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JAAD Case Rep 2019 Apr 5;5(4):348-351. Epub 2019 Apr 5.

Department of Radiation Oncology, Wake Forest Baptist Medical Center, Winston-Salem, North Carolina.

Photodermatol Photoimmunol Photomed 2019 Apr 21. Epub 2019 Apr 21.

First Dermatology Department, Aristotle University of Thessaloniki, Greece.

Pagetoid reticulosis (PR), also known as Woringer-Kolopp disease, is a rare variant of mycosis fungoides with distinctive clinicopathologic features. It clinically manifests as a solitary, erythematous, gradually enlarging, scaly or verrucous plaque on the lower extremities, and due to its indolent course and non-specific clinical features, may remain undiagnosed for years. In the current we describe the clinical and dermoscopic characteristics of a rare case of PR disease, and correlate them with the corresponding histopathologic findings. Read More

Br J Dermatol 2019 Apr 20. Epub 2019 Apr 20.

Department of Dermatology, University Hospital Zurich, University of Zurich, Zurich, Switzerland.

Ingenol mebutate is a macrocyclic diterpene ester, naturally found in the sap of the Australian plant Euphorbia peplus, which proved efficacious for actinic keratosis. In clinical routine, we observed local improvement of MF upon application of ingenol mebutate in MF patients treated for coincidental actinic keratosis within direct proximity of/overlapping with MF skin lesions. Hence, the objective of this study was to assess the effect of topical ingenol mebutate on MF skin lesions. Read More

Am J Clin Dermatol 2019 Apr 16. Epub 2019 Apr 16.

Department of Dermatology and Cutaneous Biology, Sidney Kimmel College at Jefferson University Hospital, Thomas Jefferson University, 833 Chestnut Street, Suite 740, Philadelphia, PA, 19107, USA.

Mycosis fungoides is the most common form of cutaneous T cell lymphoma. Although normally presenting to physicians at an early stage and with an indolent course, mycosis fungoides can have a varied presentation. The National Comprehensive Cancer Network (NCCN) has created guidelines for the treatment and staging of mycosis fungoides. Read More

J Cutan Pathol 2019 Apr 15. Epub 2019 Apr 15.

Department of Dermatology, Mayo Clinic Rochester, Minnesota.

Background: Mycosis fungoides (MF) is characterized by epidermotropic atypical lymphocytes in the absence of spongiosis. However , we describe a unique presentation of MF with spongiosis, mimicking benign inflammatory dermatoses and highlight the importance of pathologic interpretation for diagnostic confirmation.

Methods: A cross-sectional study of consecutive patients diagnosed with MF with spongiosis was conducted. Read More

J Pediatr Hematol Oncol 2019 Apr 8. Epub 2019 Apr 8.

Children's National Medical Center, Washington, DC.

Cutaneous T-cell lymphomas are very rare in children. Although mycosis fungoides is the most common of these rare cutaneous T-cell lymphomas in children, transformation to an aggressive malignancy remains extremely uncommon, and there are no clear guidelines for clinical management in the pediatric population. In addition, the increased usage of next-generation sequencing for pediatric patients with unusual malignancies may result in the discovery of pathogenic germline mutations, though the association between these mutations and the patient's cancer is not always clear. Read More

Am J Surg Pathol 2019 Apr 8. Epub 2019 Apr 8.

Department of Dermatology, Research Unit Dermatopathology, Medical University of Graz, Graz, Austria.

Papular mycosis fungoides (PMF) is a rare variant of mycosis fungoides (MF). The exact nosology and prognosis of PMF are still unclear. We retrospectively identified cases of PMF from the files of the Department of Dermatology of the Medical University of Graz, Austria, and checked the follow-up data. Read More

Blood Adv 2019 Apr;3(7):1175-1184

Division of Dermatology, Department of Medicine, and.

