subsequent chemotherapy, with no signs of any hematological disorder at follow up. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1080/02688697.2020.1759782DOI Listing

Mutations within the Activation Loop Domain of FLT3 in Two Pediatric Patients with Refractory Infant Acute Myeloid Leukemia.

Case Rep Oncol 2020 Jan-Apr;13(1):266-270. Epub 2020 Mar 24.

Division of Pediatric Hematology/Oncology, Brown University/Hasbro Children's Hospital, Providence, Rhode Island, USA.

Approximately 24% of all pediatric acute myeloid leukemia (AML) cases have mutations in the FMS-like tyrosine kinase 3 () receptor gene. FLT3-TKD point mutations are rare in pediatrics and often occur in younger patients and in combination with 11q23 abnormalities. There is a paucity of data related to their prognostic implications in children. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1159/000506194DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7154245PMC

Placental myeloid sarcoma.

Blood 2020 Apr;135(16):1410

University and Hospital of Perugia.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1182/blood.2020004975DOI Listing

Cancer risk following lymphoid malignancies among HIV-infected people.

AIDS 2020 07;34(8):1237-1245

Radiation Epidemiology Branch, Division of Cancer Epidemiology and Genetics, Department of Health and Human Services, National Cancer Institute, National Institutes of Health, Bethesda, Maryland, USA.

Objective(s): HIV-infected people have increased cancer risk. Lymphoma survivors have an increased risk of certain second primary cancers in the general population, but second cancer risk among HIV-infected people is poorly understood. Herein, we characterized the risk of cancers following lymphoid malignancies among HIV-infected people. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1097/QAD.0000000000002528DOI Listing
July 2020
5.554 Impact Factor

Somatic ASXL1 p.R693X mutation identified by next generation sequencing in isolated myeloid sarcoma involving the mediastinum.

Curr Med Res Opin 2020 Jun 14;36(6):1003-1007. Epub 2020 Apr 14.

MDS and MPN Center, Institute of Hematology and Blood Diseases Hospital, Chinese Academy of Medical Sciences and Peking Union Medical College, Tianjin, China.

Isolated myeloid sarcoma (MS) is characterized by extramedullary immature myeloid cell infiltration without bone marrow involvement. The diagnosis of isolated MS is sometimes difficult in cases without expression of typical immunohistochemical markers, such as CD64, MPO or lysozyme. We report a case of isolated MS involving the mediastinum, with negative staining of MPO and lysozyme, which was misdiagnosed for 20 months. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1080/03007995.2020.1744121DOI Listing

PreMSIm: An R package for predicting microsatellite instability from the expression profiling of a gene panel in cancer.

Comput Struct Biotechnol J 2020 19;18:668-675. Epub 2020 Mar 19.

Biomedical Informatics Research Lab, School of Basic Medicine and Clinical Pharmacy, China Pharmaceutical University, Nanjing 211198, China.

Microsatellite instability (MSI) is a genomic property of the cancers with defective DNA mismatch repair and is a useful marker for cancer diagnosis and treatment in diverse cancer types. In particular, MSI has been associated with the active immune checkpoint blockade therapy response in cancer. Most of computational methods for predicting MSI are based on DNA sequencing data and a few are based on mRNA expression data. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1016/j.csbj.2020.03.007DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7113609PMC

The first case of acute myeloid leukaemia/myeloid sarcoma with cytokeratin expression on blasts diagnosed on urine specimen.

Hematol Oncol Stem Cell Ther 2020 Mar 18. Epub 2020 Mar 18.

Haematology Department, Cork University Hospital, Cork, Ireland. Electronic address:

Here we describe a rare case of renal myeloid sarcoma, first discovered incidentally on routine urine analysis, which is one of the first of it's kind to be reported. We describe the vanishingly rare phenomenon of renal myeloid sarcoma presenting without haematological manifestation while also highlighting the often inevitable transformative nature of the disease. We also describe the unusual immunohistochemistry findings, in particular the cytokeratin expression, that is not usually typical of such cases. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1016/j.hemonc.2020.02.007DOI Listing

Phase I Study of the Mutant IDH1 Inhibitor Ivosidenib: Safety and Clinical Activity in Patients With Advanced Chondrosarcoma.

J Clin Oncol 2020 May 24;38(15):1693-1701. Epub 2020 Mar 24.

