3,576 results match your criteria Mycoses[Journal]


Killing of Candida auris by UV-C: importance of exposure time and distance.

Mycoses 2019 Feb 12. Epub 2019 Feb 12.

Department of Medical Microbiology and Infectious Diseases, Canisius Wilhelmina Hospital (CWZ), Nijmegen, The Netherlands.

Background: Candida auris is a globally emerging yeast, causing severe infections in patients with underlying diseases. This yeast is responsible for several outbreaks within healthcare facilities, where it can be found on hospital surfaces and patient care devices. Spread from these fomites may be prevented by improving the decontamination of hospital surfaces. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1111/myc.12903DOI Listing
February 2019

Can urinary histoplasma antigen test improve the diagnosis of histoplasmosis in a tuberculosis endemic region?

Mycoses 2019 Feb 8. Epub 2019 Feb 8.

Microbiology Post Graduate Institute of Medical Education and Research, Chandigarh, India.

Background: Many patients with histoplasmosis are treated with anti-tubercular therapy (ATT) in tuberculosis endemic regions as diagnosis of histoplasmosis requires invasive sampling. We sought to study the utility of urinary Histoplasma antigen detection test.

Methods: Case records of patients with a diagnosis of histoplasmosis prior to (Period A) and after (Period B) introduction of urinary Histoplasma antigen detection test were analysed in this single centre retrospective study RESULTS: Thirty seven patients (18 in period A, and 19 patients in period B) were studied. Read More

View Article

Download full-text PDF

Source
http://doi.wiley.com/10.1111/myc.12902
Publisher Site
http://dx.doi.org/10.1111/myc.12902DOI Listing
February 2019
4 Reads

Outcomes of patients with invasive fusariosis who undergo further immunosuppressive treatments, is there a role for secondary prophylaxis?

Mycoses 2019 Feb 5. Epub 2019 Feb 5.

Division of Infectious Diseases, Brigham and Women's Hospital, Harvard Medical School, 75 Francis St, Boston, MA, USA.

Background: Patients treated for invasive aspergillosis may relapse during subsequent periods of immunosuppression and should receive secondary prophylaxis. Little is known about the frequency of relapse and practices of secondary prophylaxis for invasive fusariosis (IF).

Objectives: Evaluate practices of secondary prophylaxis and the frequency of relapse in patients who survived IF and were exposed to subsequent periods of immunosuppression. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1111/myc.12901DOI Listing
February 2019
1 Read

Species distribution and epidemiological characteristics of superficial fungal infections in Southeastern Serbia.

Mycoses 2019 Jan 28. Epub 2019 Jan 28.

Department of Microbiology and Immunology, Faculty of Medicine, University of Belgrade, Serbia, Dr Subotica 1, 11000, Belgrade, Serbia.

Background: Superficial fungal infections (SFI), one of the most prevalent diseases in the world, are infections of keratin-rich structures of human body mostly caused by dermatophytes and yeasts.

Objectives: The goal of this study was to determine the possible changes in the epidemiology of SFI on the territory of Southeastern Serbia and to investigate epidemiological characteristics and the influence of SFI on the patient's quality of life.

Methods: From 2012 to the end of 2017, samples of 1643 patients (568 males and 1075 females, mean age 40. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1111/myc.12900DOI Listing
January 2019

A pharmacokinetic model for voriconazole in a highly diversified population of children and adolescents with cancer.

Mycoses 2019 Jan 28. Epub 2019 Jan 28.

Pediatric Oncology Department, GRAACC/IOP/UNIFESP, and Pediatric Department, UNIFESP.

Background: The wide pharmacokinetic variability of voriconazole leads to uncertainty regarding adequate exposure.

Objectives: To create a pharmacokinetic model that could help to explain the variability.

Methods: Retrospective review of pediatric patients with cancer. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1111/myc.12899DOI Listing
January 2019
1 Read

Mucormycosis- a clinicoepidemiological review of cases over 10 years.

Mycoses 2019 Jan 27. Epub 2019 Jan 27.

Christian Medical College, Vellore, Tamil Nadu, India, 629004.

Background: Limited data exists for epidemiology and outcomes of various agents causing mucormycosis in various clinical settings from developing countries like India.

Objectives: To study the epidemiology and outcomes of various agents causing mucormycosis in different clinical settings in a tertiary care hospital from South India.

Patients And Methods: We reviewed details of 184 consecutive patients with culture proven mucormycosis with consistent clinical syndrome and supporting features from September 2005 to September 2015. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1111/myc.12897DOI Listing
January 2019
5 Reads

Airway Colonization by Candida and Aspergillus species in Iranian Cystic Fibrosis Patients.

Mycoses 2019 Jan 25. Epub 2019 Jan 25.

Department of Medical Mycology/ Invasive Fungi Research Center, School of Medicine, Mazandaran University of Medical Sciences, Sari, Iran.

