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    Mycosis Fungoides Manifesting as Giant Cell Lichenoid Dermatitis.
    Am J Dermatopathol 2017 Nov 10. Epub 2017 Nov 10.
    *Department of Dermatology, Medical Military Academy, Saint Petersburg, Russia; †Department of Pathology, North-Western State Medical University, Saint Petersburg, Russia; and ‡Sikl's Department of Pathology, Medical Faculty in Pilsen, Charles University in Prague, Pilsen, Czech Republic.
    Mycosis fungoides (MF) is the most common form of primary cutaneous lymphoma with a broad clinicopathological spectrum. Unusual histopathologic patterns of MF include lichenoid, interstitial, folliculotropic, spongiotic, granulomatous, and many others. Several cases of unusual lichenoid reaction characterized by a mixed lichenoid inflammatory infiltrate with prominent infiltration of the papillary dermis and epidermis by multinucleated giant cells were described under the name of "giant cell lichenoid dermatitis," most of them were considered to represent a drug eruption. Read More

    Unilesional Follicular Mycosis Fungoides: Report of 6 Cases and Review of the Literature.
    Am J Dermatopathol 2017 Oct 24. Epub 2017 Oct 24.
    *Department of Pathology and Laboratory Medicine, Weill Cornell Medicine, New York, NY; †Division of Dermatology, Memorial Hospital of Rhode Island, The Warren Alpert Medical School of Brown University, Providence, RI; and ‡Department of Pathology and Laboratory Medicine, Dartmouth-Hitchcock Medical Center, Lebanon, NH.
    Unilesional follicular mycosis fungoides (MF) is a rare variant of cutaneous T-cell lymphoma characterized by selective involvement of the hair follicles by neoplastic T lymphocytes presenting initially as a solitary lesion occupying less than 5% of the body surface; there are 22 previous reported cases. We describe 6 patients with this rare variant of MF, all males (age range 6-64 years; mean age: 28 years) presenting with a solitary lesion primarily on the face and scalp except 1 patient who presented with a truncal lesion. All the patients had the lesions for at least a few months. Read More

    Unrelated immunodeficiency states may impact outcomes and immune checkpoint molecule expression in patients with mycosis fungoides: A clinicopathologic case-control study.
    J Am Acad Dermatol 2017 Nov 10. Epub 2017 Nov 10.
    Department of Pathology, Dermatopathology Service, Memorial Sloan Kettering Cancer Center, New York, New York. Electronic address:
    Background: Immunodeficiency (ID) correlates with worse outcomes and decreased immune checkpoint molecule expression in melanoma. The impact of ID in mycosis fungoides (MF) is unknown.

    Objective: Our goal was to evaluate the impact of ID in MF. Read More

    Role of dysregulated cytokine signaling and bacterial triggers in the pathogenesis of Cutaneous T Cell Lymphoma.
    J Invest Dermatol 2017 Nov 8. Epub 2017 Nov 8.
    Department of Pathology, NYU School of Medicine, New York, NY 10016; Laura and Isaac Perlmutter Cancer Institute, NYU School of Medicine; New York, NY 10016. Electronic address:
    Cutaneous T cell lymphoma is a heterogeneous group of lymphomas characterized by the accumulation of malignant T cells in the skin. The molecular and cellular etiology of this malignancy remains enigmatic and what role antigenic stimulation plays in the initiation and/or progression of the disease remains to be elucidated. Deep sequencing of the tumor genome revealed a highly heterogeneous landscape of genetic perturbations and transcriptome analysis of transformed T cells further highlighted the heterogeneity of this disease. Read More

    Mycosis fungoides - A cutaneous lymphoproliferative disorder in a patient treated with fingolimod for multiple sclerosis.
    J Clin Neurosci 2017 Nov 3. Epub 2017 Nov 3.
    Department of Neurology, Barzilai University Medical Center, Ashkelon, Israel; Faculty of Health Sciences, Ben Gurion University of the Negev, Beer-Sheva, Israel.
    Fingolimod was the first oral disease-modifying drug approved for the treatment of relapsing-remitting multiple sclerosis (MS). It has previously been associated with rare cases of lymphoma. Here we describe the first case of mycosis fungoides - a cutaneous lymphoproliferative disorder, in an MS patient treated with fingolimod. Read More

