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    1 OF 130

    Multiple skin cancers in patients with mycosis fungoides after long-term ultraviolet phototherapy.
    Clin Exp Dermatol 2017 May 22. Epub 2017 May 22.
    Department of Dermatology, Hokkaido University Graduate School of Medicine, Sapporo, Japan.
    Phototherapy is a useful noninvasive therapy, but it can induce cutaneous malignant tumours, including squamous cell carcinoma (SCC) and basal cell carcinoma (BCC). We report on a 79-year-old man who had long-standing mycosis fungoides for 40 years, which had been treated with psoralen ultraviolet A therapy for 37 years at a dose of approximately 5000 J/cm(2) . Approximately 6 years before presentation, numerous types of cutaneous malignancies, including actinic keratosis, BCC and SCC, had begun to develop all over the patient's body. Read More

    Multidisciplinary Management of Mycosis Fungoides/Sézary Syndrome.
    Curr Hematol Malig Rep 2017 May 24. Epub 2017 May 24.
    Penn Cutaneous Lymphoma Program, Department of Dermatology, Perelman Center for Advanced Medicine, Perelman School of Medicine at the University of Pennsylvania, 1st Floor South Pavilion, 3400 Civic Center Boulevard, Philadelphia, PA, 19104, USA.
    Purpose Of Review: Diagnosis and management of mycosis fungoides and Sézary syndrome (MF/SS) require accurate clinicopathological correlation and a multidisciplinary approach. We reviewed major advances in the field regarding diagnostic and prognostic tools as well as skin-directed therapies (SDTs) and systemic agents for MF/SS published in the past 2 years.

    Recent Findings: Improved technology (T-cell receptor high-throughput sequencing) and increased multicenter collaboration (Cutaneous Lymphoma International Consortium) have led to diagnostic/prognostic advances. Read More

    Psoriasis mimicking mycosis fungoides clinically.
    Dermatol Online J 2017 May 15;23(5). Epub 2017 May 15.
    Creighton University School of Medicine, Omaha, Nebraska.
    Psoriasis is a complex, chronic immune-mediated inflammatory disease that most commonly presents as well-demarcated erythematous plaques with micaceous scale, affecting roughly 3-4% of the US population [1-4]. Clinically, lesions are often well demarcated thick, scaly, erythematous plaques, characteristically located on the extensor surfaces, such as elbows and knees [1]. In most cases, clinical impression is sufficient to diagnose psoriasis. Read More

    Transformation of Mycosis fungoides/Sezary syndrome: clinical characteristics and prognosis.
    Turk J Haematol 2017 May 23. Epub 2017 May 23.
    Introduction: Transformed mycosis fungoides (T-MF) is a rare variant of mycosis fungoides (MF) with an aggressive course.

    Objectives: In this study we aimed to describe characteristics MF/Sezary syndrome (SS) cases with transformation.

    Materials And Methods: Patients diagnosed with transformed MF (T-MF) among MF/SS patients between 2000 and 2014 in a single center are evaluated retrospectively. Read More

    Harefuah 2016 Oct;155(10):613-615
    The Department of Dermatology, Haemek Medical Center, Afula, Israel.
    Introduction: Unilesional mycosis fungoides is a rare cutaneous T cell lymphoma that warrants either radiation therapy or surgical excision. Benign characteristics result in misdiagnosis, delayed tissue biopsy and subsequently delayed provision of adequate treatment. A young patient presented with a history of 18 months of eczematous benign - appearing single lesion restricted to her index finger. Read More

    Gelling Your Dermatology Nursing Practice: A Practical Guide for Managing the Treatment of Mycosis Fungoides Cutaneous T-Cell Lymphoma With Mechlorethamine Gel.
    J Dermatol Nurses Assoc 2016 May 9;8(3):180-192. Epub 2016 Jun 9.
    Department of Dermatology, University of Pittsburgh Medical Center, Pittsburgh, PA.
    Mycosis fungoides is the most common form of cutaneous T-cell lymphoma. Stage IA and IB mycosis fungoides cutaneous T-cell lymphoma can be effectively controlled by skin-directed therapies such as the mechlorethamine gel approved by the Food and Drug Administration. Dermatology nurses play a key role in promoting good patient compliance through patient education about mycosis fungoides cutaneous T-cell lymphoma disease, proper administration of mechlorethamine gel, and connecting patients with patient assistance programs or other supportive services. Read More

