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    Mogamulizumab-induced phosensitivity in patients with mycosis fungoides and other T cell neoplasms.
    J Eur Acad Dermatol Venereol 2018 Jan 16. Epub 2018 Jan 16.
    Department of Dermatology, Hamamatsu University School of Medicine.
    Background: Mogamulizumab (Mog) is a defucosylated, therapeutic monoclonal antibody, targeting CCR4, and was first approved in Japan for the treatment of adult T cell leukaemia/lymphoma (ATLL), followed by cutaneous T cell lymphoma and peripheral T cell lymphoma.

    Objective: To retrospectively investigate development of photosensitivity in patients with mycosis fungoides and other T cell neoplasms after treatment with Mog.

    Methods: We treated 7 cutaneous lymphoma patients with Mog. Read More

    Sézary syndrome managed with histone deacetylase inhibitor followed by anti-CCR4 monoclonal antibody.
    Clin Exp Dermatol 2018 Jan 12. Epub 2018 Jan 12.
    Department of Dermatology, Tokyo Medical University, Tokyo, Japan.
    A 70-year-old man presented to our clinic with a 10-year history of recurrent pruritic erythema and plaques on his trunk and limbs. Based on the pathological findings and monoclonal rearrangement of the T-cell receptor (TCR)-Cβ1 gene, mycosis fungoides (T2N0M0B0 stage IB) was diagnosed. Despite combination therapy including histone deacetylase inhibitor (vorinostat), the symptoms slowly evolved into Sézary syndrome (SS; T4N1M0B2) over 4 years, with dense infiltrates due to atypical lymphocytes expressing CCR4 developing in the entire dermis. Read More

    Synchronous Occurrence of Mycosis Fungoides, Diffuse Large B cell Lymphoma and Acute Myeloid Leukemia: A Report of Two Cases.
    Intern Med 2018 Jan 11. Epub 2018 Jan 11.
    Department of Hematology and Rheumatology, Kindai University Faculty of Medicine, Japan.
    Patients with mycosis fungoides (MF), the most common subtype of primary cutaneous T-cell lymphoma, have an increased risk of developing secondary malignancies. We herein report two rare cases of MF concurring with diffuse large B cell lymphoma (B lymphoid lineage) and acute myeloid leukemia (myeloid lineage) in two otherwise healthy elderly patients. Potential etiologic factors, including the impact of the therapy-associated inflammatory response on the development of secondary tumors in patients with MF, are discussed. Read More

    How to Discern Folliculotropic Mycosis Fungoides From Follicular Mucinosis Using a Pediatric Case.
    J Cutan Med Surg 2018 Jan 1:1203475417752366. Epub 2018 Jan 1.
    3 Department of Dermatology, University of Texas MD Anderson Cancer Center, Houston, TX, USA.
    Folliculotropic mycosis fungoides (FMF) is a variant of mycosis fungoides (MF) with folliculotropic, atypical lymphocytes that may or may not have mucin deposition surrounding the hair follicle. Follicular mucinosis (FM) is a primary or secondary finding in FMF, lupus, or collagen vascular diseases that is only a histological process of mucin deposition surrounding the hair follicles. We present a case of a 6-year-old boy who had features of both FMF and primary follicular mucinosis (PFM). Read More

    Hypopigmented mycosis fungoides: a 20-case retrospective series.
    Int J Dermatol 2018 Jan 10. Epub 2018 Jan 10.
    Sector of Dermatology, Post-Graduation Course in Dermatology and Post Graduation Program in Medical Clinics, University Hospital and School of Medicine, Federal University of Rio de Janeiro, Rio de Janeiro, Brazil.
    Background: Hypopigmented mycosis fungoides (hMF) is a rare subtype of mycosis fungoides. The aim of this study was to identify the clinical-epidemiological profile of our patient group and also to provide additional information about treatment responses and prognosis.

