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Exp Dermatol 2020 Jun 3. Epub 2020 Jun 3.

Department of Dermatology, Aarhus University Hospital, Aarhus, Denmark.

Background: Several cancers, including mycosis fungoides (MF), have reported dysregulation of miR-195-5p. miR-195-5p plays a role in cell cycle regulation in several malignant diseases.

Objectives: This study aimed to investigate: i) the expression level of miR-195-5p in lesional MF skin biopsies and II) the potential regulatory roles of miR-195-5p in MF. Read More

JAAD Case Rep 2020 Jun 24;6(6):524-527. Epub 2020 Apr 24.

Department of Dermatology, Singapore General Hospital, Singapore.

JAAD Case Rep 2020 Jun 1;6(6):486-488. Epub 2020 May 1.

Dr. Phillip Frost Department of Dermatology and Cutaneous Surgery, University of Miami Miller School of Medicine, Miami, Florida.

Australas J Dermatol 2020 Jun 2. Epub 2020 Jun 2.

Department of Dermatology, Asan Medical Center, University of Ulsan College of Medicine, Seoul, Korea.

Extranodal natural killer/T-cell lymphoma (ENKTL) is a rare but aggressive cancer characterised by angiocentric and angiodestructive infiltration by NK-cells, or cytotoxic T-cell types. Histopathologically, ENKTL shows a multinodular or diffuse infiltration localised to vascular structures, resulting in angiodestruction and necrosis. We present a patient with an initially suspected diagnosis of benign interface dermatitis with a differential diagnosis of mycosis fungoides that was later found to be an aggressive extranodal natural killer/T-cell lymphoma of a nasal type and with a dismal prognosis. Read More

Hum Pathol 2020 May 29. Epub 2020 May 29.

Department of Hematopathology, The University of Texas MD Anderson Cancer Center, Houston, Texas.

T cell lymphomas are a heterogeneous group of neoplasms derived from mature T lymphocytes. These neoplasms are uncommon and usually diagnostically challenging. The focus of this paper is to suggest an immunohistochemistry-based, practical approach to assist in the diagnosis of nodal T-cell lymphomas. Read More

Br J Dermatol 2020 Jun 1. Epub 2020 Jun 1.

University Hospitals Birmingham, Birmingham, UK.

Background: The PROspective Cutaneous Lymphoma International Prognostic Index (PROCLIPI) Study is a prospective analysis of an international database and here we examine front-line treatments and quality-of-life in patients with newly diagnosed Mycosis Fungoides (MF).

Objectives: a) differences in first-line approach according to the TNMB staging; b) parameters related to a first-line systemic approach; c) response rates and quality of life (QoL) measures.

Patients And Methods: 395 newly diagnosed patients with early-stage MF (IA-IIA) were recruited from 41 centers in 17 countries between 1/1/2015-31/12/2018 following central clinicopathological review. Read More

Front Oncol 2020 12;10:765. Epub 2020 May 12.

Department of Dermatology, Johns Hopkins University, Baltimore, MD, United States.

Cutaneous T cell lymphomas (CTCL) comprise of a heterogeneous group of non-Hodgkin lymphomas derived from skin-homing T cells. Variation in clinical presentation and lack of definitive molecular markers make diagnosis especially challenging. The biology of CTCL remains elusive and clear links between genetic aberrations and epigenetic modifications that would result in clonal T cell expansion have not yet been identified. Read More

Kyobu Geka 2020 Jun;73(6):466-470

Department of Thoracic Surgery, Kanazawa Medical Center, Kanazawa, Japan.

A 65-year-old woman presented with mycosis fungoides and an anterior mediastinal tumor. Stage Ⅱa mycosis fungoides was treated with bath psoralen plus ultraviolet A, topical corticosteroids, and oral bexarotene. One month later, a surgical resection was performed for the anterior mediastinal tumor, which was a stage Ⅱ thymoma with membrane invasion. Read More

Dermatol Ther 2020 May 31:e13731. Epub 2020 May 31.

Department of Dermatology, Tohoku University Graduate School of Medicine, Sendai, Japan.

