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    Bath Psoralen-ultraviolet A and Narrowband Ultraviolet B Phototherapy as Initial Therapy for Early-stage Mycosis Fungoides: A Retrospective Cohort of 267 Cases at the University of Toronto.
    Clin Lymphoma Myeloma Leuk 2017 Jun 19. Epub 2017 Jun 19.
    Division of Dermatology, Department of Medicine, University of Toronto, Toronto, ON, Canada.
    Background: Phototherapy is used frequently to treat early-stage mycosis fungoides (MF). The effectiveness of bath psoralen-ultraviolet A (bath PUVA) and narrowband ultraviolet B (nbUVB) in MF is well established. However, evidence is limited comparing the effectiveness of the 2 modalities for early-stage MF. Read More

    Early clinical manifestations of Sézary syndrome: A multicenter retrospective cohort study.
    J Am Acad Dermatol 2017 Jul 11. Epub 2017 Jul 11.
    University of Alberta, Edmonton, Canada; Department of Dermatology, University of Copenhagen, Copenhagen, Denmark.
    Background: Classic Sézary syndrome (SS) is defined by erythroderma, generalized lymphadenopathy, and leukemic blood involvement. Clinical observations suggest that SS begins as a nonerythrodermic disease.

    Objective: To describe the early clinical characteristics of patients with SS. Read More

    Syringotropic Mycosis Fungoides: A Rare Form of Cutaneous T-cell Lymphoma Enabling a Histopathologic "Sigh of Relief."
    Am J Dermatopathol 2017 May 18. Epub 2017 May 18.
    Departments of *Internal Medicine, and †Dermatology, UC Irvine Health, Irvine, CA.
    Syringotropic mycosis fungoides (STMF) is a very rare variant of cutaneous T-cell lymphoma. It follows a much milder disease course than its clinically indistinguishable adnexal counterpart, folliculotropic mycosis fungoides (FMF). We report a case of a 36-year-old man who presented with erythematous, studded papules and plaques on the left upper extremity and right anterior thigh diagnosed as mycosis fungoides (MF) Stage 1A on initial superficial shave biopsy. Read More

    Eruptive Seborrheic Keratoses Restricted to Plaque/Patch-Stage Mycosis Fungoides.
    Case Rep Dermatol 2017 May-Aug;9(2):35-39. Epub 2017 Jun 8.
    Department of Dermatology, CHU Sart Tilman, University of Liège, Liège, Belgium.
    Eruptive seborrheic keratoses (ESK) are rare in dermatology. They are usually inflammatory in nature and may be encountered as Leser-Trélat sign. ESK may also be simultaneously observed with hepatic angiomas, chemotherapy, segmental neurofibromatosis, HIV or erythrodermic pityriasis rubra pilaris, psoriasis, and drug eruption. Read More

    CD8(+) mycosis fungoides: A low-grade lymphoproliferative disorder.
    J Am Acad Dermatol 2017 Jul 1. Epub 2017 Jul 1.
    Department of Dermatology, Northwestern University, Feinberg School of Medicine, Chicago, Illinois. Electronic address:
    Background: The prognosis of the CD8(+) subtype of mycosis fungoides (MF) is controversial. Although most authors believe that determining the presence of this cell surface antigen has no prognostic value, others have observed a more indolent course for CD8(+) MF compared with CD4(+) MF.

    Objectives: To review the cases of CD8(+) MF in the pediatric and adult populations seen at our institution. Read More

    Annual Facility Treatment Volume and Patient Survival for Mycosis Fungoides and Sézary Syndrome.
    Clin Lymphoma Myeloma Leuk 2017 Jun 24. Epub 2017 Jun 24.
    Department of Therapeutic Radiology, Yale School of Medicine, New Haven, CT.
    Background: Management of mycosis fungoides and Sézary syndrome (MF/SS) is complex, and randomized evidence to guide treatment is lacking. The institutional treatment volumes for MF/SS might vary widely nationally and influence patient survival.