    Standardization of regimens in Narrow-band UVB and PUVA in early stage Mycosis Fungoides: position paper from the Italian Task Force for Cutaneous Lymphomas.
    J Eur Acad Dermatol Venereol 2017 Nov 4. Epub 2017 Nov 4.
    Dermatology Unit Department of Surgery and Translational Medicine, University of Florence Medical School, Italy.
    UV- based (PUVA and Narrow Band UVB) phototherapy is broadly and commonly used in the treatment of Cutaneous T-cell Lymphomas (CTCL), yet unfortunately the evidence for the efficacy of these treatments is based only on cases series or prospective but non-randomized studies. Therefore, no internationally approved guidelines exists and no standardization of schedules have been proposed. Recently, Consensus guidelines have been published by the United States Cutaneous Lymphoma Consortium. Read More

    Hodgkin's lymphoma arising in a case of mycosis fungoides: An unusual association.
    Indian J Dermatol Venereol Leprol 2017 Nov 3. Epub 2017 Nov 3.
    Department of Pathology, Vardhman Mahavir Medical College, Safdarjung Hospital, New Delhi, India.
    Mycosis fungoides is a cutaneous T-cell lymphoma with a high risk for developing secondary malignancies, especially B-cell lymphoproliferative disorders. About 40 cases of Hodgkin's lymphoma associated with mycosis fungoides have been reported in literature till date. We report a case of a 35-year-old gentleman who presented with intensely itchy reddish lesions all over the body. Read More

    Folliculotropic mycosis fungoides presenting with a solitary lesion: clinicopathological features and long-term follow-up data in a series of nine cases.
    J Cutan Pathol 2017 Oct 31. Epub 2017 Oct 31.
    Departments of Dermatology, Leiden University Medical Center, The Netherlands.
    Folliculotropic mycosis fungoides (FMF) is a rare but distinct variant of mycosis fungoides (MF), histologically characterized by the presence of folliculotropic infiltrates, often with sparing of the epidermis, and clinically by the preferential involvement of the head and neck region.(1). Read More

    Thinking about CNS metastasis in cutaneous lymphoma: Analysis of existing data.
    Leuk Res Rep 2017 16;8:14-18. Epub 2017 Oct 16.
    Department of Dermatology, UT Southwestern Medical Center, 5323 Harry Hines Blvd., MSC 9069, Dallas, TX 75390-9069, USA.
    To determine some of the key clinical features that help prompt clinicians to pursue additional work-up for evaluation of CNS involvement of MF, we conducted a systematic review to better define characteristics, treatments, outcomes, and mortality in these patients. Our analyses indicated that neurologic surveillance after the diagnosis of MF is crucial. Review of systems should include change in mentation, vestibular, and ocular symptoms. Read More

    Regional incidences of adult T-cell leukemia/lymphoma with cutaneous involvement in Japan.
    J Dermatol 2017 Oct 25. Epub 2017 Oct 25.
    Departments of Dermatology, Okayama University Graduate School of Medicine, Dentistry and Pharmaceutical Sciences, Okayama, Japan.
    Between 2008 and 2015, 462 newly-diagnosed adult T-cell leukemia/lymphoma (ATLL) patients with cutaneous involvement were found from the nationwide registry for Japanese patients with cutaneous lymphoma, of which 391 were selected for the study. They ranged in age from 28 to 93 years (median, 69 years), and included 215 men and 176 women (male : female ratio = 1.2). Read More

    Granulomatous slack skin syndrome: Report of a unique case.
    Indian J Dermatol Venereol Leprol 2017 Aug 28. Epub 2017 Aug 28.
    Department of Dermatology, Madras Medical College and Rajiv Gandhi Government General Hospital, Chennai, Tamil Nadu, India.
    Granulomatous slack skin syndrome is a rare variant of cutaneous T-cell lymphoma (mycosis fungoides). It is characterized clinically by redundant skin folds, which show a predilection towards flexural areas such as the axilla and the groin. Histologically, it shows a granulomatous T-cell infiltrate and loss of elastic tissue. Read More