Cystic fibrosis (CF) is associated with increased rates of morbidity and mortality due to fungal and bacterial colonization of the airways or respiratory infections. The prevalence of fungi in Iranian CF population has been underestimated. Therefore, the current study was conducted to define the frequency of fungi in respiratory specimens obtained from Iranian CF patients based on conventional and molecular assays. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1111/myc.12898DOI Listing
January 2019
7 Reads
1.805 Impact Factor

A pilot, layer-wise, ex vivo evaluation of the antifungal efficacy of amorolfine 5% nail lacquer versus other topical antifungal nail formulations in healthy toenails.

Mycoses 2019 Jan 22. Epub 2019 Jan 22.

Nestlé Skin Health - Galderma R&D, Switzerland.

Background: Studies investigating the penetration of amorolfine through the nail have shown the highest concentration in the uppermost layer and measurable antifungal activity even in the lower layers of the nail.

Objectives: This pilot, ex vivo study compared the penetration of antifungal concentrations of amorolfine 5% nail lacquer in different layers of healthy, human cadaver toenails with that of terbinafine 10% nail solution, ciclopirox 8% nail lacquer, and naftifine 1% nail solution. Moreover, the effect of nail filing prior to application on the penetration of amorolfine 5% was assessed. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1111/myc.12896DOI Listing
January 2019
5 Reads

In vitro susceptibility of dematiaceous fungi to nine antifungal agents determined by two different methods.

Mycoses 2019 Jan 21. Epub 2019 Jan 21.

Department of Medical Mycology, Institute of Dermatology, Chinese Academy of Medical Science and Peking Union Medical College, Nanjing, Jiangsu, 210042, People's Republic of China.

Background: The infection rate for dematiaceous fungi has increased rapidly over the most recent decades. However, the treatment for such infections has been lacking in empirical support with oral antifungal agents.

Objectives: To provide a better regimen for dematiaceous infections in future, the Sensititre YeastOne colorimetric antifungal panels were used and compared with Laboratory Standards Institute (CLSI) M38-A2 reference broth microdilution method. Read More

View Article

Download full-text PDF

Source
http://doi.wiley.com/10.1111/myc.12895
Publisher Site
http://dx.doi.org/10.1111/myc.12895DOI Listing
January 2019
4 Reads

Transcriptional profiling of macrophages infected with Fonsecaea monophora.

Mycoses 2019 Jan 17. Epub 2019 Jan 17.

Department of Dermatology and Venereology, Sun Yat-sen Memorial Hospital, Sun Yat-sen University.

Fonsecaea monophora is a member of dematiaceous fungi capable of causing Chromoblastomycosis through traumatic injury. However, little is known about the pathogenesis and early interactions between F. monophora and host. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1111/myc.12894DOI Listing
January 2019
2 Reads

Antifungal activity of selected Malassezia indolic compounds detected in culture.

Mycoses 2019 Jan 12. Epub 2019 Jan 12.

Mycology Research Laboratory and UOA/HCPF Culture Collection, Department of Microbiology, Medical School, National and Kapodistrian University of Athens.

Background: Malassezia yeasts produce bioactive indolic substances when grown on L-tryptophan agar. A panel of these substances was tested against commensal and opportunistic fungi, the Minimum Inhibitory Concentration (MIC) was determined and the potential for in loco antifungal activity on the skin was assessed.

Materials And Methods: Eight indoles were included (malassezin, pityriacitrin, indirubin, indolo[3,2b]carbazole, formyl-indolo[3,2 b]carbazole, tryptanthrin, 6-hydroxymethyl-indolo[3,2-b]carbazole and 6-methyl-indolo[3,2-b]carbazole) and were tested against 40 fungal strains [yeasts: Malassezia spp. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1111/myc.12893DOI Listing
January 2019
4 Reads

Antifungal susceptibility of yeast blood stream isolates collected during a 10 year period in Austria.

Mycoses 2019 Jan 12. Epub 2019 Jan 12.

Division of Clinical Microbiology, Department of Laboratory Medicine, Medical University of Vienna, Vienna, Austria.

Background: Candida-associated infections put a significant burden on western health care systems. Development of (multi-) resistant fungi can become untreatable and threaten especially vulnerable target groups, such as the immunocompromised.

Objectives: We assessed antifungal susceptibility and explored possible influence factors of clinical Candida isolates collected from Austrian hospitals between 2007 and 2016 METHODS: 1360 clinical Candida spp. Read More

View Article

Download full-text PDF

Source
http://doi.wiley.com/10.1111/myc.12892
Publisher Site
http://dx.doi.org/10.1111/myc.12892DOI Listing
January 2019
7 Reads

Validation of a multivariable prediction model for post-engraftment invasive fungal disease in 465 adult allogeneic hematopoietic stem cell transplant recipients.

Mycoses 2019 Jan 11. Epub 2019 Jan 11.

Department of Hematology, Hospital Universitari i Politècnic La Fe, València, Spain.

Background: Recently, we reported a simple prognostic score for post-engraftment invasive fungal disease (IFD) obtained in 404 adult allogeneic hematopoietic stem cell transplant (alloSCT) (training cohort).

