3,589 results match your criteria Mycoses[Journal]


Overview And Outcome Of Mucormycosis Among Children With Cancer; Report From The Children's Cancer Hospital Egypt.

Mycoses 2019 Apr 14. Epub 2019 Apr 14.

Pediatric Oncology department, National cancer institute - Cairo University, Children Cancer Hospital, 57357.

Mucormycosis represents a real challenge in immunocompromised patients. This study aimed to describe the clinical characteristics, treatment outcome and infection-related mortality in our patients at the children's cancer hospital 57357, Cairo, Egypt.This is a retrospective study during the period 2007-2017. Read More

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http://dx.doi.org/10.1111/myc.12915DOI Listing
April 2019
1 Read

Tinea Capitis in Adults; A 18-year Retrospective, Single Centre Study in Korea.

Mycoses 2019 Apr 13. Epub 2019 Apr 13.

Department of Dermatology, Chonbuk National University Medical School, Jeonju, Korea.

Background: Tinea capitis (TC) is a dermatophyte infection involving hair and scalp and occurs primarily in prepubertal children. However, data on adults are limited.

Objectives: The aim of this study is to evaluate epidemiological, clinical, and mycological characteristics of TC in adults in Korea. Read More

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https://onlinelibrary.wiley.com/doi/abs/10.1111/myc.12916
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http://dx.doi.org/10.1111/myc.12916DOI Listing
April 2019
3 Reads

Tinea manuum: a report of 18 cases observed in the metropolitan area of Milan and review of the literature.

Mycoses 2019 Mar 31. Epub 2019 Mar 31.

Department of Pathophysiology and Transplantation, Università degli Studi di Milano, Foundation IRCCS, Cà Granda Ospedale Maggiore Policlinico, Milan, Italy.

Objective: Tinea manuum is considered in Italy as an uncommon infection, although no recent epidemiological data are available.

Methods: In the period 2000-2018, we observed in the metropolitan area of Milan 18 patients with mycologically tinea manuum.

Results: The infection was monolateral in all patients and characterized by erythema and scaling; in two patients each vesicles and pustules were present. Read More

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http://dx.doi.org/10.1111/myc.12914DOI Listing
March 2019
2 Reads

Contribution of Malassezia spp. to the development of atopic dermatitis.

Mycoses 2019 Mar 25. Epub 2019 Mar 25.

Department of Pharmaceutical Microbiology and Parasitology, Wroclaw Medical University, Wrocław, Poland.

The prevalence of atopic dermatitis (AD) has been increasing. Whereas AD symptoms are obvious and easy to recognize, the etiopathogenesis remains not fully elucidated. Recently, the role of microorganisms and their impact on the immunology of AD has been discussed. Read More

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https://onlinelibrary.wiley.com/doi/abs/10.1111/myc.12913
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http://dx.doi.org/10.1111/myc.12913DOI Listing
March 2019
3 Reads

Systemic antifungal drug use in Belgium-One of the biggest antifungal consumers in Europe.

Mycoses 2019 Mar 19. Epub 2019 Mar 19.

Healthcare-Associated Infections and Antimicrobial Resistance, Sciensano, Brussels, Belgium.

Background: Reports on the consumption of systemic antifungal drugs on a national level are scarce although of high interest to compare trends and the associated epidemiology in other countries and to assess the need for antifungal stewardship programmes.

Objectives: To estimate patterns of Belgian inpatient and outpatient antifungal use and provide reference data for other countries.

Methods: Consumption records of antifungals were collected in Belgian hospitals between 2003 and 2016. Read More

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http://dx.doi.org/10.1111/myc.12912DOI Listing
March 2019
1 Read

Posaconazole salvage therapy: The Posifi study.

Mycoses 2019 Mar 12. Epub 2019 Mar 12.

Infectious Diseases Department, Hospital Ramón y Cajal, IRYCIS (Instituto Ramón y Cajal de Investigación Sanitaria), Universidad de Alcalá, Madrid, Spain.

Background: Posaconazole (PCZ) is used mainly for the prevention of invasive fungal infection (IFI).

Methods: A multicentre retrospective, investigational study using a non-randomized, single-arm design carried out in six tertiary hospitals in Spain to evaluate the use of PCZ in different forms of administration in the (non-prophylactic) treatment of IFI.

Results: Over an eight-year-period, 67 patients were included in this study. Read More

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http://dx.doi.org/10.1111/myc.12911DOI Listing
March 2019
10 Reads

Real-world use-Isavuconazole at a large academic medical center.

Mycoses 2019 Mar 9. Epub 2019 Mar 9.

Department of Infectious Disease, Cleveland Clinic, Cleveland, Ohio.

Background: Isavuconazole use in the real-world setting has not been extensively described. Subgroups of patients with particular prognostic significance, such as previous triazole prophylaxis or treatment and the important subgroup treated empirically for invasive fungal infection, have beforehand been excluded from trials.

Objectives: We aimed to determine treatment response and safety in these patients at a large US transplant and cancer centre. Read More

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http://dx.doi.org/10.1111/myc.12910DOI Listing

Antifungal combinations in Mucorales: a microbiological perspective.

