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Radiother Oncol 2019 Feb 31;131:88-92. Epub 2018 Dec 31.

Department of Radiation Oncology, The University of Texas MD Anderson Cancer Center, United States. Electronic address:

Background And Purpose: A lower proportion of CD8+ tumor infiltrating lymphocytes in mycosis fungoides (MF) patients is associated with worse survival. However, it is not known whether circulating CD4:CD8 ratio is a prognosticator of response to total skin electron beam therapy (TSEBT).

Methods And Materials: We identified 126 MF patients treated with TSEBT from 2001 to 20014 at two high-volume academic centers. Read More

Blood Adv 2019 Feb;3(4):519-530

Instititute of Immunology and Immunotherapy, University of Birmingham, Birmingham, United Kingdom; and.

Immunotherapy is a valuable treatment for many cancer patients, and there is considerable interest in understanding the mechanisms of immune evasion to guide appropriate management. Mycosis fungoides (MF) is a malignant disorder of skin-homing CD4 T cells, and it exhibits a highly variable clinical course during which the tumor-specific immune response may be an important determinant. An unusual feature of MF is that tumor-infiltrating lymphocytes (TILs) must attempt to control a malignant cell from within their own lineage. Read More

J Am Acad Dermatol 2019 Feb 11. Epub 2019 Feb 11.

Department of Hematology, MedStar Washington Hospital Center, 110 Irving St, Washington DC, 20010.

J Dtsch Dermatol Ges 2019 Feb;17(2):186-188

Dermatology Service, Department of Medicine, Memorial Sloan Kettering Cancer Center, and Weill Cornell Medicine, New York, NY, USA.

Int J Dermatol 2019 Feb 14. Epub 2019 Feb 14.

Division of Dermatology, Department of Medicine, Sunnybrook Health Sciences Centre, Toronto, Canada.

Background: Mycosis fungoides (MF) typically has a CD4 CD8 T-cell phenotype. Rare cases of CD4 CD8 , CD4 CD8 , or CD4 CD8 immunophenotypes have been described. Little is known about the impact of MF immunophenotypes on disease behavior. Read More

Leuk Lymphoma 2019 Feb 14:1-3. Epub 2019 Feb 14.

a Department of Radiation Oncology , Virginia, Commonwealth University Health System, Massey Cancer Center.

Clin Lymphoma Myeloma Leuk 2019 Jan 2. Epub 2019 Jan 2.

University of Arizona, Tucson, AZ.

Background: Serum copper has been reported to be increased in various cancers, including lymphoma. The purpose of the present study was to investigate the clinical and prognostic importance of serum copper levels in patients with cutaneous T-cell lymphoma (CTCL).

Patients And Methods: Serum copper was measured in 60 men and 38 women with mycosis fungoides (MF) and 14 men and 3 women with erythrodermic CTCL (6 with Sézary syndrome) consecutively evaluated from July 1980 to June 1985. Read More

JAAD Case Rep 2019 Feb 31;5(2):201-204. Epub 2019 Jan 31.

Columbia University Medical Center, Department of Dermatology, New York, New York.

J Cutan Pathol 2019 Feb 7. Epub 2019 Feb 7.

Los Angeles Medical Center (LAMC), Southern California Kaiser Permanente, Department of Dermatology, Los Angeles, California,, USA.

Introduction: Granulomatous mycosis fungoides (MF) is a rare variant in which granulomas are associated with other typical signs of MF. Its prognosis is worse than that of classical MF. Plasmacytoid dendritic cells (PDC) are a subset of Interferon (IFN) producing dendritic cells that link the innate and the adaptative immune responses. Read More

JAAD Case Rep 2019 Feb 30;5(2):180-183. Epub 2019 Jan 30.

Georgetown University School of Medicine, Department of Dermatology, Washington, DC.