Mycosis fungoides (MF), the most common type of cutaneous T-cell lymphoma, is believed to represent a clonal expansion of a transformed skin-resident memory T cell. T-cell receptor (TCR) clonality (ie, identical sequences of rearranged TCRα, TCRβ, and TCRγ), the key premise of this hypothesis, has been difficult to document conclusively because malignant cells are not readily distinguishable from the tumor-infiltrating reactive lymphocytes that contribute to the TCR clonotypic repertoire of MF. Here, we have successfully adopted targeted whole-exome sequencing (WES) to identify the repertoire of rearranged TCR genes in tumor-enriched samples from patients with MF. Read More

Yonago Acta Med 2019 Mar 28;62(1):153-158. Epub 2019 Mar 28.

Division of Dermatology, Department of Medicine of Sensory and Motor Organs, School of Medicine, Tottori University Faculty of Medicine, Yonago 683-8503, Japan.

Mycosis fungoides, the most common subtype of cutaneous T-cell lymphoma, displays a broad spectrum of clinical, histological and phenotypic variants with different prognostic impacts. The classic immunophenotype is CD3+/CD4+/CD45RO+memory T cells. CD4/CD8 double-negative mycosis fungoides is rare. Read More

Cancer Manag Res 2019 20;11:2241-2251. Epub 2019 Mar 20.

Dermatology Department, Centre Hospitalier Le Mans, Le Mans, France,

Mycosis fungoides (MF) is a low-grade cutaneous lymphoma accounting for more than half of primary cutaneous T-cell lymphomas (CTCLs). Due to the rarity of CTCL, randomized studies are lacking, and treatment is based mainly on the recent published European Organisation for Research and Treatment of Cancer guidelines. Basically, early-stage MF is treated with skin-directed treatments, whereas advanced-stage MF requires more aggressive therapies. Read More

Am J Dermatopathol 2019 Mar 29. Epub 2019 Mar 29.

Departments of Dermatology.

Mycosis fungoides (MF) is the most common type of cutaneous T-cell lymphoma, primary cutaneous CD30 lymphoproliferative disorders (pc CD30 LPD) being the second most prevalent. There is evidence that MF and pc CD30 LPD may coexist and share T-cell clonality, suggesting a common origin. These findings were supported by a T-cell receptor clonality assessment by the polymerase chain reaction coupled with capillary electrophoresis, although results produced by this method may be ambiguous. Read More

Am J Dermatopathol 2019 Mar 20. Epub 2019 Mar 20.

Medical University of South Carolina, Charleston, SC.

Syringotropic mycosis fungoides (MF) is classified under folliculotropic MF. Although there is significant overlap between the 2, this study demonstrates that folliculotropism is frequently present in syringotropic MF, and when not present, the specimen did not include a follicle to examine. In addition, few of the pathology reports mentioned folliculotropism or syringotropism, although this is an important prognostic feature. Read More

Oncol Lett 2019 May 1;17(5):4055-4059. Epub 2019 Mar 1.

Department of Pathology, Colentina University Hospital, 020125 Bucharest, Romania.

Dendritic cells (DCs) are antigen-presenting cells with an important role in the innate and adaptive immune system. In skin lesions, cutaneous DCs (Langerhans cells, dermal DCs and plasmacytoid DCs) are involved in immune activation in inflammatory benign lesions, as well as in malignant lymphoid proliferations. Density and distribution of DCs in the dermal infiltrate can be helpful to differentiate benign, reactive infiltrate from malignant nature of the lymphoid population. Read More

J Cutan Med Surg 2019 Apr 3:1203475419840629. Epub 2019 Apr 3.

