Cell Mol Life Sci 2017 Sep 15. Epub 2017 Sep 15.

Department of Dermatology, Course of Integrated Medicine, Graduate School of Medicine, Osaka University, 2-2 Yamadaoka, Suita, Osaka, 5650871, Japan.

Skin is an organ that is susceptible to damage by external injury, chronic inflammation, and autoimmunity. Tissue damage causes alterations in both the configuration and type of cells in lesional skin. This phenomenon, called tissue remodeling, is a universal biological response elicited by programmed cell death, inflammation, immune disorders, and tumorigenic, tumor proliferative, and cytoreductive activity. Read More

Front Immunol 2017 30;8:1010. Epub 2017 Aug 30.

INSERM U976, Hôpital Saint-Louis, Paris, France.

KIR3DL2 is a member of the killer cell immunoglobulin-like receptor (KIR) family that was initially identified at the surface of natural killer (NK) cells. KIR3DL2, also known as CD158k, is expressed as a disulfide-linked homodimer. Each chain is composed of three immunoglobulin-like domains and a long cytoplasmic tail containing two immunoreceptor tyrosine-based inhibitory motifs. Read More

Photodiagnosis Photodyn Ther 2017 Sep 7. Epub 2017 Sep 7.

Dermatology Unit, Department of Specialised, Experimental and Diagnostic Medicine, University of Bologna, Bologna, Italy.

Background: Photodynamic therapy (PDT) is a well-known and effective treatment for non-melanoma skin-cancer. Numerous studies have also shown its effectiveness in mycosis fungoides. The aim of the study was to analyse MF patients treated with PDT at the Dermatology Unit of Bologna University. Read More

Br J Dermatol 2017 Sep 10. Epub 2017 Sep 10.

Department of Dermatology, Venerology, Allergology and Phlebology, Johannes Wesling Medical Centre, University Hospital of Ruhr-University, Bochum, Germany.

We thank the authors Lewis, Kim, and Duvic, for their reaction to our article. The increasingly personalised medicine should also take into account individual tumour entities and their inter-individual pathways. Therefore, we can only welcome and sustain the comments. Read More

Br J Dermatol 2017 Sep 10. Epub 2017 Sep 10.

Department of Dermatology, The University of Texas MD Anderson Cancer Center, Houston, TX, USA.

Stranzenbach et al. propose alternate dosing regimens of brentuximab vedotin (BV) for CD30+ cutaneous T-cell lymphomas (CTCLs) such as mycosis fungoides (MF) and primary cutaneous anaplastic large cell lymphoma (pcALCL).(1) They emphasize that lower doses or less frequent dosing schedules for CTCL may be equally effective while limiting adverse events. Read More

Invest New Drugs 2017 Sep 8. Epub 2017 Sep 8.

Laboratory for Molecular Dermatology, Felsenstein Medical Research Center, Petach Tikva and Sackler Faculty of Medicine, Tel Aviv University, Tel Aviv, Israel.

We previously found that the novel histone deacetylase inhibitor (HDACI) butyroyloxymethyl diethylphosphate (AN-7) had greater selectivity against cutaneous T-cell lymphoma (CTCL) than SAHA. AN-7 synergizes with doxorubicin (Dox), an anthracycline antibiotic that induces DNA breaks. This study aimed to elucidate the mechanism underlying the effect of AN-7 on Dox-induced double-strand DNA breaks (DSBs) in CTCL, MyLa and Hut78 cell lines. Read More

Am J Hematol 2017 Oct;92(10):1085-1102

Division of Hematology/Oncology, University of Michigan Comprehensive Cancer Center, Ann Arbor, Michigan, 48109-5948.

Disease Overview: Cutaneous T-cell lymphomas are a heterogenous group of T-cell lymphoproliferative disorders involving the skin, the majority of which may be classified as Mycosis Fungoides (MF) or Sézary Syndrome (SS).

Diagnosis: The diagnosis of MF or SS requires the integration of clinical and histopathologic data.

Risk-adapted Therapy: TNMB (tumor, node, metastasis, blood) staging remains the most important prognostic factor in MF/SS and forms the basis for a "risk-adapted," multi-disciplinary approach to treatment. Read More

Medicine (Baltimore) 2017 Sep;96(35):e7890

aDepartment of Head Neck Surgery, Hainan Cancer Hospital, Haikou, Hainan bDepartment of Oral and Maxillofacial Surgery, the First Affiliated Hospital of Nanchang University, Nanchang, Jiangxi, China.