    Methods: This is a cross-sectional retrospective observational study, with exploratory analysis. Read More

    Dermoscopic characterization of cutaneous lymphomas: a pilot survey.
    Int J Dermatol 2018 Jan 10. Epub 2018 Jan 10.
    Department of Dermatology, University of Iowa Hospitals & Clinics, Iowa City, IA, USA.
    Background: While substantial dermoscopic analysis of melanocytic lesions has been performed, dermoscopic characterization of cutaneous lymphoid proliferations has been limited. Cutaneous lymphoma, particularly early mycosis fungoides (MF) and its variants, is often challenging to clinically and pathologically distinguish from inflammatory processes of the skin. This study aimed to survey the dermoscopic findings of cutaneous lymphomas and to discern whether any patterns might potentially serve as specific signatures. Read More

    Etoposide as a single agent in the treatment of mycosis fungoides: A retrospective analysis.
    Dermatol Ther 2018 Jan 9. Epub 2018 Jan 9.
    Department of Dermatology, Indiana University School of Medicine, Indianapolis, Indiana.
    Several chemotherapy agents have shown efficacy in the treatment of mycosis fungoides (MF). In the literature, there is limited data on the use of single agent etoposide for MF. We aimed to retrospectively review our experience with single agent etoposide in the treatment of advanced-stage or refractory early-stage MF with focus on analyzing its efficacy and safety. Read More

    Increased interleukin-36γ expression in skin and sera of patients with atopic dermatitis and mycosis fungoides/Sézary syndrome.
    J Dermatol 2018 Jan 3. Epub 2018 Jan 3.
    Department of Dermatology, University of Tokyo Graduate School of Medicine, Tokyo, Japan.
    Interleukin (IL)-36γ is expressed by keratinocytes and functions as a key initiator of inflammation in the skin. IL-36γ expression is enhanced by tumor necrosis factor-α and IL-17A, having a strong association with psoriasis. In this study, we examined the role of IL-36γ in atopic dermatitis (AD) and mycosis fungoides (MF)/Sézary syndrome (SS). Read More

    Current systemic therapeutic options for advanced mycosis fungoides and Sézary syndrome.
    Leuk Lymphoma 2018 Mar 8;59(3):562-577. Epub 2018 Jan 8.
    d Department of Medicine, Section of Dermatology , University of Chicago Medicine and Biological Sciences , Chicago , IL , USA.
    Mycosis fungoides (MF) and Sézary syndrome (SS) are the most common cutaneous T-cell lymphomas (CTCLs). Both lack curative options, and advanced-stage carries a poor prognosis. Whilst there are a number of treatments available, achieving and maintaining a durable remission remains challenging. Read More

    Progression of undiagnosed cutaneous lymphoma after anti-tumor necrosis factor alpha therapy.
    J Am Acad Dermatol 2018 Jan 4. Epub 2018 Jan 4.
    Department of Dermatology, Northwestern University, Feinberg School of Medicine, Northwestern Medicine, Chicago, IL. Electronic address:
    Background: Cutaneous lymphoma (CL) diagnosed after anti-tumor necrosis factor (TNF)α therapy has been reported in the literature, yet a clear link between both events remains elusive.

    Objective: To review our experience with CL diagnosed during or after the use of anti-TNFα therapies.

    Methods: This is a multicenter retrospective study and a literature review. Read More

    Mycosis fungoides occurring at the site of previous herpes zoster eruption.
    Australas J Dermatol 2017 Dec 26. Epub 2017 Dec 26.
    Department of Dermatology, University of Texas MD Anderson Cancer Center, Houston, Texas, USA.
    Numerous clinicopathological variants of mycosis fungoides have been described in the literature. Dermatomal or zosteriform mycosis fungoides is one reported variant but a clear aetiology has never been documented. We report a case of mycosis fungoides proved by biopsy and immunohistochemistry that developed in a 55-year-old man at the site of previous herpes zoster eruption. Read More

    Hyperpigmentation as a peculiar presentation of mycosis fungoides.
    An Bras Dermatol 2017 ;92(5 Suppl 1):92-94
    Department of Dermatology, Kaohsiung Veterans General Hospital - Kaohsiung, Taiwan.
    Hyperpigmented mycosis fungoides is an extremely rare subtype of mycosis fungoides. It presents as multiple pigmented macules and patches without poikilodermatous changes and characterized by a CD8+ phenotype on immunohistochemistry. This report describes a typical case of hyperpigmented mycosis fungoides in a 62-year-old woman, who presented with a 7-year history of multiple hyperpigmented macules and patches on the trunk and right leg with progression over this half a year. Read More

