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    The Use of Central Pathology Review With Digital Slide Scanning in Advanced-stage Mycosis Fungoides and Sézary Syndrome: A Multi-institutional and International Pathology Study.
    Am J Surg Pathol 2018 Mar 14. Epub 2018 Mar 14.
    Dermatology, Stanford University, Palo Alto.
    This pathology PILOT study aims to define the role and feasibility of centralized pathology review in a cohort of 75 patients from different centers in the United States and Europe using digital slide scanning. The pathologic material from 75 patients who had been diagnosed with mycosis fungoides/Sézary syndrome and were clinically staged as IIb or above was retrieved from 11 participating centers. Each pathology reviewer was provided with the pathologic diagnosis (by the referring pathologist), and the following list of histopathologic criteria (presence or absence) from the initial report: epidermotropism, folliculotropism (FT), large cell transformation, syringotropism, and granulomas. Read More

    Phototherapy as a first line treatment for early stage mycosis fungoides: The results of a large retrospective analysis.
    Photodermatol Photoimmunol Photomed 2018 Mar 13. Epub 2018 Mar 13.
    Cutaneous lymphoma clinic, A.Sygros Hospital for skin diseases, National& Kapodestrian University of Athens Medical School, Athens, Greece.
    Background: Phototherapy is one of the main treatments for mycosis fungoides (MF). In this study, we analyzed the efficacy and safety of phototherapy as a first line treatment in patients with early stage disease.

    Methods: We analyzed treatment outcomes in a group of 227 early stage patients. Read More

    Successful Treatment of Erythrodermic Mycosis Fungoides with Mogamulizumab Followed by Etoposide Monotherapy.
    Case Rep Oncol 2018 Jan-Apr;11(1):29-32. Epub 2018 Jan 16.
    Department of Dermatology, Tohoku University Graduate School of Medicine, Sendai, Japan.
    Mogamulizumab induces cytotoxicity against CCR4+ lymphoma cells by antibody-dependent cell-mediated cytotoxicity in advanced cutaneous T-cell lymphoma patients. Since the efficacy of mogamulizumab in mycosis fungoides (28.6%) is lower than that in Sézary syndrome (47. Read More

    Large-Cell Transformed Mycosis Fungoides Coexisting with Mycosis Fungoides Bullosa: A Case Report and Review of the Literature.
    Case Rep Dermatol 2017 Sep-Dec;9(3):243-248. Epub 2017 Nov 27.
    Division of Dermatology, Department of Medicine, Faculty of Medicine, Ramathibodi Hospital, Mahidol University, Bangkok, Thailand.
    Mycosis fungoides is the most common form of cutaneous T-cell lymphoma. Both large-cell transformed mycosis fungoides and mycosis fungoides bullosa are rare presentations and predict unfavorable prognosis. We report the case of a 61-year-old woman who presented with generalized erythematous scaly annular plaques, and histopathology confirmed the diagnosis of mycosis fungoides. Read More

    Tumor-stage mycosis fungoides in palmoplantar localization with large cell transformation and partial CD30 expression shows complete response to brentuximab vedotin.
    J Cutan Pathol 2018 Mar 7. Epub 2018 Mar 7.
    Department of Pathology and Laboratory Medicine, Dartmouth-Hitchcock Medical Center, Geisel School of Medicine, Lebanon, NH.
    Mycosis fungoides in palmoplantar localization (MFPP) is a rare variant of MF that is confined to the hands and feet. Patients commonly receive treatment over many years for suspected palmoplantar dermatitis before the diagnosis is made. Most MFPP patients remain at patch or plaque stage, and often respond to treatment with radiotherapy. Read More

    Novel phosphorylated TAK1 species with functional impact on NF-κB and β-catenin signaling in human Cutaneous T-cell lymphoma.
    Leukemia 2018 Feb 22. Epub 2018 Feb 22.
    Stem Cells and Cancer Research Laboratory, CIBERONC, Institut Hospital del Mar Investigacions Mèdiques (IMIM), 08003, Barcelona, Spain.
    Cutaneous T-cell lymphomas (CTCLs) represent different subtypes of lymphoproliferative disorders with no curative therapies for the advanced forms of the disease (namely mycosis fungoides and the leukemic variant, Sézary syndrome). Molecular events leading to CTCL progression are heterogeneous, however recent DNA and RNA sequencing studies highlighted the importance of NF-κB and β-catenin pathways. We here show that the kinase TAK1, known as essential in B-cell lymphoma, is constitutively activated in CTCL cells, but tempered by the MYPT1/PP1 phosphatase complex. Read More

