3,547 results match your criteria Mycoses[Journal]


Can Intravenous Antifungal therapy be safely used in the Outpatient Parenteral Antimicrobial Therapy (OPAT) setting?

Mycoses 2018 Nov 30. Epub 2018 Nov 30.

Department of Infectious Diseases, Mater Misericordiae University Hospital, Eccles St, Dublin 7, Ireland.

Outpatient parenteral antimicrobial therapy (OPAT) is an established treatment option for patients with a variety of infections who require a period of intravenous therapy, are clinically stable, and do not require continuous monitoring. Many patients with fungal infections require prolonged therapy due to resistance or intolerance to oral antifungal agents. Despite the widespread use of OPAT by infection specialists, antifungal agents appear infrequently used in this setting. Read More

View Article
November 2018
1 Read

Outcome and potentially modifiable risk factors for candidemia in critically ill burns patients: A matched cohort study.

Mycoses 2018 Nov 27. Epub 2018 Nov 27.

AP-HP, Hôpital Saint-Louis, Department of Anesthesiology and Critical Care and Burn Unit, Paris, France.

Background: Patients with extensive burns are at risk of developing candidemia.

Objectives: To identify potentially modifiable risk factors and outcomes of candidemia in critically ill burns patients.

Patients And Methods: Retrospective matched cohort study including adult burns patients. Read More

View Article
November 2018
3 Reads

Managing Liver Dysfunction in Hematology Patients: Switch Antifungals, or use the Tincture of Time?

Mycoses 2018 Nov 26. Epub 2018 Nov 26.

Michigan Medicine Department of Pharmacy and the University of Michigan College of Pharmacy, Ann Arbor, MI, USA.

Liver function test (LFT) abnormalities are a common occurrence in hematology patients receiving antifungal therapies. The cause of elevated LFTs is often multifactorial. Posaconazole is associated with elevated LFTs in approximately 5-10% of patients. Read More

View Article
November 2018

Evaluation of drug susceptibility test for Efinaconazole compared with conventional antifungal agents.

Mycoses 2018 Nov 14. Epub 2018 Nov 14.

Department of Dermatology, Konkuk University School of Medicine, Seoul, Korea.

Background: Superficial fungal infections are one of the most common and burdensome skin problems affecting quality of life in patients. Various conventional antifungal agents have been used to treat fungal infections; however, various problems have been reported including drug interaction, drug resistance and low effectiveness. Efinaconazole is a novel antifungal agent, which has proven to be particularly effective against onychomycosis compared with conventional antifungal agents. Read More

View Article
November 2018
1 Read

Developing definitions for invasive fungal diseases in critically ill adult patients in intensive care units.Protocol of the FUNgal infections Definitions in ICU patients (FUNDICU) project.

Mycoses 2018 Nov 13. Epub 2018 Nov 13.

Infectious Diseases Service, Department of Medicine, Lausanne University, Lausanne, Switzerland.

Background: The reliability of diagnostic criteria for invasive fungal diseases (IFD) developed for severely immunocompromised patients is questionable in critically-ill adult patients in intensive care units (ICU).

Objectives: To develop a standard set of definitions for IFD in critically-ill adult patients in ICU.

Methods: Based on a systematic literature review, a list of potential definitions to be applied to ICU patients will be developed by the ESCMID Study Group for Infections in Critically Ill Patients (ESGCIP) and the ESCMID Fungal Infection Study Group (EFISG) chairpersons. Read More

View Article
November 2018
3 Reads

First-time isolation and quantification of Basidiobolus spp. from reptile faeces in KwaZulu-Natal (South Africa) using selective media.

Mycoses 2018 Nov 8. Epub 2018 Nov 8.

Discipline of Microbiology, School of Life Sciences, University of KwaZulu-Natal, Pietermaritzburg, South Africa.

Members of the genus Basidiobolus are potentially pathogenic fungi, known to cause mycoses in tropical and subtropical countries. Basidiobolus spp. can be associated with animals, and reptiles and amphibians are candidate vectors for the distribution of this fungus. Read More

View Article
November 2018
3 Reads

False positive bronchoalveolar lavage galactomannan: Effect of host and cut-off value.

Mycoses 2018 Nov 1. Epub 2018 Nov 1.

Brigham and Women's Hospital, Rhode Island Hospital, Division of Infectious Diseases, Harvard Medical School, Boston, Massachusetts.