    Folliculotropic mycosis fungoides: challenging clinical, histopathological and immunohistochemical diagnosis.
    An Bras Dermatol 2017 ;92(5 Suppl 1):73-75
    Department of Morphology, Universidade Federal de Juiz de Fora (UFJF) - Juiz de Fora (MG), Brazil.
    Mycosis fungoides is a cutaneous T-cell lymphoma with various clinical and pathological presentations. Early lesions are nonspecific, which hinders early diagnosis. The folliculotropic subtype is manifested as acneiform lesions, follicular papules or erythematous plaques mainly on the face, neck and upper trunk. Read More

    Combination of low-dose total skin electron beam therapy and subsequent localized skin electron beam therapy as a therapeutic option for advanced-stage mycosis fungoides.
    Clin Exp Dermatol 2017 Dec 21. Epub 2017 Dec 21.
    Department of Dermatology, Keio University School of Medicine, Tokyo, Japan.
    Electron beam therapy (EBT) is an established treatment for mycosis fungoides (MF), but evidence for the use of EBT in advanced cutaneous conditions is limited, and optimal scheduling of the regimen for such conditions remains unclear. We report the case of a 44-year-old woman diagnosed with MF with widespread cutaneous lesions, including multiple huge tumours in the craniofacial area. Low-dose total skin (TS)EBT and subsequent localized skin (LS)EBT achieved striking improvements in eruptions. Read More

    Blueprint unknown: a case for multidisciplinary management of advanced penile mycosis fungoides.
    Can J Urol 2017 Dec;24(6):9139-9144
    Department of Surgery, Austin Health, The University of Melbourne, Victoria, Australia.
    A 64-year-old man presented with a 2 week history of progressive phimosis and painful ulcer on his penile meatus. He underwent penile preserving excision, and subsequent pathological examination confirmed T-cell non-Hodgkin lymphoma with immunohistochemical features of large cell transformation of mycosis fungoides. The penis was further treated with local external beam radiotherapy consisting of 27 Gy in 15 fractions and systemic mini-CHOP chemotherapy. Read More

    Nodal Involvement by CD30+ Cutaneous Lymphoproliferative Disorders and Its Challenging Differentiation From Classical Hodgkin Lymphoma.
    Arch Pathol Lab Med 2018 Jan;142(1):139-142
    From the Department of Pathology, Mount Sinai St Luke's, Icahn School of Medicine at Mount Sinai, New York, New York (Dr Lezama); and the Department of Pathology, Stanford University School of Medicine, Stanford, California (Dr Gratzinger).
    Primary cutaneous lymphomas are defined as non-Hodgkin lymphomas that present in the skin with no evidence of extracutaneous disease at the time of diagnosis. Mycosis fungoides is the most common type of primary cutaneous T-cell lymphoma, representing almost 50% of primary cutaneous T-cell lymphomas, and primary cutaneous CD30+ T-cell lymphoproliferative disorders are the second most common group (30%). Transformed mycosis fungoides is usually CD30+ and can involve multiple nodal sites; other primary cutaneous CD30+ T-cell lymphoproliferative disorders can also involve draining regional nodes. Read More

    Folliculotropic Mycosis Fungoides Associated with Autoimmune Hepatitis.
    Acta Dermatovenerol Croat 2017 Oct;25(3):248-250
    Prof. Romana Čeović, MD, PhD, University Hospital Center Zagreb, Department of Dermatology and Venereology School of Medicine, University of Zagreb, 10000 Zagreb, Šalata 4, Croatia;
    Dear Editor, the association between lymphomas and autoimmune manifestations, as well as the prevalence of the cases of coexistent lymphomas and autoimmune conditions, has not been completely established (1-3). Since cutaneous T-cell lymphoma (CTCL) cases are rare, any hypothesis can only be based on case reports or small case series. We present the case of a male patient with folliculotropic mycosis fungoides (FMF) and synchronous autoimmune hepatitis (AIH) with extremely high levels of cancer antigen 19-9 (CA 19-9). Read More