Rationale: Lymphomas take up about 14% of all head-neck malignancies, out of which 97% are non-Hodgkin lymphomas (NHL). The clinical courses, treatment responses, and prognoses of NHLs vary with different subtypes and anatomic sites. In the Chinese population (including the Taiwanese), head-neck NHLs are often seen with the tonsils, nasal cavity, nasal sinus, and the nasopharynx. Read More

G Ital Dermatol Venereol 2017 Jul 28. Epub 2017 Jul 28.

Department of Dermatology and Venereology, Karl Landsteiner University of Health Sciences, University Hospital of St. Pölten, St. Pölten, Austria -

Mycosis fungoides (MF), the most common variant of among cutaneous T cell lymphomas (CTCL), is characterised in its early stages by clonal proliferation of malignant T-cells in the skin manifesting as erythematous patches and plaques with a chronic course and progression to cutaneous tumors and extracutaneous organs in some patients. Skin directed therapies (SDT) are primarily used for effective palliation in early stage disease. Phototherapy with ultraviolet A radiation combined with 8-methoxypsoralen (PUVA) and with ultraviolet B radiation (UVB) has a longstanding history in the treatment of MF and are highly effective in inducing remissions. Read More

Int J Radiat Oncol Biol Phys 2017 Jun 9. Epub 2017 Jun 9.

Guy's and St Thomas' NHS Foundation Trust, London, UK.

Purpose: Total skin electron beam radiation therapy (TSEB) is a very effective treatment of mycosis fungoides. Following reports of similar durations of response to lower doses of TSEB, a low-dose schedule of TSEB was introduced in the United Kingdom.

Methods And Materials: A protocol of 12 Gy in 8 fractions over a period of 2 weeks was agreed on by use of the Stanford University technique. Read More

J Dtsch Dermatol Ges 2017 Aug 18. Epub 2017 Aug 18.

Department of Dermatology, Venereology, and Allergology, University Medical Center Heidelberg, Heidelberg, Germany.

Br J Dermatol 2017 Aug;177(2):337-338

Photobiology Unit, Department of Dermatology, Ninewells Hospital and Medical School, Dundee, DD1 9SY, U.K.

Br J Dermatol 2017 Aug;177(2):336-337

Department of Dermatology, Medical University of Graz, Graz, Austria.

Turk J Haematol 2017 Aug 23. Epub 2017 Aug 23.

Hautarzt 2017 Aug 22. Epub 2017 Aug 22.

Universitätsklinik für Dermatologie, Venerologie, Allergologie und Phlebologie, Mühlenkreiskliniken, Minden, Deutschland.

Background: Cutaneous lymphomas are rare skin cancers with a wide clinical spectrum.

Objective: To give an overview of the current classification and the clinical spectrum of cutaneous lymphomas.

Material And Methods: Analysis and summary of the current literature concerning the different entities of cutaneous lymphomas. Read More

Expert Opin Biol Ther 2017 Aug 28:1-8. Epub 2017 Aug 28.

a Unit of Dermatology, Department of Medicine , University of Padua , Padua , Italy.

Introduction: Cutaneous T-cell lymphomas (CTCLs) comprise of a group of rare and heterogeneous skin lymphoproliferative disorders derived from skin resident T cells. Treatment of CTCLs is based on skin-directed approaches and/or systemic therapies. Advanced CTCLs are difficult to treat with the currently available treatments as they generally fail to obtain prolonged clinical remission. Read More

Future Oncol 2017 Aug 14. Epub 2017 Aug 14.

Dermatology - University Hospitals Birmingham NHS Foundation Trust, University Hospital Birmingham, Birmingham, B15 2TH, UK.

CD30-positive primary cutaneous T-cell lymphoma (CTCL) includes mycosis fungoides, anaplastic large-cell lymphoma and lymphomatoid papulosis type A. Brentuximab vedotin (BV) consists of an antibody targeting CD30 with a protease-cleavable linker to vedotin. CD30 binding allows internalization of BV inducing cell-cycle arrest and apoptosis. Read More

Pediatr Dermatol 2017 Sep 14;34(5):e260-e264. Epub 2017 Aug 14.

