6,922 results match your criteria Mycosis Fungoides


Multi-institutional Investigation: Circulating CD4:CD8 ratio is a prognosticator of response to total skin electron beam radiation in mycosis fungoides.

Radiother Oncol 2019 Feb 31;131:88-92. Epub 2018 Dec 31.

Department of Radiation Oncology, The University of Texas MD Anderson Cancer Center, United States. Electronic address:

Background And Purpose: A lower proportion of CD8+ tumor infiltrating lymphocytes in mycosis fungoides (MF) patients is associated with worse survival. However, it is not known whether circulating CD4:CD8 ratio is a prognosticator of response to total skin electron beam therapy (TSEBT).

Methods And Materials: We identified 126 MF patients treated with TSEBT from 2001 to 20014 at two high-volume academic centers. Read More

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http://dx.doi.org/10.1016/j.radonc.2018.12.003DOI Listing
February 2019

Progression of mycosis fungoides occurs through divergence of tumor immunophenotype by differential expression of HLA-DR.

Blood Adv 2019 Feb;3(4):519-530

Instititute of Immunology and Immunotherapy, University of Birmingham, Birmingham, United Kingdom; and.

Immunotherapy is a valuable treatment for many cancer patients, and there is considerable interest in understanding the mechanisms of immune evasion to guide appropriate management. Mycosis fungoides (MF) is a malignant disorder of skin-homing CD4 T cells, and it exhibits a highly variable clinical course during which the tumor-specific immune response may be an important determinant. An unusual feature of MF is that tumor-infiltrating lymphocytes (TILs) must attempt to control a malignant cell from within their own lineage. Read More

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http://dx.doi.org/10.1182/bloodadvances.2018025114DOI Listing
February 2019

The impact of environmental UV exposure on the clinical course of Mycosis Fungoides.

J Am Acad Dermatol 2019 Feb 11. Epub 2019 Feb 11.

Department of Hematology, MedStar Washington Hospital Center, 110 Irving St, Washington DC, 20010.

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http://dx.doi.org/10.1016/j.jaad.2019.02.010DOI Listing
February 2019

Mycosis fungoides, Psoriasis und PD-1-Inhibitoren - neuer Aspekt einer bekannten Assoziation.

J Dtsch Dermatol Ges 2019 Feb;17(2):186-188

Dermatology Service, Department of Medicine, Memorial Sloan Kettering Cancer Center, and Weill Cornell Medicine, New York, NY, USA.

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http://dx.doi.org/10.1111/ddg.13715_gDOI Listing
February 2019

Influence of the phenotype on mycosis fungoides prognosis, a retrospective cohort study of 160 patients.

Int J Dermatol 2019 Feb 14. Epub 2019 Feb 14.

Division of Dermatology, Department of Medicine, Sunnybrook Health Sciences Centre, Toronto, Canada.

Background: Mycosis fungoides (MF) typically has a CD4 CD8 T-cell phenotype. Rare cases of CD4 CD8 , CD4 CD8 , or CD4 CD8 immunophenotypes have been described. Little is known about the impact of MF immunophenotypes on disease behavior. Read More

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http://doi.wiley.com/10.1111/ijd.14391
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http://dx.doi.org/10.1111/ijd.14391DOI Listing
February 2019
4 Reads

Comparison of low-dose and standard-dose total skin electron beam therapy in mycosis fungoides.

Leuk Lymphoma 2019 Feb 14:1-3. Epub 2019 Feb 14.

a Department of Radiation Oncology , Virginia, Commonwealth University Health System, Massey Cancer Center.

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http://dx.doi.org/10.1080/10428194.2019.1574008DOI Listing
February 2019
1 Read

Prognostic Significance of Serum Copper in Patients With Cutaneous T-cell Lymphoma.

Clin Lymphoma Myeloma Leuk 2019 Jan 2. Epub 2019 Jan 2.

University of Arizona, Tucson, AZ.

Background: Serum copper has been reported to be increased in various cancers, including lymphoma. The purpose of the present study was to investigate the clinical and prognostic importance of serum copper levels in patients with cutaneous T-cell lymphoma (CTCL).