Objectives: We aim to validate this score in an external cohort assessing the 1-year cumulative incidence (CI) of post-engraftment IFD. Additionally, we analyze the type of IFD, and incidence of IFD according to type of prophylaxis. Read More

View Article

Download full-text PDF

Source
http://doi.wiley.com/10.1111/myc.12891
Publisher Site
http://dx.doi.org/10.1111/myc.12891DOI Listing
January 2019
4 Reads

Clinical Mycology in Latin America and the Caribbean: a snapshot of diagnostic and therapeutic capabilities.

Mycoses 2019 Jan 7. Epub 2019 Jan 7.

Santa Casa de Misericordia de Porto Alegre, Porto Alegre, Brazil.

Despite the existence of endemic mycoses in Latin America and the Caribbean, in addition to a large population of patients at risk for invasive mycoses, the capability of medical centres to perform a proper diagnosis in mycology has not been studied in the region. Moreover, availability of antifungal drugs in the region is unknown. Here we report the results of a survey involving 129 centres in 24 countries. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1111/myc.12890DOI Listing
January 2019
1 Read

Oral clioquinol is effective in the treatment of a fly model of Candida systemic infection.

Mycoses 2019 Jan 1. Epub 2019 Jan 1.

Programa de Pós-Graduação em Microbiologia Agrícola e do Ambiente, Universidade Federal do Rio Grande do Sul, Porto Alegre, Brazil.

Background: Clioquinol was used in the 1950s-1970s as antimicrobial but its oral formulations were withdrawn from the market due to suspected neurotoxicity. Currently there is possibility of repositioning of oral clioquinol formulations.

Objectives: To evaluate the antifungal activity and toxicological parameters of clioquinol and the other two 8-hydroxyquinoline derivatives using alternative animal models and to study the interaction dynamic of clioquinol with Candida albicans. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1111/myc.12888DOI Listing
January 2019
1 Read

Molecular epidemiology and in vitro antifungal susceptibility of Trichophyton schoenleinii, agent of tinea capitis favosa.

Mycoses 2018 Dec 29. Epub 2018 Dec 29.

Westerdijk Fungal Biodiversity Institute, Utrecht, The Netherlands.

Trichophyton schoenleinii is an anthropophilic dermatophyte usually causing tinea favosa. Only few studies have provided data on molecular epidemiology and antifungal profiles of this fungus due to its limited prevalence after 1950s. Forty-nine strains from Asia (n=27), Africa (n=10), Europe (n=10) and from unknown regions (n=2) were analyzed with Amplified Fragment Length Polymorphism fingerprinting (AFLP) to reveal intraspecific genetic diversity in this dataset. Read More

View Article

Download full-text PDF

Source
http://doi.wiley.com/10.1111/myc.12889
Publisher Site
http://dx.doi.org/10.1111/myc.12889DOI Listing
December 2018
7 Reads

Clinical characteristics, rapid identification, molecular epidemiology and antifungal susceptibilities of Talaromyces marneffei infections in Shenzhen, China.

Mycoses 2018 Dec 29. Epub 2018 Dec 29.

Department of Microbiology, Li Ka Shing, Faculty of Medicine, The University of Hong Kong, Hong Kong.

Although case series of talaromycosis have been reported in China, their detailed clinical and microbiological characteristics have never been systematically profiled. In this study, we report the clinical characteristics, molecular epidemiology, rapid identification and antifungal susceptibilities of talaromycosis in The University of Hong Kong-Shenzhen Hospital in Shenzhen. Seven cases of talaromycosis were observed since commencement of hospital service in 2012. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1111/myc.12887DOI Listing
December 2018
1 Read

Candida auris otomycosis in Iran and review of recent literature.

Mycoses 2019 Feb;62(2):101-105

Department of Medical Mycology/Invasive Fungi Research Center (IFRC), School of Medicine, Mazandaran University of Medical Sciences, Sari, Iran.

Candida auris is a multidrug-resistant yeast emerging in immunocompromised and in otherwise healthy individuals. Due to difficulties in microbiological identification of C. auris because of the lack of available laboratory technology in developing countries, the number of patients affected is most likely underestimated. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1111/myc.12886DOI Listing
February 2019
1 Read
1.805 Impact Factor

Isavuconazole and voriconazole for the treatment of chronic pulmonary aspergillosis: A retrospective comparison of rates of adverse events.

Mycoses 2018 Dec 20. Epub 2018 Dec 20.

Division of Infection, Immunity and Respiratory Medicine, Faculty of Biology, Medicine and Health, University of Manchester, Manchester, UK.

Background: Long-term oral triazole antifungal therapy is the cornerstone of management for patients with chronic pulmonary aspergillosis (CPA). Itraconazole is the first-line choice of treatment. Voriconazole, posaconazole or isavuconazole can be used as alternative treatments in case of resistance or intolerance. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1111/myc.12885DOI Listing
December 2018
3 Reads
1.805 Impact Factor

Cryptococcal meningitis is a cause for cross-reactivity in cerebrospinal fluid assays for anti-Histoplasma, anti-Coccidioides and anti-Blastomyces antibodies.

