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    Two faces of gamma-delta mycosis fungoides: before and after renal transplantation.
    BMJ Case Rep 2017 Feb 22;2017. Epub 2017 Feb 22.
    Department of Dermatology and Venereology, Karl Landsteiner University of Health Sciences, Sankt Pölten, Austria.
    We describe a patient with a 30-year history of mycosis fungoides (MF) and renal transplantation performed 3 years before he presented with an ulcerated tumour in the lumbosacral area. Biopsy revealed a lymphatic infiltrate of medium-sized, pleomorphic T cells expressing the gamma-delta T-cell receptor. Radiological staging and bone marrow biopsy revealed no extracutaneous involvement. Read More

    CD30-positive cutaneous lymphoma: report of four cases with an emphasis on clinicopathological correlations.
    An Bras Dermatol 2017 Jan-Feb;92(1):86-91
    Hospital Federal de Bonsucesso - Bonsucesso (RJ), Brazil.
    The classification of cutaneous lymphomas is multidisciplinary and requires the correlation between clinical, histopathological, immunohistochemical, and molecular diagnostic elements. In this article, we present four different cases of CD30-positive T-cell lymphoma with cutaneous manifestations. We compare cases with definitive diagnosis of papulosis lymphomatoid type C, primary cutaneous anaplastic large T-cell lymphoma, systemic anaplastic large T-cell lymphoma with secondary skin involvement, and mycosis fungoides with large cell transformation, highlighting the importance of clinicopathological correlation to classify these cases. Read More

    Secondary Cutaneous Amyloidosis in a Patient with Mycosis Fungoides.
    Ann Dermatol 2017 Feb 3;29(1):79-82. Epub 2017 Feb 3.
    Department of Dermatology, Dankook University Medical College, Cheonan, Korea.
    Secondary cutaneous amyloidosis refers to clinically unapparent amyloid deposits within the skin in association with a pre-existing skin condition or skin tumors, such as basal cell carcinoma, porokeratosis, solar elastosis, Bowen's disease, and mycosis fungoides. A 70-year-old woman presented with a 6-month history of asymptomatic multiple yellowish plaques on both legs. She had been diagnosed with mycosis fungoides 7 years ago and was treated with psoralen and ultraviolet A radiation (PUVA) therapy, narrow-band ultraviolet B (UVB) therapy, and acitretin for 5 years. Read More

    Is CCNU (lomustine) valuable for treatment of cutaneous epitheliotropic lymphoma in dogs? A critically appraised topic.
    BMC Vet Res 2017 Feb 21;13(1):61. Epub 2017 Feb 21.
    Department of Clinical Sciences, College of Veterinary Medicine, North Carolina State University, Raleigh, NC, USA.
    Background: CCNU and other treatment protocols are commonly offered to owners for the treatment of dogs diagnosed with cutaneous (epitheliotropic) T-cell lymphoma (CTCL). Chemotherapy protocols provide variable benefits; they have different side-effects, and they typically require monitoring to detect drug toxicity at a non-negligible cost to the owner. At this time, even though CCNU is most often recommended to treat dogs with CTCL, there is no clear consensus on the benefit of this drug. Read More

    Primary cutaneous non-Hodgkin lymphoma: results of a retrospective analysis in the light of the recent ILROG guidelines.
    Tumori 2017 Feb 14. Epub 2017 Feb 14.
    Radiation Oncology Department, Azienda Ospedaliera Spedali Civili di Brescia and Brescia University, Brescia - Italy.
    Purpose: To analyze clinical outcome, local response, survival and toxicity in patients with primary cutaneous lymphoma (PCL) treated with radiotherapy.

    Methods: From 1995 to 2014, 112 patients were treated. B-cell lymphomas (CBCLs; n = 86) and T-cell lymphomas (CTCLs; n = 23) were analyzed separately. Read More

    Lymphoma of the Eyelid - An International Multicenter Retrospective Study.
    Am J Ophthalmol 2017 Feb 13. Epub 2017 Feb 13.
    Department of Pathology, Rigshospitalet, University of Copenhagen, Denmark; Department of Ophthalmology, Rigshospitalet-Glostrup, University of Copenhagen, Denmark. Electronic address:
    Purpose: To document subtype-specific clinical features of lymphoma of the eyelid, and their effect on patient outcome.