    Patients And Methods: Using the National Cancer Database, we identified patients with a diagnosis of MF/SS from 2004 to 2011 in the United States who had received treatment at a reporting facility. Read More

    The Histopathological Spectrum of Pseudolymphomatous Infiltrates in Cutaneous Lupus Erythematosus.
    Am J Dermatopathol 2017 Jun 20. Epub 2017 Jun 20.
    *Research Unit Dermatopathology, Department of Dermatology, Medical University of Graz, Graz, Austria; †Anatomic Pathology Unit, Hospital Universitário Polydoro Ernani de São Thiago, Universidade Federal de Santa Catarina, Florianópolis, Brazil; ‡Anatomic Pathology Unit, Macerata General Hospital, Macerata, Italy; §Anatomic Pathology Unit, Department of Surgical Science and Integrated Diagnostics, University of Genoa, IRCCS AOU San Martino IST, Genoa, Italy; ¶Dermatopathology Unit, San Gallicano Dermatology Institute, Rome, Italy; ‖Department of Dermatology, Galliera Hospital, Genoa, Italy; **School of Pathology, University of Milan, Fondazione IRCCS Ca' Granda-Ospedale Maggiore Policlinico, Milan, Italy; and ††Department of Dermatology, Hospital Clínico Universitario Lozano Blesa, Zaragoza, Spain.
    The occurrence of pseudolymphomatous infiltrates in cutaneous lupus erythematosus (cLE) is described mainly in lupus panniculitis and lupus tumidus/lymphocytic infiltration of the skin (Jessner-Kanof). We collected 15 cases of pseudolymphomatous cLE other than lupus panniculitis and lupus tumidus (M:F = 4:11; age range: 23-79 years; mean age: 50.9 years; median age: 57 years). Read More

    Lichenoid Granulomatous Mycosis Fungoides.
    Am J Dermatopathol 2017 Aug;39(8):614-617
    *Department of Pathology, Hospital Universitario 12 de Octubre, Facultad de Medicina, Universidad Complutense, Instituto de Investigación I+12, Madrid, Spain; and †Department of Dermatology, Hospital Universitario 12 de Octubre, Facultad de Medicina de la Universidad Complutense, Instituto de Investigación I+12, Madrid, Spain.
    The presence of a granulomatous reaction in cutaneous lymphomas has been described in the past, especially in mycosis fungoides (MF), where a "granulomatous" variant of the disease is well known. We describe a patient with granulomatous MF (GMF) who has been followed for 13 years presenting with erythematosquamous plaques on his fingers and toes, ankles, heels, and abdomen, which on microscopic examination showed a lichenoid granulomatous reaction admixed with a neoplastic proliferation of small-sized, atypical CD4 lymphocytes. GMF is characterized by a granulomatous reaction intermingled with the dermal infiltrate of MF which may even reach the subcutaneous tissue. Read More

    Upregulation of inhibitory signaling receptor programmed death marker-1 (PD-1) in disease evolution from cutaneous lymphoid dyscrasias to mycosis fungoides and Sezary's syndrome.
    Ann Diagn Pathol 2017 Jun 10;28:54-59. Epub 2017 Feb 10.
    Department of Pathology and Laboratory Medicine, New York Presbyterian Hospital-Weill Cornell Medical Center, New York, NY 10065, USA. Electronic address:
    Background: Negative immunoregulatory checkpoints impede effective immune responses to tumor and reduce the action of anticancer agents. One such example is programmed death marker-1 (PD-1), an inhibitory signaling receptor expressed on activated and regulatory T-cells. PD-1 expression was reported in a few reports, but the expression profile of PD-1 and mycosis fungoides (MF) remains largely to be characterized. Read More

    [Mycosis fungoides in a heart transplant recipient].
    Ann Dermatol Venereol 2017 Jun 22. Epub 2017 Jun 22.
    Service de dermatologie, groupe hospitalier du Havre, hôpital J.-Monod, BP 24, 76083 Le Havre, France.
    Background: Skin cancer occurs frequently in organ transplant patients as a result of induced immunosuppression. Most cases involve carcinomas or B-cell lymphomas induced by the Epstein Barr virus (EBV). Cutaneous T-cell lymphomas remain rare. Read More

    Racial disparity in mycosis fungoides: An analysis of 4495 cases from the US National Cancer Database.
    J Am Acad Dermatol 2017 Jun 20. Epub 2017 Jun 20.
    Department of Dermatology, The Second Xiangya Hospital, Central South University, Changsha, Hunan, People's Republic of China. Electronic address:
    Background: Studies have shown contradictory results regarding the survival outcomes among white, African American, and Asian patients with mycosis fungoides (MF).