Mycoses 2018 Dec 19. Epub 2018 Dec 19.

MiraVista Diagnostics, Indianapolis, Indianapolis, Indiana.

Background/objectives: Antibody detection is commonly used for diagnosis of histoplasmosis, and cross-reactions have been recognised due to endemic mycoses but not cryptococcosis. We observed cross-reactions in an anti-Histoplasma antibody enzyme immunoassay (EIA) in the cerebrospinal fluid (CSF) from a patient with cryptococcal meningitis and sought to assess the risk of cross-reactive anti-Histoplasma antibodies in persons with cryptococcal meningitis.

Methods: An anti-cryptococcal antibody EIA was developed to measure CSF antibody response in HIV-infected subjects from Kampala, Uganda and previously healthy, HIV-negative subjects at the National Institutes of Health (NIH) with cryptococcal meningitis. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1111/myc.12882DOI Listing
December 2018
4 Reads

Randomized clinical trial in women with Recurrent Vulvovaginal Candidiasis: efficacy of probiotics and lactoferrin as maintenance treatment.

Mycoses 2018 Dec 19. Epub 2018 Dec 19.

Department of Medical Science, University of Trieste, Trieste, Italy.

Background: Vulvovaginal candidiasis (VVC) is a recurrent vaginal condition in childbearing women.

Objectives: The aim of this study was to assess the efficacy of an oral formulation containing Lactobacillus acidophilus GLA-14, Lactobacillus rhamnosus HN001 and bovine lactoferrin on symptoms and recurrence of VVC as adjuvant therapy to topical clotrimazole.

Patients/methods: Forty-eight women positive for C. Read More

View Article

Download full-text PDF

Source
http://doi.wiley.com/10.1111/myc.12883
Publisher Site
http://dx.doi.org/10.1111/myc.12883DOI Listing
December 2018
6 Reads

Fungal infections of the central nervous system and paranasal sinuses in onco-haematologic patients. Epidemiological study reporting the diagnostic-therapeutic approach and outcome in 89 cases.

Mycoses 2018 Dec 19. Epub 2018 Dec 19.

Istituto di Ematologia, Polo Onco-Ematologico Fondazione Policlinico A. Gemelli-IRCCS, Università Cattolica del Sacro Cuore, Roma, Italy.

Invasive fungal infections (IFI) of the Central Nervous System (IFI-CNS) and Paranasal Sinuses (IFI-PS) are rare, life-threatening infections in haematologic patients, and their management remains a challenge despite the availability of new diagnostic techniques and novel antifungal agents. In addition, analyses of large cohorts of patients focusing on these rare IFI are still lacking. Between January 2010 and December 2016, 89 consecutive cases of Proven (53) or Probable (36) IFI-CNS (71/89) and IFI-PS (18/89) were collected in 34 haematological centres. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1111/myc.12884DOI Listing
December 2018
3 Reads

Point-of-care diagnosis of invasive aspergillosis in non-neutropenic patients: Aspergillus Galactomannan Lateral Flow Assay versus Aspergillus-specific Lateral Flow Device test in bronchoalveolar lavage.

Mycoses 2018 Dec 18. Epub 2018 Dec 18.

Department of Medicine, University of California San Diego, San Diego, California.

Background: We compared new Aspergillus Galactomannan Lateral Flow Assay with the newly formatted Aspergillus-specific Lateral Flow device tests for the diagnosis of invasive pulmonary aspergillosis (IPA) in non-neutropenic patients.

Methods: We performed both tests in 82 bronchoalveolar lavage fluid samples from 82 patients at risk for IPA but without underlying haematologic malignancy. Samples were collected between September 2016 and September 2018 at the University of California San Diego, United States. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1111/myc.12881DOI Listing
December 2018
3 Reads

Role of western blot assay for the diagnosis of histoplasmosis in AIDS patients from a National Institute of Infectious Diseases in Rio de Janeiro, Brazil.

Mycoses 2018 Dec 18. Epub 2018 Dec 18.

Instituto Nacional de Infectologia Evandro Chagas, Fundação Oswaldo Cruz, Rio de Janeiro, RJ, Brazil.

Background: Histoplasmosis is a frequent fungal infection in HIV/AIDS patients, with high morbimortality rates when diagnosis and treatment are delayed. Antibody detection, which is faster than the gold standard culture test, hastens the laboratory investigation.

Objectives: To evaluate the role of WB for antibody detection in the diagnosis of histoplasmosis among HIV/AIDS patients. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1111/myc.12877DOI Listing
December 2018
2 Reads

The current Indian epidemic of superficial dermatophytosis due to Trichophyton mentagrophytes - a molecular study.

Mycoses 2018 Dec 18. Epub 2018 Dec 18.

Laboratory for Medical Microbiology, Mölbis, Germany.