    Design: Retrospective observational case series.

    Methods: Patient data were collected from 7 international eye cancer centers from January 1st 1980 through December 31st 2015. Read More

    High Expression of Fas/CD95 on CD4+ Circulating T-cells: An Exclusion Criterion in the Diagnosis of Mycosis Fungoides?
    Acta Derm Venereol 2017 Feb 16. Epub 2017 Feb 16.
    Department of Dermatology, University of Montpellier, Hôpital Saint-Eloi, 80 avenue Augustin Fliche, FR-34295 Montpellier, France.
    The aim of this 10-year monocentric prospective study was to determine a cut-off value of Fas/CD95 expression by peripheral blood CD4+ T lymphocytes in discriminating patients with mycosis fungoides from controls with cutaneous benign lymphocytic conditions. CD95 expression in peripheral blood CD4+ T lymphocytes was measured using flow cytometry in 330 patients referred for diagnosis: 104 with mycosis fungoides and 226 with eczema, psoriasis, drug reaction, etc. The sensitivity and specificity of different thresholds of CD95 expression were calculated regarding the final diagnosis of patients with mycosis fungoides or controls. Read More

    Evaluation of O6-Benzylguanine-Potentiated Topical Carmustine for Mycosis Fungoides: A Phase 1-2 Clinical Trial.
    JAMA Dermatol 2017 Feb 15. Epub 2017 Feb 15.
    Department of Dermatology, University Hospitals Cleveland Medical Center, Cleveland, Ohio5Case Comprehensive Cancer Center, Case Western Reserve University, Cleveland, Ohio.
    Importance: In a phase 1 trial, single-dose O6-benzylguanine with topical carmustine for patients with early stage (stage IA through stage IIA) cutaneous T-cell lymphoma, mycosis fungoides (MF) type, resulted in clinical responses proportional to inhibition of O6-alkylguanine DNA alkyltransferase activity, but a maximum tolerated dose (MTD) was not reached.

    Objective: To determine whether dose escalation of carmustine in combination with dual-dose O6-benzylguanine to prolong alkyltransferase inhibition could reach an MTD.

    Design, Setting, And Participants: A single-arm phase 1-2 clinical trial conducted at a university teaching hospital enrolled 17 adults with stage IA or stage IIA cutaneous T-cell lymphoma, MF type, to evaluate treatment using topical carmustine plus 2 subsequent daily doses of intravenous O6-benzylguanine, administered every 2 weeks for up to 24 weeks (12 cycles). Read More

    Effectiveness of photodynamic therapy in refractory plaque-stage mycosis fungoides associated with Bowen's disease.
    Dermatol Ther 2017 Feb 15. Epub 2017 Feb 15.
    Department of Clinical-Surgical, Diagnostic and Pediatric Science, Institute of Dermatology, Fondazione IRCCS Policlinico San Matteo, University of Pavia, Pavia, Italy.

    Psoralen with ultraviolet A (PUVA)-induced apoptosis of cutaneous lymphoma cell lines is augmented by type I interferons via the JAK1-STAT1 pathway.
    Photodermatol Photoimmunol Photomed 2017 Feb 14. Epub 2017 Feb 14.
    Department of Dermatology, Bispebjerg Hospital, Bispebjerg Bakke 23, Copenhagen, Denmark.
    Background: Photochemotherapy with psoralen and ultraviolet A (PUVA), with or without adjuvant interferon-α (IFN-α), is a first line therapy for early stage mycosis fungoides and other forms of cutaneous T-cell lymphoma (CTCL). However, the mechanism by which PUVA with IFN-α work in CTCL is poorly understood.