Patients And Methods: Serum copper was measured in 60 men and 38 women with mycosis fungoides (MF) and 14 men and 3 women with erythrodermic CTCL (6 with Sézary syndrome) consecutively evaluated from July 1980 to June 1985. Read More

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https://linkinghub.elsevier.com/retrieve/pii/S21522650183144
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http://dx.doi.org/10.1016/j.clml.2018.12.020DOI Listing
January 2019
5 Reads

Paraneoplastic scleroderma in the setting of CD30 large cell transformation of mycosis fungoides.

JAAD Case Rep 2019 Feb 31;5(2):201-204. Epub 2019 Jan 31.

Columbia University Medical Center, Department of Dermatology, New York, New York.

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http://dx.doi.org/10.1016/j.jdcr.2018.11.014DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6357550PMC
February 2019
1 Read

Plamacytoid dendritic cells in granulomatous variant of mycosis fungoides.

J Cutan Pathol 2019 Feb 7. Epub 2019 Feb 7.

Los Angeles Medical Center (LAMC), Southern California Kaiser Permanente, Department of Dermatology, Los Angeles, California,, USA.

Introduction: Granulomatous mycosis fungoides (MF) is a rare variant in which granulomas are associated with other typical signs of MF. Its prognosis is worse than that of classical MF. Plasmacytoid dendritic cells (PDC) are a subset of Interferon (IFN) producing dendritic cells that link the innate and the adaptative immune responses. Read More

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http://dx.doi.org/10.1111/cup.13438DOI Listing
February 2019
1 Read

Oral mycosis fungoides with CD30 large cell transformation successfully treated with brentuximab vedotin.

JAAD Case Rep 2019 Feb 30;5(2):180-183. Epub 2019 Jan 30.

Georgetown University School of Medicine, Department of Dermatology, Washington, DC.

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https://linkinghub.elsevier.com/retrieve/pii/S23525126183034
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http://dx.doi.org/10.1016/j.jdcr.2018.11.013DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6357896PMC
February 2019
2 Reads

Lymphoprolipherative skin reactions induced by anti-TNFα: An open question.

J Dermatolog Treat 2019 Feb 6:1-14. Epub 2019 Feb 6.

a 1st Department of Dermatology "Andreas Syggros" Hospital, Medical School, National and Kapodistrian University of Athens , Athens , Greece.

Although anti-TNFα agents have revolutionized the treatment of many inflammatory diseases, various concerns have been reported regarding the risks of cancer development, as well as acceleration of the progression of subclinical, pre-existing malignancies. In this case series we investigated the provocative effect of anti-TNFα drugs in the development of cutaneous mycosis fungoides (MF)-like lymphoproliferative reactions. We describe 5 patients aged between 25-63 diagnosed with autoimmune disorders (psoriatic arthritis- one patient, Crohn's disease- one patient and ankylosing spondylitis- three patients) who received anti-TNFα agents before the development of a cutaneous lymphoproliferative reaction. Read More

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http://dx.doi.org/10.1080/09546634.2019.1579889DOI Listing
February 2019
1 Read

Follicular mucinosis in patients with hematologic malignancies other than mycosis fungoides: A clinicopathologic study.

J Am Acad Dermatol 2019 Feb 1. Epub 2019 Feb 1.

Department of Pathology, Memorial Sloan Kettering Cancer Center and Weill Cornell Medical College, New York, NY, USA.

Background: Follicular mucinosis (FM), defined by mucin accumulation within follicular epithelium, may occur in mycosis fungoides (MF). FM without MF is occasionally reported in systemic hematologic malignancies, and may be diagnostically challenging.

Objective: To describe clinicopathological characteristics of FM in patients with hematologic malignancies other than MF. Read More

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http://dx.doi.org/10.1016/j.jaad.2019.01.062DOI Listing
February 2019
1 Read

Does continuous subcutaneous infusion of lignocaine relieve intractable pruritus associated with advanced cutaneous T-cell lymphoma? A retrospective case series review.

Palliat Med 2019 Feb 4:269216319828189. Epub 2019 Feb 4.

4 Division of Palliative Care, Peter MacCallum Cancer Centre, Victorian Comprehensive Cancer Centre, Melbourne, VIC, Australia.

Background:: Intractable pruritus affects an estimated 83% of patients with advanced cutaneous T-cell lymphoma. Palliative care strategies to improve outcomes for these patients are lacking. Lignocaine antagonises kappa opioid antagonist-induced scratching in mice models and may relieve cutaneous T-cell lymphoma-pruritus. Read More

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http://journals.sagepub.com/doi/10.1177/0269216319828189
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http://dx.doi.org/10.1177/0269216319828189DOI Listing
February 2019
5 Reads

[Necrotic leg ulcers after topical application of chlormethine].