    Objective: To evaluate the survival outcomes among white, African American, and Asian patients with MF and to determine other prognostic factors of the disease.

    Methods: The US National Cancer Database was used to identify patients with histologically confirmed MF from 2004 to 2014. Read More

    Gene expression analysis in Cutaneous T-Cell Lymphomas (CTCL) highlights disease heterogeneity and potential diagnostic and prognostic indicators.
    Oncoimmunology 2017 17;6(5):e1306618. Epub 2017 Mar 17.
    Department of Dermatology, The University of Texas MD Anderson Cancer Center, Houston, TX, USA.
    Cutaneous T-Cell Lymphomas (CTCL) are rare, but potentially devastating malignancies, whose pathogenesis remains poorly elucidated. Unfortunately, currently it is not possible to predict based on the available criteria in which patients the cancer will progress and which patients will experience an indolent disease course. Furthermore, at early stages this malignancy often masquerades as psoriasis, chronic eczema or other benign inflammatory dermatoses. Read More

    Complete resolution of mycosis fungoides tumors with imiquimod 5% cream: a case series.
    J Dermatolog Treat 2017 Mar 2:1-3. Epub 2017 Mar 2.
    b Department of Dermatology , The University of Texas MD Anderson Cancer Center , Houston , TX , USA.
    Objective: To demonstrate the clinical efficacy of topical 5% imiquimod for mycosis fungoides (MF) tumors.

    Background: Treatment of tumor-stage MF represents a therapeutic challenge because of a limited number of effective topical therapies. Single tumors can be treated with localized radiation but may recur. Read More

    Profiling of peripheral T-cell lymphomas in Kerala, South India: A 5-year study.
    Indian J Pathol Microbiol 2017 Apr-Jun;60(2):206-208
    Division of Pathology, Regional Cancer Centre, Thiruvananthapuram, Kerala, India.
    Background: Peripheral T-cell lymphomas (PTCLs) are non-Hodgkin's lymphomas (NHLs) with considerable variation in incidence across the world. They show a wide variety of clinicopathological features and generally associated with poor clinical outcome. Lymphoma data from different geographic regions will definitely aid in routine clinical practice and research work. Read More

    Tissue and serum lipidome shows altered lipid composition with diagnostic potential in mycosis fungoides.
    Oncotarget 2017 May 26. Epub 2017 May 26.
    Department of Biophysics and Structural Biology, Institute of Basic Medical Sciences, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing 100005, China.
    Mycosis fungoides (MF) is the most common type of cutaneous T cell lymphoma. In this study, we used matrix-assisted laser desorption/ionization-Fourier transform ion cyclotron resonance mass spectrometry (MALDI-FTICR-MS) to perform lipidomic profiling of 5 MF tissue samples and 44 serum samples (22 from MF patients and 22 from control subjects). Multivariate statistical analysis of the mass spectral data showed that MF tissues had altered levels of seven lipids and MF sera had altered levels of twelve. Read More

    Associated Hematolymphoid Malignancies in Patients With Lymphomatoid Papulosis: A Canadian Retrospective Study.
    J Cutan Med Surg 2017 Jun 1:1203475417716366. Epub 2017 Jun 1.
    1 Division of Dermatology, University of Toronto, Toronto, ON, Canada.
    Background: Lymphomatoid papulosis is one of the primary cutaneous CD30+ T-cell lymphoproliferative disorders. Although considered a benign disease, lymphomatoid papulosis has been associated potentially with an increased risk of secondary hematolymphoid malignancies.