Objectives: Bronchoalveolar lavage galactomannan (BAL-GM) is a mycological criterion for diagnosis of probable invasive aspergillosis (IA) per European Organization for Research and Treatment of Cancer/Mycoses Study Group (EORT-MSG) consensus criteria, but its real-world positive predictive value (PPV) has not been well-studied. Our aim was to estimate the PPV of BAL-GM in a contemporary cohort of patients with positive BAL-GM.

Methods: We identified consecutive patients with ≥1 positive BAL-GM value (index ≥ 0. Read More

View Article
November 2018
2 Reads

Perspectives on misidentification of Trichophyton interdigitale/Trichophyton mentagrophytes using internal transcribed spacer region sequencing: Urgent need to update the sequence database.

Mycoses 2018 Oct 26. Epub 2018 Oct 26.

Department of Medical Microbiology and Infectious Diseases, Canisius-Wilhelmina Hospital, Nijmegen, The Netherlands.

The taxonomy of the dermatophytes has been revisited using a novel multilocus phylogenetic approach, and several neotypes and reference strains have been assigned for Trichophyton species. Single gene sequencing, that is the ITS region, for identification of highly related species T. mentagrophytes/T. Read More

View Article
October 2018
1 Read
1.800 Impact Factor

DC-SIGN and VDR polymorphisms are associated with chronic form of paracoccidioidomycosis with oral manifestations.

Mycoses 2018 Oct 26. Epub 2018 Oct 26.

Departamento de Microbiologia e Imunologia, Universidade Federal de Alfenas, Alfenas, MG, Brazil.

Paracoccidioidomycosis (PCM) is a granulomatous disease caused by fungi of the species complex of the Paracoccidioides genus. One of the main clinical manifestations of PCM is the presence of oral lesions with the presence of epithelioid granulomas. In this work, we aimed to evaluate the frequency of SNPs in the TNF-α, JAK1, VDR, DC-SIGN and FcγRIIa genes in patients with chronic PCM and verify possible association of these SNPs with the organisation pattern of the granulomas in the oral lesions. Read More

View Article
October 2018
1 Read

Exserohilum infections in Australian Queensland children.

Mycoses 2018 Oct 23. Epub 2018 Oct 23.

Infection Management and Prevention Service, Queensland Children's Hospital, Brisbane, Queensland, Australia.

Background: Exserohilum species are environmental moulds that can cause skin infection and sinusitis in both normal and immunosuppressed children. This study reviews paediatric cases of Exserohilum infection in Queensland, Australia, to identify the spectrum of disease and its clinical course.

Methods: All culture-positive samples of Exserohilum species in children <18 years of age were identified from the Queensland Health Laboratory database (April 2003-April 2018). Read More

View Article
October 2018
5 Reads

Genotypic diversity and antifungal susceptibility of Cryptococcus neoformans isolates from paediatric patients in China.

Mycoses 2018 Oct 19. Epub 2018 Oct 19.

Department of Dermatology, Changzheng Hospital, Second Military Medical University, Shanghai, China.

Cryptococcosis is a life-threatening mycosis primarily occurring in adult patients particularly those with immunosuppression such as HIV infection/AIDS. The number of reported cases of paediatric cryptococcosis has increased in the last decade around the world, including China. However, current information on the characteristics of cryptococcosis in children, particularly the genotypic diversity and antifungal susceptibility of the isolates, is limited. Read More

View Article
October 2018
2 Reads
1.800 Impact Factor

Invasive mucormycosis in children with cancer: A retrospective study from the Infection Working Group of Italian Pediatric Hematology Oncology Association.

Mycoses 2018 Oct 18. Epub 2018 Oct 18.

Pediatric Hematology Oncology, Azienda Ospedaliera Universitaria Integrata, Verona, Italy.

Background: Invasive mucormycosis is a rare but frequently fatal fungal disease. The acute and rapidly progressive evolution causes unfavourable outcome in 22%-59% of patients and its treatment represents a clinical challenge, especially in immunocompromised patients. Current data in paediatric oncological patients are limited. Read More

View Article
October 2018
3 Reads
1.800 Impact Factor

A human subcutaneous infection by Microascus ennothomasiorum sp. nov.

Mycoses 2018 Oct 18. Epub 2018 Oct 18.

Unitat de Micologia, Facultat de Medicina i Ciències de la Salut and IISPV, Universitat Rovira i Virgili, Reus, Spain.