Ann Dermatol Venereol 2019 Jan 28. Epub 2019 Jan 28.

Service de médecine vasculaire, groupe hospitalier Paris Saint-Joseph, 185, rue Raymond-Losserand, 75014 Paris, France.

Background: Topical chlormethine has been widely used in the early stages of mycosis fungoides for many years. Cutaneous reactions (skin irritation and itch) are the most frequent adverse effects. Herein we report a rare side effect: severe necrotic leg ulcers. Read More

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http://dx.doi.org/10.1016/j.annder.2018.12.001DOI Listing
January 2019
1 Read

[Skin follicular mycosis fungoides: one case report].

Zhonghua Xue Ye Xue Za Zhi 2019 Jan;40(1):77

Department of Clinical Medicine, the Affiliated Tumor Hospital of Zhengzhou University, Zhenghou 450008, China.

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http://dx.doi.org/10.3760/cma.j.issn.0253-2727.2019.01.016DOI Listing
January 2019
1 Read

Comparison of Narrowband UV-B With Psoralen-UV-A Phototherapy for Patients With Early-Stage Mycosis Fungoides: A Systematic Review and Meta-analysis.

JAMA Dermatol 2019 Jan 30. Epub 2019 Jan 30.

Department of Dermatology, Liverpool Hospital, Liverpool, Sydney, Australia.

Importance: Phototherapy is one of the mainstays of treatment for early mycosis fungoides (MF). The most common modalities are psoralen-UV-A (PUVA) and narrowband UV-B (NBUVB).

Objective: To compare the efficacy and adverse effects of PUVA vs NBUVB in early-stage MF. Read More

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http://archderm.jamanetwork.com/article.aspx?doi=10.1001/jam
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http://dx.doi.org/10.1001/jamadermatol.2018.5204DOI Listing
January 2019
4 Reads

Hypo-pigmented mycosis fungoides is a rare malignancy in pediatrics.

Dermatol Online J 2018 Nov 15;24(11). Epub 2018 Nov 15.

Hematology Research Center, Shiraz University of Medical Sciences, Shiraz.

Hypopigmented mycosis fungoides (HMF) is an uncommon form of cutaneous T-cell lymphoma. It can be seen in children and is usually mistaken for eczema, vitiligo, or progressive macular hypomelanosis, clinically and histopathologically. We present a boy with HMF confirmed by histopathology. Read More

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November 2018
5 Reads

Immune evasion and current immunotherapy strategies in mycosis fungoides (MF) and Sézary syndrome (SS).

Chin Clin Oncol 2019 Jan 9. Epub 2019 Jan 9.

Department of Dermatology and Cutaneous Biology, Thomas Jefferson University, Philadelphia, PA, USA; Sidney Kimmel Cancer Center at Jefferson Health, Philadelphia, PA, USA.

Mycosis fungoides (MF) and Sézary syndrome (SS) are two well-characterized skin limited and leukemic subtypes of cutaneous T-cell lymphoma (CTCL), respectively. Progressive global immune dysfunction and a multitude of specific immunological abnormalities have long been recognized as features of MF and SS. Therefore, a variety of immune-based therapies have been explored and used in the clinic for decades in the attempt to restore the immune imbalance in these malignancies. Read More

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http://cco.amegroups.com/article/view/23332
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http://dx.doi.org/10.21037/cco.2019.01.01DOI Listing
January 2019
15 Reads

Macular hypopigmentation, hair loss and follicular spongiosis: A distinct clinicopathological entity.

Indian J Dermatol Venereol Leprol 2019 Jan 25. Epub 2019 Jan 25.

Department of Dermatology and Venereology, All India Institute of Medical Sciences, New Delhi, India.

Background: Hypopigmented macules are seen in a variety of disorders and the diagnosis rests on clinicopathological correlation. However, some cases are difficult to classify and pose a diagnostic challenge.

Aim: To describe the clinical and histopathological features of patients with hypopigmented macules and follicular spongiosis on histopathology. Read More

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http://dx.doi.org/10.4103/ijdvl.IJDVL_679_17DOI Listing
January 2019
1 Read

CD30-Positive Angioinvasive Lymphomatoid Papulosis (Type E) Developing from Parapsoriasis en Plaque.