    Hyperpigmentation and higher incidence of cutaneous malignancies in moderate-high PCB- and dioxin exposed individuals.
    Environ Res 2018 Mar 1;164:221-228. Epub 2018 Mar 1.
    Department of Dermatology and Allergology, RWTH Aachen University, Pauwelstrasse 30, 52074 Aachen, Germany.
    Polychlorinated biphenyls (PCB) are well known persistent and toxic environmental pollutants. Our aim was to identify effects of moderate-high exposure to dioxin-like (dl) and non-dioxin-like (ndl)-PCBs on the skin in order to provide more insight in the pathophysiological effects of these compounds. We performed a dermatological examination on 92 former workers from a transformer recycling company with known elevated serum PCB and/or dioxin (polychlorinated dibenzo-p-dioxin/polychlorinated dibenzo-p-furan (PCDD/F)) levels. Read More

    Results of radiotherapy in minimal stage mycosis fungoides: a reappraisal after ten years.
    G Ital Dermatol Venereol 2018 Feb 26. Epub 2018 Feb 26.
    Dipartimento di Fisiopatologia Medico-Chirurgica e dei Trapianti, Università degli Studi di Milano, Milan, Italy.
    Background: Mycosis Fungoides (MF) is the most common cutaneous T cell lymphoma, accounting for 54-72 % of cases. When it presents as solitary or oligolesional picture, radiotherapy is considered potentially curative. To verify this we decided to evaluate the outcome in 15 patients studied in the period 1990-2007 after ten years. Read More

    Blood classification and blood response criteria in mycosis fungoides and Sézary syndrome using flow cytometry: recommendations from the EORTC cutaneous lymphoma task force.
    Eur J Cancer 2018 Feb 21;93:47-56. Epub 2018 Feb 21.
    Leiden University Medical Centre, The Netherlands.
    Our current mycosis fungoides (MF) and Sézary Syndrome (SS) staging system includes blood-classification from B0-B2 for patch/plaque/tumour or erythroderma based on manual Sézary counts but results from our EORTC survey confirm these are rarely performed in patch/plaque/tumour MF, and there is a trend towards using flow cytometry to measure blood-class. Accurately assigning blood-class effects overall stage and the 'global response' used to measure treatment responses in MF/SS and hence impacts management. The EORTC Cutaneous Lymphoma Task Force Committee have reviewed the literature and held a Workshop (June 2017) to agree a definition of blood-class according to flow cytometry. Read More

    Index Case of Cutaneous Follicular Mycosis Fungoides With Central Nervous System Involvement and Review of Literature.
    Am J Dermatopathol 2018 Mar;40(3):185-190
    Department of Neurology, University of Colorado Anschutz Medical College, Aurora, CO.
    Central nervous system involvement by mycosis fungoides (MF) is rare and is usually seen in advanced stages of the disease. We describe a patient with early-stage follicular MF who presented with changes in mental status. Despite an initial diagnosis of vasculitis based on clinical and brain biopsy results, the postmortem examination revealed extensive infiltration of MF cells throughout the brain with leptomeningeal involvement. Read More

    Eosinophilic infiltrate resembling eosinophilic cellulitis (Wells syndrome) in a patient with mycosis fungoides.
    Dermatol Online J 2018 Jan 15;24(1). Epub 2018 Jan 15.
    Department of Internal Medicine, Baylor College of Medicine, Houston, Texas.
    Mycosis fungoides (MF) is a T-cell, non-Hodgkin lymphoma that primarily involves the skin. Extracutaneous involvement, such as in the parotidgland, is characteristic of end-stage disease. Eosinophilic cellulitis, or Wells syndrome, is a rare inflammatory dermatitis that involves a dermal infiltrate of eosinophils. Read More

    Folliculin mutation-negative trichodiscomas in a patient with multiple endocine neoplasia type I syndrome.
    Dermatol Online J 2017 Aug 15;23(8). Epub 2017 Aug 15.
    Harvard Medical School, Boston, Massachusetts.
    Mycosis fungoides (MF) is the most common cutaneous T cell lymphoma that involves the oral mucosal. The manifestation of lesions within the oral cavity generally correlates with a poor prognosis. Management of MF includes skin directed therapies and localized radiation treatment, with systemic biologic therapies and chemotherapy used for more advanced stages. Read More