A 60-year-old woman presented with a nodular granulomatous skin lesion on her right thumb. It had developed after inoculation of a splinter of wood. Because it was resistant to various therapies, the nodule was finally excised. Read More

View Article
October 2018

Diagnostic workout to assess early response indicators in invasive pulmonary aspergillosis in adult patients with hematologic malignancies.

Mycoses 2018 Oct 17. Epub 2018 Oct 17.

Department of Internal Medicine-Hematology and Oncology, Mannheim University Hospital, Heidelberg University, Theodor-Kutzer-Ufer 1-3, D-68167, Mannheim, Germany.

In immunocompromised patients with acute leukaemia as well as in allogeneic hematopoietic stem cell transplant patients, pulmonary lesions are commonly seen. Existing guidelines provide useful algorithms for diagnostic procedures and treatment options, but they do not give recommendations on how to evaluate early success or failure and if or when it is best to change therapy. Here we review the diagnostic techniques currently used in association with clinical findings and propose an approach using a combination of computer tomography, clinical and all available biomarkers and inflammation parameters, especially those positive at baseline, to assess early response in invasive pulmonary aspergillosis. Read More

View Article
October 2018
7 Reads

Prevalence of low inflammatory tinea genitalis in southern China.

Mycoses 2018 Oct 11. Epub 2018 Oct 11.

Department of Dermatology, Third Affiliated Hospital, Sun Yat-sen University, Guangzhou, China.

Background: Emergence of highly inflammatory genital dermatophyte infections has been reported from Southeast Asia. In view of this, knowledge of the non-outbreak fungal flora of the genitals is required as a baseline study.

Objectives: We present our 12-year experience in a tertiary clinic with the diagnosis of scrotal fungal infections. Read More

View Article
October 2018
1 Read

Rhodotorula species infections in humans: A systematic review.

Mycoses 2018 Sep 29. Epub 2018 Sep 29.

Department of Internal Medicine & Infectious Diseases, University Hospital of Heraklion, Heraklion, Greece.

Background: Fungal infections by Rhodotorula species are increasingly reported in the literature and consist of bloodstream infections, especially in patients with central venous catheters (CVC), as well as central nervous system (CNS), ocular and other less frequent infections.

Objectives: The aim of this systematic review was to record and evaluate all available evidence regarding infections by Rhodotorula species.

Methods: Systematic review of PubMed (through 9 August 2017) for studies providing epidemiological, clinical, microbiological, as well as treatment data and outcomes of Rhodotorula species infections. Read More

View Article
September 2018

Micafungin may be safely administered as outpatient parenteral antimicrobial therapy for chronic pulmonary aspergillosis.

Mycoses 2018 Sep 29. Epub 2018 Sep 29.

ECMM Centre of Excellence in Clinical and Laboratory Mycology and Clinical Studies, The National Aspergillosis Centre, Wythenshawe Hospital, Manchester University NHS Foundation Trust, Manchester, UK.

Background: Intravenous micafungin has been reported as a treatment alternative in patients with chronic pulmonary aspergillosis (CPA) where long-term oral triazole therapy is unfeasible.

Objectives: We evaluated the safety and efficacy of micafungin administered via the outpatient parenteral antimicrobial therapy (OPAT) service for the treatment of CPA.

Methods: We included all CPA patients who received micafungin via OPAT between April 2016 and March 2018. Read More

View Article
September 2018
1.800 Impact Factor

Epidemiology of Aspergillus species causing keratitis in Mexico.

Mycoses 2018 Sep 26. Epub 2018 Sep 26.

Laboratory of Microbiology, Asociacion para Evitar la Ceguera en Mexico Hospital "Dr. Luis Sanchez-Bulnes", Coyoacán, Mexico.

Background: The incidence of fungal keratitis has increased in recent years. While the epidemiology and clinical roles of various Candida and Fusarium species have been relatively well-identified in infections of the eye, data regarding keratitis caused by Aspergillus species are scant. Accurate and rapid diagnosis is important for successful management of this infection. Read More

View Article
September 2018

Molecular identification and antifungal susceptibility of clinical fungal isolates from onychomycosis (uncommon and emerging species).

Mycoses 2018 Sep 25. Epub 2018 Sep 25.

Department of Medical Mycology, Invasive Fungi Research Center, School of Medicine, Mazandaran University of Medical Sciences, Sari, Iran.