1 Department of Dermatology and Skin Science, University of British Columbia, Vancouver, Canada.

Cutaneous T-cell lymphomas (CTCL) are a heterogeneous group of non-Hodgkin lymphomas characterized by an infiltration of malignant monoclonal T lymphocytes into the skin. Mycosis fungoides (MF), the most common subtype, and the rarer Sézary syndrome (SS), are considered the classical forms of CTCL, which, because of a varying presentation and lack of genetic and immunophenotypical markers, can often have a delayed diagnosis. With skin-directed topical treatment being the mainstay of therapy in the early stages, there is an absence of long-term curative therapies for advanced disease. Read More

Br J Haematol 2019 Apr 1. Epub 2019 Apr 1.

Department of Surgery, City of Hope National Medical Center, Duarte, CA, USA.

J Am Acad Dermatol 2019 Mar 28. Epub 2019 Mar 28.

Department of Dermatopathology, St. John's Institute of Dermatology, Guys and St Thomas' Foundation Trust, London, UK.

Background: We present a distinctive type of acquired vascular proliferation, for which we propose the name of poikilodermatous plaque-like hemangioma (PPH).

Objective: The aim of the study is to summarise the clinical and histopathological features in a case series of PPH.

Methods: Sixteen cases were identified from the routine clinical and referral practice of the authors. Read More

Eur J Intern Med 2019 Mar 19. Epub 2019 Mar 19.

Department of Internal medicine and Infectious diseases, Cliniques universitaires Saint-Luc, Université Catholique de Louvain, 10 av Hippocrate, 1200 Brussels, Belgium.

J Dermatolog Treat 2019 Mar 20:1-8. Epub 2019 Mar 20.

a Pharmerit International LP , Bethesda , MA , USA.

Introduction: The National Comprehensive Cancer Network and the European Organization for Research and Treatment of Cancer recommend extracorporeal photopheresis (ECP) as systemic therapy for cutaneous T-cell lymphoma (CTCL).

Objective: To investigate real-world use of ECP in CTCL patients in the US.

Methods: Data from the Truven MarketScan database (2010-2015) were used to create a cohort of CTCL patients receiving systemic treatment. Read More

JAMA Dermatol 2019 Mar 20. Epub 2019 Mar 20.

Research Unit for Photodermatology, Department of Dermatology and Venereology, Medical University of Graz, Graz, Austria.

Importance: Psoralen-UV-A (PUVA) photochemotherapy is standard first-line treatment for skin-limited, early-stage mycosis fungoides capable of producing high initial complete response (CR) rates. However, much remains unknown about PUVA's therapeutic mechanisms, optimal duration and frequency of treatment, dose escalation, or use as maintenance therapy.

Objectives: To evaluate low-dose, low-frequency PUVA, and whether maintenance treatment extends disease-free remission in patients with mycosis fungoides. Read More

J Cutan Pathol 2019 Mar 18. Epub 2019 Mar 18.

Department of Dermatology, The University of Texas MD Anderson Cancer Center, Houston, Texas.

Oncotarget 2019 Feb 12;10(13):1267-1268. Epub 2019 Feb 12.

Henry K. Wong: Department of Dermatology, University of Arkansas for Medical Sciences, Little Rock, AR, USA.

JAAD Case Rep 2019 Mar 22;5(3):240-241. Epub 2019 Feb 22.

Department of Dermatology, University of Minnesota, Minneapolis, MN.

Am J Dermatopathol 2019 Feb 28. Epub 2019 Feb 28.

Departments of Pathology, and.

Background: Cell adhesion molecules are essential to lymphocyte migration in neoplastic and inflammatory skin diseases. Our aim was to investigate possible differences in cell adhesion molecule expression between mycosis fungoides (MF) and inflammatory skin diseases (drug reactions and allergic contact dermatitis).

Methods: We selected 33 biopsies from patients with MF and 10 biopsies of patients with inflammatory skin diseases from Department of Pathology-Universidade Federal de São Paulo (UNIFESP) from January 1997 to December 2013. Read More

Dermatol Ther 2019 Mar 6:e12870. Epub 2019 Mar 6.

Chair of Dermatology, University of Rome "G.Marconi", Rome, Italy.

Br J Dermatol 2019 Mar 5. Epub 2019 Mar 5.