    Clinical characteristics, risk factors and long-term outcome of 114 patients with folliculotropic mycosis fungoides.
    Arch Dermatol Res 2017 May 17. Epub 2017 May 17.
    Department of Dermatology, MD Anderson Cancer Center, The University of Texas, 1515 Holcombe Blvd, Houston, TX, 77030-4095, USA.
    Folliculotropic mycosis fungoides (FMF) is a distinct variant of mycosis fungoides (MF) where atypical T-cells invade the hair follicles. The objective was to assess the clinical features, risk factors for progression, long-term outcome and response to treatment modalities in a large cohort of FMF patients. We, therefore, conducted a single-center retrospective study, reviewing 114 patients with FMF seen from 1987 to 2015 at the cutaneous T-cell lymphoma clinic of the MD Anderson Cancer Center. Read More

    Successful Treatment of Primary Cutaneous Peripheral T-Cell Lymphoma Presenting Acquired Ichthyosis with Oral Bexarotene Monotherapy.
    Case Rep Oncol 2017 Jan-Apr;10(1):328-332. Epub 2017 Apr 6.
    Department of Dermatology, Tohoku University Graduate School of Medicine, Sendai, Japan.
    Acquired ichthyosis (AI) is a reactive cutaneous manifestation that can be associated with malignant hematological disease, including cutaneous T-cell lymphoma (CTCL). Since it is difficult to distinguish AI from ichthyosiform mycosis fungoides, to select the treatment for CTCL with ichthyosis-like appearance and to evaluate its efficacy is sometimes challenging. In this report, we describe a case of primary cutaneous peripheral T-cell lymphoma not otherwise specified presenting AI successfully treated with oral bexarotene. Read More

    Concomitant B Hairy Cell Leukemia and Mycosis Fungoides in an Elderly Man.
    Case Rep Dermatol 2017 Jan-Apr;9(1):103-107. Epub 2017 Apr 7.
    aDivision of Dermatology, Department of Medicine, University of Alberta, Edmonton, Alberta, Canada.
    The development of both a T- and B-cell lymphoproliferative disorder in one patient is an unlikely coincidence due to the low prevalence of each malignancy. We report a 65-year-old man with a previously documented history of B hairy cell leukemia, who presented with a new-onset acneiform eruption of his scalp, face, trunk, back, and extremities. Routine pathology of the skin lesions with immunohistochemical stains and molecular studies were consistent with a folliculotropic mycosis fungoides. Read More

    Computed Tomography scanning in mycosis fungoides - optimising the balance between benefit and harm.
    Br J Dermatol 2017 May 12. Epub 2017 May 12.
    Department of Dermatology, University Hospitals Birmingham, Mindelsohn Way, Edgbaston, Birmingham, B15 2GW.
    Mycosis fungoides (MF) is the most common form of cutaneous T-cell lymphoma (CTCL), accounting for 55% cases(1) . Although incurable, it most often presents in early-stage with a good prognosis. The primary aim is to minimise symptoms and maximise quality of life. Read More

    Disseminated CD8-positive, CD30-positive cutaneous lymphoproliferative eruption with overlapping features of mycosis fungoides and primary cutaneous anaplastic large cell lymphoma following remote solitary lesional presentation.
    J Cutan Pathol 2017 May 12. Epub 2017 May 12.
    University of Iowa Hospitals and Clinics, Departments of Dermatology and Pathology, 200 Hawkins Drive, Iowa City, IA, 52242.
    CD8-positive, CD30-positive cutaneous lymphoproliferative disorders comprise a rare subset of T-cell lymphoproliferative conditions, including variants of primary cutaneous anaplastic large cell lymphoma, mycosis fungoides, lymphomatoid papulosis type D, cutaneous gamma-delta T-cell lymphoma, and cutaneous peripheral T-cell lymphoma. These entities share overlapping clinical, histopathologic, and immunophenotypic features, presenting both a clinical and pathological diagnostic challenge. Presented here is a 73-year-old man with a disseminated, indolent CD30+, CD8+ cutaneous lymphoproliferative disorder with overlapping clinical and histopathological features of both mycosis fungoides and primary cutaneous anaplastic large cell lymphoma, as well as features of lymphomatoid papulosis. Read More