J Dermatolog Treat 2019 Feb 6:1-14. Epub 2019 Feb 6.

a 1st Department of Dermatology "Andreas Syggros" Hospital, Medical School, National and Kapodistrian University of Athens , Athens , Greece.

Although anti-TNFα agents have revolutionized the treatment of many inflammatory diseases, various concerns have been reported regarding the risks of cancer development, as well as acceleration of the progression of subclinical, pre-existing malignancies. In this case series we investigated the provocative effect of anti-TNFα drugs in the development of cutaneous mycosis fungoides (MF)-like lymphoproliferative reactions. We describe 5 patients aged between 25-63 diagnosed with autoimmune disorders (psoriatic arthritis- one patient, Crohn's disease- one patient and ankylosing spondylitis- three patients) who received anti-TNFα agents before the development of a cutaneous lymphoproliferative reaction. Read More

J Am Acad Dermatol 2019 Feb 1. Epub 2019 Feb 1.

Department of Pathology, Memorial Sloan Kettering Cancer Center and Weill Cornell Medical College, New York, NY, USA.

Background: Follicular mucinosis (FM), defined by mucin accumulation within follicular epithelium, may occur in mycosis fungoides (MF). FM without MF is occasionally reported in systemic hematologic malignancies, and may be diagnostically challenging.

Objective: To describe clinicopathological characteristics of FM in patients with hematologic malignancies other than MF. Read More

Palliat Med 2019 Feb 4:269216319828189. Epub 2019 Feb 4.

4 Division of Palliative Care, Peter MacCallum Cancer Centre, Victorian Comprehensive Cancer Centre, Melbourne, VIC, Australia.

Background:: Intractable pruritus affects an estimated 83% of patients with advanced cutaneous T-cell lymphoma. Palliative care strategies to improve outcomes for these patients are lacking. Lignocaine antagonises kappa opioid antagonist-induced scratching in mice models and may relieve cutaneous T-cell lymphoma-pruritus. Read More

Ann Dermatol Venereol 2019 Jan 28. Epub 2019 Jan 28.

Service de médecine vasculaire, groupe hospitalier Paris Saint-Joseph, 185, rue Raymond-Losserand, 75014 Paris, France.

Background: Topical chlormethine has been widely used in the early stages of mycosis fungoides for many years. Cutaneous reactions (skin irritation and itch) are the most frequent adverse effects. Herein we report a rare side effect: severe necrotic leg ulcers. Read More

Zhonghua Xue Ye Xue Za Zhi 2019 Jan;40(1):77

Department of Clinical Medicine, the Affiliated Tumor Hospital of Zhengzhou University, Zhenghou 450008, China.

JAMA Dermatol 2019 Jan 30. Epub 2019 Jan 30.

Department of Dermatology, Liverpool Hospital, Liverpool, Sydney, Australia.

Importance: Phototherapy is one of the mainstays of treatment for early mycosis fungoides (MF). The most common modalities are psoralen-UV-A (PUVA) and narrowband UV-B (NBUVB).

Objective: To compare the efficacy and adverse effects of PUVA vs NBUVB in early-stage MF. Read More

Dermatol Online J 2018 Nov 15;24(11). Epub 2018 Nov 15.

Hematology Research Center, Shiraz University of Medical Sciences, Shiraz.

Hypopigmented mycosis fungoides (HMF) is an uncommon form of cutaneous T-cell lymphoma. It can be seen in children and is usually mistaken for eczema, vitiligo, or progressive macular hypomelanosis, clinically and histopathologically. We present a boy with HMF confirmed by histopathology. Read More

Chin Clin Oncol 2019 Jan 9. Epub 2019 Jan 9.

Department of Dermatology and Cutaneous Biology, Thomas Jefferson University, Philadelphia, PA, USA; Sidney Kimmel Cancer Center at Jefferson Health, Philadelphia, PA, USA.

