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    Poikilodermatous Mycosis Fungoides - Rare Entity, Different Treatment Modalities.
    Acta Dermatovenerol Croat 2018 Apr;26(1):48-52
    Prof. Romana Čeović, MD, PhD, Department of Dermatovenereology University Hospital Center Zagreb, University of Zagreb School of Medicine , Šalata 4, 10000 Zagreb, Croatia;
    Poikilodermatous mycosis fungoides (PMF) is a rare clinical variant of early-stage MF with peculiar histological features. Poikiloderma occurs in many different clinical conditions, which makes a diagnostic procedure more complicated. PMF belongs to a group of MF variants with low risk of disease progression. Read More

    Mycosis Fungoides and Vitamin D Status: Analyses of Serum 25-Hydroxyvitamin D Levels and Single Nucleotide Polymorphisms in the Vitamin D Receptor Gene.
    Acta Dermatovenerol Croat 2018 Apr;26(1):8-14
    Pinar Incel Uysal, MD, Talatpasa Bulvari, Ankara Numune Training and Research Hospital Dermatology Department, 06100, Altindag, Ankara , Turkey;
    Various types of cancer, including melanoma and non-melanoma skin cancer, are associated with vitamin D receptor (VDR) polymorphisms. However, few studies have addressed VDR polymorphisms in patients with mycosis fungoides (MF), and previous studies have reported conflicting results. Aim of this case-control study was to assess the correlation between VDR single nucleotide polymorphisms (SNPs) Cdx2, Fok1, Apa1, Bsm1, and Taq1 and MF. Read More

    Inflammatory cytokines and peripheral mediators in the pathophysiology of pruritus in cutaneous T-cell lymphoma.
    J Eur Acad Dermatol Venereol 2018 May 18. Epub 2018 May 18.
    Department of Dermatology, The University of Texas MD Anderson Cancer Center, Houston, Texas, USA.
    Cutaneous T-cell lymphoma (CTCL) includes a diverse group of neoplasms, including mycosis fungoides and Sézary syndrome. One of the earliest and most common symptoms of CTCL is pruritus, which affects up to 88% of patients. The severity of pruritus can range from mild to very debilitating, producing tremendous discomfort and a significant decrease in quality of life. Read More

    Reflectance Confocal Microscopy as New Diagnostic Tool in Folliculotropic Mycosis Fungoides.
    Skin Appendage Disord 2018 Apr 9;4(2):118-121. Epub 2017 Sep 9.
    Dermatology Unit, Department of Clinical Medicine and Surgery, University Federico II, Naples, Italy.
    We present a case of folliculotropic mycosis fungoides (FMF), a variant of cutaneous T-cell lymphoma which particularly affects hair follicles. FMF can imitate a wide variety of otherwise benign dermatoses, so it poses major diagnostic obstacles both for the dermatologist as well as the dermatopathologist. In our case, in vivo reflectance confocal microscopy (RCM) was very important for guiding the skin biopsy site selection. Read More

    Sezary syndrome manifesting as posttransplant lymphoproliferative disorder.
    Leuk Res Rep 2018 1;9:72-75. Epub 2018 May 1.
    Department of Malignant Hematology, Moffitt Cancer Center, Tampa, FL, USA.
    Posttransplant lymphoproliferative disorders (PTLDs) of T-cell orgin are rare biologically heterogeneous diseases of mature lymphoid cells manifesting in immunosuppressed patients. Only a few cases of mycosis fungoides diagnosed post allogeneic hematopoietic cell transplant (alloHSCT) have been described so far. We present a patient with myelodysplastic syndrome (MDS) post matched unrelated donor alloHSCT who was on long-term immunosuppressive therapy due to graft versus host disease. Read More

    Early morphea simulating patch-stage mycosis fungoides in two cases.
    Dermatol Reports 2018 Apr 23;10(1):7471. Epub 2018 Apr 23.
    Student Researcher Committee, Hamadan University of Medical Sciences, Hamadan, Iran.
    Morphea is a skin disorder characterized by thickening of dermis and subcutaneous tissues and loss of adnexal structures. In the early inflammatory stage of morphea, diagnostic histological findings are absent and this may lead to confusion with other inflammatory dermatoses such as mycosis fungoides (MF). We report two cases of early stage morphea mimicking patchstage of MF. Read More