Case Rep Oncol 2018 Sep-Dec;11(3):850-854. Epub 2018 Dec 13.

Department of Dermatology, Tohoku University Graduate School of Medicine, Sendai, Japan.

Angioinvasive lymphomatoid papulosis (LyP) type E is a rare variant characterized by angiocentric and angiodestructive features with CD30+ CD8+ lymphocyte infiltration. In rare cases, LyP type E is concomitant with mycosis fungoides, but there is no English report that describe LyP type E developing from parapsoriasis en plaque. In this report, we described a case of angioinvasive LyP (type E) developing from parapsoriasis en plaque, in which we employed immunohistochemical staining for the investigation of its pathomechanisms. Read More

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http://dx.doi.org/10.1159/000495689DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6341360PMC
December 2018
1 Read

Folliculotropic mycosis fungoides.

Dermatol Online J 2018 Dec 15;24(12). Epub 2018 Dec 15.

The Ronald O. Perelman Department of Dermatology, New York University Langone Health, New York, New York.

Folliculotropic mycosis fungoides (MF) is a distinct subset of cutaneous T cell lymphoma (CTCL). The disease is typically marked by an aggressive course and is often recalcitrant to skin-direct therapy. We report a case of an 83-year-old woman with folliculotropic MF characterized by erythematous, scaly plaques on the forehead along with poliosis and alopecia of the right medial eyebrow. Read More

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December 2018
1 Read

Impressive response of CD30-negative, treatment-refractory mycosis fungoides to brentuximab vedotin.

Dermatol Ther 2019 Jan 19:e12835. Epub 2019 Jan 19.

Department of Dermatology, University of Minnesota, Moffitt Cancer Center, Tampa, Florida.

Brentuximab vedotin is a CD30-antibody/drug conjugate which has demonstrated excellent response in treating CD30-positive mycosis fungoides (MF) and anaplastic large cell lymphoma (ALCL). In this report, we present a patient with CD30-negative MF refractory to multiple other lines of therapy who demonstrated a dramatic response to brentuximab. This paradoxical response may be due to inadequate detection of CD30 expression by immunohistochemical techniques. Read More

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http://dx.doi.org/10.1111/dth.12835DOI Listing
January 2019
2 Reads

Multiple melanocytic nevi restricted to mycosis fungoides patches in pediatric and young-adult patients. The potential role of local immunosuppression.

Pediatr Dermatol 2019 Jan 18. Epub 2019 Jan 18.

Department of Dermatology, Northwestern University, Feinberg School of Medicine, Chicago, Illinois.

We described the development of multiple melanocytic nevi within long-standing MF patches in four young patients. Mycosis fungoides (MF) patches are characterized by a regulatory-like cytokine profile leading to local immune suppression. The proliferation of nevomelanocytes is regulated by cellular senescence mechanisms mediated by immune system. Read More

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http://dx.doi.org/10.1111/pde.13738DOI Listing
January 2019
1 Read

Granulomatous mycosis fungoides responsive to acitretin and UVA1 treatment.

Australas J Dermatol 2019 Jan 17. Epub 2019 Jan 17.

South East Dermatology Stafford, Stafford, Queensland, Australia.

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http://dx.doi.org/10.1111/ajd.12994DOI Listing
January 2019
2 Reads

Mycosis fungoides presenting as vulvar plaques.

J Eur Acad Dermatol Venereol 2019 Jan 17. Epub 2019 Jan 17.

Department of Dermatology, Saint-Louis Hospital, APHP, Paris Diderot University, INSERM U976, Paris, France.

Mycosis fungoides (MF), the most frequent type of cutaneous T-cell lymphoma, is characterized in the early stage by patches and plaques that predominate in sun-protected areas. MF is rarely associated with vulvar involvement. We report two cases of MF with predominant vulvar lesions. Read More

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http://doi.wiley.com/10.1111/jdv.15429
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http://dx.doi.org/10.1111/jdv.15429DOI Listing
January 2019
5 Reads

Low- vs. Middle-dose Total Skin Electron Beam Therapy for Mycosis Fungoides: An Efficiency-based Retrospective Survey of Skin Response.

Acta Derm Venereol 2019 01 17. Epub 2019 Jan 17.