Mycosis fungoides (MF) and Sézary syndrome (SS) are two well-characterized skin limited and leukemic subtypes of cutaneous T-cell lymphoma (CTCL), respectively. Progressive global immune dysfunction and a multitude of specific immunological abnormalities have long been recognized as features of MF and SS. Therefore, a variety of immune-based therapies have been explored and used in the clinic for decades in the attempt to restore the immune imbalance in these malignancies. Read More

Indian J Dermatol Venereol Leprol 2019 Jan 25. Epub 2019 Jan 25.

Department of Dermatology and Venereology, All India Institute of Medical Sciences, New Delhi, India.

Background: Hypopigmented macules are seen in a variety of disorders and the diagnosis rests on clinicopathological correlation. However, some cases are difficult to classify and pose a diagnostic challenge.

Aim: To describe the clinical and histopathological features of patients with hypopigmented macules and follicular spongiosis on histopathology. Read More

Case Rep Oncol 2018 Sep-Dec;11(3):850-854. Epub 2018 Dec 13.

Department of Dermatology, Tohoku University Graduate School of Medicine, Sendai, Japan.

Angioinvasive lymphomatoid papulosis (LyP) type E is a rare variant characterized by angiocentric and angiodestructive features with CD30+ CD8+ lymphocyte infiltration. In rare cases, LyP type E is concomitant with mycosis fungoides, but there is no English report that describe LyP type E developing from parapsoriasis en plaque. In this report, we described a case of angioinvasive LyP (type E) developing from parapsoriasis en plaque, in which we employed immunohistochemical staining for the investigation of its pathomechanisms. Read More

Dermatol Online J 2018 Dec 15;24(12). Epub 2018 Dec 15.

The Ronald O. Perelman Department of Dermatology, New York University Langone Health, New York, New York.

Folliculotropic mycosis fungoides (MF) is a distinct subset of cutaneous T cell lymphoma (CTCL). The disease is typically marked by an aggressive course and is often recalcitrant to skin-direct therapy. We report a case of an 83-year-old woman with folliculotropic MF characterized by erythematous, scaly plaques on the forehead along with poliosis and alopecia of the right medial eyebrow. Read More

Dermatol Ther 2019 Jan 19:e12835. Epub 2019 Jan 19.

Department of Dermatology, University of Minnesota, Moffitt Cancer Center, Tampa, Florida.

Brentuximab vedotin is a CD30-antibody/drug conjugate which has demonstrated excellent response in treating CD30-positive mycosis fungoides (MF) and anaplastic large cell lymphoma (ALCL). In this report, we present a patient with CD30-negative MF refractory to multiple other lines of therapy who demonstrated a dramatic response to brentuximab. This paradoxical response may be due to inadequate detection of CD30 expression by immunohistochemical techniques. Read More

Pediatr Dermatol 2019 Jan 18. Epub 2019 Jan 18.

Department of Dermatology, Northwestern University, Feinberg School of Medicine, Chicago, Illinois.

We described the development of multiple melanocytic nevi within long-standing MF patches in four young patients. Mycosis fungoides (MF) patches are characterized by a regulatory-like cytokine profile leading to local immune suppression. The proliferation of nevomelanocytes is regulated by cellular senescence mechanisms mediated by immune system. Read More

Australas J Dermatol 2019 Jan 17. Epub 2019 Jan 17.

South East Dermatology Stafford, Stafford, Queensland, Australia.

J Eur Acad Dermatol Venereol 2019 Jan 17. Epub 2019 Jan 17.

Department of Dermatology, Saint-Louis Hospital, APHP, Paris Diderot University, INSERM U976, Paris, France.

Mycosis fungoides (MF), the most frequent type of cutaneous T-cell lymphoma, is characterized in the early stage by patches and plaques that predominate in sun-protected areas. MF is rarely associated with vulvar involvement. We report two cases of MF with predominant vulvar lesions. Read More

Acta Derm Venereol 2019 01 17. Epub 2019 Jan 17.