    Purpose: To develop a model to investigate the mechanisms of PUVA and PUVA with IFN-α in CTCL cells. Read More

    The role of histological presentation in erythroderma.
    Int J Dermatol 2017 Feb 12. Epub 2017 Feb 12.
    St. Petersburg State Pediatric Medical University, Saint Petersburg, Russia.
    Background: Erythroderma is a serious medical condition characterized by inflamed red skin involving over 90% of the body. It can be the common presentation of different diseases, therefore clinical diagnosis can be problematic. Controversial data are reported regarding the diagnostic value of histological examination in erythroderma subjects. Read More

    Aggressive cutaneous T-cell lymphomas.
    Semin Diagn Pathol 2016 Dec 24. Epub 2016 Dec 24.
    Ackerman Academy of Dermatopathology, 145 East 32nd, St 10th floor, New York, 10016, NY, USA. Electronic address:
    Cutaneous T cell lymphomas (CTCLs) are heterogeneous, with a prognosis determined in large part by combined clinical, histopathologic, and immunophenotypic features. They are classified under the WHO-EORTC classification of primary cutaneous lymphoma. Whether or not a patient diagnosed with CTCL will experience an aggressive course may not be completely predictable; however, certain subtypes have been proven to be associated with a poor response to therapy and/or short survival. Read More

    Morbidity and Causes of Death in Patients with Cutaneous T-cell Lymphoma in Finland.
    Acta Derm Venereol 2017 Feb 8. Epub 2017 Feb 8.
    Department of Dermatology, Center of Inflammation, Skin and Allergy Hospital, FIN-00250 Helsinki, Finland.
    Cutaneous T-cell lymphomas (CTCL), especially mycosis fungoides, can be considered as a state of longstanding low-grade systemic inflammation. Many studies have focused on secondary cancers with CTCL, but information about comorbidities is limited. A total of 144 patients with CTCL at Helsinki University Central Hospital during 2005 to 2015 were studied to determine associated comorbidities and causes of death in this cohort. Read More

    Unilesional plantar mycosis fungoides treated with topical photodynamic therapy - case report and review of the literature.
    J Eur Acad Dermatol Venereol 2017 Feb 6. Epub 2017 Feb 6.
    Dermatology Practice Schaffhauserplatz, Zurich, Switzerland.
    Background: Unilesional mycosis fungoides (UMF) and pagetoid reticulosis (PR) are variants of mycosis fungoides. Conventional therapy comprises surgical excision or radiotherapy which may be associated with long-term side effects, especially when the lesion is located at a special site like the palms and soles. Therefore, alternative treatment options are needed to treat solitary lesions in the case of UMF or PR. Read More

    Zosteriform Mycosis Fungoides: A New Clinical Presentation With a Dermatomal Distribution.
    Am J Dermatopathol 2016 Dec 29. Epub 2016 Dec 29.
    *Department of Dermatology, Stanford University School of Medicine, Redwood City, CA; and †Department of Pathology, Stanford University School of Medicine, Stanford, CA.
    Classic mycosis fungoides (MF) presents with patches and plaques on the trunk and proximal extremities. However, numerous clinicopathologic variants have been described, making diagnosis challenging. Here, the authors report a 21-year-old woman with immunophenotypically and molecularly confirmed MF occurring in a dermatomal distribution. Read More

    Zosteriform Mycosis Fungoides: A New Clinical Presentation With a Dermatomal Distribution.
    Am J Dermatopathol 2017 Feb;39(2):e17-e18
    *Department of Dermatology, Stanford University School of Medicine, Redwood City, CA; and †Department of Pathology, Stanford University School of Medicine, Stanford, CA.
    Classic mycosis fungoides (MF) presents with patches and plaques on the trunk and proximal extremities. However, numerous clinicopathologic variants have been described, making diagnosis challenging. Here, the authors report a 21-year-old woman with immunophenotypically and molecularly confirmed MF occurring in a dermatomal distribution. Read More

    Total skin electron therapy as treatment for epitheliotropic lymphoma in a dog.
    Vet Dermatol 2017 Jan 29. Epub 2017 Jan 29.
    Department of Pathobiology, College of Veterinary Medicine, University of Florida, 2015 SW 16th Avenue, Gainesville, FL, 32610, USA.
    Background: Mycosis fungoides (MF) is an uncommon cutaneous neoplasm in dogs. Treatment options are limited. Total skin electron therapy (TSET) has been suggested as a possible therapy for canine MF. Read More