J Cutan Pathol 2020 May 27. Epub 2020 May 27.

Dermatopathology Bodensee, Friedrichshafen, Germany.

Lichen planus follicularis tumidus (LPFT) is a rare clinico-pathological variant of lichen planus (LP), clinically presenting with red-to-violaceous plaques studded with comedo-like lesions and keratin-filled milia-like cysts. Histopathologically, LPFT is characterized by cystically dilated follicular infundibula in the dermis, surrounded by a dense lichenoid lymphoid infiltrate with an associated interface reaction. We describe the clinico-pathological features of an additional case of LPFT, focusing on number and distribution of CD123(+) TCF4(+) plasmacytoid dendritic cells (pDCs). Read More

J Eur Acad Dermatol Venereol 2020 May 26. Epub 2020 May 26.

Center for Research & Development, Kaohsiung Municipal Siaogang Hospital, Kaohsiung, Taiwan.

Less is known about gastrointestinal (GI) involvement of primary skin diseases due to the difference in embryology, histology, microbiology and physiology between integument and alimentary tract. Esophagus, following the oropharyngeal mucosa, is the most common GI segment affected by primary skin diseases, especially by eosinophilic esophagitis, lichen planus, and autoimmune bullous dermatoses like pemphigus vulgaris, mucosal membrane pemphigoid and epidermolysis bullosa acquisita. Eosinophilic esophagitis is an emerging chronic atopic disease with esophageal dysfunction as the typical presentation, and esophageal narrowing, rings and stricture as late complications. Read More

J Invest Dermatol 2020 May 23. Epub 2020 May 23.

Department of Pathology, Zealand University Hospital, Denmark; Department of Clinical Medicine, University of Copenhagen, Denmark. Electronic address:

Acta Derm Venereol 2020 May 25. Epub 2020 May 25.

College of Physicians and Surgeons, Columbia University Vagelos, New York, USA.

Semin Diagn Pathol 2020 May 16. Epub 2020 May 16.

Director of Hematopathology, Department of Pathology & Laboratory Medicine, Yale University School of Medicine, 310 Cedar Street, New Haven, CT, 06510, United States. Electronic address:

While the lung is frequently involved by systemic lymphoma, primary pulmonary lymphoma accounts for less than 1% of all extranodal ymphomas. In particular, T-cell lymphoma is very rare in the lung, as a primary or secondary lesion. Patients with pulmonary T-cell lymphoma usually present with cough, dyspnea, pain, fever, recurrent infections, and hemoptysis. Read More

Blood 2020 May 21. Epub 2020 May 21.

Unversity of Pittsburgh School of Medicine, Pittsburgh, Pennsylvania, United States.

The signal transducer and activator of transcription 6 (STAT-6) is a critical up-stream mediator of IL-13 and IL-4 signaling and is constitutively activated in malignant lymphocytes from Sezary syndrome (SS) and mycosis fungoides (MF), the most common subtypes of cutaneous T-cell lymphomas. By combining genome-wide expression profiling with pharmacological STAT-6 inhibition, we have identified the genes regulated by STAT-6 in MF/SS tumors. We found that STAT-6 regulates several common pathways in MF/SS malignant lymphocytes that are associated with control of cell cycle progression and genomic stability as well as production of Th2 cytokines. Read More

Curr Hematol Malig Rep 2020 May 20. Epub 2020 May 20.

City of Hope National Medical Center, 1500 E. Duarte Road, Duarte, CA, 91010, USA.

Purpose Of Review: Primary cutaneous CD30+ T-cell lymphoproliferative disorders (CD30+ LPDs) are the second most common cutaneous lymphomas after mycosis fungoides and Sezary syndrome. They include primary cutaneous anaplastic large cell lymphoma (pcALCL), lymphomatoid papulosis (LyP), and borderline lesions. The purpose of this literature review is to consolidate the available evidence on the primary cutaneous CD30+ LPD in order to define the tools for correct diagnosis and appropriate treatment. Read More

Korean J Fam Med 2020 May 21. Epub 2020 May 21.