Sylvester Comprehensive Cancer Center, University of Miami, Miami, FL.

Purpose: Surgery is the primary therapy for localized chondrosarcoma; for locally advanced and/or metastatic disease, no known effective systemic therapy exists. Mutations in the isocitrate dehydrogenase 1/2 (IDH1/2) enzymes occur in up to 65% of chondrosarcomas, resulting in accumulation of the oncometabolite D-2-hydroxyglutarate (2-HG). Ivosidenib (AG-120) is a selective inhibitor of mutant IDH1 approved in the United States for specific cases of acute myeloid leukemia. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1200/JCO.19.02492DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7238491PMC

An Unusual Cause of Post-Polypectomy Bleeding.

Gastroenterology 2020 Mar 20. Epub 2020 Mar 20.

Department of Medicine, Texas Health Presbyterian Hospital of Dallas; Texas Digestive Disease Consultants, Dallas, Texas.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1053/j.gastro.2020.02.063DOI Listing

Aleukemia cutis: Clinicopathological and molecular investigation of two cases.

J Cutan Pathol 2020 Mar 20. Epub 2020 Mar 20.

Department of Pathology, Imam Khomeini Hospital, Tehran University of Medical Sciences, Tehran, Iran.

We describe two cases of acute myeloid leukemia (AML) who presented with cutaneous manifestations. Leukemia cutis (LC) is the cutaneous presentation of any type of leukemia and occurs in 10% to 15% of patients with AML, but cutaneous infiltration of AML rarely precedes the involvement of the bone marrow or peripheral blood and is called as "aleukemia cutis." Our first case presented with facial skin thickening, a manifestation which is known as lionization and his initial clinical diagnosis was nonspecific allergic reaction. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1111/cup.13690DOI Listing
March 2020
1.560 Impact Factor

[Clinicopathological features of myeloid sarcoma and DLBCL in the breast: a comparative study].

Zhonghua Bing Li Xue Za Zhi 2020 Mar;49(3):250-255

Department of Pathology, Peking University People's Hospital, Beijing 100044, China.

To study the clinicopathological features, diagnosis and differential diagnosis of myeloid sarcoma of the breast. Ten cases of myeloid sarcoma (MS) and 19 cases of diffuse large B cell lymphoma (DLBCL) of the breast were selected from Peking University People's Hospital from February 2005 to September 2019. The cases were evaluated by microscopy and immunohistochemistry basing on WHO classification (2008 and 2017). Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.3760/cma.j.issn.0529-5807.2020.03.008DOI Listing

Successful treatment with gilteritinib for isolated extramedullary relapse of acute myeloid leukemia with FLT3-ITD mutation after allogeneic stem cell transplantation.

Int J Hematol 2020 Mar 13. Epub 2020 Mar 13.

Department of Hematology, National Hospital Organization, Kure Medical Center and Chugoku Cancer Center, 3-1 Aoyama-chou, Kure, Hiroshima, 737-0023, Japan.

Acute myeloid leukemia (AML) harboring Fms-like tyrosine kinase 3 (FLT3) internal tandem duplication (ITD) mutation is associated with shorter remission and higher relapse risk. Several FLT3 inhibitors have been used in clinical trials, but their efficacy in extramedullary disease remains unclear. In the present case, a 56-year-old man was diagnosed with FLT3-ITD mutated AML. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1007/s12185-020-02855-4DOI Listing

Tumor-Derived Retinoic Acid Regulates Intratumoral Monocyte Differentiation to Promote Immune Suppression.

Cell 2020 Mar 12;180(6):1098-1114.e16. Epub 2020 Mar 12.

Department of Pathology and Laboratory Medicine, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA 19014, USA; Abramson Family Cancer Research Institute, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA 19104, USA; Institute for Immunology, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA 19104, USA. Electronic address:

The immunosuppressive tumor microenvironment (TME) is a major barrier to immunotherapy. Within solid tumors, why monocytes preferentially differentiate into immunosuppressive tumor-associated macrophages (TAMs) rather than immunostimulatory dendritic cells (DCs) remains unclear. Using multiple murine sarcoma models, we find that the TME induces tumor cells to produce retinoic acid (RA), which polarizes intratumoral monocyte differentiation toward TAMs and away from DCs via suppression of DC-promoting transcription factor Irf4. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1016/j.cell.2020.02.042DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7194250PMC

Hematolymphoid Neoplasms Rarely Mimic Undifferentiated Pleomorphic Sarcoma of Soft Tissue.