    Recommendations for treatment in Folliculotropic Mycosis Fungoides: Report of the Dutch Cutaneous Lymphoma Group.
    Br J Dermatol 2017 Jan 28. Epub 2017 Jan 28.
    Department of Dermatology, Leiden University Medical Center, The Netherlands.
    Background: Folliculotropic mycosis fungoides (FMF) is an aggressive variant of mycosis fungoides (MF) and generally less responsive to standard skin-directed therapies (SDTs). Recent studies distinguished an indolent (early-stage FMF) and a more aggressive (advanced-stage FMF) subgroup. The optimal treatment for both subgroups needs still to be defined. Read More

    Primary cutaneous aggressive epidermotropic cytotoxic T-cell lymphomas: reappraisal of a provisional entity in the 2016 WHO classification of cutaneous lymphomas.
    Mod Pathol 2017 Jan 27. Epub 2017 Jan 27.
    Department of Dermatology and Pathology, Stanford University, Stanford, CA, USA.
    Primary cutaneous CD8-positive aggressive epidermotropic T-cell lymphoma is a rare and poorly characterized variant of cutaneous lymphoma still considered a provisional entity in the latest 2016 World Health Organization Classification of Cutaneous lymphomas. We sought to better characterize and provide diagnostic and therapeutic guidance of this rare cutaneous lymphoma. Thirty-four patients with a median age of 77 years (range 19-89 years) presented primarily with extensive annular necrotic plaques or tumor lesions with frequent mucous membrane involvement. Read More

    Apoptosis Induction and Gene Expression Profile Alterations of Cutaneous T-Cell Lymphoma Cells following Their Exposure to Bortezomib and Methotrexate.
    PLoS One 2017 20;12(1):e0170186. Epub 2017 Jan 20.
    Second Dept. of Internal Medicine and Research Institute, Attikon University General Hospital, Rimini 1, Haidari, Athens, Greece.
    Mycosis fungoides (MF) and its leukemic variant Sézary syndrome (SS) comprise the majority of CTCL, a heterogenous group of non-Hodgkins lymphomas involving the skin. The CTCL's resistance to chemotherapy and the lack of full understanding of their pathogenesis request further investigation. With the view of a more targeted therapy, we evaluated in vitro the effectiveness of bortezomib and methotrexate, as well as their combination in CTCL cell lines, regarding apoptosis induction. Read More

    Gain of CD26 expression on the malignant T-cells in relapsed erythrodermic leukemic mycosis fungoides.
    J Cutan Pathol 2017 Jan 13. Epub 2017 Jan 13.
    Department of Dermatology, Perelman School of Medicine, University of Pennsylvania, Philadelphia, Pennsylvania.
    Loss of CD26 surface expression on the circulating malignant T-cell is the most widely accepted diagnostic marker in patients with leukemic cutaneous T-cell lymphoma (CTCL). CTCL cases with reemergence of CD7 and/or CD26 surface expression are unusual and of uncertain prognosis. We report the case of an erythrodermic leukemic mycosis fungoides patient who had achieved temporary remission after several months on multimodality immunotherapy and extracorporeal photopheresis, but who relapsed with aggressive disease phenotypically characterized by CD4+ T-cells with high CD26 expression. Read More

    Maintenance phase in PUVA phototherapy of early stage mycosis fungoides. A critically appraised topic.
    Br J Dermatol 2017 Jan 12. Epub 2017 Jan 12.
    Division of Dermatology, Department of Surgery and Translational Medicine, University of Florence Medical School, Florence, Italy.
    A 65-years-old patient affected by mycosis fungoides stage IB achieved complete remission after a cycle of PUVA phototherapy. As suggested by USCLC guidelines(1) , the patient should be kept in maintenance phase, defined as "period of gradual decrease of frequency of UVL while in clinical remission before discontinuation of phototherapy" by slowly tapering the number of PUVA applications over time up to clinical relapse. USCLC also suggest a standardized schedule for maintenance phase (table 1). Read More

