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J Dtsch Dermatol Ges 2018 Dec 14. Epub 2018 Dec 14.

Dermatology Service, Department of Medicine, Memorial Sloan Kettering Cancer Center, and Weill Cornell Medicine, New York, NY, USA.

Cancer 2018 Dec 11. Epub 2018 Dec 11.

Department of Epidemiology, University of North Carolina at Chapel Hill, Chapel Hill, North Carolina.

Background: As the US population ages and non-Hodgkin lymphoma (NHL)-specific mortality declines, deaths from causes other than NHL will become increasingly important in treatment decision making for older patients with NHL. The objective of the current study was to describe how the 5-year cumulative incidence of NHL-specific and other-cause mortality varies by subtype, age, comorbidity level, and time since diagnosis in older patients.

Methods: Using the Surveillance, Epidemiology, and End Results cancer registry data linked to Medicare claims, patients aged ≥66 years were identified at the time of diagnosis with a first, primary NHL diagnosis from 2004 through 2013. Read More

Eur J Dermatol 2018 Dec 10. Epub 2018 Dec 10.

University of Tokyo Graduate School of Medicine, Department of Dermatology, Tokyo, Japan.

Progranulin (PGRN) is a multi-functional protein known to be involved in diverse biological processes, including tumourigenesis, anti-inflammation, and anti-infection. PGRN expression in sera or tissues is elevated in a variety of malignancies and is associated with poor prognosis. However, it remains to be determined whether PGRN is involved in Mycosis fungoides (MF). Read More

Clin Lymphoma Myeloma Leuk 2018 Nov 17. Epub 2018 Nov 17.

Roswell Park Comprehensive Cancer Center, Buffalo, NY. Electronic address:

Background: Although standard-dose total skin electron beam therapy (TSEBT) has been thought to provide the greatest clinical benefit for mycosis fungoides, recent studies have shown that low-dose TSEBT may also provide high rates of disease control.

Materials And Methods: A retrospective chart review was conducted for patients receiving TSEBT for mycosis fungoides at a single institution from 2009 to 2017. Patients were evaluated for overall survival, progression-free survival, and duration of clinical benefit. Read More

Chin Clin Oncol 2018 Nov 21. Epub 2018 Nov 21.

Lymphoma Service, Department of Medicine, Memorial Sloan Kettering Cancer and Weill Cornell Medical College, New York, NY, USA.

The vast majority of cutaneous T-cell lymphomas (CTCL) are encompassed by mycosis fungoides and CD30+ lymphoproliferative disorder (LPD), however rare distinct CTCLs have been defined. The current edition of the World Health Organization (WHO) includes 12 CTCL subtypes with discrete diagnosable clinical, histologic and phenotypic features. The rarest subtypes, i. Read More

Chin Clin Oncol 2018 Nov 28. Epub 2018 Nov 28.

Department of Dermatology, University Hospital Birmingham, Birmingham, UK.

Mycosis fungoides (MF) represents the majority of the primary cutaneous T-cell lymphomas (CTCL). Most have early stage MF with localised patches and plaques, which has a favourable survival outcome, but nearly a quarter progress to late stage with tumours, erythroderma, and systemic involvement. Management is based on stage directed treatment with early stage MF (IA-IIA) using skin directed therapies (SDTs), including topical corticosteroids (TCS), chlormethine or retinoids, phototherapy, and radiotherapy (localised or total skin electron beam therapy). Read More

Chin Clin Oncol 2018 Oct 19. Epub 2018 Oct 19.

Department of Medical Oncology, Sidney Kimmel Cancer Center, Thomas Jefferson University, Philadelphia, Pennsylvania, USA.

Mycosis fungoides and Sézary syndrome encompass over 70% of all cases of cutaneous T-cell lymphoma (CTCL). While early stage disease has excellent long-term survival rates, advanced stage disease (IIB-IV) carries a poor prognosis with a median 5-year overall survival rate of approximately 50%. Early stage and advanced stage disease have different treatment algorithms with systemic therapy being indicated upfront in the later. Read More

Chin Clin Oncol 2018 Nov 14. Epub 2018 Nov 14.