    Objective: The aim of this study was to assess the clinical characteristics and histologic subtypes of lymphomatoid papulosis, identify the prevalence and types of secondary hematolymphoid malignancies, and determine the potential risk factors for development of these hematolymphoid malignancies. Read More

    Brentuximab vedotin or physician's choice in CD30-positive cutaneous T-cell lymphoma (ALCANZA): an international, open-label, randomised, phase 3, multicentre trial.
    Lancet 2017 06 6. Epub 2017 Jun 6.
    The University of Texas MD Anderson Cancer Center, Houston, TX, USA.
    Background: Cutaneous T-cell lymphomas are rare, generally incurable, and associated with reduced quality of life. Present systemic therapies rarely provide reliable and durable responses. We aimed to assess efficacy and safety of brentuximab vedotin versus conventional therapy for previously treated patients with CD30-positive cutaneous T-cell lymphomas. Read More

    Folliculotropic Mycosis Fungoides with Skewed T-cell Receptor CDR3 motif: Suggestive of Lipid Antigen-selection?
    Acta Derm Venereol 2017 Jun 9. Epub 2017 Jun 9.
    Department of Dermatology, Oslo University Hospital, Rikshospitalet, POB 4950 Nydalen, NO-0424 Oslo, Norway.
    Folliculotropic mycosis fungoides (FMF), a variant of mycosis fungoides (MF) with distinct clinical features, is characterized by infiltration of malignant T cells in hair follicles. This raises the hypothesis that antigens in the hair follicle may contribute to the pathogenesis of FMF. T-cell receptor β gene (TRB) sequences as well as dendritic cell subsets in patients with FMF (n = 21) and control patients with MF (n = 20) were studied to explore this hypothesis. Read More

    CD4(+)CD26(-) lymphocytes are useful to assess blood involvement and define B ratings in cutaneous T cell lymphoma.
    Leuk Lymphoma 2017 Jun 9:1-10. Epub 2017 Jun 9.
    b Drexel University College of Medicine , Philadelphia , PA , USA.
    Bernengo et al. reported that >30% CD4(+)CD26(-) lymphocytes detect blood involvement in patients with mycosis fungoides (MF) and Sézary syndrome. In addition, the ISCL/EORTC suggested that this threshold might serve as a criterion for the B2 blood rating for staging. Read More

    BET bromodomain inhibitor JQ1 decreases CD30 and CCR4 expression and proliferation of cutaneous T-cell lymphoma cell lines.
    Arch Dermatol Res 2017 Aug 7;309(6):491-497. Epub 2017 Jun 7.
    Department of Dermatology, University of Tokyo Graduate School of Medicine, 7-3-1 Hongo, Bunkyo-ku, Tokyo, 113-8655, Japan.
    Bromodomain and external domain (BET) proteins regulate cell growth, proliferation, cell cycle, and differentiation in various cancers. Therefore, they have emerged as interesting targets. The effect of BET inhibitor on cutaneous T-cell lymphoma (CTCL), however, is yet to be known. Read More

    Use of Topical Corticosteroids in Dermatology: An Evidence-based Approach.
    Indian J Dermatol 2017 May-Jun;62(3):237-250
    Department of Dermatology, KPC Medical College and Hospital, Kolkata, West Bengal, India.
    Topical corticosteroids (TCs) are the pillars of dermatotherapeutics. These drugs are the "magic molecules," provided they are used judiciously and appropriately, following a rational prescription. On exhaustive literature search in multiple databases, we found a significant evidence favoring the use of TCs in atopic eczema, localized vitiligo, psoriasis, chronic hand eczema, and localized bullous pemphigoid. Read More

    Extracorporeal photochemotherapy in mycosis fungoides.
    Transfus Clin Biol 2017 May 31. Epub 2017 May 31.
    Department of Hematology & BMT Unit, School of Medicine, Ankara University, Cebeci Hospital, 06590 Ankara, Turkey.
    Objectives: Extracorporeal photo-chemotherapy (ECP, photopheresis) is an approved treatment modality for mycosis fungoides (MF). Our aim is to present our ECP data for MF.