    Mycosis Fungoides of the Oral Cavity: Fungating Tumor Successfully Treated with Electron Beam Radiation and Maintenance Bexarotene.
    Case Rep Dermatol Med 2016 15;2016:5857935. Epub 2016 Dec 15.
    The University of Texas MD Anderson Cancer Center, Houston, TX, USA.
    Oral involvement in mycosis fungoides is unusual and portends a poor prognosis. The clinical findings of three new cases are described along with a differential diagnosis and review of the literature. For brevity, only one patient is discussed in detail below whereas the other two cases are solely described in table form. Read More

    Donor-derived mycosis fungoides following reduced intensity haematopoietic stem cell transplantation from a matched unrelated donor.
    BMJ Case Rep 2017 Jan 10;2017. Epub 2017 Jan 10.
    Institute of Immunology and Immunotherapy, University of Birmingham, Birmingham, UK.
    A 46-year-old woman with a history of dasatinib-resistant chronic myeloid leukaemia, clonal evolution and monosomy 7 underwent reduced intensity conditioned in vivo T-cell-depleted allogeneic haematopoietic stem cell transplantation (HSCT) from a matched unrelated donor. Following the transplantation, she developed recurrent cutaneous graft versus host disease (GvHD), which required treatment with systemic immunosuppression and electrocorporeal photophoresis. Concurrently, she developed a lichenoid rash with granulomatous features suggestive of cutaneous sarcoidosis. Read More

    Toll-like receptor (TLR)7 expression in mycosis fungoides and psoriasis: a case-control study.
    Clin Exp Dermatol 2017 Mar 5;42(2):172-177. Epub 2017 Jan 5.
    Clinical Biochemistry Department, Faculty of Medicine, Cairo University, Cairo, Egypt.
    Background: Toll-like receptors (TLRs) have been implicated in various dermatological diseases. TLR agonists have the capacity to potently activate the innate immune cells of patients with advanced, refractory, cutaneous T-cell lymphoma (CTCL).

    Aim: To detect TLR7 gene expression in mycosis fungoides (MF) (a neoplastic skin condition) and to compare it with psoriasis (an inflammatory skin condition) in an attempt to clarify the pathogenic role played by TLR7 in both conditions. Read More

    SU-F-T-82: Dosimetric Evaluation of a Shield Used for Hemi-Body Skin Electron Irradiation.
    Med Phys 2016 Jun;43(6):3480
    Roswell Park Cancer Institute, Buffalo, NY.
    Purpose: We had several mycosis fungoides patients with a limited disease to about half of the skin surface. A custom-made plywood shield was used to protect the non-targeted skin region with our total skin electron irradiation (TSEI) technique. We report a dosimetric evaluation for our "hemi-body" skin electron irradiation technique. Read More

    Childhood Hypopigmented Mycosis Fungoides: A Rare Diagnosis.
    Case Rep Pediatr 2016 29;2016:8564389. Epub 2016 Nov 29.
    Pediatrics Department, Portuguese Oncology Institute of Porto Francisco Gentil, 4200-072 Porto, Portugal.
    Primary cutaneous lymphomas (PCL) are rare in pediatrics. Mycosis fungoides (MF) is the most frequent PCL diagnosed in childhood. There are various clinical variants of MF, including the hypopigmented MF (HMF). Read More

    A new molecular paradigm in mycosis fungoides and Sézary syndrome.
    Semin Diagn Pathol 2016 Dec 7. Epub 2016 Dec 7.
    Department of Internal Medicine, University of Michigan Medical School, Ann Arbor, MI 48105, USA.
    Mycosis Fungoides (MF) and Sézary Syndrome (SS) are clonal proliferations of mature T-cells manifesting as lymphoproliferative disorders in which the neoplastic cells show a strong propensity for skin-homing. While the predominant site of presentation in MF is the skin, the peripheral blood carries a significant tumor burden in Sézary Syndrome such that it resembles a "leukemic" disease. While the genetic basis of these diseases has been studied using different approaches in the previous years, recent genome-wide studies employing massively parallel sequencing techniques now offer new insights into the molecular pathogenesis of these diseases. Read More