Department of Dermatology, Hospital Raja Perempuan Zainab II, Kota Bahru, Malaysia.

Primary cutaneous lymphomas are rare diseases among the general population, and even rarer in children. Mycosis fungoides (MF) is the most commonly diagnosed form in childhood. Several atypical clinical variants of MF have been reported, and pityriasis lichenoides-like MF (PL-like MF) is a recently described subtype. Read More

J Am Acad Dermatol 2020 May 16. Epub 2020 May 16.

Department of Dermatology and Cutaneous Biology, Thomas Jefferson University, Philadelphia, PA. Electronic address:

Background: Topical corticosteroids alone or in combination with other therapies are widely used to treat Mycosis Fungoides (MF), but data on response rates to their use as monotherapy in MF are limited.

Objective: Evaluate the efficacy of topical corticosteroid monotherapy in MF; compare gender, age, stage distributions, and histopathological features between responders and non-responders.

Methods: A retrospective cross-sectional review of MF patients from 2013 to 2019 treated at Thomas Jefferson University was conducted. Read More

Acta Derm Venereol 2020 May 18. Epub 2020 May 18.

Department of Dermatology, Tel Aviv Sourasky Medical Center, Sackler Faculty of Medicine, Tel Aviv University, 64239 Tel Aviv, Israel. E-mail:

F1000Res 2020 5;9. Epub 2020 May 5.

Department of Dermatology, Medical University of Vienna, Währinger Gürtel 18-20, Vienna, 1090, Austria.

Cutaneous T-cell lymphomas (CTCLs) comprise a heterogeneous group of extranodal non-Hodgkin lymphomas involving primarily the skin and mycosis fungoides is its most frequent entity. Whereas most patients show an indolent course in early disease (clinical stages IA to IIA), some patients progress to advanced disease (stage IIB or higher), and the 5-year survival rate is unfavorable: only 47% (stage IIB) to 18% (stage IVB). Except for allogeneic stem cell transplantation, there is currently no cure for CTCL and thus treatment approaches are palliative, focusing on patients' health-related quality of life. Read More

Cancers (Basel) 2020 May 13;12(5). Epub 2020 May 13.

LEO Foundation Skin Immunology Research Center, Department of Immunology and Microbiology, University of Copenhagen, DK-2200 Copenhagen, Denmark.

Cutaneous T-cell lymphoma (CTCL) represents a heterogeneous group of potentially devastating primary skin malignancies. Despite decades of intense research efforts, the pathogenesis is still not fully understood. In the early stages, both clinical and histopathological diagnosis is often difficult due to the ability of CTCL to masquerade as benign skin inflammatory dermatoses. Read More

J Dermatolog Treat 2020 May 25:1-6. Epub 2020 May 25.

Center for Dermatology Research, Department of Dermatology, Wake Forest School of Medicine, Winston-Salem, NC, USA.

Systemic methotrexate (MTX) is a useful treatment for many dermatologic conditions, however, the risk of adverse events prevents its use in patients with minimal or localized disease. Topical application of MTX may be an option to avoid the systemic adverse effects of oral MTX.: To assess what is known about the efficacy and safety of topical methotrexate. Read More

Microsurgery 2020 May 15. Epub 2020 May 15.

Depatment of Hand and Plastic Surgery, Cantonal Hospital of Lucerne, Lucerne, Switzerland.

Soft tissue defects in the buttock area are often related to decubitus ulcers, which are usually small to medium-large size and can be regularly treated with local flaps. However, when the defects have bigger size, such as those involving the whole gluteal region, the coverage can become more challenging, since this specific area needs both a good resistance to pressure and an acceptable functional result. The most common solution for similar cases is the use of multiple local flaps, or, in extreme situations, a free flap. Read More

Dermatol Ther 2020 May 14:e13585. Epub 2020 May 14.

Faculty of Medicine, Department of Pathology, Ankara University, Ankara, Turkey.