Department of Dermatology, INSERM U1058 University of Montpellier, FR-34295 Montpellier, France.

Optimal doses of total skin electron beam therapy for mycosis fungoides remain to be established. Clinical efficiency and adverse effects of middle-dose (25 Gy) vs. low-dose (10-12 Gy) total skin electron beam therapy were retrospectively compared in a series of 14 and 12 mycosis fungoides, respectively. Read More

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http://dx.doi.org/10.2340/00015555-3124DOI Listing
January 2019
2 Reads

Severe and Lethal Presentation of Folliculotropic Mycosis Fungoides.

Actas Dermosifiliogr 2019 Jan 11. Epub 2019 Jan 11.

Instituto Nacional de Cancerología, Bogotá, Colombia.

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http://dx.doi.org/10.1016/j.ad.2018.02.027DOI Listing
January 2019
2 Reads

[Clinicopathological characteristics of adult T cell leukemia/lymphoma].

Zhonghua Bing Li Xue Za Zhi 2019 Jan;48(1):11-16

Department of Pathology, Fujian Cancer Hospital, Fujian Medical University Cancer Hospital, Fuzhou 350014, China.

To investigate the clinical presentation, clinicopathologic features, diagnosis and differential diagnosis of adult T cell leukemia/lymphoma (ATLL). Four cases of ATLL from Fujian Cancer Hospital between October 2017 and May 2018 were analyzed using hematoxylin-eosin and immunohistochemical stains and polymerase chain reaction (PCR) for HTLV-1 provirus genes. The relevant literature was reviewed. Read More

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http://dx.doi.org/10.3760/cma.j.issn.0529-5807.2019.01.003DOI Listing
January 2019
2 Reads

Immunotherapy in mycosis fungoides: opening night or dress rehearsal?

Leuk Lymphoma 2019 Jan 11:1-3. Epub 2019 Jan 11.

a Department of Medicine , Lymphoma Service, Memorial Sloan Kettering Cancer Center , New York , NY , USA.

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https://www.tandfonline.com/doi/full/10.1080/10428194.2018.1
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http://dx.doi.org/10.1080/10428194.2018.1562186DOI Listing
January 2019
7 Reads

Benign T cells drive clinical skin inflammation in cutaneous T cell lymphoma.

JCI Insight 2019 Jan 10;4(1). Epub 2019 Jan 10.

Department of Dermatology, Brigham and Women's Hospital, Harvard Medical School, Boston, Massachusetts, USA.

Psoralen plus UVA (PUVA) is an effective therapy for mycosis fungoides (MF), the skin-limited variant of cutaneous T cell lymphoma (CTCL). In low-burden patients, PUVA reduced or eradicated malignant T cells and induced clonal expansion of CD8+ T cells associated with malignant T cell depletion. High-burden patients appeared to clinically improve but large numbers of malignant T cells persisted in skin. Read More

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http://dx.doi.org/10.1172/jci.insight.124233DOI Listing
January 2019
6 Reads

Measurement of Quality of Life in Patients with Mycosis Fungoides/Sézary Syndrome Cutaneous T-Cell Lymphoma: Development of an Electronic Instrument.

J Med Internet Res 2019 Jan 7;21(1):e11302. Epub 2019 Jan 7.

PatientsLikeMe, Inc, Cambridge, MA, United States.

Background: Although the quality of life (QoL) plays an important role in treatment decision making and clinical management of mycosis fungoides (MF) or Sézary syndrome (SS) subtypes of cutaneous T-cell lymphomas (MF/SS-CTCLs), an MF- or SS-specific measure of QoL does not exist.

Objective: The objective of this research was to develop and validate the first QoL instrument for MF/SS-CTCL using a patient-centered approach.

Methods: A conceptual framework for the MF/SS-CTCL QoL was developed through a literature review and interviews with key opinion leaders. Read More

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https://www.jmir.org/2019/1/e11302/
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http://dx.doi.org/10.2196/11302DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6329422PMC
January 2019
14 Reads

Understanding racial disparities in mycosis fungoides through international collaborative studies.

Br J Dermatol 2019 Jan 3. Epub 2019 Jan 3.

Dermatology Service, Department of Medicine, Memorial Sloan Kettering Cancer Center and Weill Cornell Medicine, New York, NY, U.S.A.