Department of Dermatology and Cutaneous Biology, Thomas Jefferson University, Philadelphia, PA, USA.

Mycosis fungoides (MF) is the most common type of cutaneous T-cell lymphoma within the general population. Low dose total skin electron beam therapy (TSEBT) and topical nitrogen mustard (Valchlor) are two treatment modalities that have been proven to be efficacious in the treatment of MF. While each have been studied independently in various clinical trials, the use of Valchlor as maintenance therapy after completion of low dose TSEBT is rarely implemented due to the lack of evidence in the literature. Read More

Chin Clin Oncol 2018 Oct 29. Epub 2018 Oct 29.

Department of Dermatology and Cutaneous Biology, Thomas Jefferson University Hospital, Philadelphia, PA, USA.

Chin Clin Oncol 2018 Sep 17. Epub 2018 Sep 17.

Department of Radiation Oncology, Thomas Jefferson University, Philadelphia, PA 19107, USA.

Cutaneous T-cell lymphoma is a rare group of malignancies characterized by the proliferation of CD4+ T-cells, of which mycosis fungoides (MF) is the predominant subtype. The neoplastic lymphocytes of MF are extremely radiosensitive and even low doses of radiation can produce excellent responses. As such, radiotherapy (RT) is considered to be the most efficacious single agent treatment option for MF. Read More

J Am Acad Dermatol 2018 Dec 3. Epub 2018 Dec 3.

Loyola Univ Medical Center Dermatology, 321 N La Grange Rd, La Grange Park, IL. Electronic address:

•Active cancers and inflammation increase the risk for venous thromboembolism. It is unknown whether this applies to mycosis fungoides and parapsoriasis.•Patients with mycosis fungoides and parapsoriasis have increased risk for venous thromboembolism. Read More

Int J Dermatol 2018 Dec 6. Epub 2018 Dec 6.

School of Medicine, Indiana University, Indianapolis, IN, USA.

Background: CD8 lymphomatoid papulosis is frequently indistinguishable histopathologically from primary cutaneous aggressive epidermotropic CD8 T-cell lymphoma except for the expression of CD30. However, absent or weak expression of CD30 has been rarely reported in cases of CD8 LyP.

Objective: We aim to study the clinical and pathologic features of cases of CD8 LyP with no or minimal expression of CD30. Read More

J Eur Acad Dermatol Venereol 2018 Dec 6. Epub 2018 Dec 6.

Dermatology Department, Cutaneous Lymphoma Clinic, National& Kapodestrian University of Athens, Medical School, "A. Sygros" Hospital for skin diseases, Athens, Greece.

Over the last decade major efforts have been made for the optimization of immune-directed therapies against cancer. Regarding cutaneous lymphomas (CTCLs), brentuximab (BV) has been recently approved by FDA and EMA for the treatment of primary cutaneous anaplastic large cell lymphoma as well as CD30-expressing mycosis fungoides, based on the ALCANZA trial favorable results. Concurrently, immune checkpoint inhibition has been shown to be of great value in the treatment of solid tumors and with promising results in a range of hematologic malignancies, however relevant data concerning CTCLs' treatment remain inconclusive. Read More

Case Rep Oncol 2018 Sep-Dec;11(3):721-728. Epub 2018 Nov 12.

Department of Radiation Oncology, The University of Texas MD Anderson Cancer Center, Houston, Texas, USA.

Background: Involvement of the central nervous system (CNS) by mycosis fungoides (MF) is rare; however, it portends a poor prognosis. While aggressive multimodality therapy may improve outcomes, the role of radiation therapy (RT) is not well defined.

Objectives: We sought to explore the efficacy of RT in the management of CNS involvement by MF. Read More

Cell Death Dis 2018 Dec 5;9(12):1178. Epub 2018 Dec 5.

Istituto Dermopatico dell'Immacolata, IDI-IRCCS, Rome, Italy.