Mycoses 2019 Mar 4. Epub 2019 Mar 4.

Université Paris Descartes, Faculté de Médecine, AP-HP, Hôpital Européen Georges Pompidou, Unité de Parasitologie-Mycologie, F-75015, Paris, France.

Mucormycosis mostly affects immunocompromised patients and is associated with a high morbidity and mortality despite currently available treatments. In that context, combination therapy might be the key to a better outcome for these patients. Purpose of this review is to summarize and discuss the current combination data obtained in vitro, in vivo in animal models of mucormycosis, and in patients. Read More

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http://dx.doi.org/10.1111/myc.12909DOI Listing
March 2019
2 Reads

Comparison of genotyping methods for Cunninghamella bertholletiae.

Mycoses 2019 Mar 2. Epub 2019 Mar 2.

Institute of Medical Microbiology, University Hospital Essen, University of Duisburg-Essen, Essen, Germany.

Background: Invasive fungal infections caused by filamentous fungi of the order Mucorales are serious complications in immunocompromised patients and often associated with fatal outcome. As a member of this order, Cunninghamella bertholletiae is a saprophytic fungus with naturally exhibited high minimum inhibitory concentrations against common antifungal drugs and with the potential for outbreaks in clinical settings.

Objectives And Methods: In a proof-of-principle study, we evaluated the performance of microsatellite markers for the discrimination of thirteen C. Read More

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http://dx.doi.org/10.1111/myc.12908DOI Listing

A high-throughput and rapid method for accurate identification of emerging multidrug-resistant Candida auris.

Mycoses 2019 Feb 23. Epub 2019 Feb 23.

Enhanced Capacity Surge Laboratory, Reagent and Diagnostic Services Branch, Division of Scientific Resources, National Center for Emerging and Zoonotic Infectious Diseases (NCEZID) Centers for Disease Control & Prevention (CDC), Atlanta, Georgia.

Candida auris is an emerging multidrug-resistant yeast associated with invasive infection in healthcare settings. Recently, C auris cases in the United States have been detected in 11 states with the majority of cases in New York, New Jersey and Illinois. Rapid and accurate identification of C auris is critical for patient care and the implementation of public health measures to control the spread of infection. Read More

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http://dx.doi.org/10.1111/myc.12907DOI Listing
February 2019
2 Reads

In vitro activity of diphenyl diselenide and ebselen alone and in combination with antifungal agents against Trichosporon asahii.

Mycoses 2019 May 13;62(5):428-433. Epub 2019 Mar 13.

Department of Microbiology and Parasitology, Federal University of Santa Maria (UFSM), Santa Maria, Brazil.

This study evaluated the in vitro susceptibility of Trichosporon asahii strains to diphenyl diselenide (DPDS) and ebselen (EBS) alone and in combination with amphotericin B (AMB), fluconazole (FCZ), itraconazole (ITZ) and caspofungin (CAS) using the microdilution method. EBS showed in vitro activity against T asahii strains with minimal inhibitory concentration (MIC) ranged from 0.25 to 8. Read More

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http://dx.doi.org/10.1111/myc.12906DOI Listing

In vitro combination between antifungals and diphenyl diselenide against Cryptococcus species.

Mycoses 2019 Feb 18. Epub 2019 Feb 18.

Postgraduate Program in Pharmaceutical Sciences, Health Sciences Centre, Federal University of Santa Maria (UFSM), Santa Maria, Rio Grande do Sul, Brazil.

Cryptococcus species are an encapsulated fungal pathogen that cause cryptococcal meningitis. There are limited therapeutic options for this infection. The management includes the use of different antifungals such as amphotericin B, flucytosine, or fluconazole, either alone or in combination. Read More

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http://dx.doi.org/10.1111/myc.12905DOI Listing
February 2019
1 Read
1.805 Impact Factor

Candida auris - the growing menace to global health.

Mycoses 2019 Feb 17. Epub 2019 Feb 17.

Clinical Microbiology and Infectious Diseases, School of Pathology, Faculty of Health Sciences, University of the Witwatersrand, Johannesburg, 2193, South Africa.

A paradigm shift of candidiasis from Candida albicans to non-albicans Candida species has fundamentally increased with the advent of C. auris. C. Read More

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http://dx.doi.org/10.1111/myc.12904DOI Listing
February 2019

Killing of Candida auris by UV-C: Importance of exposure time and distance.

Mycoses 2019 May 12;62(5):408-412. Epub 2019 Mar 12.

Department of Medical Microbiology and Infectious Diseases, Canisius Wilhelmina Hospital (CWZ), Nijmegen, The Netherlands.

Background: Candida auris is a globally emerging yeast, causing severe infections in patients with underlying diseases. This yeast is responsible for several outbreaks within healthcare facilities, where it can be found on hospital surfaces and patient care devices. Spread from these fomites may be prevented by improving the decontamination of hospital surfaces. Read More

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http://doi.wiley.com/10.1111/myc.12903
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http://dx.doi.org/10.1111/myc.12903DOI Listing
May 2019
5 Reads

Can urinary histoplasma antigen test improve the diagnosis of histoplasmosis in a tuberculosis endemic region?