    Biopsy correlation of surface area vs single axis measurements on CT scan of lymph nodes in patients with erythrodermic mycosis fungoides and Sezary syndrome.
    Br J Dermatol 2016 Dec 23. Epub 2016 Dec 23.
    Department of Dermatology, University Hospitals Birmingham, UK.
    Sezary syndrome (SS) presents with erythroderma, leukaemic blood involvement and frequent lymphadenopathy whilst 15% of mycosis fungoides (MF) patients present with erythroderma(1) . Staging of patients with erythrodermic (e)MF/SS includes IIIA, IIIB, IVA or IVB dependant on blood, lymph node (LN) or visceral involvement(2) . In MF/SS; an abnormal LN is either firm, irregular, clustered, or fixed on examination or ≥15mm on imaging. Read More

    Brentuximab vedotin for treatment of non-Hodgkin lymphomas: A systematic review.
    Crit Rev Oncol Hematol 2017 Jan 21;109:42-50. Epub 2016 Nov 21.
    Hematology, Oncology, Blood & Marrow Transplantation, Department of Medicine, University of Arizona, Tucson, AZ, 85721, United States. Electronic address:
    Background: Brentuximab vedotin (BV) is an antibody-drug conjucate (ADC) comprising a CD30-directed antibody, conjugated to the microtubule-disrupting agent MMAE via a protease cleavable linker. BV is FDA approved for use in relapsed classical Hodgkin lymphoma (HL) and relapsed systemic anaplastic large cell lymphoma (sALCL). There are multiple publications for its utility in other malignancies such as diffuse large B-cell lymphoma (DLBCL), mycosis fungoides (MF), Sézary syndrome (SS), T-cell lymphomas (TCL), primary mediastinal lymphoma (PMBL), and post-transplant lymphoproliferative disorders (PTLD). Read More

    Follicular lymphomatoid papulosis with follicular mucinosis: a clinicopathologic study of 3 cases with literature review and conceptual reappraisal.
    J Cutan Pathol 2016 Dec 23. Epub 2016 Dec 23.
    Department of Dermatology, University of Iowa, Iowa City, Iowa.
    Lymphomatoid papulosis (LyP), characterized by recurring, waxing and waning, cutaneous papulonodules, is increasingly recognized to represent a heterogeneous collection of pathologically dissimilar subtypes. Recently, a follicular LyP variant was proposed, featuring folliculotropism. Folliculotropism by atypical lymphocytes is conventionally associated with follicular mucinosis and mycosis fungoides (MF), and review of the literature suggests co-occurrence of folliculotropism and follicular mucinosis in LyP to be rare, with only 3 cases identified to date. Read More

    Systemic therapy for cutaneous T-cell lymphoma: who, when, what, and why?
    Expert Rev Hematol 2017 Feb 26;10(2):111-121. Epub 2016 Dec 26.
    b Department of Internal Medicine, Division of Hematology , The Ohio State University , Columbus , OH , USA.
    Introduction: CTCL are rare neoplasms. Optimal care requires integrated use of diagnostic and treatment modalities spanning multiple specialties. Current instruments for patient risk stratification and disease measurement across all anatomical compartments are suboptimal. Read More

    Romidepsin Controls Chronic Lymphocytic Leukemia in a Patient with Mycosis Fungoides.
    Hematol Rep 2016 Nov 2;8(4):6840. Epub 2016 Nov 2.
    Department of Dermatology, University of Pittsburgh , Pittsburgh, PA, USA.
    Romidepsin belongs to a class of medications called histone deacetylase inhibitors and is currently approved for treatment of cutaneous and peripheral T-cell lymphomas. Romidepsin was previously investigated for the treatment of chronic lymphocytic leukemia (CLL), and demonstrated potential benefit, but interest in its use declined following phase I clinical trials that showed poor tolerance of a significant side effect profile. We presented a patient with a history of stage II CLL, referred to dermatology for treatment of new-onset of mycosis fungoides (MF), who was treated with romidepsin over seven months. Read More