Department of Dermatology, INSERM U1058 University of Montpellier, FR-34295 Montpellier, France.

Optimal doses of total skin electron beam therapy for mycosis fungoides remain to be established. Clinical efficiency and adverse effects of middle-dose (25 Gy) vs. low-dose (10-12 Gy) total skin electron beam therapy were retrospectively compared in a series of 14 and 12 mycosis fungoides, respectively. Read More

Actas Dermosifiliogr 2019 Jan 11. Epub 2019 Jan 11.

Instituto Nacional de Cancerología, Bogotá, Colombia.

Zhonghua Bing Li Xue Za Zhi 2019 Jan;48(1):11-16

Department of Pathology, Fujian Cancer Hospital, Fujian Medical University Cancer Hospital, Fuzhou 350014, China.

To investigate the clinical presentation, clinicopathologic features, diagnosis and differential diagnosis of adult T cell leukemia/lymphoma (ATLL). Four cases of ATLL from Fujian Cancer Hospital between October 2017 and May 2018 were analyzed using hematoxylin-eosin and immunohistochemical stains and polymerase chain reaction (PCR) for HTLV-1 provirus genes. The relevant literature was reviewed. Read More

Leuk Lymphoma 2019 Jan 11:1-3. Epub 2019 Jan 11.

a Department of Medicine , Lymphoma Service, Memorial Sloan Kettering Cancer Center , New York , NY , USA.

JCI Insight 2019 Jan 10;4(1). Epub 2019 Jan 10.

Department of Dermatology, Brigham and Women's Hospital, Harvard Medical School, Boston, Massachusetts, USA.

Psoralen plus UVA (PUVA) is an effective therapy for mycosis fungoides (MF), the skin-limited variant of cutaneous T cell lymphoma (CTCL). In low-burden patients, PUVA reduced or eradicated malignant T cells and induced clonal expansion of CD8+ T cells associated with malignant T cell depletion. High-burden patients appeared to clinically improve but large numbers of malignant T cells persisted in skin. Read More

J Med Internet Res 2019 Jan 7;21(1):e11302. Epub 2019 Jan 7.

PatientsLikeMe, Inc, Cambridge, MA, United States.

Background: Although the quality of life (QoL) plays an important role in treatment decision making and clinical management of mycosis fungoides (MF) or Sézary syndrome (SS) subtypes of cutaneous T-cell lymphomas (MF/SS-CTCLs), an MF- or SS-specific measure of QoL does not exist.

Objective: The objective of this research was to develop and validate the first QoL instrument for MF/SS-CTCL using a patient-centered approach.

Methods: A conceptual framework for the MF/SS-CTCL QoL was developed through a literature review and interviews with key opinion leaders. Read More

Br J Dermatol 2019 Jan 3. Epub 2019 Jan 3.

Dermatology Service, Department of Medicine, Memorial Sloan Kettering Cancer Center and Weill Cornell Medicine, New York, NY, U.S.A.

Br J Dermatol 2019 Jan 3. Epub 2019 Jan 3.

Leiden University Medical Centre, Leiden, the Netherlands.

Int J Dermatol 2019 Jan 3. Epub 2019 Jan 3.

Department of Dermatology, Consorcio Hospital General Universitario de Valencia, Valencia, Spain.

J Allergy Clin Immunol Pract 2019 Jan;7(1):28-33

Departments of Dermatology, Preventive Medicine and Medical Social Sciences, Feinberg School of Medicine at Northwestern University, Chicago, Ill; Northwestern Medicine Multidisciplinary Eczema Center, Chicago, Ill. Electronic address:

One in 4 adults with atopic dermatitis (AD) report adult-onset disease. Adult-onset AD appears to be associated with a different disease phenotype compared with childhood-onset AD. A broad differential diagnosis must be considered in a patient presenting with an adult-onset eczematous eruption, including allergic contact dermatitis, mycosis fungoides/cutaneous T-cell lymphoma, psoriasis, scabies, and so forth. Read More

Histopathology 2018 Dec 31. Epub 2018 Dec 31.