    Aprepitant for the Treatment of Chronic Refractory Pruritus.
    Biomed Res Int 2017 19;2017:4790810. Epub 2017 Sep 19.
    Department of Dermatology, Johns Hopkins University School of Medicine, Baltimore, MD, USA.
    Chronic pruritus is a difficult condition to treat and is associated with several comorbidities, including insomnia, depression, and decreased quality of life. Treatment for chronic itch includes corticosteroids, antihistamines, and systemic therapies such as naltrexone, gabapentin, UV light therapy, and immunomodulatory treatments, including azathioprine, methotrexate, and cellcept. However, some patients still remain refractory to conventional therapy. Read More

    Plasma miR-155, miR-203, and miR-205 are Biomarkers for Monitoring of Primary Cutaneous T-Cell Lymphomas.
    Int J Mol Sci 2017 Oct 15;18(10). Epub 2017 Oct 15.
    BIOCEV, First Faculty of Medicine, Charles University, 25250 Vestec, Czech Republic.
    Primary cutaneous T-cell lymphomas (CTCL) affect the skin and tend to transform and spread. CTCL involves primarily the Mycosis fungoides (MF) and more aggressive Sezary syndrome (SS). Oncogenic microRNAs (miRs) are stable epigenetic inhibitors often deregulated in the tumour and detectable as biomarkers in non-cellular fractions of peripheral blood. Read More

    Pachyderma in Primary Cutaneous NK and T-Cell Lymphoma and Leukemia Cutis.
    Case Rep Dermatol 2017 Sep-Dec;9(3):151-157. Epub 2017 Sep 11.
    Department of Dermatology, Liège University Hospital, Liège, Belgium.
    Background: Pachyderma is defined as severely thickened skin with deep folds and is occasionally observed with primary cutaneous NK and T-cell lymphoma (pCNKTCL), primary cutaneous B-cell lymphoma (pCBCL), and leukemia cutis (LC).

    Aim: To describe the clinical, histological, and therapeutic particularities of a series of pCNKTCL, pCBCL, and LC patients with pachyderma.

    Results: In a series of pCNKTCL (n = 70), pCBCL (n = 12), and LC (n = 2) patients followed up during 9 years, 6 cases of pachyderma were observed. Read More

    Differential expression of CCR4 in primary cutaneous gamma/delta (γ⁄δ) T cell lymphomas and mycosis fungoides: Significance for diagnosis and therapy.
    J Dermatol Sci 2017 Sep 1. Epub 2017 Sep 1.
    Department of Pathology, Section of Dermatopathology, The University of Texas MD Anderson Cancer Center, Houston, TX, United States; Department of Dermatology, The University of Texas MD Anderson Cancer Center, Houston, TX, United States. Electronic address:

    Clinical Insights and Emerging Strategies in Managing Cutaneous T-Cell Lymphoma.
    J Drugs Dermatol 2017 May;16(5):405-412

    Mycosis Fungoides and Sézary Syndrome, the two most common types of Cutaneous T-Cell Lymphoma (CTCL), present many management challenges for dermatologists. Here, we provide a comprehensive review of up-to-date literature, guidelines, and expert clinical insights. We highlight the updates in the World Health Organization Classification of Cutaneous Lymphomas; we summarize the epidemiology, including a recently observed stabilization of increasing incidence of CTCL in the past decade and increased incidence in males, blacks, and veterans; we also provide the most recent updates on prognostic factors for CTCL. Read More

    TruSeq-Based Gene Expression Analysis of Formalin-Fixed Paraffin-Embedded (FFPE) Cutaneous T-Cell Lymphoma Samples: Subgroup Analysis Results and Elucidation of Biases from FFPE Sample Processing on the TruSeq Platform.
    Front Med (Lausanne) 2017 22;4:153. Epub 2017 Sep 22.
    Division of Dermatology, McGill University Health Centre, Montreal, QC, Canada.
    Cutaneous T-cell lymphomas (CTCLs) are a heterogeneous group of malignancies with courses ranging from indolent to potentially lethal. We recently studied in a 157 patient cohort gene expression profiles generated by the TruSeq targeted RNA gene expression sequencing. We observed that the sequencing library quality and depth from formalin-fixed paraffin-embedded (FFPE) skin samples were significantly lower when biopsies were obtained prior to 2009. Read More

    First-line treatment in lymphomatoid papulosis: a retrospective multicentre study.
    Clin Exp Dermatol 2017 Oct 10. Epub 2017 Oct 10.
    Department of Dermatology, Hospital Clínico, University of Barcelona, IDIBAPS, Barcelona, Spain.
    Background: Data regarding response to treatment in lymphomatoid papulosis (LyP) are scarce.