Folliculotropic mycosis fungoides (FMF) is characterized by a broad clinical spectrum and worse prognosis compared to classical MF. This study aimed to evaluate the clinical characteristics, treatment modalities and long-term outcome and risk factors for progression and survival of FMF patients. We conducted a single-center retrospective study and reviewed 53 patients diagnosed with FMF between 1990 to 2019 in a referral center at Ankara University, Turkey. Read More

Int J Dermatol 2020 May 13. Epub 2020 May 13.

Department of Dermatology, Firat University Hospital, Elazig, Turkey.

Background: The use of dermoscopy for the evaluation of various inflammatory dermatoses has witnessed a gradual increase in recent years. The present study describes and highlights the importance of dermoscopic findings in the differential diagnosis of plaque psoriasis (PP), lichen planus (LP), mycosis fungoides (MF), pityriasis rosea (PR), and nummular dermatitis (ND) that mostly involve the trunk.

Methods: The study included 150 cases (PP:50, LP:30, MF:20, PR:30, ND:20). Read More

Dermatol Ther 2020 May 11:e13478. Epub 2020 May 11.

National and Kapodistrian University of Athens, Medical School, 2nd Department of Radiology, Radiotherapy Unit, ATTIKON University Hospital. Athens, Greece.

Australas J Dermatol 2020 May 10. Epub 2020 May 10.

Pitney Dermatology, Toowong, Brisbane, Queensland, Australia.

Background: The therapeutic value of ultraviolet A1 (UVA1) phototherapy has been acknowledged for many years. Initially developed predominately for experimental and diagnostic purposes, it was subsequently recognised as a beneficial therapeutic modality in atopic dermatitis and localised scleroderma, and more recently a variety of sclerosing and fibrosing dermatoses, T-lymphocyte mediated disorders, both inflammatory and infiltrative, and several predominately dermal processes previously unresponsive to current therapies.

Methods: We present a retrospective evaluation of outcomes and treatment tolerability in adult patients using a low dose (30 joules/cm ), regimen administered in our private dermatologic practice, between 2006 and December 2019. Read More

JAAD Case Rep 2020 May 30;6(5):434-437. Epub 2020 Apr 30.

Department of Dermatology, Yale School of Medicine, New Haven, Connecticut.

J Natl Compr Canc Netw 2020 May;18(5):522-536

14Stanford Cancer Institute.

Mycosis fungoides (MF) is the most common subtype of cutaneous T-cell lymphoma (CTCL), and Sézary syndrome (SS) is a rare erythrodermic and leukemic subtype of CTCL characterized by significant blood involvement. Although early-stage disease can be effectively treated predominantly with skin-directed therapies, systemic therapy is often necessary for the treatment of advanced-stage disease. Systemic therapy options have evolved in recent years with the approval of novel agents such as romidepsin, brentuximab vedotin, and mogamulizumab. Read More

Front Oncol 2020 21;10:514. Epub 2020 Apr 21.

Department of Malignant Hematology, H. Lee Moffitt Cancer Center and Research Institute, Tampa, FL, United States.

Sézary syndrome (SS) is a genetically and clinically distinct entity among cutaneous T-cell lymphomas (CTCL). SS is characterized by more aggressive disease compared to the most common indolent type of CTCL, mycosis fungoides. However, there are limited available genomic data regarding SS. Read More

J Eur Acad Dermatol Venereol 2020 May 4. Epub 2020 May 4.

Department of Dermatology-Venereology, Faculty of Medicine, University of Crete, Heraklion/Crete, Greece.

Background: Retinoids have long been used in the treatment of cutaneous T-cell lymphomas. However, data on acitretin use for mycosis fungoides (MF) are very limited.

Objectives: To evaluate treatment outcomes of acitretin in patients with MF attending three academic referral centers in different regions of Greece. Read More

Dermatol Pract Concept 2020 3;10(2):e2020044. Epub 2020 Apr 3.

State Dermatology Department, Hippokratio General Hospital, Thessaloniki, Greece.

J Cancer Res Ther 2020 Jan-Mar;16(1):196-198

Department of Dermatology, Faculty of Medicine, University of Tokyo, Tokyo, Japan.