Department of Pathology, University of Michigan, Ann Arbor, MI.

Aims: Histopathologic overlap between lupus erythematosus and certain types of cutaneous T-cell lymphoma (CTCL) is well documented. CD123+ plasmacytoid dendritic cells (PDCs) are typically increased in lupus erythematosus, but have not been well studied in CTCL. We aimed to compare CD123 immunostaining and histopathologic features in these conditions. Read More

Cancer Treat Res 2019 ;176:249-268

Division of Dermatology, City of Hope National Medical Center, Duarte, CA, USA.

Primary cutaneous CD30-positive lymphoproliferative disorders (CD30+ LPD) encompass lymphomatoid papulosis (LyP), primary cutaneous anaplastic large cell lymphoma (pcALCL), and borderline lesions [1]. CD30+ LPD are the second most common cutaneous T-cell lymphomas (CTCL) after mycosis fungoides (MF) and represent approximately 25% of all CTCL cases [2]. Their common phenotypic hallmark is an expression of the CD30 antigen, a cytokine receptor belonging to the tumor necrosis factor (TNF) receptor superfamily. Read More

Cancer Treat Res 2019 ;176:225-248

Department of Hematology/Hematopoietic Cell Transplantation, Duarte, USA.

Mycosis fungoides and Sézary syndrome are the most common subtypes of all primary cutaneous lymphomas and represent complex diseases that require a multidisciplinary assessment by dermatologists, oncologists, and pathologists. Staging and work-up are critical to guarantee an optimal treatment plan that includes skin-directed and/or systemic regimens depending on the clinical stage, tumor burden, drug-related side effect profile, and patient comorbidities. However, there is no cure and patients frequently relapse, requiring repeated treatment courses for disease control. Read More

Cancer Treat Res 2019 ;176:31-68

Department of Pathology, City of Hope National Medical Center, Duarte, CA, USA.

Peripheral T-cell lymphoma (PTCL) is an uncommon group of lymphoma covering a diverse spectrum of entities. Little was known regarding the molecular and genomic landscapes of these diseases until recently but the knowledge is still quite spotty with many rarer types of PTCL remain largely unexplored. In this chapter, the recent findings from gene expression profiling (GEP) studies, including profiling data on microRNA, where available, will be presented with emphasis on the implication on molecular diagnosis, prognostication, and the identification of new entities (PTCL-GATA3 and PTCL-TBX21) in the PTCL-NOS group. Read More

Eur J Dermatol 2018 Dec;28(6):764-774

Department of Dermatology, UT Southwestern Medical Center, Dallas, TX, USA.

The efficacy of alemtuzumab for the treatment of refractory Sézary syndrome (SS) versus other third-line agents such as pralatrexate and gemcitabine is poorly characterized. To elucidate the effectiveness of alemtuzumab versus other third-line options for the treatment of refractory SS, we conducted a meta-analysis of existing data. A systematic review was performed in March 2017 based on a search using Ovid-MEDLINE and OVID-EMBASE for articles evaluating single-agent alemtuzumab, gemcitabine, or pralatrexate for the treatment of SS and mycosis fungoides (MF). Read More

Clin Nucl Med 2019 Mar;44(3):244-245

From the Departments of Dermatology and.

A 34-year-old Japanese woman presented with widespread scaly erythema that had enlarged over 2 years. A skin biopsy revealed the diagnosis of mycosis fungoides (patch stage, T1b N0 M0 B0), a most frequent cutaneous T-cell lymphoma. F-FDG PET/CT scan unexpectedly showed intense uptake on the left sole, which suggested a tumorous mycosis fungoides lesion (SUVmax = 6. Read More

Dermatol Ther 2018 Dec 27:e12807. Epub 2018 Dec 27.