    Analysis of CTCL cell lines reveals important differences between mycosis fungoides/Sézary syndrome vs. HTLV-1+ leukemic cell lines.
    Oncotarget 2017 Nov 7;8(56):95981-95998. Epub 2017 Oct 7.
    Division of Dermatology, McGill University, Montréal, Québec, Canada.
    HTLV-1 is estimated to affect ~20 million people worldwide and in ~5% of carriers it produces Adult T-Cell Leukemia/Lymphoma (ATLL), which can often masquerade and present with classic erythematous pruritic patches and plaques that are typically seen in Mycosis Fungoides (MF) and Sézary Syndrome (SS), the most recognized variants of Cutaneous T-Cell Lymphomas (CTCL). For many years the role of HTLV-1 in the pathogenesis of MF/SS has been hotly debated. In this study we analyzed CTCL vs. Read More

    Relationship Between Pityriasis Lichenoides and Mycosis Fungoides: A Clinicopathological, Immunohistochemical, and Molecular Study.
    Am J Dermatopathol 2017 Nov 22. Epub 2017 Nov 22.
    Departments of Dermatology.
    Background: Several cases of pityriasis lichenoides (PL) have been reported to evolve into mycosis fungoides (MF).

    Objective: To elucidate clues to this progression.

    Methods: Fifty-eight patients with PL between 2000 and 2013 (follow-up: 3-16 years, average: 8. Read More

    Prognostic miRNA classifier in early-stage mycosis fungoides: development and validation in a Danish nationwide study.
    Blood 2017 Dec 5. Epub 2017 Dec 5.
    Department of Dermatology, Aarhus University Hospital, Aarhus, Denmark.
    Mycosis fungoides (MF) is the most frequent form of cutaneous T-cell lymphoma. The disease often takes an indolent course, but in approximately one third of the patients, the disease progresses to an aggressive malignancy with a poor prognosis. At the time of diagnosis, it is impossible to predict which patients develop severe disease and are in need of aggressive treatment. Read More

    Therapeutic and prognostic significance of PARP-1 in advanced mycosis fungoides and Sezary syndrome.
    Exp Dermatol 2017 Dec 5. Epub 2017 Dec 5.
    Department of Dermatology, University of Pittsburgh, Pittsburgh, PA, USA.
    While mycosis fungoides (MF) is typically an indolent malignancy, it may infrequently undertake an aggressive course. We used proteomic analyses to identify a biomarker of the aggressive course of MF. Results of this investigation demonstrated that PARP-1, heat-shock protein family A (Hsp70) member 1 like (HSAP1L), Hsp70 member 1A (HSPA1A), ATP-depending RNA helicase (DDX17) and the α-isoform of lamina-associated polypeptide 2 (TMPO) had higher expression in aggressive disease versus non-aggressive. Read More

    Therapeutic reduction of cell-mediated immunosuppression in mycosis fungoides and Sézary syndrome.
    Cancer Immunol Immunother 2017 Dec 4. Epub 2017 Dec 4.
    Department of Dermatology, University of Pittsburgh, Suite 500.68 Medical Arts Building, 3708 Fifth Avenue, Pittsburgh, PA, 15213, USA.
    Tumor progression is associated with progressive immunosuppression mediated in part by T regulatory cell(s) (Treg) and/or myeloid-derived suppressor cell(s) (MDSC). Development of strategies to reduce populations of immune cells with suppressive function in cancer patients may enable the induction or recovery of immunity against tumor cells, which may limit or reverse disease progression. With a goal of developing Treg and MDSC neutralizing strategies to treat mycosis fungoides (MF) and Sézary syndrome (SzS), we determined the association between disease stage and suppressor cell populations in patients with MF/SzS, including those responding to therapy. Read More

    Risk of venous thromboembolism in patients with mycosis fungoides and parapsoriasis: A Danish nationwide population-based cohort study.
    J Am Acad Dermatol 2017 Dec 1. Epub 2017 Dec 1.
    Department of Dermatology, Aarhus University Hospital, Aarhus, Denmark.
    Background: Mycosis fungoides (MF) and parapsoriasis are characterized by malignant proliferation and chronic inflammation, which may impact the risk of venous thromboembolism (VTE).

    Objectives: To examine the risk of VTE in patients with MF and parapsoriasis.