    Clinical applications of 3-dimensional printing in radiation therapy.
    Med Dosim 2017 Summer;42(2):150-155. Epub 2017 May 8.
    Department of Medical Physics, Dalhousie University, Queen Elizabeth II Health Sciences Centre, 5820 University Avenue, Halifax, Nova Scotia B3H 2Y9, Canada.
    Three-dimensional (3D) printing is suitable for the fabrication of complex radiotherapy bolus. Although investigated from dosimetric and feasibility standpoints, there are few reports to date of its use for actual patient treatment. This study illustrates the versatile applications of 3D printing in clinical radiation oncology through a selection of patient cases, namely, to create bolus for photon and modulated electron radiotherapy (MERT), as well as applicators for surface high-dose rate (HDR) brachytherapy. Read More

    Comprehensive analysis of cutaneous T-cell lymphoma (CTCL) incidence and mortality in Canada reveals changing trends and geographic clustering for this malignancy.
    Cancer 2017 May 10. Epub 2017 May 10.
    Division of Dermatology, University of Ottawa, Ottawa, Ontario, Canada.
    Background: Previous reports of geographic clustering of cutaneous T-cell lymphoma (CTCL) in Texas, Pittsburgh, and Sweden as well as the occurrence of CTCL in married couples and family members raise a possibility of the existence of an external and potentially preventable trigger(s) for this rare skin cancer.

    Methods: The authors studied CTCL incidence and mortality in Canada using 3 distinct population-based cancer databases. Data on patients' sex, age at the time of diagnosis, subtype of CTCL malignancy, reporting province, city, and postal code were analyzed. Read More

    Cutaneous Pseudolymphoma.
    Surg Pathol Clin 2017 Jun 22;10(2):455-476. Epub 2017 Mar 22.
    Kempf & Pfaltz, Histologische Diagnostik, Seminarstrasse 1, 8057 Zürich, Zurich, Switzerland; Department of Dermatology, University Hospital Zurich, Gloriastrassse 31, 8091 Zürich, Switzerland.
    The term, cutaneous pseudolymphoma (PSL), refers to a group of lymphocyte-rich infiltrates, which either clinically and/or histologically simulate cutaneous lymphomas. Clinicopathologic correlation is essential to achieve the final diagnosis in cutaneous PSL and to differentiate it from cutaneous lymphomas. A wide range of causative agents (eg, Borrelia, injections, tattoo, and arthropod bite) has been described. Read More

    Cutaneous Lymphomas with Cytotoxic Phenotype.
    Surg Pathol Clin 2017 Jun 28;10(2):409-427. Epub 2017 Mar 28.
    Dermatopathology Laboratory, St John's Institute of Dermatology, St Thomas' Hospital, South Wing, Staircase C, Westminster Bridge Road, London SE1 7EH, UK. Electronic address:
    Primary cutaneous cytotoxic lymphomas are T-cell or natural killer-cell lymphomas that express 1 or more cytotoxic markers. These neoplasms constitute a spectrum of diseases. In this review, an overview of clinical, morphologic, and phenotypical features of each subtype is provided. Read More

    Annular Lichenoid Dermatitis (of Youth): Report of a Case With Lichen Planus-Like Features.
    Am J Dermatopathol 2017 Apr 25. Epub 2017 Apr 25.
    Department of Anatomic Pathology, Azienda Ospedaliero-Universitaria Policlinico, Modena, Italy.
    Annular lichenoid dermatitis of youth (ALDY), a dermatosis with peculiar clinical and pathological features, represents still a debated entity, given its similarity, among others, with mycosis fungoides. A case of ALDY in a 50-year-old male patient is reported. Clinically, the patient presented an oval scleroderma-like plaque on the right flank. Read More

    Allogeneic hematopoietic stem cell transplantation for refractory mycosis fungoides (MF) and Sezary syndrome (SS).
    Int J Hematol 2017 May 2. Epub 2017 May 2.
    BMT Unit, Department of Hematology, Cebeci Hospital, School of Medicine, Ankara University, Dikimevi, 06590, Ankara, Turkey.
    Cutaneous T cell lymphoma is a heterogeneous group of lymphoproliferative disorders with different clinical behavior and prognosis in which malignant T cells accumulate in the skin. In the relapsed/refractory stage, treatment strategy varies depending on clinical perspective. We retrospectively evaluated advanced stage relapse or refractory mycosis fungoides and Sezary syndrome patients who underwent allogeneic hematopoietic stem cell transplantation (allo-HSCT) at our hospital. Read More