Cutaneous Lymphoma Program, Department of Dermatology, University of Pittsburgh, Pittsburgh, Pennsylvania.

Hypopigmented mycosis fungoides (HMF) is the most common variant of mycosis fungoides (MF) in children. Large-cell transformation in HMF has never been reported. Herein we report a case of HMF in an 8-year-old boy who presented with a 6-year history of hypopigmented patches on the bilateral arms, lower back, buttocks, posterior thighs, and lower legs. Read More

Pediatr Dermatol 2017 Sep 14;34(5):547-553. Epub 2017 Aug 14.

Department of Dermatology, Memorial Sloan Kettering Cancer Center and Weill Cornell Medical College, New York, New York.

Background/objectives: Mycosis fungoides (MF) in young patients is rare and may have atypical presentations. There are limited data in these patients. The objective was to determine the clinical outcome and prognosis of young patients with MF. Read More

Clin Lab Med 2017 Sep;37(3):527-546

Department of Pathology, Memorial Sloan Kettering Cancer Center, 1275 York Avenue, New York, NY 10065, USA. Electronic address:

Cutaneous T-cell lymphomas comprise a heterogeneous group of diseases characterized by monoclonal proliferations of T lymphocytes primarily involving skin, modified skin appendages, and some mucosal sites. This article addresses the basic clinical, histologic, and immunohistochemical characteristics of this group of diseases, with additional attention to evolving literature on dermoscopy, reflectance confocal microscopy, flow cytometry, and molecular data that may increasingly be applied to diagnostic and therapeutic algorithms in these diseases. Select unusual phenotypes or diagnostic examples of classic phenotypes are demonstrated, and flags for consideration while making a pathologic diagnosis of cutaneous T-cell lymphoma are suggested. Read More

Eur J Cancer 2017 Aug 7;84:81-87. Epub 2017 Aug 7.

Division of Clinical Epidemiology and Aging Research, German Cancer Research Center (DKFZ), Heidelberg, Germany; German Cancer Consortium (DKTK), German Cancer Research Center (DKFZ), Heidelberg, Germany; Division of Preventive Oncology, German Cancer Research Center (DKFZ) and National Center for Tumor Diseases (NCT), Heidelberg, Germany.

Introduction: Population-level survival has improved for common haematologic malignancies in the early 21st century. However, relatively few population-level data are available for rare haematologic malignancies.

Methods: Data were extracted from 12 cancer registries in Germany and the Surveillance, Epidemiology and End Results database in the United States (US). Read More

Arch Dermatol Res 2017 Aug 10. Epub 2017 Aug 10.

Department of Dermatology, University of Medical Sciences, Poznań, Poland.

The aim of the present study was to assess the effectiveness of UVA1 and PUVA therapy in treating patients with mycosis fungoides (MF) and to evaluate high-frequency ultrasonography (HF-USG) to monitor the clinical response of these patients. A total of 18 patients diagnosed with MF (stages I-IIA) underwent phototherapy, either UVA1 (6 cases) or PUVA (12 cases). Clinical response was evaluated according to modified Severity Weighted Assessment Tool (mSWAT) criteria and HF-USG (20 MHz). Read More

Biol Blood Marrow Transplant 2017 Aug 7. Epub 2017 Aug 7.

Vanderbilt University Medical Center, Nashville, Tennessee.

Recognizing the significant biological and clinical heterogeneity of mature T cell and natural killer (NK)/T cell lymphomas, the American Society for Blood and Marrow Transplantation invited experts to develop clinical practice recommendations related to the role of autologous hematopoietic cell transplantation (auto-HCT) and allogeneic HCT (allo-HCT) for specific histological subtypes. We used the GRADE methodology to aid in moving from evidence to decision making and ultimately to generating final recommendations. Auto-HCT in front-line consolidation is recommended in peripheral T cell lymphoma not otherwise specified (PTCL-NOS), angioimmunoblastic T cell lymphoma (AITL), anaplastic large cell lymphoma-anaplastic lymphoma kinase (ALCL-ALK)-negative, NK/T cell (disseminated), enteropathy-associated T cell lymphoma (EATL), and hepatosplenic lymphomas. Read More

J Cutan Pathol 2017 Aug 10. Epub 2017 Aug 10.