Dermatology Department, University Hospital, Bordeaux, and INSERM U1053 Bordeaux Research in translational oncology, Team 3 Oncogenesis of cutaneous lymphomas, University of Bordeaux, France.

Controversy exists regarding the risk and prognosis of lymphomas under biologics . Risk evaluation must consider the underlying medical condition -as chronic inflammatory diseases are associated with an excess risk of lymphoma -and ongoing treatments (azathioprine, cyclosporine) . To date, a few isolated cases and two small series of primary cutaneous lymphomas (PCL) under biologics- mostly mycosis fungoides (MF) - have been reported . Read More

JAAD Case Rep 2019 Mar 21;5(3):231-233. Epub 2019 Feb 21.

Department of Dermatology, Mayo Clinic, Scottsdale, Arizona.

Ann Dermatol Venereol 2019 Mar 1. Epub 2019 Mar 1.

Service dermatologie, CHU Fattouma Bourguiba de Monastir, université de Monastir, Tunisie.

Arkh Patol 2019;81(1):9-17

Saint Petersburg State Pediatric Medical University, Ministry of Health of Russia, Saint Petersburg, Russia.

Mycosis fungoides (MF) is the most common primary cutaneous epidermotropic T-cell lymphoma (80%). The accurate diagnosis of MF confirmed only by clinical, histological and immunohistochemical signs amounts to 50-75%.

Objective: To investigate genetic markers (FOXP3, STAT4, IL-12B) for the early diagnosis of MF, to estimate the informative value of used diagnostic techniques (histology, immunophenotyping), and to determine clonality by the T-cell receptor γ-chain genes. Read More

Clin Exp Dermatol 2019 Mar 1. Epub 2019 Mar 1.

Department of Dermatology, Amiens University Hospital, Amiens, France.

Chin Clin Oncol 2019 Feb;8(1):10

Division of Hematologic Malignancies and Hematopoietic Stem Cell Transplantation, Department of Medical Oncology, Sidney Kimmel Medical College, Thomas Jefferson University, Philadelphia, PA, USA.

Cutaneous T-cell lymphomas (CTCLs) are a heterogeneous and relatively rare family of extranodal non-Hodgkin's lymphomas (NHL) that are primarily localized to the skin. Most patients present with cutaneous patches, plaques, tumors, more rarely with erythroderma. The type of skin lesions and the surface extent of skin involvement, as well as the presence of extracutaneous disease, are the most important prognostic factors in patients with CTCL. Read More

Chin Clin Oncol 2019 Feb;8(1)

Department of Dermatology and Cutaneous Biology, Jefferson University Hospital, Philadelphia, PA, USA.

Background: Mycosis fungoides (MF), the most common form of cutaneous T-cell lymphoma, remains a challenge for clinicians to stage and manage. Classically, MF is determined through histopathologic evidence of a neoplastic infiltrate within the epidermis. In certain patients, however, the infiltrate extends into the hair follicles and sweat glands. Read More

Australas J Dermatol 2019 Feb 26. Epub 2019 Feb 26.

Department of Dermatology, Westmead Hospital, Sydney, New South Wales, Australia.

Cutaneous T-cell lymphoma is an uncommon group of non-Hodgkin's lymphoma primarily affecting the skin. It is comprised of a variety of entities with different clinical behaviours and prognosis. Mycosis fungoides is the commonest subtype, and Sézary syndrome is a much rarer form of cutaneous T-cell lymphoma. Read More

Clin Cancer Res 2019 Feb 26. Epub 2019 Feb 26.

department of Dermatology, Bispebjerg Hospital.

Purpose: Mycosis fungoides (MF) is one of the most common types of extranodal T-cell lymphomas, considered to be caused by malignant transformation of the mature T-cell residing in the skin. However, some clinical observations such as the multifocal distribution of MF lesions or patterns of relapse after radiotherapy are not readily explainable by the mature T-cell origin theory.