Onychomycosis is a common nail problem, accounting for up to 50% of all nail diseases. The aim of the present study was to determine the species distribution based on the restriction fragment length polymorphism and susceptibility patterns of the causative agents of onychomycosis. This cross-sectional study was conducted on nail samples collected from 257 patients suspected of onychomycosis during 14 months. Read More

View Article
September 2018
3 Reads
1.800 Impact Factor

The epidemiology of non-Candida yeast isolated from blood: The Asia Surveillance Study.

Mycoses 2018 Sep 19. Epub 2018 Sep 19.

Division of Infectious Diseases, Department of Internal Medicine, National Taiwan University Hospital and College of Medicine, Taipei, Taiwan.

Background: Current guidelines recommend echinocandins as first-line therapy for candidemia. However, several non-Candida yeast are non-susceptible to echinocandins (echinocandin non-susceptible yeast, ENSY), including Cryptococcus, Geotrichum, Malassezia, Pseudozyma, Rhodotorula, Saprochaete, Sporobolomyces and Trichosporon. In laboratories that are not equipped with rapid diagnostic tools, it often takes several days to identify yeast, and this may lead to inappropriate presumptive use of echinocandins in patients with ENSY fungemia. Read More

View Article
September 2018
7 Reads

Cutaneous infections by dematiaceous opportunistic fungi: Diagnosis and management in 11 solid organ transplant recipients.

Mycoses 2018 Sep 19. Epub 2018 Sep 19.

Department of Dermatology, Hospital Universitari Vall d'Hebron, Barcelona, Spain.

Background: The incidence of cutaneous infections by dematiaceous fungi is rising in our environment due to the high number of solid organ transplant recipients (SOTR).

Objective: To review our experience in the management of cutaneous phaeohyphomycoses in a Spanish reference centre for dermatological care of SOTR.

Methods: Retrospective clinical, histopathological and microbiological review of all SOTR diagnosed of a phaeohyphomycosis in a 7-year period. Read More

View Article
September 2018

Tolerability of isavuconazole after posaconazole toxicity in leukaemia patients.

Mycoses 2018 Sep 19. Epub 2018 Sep 19.

Department of Infectious Diseases Infection Control and Employee Health, University of Texas MD Anderson Cancer Center, Houston, Texas.

Background: Posaconazole (PCZ) is widely used for prophylaxis or treatment of invasive fungal infections (IFIs) in leukaemia patients. However, issues with PCZ tolerability can result in treatment interruption. Isavuconazole (ISA) has a similar broad spectrum of activity to PCZ; however, real-world data regarding the tolerability of ISA after PCZ toxicity are lacking. Read More

View Article
September 2018
3 Reads

Arthroderma chiloniense sp. nov. isolated from human stratum corneum: Description of a new Arthroderma species.

Mycoses 2018 Sep 11. Epub 2018 Sep 11.

Institut für Mikrobiologie und Hygiene, Universitätsmedizin Berlin - Charité, Berlin, Germany.

A 68-year-old woman was submitted to our hospital because of erythematous and scaly skin lesions. To exclude tinea samples of stratum corneum were collected and used for mycological investigations. In this material, no fungal elements were detected microscopically, but inoculation on Sabouraud agar with cycloheximide yielded a presumptive dermatophyte fungus. Read More

View Article
September 2018
2 Reads

Identification and biofilm development by a new fungal keratitis aetiologic agent.

Mycoses 2018 Sep 6. Epub 2018 Sep 6.

Departamento de Microbiología y Proteómica, Instituto de Oftalmología "Fundación Conde de Valenciana", Mexico City, México.

Background: In recent years, human keratitis caused by fungal plant pathogens has become more common. Biofilm is a structure that confers adaptations and virulence to fungi in keratitis. Neoscytalidium spp. Read More

View Article
September 2018
6 Reads
1.800 Impact Factor

A clarion call for preventing taxonomical errors of dermatophytes using the example of the novel Trichophyton mentagrophytes genotype VIII uniformly isolated in the Indian epidemic of superficial dermatophytosis.

Mycoses 2018 Sep 6. Epub 2018 Sep 6.

Institut für Mikrobiologie und Hygiene, Nationales Konsiliarlabor für Dermatophyten, Universitätsmedizin Berlin - Charité, Berlin, Germany.