Pathology and Laboratory Medicine Service, James A Haley VA Hospital, Tampa, Florida.

Background: Digital pathology offers numerous advantages, allowing remote information sharing using whole slide imaging (WSI) to digitize an entire glass slide (GS) at high resolution, creating a digital slide (DS).

Methods: In this study, we examine the concordance in diagnoses made on 40 digital slides (DSs) vs traditional GSs in differentiating between spongiotic dermatitis (SD) and patch/plaque-stage mycosis fungoides (MF).

Results: Greater interobserver concordance rate in final diagnosis of SD vs MF was observed with the utilization of DS (86. Read More

J Dermatolog Treat 2017 Aug 29:1-5. Epub 2017 Aug 29.

a Department of Dermatology , University of Pittsburgh , Pittsburgh , PA , USA.

Background: Phototherapy has been a mainstay in the treatment of mycosis fungoides (MF). However, the recent findings of UV-induced p53 mutations in advanced MF suggest that phototherapy may contribute to disease progression.

Objective: The objective of this study was to evaluate the effect of phototherapy on the time to tumor progression and overall survival in MF. Read More

Hautarzt 2017 Aug 2. Epub 2017 Aug 2.

Klinik für Dermatologie und Venerologie, HELIOS Klinikum Krefeld, Krefeld, Deutschland.

Adequate therapeutic management of cutaneous T-cell lymphoma (CTCL) requires the identification of the exact CTCL stage and entity within the current WHO classification. There is no curative therapy for CTCL yet, so that treatment currently aims at improving symptoms and quality of life as well as reducing relapse rates. The treatment has to be stage-adapted. Read More

Int J Dermatol 2017 Aug 1. Epub 2017 Aug 1.

Department of Dermatology, University of Texas Southwestern, Dallas, TX, USA.

Background: The utility of brentuximab vedotin (BV) in CD30(+) systemic lymphomas is established, however evidence for treating primary cutaneous lymphoma remains limited. This study aimed to evaluate BV in treating CD30(+) transformed mycosis fungoides (MF) and primary cutaneous anaplastic large cell lymphoma (PC-ALCL).

Methods: A literature review was conducted, and we analyzed data from published trials and case reports obtained via search of Ovid-MEDLINE(®) and PubMed databases. Read More

JAAD Case Rep 2017 Jul 20;3(4):358-361. Epub 2017 Jul 20.

Department of Dermatology, The University of Texas MD Anderson Cancer Center, Houston, Texas.

J Mol Biomark Diagn 2017 May 2;8(3). Epub 2017 Mar 2.

University of Colorado School of Medicine in Aurora, USA.

We describe two unique cases of fulminant mycosis fungoides with remarkably similar and aggressive clinical courses resulting in death. Both cases demonstrated ulcerated palmar and periorbital plaques and marked tissue eosinophilia, which was confirmed by T-cell receptor γ chain gene rearrangement studies to display identical monoclonality at temporally and anatomically distinct sites. Dense eosinophilic infiltrates on biopsy led to misdiagnosis of inflammatory dermatoses in both instances. Read More

J Dermatol Sci 2017 Jul 17. Epub 2017 Jul 17.

Department of Dermatology, Hokkaido University Graduate School of Medicine, Sapporo, Japan.

Dermatol Ther 2017 Jul 26. Epub 2017 Jul 26.

Department of Dermatology, The University of Texas MD Anderson Cancer Center, Houston, TX, USA.

Organ transplant recipients receiving immunosuppression have an increased risk of developing post-transplant lymphoproliferative diseases (PTLDs). Traditionally, PTLDs refer to Epstein-Barr virus (EBV)-induced B-cell lymphoma. However, post-transplant T-cell lymphoma may also occur and tends to have a poorer response to reduced immunosuppressive therapy. Read More

Head Neck Pathol 2017 Jul 24. Epub 2017 Jul 24.

Department of Oncology and Diagnostic Sciences, School of Dentistry, University of Maryland, Baltimore, MD, 21201, USA.

Mycosis fungoides (MF) accounts for approximately 50% of all primary cutaneous lymphomas. MF occurrence in the oral cavity is extremely rare with approximately 45 cases reported to date. We present a case of a 68 year-old man with a raised nodular lesion of the ventral tongue with clinical impression of irritational fibroma. Read More

Australas J Dermatol 2017 Jul 21. Epub 2017 Jul 21.