    Psoriasiform mycosis fungoides: a rare form of the disease with review of the literature.
    Dermatol Online J 2017 Sep 15;23(9). Epub 2017 Sep 15.
    Department of Dermatology, Razi Hospital, Tehran University of Medical Sciences, Tehran, Iran.
    Background: Mycosis fungoides (MF) typically presents as erythematous scaly patches or plaques that may progress to cutaneous tumors. Although MF may be presented like other dermatoses, initial presentation as psoriasiform plaques simulating psoriasis is rare. Differentiating MF from psoriasis is important because systemic therapies used for psoriasis can worsen MF. Read More

    Nail Changes in Early Mycosis Fungoides.
    Skin Appendage Disord 2018 Jan 10;4(1):55-59. Epub 2017 Aug 10.
    Tehran University of Medical Sciences, Tehran, Iran.
    Background: Mycosis fungoides (MF) has a wide range of clinical presentations and it has been reported rarely to involve the nail apparatus.

    Objective: We intended to evaluate the frequency and characteristics of nail changes in patients with biopsy-proven MF.

    Methods: A retrospective analysis of 60 patients with MF who were evaluated at our cancer center from 2013 to 2014 was performed to identify patients with nail changes. Read More

    Adult T-cell leukemia/lymphoma can be indistinguishable from other more common T-cell lymphomas. The University of Miami experience with a large cohort of cases.
    Mod Pathol 2018 Feb 15. Epub 2018 Feb 15.
    Department of Pathology, Division of Hematopathology, University of Miami, Sylvester Comprehensive Cancer Center, and Jackson Memorial Hospitals, Miami, FL, USA.
    Adult T-cell leukemia/lymphoma, an aggressive T-cell neoplasm, is causally linked to human T-cell lymphotropic virus type 1 and based on this association has a distinct geographic distribution. In our United States-based practice, whose population is enriched for immigrants from human T-cell lymphotropic virus type 1 endemic areas, we have identified that a subset of adult T-cell leukemia/lymphoma, in the absence of human T-cell lymphotropic virus type 1 identification, are indistinguishable from other more common T-cell neoplasms. We retrospectively gathered serology results for anti-human T-cell lymphotropic virus type 1/2 antibody in patients diagnosed with T-cell neoplasms at our institution. Read More

    Case report: photo-onycholysis after PUVA treatment for hypopigmented mycosis fungoides with response to topical steroid.
    Clin Case Rep 2018 Feb 22;6(2):267-268. Epub 2017 Dec 22.
    Department of DermatologyAddenbrookes HospitalCambridgeUK.
    Melanin in the nail bed in patients with skin type VI has been suggested to afford some protection against photo-onycholysis. We report a case of a 16-year-old male patient with skin type VI with onycholysis following PUVA treatment for hypopigmented mycosis fungoides. Symptoms resolved with the application of topical steroid. Read More

    Clinical potential of mechlorethamine gel for the topical treatment of mycosis fungoides-type cutaneous T-cell lymphoma: a review on current efficacy and safety data.
    Drug Des Devel Ther 2018 31;12:241-254. Epub 2018 Jan 31.
    Department of Hematology/Oncology, Levine Cancer Institute, Carolinas Medical Center, Charlotte, NC, USA.
    Nitrogen mustard is a chemotherapeutic agent that has a well-documented safety and efficacy profile in the treatment of cutaneous T-cell lymphoma. Development of nitrogen mustard formulations and treatment regimens has been studied extensively over the last 40 years. In the last 5 years, a new gel formulation has been developed that is associated with a decrease in delayed hypersensitivity reactions. Read More

    Successful treatment of extensive splanchnic vein thrombosis in a patient with mycosis fungoides.
    BMJ Case Rep 2018 Feb 5;2018. Epub 2018 Feb 5.
    Department of Interventional Radiology, Jaslok Hospital and Research Centre, Mumbai, Maharashtra, India.
    A 33-year-old man of a Middle Eastern origin presented to us with abdominal pain and distension secondary to refractory ascites of 1-month duration. The patient had a history of taking oral retinoic acid 25 mg for 4 months for mycosis fungoides. Investigations revealed thrombosis of hepatic veins with extensive thrombosis of the porto-mesenteric axis. Read More