The disease burden of chronic relapsing and therapy refractory superficial dermatophytosis dramatically increased in India within the past 5-6 years. In order to evaluate the prevalence of this trend, 201 skin scrapings were collected from patients from all parts of India and were tested for dermatophytes using both, fungal culture and a PCR-ELISA directly performed with native skin scrapings. Fungal culture material was identified by genomic Sanger sequencing of the internal transcribed spacer (ITS) region and the translation elongation factor (TEF)-1α gene. Read More

View Article

Download full-text PDF

Source
http://doi.wiley.com/10.1111/myc.12878
Publisher Site
http://dx.doi.org/10.1111/myc.12878DOI Listing
December 2018
6 Reads

Microbiological characterisation of the colonisation by Candida sp in patients with orthodontic fixed appliances and evaluation of host responses in saliva.

Mycoses 2018 Dec 18. Epub 2018 Dec 18.

Programa de Microbiología y Micología, ICBM, Facultad de Medicina, Universidad de Chile, Santiago, Chile.

Objectives: We investigated the colonisation by Candida spp in patients using orthodontic fixed appliances by characterising the isolated Candida strains and by evaluating the host oral mucosa response through the measure of human β-defensins 3 (HBD-3) expression and Interleukin-1ß/IL-10.

Methods: Ninety patients were enrolled after signing an informed consent. Prevalence, susceptibility to fluconazole, genotyping and oral fungal burden of Candida sp. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1111/myc.12880DOI Listing
December 2018
1 Read

A randomised trial of vitamin D in acute-stage allergic bronchopulmonary aspergillosis complicating asthma.

Mycoses 2018 Dec 18. Epub 2018 Dec 18.

Department of Pulmonary Medicine, Postgraduate Institute of Medical Education and Research (PGIMER), Chandigarh, India.

Vitamin D has been demonstrated to have an immunomodulatory role in cystic fibrosis with allergic bronchopulmonary aspergillosis (ABPA). Herein, we evaluate supplemental vitamin D in acute-stage ABPA complicating asthma. Thirty subjects were randomised to receive either prednisolone (n = 15, control) or prednisolone and oral vitamin D (n = 15, intervention arm). Read More

View Article

Download full-text PDF

Source
http://doi.wiley.com/10.1111/myc.12879
Publisher Site
http://dx.doi.org/10.1111/myc.12879DOI Listing
December 2018
9 Reads
1.805 Impact Factor

Rhodotorula infection in haematological patient: Risk factors and outcome.

Mycoses 2018 Dec 7. Epub 2018 Dec 7.

Institute of Hematology, Fondazione Policlinico A. Gemelli - IRCCS-Università Cattolica del Sacro Cuore, Rome, Italy.

Background: Rhodotorula spp are uncommon yeasts able to cause infections with high mortality rates. Rhodotorula infections have been associated with the presence of central venous catheter (CVC), immunosuppression, exposure to antifungals and the presence of either solid or haematologic malignancies. However, in this latter setting, only a few cases have so far been reported. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1111/myc.12875DOI Listing
December 2018
14 Reads

The host range of dermatophytes, it is at all possible? Phenotypic evaluation of the keratinolytic activity of Trichophyton verrucosum clinical isolates.

Mycoses 2018 Dec 11. Epub 2018 Dec 11.

State Veterinary Laboratory, Lublin, Poland.

Dermatophytes are fungi that have an ability to invade keratinised structures. Enzymes secreted by dermatophytes can underlie fungal survival on the host and development of infection. It is possible that the range of activity of keratinases from various dermatophytes is limited to specific species of animals and groups of people. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1111/myc.12876DOI Listing
December 2018
2 Reads

Can intravenous antifungal therapy be safely used in the outpatient parenteral antimicrobial therapy (OPAT) setting?

Mycoses 2018 Nov 30. Epub 2018 Nov 30.

Department of Infectious Diseases, Mater Misericordiae University Hospital, Dublin, Ireland.

Outpatient parenteral antimicrobial therapy (OPAT) is an established treatment option for patients with a variety of infections who require a period of intravenous therapy, are clinically stable, and do not require continuous monitoring. Many patients with fungal infections require prolonged therapy due to resistance or intolerance to oral antifungal agents. Despite the widespread use of OPAT by infection specialists, antifungal agents appear infrequently used in this setting. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1111/myc.12874DOI Listing
November 2018
3 Reads

Outcome and potentially modifiable risk factors for candidemia in critically ill burns patients: A matched cohort study.

Mycoses 2018 Nov 27. Epub 2018 Nov 27.

Department of Anesthesiology and Critical Care and Burn Unit, AP-HP, Hôpital Saint-Louis, Paris, France.

Background: Patients with extensive burns are at risk of developing candidemia.

Objectives: To identify potentially modifiable risk factors and outcomes of candidemia in critically ill burns patients.

Patients And Methods: Retrospective matched cohort study including adult burns patients. Read More

View Article

Download full-text PDF

Source
http://doi.wiley.com/10.1111/myc.12872
Publisher Site
http://dx.doi.org/10.1111/myc.12872DOI Listing
November 2018
10 Reads

Managing liver dysfunction in haematology patients: Switch antifungals, or use the tincture of time?