    Total Skin Electron Beam Therapy as Part of Multimodal Treatment Strategies for Primary Cutaneous T-Cell Lymphoma.
    Oncol Res Treat 2017 25;40(5):244-252. Epub 2017 Apr 25.
    Total-skin electron beam therapy (TSEBT) is one of most effective treatments that has been used for cutaneous T-cell lymphoma. Low-dose TSEBT regimens (10-12 Gy) appear to be an effective alternative to conventional-dose TSEBT (30-36 Gy), yielding short-term remission of cutaneous manifestations with minimal toxicity. TSEBT can be administered to patients any time after a diagnosis of mycosis fungoides (MF). Read More

    No Viral Transcripts Associated with Folliculotropic Mycosis Fungoides Using a High Throughput Sequencing Approach.
    Acta Derm Venereol 2017 Apr 27. Epub 2017 Apr 27.
    Department of Dermatology, Montpellier University Hospital, Hôpital Saint-Eloi, 80 avenue Augustin Fliche, FR-34295 Montpellier, France.

    Forodesine in the treatment of cutaneous T-cell lymphoma.
    Expert Opin Investig Drugs 2017 Jun 5;26(6):771-775. Epub 2017 May 5.
    b Department of Dermatology , The University of Texas MD Anderson Cancer Center , Houston , TX , USA.
    Introduction: Cutaneous T-cell lymphoma (CTCL) is characterized by the accumulation of neoplastic CD4+ T lymphocytes in the skin. Given the lack of curative treatments for CTCL, there is a significant need for new, superior therapies. Forodesine is a transition-state analogue that inhibits purine nucleoside phosphorylase. Read More

    Ultraviolet A1 Phototherapy in the Treatment of Early Mycosis Fungoides.
    Dermatology 2017 Apr 26. Epub 2017 Apr 26.
    Department of Dermatology, Faculty of Medicine, Gazi University, Ankara, Turkey.
    Background: Phototherapy has been the mainstay of therapies for early mycosis fungoides (MF). The beneficial role of ultraviolet (UV) light on MF is suggested by the observation that lesions occur on non-sun-exposed areas. Therapeutic light sources that are available today are broadband UVB, psoralen and UVA, narrowband UVB, and long-wave UV (UVA1). Read More

    CD4-Positive T-Cell Large Granular Lymphocytosis Mimicking Sezary Syndrome in a Patient With Mycosis Fungoides.
    Cancer Control 2017 Apr;24(2):207-212
    Hematopathology & Laboratory Medicine Program, Moffitt Cancer Center, Tampa, FL.
    A white woman aged 65 years presented with a macular, nonscaly, nonpruritic, erythematous lesion on her right breast. Test results revealed histological features similar to lichenoid dermatitis and early-phase primary cutaneous T-cell lymphoma with a subtype of mycosis fungoides (MF). Despite topical therapy with steroids, her skin disease continued to progress, so she underwent polymerase chain reaction and gene mutation testing. Read More

    The role of macrophages in the pathogenesis of mycosis fungoides.
    Clin Exp Dermatol 2017 Apr 24. Epub 2017 Apr 24.
    Department of Dermatology, Kirikkale University Faculty of Medicine, Kirikkale, Turkey.
    Background: Macrophages are classified into classically activated (M1) and alternatively activated (M2) macrophages. Decrease in macrophage number in tumour tissue with treatment has been reported.

    Aim: The aim of this study was to determine whether treatment has an effect on the number of dermal M1 and M2 macrophages in patients with mycosis fungoides (MF). Read More

    ALK Expression is a Rare Finding in Mycosis Fungoides.
    Am J Dermatopathol 2017 May;39(5):342-343
    *Department of Dermatology, University of Chicago Hospital Medical Center, CA, IL; and †Department of Pathology, Southern Permanente Medical Group, LA, CA.
    Mycosis fungoides (MF) is the most common form of cutaneous T-cell lymphoma. Although indolent in its early stages, MF is more aggressive in advanced stages, particularly if large cell transformation occurs. Histologically, transformed MF is similar to primary cutaneous anaplastic large cell lymphoma (pcALCL) and nodal ALCL (nALCL). Read More