Mycoses 2019 Feb 8. Epub 2019 Feb 8.

Microbiology Post Graduate Institute of Medical Education and Research, Chandigarh, India.

Background: Many patients with histoplasmosis are treated with anti-tubercular therapy (ATT) in tuberculosis endemic regions as diagnosis of histoplasmosis requires invasive sampling. We sought to study the utility of urinary Histoplasma antigen detection test.

Methods: Case records of patients with a diagnosis of histoplasmosis prior to (Period A) and after (Period B) introduction of urinary Histoplasma antigen detection test were analysed in this single centre retrospective study. Read More

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http://doi.wiley.com/10.1111/myc.12902
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http://dx.doi.org/10.1111/myc.12902DOI Listing
February 2019
16 Reads

Outcomes of patients with invasive fusariosis who undergo further immunosuppressive treatments, is there a role for secondary prophylaxis?

Mycoses 2019 May;62(5):413-417

Division of Infectious Diseases, Harvard Medical School, Brigham and Women's Hospital, Boston, Massachusetts.

Background: Patients treated for invasive aspergillosis may relapse during subsequent periods of immunosuppression and should receive secondary prophylaxis. Little is known about the frequency of relapse and practices of secondary prophylaxis for invasive fusariosis (IF).

Objectives: Evaluate practices of secondary prophylaxis and the frequency of relapse in patients who survived IF and were exposed to subsequent periods of immunosuppression. Read More

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http://dx.doi.org/10.1111/myc.12901DOI Listing
May 2019
7 Reads

Species distribution and epidemiological characteristics of superficial fungal infections in Southeastern Serbia.

Mycoses 2019 May 14;62(5):458-465. Epub 2019 Mar 14.

Department of Microbiology and Immunology, Faculty of Medicine, University of Belgrade, Belgrade, Serbia.

Background: Superficial fungal infections (SFI), one of the most prevalent diseases in the world, are infections of keratin-rich structures of human body mostly caused by dermatophytes and yeasts.

Objectives: The goal of this study was to determine the possible changes in the epidemiology of SFI on the territory of Southeastern Serbia and to investigate epidemiological characteristics and the influence of SFI on the patient's quality of life.

Methods: From 2012 to the end of 2017, samples of 1643 patients (568 males and 1075 females, mean age 40. Read More

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http://dx.doi.org/10.1111/myc.12900DOI Listing

A pharmacokinetic model for voriconazole in a highly diversified population of children and adolescents with cancer.

Mycoses 2019 Apr 20;62(4):399-404. Epub 2019 Feb 20.

Pediatric Oncology Department, GRAACC/IOP/UNIFESP, and Pediatric Department, UNIFESP, Grupo de Apoio ao Adolescente e à Criança com Câncer (GRAACC), Instituto de Oncologia Pediátrica (IOP), Sao Paulo Federal University (UNIFESP), São Paulo, Brazil.

Background: The wide pharmacokinetic variability of voriconazole leads to uncertainty regarding adequate exposure.

Objectives: To create a pharmacokinetic model that could help to explain the variability.

Methods: Retrospective review of paediatric patients with cancer. Read More

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http://dx.doi.org/10.1111/myc.12899DOI Listing
April 2019
2 Reads

Mucormycosis-A clinicoepidemiological review of cases over 10 years.

Mycoses 2019 Apr 19;62(4):391-398. Epub 2019 Feb 19.

Christian Medical College, Vellore, Tamil Nadu, India.

Background: Limited data exist for epidemiology and outcomes of various agents causing mucormycosis in various clinical settings from developing countries like India.

Objectives: To study the epidemiology and outcomes of various agents causing mucormycosis in different clinical settings in a tertiary care hospital from South India.

Patients And Methods: We reviewed details of 184 consecutive patients with culture-proven mucormycosis with consistent clinical syndrome and supporting features from September 2005 to September 2015. Read More

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http://dx.doi.org/10.1111/myc.12897DOI Listing
April 2019
5 Reads

Airway colonisation by Candida and Aspergillus species in Iranian cystic fibrosis patients.

Mycoses 2019 May 13;62(5):434-440. Epub 2019 Mar 13.

Department of Medical Mycology, School of Medicine, Mazandaran University of Medical Sciences, Sari, Iran.

Cystic fibrosis (CF) is associated with increased rates of morbidity and mortality due to fungal and bacterial colonisation of the airways or respiratory infections. The prevalence of fungi in Iranian CF population has been underestimated. Therefore, the current study was conducted to define the frequency of fungi in respiratory specimens obtained from Iranian CF patients based on conventional and molecular assays. Read More

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http://dx.doi.org/10.1111/myc.12898DOI Listing
May 2019
10 Reads
1.805 Impact Factor

A pilot, layerwise, ex vivo evaluation of the antifungal efficacy of amorolfine 5% nail lacquer vs other topical antifungal nail formulations in healthy toenails.