    Methods: We conducted a nationwide population-based cohort study in Denmark to examine the relative risk (RR) of VTE in 525 patients with MF and 634 patients with parapsoriasis compared with sex- and age-matched controls from the general population. Read More

    Red tattoo-related mycosis fungoides-like CD8+ pseudolymphoma.
    J Cutan Pathol 2017 Nov 28. Epub 2017 Nov 28.
    Department of Dermatology, Mayo Clinic, Rochester, Minnesota.
    Cutaneous reactions to red tattoo pigment rarely manifest as pseudolymphomatous reactions. We describe an exceedingly rare case of red tattoo-related T-cell predominant pseudolymphoma microscopically mimicking mycosis fungoides. Careful clinicopathological correlation was required to obtain the correct diagnosis and aid in an effective treatment course. Read More

    Incidence and ten-year follow-up of primary cutaneous lymphomas: a single-centre cohort study.
    Eur J Dermatol 2017 Nov 24. Epub 2017 Nov 24.
    Department of Medicine, Section of Dermatology and Venereology, University of Verona, Verona, Italy.
    Background: Primary cutaneous lymphomas (PCLs) are a rare group of extranodal non-Hodgkin lymphomas, and epidemiological data in Mediterranean countries are scarce.

    Objective: To investigate the incidence and characteristics of PCL in a single tertiary referral centre in Italy.

    Materials & Methods: A total of 141 PCL patients, seen over a 10-year follow-up period, were investigated. Read More

    Folliculotropism Does Not Affect Overall Survival in Mycosis Fungoides: Results from a Single-Center Cohort and Meta-Analysis.
    Dermatology 2017 Nov 24. Epub 2017 Nov 24.
    Division of Dermatology, University of Alberta, Edmonton, AB, Canada.
    Background: Folliculotropic mycosis fungoides (FMF) is a distinct subtype of mycosis fungoides (MF) with unique clinicopathological features. The medical literature suggests that FMF has a more aggressive course and worse survival than classic MF. Previous studies do not use standardized treatment, and no studies have reported an association between treatment response and overall survival (OS). Read More

    Granulomatous slack skin: a rare subtype of mycosis fungoides.
    An Bras Dermatol 2017 Sep-Oct;92(5):694-697
    General Outpatient Dermatology Clinic at Instituto Lauro de Souza Lima (ILSL) - Bauru (SP), Brazil.
    We report a case of granulomatous slack skin, a rare and indolent subtype of mycosis fungoides. It affects mainly men between the third and fourth decades. It is characterized by hardened and erithematous plaques that mainly affect flexural areas and become pedunculated after some years. Read More

    Primary cutaneous T-cell lymphoma: experience from the Peruvian National Cancer Institute.
    An Bras Dermatol 2017 Sep-Oct;92(5):649-654
    Medical Oncology Service, Instituto Nacional de Enfermedades Neoplásicas (INEN) - Surquillo, Peru.
    Background: Primary cutaneous T-cell lymphomas constitute a heterogeneous and rare group of diseases with regional particularities in Latin America.

    Objective: To determine the clinicopathological features, relative frequency and survival among patients from a Peruvian institution.

    Methods: Primary cutaneous T-cell lymphomas were defined based on the absence of extracutaneous disease at diagnosis. Read More

    Juvenile mycosis fungoides with large-cell transformation: Successful treatment with psoralen with ultraviolet A light, interferon-alfa, and localized radiation.
    Pediatr Dermatol 2017 Nov 21. Epub 2017 Nov 21.
    Department of Dermatology, MD Anderson Cancer Center, University of Texas, Houston, TX, USA.
    Mycosis fungoides with large-cell transformation is historically associated with a poor prognosis. Pediatric cases of mycosis fungoides with large-cell transformation are rare, with only three other cases reported in the literature. We present the first case of a child with almost complete remission of his mycosis fungoides with large-cell transformation shortly after administration of psoralen plus ultraviolet A, interferon-alfa, and localized radiation. Read More