    Innovative Treatment Concepts for Cutaneous T-Cell Lymphoma Based on Microenvironment Modulation.
    Oncol Res Treat 2017 20;40(5):262-269. Epub 2017 Apr 20.
    Cutaneous T-cell lymphomas (CTCL) are a rare and biologically heterogeneous malignant entity comprising mycosis fungoides and Sézary syndrome as the most common subtypes. The current treatment outcome is characterized by high rates of relapse, but survival is usually not significantly shortened in low-stage disease. This is different in tumor-stage disease or aggressive CTCL subtypes where survival is significantly reduced. Read More

    The IL-31/IL-31 receptor axis: general features and role in tumor microenvironment.
    J Leukoc Biol 2017 Apr 13. Epub 2017 Apr 13.
    Immunology Area, Ospedale Pediatrico Bambino Gesù, Roma, Italy
    IL-31 is a recently identified cytokine with a well-defined role in the pathogenesis of pruritus. IL-31, whose production is induced by IL-4 and IL-33, binds a heterodimeric receptor (R) composed of the exclusive IL-31RA chain and the shared oncostatin M R. Signaling through the IL-31R involves the MAPK, PI3K/AKT and Jak/STAT pathways. Read More

    Biological and clinical significance of tryptophan-catabolizing enzymes in cutaneous T-cell lymphomas.
    Oncoimmunology 2017 10;6(3):e1273310. Epub 2017 Feb 10.
    Department of Dermatology and Allergology, University of Helsinki and Helsinki University Central Hospital , Helsinki, Finland.
    Indoleamine 2,3-deoxygenase 1 (IDO1) induces immune tolerance in the tumor microenvironment (TME) and is recognized as a potential therapeutic target. We studied the expression of both IDO1 and the related tryptophan 2,3-dioxygenase (TDO) in several different subtypes of cutaneous T-cell lymphoma (CTCL), and evaluated the kynurenine (KYN) pathway in the local TME and in patient sera. Specimens from the total of 90 CTCL patients, including mycosis fungoides (MF, n = 37), lymphomatoid papulosis (LyP, n = 36), primary cutaneous anaplastic large cell lymphoma (pcALCL, n = 4), subcutaneous panniculitis-like T-cell lymphoma (SPTCL n = 13), and 10 patients with inflammatory lichen ruber planus (LRP), were analyzed by immunohistochemistry (IHC), immunofluorescence (IF), quantitative PCR, and/or liquid chromatography-tandem mass spectrometry (LC-MS/MS). Read More

    Hypopigmented Mycosis Fungoides: Clinical, Histological, and Immunohistochemical Remission Induced by Narrow-band Ultraviolet B.
    Indian J Dermatol 2017 Mar-Apr;62(2):203-206
    Department of Pathology, University College of Medical Sciences and GTB Hospital, University of Delhi, New Delhi, India.
    Mycosis fungoides (MF) is the most common type of primary cutaneous lymphomas. Several clinical variants of MF have been described. Purely, hypopigmented variant of MF (HMF) is rare. Read More

    CD3+, CD56+, CD4-, CD8-, CD20-, CD30- Peripheral T-Cell Non-Hodgkin's Lymphoma: A Rare Case Report.
    Indian J Dermatol 2017 Mar-Apr;62(2):200-202
    Department of Skin and VD, B.J. Medical College and Civil Hospital, Ahmedabad, Gujarat, India.
    Cutaneous T-cell lymphoma (CTCL) commonly presents as mycosis fungoides or Sezary syndrome, both having CD4 positivity. A subset of CTCL which lacks CD4 surface marker is classified as cutaneous γ and δ-T-cell lymphoma (CGD-TCL). Because of its rarity and inability to study large number of patients, the impact of immunophenotype on the clinical outcome of primary CTCL in patients is limited. Read More

    Oral and Cutaneous Lymphomas other than Mycosis Fungoides and Sézary Syndrome in a Mexican Cohort: Recategorization and Evaluation of International Geographical Disparities.
    Indian J Dermatol 2017 Mar-Apr;62(2):158-167
    Department of Pathology, Instituto Nacional de Ciencias Médicas y Nutrición Salvador Zubirán, City, Mexico; Division of Pathology, Instituto Nacional de Cancerología, Mexico City, Mexico.
    Background: Nonmycosis fungoides/Sézary syndrome (non-MF/SS) primary cutaneous lymphomas (PCL) are currently categorized under the 2005-World Health Organization/European Organization for Research and Treatment of Cancer (WHO-EORTC) classification for PCL. These differ in behavior from secondary cutaneous lymphomas (SCL) and to lymphomas limited to the oral cavity (primary oral lymphomas [POL]) both categorized under the 2016-WHO classification for lymphoid neoplasms.