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http://doi.wiley.com/10.1111/bjd.17598
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http://dx.doi.org/10.1111/bjd.17598DOI Listing
January 2019
3 Reads

Ethnicity in mycosis fungoides: white patients present at an older age and with more advanced disease.

Br J Dermatol 2019 Jan 3. Epub 2019 Jan 3.

Leiden University Medical Centre, Leiden, the Netherlands.

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http://dx.doi.org/10.1111/bjd.17602DOI Listing
January 2019
2 Reads

Mycosis fungoides after treatment with tumor necrosis factor-alpha inhibitors for psoriasis: progression or onset?

Int J Dermatol 2019 Jan 3. Epub 2019 Jan 3.

Department of Dermatology, Consorcio Hospital General Universitario de Valencia, Valencia, Spain.

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http://doi.wiley.com/10.1111/ijd.14367
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http://dx.doi.org/10.1111/ijd.14367DOI Listing
January 2019
2 Reads
1.227 Impact Factor

Adult-Onset Atopic Dermatitis.

J Allergy Clin Immunol Pract 2019 Jan;7(1):28-33

Departments of Dermatology, Preventive Medicine and Medical Social Sciences, Feinberg School of Medicine at Northwestern University, Chicago, Ill; Northwestern Medicine Multidisciplinary Eczema Center, Chicago, Ill. Electronic address:

One in 4 adults with atopic dermatitis (AD) report adult-onset disease. Adult-onset AD appears to be associated with a different disease phenotype compared with childhood-onset AD. A broad differential diagnosis must be considered in a patient presenting with an adult-onset eczematous eruption, including allergic contact dermatitis, mycosis fungoides/cutaneous T-cell lymphoma, psoriasis, scabies, and so forth. Read More

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http://dx.doi.org/10.1016/j.jaip.2018.09.029DOI Listing
January 2019
2 Reads

Utility of CD123 immunohistochemistry in differentiating lupus erythematosus from cutaneous T-cell lymphoma.

Histopathology 2018 Dec 31. Epub 2018 Dec 31.

Department of Pathology, University of Michigan, Ann Arbor, MI.

Aims: Histopathologic overlap between lupus erythematosus and certain types of cutaneous T-cell lymphoma (CTCL) is well documented. CD123+ plasmacytoid dendritic cells (PDCs) are typically increased in lupus erythematosus, but have not been well studied in CTCL. We aimed to compare CD123 immunostaining and histopathologic features in these conditions. Read More

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http://dx.doi.org/10.1111/his.13817DOI Listing
December 2018
1 Read

CD30-Positive Lymphoproliferative Disorders.

Cancer Treat Res 2019 ;176:249-268

Division of Dermatology, City of Hope National Medical Center, Duarte, CA, USA.

Primary cutaneous CD30-positive lymphoproliferative disorders (CD30+ LPD) encompass lymphomatoid papulosis (LyP), primary cutaneous anaplastic large cell lymphoma (pcALCL), and borderline lesions [1]. CD30+ LPD are the second most common cutaneous T-cell lymphomas (CTCL) after mycosis fungoides (MF) and represent approximately 25% of all CTCL cases [2]. Their common phenotypic hallmark is an expression of the CD30 antigen, a cytokine receptor belonging to the tumor necrosis factor (TNF) receptor superfamily. Read More

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http://dx.doi.org/10.1007/978-3-319-99716-2_12DOI Listing
January 2019
1 Read

Primary Cutaneous T-Cell Lymphomas: Mycosis Fungoides and Sezary Syndrome.

Cancer Treat Res 2019 ;176:225-248

Department of Hematology/Hematopoietic Cell Transplantation, Duarte, USA.

Mycosis fungoides and Sézary syndrome are the most common subtypes of all primary cutaneous lymphomas and represent complex diseases that require a multidisciplinary assessment by dermatologists, oncologists, and pathologists. Staging and work-up are critical to guarantee an optimal treatment plan that includes skin-directed and/or systemic regimens depending on the clinical stage, tumor burden, drug-related side effect profile, and patient comorbidities. However, there is no cure and patients frequently relapse, requiring repeated treatment courses for disease control. Read More

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http://dx.doi.org/10.1007/978-3-319-99716-2_11DOI Listing
January 2019
11 Reads

Molecular and Genomic Landscape of Peripheral T-Cell Lymphoma.

Cancer Treat Res 2019 ;176:31-68

Department of Pathology, City of Hope National Medical Center, Duarte, CA, USA.