An alarming pan Indian increase in the incidence of superficial dermatophytosis has been noticed over the past 5-6 years. Recent studies have demonstrated emerging predominance of Trichophyton (T.) mentagrophytes as the causative organism in such cases. Read More

View Article
September 2018
2 Reads

The role of medical mycology societies in combating invasive fungal infections in low- and middle-income countries: A Nigerian model.

Mycoses 2018 Sep 5. Epub 2018 Sep 5.

Global Action Fund for Fungal Infections, Geneva, Switzerland.

The discipline of medical mycology has become increasingly relevant in the face of the rising incidence of invasive fungal infections (IFI), which pose diagnostic and therapeutic challenges for contemporary medical practice. While firmly established in developed countries, medical mycology remains obscure in many low- and middle-income countries (LMICs). With a teeming vulnerable populace and an incidence rate of 11. Read More

View Article
September 2018
8 Reads

Cyberlindnera fabianii fungaemia outbreak in preterm neonates in Kuwait and literature review.

Mycoses 2018 Sep 5. Epub 2018 Sep 5.

Department of Microbiology, Faculty of Medicine, Kuwait University, Safat, Kuwait.

Background: Cyberlindnera fabianii has rarely been reported as a human pathogen. Here, we describe an outbreak of C. fabianii fungaemia involving 10 preterm neonates during a seven-month period in Kuwait and review the published reports. Read More

View Article
September 2018
8 Reads

Fluconazole resistance is not a predictor of poor outcome in patients with cryptococcosis.

Mycoses 2018 Sep 5. Epub 2018 Sep 5.

Clinical Microbiology and Infectious Diseases, Hospital General Universitario Gregorio Marañón.

Background: Cryptococcus isolates with high MICs to fluconazole are increasingly reported and a potential clinical impact has been advocated. However, there are different methods to evaluate fluconazole MICs and comparative analysis among such techniques and their comprehensive correlation with clinical outcome are not available.

Methods: Over a 13-year period (2000-2013), fluconazole MICs were determined for 62 cryptococcal isolates recovered from 22 patients with cryptococcosis using CLSI M27-A3, EUCAST, E-test and Sensititre YeastOne, simultaneously. Read More

View Article
September 2018
9 Reads

Detection of Trichophyton rubrum and Trichophyton interdigitale in onychomycosis using monoclonal antibodies against Sub6 (Tri r 2).

Mycoses 2018 Aug 28. Epub 2018 Aug 28.

Department of Dermatology, Centre Hospitalier Universitaire Vaudois, Lausanne, Switzerland.

Background: Onychomycosis is the most prevalent nail disease and is mainly caused by two dermatophyte species Trichophyton rubrum and Trichophyton interdigitale with a frequency in the range of 80% and 20%, respectively. The secreted protease Sub6 of the subtilisin family, which was never detected in vitro growth conditions, was found to be a robust marker of onychomycosis.

Objective: The aim of this work was to detect tinea unguium using anti-Sub6 monoclonal antibodies in proteins extracted from clinical nail samples. Read More

View Article
August 2018
14 Reads

In vitro susceptibility of Microsporum spp. and mammalian cells to Eugenia caryophyllus essential oil, eugenol and semisynthetic derivatives.

Mycoses 2018 Aug 24. Epub 2018 Aug 24.

Facultad de Química Ambiental, Grupo de Investigaciones Ambientales para el Desarrollo Sostenible, Universidad Santo Tomás, Bucaramanga, Colombia.

Background: Microsporum spp. are keratinophilic dermatophytes that mainly invade the stratum corneum of the skin and hair causing clinical symptoms associated with tinea. Its treatment has several limitations, and the search for new active molecules is necessary. Read More

View Article
August 2018
2 Reads

In vitro detection of Candida and Aspergillus antigen in parenteral nutrition and fixed combinations of piperacillin-tazobactam.

Mycoses 2018 Aug 14. Epub 2018 Aug 14.

Klinik-Apotheke, Universitätsklinikum Carl Gustav Carus an der Technischen Universität Dresden, Dresden, Germany.

Background: Screening for Aspergillus (Asp-AG) and Candida antigen (Ca-AG) with immunoassays is established for stem cell recipients at high risk for invasive fungal infections (IFI). While parenteral nutrition (PN) will be applied in case of complications leading to insufficient alimentation, piperacillin-tazobactam (TZP) is started at the onset of febrile neutropenia.