Mycoses 2018 Nov 26. Epub 2018 Nov 26.

Michigan Medicine Department of Pharmacy, The University of Michigan College of Pharmacy, Ann Arbor, Michigan.

Liver function test (LFT) abnormalities are a common occurrence in haematology patients receiving antifungal therapies. The cause of elevated LFTs is often multifactorial. Posaconazole is associated with elevated LFTs in approximately 5%-10% of patients. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1111/myc.12871DOI Listing
November 2018
1 Read
1.805 Impact Factor

Evaluation of drug susceptibility test for Efinaconazole compared with conventional antifungal agents.

Mycoses 2018 Nov 14. Epub 2018 Nov 14.

Department of Dermatology, Konkuk University School of Medicine, Seoul, Korea.

Background: Superficial fungal infections are one of the most common and burdensome skin problems affecting quality of life in patients. Various conventional antifungal agents have been used to treat fungal infections; however, various problems have been reported including drug interaction, drug resistance and low effectiveness. Efinaconazole is a novel antifungal agent, which has proven to be particularly effective against onychomycosis compared with conventional antifungal agents. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1111/myc.12870DOI Listing
November 2018
2 Reads

Developing definitions for invasive fungal diseases in critically ill adult patients in intensive care units. Protocol of the FUNgal infections Definitions in ICU patients (FUNDICU) project.

Mycoses 2018 Nov 13. Epub 2018 Nov 13.

Infectious Diseases Service, Department of Medicine, Lausanne University, Lausanne, Switzerland.

Background: The reliability of diagnostic criteria for invasive fungal diseases (IFD) developed for severely immunocompromised patients is questionable in critically ill adult patients in intensive care units (ICU).

Objectives: To develop a standard set of definitions for IFD in critically ill adult patients in ICU.

Methods: Based on a systematic literature review, a list of potential definitions to be applied to ICU patients will be developed by the ESCMID Study Group for Infections in Critically Ill Patients (ESGCIP) and the ESCMID Fungal Infection Study Group (EFISG) chairpersons. Read More

View Article

Download full-text PDF

Source
http://doi.wiley.com/10.1111/myc.12869
Publisher Site
http://dx.doi.org/10.1111/myc.12869DOI Listing
November 2018
8 Reads

First-time isolation and quantification of Basidiobolus spp. from reptile faeces in KwaZulu-Natal (South Africa) using selective media.

Mycoses 2018 Nov 8. Epub 2018 Nov 8.

Discipline of Microbiology, School of Life Sciences, University of KwaZulu-Natal, Pietermaritzburg, South Africa.

Members of the genus Basidiobolus are potentially pathogenic fungi, known to cause mycoses in tropical and subtropical countries. Basidiobolus spp. can be associated with animals, and reptiles and amphibians are candidate vectors for the distribution of this fungus. Read More

View Article

Download full-text PDF

Source
http://doi.wiley.com/10.1111/myc.12868
Publisher Site
http://dx.doi.org/10.1111/myc.12868DOI Listing
November 2018
4 Reads

False positive bronchoalveolar lavage galactomannan: Effect of host and cut-off value.

Mycoses 2018 Nov 1. Epub 2018 Nov 1.

Brigham and Women's Hospital, Rhode Island Hospital, Division of Infectious Diseases, Harvard Medical School, Boston, Massachusetts.

Objectives: Bronchoalveolar lavage galactomannan (BAL-GM) is a mycological criterion for diagnosis of probable invasive aspergillosis (IA) per European Organization for Research and Treatment of Cancer/Mycoses Study Group (EORT-MSG) consensus criteria, but its real-world positive predictive value (PPV) has not been well-studied. Our aim was to estimate the PPV of BAL-GM in a contemporary cohort of patients with positive BAL-GM.

Methods: We identified consecutive patients with ≥1 positive BAL-GM value (index ≥ 0. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1111/myc.12867DOI Listing
November 2018
3 Reads

Perspectives on misidentification of Trichophyton interdigitale/Trichophyton mentagrophytes using internal transcribed spacer region sequencing: Urgent need to update the sequence database.

Mycoses 2019 Jan 15;62(1):11-15. Epub 2018 Nov 15.

Department of Medical Microbiology and Infectious Diseases, Canisius-Wilhelmina Hospital, Nijmegen, The Netherlands.

The taxonomy of the dermatophytes has been revisited using a novel multilocus phylogenetic approach, and several neotypes and reference strains have been assigned for Trichophyton species. Single gene sequencing, that is the ITS region, for identification of highly related species T. mentagrophytes/T. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1111/myc.12865DOI Listing
January 2019
5 Reads
1.805 Impact Factor

DC-SIGN and VDR polymorphisms are associated with chronic form of paracoccidioidomycosis with oral manifestations.

Mycoses 2019 Feb 19;62(2):186-192. Epub 2018 Nov 19.