    Current applications of high-frequency ultrasonography in dermatology.
    Postepy Dermatol Alergol 2017 Dec 31;34(6):535-542. Epub 2017 Dec 31.
    Department of Dermatology, Poznan University of Medical Sciences, Poznan, Poland.
    The era of ultrasounds in dermatology started in 1979, when pioneering use of 15 MHz by Alexander and Miller in measuring the skin thickness was introduced. Since then, some new applications of high-frequency ultrasonography (HF-USG) have emerged providing the clinicians with an extra hand in their everyday practice. The main advantages of HF-USG include the possibility of real-time imaging, measurements of morphological and physiological aspects of the skin, safety associated with the use of non-ionizing media as well as the lack of contraindications to its performance. Read More

    High-frequency ultrasonography-New non-invasive method in assessment of skin lymphomas.
    Skin Res Technol 2018 Jan 31. Epub 2018 Jan 31.
    Department of Dermatology, University of Medical Sciences, Poznań, Poland.
    Background: Mycosis fingoides (MF) is the most common subtype of primary cutaneous T-cell lymphomas. Current evaluation of disease extent and severity is based on mSWAT scoring system, which seems to be relatively subjective. The aim of this subject was to present the usefulness of 20 MHz in objective 5-year long monitoring of response to therapy in MF patients. Read More

    The pathological spectrum and clinical correlation of pigmented purpuric dermatosis-A retrospective review of 107 cases.
    J Cutan Pathol 2018 Jan 30. Epub 2018 Jan 30.
    Department of Dermatology, Mackay Memorial Hospital, Taipei, Taiwan.
    Background: Various pathological findings have been reported in pigmented purpuric dermatosis, but their clinical significance remains unclear.

    Methods: We retrospectively reviewed demographics, clinical presentations, pathological patterns and concurrent systemic diseases among biopsy-confirmed cases of pigmented purpuric dermatosis.

    Results: A total of 107 cases were ascertained. Read More

    Clinical and histological evaluation in patients with mycosis fungoides treated with UVA1.
    G Ital Dermatol Venereol 2018 Jan 24. Epub 2018 Jan 24.
    Department of Dermatology, Division of Medical, Surgical and Neurosciences, University of Siena, Siena, Italy.
    Background: UVA1 phototherapy is a valid therapeutic alternative for skin lymphoproliferative disorders, although there are few studies concerning its role in mycosis fungoides (MF). Our aim was to evaluate and confirm the effectiveness of UVA1 phototherapy in patients in early stage Mycosis Fungoides (MF).

    Methods: We enrolled 12 patients, 9 males and 3 females (mean age 54. Read More

    Drug induced pseudolymphoma.
    Semin Diagn Pathol 2018 Jan 17. Epub 2018 Jan 17.
    Regional Medical Laboratory, 4142 South Mingo Road, Tulsa, OK 74146-3632, United States.
    Atypical lymphocytic infiltrates of the skin comprise a broad spectrum of entities ranging from benign infiltrates to those that are malignant. Many of these infiltrates are in fact reactive lymphomatoid ones related to drug therapy falling under the general category of drug associated pseudolymphoma. Within this nosologic umbrella are nodular and diffuse infiltrates resembling low grade T and B cell lymphoma consistent with lymphocytoma cutis, drug associated reversible T cell dyscrasias which draw a strong morphologic and phenotypic parallel with mycosis fungoides and the various pre-lymphomatous T cell dyscrasias, and angiocentric CD30 positive infiltrates mirroring lymphomatoid papulosis. Read More

    T-cell papulosis associated with B-cell malignancy: a distinctive clinicopathologic entity.
    J Eur Acad Dermatol Venereol 2018 Jan 22. Epub 2018 Jan 22.
    Service de Dermatologie, Hôpital Robert Debré, Reims, France.
    Background: A distinctive eruption referred to as 'insect bite-like reaction' or 'eosinophilic dermatosis of haematological malignancy' has been described during the course of haematological B-cell malignancies (BCM). However, its clinical evolution, histopathological features and pathogenesis remain unclear.

    Objectives: To characterize this eruption and to investigate its pathogenesis and relationship with the underlying BCM. Read More

    Dose optimization of total or partial skin electron irradiation by thermoluminescent dosimetry.
    Strahlenther Onkol 2018 Jan 19. Epub 2018 Jan 19.
    Department of Radiation Oncology, University Hospital, LMU Munich, Marchioninistraße 15, 81377, Munich, Germany.
    Background: Due to the complex surface of the human body, total or partial skin irradiation using large electron fields is challenging. The aim of the present study was to quantify the magnitude of dose optimization required after the application of standard fields.