    Special AT rich-binding1 protein (SATB1) in malignant T cells.
    J Invest Dermatol 2018 May 8. Epub 2018 May 8.
    Department of Immunology and Microbiology, University of Copenhagen, Copenhagen, Denmark. Electronic address:
    Deficient expression of Suppressor Special AT-rich Binding-1 (SATB1) hampers thymocyte development and results in inept T cell lineages. Recent data implicate dysregulated SATB1 expression in the pathogenesis of mycosis fungoides (MF), the most frequent variant of cutaneous T cell lymphoma (CTCL). Here we report on a disease-stage-associated decrease of SATB1 expression and an inverse expression of STAT5 and SATB1 in situ. Read More

    High-throughput sequencing of the T cell receptor β gene identifies aggressive early-stage mycosis fungoides.
    Sci Transl Med 2018 May;10(440)
    Department of Dermatology, Brigham and Women's Hospital, and the Center for Cutaneous Oncology, Dana-Farber/Brigham and Women's Cancer Center, Harvard Medical School, Boston, MA 02115, USA.
    Mycosis fungoides (MF), the most common cutaneous T cell lymphoma (CTCL) is a malignancy of skin-tropic memory T cells. Most MF cases present as early stage (stage I A/B, limited to the skin), and these patients typically have a chronic, indolent clinical course. However, a small subset of early-stage cases develop progressive and fatal disease. Read More

    Healthcare resource utilization, costs of care, and treatment of mycosis fungoides cutaneous T-cell lymphoma patterns in a large managed care population: a retrospective US claims-based analysis.
    J Dermatolog Treat 2018 May 7:1-7. Epub 2018 May 7.
    b HealthCore, Inc , Wilmington , DE , USA.
    Purpose: To evaluate health care utilization, treatment patterns and costs among patients with mycosis fungoides-cutaneous T-cell lymphoma (MF-CTCL).

    Methods: This retrospective cohort study queried the HealthCore Integrated Research Database to identify patients ≥18 years with ≥2 diagnoses of MF-CTCL (ICD-9-CM code 202.1x, 202. Read More

    Folliculotropic mycosis fungoides.
    J Dtsch Dermatol Ges 2018 May 4;16(5):543-557. Epub 2018 May 4.
    Kempf und Pfaltz, Dermatopathology Laboratory, Zurich, Switzerland.
    Accepted by the WHO and EORTC as a variant of classic mycosis fungoides, folliculotropic (syn.: follicular or pilotropic) mycosis fungoides (FMF) is characterized by a broad clinical and histological spectrum with numerous differential diagnoses. Recent studies have shown that FMF can be divided into two prognostically different subgroups, both marked by histological as well as clinical differences. Read More

    Molecular advances in cutaneous T-cell lymphoma.
    Semin Cutan Med Surg 2018 Mar;37(1):81-86
    Department of Dermatology, Leiden University Medical Center, Leiden, The Netherlands.
    Cutaneous T-cell lymphoma (CTCL) is a group of malignancies derived from skin-homing T cells. Mycosis fungoides (MF) and Sézary syndrome (SS) are the most common CTCL variants. In recent years, the genetic landscape of SS/MF has been characterized using genome-wide nextgeneration sequencing approaches. Read More

    Histopathologic approach to epidermotropic lymphocytic infiltrates.
    Semin Cutan Med Surg 2018 Mar;37(1):56-60
    Palo Alto Medical Foundation, Palo Alto, California, USA.
    Mycosis fungoides is the most common and therefore quintessential cutaneous lymphoma and is typically characterized by an epidermotropic infiltrate of atypical monoclonal CD4+ lymphocytes. Classical histopathologic findings include epidermotropism, lymphocytes with convoluted nuclear contours and surrounding perinuclear "halos," and papillary dermal fibrosis. Atypical lymphocytes may occasionally form Pautrier's microabscesses with tagging of lymphocytes along the basal keratinocytes. Read More