Mycoses 2019 Jan 22. Epub 2019 Jan 22.

Nestlé Skin Health-Galderma R&D, Lausanne, Switzerland.

Background: Studies investigating the penetration of amorolfine through the nail have shown the highest concentration in the uppermost layer and measurable antifungal activity even in the lower layers of the nail.

Objectives: This pilot, ex vivo study compared the penetration of antifungal concentrations of amorolfine 5% nail lacquer in different layers of healthy, human cadaver toenails with that of terbinafine 10% nail solution, ciclopirox 8% nail lacquer and naftifine 1% nail solution. Moreover, the effect of nail filing prior to application on the penetration of amorolfine 5% was assessed. Read More

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http://dx.doi.org/10.1111/myc.12896DOI Listing
January 2019
16 Reads

In vitro susceptibility of dematiaceous fungi to nine antifungal agents determined by two different methods.

Mycoses 2019 Apr 20;62(4):384-390. Epub 2019 Feb 20.

Department of Medical Mycology, Institute of Dermatology, Chinese Academy of Medical Science and Peking Union Medical College, Nanjing, Jiangsu, China.

Background: The infection rate for dematiaceous fungi has increased rapidly over the most recent decades. However, the treatment for such infections has been lacking in empirical support with oral antifungal agents.

Objectives: To provide a better regimen for dematiaceous infections in future, the Sensititre YeastOne® colorimetric antifungal panels were used and compared with Laboratory Standards Institute (CLSI) M38-A2 reference broth microdilution method. Read More

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http://doi.wiley.com/10.1111/myc.12895
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http://dx.doi.org/10.1111/myc.12895DOI Listing
April 2019
10 Reads

Transcriptional profiling of macrophages infected with Fonsecaea monophora.

Mycoses 2019 Apr 20;62(4):374-383. Epub 2019 Feb 20.

Department of Dermatology and Venereology, Sun Yat-sen Memorial Hospital, Sun Yat-sen University, Guangzhou, China.

Fonsecaea monophora is a member of dematiaceous fungi capable of causing chromoblastomycosis through traumatic injury. However, little is known about the pathogenesis and early interactions between F. monophora and host. Read More

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http://dx.doi.org/10.1111/myc.12894DOI Listing
April 2019
3 Reads

Antifungal activity of selected Malassezia indolic compounds detected in culture.

Mycoses 2019 Jan 12. Epub 2019 Jan 12.

Mycology Research Laboratory and UOA/HCPF Culture Collection, Department of Microbiology, Medical School, National and Kapodistrian University of Athens.

Background: Malassezia yeasts produce bioactive indolic substances when grown on L-tryptophan agar. A panel of these substances was tested against commensal and opportunistic fungi, the Minimum Inhibitory Concentration (MIC) was determined and the potential for in loco antifungal activity on the skin was assessed.

Materials And Methods: Eight indoles were included (malassezin, pityriacitrin, indirubin, indolo[3,2b]carbazole, formyl-indolo[3,2 b]carbazole, tryptanthrin, 6-hydroxymethyl-indolo[3,2-b]carbazole and 6-methyl-indolo[3,2-b]carbazole) and were tested against 40 fungal strains [yeasts: Malassezia spp. Read More

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http://dx.doi.org/10.1111/myc.12893DOI Listing
January 2019
5 Reads

Antifungal susceptibility of yeast bloodstream isolates collected during a 10-year period in Austria.

Mycoses 2019 Apr 20;62(4):357-367. Epub 2019 Feb 20.

Division of Clinical Microbiology, Department of Laboratory Medicine, Medical University of Vienna, Vienna, Austria.

Background: Candida-associated infections put a significant burden on western healthcare systems. Development of (multi-)resistant fungi can become untreatable and threaten especially vulnerable target groups, such as the immunocompromised.

Objectives: We assessed antifungal susceptibility and explored possible influence factors of clinical Candida isolates collected from Austrian hospitals between 2007 and 2016. Read More

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http://doi.wiley.com/10.1111/myc.12892
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http://dx.doi.org/10.1111/myc.12892DOI Listing
April 2019
17 Reads

Validation of a multivariable prediction model for post-engraftment invasive fungal disease in 465 adult allogeneic hematopoietic stem cell transplant recipients.

Mycoses 2019 May 8;62(5):418-427. Epub 2019 Mar 8.

Department of Hematology, Hospital Universitari i Politècnic La Fe, València, Spain.

Background: Recently, we reported a simple prognostic score for post-engraftment invasive fungal disease (IFD) obtained in 404 adult allogeneic hematopoietic stem cell transplant (alloSCT) (training cohort).

Objectives: We aim to validate this score in an external cohort assessing the 1-year cumulative incidence (CI) of post-engraftment IFD. Additionally, we analyse the type of IFD and incidence of IFD according to type of prophylaxis. Read More

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http://doi.wiley.com/10.1111/myc.12891
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http://dx.doi.org/10.1111/myc.12891DOI Listing
May 2019
9 Reads

Clinical mycology in Latin America and the Caribbean: A snapshot of diagnostic and therapeutic capabilities.