    Aims: This study aims to report the first series of non-MF/SS PCL, SCL, and POL in a Mexican cohort, examine the applicability of current classification systems and compare our findings with those from foreign cohorts. Read More

    New Targeted Treatments for Cutaneous T-cell Lymphomas.
    Indian J Dermatol 2017 Mar-Apr;62(2):142-145
    Department of Dermatology, University Paris 7, Hopital Saint-Louis, Paris, France.
    Cutaneous T-cell lymphomas (CTCLs) represent a group of rare and heterogeneous diseases that are very difficult to treat at advanced stages. The development of monoclonal antibodies is a new hope for the treatment of these diseases. Alemtuzumab (Campath) is a humanized IgG1 kappa monoclonal antibody specific for CD52, an antigen expressed by most T and B lymphocytes. Read More

    Management Strategies for Mycosis Fungoides in India.
    Indian J Dermatol 2017 Mar-Apr;62(2):137-141
    Department of Dermatology, Tata Medical Centre, Kolkata, West Bengal, India.
    Mycosis fungoides is the most common primary cutaneous T-cell lymphoma. The approach to diagnosis and further follow-up is outlined. Evidence for interventions is based classically on a Tumor Node Metastasis Blood TNMB "stage-based" approach. Read More

    [Granulomatous slack skin associated with metastatic testicular seminoma].
    Ann Dermatol Venereol 2017 Apr 7. Epub 2017 Apr 7.
    Service de dermatologie, hôpital Saint-Louis, AP-HP, 1, avenue Claude-Vellefaux, 75010 Paris, France. Electronic address:
    Background: Granulomatous slack skin (GSS) is an extremely rare subtype of T-cell lymphoma, a variant of mycosis fungoides (MF). Herein, we describe the first reported case of GSS associated with metastatic testicular seminoma.

    Patients And Methods: A 28-year-old male patient presented with circumscribed erythematous loose skin masses, especially in the body folds and which had been relapsing for 4years. Read More

    Hematopoietic stem cell transplantation in advanced cutaneous T-cell lymphoma.
    J Dermatol 2017 Apr 9. Epub 2017 Apr 9.
    Department of Dermatology, Kurume University School of Medicine, Kurume, Japan.
    We retrospectively reviewed data pertaining to five patients with cutaneous T-cell lymphoma (CTCL) who had received hematopoietic stem cell transplantation (HSCT) between 2004 and 2015 at Kurume University Hospital, along with their clinical data until March 2016. For patients with advanced CTCL eligible for HSCT, autologous HSCT was performed when they responded well to chemotherapy, and allogeneic HSCT was selected for patients with advanced mycosis fungoides (MF)/Sézary syndrome (SS) and CTCL other than MF/SS with poor chemosensitivity. Two patients (primary cutaneous anaplastic large cell lymphoma and primary cutaneous CD8(+) aggressive epidermotropic cytotoxic T-cell lymphoma) who responded well to chemotherapy received autologous HSCT: one patient was alive in partial remission and the other died due to therapy-related acute myeloid leukemia without disease relapse. Read More

    Primary Cutaneous Follicular Helper T-Cell Lymphoma: A Case Series and Review of the Literature.
    Am J Dermatopathol 2017 May;39(5):374-383
    *Department of Pathology and Laboratory Medicine, Weill Cornell Medicine, New York, NY; †Department of Dermatology, University of Colorado Anschutz Medical College, Aurora, CO; and ‡Division of Hematology and Oncology, Weill Cornell Medicine, New York, NY.
    Primary cutaneous follicular helper T-cell (Tfh) lymphoma is a recently described variant of peripheral T-cell lymphoma-not otherwise specified. This particular variant, usually presenting as a sudden onset of multiple plaques and nodules, is characterized by tumoral atypical T cells that express an array of Tfh markers, such as inducible T-cell costimulator, Bcl-6, CXCL13, PD-1, and CD10. The authors now present 3 patients whose known clinical skin findings are consistent with PTCL of Tfh origin (PTCL-Tfh). Read More