Arch Pathol Lab Med 2020 Mar 13. Epub 2020 Mar 13.

From the Departments of Pathology (Drs Cannatella and Horvai) and Laboratory Medicine (Dr Ganapathi), University of California, San Francisco, San Francisco. Dr Cannatella is now with the Department of Pathology, University of Arkansas for Medical Sciences, Little Rock.

Context.—: Undifferentiated pleomorphic sarcoma (UPS) of soft tissue is defined as a sarcoma with no recognizable line of differentiation. During the past few decades, advances in ancillary studies and review of prior UPS diagnoses have narrowed the category of UPS by excluding more-specific malignancies. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.5858/arpa.2019-0580-OADOI Listing

An Iridociliochoroidal Myeloid Sarcoma Associated With Relapsed Acute Myeloid Leukemia With FLT3-ITD Mutation, Treated With Gilteritinib, an FLT3 Inhibitor.

JAMA Ophthalmol 2020 Mar 12. Epub 2020 Mar 12.

Ocular Oncology Service, Wills Eye Hospital, Thomas Jefferson University, Philadelphia, Pennsylvania.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1001/jamaophthalmol.2020.0110DOI Listing

Interleukin-1 Receptor-Associated Kinase (IRAK) Signaling in Kaposi Sarcoma-Associated Herpesvirus-Induced Primary Effusion Lymphoma.

J Virol 2020 May 4;94(10). Epub 2020 May 4.

Department of Microbiology and Immunology, Center for AIDS Research, Lineberger Comprehensive Cancer Center, University of North Carolina at Chapel Hill, Chapel Hill, North Carolina, USA

Kaposi sarcoma-associated herpesvirus (KSHV) is necessary but not sufficient for primary effusion lymphoma (PEL) development. Alterations in cellular signaling pathways are also a characteristic of PEL. Other B cell lymphomas have acquired an oncogenic mutation in the myeloid differentiation primary response 88 (MYD88) gene. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1128/JVI.02123-19DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7199399PMC

Validation of miR-20a as a Tumor Suppressor Gene in Liver Carcinoma Using Hepatocyte-Specific Hyperactive piggyBac Transposons.

Mol Ther Nucleic Acids 2020 Mar 22;19:1309-1329. Epub 2020 Jan 22.

Department of Gene Therapy & Regenerative Medicine, Vrije Universiteit Brussel, 1090 Brussels, Belgium; Center for Molecular & Vascular Biology, Department of Cardiovascular Sciences, University of Leuven, 3000 Leuven, Belgium. Electronic address:

We established a semi-high-throughput in vivo screening platform using hyperactive piggyBac (hyPB) transposons (designated as PB-miR) to identify microRNAs (miRs) that inhibit hepatocellular carcinoma (HCC) development in vivo, following miR overexpression in hepatocytes. PB-miRs encoding six different miRs from the miR-17-92 cluster and nine miRs from outside this cluster were transfected into mouse livers that were chemically induced to develop HCC. In this slow-onset HCC model, miR-20a significantly inhibited HCC. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1016/j.omtn.2020.01.015DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7036702PMC

[Mediastinal abscess due to Aspergillus in a patient with atypical chronic myeloid leukemia, BCR-ABL1-negative].

Rinsho Ketsueki 2020 ;61(2):128-130

Department of Hematology, Gunma University Graduate School of Medicine.

A 64-year-old male presented with a rapidly growing anterior mediastinal mass during the clinical course of atypical chronic myeloid leukemia. A needle biopsy performed for suspected myeloid sarcoma revealed the presence of Aspergillus abscess. Early diagnosis of mediastinal abscesses, which are associated with a high mortality rate, can prevent the progression of severity. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.11406/rinketsu.61.128DOI Listing

Cutaneous Myeloid Sarcoma.

Authors:
Shuku Sato

Intern Med 2020 1;59(5):755-756. Epub 2020 Mar 1.

Division of Hematology, Shonan Kamakura General Hospital, Japan.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.2169/internalmedicine.3560-19DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7086320PMC

[Clinicopathological features of T-lymphoblastic lymphoma with Langerhans cell histiocytosis in the same lymph node].