Mycoses 2019 Apr 20;62(4):368-373. Epub 2019 Feb 20.

Santa Casa de Misericordia de Porto Alegre, Porto Alegre, Brazil.

Despite the existence of endemic mycoses in Latin America and the Caribbean, in addition to a large population of patients at risk for invasive mycoses, the capability of medical centres to perform a proper diagnosis in mycology has not been studied in the region. Moreover, availability of antifungal drugs in the region is unknown. Here, we report the results of a survey involving 129 centres in 24 countries. Read More

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http://dx.doi.org/10.1111/myc.12890DOI Listing
April 2019
3 Reads

Oral clioquinol is effective in the treatment of a fly model of Candida systemic infection.

Mycoses 2019 May 26;62(5):475-481. Epub 2019 Mar 26.

Programa de Pós-Graduação em Microbiologia Agrícola e do Ambiente, Universidade Federal do Rio Grande do Sul, Porto Alegre, Brazil.

Background: Clioquinol was used in the 1950s-1970s as antimicrobial but its oral formulations were withdrawn from the market due to suspected neurotoxicity. Currently, there is possibility of repositioning of oral clioquinol formulations.

Objectives: To evaluate the antifungal activity and toxicological parameters of clioquinol and the other two 8-hydroxyquinoline derivatives using alternative animal models and to study the interaction dynamic of clioquinol with Candida albicans. Read More

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http://dx.doi.org/10.1111/myc.12888DOI Listing
May 2019
2 Reads

Molecular epidemiology and in vitro antifungal susceptibility of Trichophyton schoenleinii, agent of tinea capitis favosa.

Mycoses 2019 May;62(5):466-474

Westerdijk Fungal Biodiversity Institute, Utrecht, The Netherlands.

Trichophyton schoenleinii is an anthropophilic dermatophyte usually causing tinea favosa. Only few studies have provided data on molecular epidemiology and antifungal profiles of this fungus due to its limited prevalence after 1950s. Forty-nine strains from Asia (n = 27), Africa (n = 10), Europe (n = 10) and from unknown regions (n = 2) were analysed with amplified fragment length polymorphism fingerprinting (AFLP) to reveal intraspecific genetic diversity in this dataset. Read More

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http://doi.wiley.com/10.1111/myc.12889
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http://dx.doi.org/10.1111/myc.12889DOI Listing
May 2019
17 Reads

Clinical characteristics, rapid identification, molecular epidemiology and antifungal susceptibilities of Talaromyces marneffei infections in Shenzhen, China.

Mycoses 2019 May;62(5):450-457

Department of Microbiology, Li Ka Shing Faculty of Medicine, The University of Hong Kong, Pokfulam, Hong Kong.

Although case series of talaromycosis have been reported in China, their detailed clinical and microbiological characteristics have never been systematically profiled. In this study, we report the clinical characteristics, molecular epidemiology, rapid identification and antifungal susceptibilities of talaromycosis in The University of Hong Kong-Shenzhen Hospital in Shenzhen. Seven cases of talaromycosis were observed since commencement of hospital service in 2012. Read More

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http://dx.doi.org/10.1111/myc.12887DOI Listing
May 2019
1 Read

Candida auris otomycosis in Iran and review of recent literature.

Mycoses 2019 Feb;62(2):101-105

Department of Medical Mycology/Invasive Fungi Research Center (IFRC), School of Medicine, Mazandaran University of Medical Sciences, Sari, Iran.

Candida auris is a multidrug-resistant yeast emerging in immunocompromised and in otherwise healthy individuals. Due to difficulties in microbiological identification of C. auris because of the lack of available laboratory technology in developing countries, the number of patients affected is most likely underestimated. Read More

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http://dx.doi.org/10.1111/myc.12886DOI Listing
February 2019
1 Read
1.805 Impact Factor

Isavuconazole and voriconazole for the treatment of chronic pulmonary aspergillosis: A retrospective comparison of rates of adverse events.

Mycoses 2019 Mar 15;62(3):217-222. Epub 2019 Jan 15.

Division of Infection, Immunity and Respiratory Medicine, Faculty of Biology, Medicine and Health, University of Manchester, Manchester, UK.

Background: Long-term oral triazole antifungal therapy is the cornerstone of management for patients with chronic pulmonary aspergillosis (CPA). Itraconazole is the first-line choice of treatment. Voriconazole, posaconazole or isavuconazole can be used as alternative treatments in case of resistance or intolerance. Read More

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http://dx.doi.org/10.1111/myc.12885DOI Listing
March 2019
3 Reads
1.805 Impact Factor

Cryptococcal meningitis is a cause for cross-reactivity in cerebrospinal fluid assays for anti-Histoplasma, anti-Coccidioides and anti-Blastomyces antibodies.

Mycoses 2019 Mar 1;62(3):268-273. Epub 2019 Jan 1.