    European Organisation for Research and Treatment of Cancer consensus recommendations for the treatment of mycosis fungoides/Sézary syndrome - Update 2017.
    Eur J Cancer 2017 May 31;77:57-74. Epub 2017 Mar 31.
    Department of Dermatology, Medical University of Vienna, Vienna, Austria.
    In order to provide a common standard for the treatment of mycosis fungoides (MF) and Sézary syndrome (SS), the European Organisation for Research and Treatment of Cancer-Cutaneous Lymphoma Task Force (EORTC-CLTF) published in 2006 its consensus recommendations for the stage-adapted selection of management options for these neoplasms. Since then, the understanding of the pathophysiology and epidemiology of MF/SS has advanced, the staging system has been revised, new outcome data have been published and novel treatment options have been introduced. The purpose of the present document is to update the original recommendations bearing in mind that there are still only a limited number of controlled studies to support treatment decisions for MF/SS and that often treatment is determined by institutional experience and availability. Read More

    IL-32 induces indoleamine 2,3-dioxygenase(+)CD1c(+) dendritic cells and indoleamine 2,3-dioxygenase(+)CD163(+) macrophages: Relevance to mycosis fungoides progression.
    Oncoimmunology 2017 5;6(2):e1181237. Epub 2016 May 5.
    Laboratory for Investigative Dermatology, The Rockefeller University , New York, NY, USA.
    Mycosis fungoides (MF) progresses from patch to tumor stage by expansion of malignant T-cells that fail to be controlled by protective immune mechanisms. In this study, we focused on IL-32, a cytokine, highly expressed in MF lesions. Depending on the other cytokines (IL-4, GM-CSF) present during in vitro culture of healthy volunteers' monocytes, IL-32 increased the maturation of CD11c(+) myeloid dendritic cells (mDC) and/or CD163(+) macrophages, but IL-32 alone showed a clear ability to promote dendritic cell (DC) differentiation from monocytes. Read More

    Surgical Excision of Mycosis Fungoides Using Thumb-Sparing Reconstruction.
    Hand (N Y) 2017 Mar 23;12(2):NP22-NP26. Epub 2016 Sep 23.
    University of Toronto, Ontario, Canada; Sunnybrook Health Sciences Centre, Toronto, Ontario, Canada.
    Background: The differential for soft tissue tumors of the hand and upper limb is broad. Hematologic malignancy remains quite low on the differential for soft tissue tumors involving the hand, and there is little in the literature describing surgical management of such cutaneous manifestations. When the tumor is large or involves the thumb, careful consideration of reconstructive options is required. Read More

    Eosinophilic Dermatosis of Hematologic Malignancy.
    Actas Dermosifiliogr 2017 Mar 22. Epub 2017 Mar 22.
    Servicio de Dermatología, Hospital Arnau de Vilanova, Valencia, España.
    Dermatosis characterized by tissue eosinophilia arising in the context of hematologic disease is known as eosinophilic dermatosis of hematologic malignancy. The most commonly associated malignancy is chronic lymphocytic leukemia. Eosinophilic dermatosis of hematologic malignancy is a rare condition with a wide variety of clinical presentations, ranging from papules, erythematous nodules, or blisters that simulate arthropod bites, to the formation of true plaques of differing sizes. Read More

    Primary cutaneous anaplastic large cell lymphoma.
    J Cutan Pathol 2017 Jun 25;44(6):570-577. Epub 2017 Apr 25.
    Department of Pathology, Stanford University School of Medicine, Stanford, California.
    Primary cutaneous anaplastic large cell lymphoma (PC-ALCL) is a CD30+ lymphoproliferative disorder (LPD) of the skin with a relatively good prognosis in the absence of high-stage disease. CD30+ LPDs comprise approximately 25%-30% of primary cutaneous lymphomas and as a group represent the second most common clonal T-cell neoplasm of the skin behind mycosis fungoides. Diagnosis of PC-ALCL relies strongly on clinicopathologic correlation given the potential morphologic, clinical and molecular overlap with the other cutaneous CD30+ LPD, lymphomatoid papulosis, and more aggressive hematolymphoid neoplasms. Read More

    Mycosis Fungoides and Sezary Syndrome.
    Hematol Oncol Clin North Am 2017 Apr;31(2):297-315
    Department of Dermatology, Yale University School of Medicine, New Haven, CT 06510, USA.
    Mycosis fungoides and the Sezary syndrome (SS) are rare lymphomas of CD4(+) helper T cells. There is stagewise progression from patch/plaques to thicker tumor lesions/diffuse erythroderma. Blood involvement is a characteristic of SS. Read More

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