    Mycosis fungoides variants-clinicopathologic features, differential diagnosis, and treatment.
    Semin Cutan Med Surg 2018 Mar;37(1):11-17
    Department of Dermatology, Leiden University Medical Center, Leiden, The Netherlands.
    Mycosis fungoides (MF) is the most common type of cutaneous T-cell lymphoma, which typically presents with erythematous patches and plaques, histopathologically characterized by superficial infiltrates of small to mediumsized atypical epidermotropic T cells. Apart from this classic type of MF, many clinical and/or histopathologic variants have been described. Correct diagnosis of these MF variants is important, but may be difficult, because they may mimic a wide variety of inflammatory skin diseases. Read More

    Mycosis fungoides-clinical and histopathologic features, differential diagnosis, and treatment.
    Semin Cutan Med Surg 2018 Mar;37(1):2-10
    Research Unit Dermatopathology, Medical University of Graz, Graz, Austria.
    Mycosis fungoides (MF) is the most common type of cutaneous lymphoma. The term MF should be used only for the classical presentation of the disease characterized by the evolution of patches, plaques, and tumors or for variants showing a similar clinical course. MF is divided into 3 clinical phases: patch, plaque, and tumor stage, and the clinical course is usually protracted over years or decades. Read More

    Bullous Complex Regional Pain Syndrome: A description of the clinical and histopathologic features.
    J Cutan Pathol 2018 Apr 27. Epub 2018 Apr 27.
    Department of Dermatology, Boston University School of Medicine.
    Complex regional pain syndrome (CRPS, formerly reflex sympathetic dystrophy) is a poorly understood syndrome occurring most commonly after peripheral trauma.(1) Diagnostic features include pain, autonomic dysregulation, sensory/motor abnormalities and trophic changes involving the affected limb.(1,2) Dermatologic findings include erythema, atrophy, xerosis, erosive disease, and reticulated erythematous patches. Read More

    Oral Mycosis Fungoides: A Report of Three Cases and Review of the Literature.
    Head Neck Pathol 2018 Apr 26. Epub 2018 Apr 26.
    Louisiana State University, 1100 Florida Avenue, New Orleans, LA, 70119, USA.
    Mycosis fungoides (MF) and Sézary syndrome are clonal T-cell proliferations that exhibit skin homing and represent the majority of cutaneous T-cell lymphomas. Early MF is a diagnostic challenge as both the clinical and microscopic features often mimic benign inflammatory conditions. Oral MF is very rare and has been associated in the past with advanced disease and a poor prognosis. Read More

    Total Skin Electron Beam Therapy with Rotary Dual Technique as Palliative Treatment for Mycosis Fungoides.
    In Vivo 2018 May-Jun;32(3):517-522
    Department of Geriatrics and Gerontology, Poznan University of Medical Sciences, Poznan, Poland.
    Background/aim: The aim of the study was to retrospectively assess the efficacy and toxicity of total skin electron beam therapy (TSEBT) in patients with primary cutaneous T-cell lymphoma (MF, mycosis fungoides) at various stages of development.

    Patients And Methods: Treatment results of 40 patients with MF stage IB-III, treated between 2001 and 2015, were reviewed. Median total dose was 32 Gy, delivered to the entire skin surface. Read More

    Photodynamic therapy as an alternative treatment for mycosis fungoides: a systemic review and meta-analysis.
    G Ital Dermatol Venereol 2018 Apr 19. Epub 2018 Apr 19.
    Department of Dermatology, Inselspital, Bern University Hospital, University of Bern, Bern, Switzerland -
    Mycosis fungoides is the most common Cutaneous T cell lymphoma. Selection of appropriate treatment for mycosis fungoides is based on prognostic factors and overall clinical stage at diagnosis. In the past decade, clinical success has been reported using photodynamic therapy as an alternative target-specific therapy to treat mycosis fungoides. Read More

    A Microbiota-Dependent, STAT3-Driven Mouse Model of Cutaneous T-Cell Lymphoma.
    J Invest Dermatol 2018 May;138(5):1022-1026
    Department of Dermatology, University of California Davis, School of Medicine, Sacramento, California. Electronic address:
    In recent years, much has been learned about the molecular genetics of cutaneous T-cell lymphomas. Fanok et al. (2018) translate knowledge from systematic genomic and transcriptomic analyses to develop a mouse model that tests the hypothesis that activated STAT3 in CD4 T cells may be a driver of cutaneous T-cell lymphomas. Read More