Departamento de Microbiologia e Imunologia, Universidade Federal de Alfenas, Alfenas, MG, Brazil.

Paracoccidioidomycosis (PCM) is a granulomatous disease caused by fungi of the species complex of the Paracoccidioides genus. One of the main clinical manifestations of PCM is the presence of oral lesions with the presence of epithelioid granulomas. In this work, we aimed to evaluate the frequency of SNPs in the TNF-α, JAK1, VDR, DC-SIGN and FcγRIIa genes in patients with chronic PCM and verify possible association of these SNPs with the organisation pattern of the granulomas in the oral lesions. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1111/myc.12866DOI Listing
February 2019
3 Reads

Exserohilum infections in Australian Queensland children.

Mycoses 2019 Feb 6;62(2):181-185. Epub 2018 Nov 6.

Infection Management and Prevention Service, Queensland Children's Hospital, Brisbane, Queensland, Australia.

Background: Exserohilum species are environmental moulds that can cause skin infection and sinusitis in both normal and immunosuppressed children. This study reviews paediatric cases of Exserohilum infection in Queensland, Australia, to identify the spectrum of disease and its clinical course.

Methods: All culture-positive samples of Exserohilum species in children <18 years of age were identified from the Queensland Health Laboratory database (April 2003-April 2018). Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1111/myc.12864DOI Listing
February 2019
13 Reads

Genotypic diversity and antifungal susceptibility of Cryptococcus neoformans isolates from paediatric patients in China.

Mycoses 2019 Feb 13;62(2):171-180. Epub 2018 Nov 13.

Department of Dermatology, Changzheng Hospital, Second Military Medical University, Shanghai, China.

Cryptococcosis is a life-threatening mycosis primarily occurring in adult patients particularly those with immunosuppression such as HIV infection/AIDS. The number of reported cases of paediatric cryptococcosis has increased in the last decade around the world, including China. However, current information on the characteristics of cryptococcosis in children, particularly the genotypic diversity and antifungal susceptibility of the isolates, is limited. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1111/myc.12863DOI Listing
February 2019
4 Reads
1.805 Impact Factor

Invasive mucormycosis in children with cancer: A retrospective study from the Infection Working Group of Italian Pediatric Hematology Oncology Association.

Mycoses 2019 Feb 13;62(2):165-170. Epub 2018 Nov 13.

Pediatric Hematology Oncology, Azienda Ospedaliera Universitaria Integrata, Verona, Italy.

Background: Invasive mucormycosis is a rare but frequently fatal fungal disease. The acute and rapidly progressive evolution causes unfavourable outcome in 22%-59% of patients and its treatment represents a clinical challenge, especially in immunocompromised patients. Current data in paediatric oncological patients are limited. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1111/myc.12862DOI Listing
February 2019
4 Reads
1.805 Impact Factor

A human subcutaneous infection by Microascus ennothomasiorum sp. nov.

Mycoses 2019 Feb 13;62(2):157-164. Epub 2018 Nov 13.

Unitat de Micologia, Facultat de Medicina i Ciències de la Salut and IISPV, Universitat Rovira i Virgili, Reus, Spain.

A 60-year-old woman presented with a nodular granulomatous skin lesion on her right thumb. It had developed after inoculation of a splinter of wood. Because it was resistant to various therapies, the nodule was finally excised. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1111/myc.12861DOI Listing
February 2019
1 Read

Diagnostic workout to assess early response indicators in invasive pulmonary aspergillosis in adult patients with hematologic malignancies.

Mycoses 2018 Oct 17. Epub 2018 Oct 17.

Department of Internal Medicine-Hematology and Oncology, Mannheim University Hospital, Heidelberg University, Theodor-Kutzer-Ufer 1-3, D-68167, Mannheim, Germany.

In immunocompromised patients with acute leukaemia as well as in allogeneic hematopoietic stem cell transplant patients, pulmonary lesions are commonly seen. Existing guidelines provide useful algorithms for diagnostic procedures and treatment options, but they do not give recommendations on how to evaluate early success or failure and if or when it is best to change therapy. Here we review the diagnostic techniques currently used in association with clinical findings and propose an approach using a combination of computer tomography, clinical and all available biomarkers and inflammation parameters, especially those positive at baseline, to assess early response in invasive pulmonary aspergillosis. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1111/myc.12860DOI Listing
October 2018
8 Reads

Prevalence of low inflammatory tinea genitalis in southern China.

Mycoses 2018 Oct 11. Epub 2018 Oct 11.

Department of Dermatology, Third Affiliated Hospital, Sun Yat-sen University, Guangzhou, China.

Background: Emergence of highly inflammatory genital dermatophyte infections has been reported from Southeast Asia. In view of this, knowledge of the non-outbreak fungal flora of the genitals is required as a baseline study.

Objectives: We present our 12-year experience in a tertiary clinic with the diagnosis of scrotal fungal infections. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1111/myc.12859DOI Listing
October 2018
3 Reads

Rhodotorula species infections in humans: A systematic review.