Department of Dermatology, First Affiliated Hospital, Sun Yat-sen University, Guangzhou, China.

Br J Dermatol 2017 Jul;177(1):17-18

Department of Dermatology and Paris 7 University, Inserm U976, 1 Avenue Claude Vellefaux, 75010, Paris, France.

Clin Lymphoma Myeloma Leuk 2017 Sep 19;17(9):604-612. Epub 2017 Jun 19.

Division of Dermatology, Department of Medicine, University of Toronto, Toronto, ON, Canada.

Background: Phototherapy is used frequently to treat early-stage mycosis fungoides (MF). The effectiveness of bath psoralen-ultraviolet A (bath PUVA) and narrowband ultraviolet B (nbUVB) in MF is well established. However, evidence is limited comparing the effectiveness of the 2 modalities for early-stage MF. Read More

J Am Acad Dermatol 2017 Oct 11;77(4):719-727. Epub 2017 Jul 11.

University of Alberta, Edmonton, Canada; Department of Dermatology, University of Copenhagen, Copenhagen, Denmark.

Background: Classic Sézary syndrome (SS) is defined by erythroderma, generalized lymphadenopathy, and leukemic blood involvement. Clinical observations suggest that SS begins as a nonerythrodermic disease.

Objective: To describe the early clinical characteristics of patients with SS. Read More

JAAD Case Rep 2017 Jul 22;3(4):288-290. Epub 2017 Jun 22.

Department of Dermatology, University of California Davis, Sacramento, California.

Am J Dermatopathol 2017 May 18. Epub 2017 May 18.

Departments of *Internal Medicine, and †Dermatology, UC Irvine Health, Irvine, CA.

Syringotropic mycosis fungoides (STMF) is a very rare variant of cutaneous T-cell lymphoma. It follows a much milder disease course than its clinically indistinguishable adnexal counterpart, folliculotropic mycosis fungoides (FMF). We report a case of a 36-year-old man who presented with erythematous, studded papules and plaques on the left upper extremity and right anterior thigh diagnosed as mycosis fungoides (MF) Stage 1A on initial superficial shave biopsy. Read More

Case Rep Dermatol 2017 May-Aug;9(2):35-39. Epub 2017 Jun 8.

Department of Dermatology, CHU Sart Tilman, University of Liège, Liège, Belgium.

Eruptive seborrheic keratoses (ESK) are rare in dermatology. They are usually inflammatory in nature and may be encountered as Leser-Trélat sign. ESK may also be simultaneously observed with hepatic angiomas, chemotherapy, segmental neurofibromatosis, HIV or erythrodermic pityriasis rubra pilaris, psoriasis, and drug eruption. Read More

J Am Acad Dermatol 2017 Sep 1;77(3):489-496. Epub 2017 Jul 1.

Department of Dermatology, Northwestern University, Feinberg School of Medicine, Chicago, Illinois. Electronic address:

Background: The prognosis of the CD8(+) subtype of mycosis fungoides (MF) is controversial. Although most authors believe that determining the presence of this cell surface antigen has no prognostic value, others have observed a more indolent course for CD8(+) MF compared with CD4(+) MF.

Objectives: To review the cases of CD8(+) MF in the pediatric and adult populations seen at our institution. Read More

Postepy Dermatol Alergol 2017 Jun 29;34(3):273-275. Epub 2017 May 29.

Department of Dermatology, Venereology and Allergology, Medical University of Gdansk, Gdansk, Poland.

Clin Lymphoma Myeloma Leuk 2017 Aug 24;17(8):520-526.e2. Epub 2017 Jun 24.

Department of Therapeutic Radiology, Yale School of Medicine, New Haven, CT.

Background: Management of mycosis fungoides and Sézary syndrome (MF/SS) is complex, and randomized evidence to guide treatment is lacking. The institutional treatment volumes for MF/SS might vary widely nationally and influence patient survival.

Patients And Methods: Using the National Cancer Database, we identified patients with a diagnosis of MF/SS from 2004 to 2011 in the United States who had received treatment at a reporting facility. Read More

Am J Dermatopathol 2017 Jun 20. Epub 2017 Jun 20.