    The First Year of the AEVD Primary Cutaneous Lymphoma Registry.
    Actas Dermosifiliogr 2018 Apr 18. Epub 2018 Apr 18.
    Servicio de Dermatología, Hospital Universitario 12 de Octubre, Institute i+12, Medical School. Universidad Complutense, ONCOCIBER, Madrid, España.
    Background And Objective: Primary cutaneous lymphomas are uncommon. This article describes the Primary Cutaneous Lymphoma Registry of the Spanish Academy of Dermatology and Venereology (AEDV) and reports on the results from the first year.

    Patients And Methods: Disease registry for patients with primary cutaneous lymphoma. Read More

    [Annular lichenoid dermatitis of youth: A case report and literature review].
    Ann Dermatol Venereol 2018 May 16;145(5):365-375. Epub 2018 Apr 16.
    Département de dermatologie, grand hôpital de Charleroi (GHDC), grand rue 3, 6000 Charleroi, Belgique.
    Background: Annular lichenoid dermatitis of youth (ALDY) is a rare form of dermatitis mainly affecting children and young people. All cases reported show a consistent clinical and histological picture. This is the first case described in the French literature. Read More

    Lymphomatoid papulosis with folliculotropism, eccrinotropism and neurotropism.
    J Cutan Pathol 2018 Apr 16. Epub 2018 Apr 16.
    Department of Dermatology, Chinese PLA General Hospital & Medical School, Beijing, China.
    The histopathological characteristics of lymphomatoid papulosis (LyP) vary. Currently, 6 subtypes have been reported, including a new subtype with perifollicular infiltration and different degrees of folliculotropism of CD30+ atypical lymphocytes, known as follicular LyP. However, LyP pathologically manifesting with folliculotropism, eccrinotropism and neurotropism has been rarely reported. Read More

    Bone marrow suppression as a complication of total skin helical tomotherapy in the treatment of mycosis fungoides.
    Radiat Oncol 2018 Apr 13;13(1):67. Epub 2018 Apr 13.
    Department of Human Oncology, University of Wisconsin, Madison, WI, USA.
    Background: Total skin electron beam therapy (TSEBT) is an effective treatment in mycosis fungoides. Total skin helical tomotherapy (TSHT) may be an alternative to TSEBT and may offer several dosimetric and treatment advantages. There are currently very few published treatment results using TSHT in place of TSEBT for treatment of mycosis fungoides. Read More

    Nonvenereal Penile Dermatoses: A Retrospective Study.
    Indian Dermatol Online J 2018 Mar-Apr;9(2):96-100
    University Clinic of Dermatology, Hospital de Santa Maria, Lisbon, Portugal.
    Context: A variety of nonvenereal diseases can affect the penis and diminish quality of life. Many present similar clinical features and a cutaneous biopsy may be necessary to clarify the diagnosis.

    Aims: To characterize nonvenereal penile dermatoses with histological confirmation in a southwestern Europe hospital during a 9-year period. Read More

    The efficacy and safety of phototherapy in geriatric patients: a retrospective study.
    An Bras Dermatol 2018 Jan-Feb;93(1):33-38
    Department of Dermatology, Faculty of Medicine, Eskisehir Osmangazi University, Eskişehir, Turkey.
    Background: While phototherapy is a well-established treatment for many dermatoses, data from the literature regarding its use in elderly patients are quite limited.

    Objective: In this study, we aimed to determine the phototherapy indications in geriatric patients and to evaluate the effectiveness and reliability of phototherapy in this group.