Cutaneous T-cell lymphoma is a group of incurable extranodal non-Hodgkin lymphomas that develop from the skin-homing CD4 T cell. Mycosis fungoides and Sézary syndrome are the most common histological subtypes. Although next-generation sequencing data provided significant advances in the comprehension of the genetic basis of this lymphoma, there is not uniform consensus on the identity and prevalence of putative driver genes for this heterogeneous group of tumors. Read More

Br J Dermatol 2018 Dec;179(6):1243-1244

Centre for Rare Diseases, University Hospital Birmingham, Birmingham, U.K.

Hematol Oncol Clin North Am 2019 Feb;33(1):103-120

Department of Dermatology, Brigham and Women's Hospital, Dana Farber Cancer Institute, Harvard Medical School, 450 Brookline Avenue, Boston, MA 02115, USA.

Cutaneous T-cell lymphomas are a heterogeneous collection of non-Hodgkin lymphomas that arise from skin-tropic memory T lymphocytes. Among them, mycosis fungoides (MF) and Sézary syndrome (SS) are the most common malignancies. Diagnosis requires the combination of clinical, pathologic, and molecular features. Read More

An Bras Dermatol 2018 Nov/Dec;93(6):913-915

Dermatology Department, Hospital Italiano de Buenos Aires, Buenos Aires, Argentina.

The growth factor receptor c-kit (CD117) is expressed in immature T-cells and in some advanced forms of mycosis fungoides. c-kit gene mutation results in unrestricted neoplastic proliferation. We aimed to detect by PCR the most frequent exon mutations in seventeen plaque-stage MF patients, in their perilesional skin and in healthy skin donors. Read More

Dermatol Pract Concept 2018 Oct 31;8(4):328-329. Epub 2018 Oct 31.

Dermatology Unit, University of Campania, Nuovo Policlinico, Naples, Italy.

Pathol Res Pract 2018 Dec 21;214(12):2106-2109. Epub 2018 Oct 21.

Department of Pathology, Chi-Mei Medical Center, Tainan, Taiwan; Department of Pathology, School of Medicine, College of Medicine, National Taiwan University, Taipei, Taiwan; Department of Pathology, School of Medicine, College of Medicine, Taipei Medical University, Taipei, Taiwan. Electronic address:

Background: Primary cutaneous peripheral T-cell lymphomas (PC-PTCLs) are classified into mycosis fungoides (MF) and other rare specific types; and those do not fit into any specific entities are designated as PTCL, not otherwise specified (NOS), an aggressive neoplasm. Monomorphic epitheliotropic intestinal T-cell lymphoma (MEITL) is an aggressive primary intestinal T-cell lymphoma with enteropathy in the non-neoplastic mucosa. We report a rare case of PC-PTCL-NOS with a late relapse solely in the ileum after complete remission. Read More

J Eur Acad Dermatol Venereol 2018 Nov 25. Epub 2018 Nov 25.

Department of dermatology, La Rabta Hospital. Tunis, Tunisia.

We have read with great interest a case report published by Slawinka et al describing trichoscopic spectrum of folliculotropic mycosis fungoides (FMF) [1]. Different trichoscopic aspects were reported by authors as the presence of milky white globules, yellow dots, short hair with split or triangle-shaped end, broken hair and pigtail appearance hair. This article is protected by copyright. Read More

Histopathology 2018 Nov 20. Epub 2018 Nov 20.

Centre Hospitalier Universitaire (CHU) Clermont-Ferrand, Dermatology Department, Centre Hospitalier Estaing, 1 place Lucie Aubrac, 63100, Clermont-Ferrand, France.

Large-cell transformation in mycosis fungoides (MF) is usually encountered in tumors and is associated with prognosis worsening. It is defined by the onset of more than 25% of lymphocytes, usually expressing CD30, exceeding 4 times the size of normal lymphocytes, either diffuse or organized in sheets in the dermal infiltrate. Recently, an unusual biphasic pathologic pattern was reported in lymphomatoid papulosis (LyP) and primary cutaneous anaplastic large cell lymphoma (ALCL) which was constantly associated with DUSP22-IRF4 gene rearrangement . Read More

Br J Dermatol 2018 Nov 15. Epub 2018 Nov 15.

Laboratory for Molecular Dermatology, Felsenstein Medical Research Center, Petach Tikva, and Sackler Faculty of Medicine, Tel Aviv University, Tel Aviv, Israel.