MiraVista Diagnostics, Indianapolis, Indianapolis, Indiana.

Background/objectives: Antibody detection is commonly used for diagnosis of histoplasmosis, and cross-reactions have been recognised due to endemic mycoses but not cryptococcosis. We observed cross-reactions in an anti-Histoplasma antibody enzyme immunoassay (EIA) in the cerebrospinal fluid (CSF) from a patient with cryptococcal meningitis and sought to assess the risk of cross-reactive anti-Histoplasma antibodies in persons with cryptococcal meningitis.

Methods: An anti-cryptococcal antibody EIA was developed to measure CSF antibody response in HIV-infected subjects from Kampala, Uganda and previously healthy, HIV-negative subjects at the National Institutes of Health (NIH) with cryptococcal meningitis. Read More

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http://dx.doi.org/10.1111/myc.12882DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6380936PMC
March 2019
8 Reads

Randomised clinical trial in women with Recurrent Vulvovaginal Candidiasis: Efficacy of probiotics and lactoferrin as maintenance treatment.

Mycoses 2019 Apr 20;62(4):328-335. Epub 2019 Feb 20.

Department of Medical Science, University of Trieste, Trieste, Italy.

Background: Vulvovaginal candidiasis (VVC) is a recurrent vaginal condition in childbearing women.

Objectives: The aim of this study was to assess the efficacy of an oral formulation containing Lactobacillus acidophilus GLA-14, Lactobacillus rhamnosus HN001 and bovine lactoferrin on symptoms and recurrence of VVC as adjuvant therapy to topical clotrimazole.

Patients/methods: Forty-eight women positive for C. Read More

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http://doi.wiley.com/10.1111/myc.12883
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http://dx.doi.org/10.1111/myc.12883DOI Listing
April 2019
9 Reads

Fungal infections of the central nervous system and paranasal sinuses in onco-haematologic patients. Epidemiological study reporting the diagnostic-therapeutic approach and outcome in 89 cases.

Mycoses 2019 Mar 22;62(3):252-260. Epub 2019 Jan 22.

Istituto di Ematologia, Polo Onco-Ematologico Fondazione Policlinico A. Gemelli-IRCCS, Università Cattolica del Sacro Cuore, Roma, Italy.

Invasive fungal infections (IFI) of the Central Nervous System (IFI-CNS) and Paranasal Sinuses (IFI-PS) are rare, life-threatening infections in haematologic patients, and their management remains a challenge despite the availability of new diagnostic techniques and novel antifungal agents. In addition, analyses of large cohorts of patients focusing on these rare IFI are still lacking. Between January 2010 and December 2016, 89 consecutive cases of Proven (53) or Probable (36) IFI-CNS (71/89) and IFI-PS (18/89) were collected in 34 haematological centres. Read More

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http://dx.doi.org/10.1111/myc.12884DOI Listing
March 2019
4 Reads

Point-of-care diagnosis of invasive aspergillosis in non-neutropenic patients: Aspergillus Galactomannan Lateral Flow Assay versus Aspergillus-specific Lateral Flow Device test in bronchoalveolar lavage.

Mycoses 2019 Mar 15;62(3):230-236. Epub 2019 Jan 15.

Department of Medicine, University of California San Diego, San Diego, California.

Background: We compared new Aspergillus Galactomannan Lateral Flow Assay with the newly formatted Aspergillus-specific Lateral Flow device tests for the diagnosis of invasive pulmonary aspergillosis (IPA) in non-neutropenic patients.

Methods: We performed both tests in 82 bronchoalveolar lavage fluid samples from 82 patients at risk for IPA but without underlying haematologic malignancy. Samples were collected between September 2016 and September 2018 at the University of California San Diego, United States. Read More

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http://dx.doi.org/10.1111/myc.12881DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6380940PMC
March 2019
3 Reads

Role of western blot assay for the diagnosis of histoplasmosis in AIDS patients from a National Institute of Infectious Diseases in Rio de Janeiro, Brazil.

Mycoses 2019 Mar 22;62(3):261-267. Epub 2019 Jan 22.

Instituto Nacional de Infectologia Evandro Chagas, Fundação Oswaldo Cruz, Rio de Janeiro, RJ, Brazil.

Background: Histoplasmosis is a frequent fungal infection in HIV/AIDS patients, with high morbimortality rates when diagnosis and treatment are delayed. Antibody detection, which is faster than the gold standard culture test, hastens the laboratory investigation.

Objectives: To evaluate the role of WB for antibody detection in the diagnosis of histoplasmosis among HIV/AIDS patients. Read More

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http://dx.doi.org/10.1111/myc.12877DOI Listing
March 2019
4 Reads

The current Indian epidemic of superficial dermatophytosis due to Trichophyton mentagrophytes-A molecular study.

Mycoses 2019 Apr 20;62(4):336-356. Epub 2019 Feb 20.

Laboratory for Medical Microbiology, Mölbis, Germany.