J Cancer Res Ther 2020 Jan-Mar;16(1):94-97

Departments of Pathology and Oncology, Kasturba Medical College, M.A.H.E., Mangalore, Karnataka, India.

Background: The clinicomorphology and immunohistochemical features of T-cell lymphomas have been documented.

Aim: The aim of the study was to evaluate the spectrum of clincopathological features of T-cell lymphoma with immunohistochemistry correlation in a tertiary care center.

Materials And Methods: The present study was conducted on 19 biopsy specimens received from the Department of Pathology, Kasturba Medical College, from referral hospitals of Mangalore city. Read More

J Dermatol Sci 2020 Feb 28. Epub 2020 Feb 28.

Department of Dermatology and Cutaneous Biology, Thomas Jefferson University, Philadelphia, PA, United States. Electronic address:

Background: Questionnaire tools are increasingly being used to assess health related quality of life (HRQOL) in mycosis fungoides (MF) patients. However, a thorough understanding of the factors that lead to poor HRQoL in early stage disease and their distribution across patient subgroups is lacking.

Objectives: To characterize factors affecting HRQoL as assessed by Skindex-29 in subgroups of patients with early stage MF seen at a multidisciplinary cutaneous lymphoma clinic. Read More

Dermatol Ther 2020 May 2:e13487. Epub 2020 May 2.

Department of Dermatology, Tohoku University Graduate School of Medicine, Sendai, Japan.

Mogamulizumab shows cytotoxicity against CCR4+ lymphoma cells by antibody-dependent cell-mediated cytotoxicity (ADCC) in advanced cutaneous T-cell lymphoma (CTCL) patients. Although mogamulizumab is used as one of the anchor drugs for the treatment of advanced CTCL, its efficacy is unsatisfactory, especially in mycosis fungoides (MF). Therefore, additional drugs to enhance the antitumor effects of mogamulizumab are needed to further optimize its use for the treatment of MF. Read More

J Cutan Pathol 2020 May 3. Epub 2020 May 3.

Dermatopathology Section, Department of Pathology and Laboratory Medicine, VA Consolidated Laboratories, West Roxbury, MA, USA.

Poikilodermatous plaque-like hemangioma (PPLH) is a recently described benign vasoformative entity with only 16 cases reported to date. We present an additional case of a 90-year-old male who presented with a 2-year history of a relatively large, asymptomatic, atrophic plaque on his left buttock. The lesion was initially smaller and grew before stabilizing in size. Read More

Ann Otol Rhinol Laryngol 2020 Apr 27:3489420916213. Epub 2020 Apr 27.

Department of Surgery, Division of Otolaryngology-Head & Neck Surgery, UC San Diego, San Diego, CA, USA.

Objectives: To report a case of laryngeal involvement of mycosis fungoides and its symptomatic treatment with laser-assisted surgical ablation.

Methods: Case report and literature review.

Results: A 76-year-old woman with longstanding MF previously treated with Brentuximab Vedotin who developed persistent cough and dysphonia. Read More

Dermatology 2020 Apr 24:1-6. Epub 2020 Apr 24.

Department of Dermatology, Aarhus University Hospital, Skejby, Aarhus, Denmark.

Background: Mycosis fungoides (MF), the most common form of cutaneous T-cell lymphoma (CTCL), is a lymphoproliferative disorder characterized by proliferation of malignant T cells in a chronic inflammatory environment in the skin. The nature of MF is still not fully understood, but aberrant microRNA (miR) expression and function seem to play an important role in the pathogenesis and disease progression and have been proposed as a putative disease marker. Recent studies have reported aberrant expression of miR-93 in situin MF lesions and linked dysregulated miR-93 expression to advanced stages of MF. Read More

J Am Acad Dermatol 2020 Apr 22. Epub 2020 Apr 22.

Department of Clinical Haematology, Peter MacCallum Cancer Centre and Royal Melbourne Hospital, Melbourne, Australia; Faculty of Medicine, Nursing, and Health Sciences, Monash University, Clayton, Australia. Electronic address:

J Dermatol 2020 Jun 22;47(6):641-645. Epub 2020 Apr 22.