*Research Unit Dermatopathology, Department of Dermatology, Medical University of Graz, Graz, Austria; †Anatomic Pathology Unit, Hospital Universitário Polydoro Ernani de São Thiago, Universidade Federal de Santa Catarina, Florianópolis, Brazil; ‡Anatomic Pathology Unit, Macerata General Hospital, Macerata, Italy; §Anatomic Pathology Unit, Department of Surgical Science and Integrated Diagnostics, University of Genoa, IRCCS AOU San Martino IST, Genoa, Italy; ¶Dermatopathology Unit, San Gallicano Dermatology Institute, Rome, Italy; ‖Department of Dermatology, Galliera Hospital, Genoa, Italy; **School of Pathology, University of Milan, Fondazione IRCCS Ca' Granda-Ospedale Maggiore Policlinico, Milan, Italy; and ††Department of Dermatology, Hospital Clínico Universitario Lozano Blesa, Zaragoza, Spain.

The occurrence of pseudolymphomatous infiltrates in cutaneous lupus erythematosus (cLE) is described mainly in lupus panniculitis and lupus tumidus/lymphocytic infiltration of the skin (Jessner-Kanof). We collected 15 cases of pseudolymphomatous cLE other than lupus panniculitis and lupus tumidus (M:F = 4:11; age range: 23-79 years; mean age: 50.9 years; median age: 57 years). Read More

Am J Dermatopathol 2017 Aug;39(8):614-617

*Department of Pathology, Hospital Universitario 12 de Octubre, Facultad de Medicina, Universidad Complutense, Instituto de Investigación I+12, Madrid, Spain; and †Department of Dermatology, Hospital Universitario 12 de Octubre, Facultad de Medicina de la Universidad Complutense, Instituto de Investigación I+12, Madrid, Spain.

The presence of a granulomatous reaction in cutaneous lymphomas has been described in the past, especially in mycosis fungoides (MF), where a "granulomatous" variant of the disease is well known. We describe a patient with granulomatous MF (GMF) who has been followed for 13 years presenting with erythematosquamous plaques on his fingers and toes, ankles, heels, and abdomen, which on microscopic examination showed a lichenoid granulomatous reaction admixed with a neoplastic proliferation of small-sized, atypical CD4 lymphocytes. GMF is characterized by a granulomatous reaction intermingled with the dermal infiltrate of MF which may even reach the subcutaneous tissue. Read More

JAAD Case Rep 2017 Jul 15;3(4):276-279. Epub 2017 Jun 15.

Department of Dermatology, University of Texas MD Anderson Cancer Center, Houston, Texas.

Ann Diagn Pathol 2017 Jun 10;28:54-59. Epub 2017 Feb 10.

Department of Pathology and Laboratory Medicine, New York Presbyterian Hospital-Weill Cornell Medical Center, New York, NY 10065, USA. Electronic address:

Background: Negative immunoregulatory checkpoints impede effective immune responses to tumor and reduce the action of anticancer agents. One such example is programmed death marker-1 (PD-1), an inhibitory signaling receptor expressed on activated and regulatory T-cells. PD-1 expression was reported in a few reports, but the expression profile of PD-1 and mycosis fungoides (MF) remains largely to be characterized. Read More

Ann Dermatol Venereol 2017 Jun 22. Epub 2017 Jun 22.

Service de dermatologie, groupe hospitalier du Havre, hôpital J.-Monod, BP 24, 76083 Le Havre, France.

Background: Skin cancer occurs frequently in organ transplant patients as a result of induced immunosuppression. Most cases involve carcinomas or B-cell lymphomas induced by the Epstein Barr virus (EBV). Cutaneous T-cell lymphomas remain rare. Read More

J Am Acad Dermatol 2017 Sep 20;77(3):497-502.e2. Epub 2017 Jun 20.

Department of Dermatology, The Second Xiangya Hospital, Central South University, Changsha, Hunan, People's Republic of China. Electronic address:

Background: Studies have shown contradictory results regarding the survival outcomes among white, African American, and Asian patients with mycosis fungoides (MF).

Objective: To evaluate the survival outcomes among white, African American, and Asian patients with MF and to determine other prognostic factors of the disease.

Methods: The US National Cancer Database was used to identify patients with histologically confirmed MF from 2004 to 2014. Read More