Mycoses 2019 Feb 17;62(2):90-100. Epub 2018 Oct 17.

Department of Internal Medicine & Infectious Diseases, University Hospital of Heraklion, Heraklion, Greece.

Background: Fungal infections by Rhodotorula species are increasingly reported in the literature and consist of bloodstream infections, especially in patients with central venous catheters (CVC), as well as central nervous system (CNS), ocular and other less frequent infections.

Objectives: The aim of this systematic review was to record and evaluate all available evidence regarding infections by Rhodotorula species.

Methods: Systematic review of PubMed (through 9 August 2017) for studies providing epidemiological, clinical, microbiological, as well as treatment data and outcomes of Rhodotorula species infections. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1111/myc.12856DOI Listing
February 2019
3 Reads

Micafungin may be safely administered as outpatient parenteral antimicrobial therapy for chronic pulmonary aspergillosis.

Mycoses 2019 Feb 19;62(2):152-156. Epub 2018 Oct 19.

ECMM Centre of Excellence in Clinical and Laboratory Mycology and Clinical Studies, The National Aspergillosis Centre, Wythenshawe Hospital, Manchester University NHS Foundation Trust, Manchester, UK.

Background: Intravenous micafungin has been reported as a treatment alternative in patients with chronic pulmonary aspergillosis (CPA) where long-term oral triazole therapy is unfeasible.

Objectives: We evaluated the safety and efficacy of micafungin administered via the outpatient parenteral antimicrobial therapy (OPAT) service for the treatment of CPA.

Methods: We included all CPA patients who received micafungin via OPAT between April 2016 and March 2018. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1111/myc.12857DOI Listing
February 2019
3 Reads
1.805 Impact Factor

Epidemiology of Aspergillus species causing keratitis in Mexico.

Mycoses 2019 Feb 14;62(2):144-151. Epub 2018 Oct 14.

Laboratory of Microbiology, Asociacion para Evitar la Ceguera en Mexico Hospital "Dr. Luis Sanchez-Bulnes", Coyoacán, Mexico.

Background: The incidence of fungal keratitis has increased in recent years. While the epidemiology and clinical roles of various Candida and Fusarium species have been relatively well-identified in infections of the eye, data regarding keratitis caused by Aspergillus species are scant. Accurate and rapid diagnosis is important for successful management of this infection. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1111/myc.12855DOI Listing
February 2019
2 Reads

Molecular identification and antifungal susceptibility of clinical fungal isolates from onychomycosis (uncommon and emerging species).

Mycoses 2019 Feb 13;62(2):128-143. Epub 2018 Nov 13.

Department of Medical Mycology, Invasive Fungi Research Center, School of Medicine, Mazandaran University of Medical Sciences, Sari, Iran.

Onychomycosis is a common nail problem, accounting for up to 50% of all nail diseases. The aim of the present study was to determine the species distribution based on the restriction fragment length polymorphism and susceptibility patterns of the causative agents of onychomycosis. This cross-sectional study was conducted on nail samples collected from 257 patients suspected of onychomycosis during 14 months. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1111/myc.12854DOI Listing
February 2019
11 Reads
1.805 Impact Factor

The epidemiology of non-Candida yeast isolated from blood: The Asia Surveillance Study.

Mycoses 2019 Feb 17;62(2):112-120. Epub 2018 Oct 17.

Division of Infectious Diseases, Department of Internal Medicine, National Taiwan University Hospital and College of Medicine, Taipei, Taiwan.

Background: Current guidelines recommend echinocandins as first-line therapy for candidemia. However, several non-Candida yeast are non-susceptible to echinocandins (echinocandin non-susceptible yeast, ENSY), including Cryptococcus, Geotrichum, Malassezia, Pseudozyma, Rhodotorula, Saprochaete, Sporobolomyces and Trichosporon. In laboratories that are not equipped with rapid diagnostic tools, it often takes several days to identify yeast, and this may lead to inappropriate presumptive use of echinocandins in patients with ENSY fungemia. Read More

View Article

Download full-text PDF

Source
http://doi.wiley.com/10.1111/myc.12852
Publisher Site
http://dx.doi.org/10.1111/myc.12852DOI Listing
February 2019
14 Reads

Cutaneous infections by dematiaceous opportunistic fungi: Diagnosis and management in 11 solid organ transplant recipients.

Mycoses 2019 Feb 17;62(2):121-127. Epub 2018 Oct 17.

Department of Dermatology, Hospital Universitari Vall d'Hebron, Barcelona, Spain.

Background: The incidence of cutaneous infections by dematiaceous fungi is rising in our environment due to the high number of solid organ transplant recipients (SOTR).

Objective: To review our experience in the management of cutaneous phaeohyphomycoses in a Spanish reference centre for dermatological care of SOTR.

Methods: Retrospective clinical, histopathological and microbiological review of all SOTR diagnosed of a phaeohyphomycosis in a 7-year period. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1111/myc.12853DOI Listing
February 2019
1 Read