Background: The molecular basis of unilesional mycosis fungoides (MF), characterized by a solitary lesion which is clinicopathologically indistinguishable from multifocal patch/plaque MF (early MF), is unknown.

Objectives: To investigate the microRNA (miR) profile in unilesional MF distinguishing it from early MF.

Methods: Biopsy samples of unilesional MF and early MF were evaluated with the Affymetrix microRNA array, with further comparison to inflammatory dermatosis, using quantitative polymerase chain reaction. Read More

J Cutan Pathol 2018 Nov 14. Epub 2018 Nov 14.

Universidade de Lisboa, Faculdade de Medicina, Clínica Universitária de Dermatologia de Lisboa, Portugal.

Am J Clin Dermatol 2018 Nov 15. Epub 2018 Nov 15.

University of Texas MD Anderson Cancer Center, 1515 Holcombe Blvd, Unit 1452, Houston, TX, 77030-4009, USA.

Cutaneous T-cell lymphomas (CTCLs) are a group of non-Hodgkin's lymphomas that present in the skin. In early-stage disease, the course is generally chronic and indolent; however, in advanced stages of disease, therapies rarely provide long-lasting responses, and the only potential curative therapy is allogeneic hematopoietic stem-cell transplantation. This has led to the search for novel targeted therapies to better treat more advanced stages of CTCLs that cannot be controlled by typical treatment regimens. Read More

Leuk Lymphoma 2018 Nov 14:1-4. Epub 2018 Nov 14.

a Department of Medicine, Division of Hematology, Miller School of Medicine , University of Miami , Miami , FL , USA.

JAMA Dermatol 2018 Dec;154(12):1424-1431

Dermatology Department, Hospital Universitari de Bellvitge, IDIBELL, Barcelona, Spain.

Importance: Hypertriglyceridemia is the most frequent and limiting adverse effect of bexarotene therapy in cutaneous T-cell lymphoma (CTCL). Despite standard prophylactic measures, there is a wide variability in the severity of this complication, which could be associated with both genetic and environmental factors.

Objectives: To analyze the association between genetic polymorphisms of apolipoprotein genes APOA5, APOC3, and APOE and the severity of hypertriglyceridemia during bexarotene therapy and to optimize patient selection for bexarotene therapy based on adverse effect profile. Read More

J Cutan Pathol 2018 Nov 8. Epub 2018 Nov 8.

Department of Dermatology and Allergology, Klinikum Bremen-Mitte, Bremen, Germany.

A 42-year-old Caucasian man suffered from disseminated plaques and ulcerated nodules for 6 weeks. He had weight loss and generalized lymphadenopathy. Underlying diseases were not known up till then. Read More

Arch Pathol Lab Med 2018 Nov;142(11):1352-1357

From the Department of Pathology, University of Iowa Health Care, Iowa City (Dr Chen); and the Departments of Pathology (Drs Boyer and Hristov) and Dermatology (Dr Hristov), University of Michigan Medical Center, Ann Arbor.

Composite lymphomas have been defined as 2 distinct subtypes of lymphoma occurring at a single anatomic site. Composite lymphomas limited to the skin are a rare occurrence and pose a unique challenge. Many reported cases within the skin are combined B-cell and T-cell lymphomas, typically mycosis fungoides and a low-grade B-cell lymphoma. Read More

Acta Dermatovenerol Croat 2018 Oct;26(3):264-266

Jaka Radoš, MD, University Hospital Centre Zagreb Department of Dermatology and Venereology School of Medicine University of Zagreb Šalata 4, 10000 Zagreb , Croatia;

Dear Editor,We present the case of a 40-year old male patient with lymphomatoid papulosis of a waxing and waning course on whom three biopsies were performed during a 14-year period with no change in histopathological or immunophenotypical characteristics. Lymphomatoid papulosis (LP) is a chronic, recurrent, self-healing papulonodular skin eruption with the histopathologic features of a cutaneous T-cell lymphoma but an often benign and indolent clinical course (1). It is designated as a primary, cutaneous, CD30+ lymphoproliferative disorder. Read More

J Cutan Pathol 2018 Nov 1. Epub 2018 Nov 1.