Zhonghua Bing Li Xue Za Zhi 2020 Feb;49(2):149-155

Department of Pathology, Beijing Friendship Hospital, Capital Medical University, Beijing 100050, China.

To investigate the clinicopathological features, immunophenotypes, genetics and prognosis of T-lymphocyte lymphoma/myeloid sarcoma combined with Langerhans cell histiocytyosis (coexistence of T-LBL/MS and LCH). Clinical and pathological data of the 6 patients with coexistence of T-LBL/MS and LCH were analyzed, who were diagnosed at the Foshan Hospital of Sun Yat-sen University and the Friendship Hospital of Capital Medical University, from December 2013 to April 2019. The hematoxylin and eosin stain, immunohitochemistry (EnVision) and in situ hybridization were used. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.3760/cma.j.issn.0529-5807.2020.02.009DOI Listing
February 2020

Extramedullary blastic transformation of primary myelofibrosis in the form of disseminated myeloid sarcoma: a case report and review of the literature.

Clin Exp Med 2020 May 17;20(2):313-320. Epub 2020 Feb 17.

CRIMM, Center of Research and Innovation of Myeloproliferative Neoplasms, Azienda Ospedaliero-Universitaria Careggi, 50134, Florence, Italy.

Splenomegaly is a key clinical manifestation of myelofibrosis, and splenectomy is currently indicated in patients with drug refractory, symptomatic splenomegaly or with the aim of improving refractory cytopenias. Transformation to acute myeloid leukemia occurs in up to 20% of patients with myelofibrosis, while cases of myeloid sarcoma have been reported very unfrequently. In this manuscript, we report the case of a 60-year-old man with a history of primary myelofibrosis who underwent splenectomy because of drug-refractory massive splenomegaly, systemic symptoms and anemia. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1007/s10238-020-00616-5DOI Listing

Integrin α7 and Extracellular Matrix Laminin 211 Interaction Promotes Proliferation of Acute Myeloid Leukemia Cells and Is Associated with Granulocytic Sarcoma.

Cancers (Basel) 2020 Feb 5;12(2). Epub 2020 Feb 5.

Department of Hematology, Gunma University Graduate School of Medicine, Maebashi 371-8510, Japan.

Acute myeloid leukemia (AML) with granulocytic sarcoma (GS) is characterized by poor prognosis; however, its underlying mechanism is unclear. Bone marrow samples from 64 AML patients (9 with GS and 55 without GS) together with AML cell lines PL21, THP1, HL60, Kasumi-1, and KG-1 were used to elucidate the pathology of AML with GS. RNA-Seq analyses were performed on samples from seven AML patients with or without GS. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.3390/cancers12020363DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7072541PMC
February 2020

Myeloid sarcoma of the tongue as a first manifestation of acute promyelocytic leukemia: A case report.

Rep Pract Oncol Radiother 2020 Mar-Apr;25(2):174-177. Epub 2020 Jan 9.

Pathological Anatomy Service, Hospital Nacional Alberto Sabogal Sologuren, Lima, Peru.

Introduction: We describe a 35-year-old male patient showing a myeloid sarcoma (MS) of the tongue as the first manifestation of acute promyelocytic leukemia (APL). The MS can appear in all parts of the human body, but it is extremely rare in the tongue.

Clinical Case: The main symptoms were a pain in the tongue, asthenia, gingivorrhagia, fever. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1016/j.rpor.2019.12.026DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6994280PMC
January 2020

Urgent Chemotherapy Successfully Rescues a Near Death Patient of Acute Intracranial Hypertension Caused by Intracranial Myeloid Sarcoma.

Onco Targets Ther 2020 9;13:237-241. Epub 2020 Jan 9.

Department of Hematology, The First Affiliated Hospital of USTC, Division of Life Sciences and Medicine, University of Science and Technology of China, Hefei, People's Republic of China.

Intracranial myeloid sarcoma is a very rare disease with poor prognosis. We report a case of a 28-year-old male patient who was admitted with intense headache, vision disturbance and severe vomiting in June 2017. He had a history of neurosurgical tumor resection operation in April 2017, and the pathological diagnosis was intracranial myeloid sarcoma. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.2147/OTT.S230478DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6957092PMC
January 2020