Experimental Design: We have performed a detailed analysis of T-cell receptor (TCR) rearrangements in single malignant cells and in biopsies from MF tumors composed of >80% of malignant cells using next-generation sequencing (NGS) to pinpoint the relationship between neoplastic cells in MF. Read More

Case Rep Dermatol Med 2019 20;2019:2380598. Epub 2019 Jan 20.

Institute of Cardiology/University Cardiology Foundation and Post-Graduation Program, Ivo Corrêa-Meyer Institute of Ophthalmology, Porto Alegre-RS, Brazil.

Background: Ophthalmic findings in mycosis fungoides (MF) can be highly variable. It seems that the prevalence of ophthalmic findings could be much more common than previously assumed.

Objective: To present case series examined in the last 12 months, together with a literature review. Read More

J Eur Acad Dermatol Venereol 2019 Feb 23. Epub 2019 Feb 23.

National Skin Centre, Singapore, Singapore.

Background: Limited information exists regarding survival of Asian patients with mycosis fungoides (MF) and Sézary syndrome (SS).

Objective: To evaluate the epidemiology, outcome and prognostic factors of these patients.

Methods: A retrospective review of MF/SS cases diagnosed from 2000 to 2011 at a tertiary referral dermatology centre in Singapore was performed. Read More

Onco Targets Ther 2019 7;12:1085-1094. Epub 2019 Feb 7.

Department of Medicine, Alpert Medical School of Brown University, Providence, RI, USA,

Cutaneous T-cell lymphoma (CTCL) poses unique treatment challenges, given its range of presentations and numerous systemic therapy options. These options often lack comparative evidence or are characterized by low response rates and short remission duration in relapsed/refractory disease. The approval of mogamulizumab, a humanized, glycoengineered IgG1κ monoclonal antibody targeting the chemokine receptor type 4 (CCR4) chemokine receptor, brings a novel tool into the spectrum of treatment options for advanced CTCL and adult T-cell leukemia/lymphoma (ATLL). Read More

Pediatr Dermatol 2019 Feb 21. Epub 2019 Feb 21.

Section of Pediatric Dermatology, Departments of Dermatology and Pediatrics, Medical College of Wisconsin, Milwaukee, Wisconsin.

Immunosuppression following organ transplantation is a known risk factor for the development of lymphoproliferative disorders. Mycosis fungoides, a rare entity in pediatric patients, has seldom been reported as a post-transplant lymphoproliferative disorder. We report a case of folliculotropic mycosis fungoides in a pediatric patient following liver transplantation that was initially diagnosed as tinea capitis. Read More

Radiother Oncol 2019 Feb 31;131:88-92. Epub 2018 Dec 31.

Department of Radiation Oncology, The University of Texas MD Anderson Cancer Center, United States. Electronic address:

Background And Purpose: A lower proportion of CD8+ tumor infiltrating lymphocytes in mycosis fungoides (MF) patients is associated with worse survival. However, it is not known whether circulating CD4:CD8 ratio is a prognosticator of response to total skin electron beam therapy (TSEBT).

Methods And Materials: We identified 126 MF patients treated with TSEBT from 2001 to 20014 at two high-volume academic centers. Read More

Blood Adv 2019 Feb;3(4):519-530

Instititute of Immunology and Immunotherapy, University of Birmingham, Birmingham, United Kingdom; and.

Immunotherapy is a valuable treatment for many cancer patients, and there is considerable interest in understanding the mechanisms of immune evasion to guide appropriate management. Mycosis fungoides (MF) is a malignant disorder of skin-homing CD4 T cells, and it exhibits a highly variable clinical course during which the tumor-specific immune response may be an important determinant. An unusual feature of MF is that tumor-infiltrating lymphocytes (TILs) must attempt to control a malignant cell from within their own lineage. Read More

J Am Acad Dermatol 2019 Feb 11. Epub 2019 Feb 11.