The disease burden of chronic-relapsing and therapy-refractory superficial dermatophytosis dramatically increased in India within the past 5-6 years. In order to evaluate the prevalence of this trend, 201 skin scrapings were collected from patients from all parts of India and were tested for dermatophytes using both fungal culture and a PCR-ELISA directly performed with native skin scrapings. Fungal culture material was identified by genomic Sanger sequencing of the internal transcribed spacer (ITS) region and the translation elongation factor (TEF)-1α gene. Read More

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http://doi.wiley.com/10.1111/myc.12878
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http://dx.doi.org/10.1111/myc.12878DOI Listing
April 2019
6 Reads

Microbiological characterisation of the colonisation by Candida sp in patients with orthodontic fixed appliances and evaluation of host responses in saliva.

Mycoses 2019 Mar 15;62(3):247-251. Epub 2019 Jan 15.

Programa de Microbiología y Micología, ICBM, Facultad de Medicina, Universidad de Chile, Santiago, Chile.

Objectives: We investigated the colonisation by Candida spp in patients using orthodontic fixed appliances by characterising the isolated Candida strains and by evaluating the host oral mucosa response through the measure of human β-defensins 3 (HBD-3) expression and Interleukin-1ß/IL-10.

Methods: Ninety patients were enrolled after signing an informed consent. Prevalence, susceptibility to fluconazole, genotyping and oral fungal burden of Candida sp. Read More

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http://dx.doi.org/10.1111/myc.12880DOI Listing
March 2019
3 Reads

A randomised trial of vitamin D in acute-stage allergic bronchopulmonary aspergillosis complicating asthma.

Mycoses 2019 Apr 5;62(4):320-327. Epub 2019 Feb 5.

Department of Pulmonary Medicine, Postgraduate Institute of Medical Education and Research (PGIMER), Chandigarh, India.

Vitamin D has been demonstrated to have an immunomodulatory role in cystic fibrosis with allergic bronchopulmonary aspergillosis (ABPA). Herein, we evaluate supplemental vitamin D in acute-stage ABPA complicating asthma. Thirty subjects were randomised to receive either prednisolone (n = 15, control) or prednisolone and oral vitamin D (n = 15, intervention arm). Read More

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http://doi.wiley.com/10.1111/myc.12879
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http://dx.doi.org/10.1111/myc.12879DOI Listing
April 2019
18 Reads
1.805 Impact Factor

Rhodotorula infection in haematological patient: Risk factors and outcome.

Mycoses 2019 Mar 28;62(3):223-229. Epub 2018 Dec 28.

Institute of Hematology, Fondazione Policlinico A. Gemelli - IRCCS-Università Cattolica del Sacro Cuore, Rome, Italy.

Background: Rhodotorula spp are uncommon yeasts able to cause infections with high mortality rates. Rhodotorula infections have been associated with the presence of central venous catheter (CVC), immunosuppression, exposure to antifungals and the presence of either solid or haematologic malignancies. However, in this latter setting, only a few cases have so far been reported. Read More

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http://dx.doi.org/10.1111/myc.12875DOI Listing
March 2019
18 Reads

The host range of dermatophytes, it is at all possible? Phenotypic evaluation of the keratinolytic activity of Trichophyton verrucosum clinical isolates.

Mycoses 2019 Mar 1;62(3):274-283. Epub 2019 Jan 1.

State Veterinary Laboratory, Lublin, Poland.

Dermatophytes are fungi that have an ability to invade keratinised structures. Enzymes secreted by dermatophytes can underlie fungal survival on the host and development of infection. It is possible that the range of activity of keratinases from various dermatophytes is limited to specific species of animals and groups of people. Read More

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http://dx.doi.org/10.1111/myc.12876DOI Listing
March 2019
2 Reads

Can intravenous antifungal therapy be safely used in the outpatient parenteral antimicrobial therapy (OPAT) setting?

Mycoses 2019 Mar 22;62(3):196-203. Epub 2019 Jan 22.

Department of Infectious Diseases, Mater Misericordiae University Hospital, Dublin, Ireland.

Outpatient parenteral antimicrobial therapy (OPAT) is an established treatment option for patients with a variety of infections who require a period of intravenous therapy, are clinically stable, and do not require continuous monitoring. Many patients with fungal infections require prolonged therapy due to resistance or intolerance to oral antifungal agents. Despite the widespread use of OPAT by infection specialists, antifungal agents appear infrequently used in this setting. Read More

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http://dx.doi.org/10.1111/myc.12874DOI Listing
March 2019
3 Reads

Outcome and potentially modifiable risk factors for candidemia in critically ill burns patients: A matched cohort study.

Mycoses 2019 Mar 18;62(3):237-246. Epub 2018 Dec 18.

Department of Anesthesiology and Critical Care and Burn Unit, AP-HP, Hôpital Saint-Louis, Paris, France.

Background: Patients with extensive burns are at risk of developing candidemia.

Objectives: To identify potentially modifiable risk factors and outcomes of candidemia in critically ill burns patients.