Objectives: The aim of this study was to investigate drug-laboratory interactions between PN and TZP and both immunoassays which could affect the specificity of the assays and lead to the false assumption of an IFI. Read More

View Article
August 2018
1 Read

Estimated burden of serious human fungal diseases in Turkey.

Mycoses 2018 Aug 14. Epub 2018 Aug 14.

The National Aspergillosis Centre, Wythenshawe Hospital, The University of Manchester, Manchester Academic Health Science Centre, Manchester, UK.

The current number of fungal infections occurring each year in Turkey is unknown. We estimated the burden of serious human fungal diseases based on the population at risk, existing epidemiological data from 1920 to 2017 and modelling previously described by the LIFE program (http://www.LIFE-worldwide. Read More

View Article
August 2018
11 Reads

MGL_3741 gene contributes to pathogenicity of Malassezia globosa in pityriasis versicolor.

Mycoses 2018 Aug 14. Epub 2018 Aug 14.

Department of Medical Mycology & Parasitology, School of Public Health, Tehran University of Medical Sciences, Tehran, Iran.

Dihydroxyacid dehydratase (DHAD) is a key enzyme in biosynthetic pathway of isoleucine and valine. This pathway is absent in human but exists in various organisms such as fungi. Using RNA-seq analysis in this study, we identified MGL_3741gene which encodes DHAD protein in Malassezia globosa (M. Read More

View Article
August 2018
7 Reads

An experimental murine model of otitis and dermatitis caused by Malassezia pachydermatis.

Mycoses 2018 Aug 14. Epub 2018 Aug 14.

Programa de Pós-Graduação em Farmacologia, Centro de Ciências da Saúde, Universidade Federal de Santa Maria (UFSM), Santa Maria, Rio Grande do Sul, Brasil.

We report a malasseziosis model in immunocompromised Swiss mice. For this model, the mice were immunosuppressed with a combination of cyclophosphamide at 150 mg/kg and hydrocortisone acetate at 250 mg/kg. Two groups were formed according to the site of inoculation. Read More

View Article
August 2018
6 Reads

Diagnosis of invasive fungal diseases in haematology and oncology: 2018 update of the recommendations of the infectious diseases working party of the German society for hematology and medical oncology (AGIHO).

Mycoses 2018 Nov 3;61(11):796-813. Epub 2018 Sep 3.

Department of Internal Medicine IV, Universitätsklinik Halle, Halle, Germany.

Invasive fungal diseases (IFD) are a primary cause of morbidity and mortality in patients with haematological malignancies. These infections are mostly life-threatening and an early diagnosis and initiation of appropriate antifungal therapy are essential for the clinical outcome. Most commonly, Aspergillus and Candida species are involved. Read More

View Article
November 2018
12 Reads

Identification of Mucorales in patients with proven invasive mucormycosis by polymerase chain reaction in tissue samples.

Mycoses 2018 Aug 9. Epub 2018 Aug 9.

Department of Medical Mycology, School of Medicine, Mazandaran University of Medical Sciences, Sari, Iran.

Background: Accurate diagnosis of mucormycosis, a life-threatening fungal infection, remains a challenge for physicians.

Objectives: To identify the causative Mucorales in fresh clinical samples and formalin-fixed paraffin-embedded (FFPE) samples of patients with proven mucormycosis by molecular method.

Patients/methods: Fresh clinical samples of patients with proven mucormycosis according to the EORTC/MSG criteria admitted between 2015 and 2017 and histopathologically proven FFPE archives collected during 2004-2007 and 2015-2017 from Mazandaran University-affiliated hospitals of northern Iran were included. Read More

View Article
August 2018
9 Reads

Global guidelines and initiatives from the European Confederation of Medical Mycology to improve patient care and research worldwide: New leadership is about working together.

Mycoses 2018 Nov 28;61(11):885-894. Epub 2018 Aug 28.

CECAD Cluster of Excellence, University of Cologne, Cologne, Germany.

Invasive mycoses present a global challenge with expansion into new hosts, emergence of new pathogens, and development of multidrug resistance. In parallel, new antifungal agents and advanced laboratory diagnostic systems are being developed. In response to these evolving challenges, the European Confederation of Medical Mycology (ECMM) is committed to providing international expertise, guidance, and leadership with the key objectives of improving diagnosis, treatment, outcome, and survival of persons with invasive fungal diseases. Read More

View Article
November 2018
13 Reads

Internal validation of GPS MONODOSE CanAur dtec-qPCR kit following the UNE/EN ISO/IEC 17025:2005 for detection of the emerging yeast Candida auris.