    Methods: This study included 95 patients of 65 years of age and older who were treated in our phototherapy unit between 2006 and 2015. Read More

    Clinically defined subgroups of mycosis fungoides display differing histopathological features at initial biopsy.
    Leuk Lymphoma 2018 Apr 4:1-9. Epub 2018 Apr 4.
    b Department of Pathology, Hematopathology Section , University Hospital Schleswig-Holstein , Kiel , Germany.
    Most patients with mycosis fungoides (MF) remain in early disease stages but some progress to tumor stage. The individual course of the disease cannot be predicted. We wanted to assess the clinical and histological characteristics of the first available biopsy. Read More

    Cutaneous Hematolymphoid and Histiocytic Proliferations in Children.
    Pediatr Dev Pathol 2018 Mar-Apr;21(2):208-251
    2 Lauren V. Ackerman Laboratory of Surgical Pathology, St. Louis Children's Hospital and Dermatopathology, Washington University Medical Center, St. Louis, Missouri.
    This article focuses on cutaneous hematopoietic neoplasms that are more likely to be encountered in the pediatric age-group and includes both lymphoproliferative and histiocytic disorders. The cutaneous hematologic disorders in children have a different epidemiologic profile to what is seen during adulthood. Although mycosis fungoides is the most frequent form of cutaneous lymphoma in adults, it is very rare in children. Read More

    The Importance of Excluding Cutaneous T-Cell Lymphomas in Patients with a Working Diagnosis of Papuloerythroderma of Ofuji: A Case Series.
    Case Rep Dermatol 2018 Jan-Apr;10(1):46-54. Epub 2018 Feb 21.
    Division of Dermatology, University of Ottawa, Ottawa, Ontario, Canada.
    Papuloerythroderma of Ofuji (PEO) is an erythroderma-like eruption with flat-topped papules that spare the skin folds (a "deck-chair sign" finding). Many infections, medications, and systemic diseases have been associated with PEO, including cutaneous T-cell lymphomas (CTCL). The relationship between the clinical presentation of PEO and CTCL remains poorly elucidated. Read More

    Folliculotropic Mycosis Fungoides in 20 Korean Cases: Clinical and Histopathologic Features and Response to Ultraviolet A-1 and/or Photodynamic Therapy.
    Ann Dermatol 2018 Apr 21;30(2):192-201. Epub 2018 Feb 21.
    Department of Dermatology, Kosin University College of Medicine, Busan, Korea.
    Background: Folliculotropic mycosis fungoides (FMF) is a variant of mycosis fungoides (MF) that is characterized clinically by variable types of skin eruptions, including plaques, acneiform lesions, and alopecic patches. Histopathologically, FMF is characterized by folliculotropic infiltrates.

    Objective: This study was conducted to scrutinize the clinical and histopathologic features of FMF in Koreans and the responses to phototherapy. Read More

    Re-infection of Toxoplasma gondii after HSCT presenting lymphadenopathy resembling recurrence of lymphoma.
    Transpl Infect Dis 2018 Mar 30:e12892. Epub 2018 Mar 30.
    Department of Hematology, Hokkaido University Hospital, Sapporo, Japan.
    Toxoplasma gondii (T. gondii) reactivation is one of the fatal complications after hematopoietic stem cell transplantation (HSCT); however, re-infection has not been reported. Here, we report a case of mycosis fungoides in which cervical lymphadenopathy developed after HSCT. Read More

    Immune privilege disruption in folliculotropic mycosis fungoides: investigation of major histocompatibility complex antigen expression.
    Int J Dermatol 2018 Jun 30;57(6):675-680. Epub 2018 Mar 30.
    Department of Dermatology, University of São Paulo Medical School, São Paulo, Brazil.
    Background: Folliculotropic mycosis fungoides (FMF) is a cutaneous T-cell lymphoma mainly affecting the hair follicle, which seems to represent a place of immune privilege phenomenon.

    Objectives: To explore a possible role of immune privilege (IP) in FMF analyzing the major histocompatibility complex (MHC) expression.