    Aim: To assess the daily clinical practice approach to LyP and the response to first-line treatments.

    Methods: This was a retrospective study enrolling 252 patients with LyP. Read More

    Vitamin D and the Skin: An Update for Dermatologists.
    Am J Clin Dermatol 2017 Oct 9. Epub 2017 Oct 9.
    Department of Dermatology, Hôpital Henri Mondor, 51 Avenue du Maréchal de Lattre de Tassigny, 94010, Créteil, France.
    Vitamin D plays a key role in skeletal and cardiovascular disorders, cancers, central nervous system diseases, reproductive diseases, infections, and autoimmune and dermatological disorders. The two main sources of vitamin D are sun exposure and oral intake, including vitamin D supplementation and dietary intake. Multiple factors are linked to vitamin D status, such as Fitzpatrick skin type, sex, body mass index, physical activity, alcohol intake, and vitamin D receptor polymorphisms. Read More

    Hoarseness as a presentation of mycosis fungoides infiltrating the larynx.
    BMJ Case Rep 2017 Oct 9;2017. Epub 2017 Oct 9.
    Division of Dermatology, Washington University School of Medicine, St Louis, Missouri, USA.
    Laryngeal involvement is a rare manifestation of mycosis fungoides (MF), with only nine reported cases of cutaneous T cell lymphoma with laryngeal or vocal cord involvement. Herein, we report the case of a patient with a 7-year history of MF who presented to the emergency department with hoarseness, throat tightness and cough, as well as erythroderma and skin tumours. Laryngoscopy and CT imaging were concerning for lymphomatous involvement of the left false vocal cord. Read More

    Expression of FK506-binding protein 51 (FKBP51) in Mycosis fungoides.
    J Eur Acad Dermatol Venereol 2017 Oct 4. Epub 2017 Oct 4.
    Pathology Section, Department of Advanced Biomedical Sciences, University of Naples Federico II, Naples, Italy.
    Background: Mycosis fungoides (MF) is the major subtype of cutaneous T-cell lymphomas (CTCL). It usually has a prolonged indolent clinical course with a minority of cases acquiring a more aggressive biological profile and resistance to conventional therapies, partially attributed to the persistent activation of nuclear factor-kappa B (NF-κB) pathway. In the last decade, several papers suggested an important role for the FK506-binding protein 51 (FKBP51), an immunophilin initially cloned in lymphocytes, in the control of NF-κB pathway in different types of human malignancies. Read More

    Global patterns of care in advanced stage mycosis fungoides/Sezary syndrome: a multicenter retrospective follow-up study from the Cutaneous Lymphoma International Consortium.
    Ann Oncol 2017 Oct;28(10):2517-2525
    Department of Dermatology, Stanford University Medical Centre, USA.
    Background: Advanced-stage mycosis fungoides (MF)/Sézary syndrome (SS) patients are weighted by an unfavorable prognosis and share an unmet clinical need of effective treatments. International guidelines are available detailing treatment options for the different stages but without recommending treatments in any particular order due to lack of comparative trials. The aims of this second CLIC study were to retrospectively analyze the pattern of care worldwide for advanced-stage MF/SS patients, the distribution of treatments according to geographical areas (USA versus non-USA), and whether the heterogeneity of approaches has potential impact on survival. Read More

    Immunohistopathological Study of c-FLIP Protein in Mycosis Fungoides
    Asian Pac J Cancer Prev 2017 09 27;18(9):2493-2499. Epub 2017 Sep 27.
    Lecturer of Dermatology and Venereology, Faculty of medicine, Tanta University, 31111, Tanta, Egypt. Email:
    Background: Mycosis fungoides (MF) is the commonest variant of primary cutaneous T cell lymphoma with several clinicopathologic variants. Defective apoptotic mechanism may be important in the pathogenesis and progression of MF. c-FLIP protein is an important anti-apoptotic marker and chemotherapeutic resistant factor. Read More