Mycoses 2018 Nov 20;61(11):877-884. Epub 2018 Aug 20.

Department of Medical Microbiology and Infectious Diseases, ECMM Excellence Center, Canisius-Wilhelmina Hospital (CWZ), Nijmegen, The Netherlands.

Candida auris is an emerging multidrug resistant pathogenic fungus that causes candidaemia with high mortality rates and exhibits the ability to persist within the hospital environment. Candida auris is phylogenetically closely related to Candida haemulonii, C. lusitaniae, C. Read More

View Article
November 2018

Banana blossom agar (BABA), a new medium to isolate members of the Cryptococcus neoformans/Cryptococcus gattii species complex useful for resource limited countries.

Mycoses 2018 Jul 26. Epub 2018 Jul 26.

Westerdijk Fungal Biodiversity Institute, Utrecht, The Netherlands.

Isolation of representatives of the Cryptococcus neoformans/Cryptococcus gattii species complex can be made using dopamine containing media, such as Niger seed agar and l-DOPA agar. Here, we describe an alternative medium that uses banana flowers. Banana is a dopamine containing fruit and is widely available in tropical and subtropical countries that have high numbers of cryptococcosis patients. Read More

View Article
July 2018
2 Reads

Treatment outcomes in patients with proven/probable vs possible invasive mould disease in a phase III trial comparing isavuconazole vs voriconazole.

Mycoses 2018 Nov 13;61(11):868-876. Epub 2018 Aug 13.

University of Würzburg Medical Center, Würzburg, Germany.

Treatment outcomes in patients with proven/probable vs possible invasive mould disease (IMD; 2008 European Organisation for Research and Treatment of Cancer/Mycoses Study Group [EORTC/MSG] criteria) needed further assessment. The Phase III SECURE trial compared isavuconazole vs voriconazole for treatment of IMD. This post hoc analysis assessed all-cause mortality (ACM) through day 42 (primary endpoint) and day 84, overall and clinical success at end of treatment (EOT), and drug-related treatment-emergent adverse events (TEAEs) in subgroups with proven/probable or possible IMD. Read More

View Article
November 2018
7 Reads

Tinea corporis by Microsporum canis in mycological laboratory staff: Unexpected results of epidemiological investigation.

Mycoses 2018 Jul 21. Epub 2018 Jul 21.

State Veterinary Laboratory, Lublin, Poland.

Microsporum canis is a zoophilic dermatophyte, which is very contagious, especially to cats and dogs. Asymptomatic animal carriers of M. canis are regarded a critical factor in the epidemiology of the disease. Read More

View Article
July 2018
3 Reads

Mixed mold pulmonary infections in haematological cancer patients in a tertiary care cancer centre.

Mycoses 2018 Nov 1;61(11):861-867. Epub 2018 Aug 1.

Department of Infectious Disease, Infection Control and Employee Health, The University of Texas MD Anderson Cancer Center, Houston, Texas.

There is a paucity of data regarding mixed mold pulmonary infections (MMPIs) in patients with haematological malignancies with or without haematopoietic stem cell transplantation (HSCT). We retrospectively studied 27 such patients (2005-2015) and compared them to patients with invasive pulmonary aspergillosis (IPA) caused by Aspergillus fumigatus. Factors associated with the diagnosis of MMPIs were significant corticosteroid use [20 (74%) vs 6 (22%), P < 0. Read More

View Article
November 2018
14 Reads

Sexual behaviour and extra-genital colonisation in women treated for recurrent Candida vulvo-vaginitis.

Mycoses 2018 Nov 1;61(11):857-860. Epub 2018 Aug 1.

Femicare vzw, Tienen, Belgium.

Objective: This study analyses a relation between sexual habits and the presence of Candida in extra-genital locations as well as a potential effect on therapy response.

Material And Methods: Candida cultures were obtained from mouth, nose, anus, urine and perineum of 117 women enrolled in a RVVC treatment trial (ReCiDiF). Sexual behaviour and carriage rates of extra-genital Candida of women responding well to treatment were compared to that of non-responders. Read More

View Article
November 2018
7 Reads

In vitro interactions between 17-AAG and azoles against Exophiala dermatitidis.