    Methods: We retrospectively evaluated 50 MF patients who received ECP for clinical activity, toxicity, and response and outcome rates, and we compared these with combination therapies. Read More

    Lymphomatoid papulosis associated with chronic lymphocytic leukemia/small lymphocytic lymphoma: 3 cases.
    Br J Dermatol 2017 Jun 1. Epub 2017 Jun 1.
    Department of Dermatology, AP-HP, St Louis Hospital, Paris 7 University, Paris, France.
    Lymphomatoid papulosis (LyP) is considered as an indolent CD30+ lymphoproliferative cutaneous disorder. (1,2) Nevertheless, 10%-20% up to 50% of patients with LyP have coexistent lymphoma. (1, 3-7) The most frequently associated malignancies are mycosis fungoides, primary cutaneous anaplastic large cell lymphoma, or Hodgkin's disease. Read More

    PUVA Induced Bullous Pemphigoid in a Patient with Mycosis Fungoides.
    Case Rep Dermatol Med 2017 16;2017:6134752. Epub 2017 Apr 16.
    Department of Dermatology and Venereology, Akdeniz University School of Medicine, Antalya, Turkey.
    Background. Bullous pemphigoid is an autoimmune subepidermal blistering skin disease in which autoantibodies are directed against components of the basement membrane. The disease primarily affects the elderly people and in most of the patients inducing factors cannot be identified. Read More

    Defining the mimics and clinico-histological diagnosis criteria for mycosis fungoides to minimize misdiagnosis.
    Int J Womens Dermatol 2017 Jun 30;3(2):100-106. Epub 2017 Jan 30.
    Department of Dermatology, Faculty of Medicine, Hospital Hassan II, Fez, Morocco.
    Background: Mycosis fungoides (MF) is a significant diagnostic challenge; it has various differential diagnosis especially at an early stage. Our aim was to describe mimics of MF clinically and histologically, and to define significant diagnostic criteria of the disease.

    Methods: This was a retro-prospective cohort of 370 patients in whom the diagnosis of MF was suspected clinically. Read More

    Psoriasis in patients with Mycosis Fungoides: Α clinicopathological study of 25 patients.
    J Eur Acad Dermatol Venereol 2017 May 30. Epub 2017 May 30.
    "Andreas Sygros" Hospital for skin diseases, Cutaneous Lymphoma Clinic, 5 I. Dragoumi str, 16121, Athens, Greece.
    Background: It has been reported that patients with psoriasis are at increased risk for developing lymphoma including cutaneous T cell lymphomas (CTCL). However, the comorbidity and the histopathologic correlation of psoriasis and Mycosis Fungoides (MF) have been less studied.

    Objective: The objective of the current study was to investigate the relation between mycosis fungoides (MF) and psoriasis. Read More

    Multiple skin cancers in patients with mycosis fungoides after long-term ultraviolet phototherapy.
    Clin Exp Dermatol 2017 Jul 22;42(5):523-526. Epub 2017 May 22.
    Department of Dermatology, Hokkaido University Graduate School of Medicine, Sapporo, Japan.
    Phototherapy is a useful noninvasive therapy, but it can induce cutaneous malignant tumours, including squamous cell carcinoma (SCC) and basal cell carcinoma (BCC). We report on a 79-year-old man who had long-standing mycosis fungoides for 40 years, which had been treated with psoralen ultraviolet A therapy for 37 years at a dose of approximately 5000 J/cm(2) . Approximately 6 years before presentation, numerous types of cutaneous malignancies, including actinic keratosis, BCC and SCC, had begun to develop all over the patient's body. Read More

    Multidisciplinary Management of Mycosis Fungoides/Sézary Syndrome.
    Curr Hematol Malig Rep 2017 Jun;12(3):234-243
    Penn Cutaneous Lymphoma Program, Department of Dermatology, Perelman Center for Advanced Medicine, Perelman School of Medicine at the University of Pennsylvania, 1st Floor South Pavilion, 3400 Civic Center Boulevard, Philadelphia, PA, 19104, USA.
    Purpose Of Review: Diagnosis and management of mycosis fungoides and Sézary syndrome (MF/SS) require accurate clinicopathological correlation and a multidisciplinary approach. We reviewed major advances in the field regarding diagnostic and prognostic tools as well as skin-directed therapies (SDTs) and systemic agents for MF/SS published in the past 2 years.