    Aprepitant improves refractory pruritus in primary cutaneous T-cell lymphomas: experience of the Spanish Working Group on Cutaneous Lymphomas.
    Br J Dermatol 2017 Nov 18. Epub 2017 Nov 18.
    Departments of Dermatology: Hospital Universitario 12 de Octubre, Instituto de Investigación i+12, Universidad Complutense-Madrid.
    Aprepitant has shown a promising anti-itch activity in several cases of cutaneous T-cell lymphomas (CTCLs)1-8 . We sought to determine its antipruritic efficacy in a large multicenter series of CTCLs patients with refractory pruritus and, secondarily, to define possible clinical predictors of response.A retrospective, analytical review of the Spanish Working Group on Cutaneous Lymphoma database was designed to collect patients with CTCLs and refractory pruritus, treated with aprepitant from 2009 to 2013. Read More

    Mycosis Fungoides Manifesting as Giant Cell Lichenoid Dermatitis.
    Am J Dermatopathol 2017 Nov 10. Epub 2017 Nov 10.
    *Department of Dermatology, Medical Military Academy, Saint Petersburg, Russia; †Department of Pathology, North-Western State Medical University, Saint Petersburg, Russia; and ‡Sikl's Department of Pathology, Medical Faculty in Pilsen, Charles University in Prague, Pilsen, Czech Republic.
    Mycosis fungoides (MF) is the most common form of primary cutaneous lymphoma with a broad clinicopathological spectrum. Unusual histopathologic patterns of MF include lichenoid, interstitial, folliculotropic, spongiotic, granulomatous, and many others. Several cases of unusual lichenoid reaction characterized by a mixed lichenoid inflammatory infiltrate with prominent infiltration of the papillary dermis and epidermis by multinucleated giant cells were described under the name of "giant cell lichenoid dermatitis," most of them were considered to represent a drug eruption. Read More

    Unilesional Follicular Mycosis Fungoides: Report of 6 Cases and Review of the Literature.
    Am J Dermatopathol 2017 Oct 24. Epub 2017 Oct 24.
    *Department of Pathology and Laboratory Medicine, Weill Cornell Medicine, New York, NY; †Division of Dermatology, Memorial Hospital of Rhode Island, The Warren Alpert Medical School of Brown University, Providence, RI; and ‡Department of Pathology and Laboratory Medicine, Dartmouth-Hitchcock Medical Center, Lebanon, NH.
    Unilesional follicular mycosis fungoides (MF) is a rare variant of cutaneous T-cell lymphoma characterized by selective involvement of the hair follicles by neoplastic T lymphocytes presenting initially as a solitary lesion occupying less than 5% of the body surface; there are 22 previous reported cases. We describe 6 patients with this rare variant of MF, all males (age range 6-64 years; mean age: 28 years) presenting with a solitary lesion primarily on the face and scalp except 1 patient who presented with a truncal lesion. All the patients had the lesions for at least a few months. Read More

    Unrelated immunodeficiency states may impact outcomes and immune checkpoint molecule expression in patients with mycosis fungoides: A clinicopathologic case-control study.
    J Am Acad Dermatol 2017 Nov 10. Epub 2017 Nov 10.
    Department of Pathology, Dermatopathology Service, Memorial Sloan Kettering Cancer Center, New York, New York. Electronic address:
    Background: Immunodeficiency (ID) correlates with worse outcomes and decreased immune checkpoint molecule expression in melanoma. The impact of ID in mycosis fungoides (MF) is unknown.

    Objective: Our goal was to evaluate the impact of ID in MF. Read More

    Role of dysregulated cytokine signaling and bacterial triggers in the pathogenesis of Cutaneous T Cell Lymphoma.
    J Invest Dermatol 2017 Nov 8. Epub 2017 Nov 8.
    Department of Pathology, NYU School of Medicine, New York, NY 10016; Laura and Isaac Perlmutter Cancer Institute, NYU School of Medicine; New York, NY 10016. Electronic address:
    Cutaneous T cell lymphoma is a heterogeneous group of lymphomas characterized by the accumulation of malignant T cells in the skin. The molecular and cellular etiology of this malignancy remains enigmatic and what role antigenic stimulation plays in the initiation and/or progression of the disease remains to be elucidated. Deep sequencing of the tumor genome revealed a highly heterogeneous landscape of genetic perturbations and transcriptome analysis of transformed T cells further highlighted the heterogeneity of this disease. Read More