Peripheral T-cell lymphoma (PTCL) is an uncommon group of lymphoma covering a diverse spectrum of entities. Little was known regarding the molecular and genomic landscapes of these diseases until recently but the knowledge is still quite spotty with many rarer types of PTCL remain largely unexplored. In this chapter, the recent findings from gene expression profiling (GEP) studies, including profiling data on microRNA, where available, will be presented with emphasis on the implication on molecular diagnosis, prognostication, and the identification of new entities (PTCL-GATA3 and PTCL-TBX21) in the PTCL-NOS group. Read More

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http://dx.doi.org/10.1007/978-3-319-99716-2_2DOI Listing
January 2019
1 Read

Alemtuzumab is an effective third-line treatment versus single-agent gemcitabine or pralatrexate for refractory Sézary syndrome: a systematic review.

Eur J Dermatol 2018 Dec;28(6):764-774

Department of Dermatology, UT Southwestern Medical Center, Dallas, TX, USA.

The efficacy of alemtuzumab for the treatment of refractory Sézary syndrome (SS) versus other third-line agents such as pralatrexate and gemcitabine is poorly characterized. To elucidate the effectiveness of alemtuzumab versus other third-line options for the treatment of refractory SS, we conducted a meta-analysis of existing data. A systematic review was performed in March 2017 based on a search using Ovid-MEDLINE and OVID-EMBASE for articles evaluating single-agent alemtuzumab, gemcitabine, or pralatrexate for the treatment of SS and mycosis fungoides (MF). Read More

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http://dx.doi.org/10.1684/ejd.2018.3444DOI Listing
December 2018
3 Reads

A Nodular Lesion of the Foot Detected by 18F-FDG PET/CT in Mycosis Fungoides: A Plantar Wart.

Clin Nucl Med 2019 Mar;44(3):244-245

From the Departments of Dermatology and.

A 34-year-old Japanese woman presented with widespread scaly erythema that had enlarged over 2 years. A skin biopsy revealed the diagnosis of mycosis fungoides (patch stage, T1b N0 M0 B0), a most frequent cutaneous T-cell lymphoma. F-FDG PET/CT scan unexpectedly showed intense uptake on the left sole, which suggested a tumorous mycosis fungoides lesion (SUVmax = 6. Read More

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http://dx.doi.org/10.1097/RLU.0000000000002430DOI Listing
March 2019
8 Reads

Lymphoma or pseudolymphoma: A report of six cases and review of the literature.

Dermatol Ther 2018 Dec 27:e12807. Epub 2018 Dec 27.

Department of Dermatology, Peking Union Medical College Hospital, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing, China.

To explore and compare the clinical presentations and pathologic features of cutaneous pseudolymphomas (CPL) with primary cutaneous lymphomas. Review literature in order to improve the treatment of CPL. Six cases of CPLs were collected. Read More

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http://dx.doi.org/10.1111/dth.12807DOI Listing
December 2018
8 Reads
1.478 Impact Factor

Clinical application of Total Skin Electron Beam (TSEB) therapy for the management of T cell cutaneous lymphomas. The evolving role of low dose (12 Gy) treatment schedule.

Clin Transl Radiat Oncol 2019 Feb 6;15:26-30. Epub 2018 Dec 6.

National Kapodistrian University of Athens, Medical School, 2nd Dpt Radiology, Radiotherapy Unit, ATTIKON University Hospital, Athens, Greece.

Background & Purpose: Although rare, cutaneous lymphomas represent a separate entity in hematologic oncology. T cell origin lymphomas are most common, with Mycosis Fungoides (MF) accounting for about 50-70% of cases. Sezary Syndrome (SS), which represents the leukemic varian of MF, accounts for 3% of Cutaneous T Cell Lymphomas (CTCL). Read More

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http://dx.doi.org/10.1016/j.ctro.2018.12.002DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6293019PMC
February 2019
7 Reads

Pagetoid reticulosis (Woringer-Kolopp disease) in a 2-year-old girl-Case report and review of the literature.

JAAD Case Rep 2019 Jan 15;5(1):104-107. Epub 2018 Dec 15.

Section of Dermatology, Department of Medical Science and Public Health, University of Cagliari, Cagliari, Italy.