Department of Hematology, MedStar Washington Hospital Center, 110 Irving St, Washington DC, 20010.

J Dtsch Dermatol Ges 2019 02;17(2):186-188

Dermatology Service, Department of Medicine, Memorial Sloan Kettering Cancer Center, and Weill Cornell Medicine, New York, NY, USA.

Int J Dermatol 2019 Feb 14. Epub 2019 Feb 14.

Division of Dermatology, Department of Medicine, Sunnybrook Health Sciences Centre, Toronto, Canada.

Background: Mycosis fungoides (MF) typically has a CD4 CD8 T-cell phenotype. Rare cases of CD4 CD8 , CD4 CD8 , or CD4 CD8 immunophenotypes have been described. Little is known about the impact of MF immunophenotypes on disease behavior. Read More

Leuk Lymphoma 2019 Feb 14:1-3. Epub 2019 Feb 14.

a Department of Radiation Oncology , Virginia, Commonwealth University Health System, Massey Cancer Center.

Clin Lymphoma Myeloma Leuk 2019 Jan 2. Epub 2019 Jan 2.

University of Arizona, Tucson, AZ.

Background: Serum copper has been reported to be increased in various cancers, including lymphoma. The purpose of the present study was to investigate the clinical and prognostic importance of serum copper levels in patients with cutaneous T-cell lymphoma (CTCL).

Patients And Methods: Serum copper was measured in 60 men and 38 women with mycosis fungoides (MF) and 14 men and 3 women with erythrodermic CTCL (6 with Sézary syndrome) consecutively evaluated from July 1980 to June 1985. Read More

JAAD Case Rep 2019 Feb 31;5(2):201-204. Epub 2019 Jan 31.

Columbia University Medical Center, Department of Dermatology, New York, New York.

J Cutan Pathol 2019 May 29;46(5):335-342. Epub 2019 Mar 29.

Department of Dermatology, Los Angeles Medical Center (LAMC), Southern California Kaiser Permanente, Los Angeles, California.

Introduction: Granulomatous mycosis fungoides (MF) is a rare variant in which granulomas are associated with other typical signs of MF. Its prognosis is worse than that of classical MF. Plasmacytoid dendritic cells (PDCs) are a subset of interferon-producing dendritic cells that link the innate and the adaptative immune responses. Read More

JAAD Case Rep 2019 Feb 30;5(2):180-183. Epub 2019 Jan 30.

Georgetown University School of Medicine, Department of Dermatology, Washington, DC.

J Dermatolog Treat 2019 Feb 27:1-4. Epub 2019 Feb 27.

a 1st Department of Dermatology "Andreas Syggros" Hospital , Medical School, National and Kapodistrian University of Athens , Athens , Greece.

Although anti-TNFα agents have revolutionized the treatment of many inflammatory diseases, various concerns have been reported regarding the risks of cancer development, as well as acceleration of the progression of subclinical, preexisting malignancies. In this case series, we investigated the provocative effect of anti-TNFα drugs in the development of cutaneous mycosis fungoides (MF)-like lymphoproliferative reactions. We describe five patients aged between 25-63 diagnosed with autoimmune disorders (psoriatic arthritis - one patient, Crohn's disease - one patient and ankylosing spondylitis - three patients) who received anti-TNFα agents before the development of a cutaneous lymphoproliferative reaction. Read More

J Am Acad Dermatol 2019 Feb 1. Epub 2019 Feb 1.

Department of Pathology, Memorial Sloan Kettering Cancer Center and Weill Cornell Medical College, New York, New York.

Background: Follicular mucinosis (FM), which is defined by mucin accumulation within follicular epithelium, may occur in mycosis fungoides (MF). FM without MF is occasionally reported in systemic hematologic malignancies and may be diagnostically challenging.

Objective: To describe clinicopathologic characteristics of FM in patients with hematologic malignancies other than MF. Read More