Department of Dermatology, Peking Union Medical College Hospital, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing, China.

To explore and compare the clinical presentations and pathologic features of cutaneous pseudolymphomas (CPL) with primary cutaneous lymphomas. Review literature in order to improve the treatment of CPL. Six cases of CPLs were collected. Read More

Clin Transl Radiat Oncol 2019 Feb 6;15:26-30. Epub 2018 Dec 6.

National Kapodistrian University of Athens, Medical School, 2nd Dpt Radiology, Radiotherapy Unit, ATTIKON University Hospital, Athens, Greece.

Background & Purpose: Although rare, cutaneous lymphomas represent a separate entity in hematologic oncology. T cell origin lymphomas are most common, with Mycosis Fungoides (MF) accounting for about 50-70% of cases. Sezary Syndrome (SS), which represents the leukemic varian of MF, accounts for 3% of Cutaneous T Cell Lymphomas (CTCL). Read More

JAAD Case Rep 2019 Jan 15;5(1):104-107. Epub 2018 Dec 15.

Section of Dermatology, Department of Medical Science and Public Health, University of Cagliari, Cagliari, Italy.

Case Rep Dermatol Med 2018 19;2018:5235246. Epub 2018 Nov 19.

Department of Dermatology, University of Texas McGovern Medical School at Houston, Houston, TX, USA.

Mycosis fungoides (MF) is a rare cutaneous T-cell lymphoma (CTCL) which can cause significant morbidity. During the disease course, it classically will progress through three clinical stages in the skin: patch-, plaque-, and tumor-stage. The early stages exhibit various histopathological mimics that often lead to misdiagnosis. Read More

Ann Diagn Pathol 2019 Feb 27;38:99-105. Epub 2018 Oct 27.

Department of Pathology, Dartmouth-Hitchcock Medical Center, Lebanon, NH, USA.

T cell lymphoproliferative disorders that arise in the skin are mainly derived from post thymic T cells most commonly of CD4 subset. Human CD4 positive T cells are dynamic exhibiting phenotypic and functional malleability. For example, with repetitive antigen exposure most commonly associated with age, CD4 positive T cells acquire a cytotoxic phenotype. Read More

Br J Dermatol 2018 Dec 18. Epub 2018 Dec 18.

Department of Dermatology, University of Zurich, University Hospital Zurich, Zurich, Switzerland.

Mycosis fungoides is a primary cutaneous T-cell lymphoma with unfavorable prognosis for the advanced stages of the disease. Refractory disease and advanced-stage disease require systemic therapy. We report on a rare case of an atypical predominantly CD8+ folliculotropic mycosis fungoides (MF), a subtype of MF with poorer prognosis, in a 59-year-old woman, initially diagnosed with MF restricted to the skin- of T3N0M0B0/stage IIB according to the current WHO/EORTC classification. Read More

J Cutan Pathol 2019 Mar 4;46(3):199-203. Epub 2019 Jan 4.

Department of Pathology, Michigan Medicine, Ann Arbor, Michigan.

Merkel cell carcinoma (MCC) is a rare, aggressive cutaneous neuroendocrine carcinoma with increased prevalence in patients with immunosuppression or B-cell neoplasms. To the best of our knowledge, an association with cutaneous T-cell lymphoma (CTCL) has not been previously described. In this report, we present two cases of MCC arising in the setting of CTCL. Read More

Br J Dermatol 2018 Dec 18. Epub 2018 Dec 18.

Dermatology Unit, Department of Experimental, Diagnostic and Speciality Medicine, University of Bologna, Via Massarenti 1, Bologna, Italy.

J Dtsch Dermatol Ges 2019 Feb 14;17(2):186-188. Epub 2018 Dec 14.

Dermatology Service, Department of Medicine, Memorial Sloan Kettering Cancer Center, and Weill Cornell Medicine, New York, NY, USA.