Departments of, Department of, Dermatology, Wakayama Medical University, Wakayama, Japan.

Lymphomatoid papulosis (LyP) is a self-limiting cutaneous T-cell lymphoproliferative disorder that may progress into malignant lymphoma. Most of the previously reported associated lymphomas are primary cutaneous anaplastic large-cell lymphoma and mycosis fungoides with a low mortality rate. We report a case of primary cutaneous peripheral T-cell lymphoma, not otherwise specified (pcPTCL-NOS), associated with LyP after long-term follow up. Read More

Expert Rev Anticancer Ther 2020 Apr 28:1-6. Epub 2020 Apr 28.

Professor of Dermatology and Director of Cutaneous Lymphoma Program, Department of Dermatology, Perelman School of Medicine at the University of Pennsylvania, Philadelphia, PA, USA.

: Advanced mycosis fungoides (MF) and Sézary syndrome (SS) are forms of cutaneous T-cell lymphoma characterized by a poor prognosis. Treatments are associated with high rates of relapse, and thus there exists an unmet medical need for new, improved therapies. Mogamulizumab is a novel defucosylated monoclonal antibody targeting C-C chemokine receptor 4 that eradicates malignant cells via antibody-dependent cellular cytotoxicity (ADCC). Read More

Cytometry B Clin Cytom 2020 Apr 22. Epub 2020 Apr 22.

Department of Laboratory Medicine, Yale University School of Medicine, New Haven, Connecticut, USA.

A peripheral blood flow cytometric assay for Sézary syndrome (SS) or circulating mycosis fungoides (MF) cells must be able to reliably identify, characterize, and enumerate T-cells with an immunophenotype that differs from non-neoplastic T-cells. Although it is also important to distinguish SS and MF from other subtypes of T-cell neoplasm, this usually requires information in addition to the immunophenotype, such as clinical and morphologic features. This article outlines the approach recommended by an international group with experience and expertise in this area. Read More

J Ultrasound Med 2020 Apr 22. Epub 2020 Apr 22.

Department of Dermatology, Peking Union Medical College Hospital, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing, China.

Objectives: This study was aimed to assess the ultrasound (US) characteristics of mycosis fungoides (MF)/Sézary syndrome (SS) and explore the value of high-frequency US in accuracy staging for classic mycosis fungoides (cMF).

Methods: A prospective study was designed. Twenty-six patients with histopathologically confirmed MF or SS were enrolled to undergo HF-US examinations. Read More

An Bras Dermatol 2020 May - Jun;95(3):326-331. Epub 2020 Mar 20.

Postgraduate Program in Anatomical Pathology, Faculdade de Medicina, Universidade Federal do Rio de Janeiro, Rio de Janeiro, RJ, Brazil; Department of Pathology, Faculdade de Medicina, Universidade Federal do Rio de Janeiro, Rio de Janeiro, RJ, Brazil; Instituto Nacional de Infectologia, Fundação Oswaldo Cruz, Rio de Janeiro, RJ, Brazil.

Background: Diagnosis of mycosis fungoides is challenging due to the non-specificity of clinical and histopathological findings. The literature indicates an average delay of 4-6 years for a conclusive diagnosis. Refinement of the histopathological criteria for the diagnosis of patients in early stages of the disease is considered of interest. Read More

J Am Acad Dermatol 2020 Apr 16. Epub 2020 Apr 16.

Department of Dermatology, Columbia University Irving Medical Center, New York, New York. Electronic address:

Eur J Dermatol 2020 Apr 16. Epub 2020 Apr 16.

2nd Department of Dermatology and Venereal Diseases, Attikon General University Hospital, Medical School, National and Kapodistrian University of Athens, Athens, Greece.

Cutaneous T-cell lymphoma is a heterogeneous group of non-Hodgkin's lymphoma, characterized by an infiltration of malignant T cells in the skin. The most common subgroups include mycosis fungoides followed by the aggressive leukaemic variant, Sézary syndrome. The pathophysiology of this neoplasm is poorly understood. Read More