    Pediatric mycosis fungoides: a study of the human leukocyte antigen system among Israeli Jewish patients.
    Arch Dermatol Res 2017 Dec 25;309(10):851-856. Epub 2017 Sep 25.
    Department of Dermatology, Rabin Medical Center, Beilinson Hospital, 4941492, Petach Tikva, Israel.
    Pediatric mycosis fungoides (MF) is a rare disease characterized by over-representation of atypical clinical variants, with a different prognosis from adult MF. Several human leukocyte antigen (HLA) alleles have been associated with MF in certain adult populations, including Israeli Jews. However, HLA data on pediatric MF as a group are lacking. Read More

    Serum vascular endothelial growth factor A levels reflect itch severity in mycosis fungoides and Sézary syndrome.
    J Dermatol 2017 Sep 19. Epub 2017 Sep 19.
    Department of Dermatology, University of Tokyo Graduate School of Medicine, Tokyo, Japan.
    Angiogenesis is an important step to support progression of malignancies, including mycosis fungoides (MF) and Sézary syndrome (SS). Vascular endothelial growth factor (VEGF)-A, a key player in angiogenesis, is secreted by tumor cells of MF/SS and its expression levels in lesional skin correlated with disease severity. In this study, we examined serum VEGF-A levels in MF/SS patients. Read More

    Periostin in the pathogenesis of skin diseases.
    Cell Mol Life Sci 2017 Dec 15;74(23):4321-4328. Epub 2017 Sep 15.
    Department of Dermatology, Course of Integrated Medicine, Graduate School of Medicine, Osaka University, 2-2 Yamadaoka, Suita, Osaka, 5650871, Japan.
    Skin is an organ that is susceptible to damage by external injury, chronic inflammation, and autoimmunity. Tissue damage causes alterations in both the configuration and type of cells in lesional skin. This phenomenon, called tissue remodeling, is a universal biological response elicited by programmed cell death, inflammation, immune disorders, and tumorigenic, tumor proliferative, and cytoreductive activity. Read More

    Therapeutic Antibodies to KIR3DL2 and Other Target Antigens on Cutaneous T-Cell Lymphomas.
    Front Immunol 2017 30;8:1010. Epub 2017 Aug 30.
    INSERM U976, Hôpital Saint-Louis, Paris, France.
    KIR3DL2 is a member of the killer cell immunoglobulin-like receptor (KIR) family that was initially identified at the surface of natural killer (NK) cells. KIR3DL2, also known as CD158k, is expressed as a disulfide-linked homodimer. Each chain is composed of three immunoglobulin-like domains and a long cytoplasmic tail containing two immunoreceptor tyrosine-based inhibitory motifs. Read More

    Photodynamic therapy: an option in mycosis fungoides.
    Photodiagnosis Photodyn Ther 2017 Sep 7. Epub 2017 Sep 7.
    Dermatology Unit, Department of Specialised, Experimental and Diagnostic Medicine, University of Bologna, Bologna, Italy.
    Background: Photodynamic therapy (PDT) is a well-known and effective treatment for non-melanoma skin-cancer. Numerous studies have also shown its effectiveness in mycosis fungoides. The aim of the study was to analyse MF patients treated with PDT at the Dermatology Unit of Bologna University. Read More

    Alternate dosing regimens of brentuximab vedotin for CD30+ cutaneous T-cell lymphoma: reply from authors.
    Br J Dermatol 2017 Sep 10. Epub 2017 Sep 10.
    Department of Dermatology, Venerology, Allergology and Phlebology, Johannes Wesling Medical Centre, University Hospital of Ruhr-University, Bochum, Germany.
    We thank the authors Lewis, Kim, and Duvic, for their reaction to our article. The increasingly personalised medicine should also take into account individual tumour entities and their inter-individual pathways. Therefore, we can only welcome and sustain the comments. Read More

    Alternate dosing regimens of brentuximab vedotin for CD30+ cutaneous T-cell lymphoma.
    Br J Dermatol 2017 Sep 10. Epub 2017 Sep 10.
    Department of Dermatology, The University of Texas MD Anderson Cancer Center, Houston, TX, USA.
    Stranzenbach et al. propose alternate dosing regimens of brentuximab vedotin (BV) for CD30+ cutaneous T-cell lymphomas (CTCLs) such as mycosis fungoides (MF) and primary cutaneous anaplastic large cell lymphoma (pcALCL).(1) They emphasize that lower doses or less frequent dosing schedules for CTCL may be equally effective while limiting adverse events. Read More