    Latest insights into pathogenesis of mycosis fungoides and cutaneous T-cell lymphoma.
    G Ital Dermatol Venereol 2017 Apr 16;152(2):158-168. Epub 2016 Dec 16.
    Department of Hematology Oncology, Levine Cancer Institute, Charlotte, NC, USA -
    Cutaneous T-cell lymphoma (CTCL) is a rare but increasing malignancy whose protean manifestations necessarily present in the integument, but can also spread to involve blood, lymph nodes and internal organs. We have developed efficacious and varied therapies to treat early and advanced stage disease, but there are still many who suffer tremendously from this illness. Although the pathogenesis of this cancer remains frustratingly elusive, over the last 200 years we have generated a robust body of evidence that points toward possible singular as well as multifactorial etiologies. Read More

    Past, present and future of cutaneous lymphomas.
    Semin Diagn Pathol 2016 Nov 28. Epub 2016 Nov 28.
    Research Unit Dermatopathology, Department of Dermatology, Medical University of Graz, Auenbruggerplatz 8, 8036 Graz, Austria. Electronic address:
    Primary cutaneous lymphomas represent a broad group of diseases with different clinical, histopathological, phenotypic, molecular, and prognostic features. All cutaneous lymphomas share the same tropism of neoplastic lymphocytes for the skin, but precise classification is paramount for proper management of the patients. Primary cutaneous lymphomas are classified according to the schemes proposed by the European Organization for Research and Treatment of Cancer (EORTC)-Cutaneous Lymphomas Task Force together with the World Health Organization (WHO) in 2005, and the WHO classification of 2008 with the 2016 update. Read More

    Cutaneous lymphoma: Kids are not just little people.
    Clin Dermatol 2016 Nov - Dec;34(6):749-759. Epub 2016 Jul 10.
    Department of Dermatology, University of Connecticut School of Medicine, 263 Farmington Ave, Farmington, CT 06030.
    Cutaneous T-cell lymphomas (CTCLs) are non-Hodgkin lymphomas that predominantly affect older patients. Onset of cutaneous lymphoma in childhood is rare, but it can present as early as the first decade of life. In both adults and children, the diagnosis of cutaneous lymphoma can be challenging because inflammatory dermatoses can mimic CTCL both clinically and histologically. Read More

    Dosimetric comparison of intensity-modulated radiotherapy (IMRT) and volumetric modulated arc therapy (VMAT) in total scalp irradiation: a single institutional experience.
    Radiat Oncol J 2016 Dec 14;34(4):313-321. Epub 2016 Dec 14.
    Department of Radiation Oncology, Faculty of Medicine, Martin Luther University Halle-Wittenberg, Halle, Germany.
    Purpose: Total scalp irradiation (TSI) is a rare but challenging indication. We previously reported that non-coplanar intensity-modulated radiotherapy (IMRT) was superior to coplanar IMRT in organ-at-risk (OAR) protection and target dose distribution. This consecutive treatment planning study compared IMRT with volumetric-modulated arc therapy (VMAT). Read More

    A Rare Case of Mycosis Fungoides in the Oral Cavity and Small Intestine Complicated by Perforation.
    Case Rep Dermatol 2016 Sep-Dec;8(3):294-302. Epub 2016 Nov 14.
    The University of Texas MD Anderson Cancer Center, Houston, TX, USA.
    Extracutaneous involvement in mycosis fungoides (MF) carries a poor prognosis. Oral and gastrointestinal (GI) tract lesions are both rare locations of disease. We describe the clinical findings of one case with oral and GI MF complicated by perforation after systemic antineoplastic treatment, and review the relevant literature. Read More

    A Clinicopathological Analysis of Primary Cutaneous Lymphomas: A 6-year Observational Study at a Tertiary Care Center of South India.
    Indian J Dermatol 2016 Nov-Dec;61(6):608-617
    Department of Pathology, Government Medical College, Kozhikode, Kerala, India.
    Background: Little data are available concerning clinical and pathological patterns of cutaneous lymphomas in India.