    Recent Findings: Improved technology (T-cell receptor high-throughput sequencing) and increased multicenter collaboration (Cutaneous Lymphoma International Consortium) have led to diagnostic/prognostic advances. Read More

    Psoriasis mimicking mycosis fungoides clinically.
    Dermatol Online J 2017 May 15;23(5). Epub 2017 May 15.
    Creighton University School of Medicine, Omaha, Nebraska.
    Psoriasis is a complex, chronic immune-mediated inflammatory disease that most commonly presents as well-demarcated erythematous plaques with micaceous scale, affecting roughly 3-4% of the US population [1-4]. Clinically, lesions are often well demarcated thick, scaly, erythematous plaques, characteristically located on the extensor surfaces, such as elbows and knees [1]. In most cases, clinical impression is sufficient to diagnose psoriasis. Read More

    Transformation of Mycosis fungoides/Sezary syndrome: clinical characteristics and prognosis.
    Turk J Haematol 2017 May 23. Epub 2017 May 23.
    Introduction: Transformed mycosis fungoides (T-MF) is a rare variant of mycosis fungoides (MF) with an aggressive course.

    Objectives: In this study we aimed to describe characteristics MF/Sezary syndrome (SS) cases with transformation.

    Materials And Methods: Patients diagnosed with transformed MF (T-MF) among MF/SS patients between 2000 and 2014 in a single center are evaluated retrospectively. Read More

    Harefuah 2016 Oct;155(10):613-615
    The Department of Dermatology, Haemek Medical Center, Afula, Israel.
    Introduction: Unilesional mycosis fungoides is a rare cutaneous T cell lymphoma that warrants either radiation therapy or surgical excision. Benign characteristics result in misdiagnosis, delayed tissue biopsy and subsequently delayed provision of adequate treatment. A young patient presented with a history of 18 months of eczematous benign - appearing single lesion restricted to her index finger. Read More

    Gelling Your Dermatology Nursing Practice: A Practical Guide for Managing the Treatment of Mycosis Fungoides Cutaneous T-Cell Lymphoma With Mechlorethamine Gel.
    J Dermatol Nurses Assoc 2016 May 9;8(3):180-192. Epub 2016 Jun 9.
    Department of Dermatology, University of Pittsburgh Medical Center, Pittsburgh, PA.
    Mycosis fungoides is the most common form of cutaneous T-cell lymphoma. Stage IA and IB mycosis fungoides cutaneous T-cell lymphoma can be effectively controlled by skin-directed therapies such as the mechlorethamine gel approved by the Food and Drug Administration. Dermatology nurses play a key role in promoting good patient compliance through patient education about mycosis fungoides cutaneous T-cell lymphoma disease, proper administration of mechlorethamine gel, and connecting patients with patient assistance programs or other supportive services. Read More

    Clinical characteristics, risk factors and long-term outcome of 114 patients with folliculotropic mycosis fungoides.
    Arch Dermatol Res 2017 Aug 17;309(6):453-459. Epub 2017 May 17.
    Department of Dermatology, MD Anderson Cancer Center, The University of Texas, 1515 Holcombe Blvd, Houston, TX, 77030-4095, USA.
    Folliculotropic mycosis fungoides (FMF) is a distinct variant of mycosis fungoides (MF) where atypical T-cells invade the hair follicles. The objective was to assess the clinical features, risk factors for progression, long-term outcome and response to treatment modalities in a large cohort of FMF patients. We, therefore, conducted a single-center retrospective study, reviewing 114 patients with FMF seen from 1987 to 2015 at the cutaneous T-cell lymphoma clinic of the MD Anderson Cancer Center. Read More

    Successful Treatment of Primary Cutaneous Peripheral T-Cell Lymphoma Presenting Acquired Ichthyosis with Oral Bexarotene Monotherapy.
    Case Rep Oncol 2017 Jan-Apr;10(1):328-332. Epub 2017 Apr 6.
    Department of Dermatology, Tohoku University Graduate School of Medicine, Sendai, Japan.
    Acquired ichthyosis (AI) is a reactive cutaneous manifestation that can be associated with malignant hematological disease, including cutaneous T-cell lymphoma (CTCL). Since it is difficult to distinguish AI from ichthyosiform mycosis fungoides, to select the treatment for CTCL with ichthyosis-like appearance and to evaluate its efficacy is sometimes challenging. In this report, we describe a case of primary cutaneous peripheral T-cell lymphoma not otherwise specified presenting AI successfully treated with oral bexarotene. Read More