    Methods: Total skin electron irradiation (TSEI) was applied using the Stanford technique with six dual-fields. Read More

    Mogamulizumab-induced photosensitivity in patients with mycosis fungoides and other T-cell neoplasms.
    J Eur Acad Dermatol Venereol 2018 Jan 16. Epub 2018 Jan 16.
    Department of Dermatology, Hamamatsu University School of Medicine, Hamamatsu, Japan.
    Background: Mogamulizumab (Mog) is a defucosylated, therapeutic monoclonal antibody, targeting CCR4 and was first approved in Japan for the treatment of adult T-cell leukaemia/lymphoma (ATLL), followed by cutaneous T-cell lymphoma and peripheral T-cell lymphoma.

    Objective: To retrospectively investigate development of photosensitivity in patients with mycosis fungoides and other T-cell neoplasms after treatment with Mog.

    Methods: We treated seven cutaneous lymphoma patients with Mog. Read More

    Sézary syndrome managed with histone deacetylase inhibitor followed by anti-CCR4 monoclonal antibody.
    Clin Exp Dermatol 2018 Apr 12;43(3):281-285. Epub 2018 Jan 12.
    Department of Dermatology, Tokyo Medical University, Tokyo, Japan.
    A 70-year-old man presented to our clinic with a 10-year history of recurrent pruritic erythema and plaques on his trunk and limbs. Based on the pathological findings and monoclonal rearrangement of the T-cell receptor (TCR)-Cβ1 gene, mycosis fungoides (T2N0M0B0 stage IB) was diagnosed. Despite combination therapy including histone deacetylase inhibitor (vorinostat), the symptoms slowly evolved into Sézary syndrome (SS; T4N1M0B2) over 4 years, with dense infiltrates due to atypical lymphocytes expressing CCR4 developing in the entire dermis. Read More

    Synchronous Occurrence of Mycosis Fungoides, Diffuse Large B cell Lymphoma and Acute Myeloid Leukemia: A Report of Two Cases.
    Intern Med 2018 Jan 11. Epub 2018 Jan 11.
    Department of Hematology and Rheumatology, Kindai University Faculty of Medicine, Japan.
    Patients with mycosis fungoides (MF), the most common subtype of primary cutaneous T-cell lymphoma, have an increased risk of developing secondary malignancies. We herein report two rare cases of MF concurring with diffuse large B cell lymphoma (B lymphoid lineage) and acute myeloid leukemia (myeloid lineage) in two otherwise healthy elderly patients. Potential etiologic factors, including the impact of the therapy-associated inflammatory response on the development of secondary tumors in patients with MF, are discussed. Read More

    How to Discern Folliculotropic Mycosis Fungoides From Follicular Mucinosis Using a Pediatric Case.
    J Cutan Med Surg 2018 Jan 1:1203475417752366. Epub 2018 Jan 1.
    3 Department of Dermatology, University of Texas MD Anderson Cancer Center, Houston, TX, USA.
    Folliculotropic mycosis fungoides (FMF) is a variant of mycosis fungoides (MF) with folliculotropic, atypical lymphocytes that may or may not have mucin deposition surrounding the hair follicle. Follicular mucinosis (FM) is a primary or secondary finding in FMF, lupus, or collagen vascular diseases that is only a histological process of mucin deposition surrounding the hair follicles. We present a case of a 6-year-old boy who had features of both FMF and primary follicular mucinosis (PFM). Read More

    Hypopigmented mycosis fungoides: a 20-case retrospective series.
    Int J Dermatol 2018 Mar 10;57(3):306-312. Epub 2018 Jan 10.
    Sector of Dermatology, Post-Graduation Course in Dermatology and Post Graduation Program in Medical Clinics, University Hospital and School of Medicine, Federal University of Rio de Janeiro, Rio de Janeiro, Brazil.
    Background: Hypopigmented mycosis fungoides (hMF) is a rare subtype of mycosis fungoides. The aim of this study was to identify the clinical-epidemiological profile of our patient group and also to provide additional information about treatment responses and prognosis.