    AN-7, a butyric acid prodrug, sensitizes cutaneous T-cell lymphoma cell lines to doxorubicin via inhibition of DNA double strand breaks repair.
    Invest New Drugs 2017 Sep 8. Epub 2017 Sep 8.
    Laboratory for Molecular Dermatology, Felsenstein Medical Research Center, Petach Tikva and Sackler Faculty of Medicine, Tel Aviv University, Tel Aviv, Israel.
    We previously found that the novel histone deacetylase inhibitor (HDACI) butyroyloxymethyl diethylphosphate (AN-7) had greater selectivity against cutaneous T-cell lymphoma (CTCL) than SAHA. AN-7 synergizes with doxorubicin (Dox), an anthracycline antibiotic that induces DNA breaks. This study aimed to elucidate the mechanism underlying the effect of AN-7 on Dox-induced double-strand DNA breaks (DSBs) in CTCL, MyLa and Hut78 cell lines. Read More

    Cutaneous T-cell lymphoma: 2017 update on diagnosis, risk-stratification, and management.
    Am J Hematol 2017 Oct;92(10):1085-1102
    Division of Hematology/Oncology, University of Michigan Comprehensive Cancer Center, Ann Arbor, Michigan, 48109-5948.
    Disease Overview: Cutaneous T-cell lymphomas are a heterogenous group of T-cell lymphoproliferative disorders involving the skin, the majority of which may be classified as Mycosis Fungoides (MF) or Sézary Syndrome (SS).

    Diagnosis: The diagnosis of MF or SS requires the integration of clinical and histopathologic data.

    Risk-adapted Therapy: TNMB (tumor, node, metastasis, blood) staging remains the most important prognostic factor in MF/SS and forms the basis for a "risk-adapted," multi-disciplinary approach to treatment. Read More

    Oral and maxillofacial non-Hodgkin lymphomas: Case report with review of literature.
    Medicine (Baltimore) 2017 Sep;96(35):e7890
    aDepartment of Head Neck Surgery, Hainan Cancer Hospital, Haikou, Hainan bDepartment of Oral and Maxillofacial Surgery, the First Affiliated Hospital of Nanchang University, Nanchang, Jiangxi, China.
    Rationale: Lymphomas take up about 14% of all head-neck malignancies, out of which 97% are non-Hodgkin lymphomas (NHL). The clinical courses, treatment responses, and prognoses of NHLs vary with different subtypes and anatomic sites. In the Chinese population (including the Taiwanese), head-neck NHLs are often seen with the tonsils, nasal cavity, nasal sinus, and the nasopharynx. Read More

    Phototherapy of mycosis fungoides.
    G Ital Dermatol Venereol 2017 Dec 28;152(6):597-606. Epub 2017 Jul 28.
    Department of Dermatology and Venereology, University Hospital of St. Pölten, Karl Landsteiner University of Health Sciences, Krems an der Donau, Austria -
    Mycosis fungoides (MF), the most common variant among cutaneous T cell lymphomas (CTCL), is characterized in its early stages by clonal proliferation of malignant T-cells in the skin manifesting as erythematous patches and plaques with a chronic course and progression to cutaneous tumors and extracutaneous organs in some patients. Skin directed therapies (SDT) are primarily used for effective palliation in early stage disease. Phototherapy with ultraviolet A radiation combined with 8-methoxypsoralen (PUVA) and with ultraviolet B radiation (UVB) has a longstanding history in the treatment of MF and are highly effective in inducing remissions. Read More

    The Results of Low-Dose Total Skin Electron Beam Radiation Therapy (TSEB) in Patients With Mycosis Fungoides From the UK Cutaneous Lymphoma Group.
    Int J Radiat Oncol Biol Phys 2017 Jun 9. Epub 2017 Jun 9.
    Guy's and St Thomas' NHS Foundation Trust, London, UK.
    Purpose: Total skin electron beam radiation therapy (TSEB) is a very effective treatment of mycosis fungoides. Following reports of similar durations of response to lower doses of TSEB, a low-dose schedule of TSEB was introduced in the United Kingdom.

    Methods And Materials: A protocol of 12 Gy in 8 fractions over a period of 2 weeks was agreed on by use of the Stanford University technique. Read More

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