    Concomitant B Hairy Cell Leukemia and Mycosis Fungoides in an Elderly Man.
    Case Rep Dermatol 2017 Jan-Apr;9(1):103-107. Epub 2017 Apr 7.
    aDivision of Dermatology, Department of Medicine, University of Alberta, Edmonton, Alberta, Canada.
    The development of both a T- and B-cell lymphoproliferative disorder in one patient is an unlikely coincidence due to the low prevalence of each malignancy. We report a 65-year-old man with a previously documented history of B hairy cell leukemia, who presented with a new-onset acneiform eruption of his scalp, face, trunk, back, and extremities. Routine pathology of the skin lesions with immunohistochemical stains and molecular studies were consistent with a folliculotropic mycosis fungoides. Read More

    Computed Tomography scanning in mycosis fungoides - optimising the balance between benefit and harm.
    Br J Dermatol 2017 May 12. Epub 2017 May 12.
    Department of Dermatology, University Hospitals Birmingham, Mindelsohn Way, Edgbaston, Birmingham, B15 2GW.
    Mycosis fungoides (MF) is the most common form of cutaneous T-cell lymphoma (CTCL), accounting for 55% cases(1) . Although incurable, it most often presents in early-stage with a good prognosis. The primary aim is to minimise symptoms and maximise quality of life. Read More

    Disseminated CD8-positive, CD30-positive cutaneous lymphoproliferative eruption with overlapping features of mycosis fungoides and primary cutaneous anaplastic large cell lymphoma following remote solitary lesional presentation.
    J Cutan Pathol 2017 Aug 13;44(8):703-712. Epub 2017 Jun 13.
    Department of Dermatology, University of Iowa Hospitals and Clinics, Iowa City, Iowa.
    CD8-positive, CD30-positive cutaneous lymphoproliferative disorders constitute a rare subset of T-cell lymphoproliferative conditions, including variants of primary cutaneous anaplastic large cell lymphoma (ALCL), mycosis fungoides, lymphomatoid papulosis type D, cutaneous gamma-delta T-cell lymphoma and cutaneous peripheral T-cell lymphoma. These entities share overlapping clinical, histopathologic and immunophenotypic features, presenting both a clinical and pathological diagnostic challenge. Presented here is a 73-year-old man with a disseminated, indolent CD30+, CD8+ cutaneous lymphoproliferative disorder with overlapping clinical and histopathological features of both mycosis fungoides and primary cutaneous ALCL, as well as features of lymphomatoid papulosis. Read More

    Clinical applications of 3-dimensional printing in radiation therapy.
    Med Dosim 2017 Summer;42(2):150-155. Epub 2017 May 8.
    Department of Medical Physics, Dalhousie University, Queen Elizabeth II Health Sciences Centre, 5820 University Avenue, Halifax, Nova Scotia B3H 2Y9, Canada.
    Three-dimensional (3D) printing is suitable for the fabrication of complex radiotherapy bolus. Although investigated from dosimetric and feasibility standpoints, there are few reports to date of its use for actual patient treatment. This study illustrates the versatile applications of 3D printing in clinical radiation oncology through a selection of patient cases, namely, to create bolus for photon and modulated electron radiotherapy (MERT), as well as applicators for surface high-dose rate (HDR) brachytherapy. Read More

    Comprehensive analysis of cutaneous T-cell lymphoma (CTCL) incidence and mortality in Canada reveals changing trends and geographic clustering for this malignancy.
    Cancer 2017 May 10. Epub 2017 May 10.
    Division of Dermatology, University of Ottawa, Ottawa, Ontario, Canada.
    Background: Previous reports of geographic clustering of cutaneous T-cell lymphoma (CTCL) in Texas, Pittsburgh, and Sweden as well as the occurrence of CTCL in married couples and family members raise a possibility of the existence of an external and potentially preventable trigger(s) for this rare skin cancer.

    Methods: The authors studied CTCL incidence and mortality in Canada using 3 distinct population-based cancer databases. Data on patients' sex, age at the time of diagnosis, subtype of CTCL malignancy, reporting province, city, and postal code were analyzed. Read More

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