Department G.F. Ingrassia, Section of Anatomic Pathology, University of Catania, Catania, Italy.

Turk J Med Sci 2018 Oct 31;48(5):1013-1023. Epub 2018 Oct 31.

Background/aim: Lymphoma cases diagnosed at one of the largest tertiary reference centers in Turkey were reviewed and findings were compared to those reported from other regions of the world. Materials and methods: Lymphomas diagnosed between 2000 and 2017 in the pathology laboratory of Hacettepe University were identified. A total of 4239 cases were analyzed. Read More

J Dermatol 2018 Oct 31. Epub 2018 Oct 31.

Department of Dermatology, University of Tokyo Graduate School of Medicine, Tokyo, Japan.

Sézary syndrome (SS) is defined by erythroderma and circulating atypical T cells, with or without lymphadenopathy. Recently, Thompson et al. identified a distinct population of SS patients with an atypical presentation: a high blood tumor burden of Sézary cells fulfilling criteria for SS but without fulfilling the criteria for erythroderma at the diagnosis. Read More

Eur J Dermatol 2018 Oct;28(5):621-627

Department of Dermatology, University of Tokyo Graduate School of Medicine, Tokyo, Japan.

Background: High mobility group box-1 (HMGB1) is a ubiquitously expressed non-histone nuclear protein which acts as a danger signal when released from cells. HMGB1, which is associated with inflammation, angiogenesis, and T helper (Th)2 polarization, contributes to the development of various inflammatory diseases and malignancies. However, it remains to be determined whether HMGB1 is involved in cutaneous T-cell lymphoma (CTCL). Read More

Pan Afr Med J 2018;30:138. Epub 2018 Jun 18.

Department of Dermatology, Ibn Sina University Hospital, Rabat, Morocco.

Am J Dermatopathol 2018 Oct 24. Epub 2018 Oct 24.

Research Unit Dermatopathology, Department of Dermatology, Medical University of Graz, Graz, Austria.

Perieccrine inflammation may be observed in several different dermatoses, but true permeation of the secretory coil by lymphocytes (lymphocytic syringotropism) is a rather uncommon finding, usually observed in mycosis fungoides (MF-syringotropic MF). Rare cases of syringotropic lichen striatus and lymphocytic autoimmune hidradenitis showing a similar pattern have been described as well. We describe an exceptional case of lichen planus (LP) characterized by marked lymphocytic syringotropism with focal hyperplasia of the eccrine epithelium. Read More

J Am Acad Dermatol 2018 Oct 23. Epub 2018 Oct 23.

Department of Pathology and Laboratory Medicine, Perelman School of Medicine, University of Pennsylvania.

J Infect Dis 2018 Oct 23. Epub 2018 Oct 23.

Department of Microbiology and Infection, Kochi Medical School, Kochi University, Kochi, Japan.

Background: Human skin microorganisms have been associated with various skin diseases. However, most studies have focused on bacterial communities and little is known about normally resident skin viruses such as the Polyomaviridae and their association with cutaneous disorders.

Methods: We investigated the infection levels of Merkel cell polyomavirus (MCPyV), human polyomavirus 6 (HPyV6) and human polyomavirus 7 (HPyV7), using triplet skin swabs collected from lesional and nonlesional skins of 86 Japanese patients with inflammatory skin diseases and mycosis fungoides, and from 149 healthy control individuals. Read More

Pathology 2018 Dec 20;50(7):718-724. Epub 2018 Oct 20.

Department of Pathology, Chi-Mei Medical Center, Tainan, Taiwan; Department of Pathology, School of Medicine, Taipei Medical University and National Taiwan University, Taipei, Taiwan. Electronic address:

Mycosis fungoides (MF) is an indolent cutaneous T-cell lymphoma and may transform into large cell lymphoma in the disease course. The incidence of MF in Taiwan is lower as compared to that in the West. In this study we aimed to characterise the clinicopathological, immunohistochemical, and genetic features of transformed MF (t-MF) in Taiwan. Read More

Cytometry B Clin Cytom 2018 Oct 16. Epub 2018 Oct 16.