    Methods: This is a cross-sectional retrospective observational study, with exploratory analysis. Read More

    Dermoscopic characterization of cutaneous lymphomas: a pilot survey.
    Int J Dermatol 2018 Mar 10;57(3):339-343. Epub 2018 Jan 10.
    Department of Dermatology, University of Iowa Hospitals & Clinics, Iowa City, IA, USA.
    Background: While substantial dermoscopic analysis of melanocytic lesions has been performed, dermoscopic characterization of cutaneous lymphoid proliferations has been limited. Cutaneous lymphoma, particularly early mycosis fungoides (MF) and its variants, is often challenging to clinically and pathologically distinguish from inflammatory processes of the skin. This study aimed to survey the dermoscopic findings of cutaneous lymphomas and to discern whether any patterns might potentially serve as specific signatures. Read More

    Etoposide as a single agent in the treatment of mycosis fungoides: A retrospective analysis.
    Dermatol Ther 2018 Jan 9. Epub 2018 Jan 9.
    Department of Dermatology, Indiana University School of Medicine, Indianapolis, Indiana.
    Several chemotherapy agents have shown efficacy in the treatment of mycosis fungoides (MF). In the literature, there is limited data on the use of single agent etoposide for MF. We aimed to retrospectively review our experience with single agent etoposide in the treatment of advanced-stage or refractory early-stage MF with focus on analyzing its efficacy and safety. Read More

    Increased interleukin-36γ expression in skin and sera of patients with atopic dermatitis and mycosis fungoides/Sézary syndrome.
    J Dermatol 2018 Jan 3. Epub 2018 Jan 3.
    Department of Dermatology, University of Tokyo Graduate School of Medicine, Tokyo, Japan.
    Interleukin (IL)-36γ is expressed by keratinocytes and functions as a key initiator of inflammation in the skin. IL-36γ expression is enhanced by tumor necrosis factor-α and IL-17A, having a strong association with psoriasis. In this study, we examined the role of IL-36γ in atopic dermatitis (AD) and mycosis fungoides (MF)/Sézary syndrome (SS). Read More

    Current systemic therapeutic options for advanced mycosis fungoides and Sézary syndrome.
    Leuk Lymphoma 2018 Mar 8;59(3):562-577. Epub 2018 Jan 8.
    d Department of Medicine, Section of Dermatology , University of Chicago Medicine and Biological Sciences , Chicago , IL , USA.
    Mycosis fungoides (MF) and Sézary syndrome (SS) are the most common cutaneous T-cell lymphomas (CTCLs). Both lack curative options, and advanced-stage carries a poor prognosis. Whilst there are a number of treatments available, achieving and maintaining a durable remission remains challenging. Read More

    Progression of undiagnosed cutaneous lymphoma after anti-tumor necrosis factor alpha therapy.
    J Am Acad Dermatol 2018 Jan 4. Epub 2018 Jan 4.
    Department of Dermatology, Northwestern University, Feinberg School of Medicine, Northwestern Medicine, Chicago, IL. Electronic address:
    Background: Cutaneous lymphoma (CL) diagnosed after anti-tumor necrosis factor (TNF)α therapy has been reported in the literature, yet a clear link between both events remains elusive.

    Objective: To review our experience with CL diagnosed during or after the use of anti-TNFα therapies.

    Methods: This is a multicenter retrospective study and a literature review. Read More

    Mycosis fungoides occurring at the site of previous herpes zoster eruption.
    Australas J Dermatol 2017 Dec 26. Epub 2017 Dec 26.
    Department of Dermatology, University of Texas MD Anderson Cancer Center, Houston, Texas, USA.
    Numerous clinicopathological variants of mycosis fungoides have been described in the literature. Dermatomal or zosteriform mycosis fungoides is one reported variant but a clear aetiology has never been documented. We report a case of mycosis fungoides proved by biopsy and immunohistochemistry that developed in a 55-year-old man at the site of previous herpes zoster eruption. Read More

    Hyperpigmentation as a peculiar presentation of mycosis fungoides.
    An Bras Dermatol 2017 ;92(5 Suppl 1):92-94
    Department of Dermatology, Kaohsiung Veterans General Hospital - Kaohsiung, Taiwan.
    Hyperpigmented mycosis fungoides is an extremely rare subtype of mycosis fungoides. It presents as multiple pigmented macules and patches without poikilodermatous changes and characterized by a CD8+ phenotype on immunohistochemistry. This report describes a typical case of hyperpigmented mycosis fungoides in a 62-year-old woman, who presented with a 7-year history of multiple hyperpigmented macules and patches on the trunk and right leg with progression over this half a year. Read More

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