    Mycosis fungoides - A cutaneous lymphoproliferative disorder in a patient treated with fingolimod for multiple sclerosis.
    J Clin Neurosci 2018 Feb 3;48:102-103. Epub 2017 Nov 3.
    Department of Neurology, Barzilai University Medical Center, Ashkelon, Israel; Faculty of Health Sciences, Ben Gurion University of the Negev, Beer-Sheva, Israel.
    Fingolimod was the first oral disease-modifying drug approved for the treatment of relapsing-remitting multiple sclerosis (MS). It has previously been associated with rare cases of lymphoma. Here we describe the first case of mycosis fungoides - a cutaneous lymphoproliferative disorder, in an MS patient treated with fingolimod. Read More

    Standardization of regimens in Narrow-band UVB and PUVA in early stage Mycosis Fungoides: position paper from the Italian Task Force for Cutaneous Lymphomas.
    J Eur Acad Dermatol Venereol 2017 Nov 4. Epub 2017 Nov 4.
    Dermatology Unit Department of Surgery and Translational Medicine, University of Florence Medical School, Italy.
    UV- based (PUVA and Narrow Band UVB) phototherapy is broadly and commonly used in the treatment of Cutaneous T-cell Lymphomas (CTCL), yet unfortunately the evidence for the efficacy of these treatments is based only on cases series or prospective but non-randomized studies. Therefore, no internationally approved guidelines exists and no standardization of schedules have been proposed. Recently, Consensus guidelines have been published by the United States Cutaneous Lymphoma Consortium. Read More

    Hodgkin's lymphoma arising in a case of mycosis fungoides: An unusual association.
    Indian J Dermatol Venereol Leprol 2017 Nov 3. Epub 2017 Nov 3.
    Department of Pathology, Vardhman Mahavir Medical College, Safdarjung Hospital, New Delhi, India.
    Mycosis fungoides is a cutaneous T-cell lymphoma with a high risk for developing secondary malignancies, especially B-cell lymphoproliferative disorders. About 40 cases of Hodgkin's lymphoma associated with mycosis fungoides have been reported in literature till date. We report a case of a 35-year-old gentleman who presented with intensely itchy reddish lesions all over the body. Read More

    Folliculotropic mycosis fungoides presenting with a solitary lesion: Clinicopathological features and long-term follow-up data in a series of 9 cases.
    J Cutan Pathol 2018 Feb 11;45(2):122-128. Epub 2017 Dec 11.
    Departments of Dermatology, Leiden University Medical Center, Leiden, The Netherlands.
    Background: Folliculotropic mycosis fungoides (FMF) is a distinct variant of mycosis fungoides, which in rare cases may present with a solitary lesion. Reported cases describe an excellent prognosis, but follow up was generally short. Herein, clinicopathologic characteristics, long-term follow-up data of 9 patients with solitary FMF are presented and differential diagnosis is discussed. Read More

    Thinking about CNS metastasis in cutaneous lymphoma: Analysis of existing data.
    Leuk Res Rep 2017 16;8:14-18. Epub 2017 Oct 16.
    Department of Dermatology, UT Southwestern Medical Center, 5323 Harry Hines Blvd., MSC 9069, Dallas, TX 75390-9069, USA.
    To determine some of the key clinical features that help prompt clinicians to pursue additional work-up for evaluation of CNS involvement of MF, we conducted a systematic review to better define characteristics, treatments, outcomes, and mortality in these patients. Our analyses indicated that neurologic surveillance after the diagnosis of MF is crucial. Review of systems should include change in mentation, vestibular, and ocular symptoms. Read More

    Regional incidences of adult T-cell leukemia/lymphoma with cutaneous involvement in Japan.
    J Dermatol 2018 Jan 25;45(1):58-63. Epub 2017 Oct 25.
    Departments of Dermatology, Okayama University Graduate School of Medicine, Dentistry and Pharmaceutical Sciences, Okayama, Japan.
    Between 2008 and 2015, 462 newly-diagnosed adult T-cell leukemia/lymphoma (ATLL) patients with cutaneous involvement were found from the nationwide registry for Japanese patients with cutaneous lymphoma, of which 391 were selected for the study. They ranged in age from 28 to 93 years (median, 69 years), and included 215 men and 176 women (male : female ratio = 1.2). Read More

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