Mycoses 2018 Nov 27;61(11):853-856. Epub 2018 Jul 27.

Department of Dermatology, Jingzhou Central Hospital, The Second Clinical Medical College, Yangtze University, Jingzhou, China.

Background: Exophiala dermatitidis causes a variety of illnesses in humans which are always refractory to available treatment modalities. Hsp90 governs crucial stress responses, cell wall repair mechanisms and antifungal resistance in pathogenic fungi. Thus, targeting Hsp90 with specific inhibitors holds considerable promise as combination strategy. Read More

View Article
November 2018
4 Reads

Fungal keratitis: An overview of clinical and laboratory aspects.

Mycoses 2018 Jul 11. Epub 2018 Jul 11.

Department of Ocular Trauma and Emergency, Farabi Eye Hospital, Tehran University of Medical Sciences, Tehran, Iran.

Mycotic keratitis or keratomycosis is a fungal infection with global distribution. The dominant aetiology of this disease varies based on geographical origin, socioeconomic status, and climatic condition. Generally, Aspergillus spp. Read More

View Article
July 2018
37 Reads

Genetic diversity of Pneumocystis jirovecii from a cluster of cases of pneumonia in renal transplant patients: Cross-sectional study.

Mycoses 2018 Nov 27;61(11):845-852. Epub 2018 Jul 27.

Special Mycology Laboratory, Division of Infectious Diseases, Department of Medicine, Universidade Federal de São Paulo (UNIFESP), São Paulo, SP, Brazil.

Pneumocystis jirovecii can cause severe potentially life-threatening pneumonia (PCP) in kidney transplant patients. Prophylaxis of patients against PCP in this setting is usually performed during 6 months after transplantation. The aim of this study is to describe the molecular epidemiology of a cluster of PCP in renal transplant recipients in Brazil. Read More

View Article
November 2018
15 Reads
1.800 Impact Factor

Assessment of a pan-dermatophyte nested-PCR compared with conventional methods for direct detection and identification of dermatophytosis agents in animals.

Mycoses 2018 Nov 11;61(11):837-844. Epub 2018 Jul 11.

Infectious and Tropical Diseases Research Center, Health Research Institute, Ahvaz Jundishapur University of Medical Sciences, Ahvaz, Iran.

Conventional direct microscopy with potassium hydroxide (KOH) and culture were found to lack the ability to establish a fast and specific diagnosis of dermatophytosis. A pan-dermatophyte nested-PCR assay was developed using a novel primer pair targeting the translation elongation factor 1-α (Tef-1α) sequences for direct detection and identification of most veterinary relevant dermatophytes in animal samples suspected to dermatophytosis. A total of 140 animal skin and hair samples were subjected to direct microscopy, culture, and ITS-RFLP/ITS-sequencing of culture isolates for the detection and identification of dermatophytosis agents. Read More

View Article
November 2018
1 Read

EQUAL Aspergillosis Score 2018: An ECMM score derived from current guidelines to measure QUALity of the clinical management of invasive pulmonary aspergillosis.

Mycoses 2018 Nov 13;61(11):833-836. Epub 2018 Jul 13.

Department I for Internal Medicine, Excellence Center for Medical Mycology (ECMM), University of Cologne, Cologne, Germany.

Invasive pulmonary aspergillosis is a serious threat to immunocompromised and critical care patients. Recent detailed guidelines and treatment algorithms lead microbiologists and clinicians in diagnosis and treatment of invasive aspergillosis. Currently, there is no tool available that allows to measure guideline adherence. Read More

View Article
November 2018
1 Read

Cryptic Aspergillus from clinical samples in the USA and description of a new species in section Flavipedes.

Mycoses 2018 Nov 11;61(11):814-825. Epub 2018 Jul 11.

Unitat de Micologia, Facultat de Medicina i Ciències de la Salut, IISPV, Universitat Rovira i Virgili, Reus, Spain.

Background: In the last few decades there has been an emergence of cryptic Aspergillus as agents of human infections due to the increase in immunocompromised population and to the improvement of identification tools.

Methods: Continuing our study on Aspergillus isolates from clinical origin deposited in a mycological reference centre in the United States, we selected 37 isolates belonging to less common sections of the genus, to study their species diversity and detect cryptic species by using a polyphasic approach.

Results: From this set of isolates, a total of 16 species were identified; the most frequent being A. Read More

View Article
November 2018
2 Reads