Department of Hematopathology and Laboratory Medicine, H. Lee Moffitt Cancer Center, Tampa, Florida.

Background: Mycosis fungoides (MF) and Sézary Syndrome (SS) are clinically distinct cutaneous T-cell lymphomas with strikingly similar morphologic and phenotypic features. Prior studies have suggested phenotypic differences based on markers of antigen experience, suggesting a different cell of origin.

Methods: Seventy-nine involved peripheral blood or bone marrow samples from 33 patients with SS and 19 patients with MF were studied by 10-color flow cytometry, including CD62L, CD45RA, CCR4, and PD-1. Read More

J Cutan Pathol 2018 Oct 16. Epub 2018 Oct 16.

Department of Dermatology, Palo Alto Medical Foundation, Palo Alto, California.

Introduction: Mycosis fungoides (MF) with large cell transformation (LCT) is an advanced stage of cutaneous lymphoma with a poor prognosis. Identification of LCT is critical and especially challenging when the number of large abnormal lymphocytes is near but below 25%. We propose that Ki-67 and p53 may be useful in making this diagnosis. Read More

Photochem Photobiol Sci 2018 Dec;17(12):1904-1912

Department of Dermatology and Venereology, Karl Landsteiner University of Health Sciences, University Hospital of St. Pölten, Austria.

Cutaneous T-cell lymphomas (CTCL) are a heterogenous group of non-Hodgkin lymphomas arising in the skin. Mycosis fungoides (MF), the most common variant, is characterised by clonal proliferation of skin residing malignant T-cells. Initially appearing with erythematous patches and plaques it follows a chronic course with progression to cutaneous tumours and extracutaneous involvement in some patients. Read More

J Cutan Med Surg 2018 Nov/Dec;22(6):646

1 Department of Dermatology, Texas Tech University Health Sciences Center, Lubbock, TX, USA.

Pediatr Dermatol 2018 Oct 15. Epub 2018 Oct 15.

Department of Pathology & Laboratory Medicine, Weill Cornell Medicine, New York, New York.

Acral pseudolymphomatous angiokeratoma of children (APACHE) and unilesional mycosis fungoides (MF) are two rare dermatoses in the pediatric population which may have overlapping clinical and histopathologic features, making differentiation between these two diagnoses difficult. We present two similar cases of a solitary plaque on the thigh of a child, one representing APACHE and the other representing unilesional MF with granulomatous features, and we provide a brief overview of the clinical and histopathologic features of APACHE and unilesional MF. Read More

J Eur Acad Dermatol Venereol 2018 Oct;32(10):1626

Department of Dermatology, Medical University of Vienna, Vienna, Austria.

Leuk Lymphoma 2018 Oct 10:1-4. Epub 2018 Oct 10.

a MD Anderson Cancer Center , Houston , TX , USA.

Br J Dermatol 2018 Oct 9. Epub 2018 Oct 9.

Department of dermatology, Hôpital Saint-Louis, Paris, AP-HP, Inserm U976Paris 7 University.

Treatment of cutaneous T-cell lymphoma is based on skin-directed therapies for early stage disease and systemic therapies for advanced stage disease. Romidepsin (Istodax©) is a histone deacetylase inhibitor approved by the FDA, after two phase II pivotal studies for the treatment of Mycosis Fungoides (MF) and Sézary Syndrome (SS) after at least one prior line of systemic therapy . In France, romidepsin is only available on Authorization for Temporary Use. Read More

Int J Dermatol 2018 Oct 7. Epub 2018 Oct 7.

Academia Nacional de Medicina, Ciudad de Buenos Aires, Argentina.

Background: The aim of this study was to determine the relative frequency of primary cutaneous lymphoma (PCL) in Argentina according to the new World Health Organization (WHO)-European Organization for the Research and Treatment of Cancer (EORTC) classification system.

Methods: A total of 416 patients from 21 dermatology services were included during a 5-year period (2010-2015); these patients were classified using WHO-EORTC criteria.

Results: There were 231 (55. Read More

Clin Exp Dermatol 2018 Oct 7. Epub 2018 Oct 7.

Department of Dermatology, Coimbra Hospital and University Centre, Coimbra, Portugal.