    Aim: To analyze the clinical and histopathological characteristics of cutaneous lymphomas in Indian patients.

    Materials And Methods: This is a single-center, prospective, observational study carried out from January 1, 2010, to December 31, 2015. Read More

    The biomarker landscape in mycosis fungoides and Sézary syndrome.
    Exp Dermatol 2016 Nov 28. Epub 2016 Nov 28.
    Department of Dermatology, University of Pittsburgh, Pittsburgh, PA, USA.
    The practice of pre-emptive individualized medicine is predicated on the discovery, development and application of biomarkers in specific clinical settings. Mycosis fungoides and Sézary syndrome are the two most common type of cutaneous T-cell lymphoma, yet diagnosis, prognosis and disease monitoring remain a challenge. In this review, we discuss the current state of biomarker discovery in mycosis fungoides and Sézary syndrome, highlighting the most promising molecules in different compartments. Read More

    Lymphoma of the eyelid.
    Surv Ophthalmol 2016 Nov 26. Epub 2016 Nov 26.
    Department of Pathology, Rigshospitalet, University of Copenhagen, Copenhagen, Denmark; Department of Ophthalmology, Rigshospitalet, University of Copenhagen, Copenhagen, Denmark. Electronic address:
    Lymphoma of the eyelid constitutes 5% of ocular adnexal lymphoma. In previously published cases, 56% of lymphomas of the eyelid are of B-cell origin and 44% are of T-cell origin. The most frequent B-cell lymphomas are extranodal marginal zone lymphoma (27 cases-14%) and diffuse large B-cell lymphoma (18 cases-9%). Read More

    Eczema and Urticaria as Manifestations of Undiagnosed and Rare Diseases.
    Pediatr Clin North Am 2017 Feb;64(1):39-56
    Section of Pediatric Dermatology, Department of Dermatology, Medical College of Wisconsin, 9200 West Wisconsin Avenue, Milwaukee, WI 53226, USA; Department of Pediatrics, Medical College of Wisconsin, Milwaukee, WI, USA. Electronic address:
    Eczema and urticaria are common disorders encountered in pediatric patients, but they may occasionally be the presenting complaint in a child with an underlying rare disease. Immunodeficiency syndromes should be suspected when eczema is associated with neonatal onset, recurrent infections, chronic lymphadenopathy, or failure to thrive. Nutritional deficiencies and mycosis fungoides are in the differential diagnosis for a child with a recalcitrant eczematous eruption. Read More

    TP53 Gene Status Affects Survival in Advanced Mycosis Fungoides.
    Front Med (Lausanne) 2016 11;3:51. Epub 2016 Nov 11.
    Department of Dermatology, Bispebjerg Hospital, Copenhagen, Denmark; Division of Dermatology, Faculty of Medicine and Dentistry, University of Alberta, Edmonton, AB, Canada.
    TP53 is frequently mutated in different types of neoplasms including leukemia and lymphomas. Mutations of TP53 have also been reported in mycosis fungoides (MF), the most common type of cutaneous lymphoma. However, little is known about the frequency, spectrum of mutations, and their prognostic significance in MF. Read More

    Photodynamic therapy as an alternative treatment for relapsed or refractory mycosis fungoides: a systemic review.
    Photodiagnosis Photodyn Ther 2016 Nov 22. Epub 2016 Nov 22.
    Department of Dermatology, Peking Union Medical College Hospital, Peking Union Medical College and Chinese Academy of Medical Sciences, Beijing 100730, China. Electronic address:
    Mycosis fungoides is the most common cutaneous T-cell lymphoma. It is characterized by slow progress over years to decades, developing from patches to infiltrated plaques, and sometimes to tumors. Therapies such as localized chemotherapy, photochemotherapy and radiotherapy are often employed when lesions of refractory or relapsing mycosis fungoides are resistant to conventional therapies. Read More

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