Patients And Methods: Retrospective matched cohort study including adult burns patients. Read More

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http://doi.wiley.com/10.1111/myc.12872
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http://dx.doi.org/10.1111/myc.12872DOI Listing
March 2019
18 Reads
1.805 Impact Factor

Managing liver dysfunction in haematology patients: Switch antifungals, or use the tincture of time?

Mycoses 2019 Mar 18;62(3):214-216. Epub 2018 Dec 18.

Michigan Medicine Department of Pharmacy, The University of Michigan College of Pharmacy, Ann Arbor, Michigan.

Liver function test (LFT) abnormalities are a common occurrence in haematology patients receiving antifungal therapies. The cause of elevated LFTs is often multifactorial. Posaconazole is associated with elevated LFTs in approximately 5%-10% of patients. Read More

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http://dx.doi.org/10.1111/myc.12871DOI Listing
March 2019
1 Read
1.805 Impact Factor

Evaluation of drug susceptibility test for Efinaconazole compared with conventional antifungal agents.

Mycoses 2019 Mar 17;62(3):291-297. Epub 2018 Dec 17.

Department of Dermatology, Konkuk University School of Medicine, Seoul, Korea.

Background: Superficial fungal infections are one of the most common and burdensome skin problems affecting quality of life in patients. Various conventional antifungal agents have been used to treat fungal infections; however, various problems have been reported including drug interaction, drug resistance and low effectiveness. Efinaconazole is a novel antifungal agent, which has proven to be particularly effective against onychomycosis compared with conventional antifungal agents. Read More

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http://dx.doi.org/10.1111/myc.12870DOI Listing
March 2019
2 Reads

Developing definitions for invasive fungal diseases in critically ill adult patients in intensive care units. Protocol of the FUNgal infections Definitions in ICU patients (FUNDICU) project.

Mycoses 2019 Apr 22;62(4):310-319. Epub 2019 Jan 22.

Infectious Diseases Service, Department of Medicine, Lausanne University, Lausanne, Switzerland.

Background: The reliability of diagnostic criteria for invasive fungal diseases (IFD) developed for severely immunocompromised patients is questionable in critically ill adult patients in intensive care units (ICU).

Objectives: To develop a standard set of definitions for IFD in critically ill adult patients in ICU.

Methods: Based on a systematic literature review, a list of potential definitions to be applied to ICU patients will be developed by the ESCMID Study Group for Infections in Critically Ill Patients (ESGCIP) and the ESCMID Fungal Infection Study Group (EFISG) chairpersons. Read More

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http://doi.wiley.com/10.1111/myc.12869
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http://dx.doi.org/10.1111/myc.12869DOI Listing
April 2019
11 Reads

First-time isolation and quantification of Basidiobolus spp. from reptile faeces in KwaZulu-Natal (South Africa) using selective media.

Mycoses 2019 Mar 23;62(3):298-305. Epub 2018 Nov 23.

Discipline of Microbiology, School of Life Sciences, University of KwaZulu-Natal, Pietermaritzburg, South Africa.

Members of the genus Basidiobolus are potentially pathogenic fungi, known to cause mycoses in tropical and subtropical countries. Basidiobolus spp. can be associated with animals, and reptiles and amphibians are candidate vectors for the distribution of this fungus. Read More

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http://doi.wiley.com/10.1111/myc.12868
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http://dx.doi.org/10.1111/myc.12868DOI Listing
March 2019
4 Reads

False positive bronchoalveolar lavage galactomannan: Effect of host and cut-off value.

Mycoses 2019 Mar 25;62(3):204-213. Epub 2018 Nov 25.

Brigham and Women's Hospital, Rhode Island Hospital, Division of Infectious Diseases, Harvard Medical School, Boston, Massachusetts.

Objectives: Bronchoalveolar lavage galactomannan (BAL-GM) is a mycological criterion for diagnosis of probable invasive aspergillosis (IA) per European Organization for Research and Treatment of Cancer/Mycoses Study Group (EORT-MSG) consensus criteria, but its real-world positive predictive value (PPV) has not been well-studied. Our aim was to estimate the PPV of BAL-GM in a contemporary cohort of patients with positive BAL-GM.

Methods: We identified consecutive patients with ≥1 positive BAL-GM value (index ≥ 0. Read More

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http://dx.doi.org/10.1111/myc.12867DOI Listing
March 2019
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Perspectives on misidentification of Trichophyton interdigitale/Trichophyton mentagrophytes using internal transcribed spacer region sequencing: Urgent need to update the sequence database.

Mycoses 2019 Jan 15;62(1):11-15. Epub 2018 Nov 15.

Department of Medical Microbiology and Infectious Diseases, Canisius-Wilhelmina Hospital, Nijmegen, The Netherlands.

The taxonomy of the dermatophytes has been revisited using a novel multilocus phylogenetic approach, and several neotypes and reference strains have been assigned for Trichophyton species. Single gene sequencing, that is the ITS region, for identification of highly related species T. mentagrophytes/T. Read More

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http://dx.doi.org/10.1111/myc.12865DOI Listing
January 2019
6 Reads
1.805 Impact Factor