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https://linkinghub.elsevier.com/retrieve/pii/S23525126183032
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http://dx.doi.org/10.1016/j.jdcr.2018.10.023DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6297267PMC
January 2019
2 Reads

Mycosis Fungoides Involving the Dorsal Tongue.

Case Rep Dermatol Med 2018 19;2018:5235246. Epub 2018 Nov 19.

Department of Dermatology, University of Texas McGovern Medical School at Houston, Houston, TX, USA.

Mycosis fungoides (MF) is a rare cutaneous T-cell lymphoma (CTCL) which can cause significant morbidity. During the disease course, it classically will progress through three clinical stages in the skin: patch-, plaque-, and tumor-stage. The early stages exhibit various histopathological mimics that often lead to misdiagnosis. Read More

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http://dx.doi.org/10.1155/2018/5235246DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6276500PMC
November 2018
5 Reads

Post-thymic CD4 positive cytotoxic T cell infiltrates of the skin: A clinical and histomorphologic spectrum of the unique CD4 positive T cell of immunosenescence.

Ann Diagn Pathol 2019 Feb 27;38:99-105. Epub 2018 Oct 27.

Department of Pathology, Dartmouth-Hitchcock Medical Center, Lebanon, NH, USA.

T cell lymphoproliferative disorders that arise in the skin are mainly derived from post thymic T cells most commonly of CD4 subset. Human CD4 positive T cells are dynamic exhibiting phenotypic and functional malleability. For example, with repetitive antigen exposure most commonly associated with age, CD4 positive T cells acquire a cytotoxic phenotype. Read More

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https://linkinghub.elsevier.com/retrieve/pii/S10929134183031
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http://dx.doi.org/10.1016/j.anndiagpath.2018.10.010DOI Listing
February 2019
7 Reads

Interferon alfa-2a maintenance after salvage autologous stem cell transplantation in atypical mycosis fungoides with central nervous system involvement.

Br J Dermatol 2018 Dec 18. Epub 2018 Dec 18.

Department of Dermatology, University of Zurich, University Hospital Zurich, Zurich, Switzerland.

Mycosis fungoides is a primary cutaneous T-cell lymphoma with unfavorable prognosis for the advanced stages of the disease. Refractory disease and advanced-stage disease require systemic therapy. We report on a rare case of an atypical predominantly CD8+ folliculotropic mycosis fungoides (MF), a subtype of MF with poorer prognosis, in a 59-year-old woman, initially diagnosed with MF restricted to the skin- of T3N0M0B0/stage IIB according to the current WHO/EORTC classification. Read More

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http://doi.wiley.com/10.1111/bjd.17535
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http://dx.doi.org/10.1111/bjd.17535DOI Listing
December 2018
10 Reads

Merkel cell carcinoma arising in association with cutaneous T-cell lymphoma: A potential diagnostic pitfall.

J Cutan Pathol 2019 Mar 4;46(3):199-203. Epub 2019 Jan 4.

Department of Pathology, Michigan Medicine, Ann Arbor, Michigan.

Merkel cell carcinoma (MCC) is a rare, aggressive cutaneous neuroendocrine carcinoma with increased prevalence in patients with immunosuppression or B-cell neoplasms. To the best of our knowledge, an association with cutaneous T-cell lymphoma (CTCL) has not been previously described. In this report, we present two cases of MCC arising in the setting of CTCL. Read More

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http://dx.doi.org/10.1111/cup.13404DOI Listing
March 2019
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New therapies and old side-effects in mycosis fungoides treatment: brentuximab vedotin-induced alopecia.

Br J Dermatol 2018 Dec 18. Epub 2018 Dec 18.

Dermatology Unit, Department of Experimental, Diagnostic and Speciality Medicine, University of Bologna, Via Massarenti 1, Bologna, Italy.

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http://dx.doi.org/10.1111/bjd.17533DOI Listing
December 2018
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Mycosis fungoides, Psoriasis and Anti-PD-1 - A New Aspect of Known Associations.

J Dtsch Dermatol Ges 2019 Feb 14;17(2):186-188. Epub 2018 Dec 14.

Dermatology Service, Department of Medicine, Memorial Sloan Kettering Cancer Center, and Weill Cornell Medicine, New York, NY, USA.

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https://onlinelibrary.wiley.com/doi/abs/10.1111/ddg.13715
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http://dx.doi.org/10.1111/ddg.13715DOI Listing
February 2019
7 Reads