    Methods: Immunohistochemistry for HLA-G and MHC-II was performed to formalin-fixed paraffin-embedded cutaneous skin biopsies of FMF patients (n = 43), conventional mycosis fungoides (CMF; n = 13), alopecia areata (AA; n = 13), and normal scalp skin (NS; n = 12). Read More

    Systemic Treatment Options for Advanced-Stage Mycosis Fungoides and Sézary Syndrome.
    Curr Oncol Rep 2018 Mar 23;20(4):32. Epub 2018 Mar 23.
    Peter MacCallum Cancer Centre, 305 Grattan Street, Melbourne, VIC, 3000, Australia.
    Purpose Of Review: Cutaneous T-cell lymphoma (CTCL) is a rare form of non-Hodgkin lymphoma. Globally, the most common subtypes of CTCL are mycosis fungoides and Sézary syndrome. CTCL can confer significant morbidity and even mortality in advanced disease. Read More

    Erythroderma and extensive poikiloderma - a rare initial presentation of dermatomyositis: a case report.
    J Med Case Rep 2018 Mar 24;12(1):83. Epub 2018 Mar 24.
    National Hospital, Colombo, Sri Lanka.
    Background: Dermatomyositis is a humoral-mediated inflammatory myopathy with symmetrical proximal muscle weakness and dermatological manifestations such as Gottron's papules, heliotrope rash, periungual abnormalities, and flagellate erythema. Erythroderma is a severe and potentially life-threatening dermatological condition with diffuse erythema and scaling involving more than 90% of the skin surface area. Poikiloderma vasculare atrophicans refers to mottled hyperpigmentation and hypopigmentation of the skin with in-between telangiectases and areas of atrophy and is considered a variant of mycosis fungoides. Read More

    The Use of Central Pathology Review With Digital Slide Scanning in Advanced-stage Mycosis Fungoides and Sézary Syndrome: A Multi-institutional and International Pathology Study.
    Am J Surg Pathol 2018 Jun;42(6):726-734
    Dermatology, Stanford University, Palo Alto.
    This pathology PILOT study aims to define the role and feasibility of centralized pathology review in a cohort of 75 patients from different centers in the United States and Europe using digital slide scanning. The pathologic material from 75 patients who had been diagnosed with mycosis fungoides/Sézary syndrome and were clinically staged as IIb or above was retrieved from 11 participating centers. Each pathology reviewer was provided with the pathologic diagnosis (by the referring pathologist), and the following list of histopathologic criteria (presence or absence) from the initial report: epidermotropism, folliculotropism (FT), large cell transformation, syringotropism, and granulomas. Read More

    Phototherapy as a first line treatment for early stage mycosis fungoides: The results of a large retrospective analysis.
    Photodermatol Photoimmunol Photomed 2018 Mar 13. Epub 2018 Mar 13.
    Cutaneous lymphoma clinic, A.Sygros Hospital for skin diseases, National& Kapodestrian University of Athens Medical School, Athens, Greece.
    Background: Phototherapy is one of the main treatments for mycosis fungoides (MF). In this study, we analyzed the efficacy and safety of phototherapy as a first line treatment in patients with early stage disease.

    Methods: We analyzed treatment outcomes in a group of 227 early stage patients. Read More

    Successful Treatment of Erythrodermic Mycosis Fungoides with Mogamulizumab Followed by Etoposide Monotherapy.
    Case Rep Oncol 2018 Jan-Apr;11(1):29-32. Epub 2018 Jan 16.
    Department of Dermatology, Tohoku University Graduate School of Medicine, Sendai, Japan.
    Mogamulizumab induces cytotoxicity against CCR4+ lymphoma cells by antibody-dependent cell-mediated cytotoxicity in advanced cutaneous T-cell lymphoma patients. Since the efficacy of mogamulizumab in mycosis fungoides (28.6%) is lower than that in Sézary syndrome (47. Read More

    Large-Cell Transformed Mycosis Fungoides Coexisting with Mycosis Fungoides Bullosa: A Case Report and Review of the Literature.
    Case Rep Dermatol 2017 Sep-Dec;9(3):243-248. Epub 2017 Nov 27.
    Division of Dermatology, Department of Medicine, Faculty of Medicine, Ramathibodi Hospital, Mahidol University, Bangkok, Thailand.
    Mycosis fungoides is the most common form of cutaneous T-cell lymphoma. Both large-cell transformed mycosis fungoides and mycosis fungoides bullosa are rare presentations and predict unfavorable prognosis. We report the case of a 61-year-old woman who presented with generalized erythematous scaly annular plaques, and histopathology confirmed the diagnosis of mycosis fungoides. Read More

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