Search Our Scientific Publications & Authors

Genomics 2021 Jun 9. Epub 2021 Jun 9.

Department of Immunology, Microbiology and Parasitology, Universidade Federal do Triângulo Mineiro, Uberaba, Minas Gerais, Brazil. Electronic address:

Mycoplasma genitalium is an obligate intracellular bacterium that is responsible for several sexually transmitted infections, including non-gonococcal urethritis in men and several inflammatory reproductive tract syndromes in women. Here, we applied subtractive genomics and reverse vaccinology approaches for in silico prediction of potential vaccine and drug targets against five strains of M. genitalium. Read More

Sex Transm Dis 2021 Mar 13. Epub 2021 Mar 13.

1Sorbonne University, INSERM, Pierre Louis Epidemiology and Public Health Institute (iPLESP), AP-HP, Pitié-Salpêtrière Hospital, Department of Infectious Diseases, F-75013 Paris, France 2CHU Bordeaux, Bacteriology Department, National Reference Center for bacterial sexually transmitted infections, F-33000 Bordeaux, France 3Bordeaux University, USC EA 3671 Mycoplasmal and Chlamydial Infections in Humans, F-33000 Bordeaux, France 4INRAE, USC EA 3671 Mycoplasmal and Chlamydial Infections in Humans, F-33000 Bordeaux, France.

We present a case of persistent Mycoplasma genitalium (MG) urethritis with documented macrolide and fluoroquinolone resistance, and we describe the A2062T mutation in the 23S rRNA gene, possibly associated with pristinamycin resistance. After several treatment failures and loss of the A2062T mutation, MG urethritis was finally cured by a sequential antibiotic treatment including minocycline. Read More

Eur J Clin Microbiol Infect Dis 2021 Jun 9. Epub 2021 Jun 9.

Mikrobiologisches Institut-Klinische Mikrobiologie, Immunologie und Hygiene, Universitätsklinikum Erlangen und Friedrich-Alexander-Universität (FAU) Erlangen-Nürnberg, Wasserturmstr. 3/5, 91054, Erlangen, Germany.

SARS-CoV-2 antibody assays are used for epidemiological studies and for the assessment of vaccine responses in highly vulnerable patients. So far, data on cross-reactivity of SARS-CoV-2 antibody assays is limited. Here, we compared four enzyme-linked immunosorbent assays (ELISAs; Vircell SARS-CoV-2 IgM/IgA and IgG, Euroimmun SARS-CoV-2 IgA and IgG) for detection of anti-SARS-CoV-2 antibodies in 207 patients with COVID-19, 178 patients with serological evidence of different bacterial infections, 107 patients with confirmed viral respiratory disease, and 80 controls from the pre-COVID-19 era. Read More

Mol Med Rep 2021 Aug 10;24(2). Epub 2021 Jun 10.

Department of Microbiology and Parasitology, China Medical University, Shenyang, Liaoning 110001, P.R. China.

(MP) is a common pathogen that can cause respiratory infections. MP pneumonia (MPP) leads to numerous complications, including lung injury and even death. The present study aimed to investigate the protective effects of Baicalin treatment on MP infection‑induced lung injury and the molecular mechanism underlying these effects. Read More

Int J STD AIDS 2021 Jun 9:9564624211022583. Epub 2021 Jun 9.

The Kirby Institute, UNSW Sydney, Sydney, NSW, Australia.

() is associated with urethritis, cervicitis, pelvic inflammatory disease, proctitis and epididymitis. Its treatment is complicated by antimicrobial resistance. To assess clinicians' adherence to diagnostic testing recommendations for syndromic presentations, as well as resistance-guided management of at Sydney Sexual Health Centre, we reviewed patients presenting between August and December 2018. Read More

Int J Mol Epidemiol Genet 2021 15;12(2):16-23. Epub 2021 Apr 15.

Department of Pathology and Laboratory Medicine, American University of Beirut Medical Center Beirut, Lebanon.

Background: Sexually transmitted diseases (STD) are caused by a variety of pathogens transmitted by sexual activity. Untreated infections can cause major complications with a substantial high cost on health sector. With the development of molecular techniques, STD screening became easier with a high sensitivity and specificity. Read More

Vet Microbiol 2021 May 27;259:109135. Epub 2021 May 27.

Department of Veterinary and Animal Science University of Copenhagen, Copenhagen, Denmark. Electronic address:

Bovine respiratory disease (BRD) is caused by a mixture of viruses and opportunistic bacteria belonging to Pasteurellaceae and Mycoplasma bovis. However, these organisms are also commonly isolated from healthy calves. This study aimed to determine whether the organisms are present in higher numbers in calves sick with acute BRD than in clinically healthy calves, and further to genetically characterize bacteria of the family Pasteurellaceae to understand whether particular types are associated with disease. Read More

Sex Transm Infect 2021 Jun 4. Epub 2021 Jun 4.

Antimicrobial Resistance and Healthcare Associated Infections (AMRHAI), National Infection Service, Public Health England, London, UK.

Objectives: This study sought to provide data on the prevalence of macrolide (23S rRNA) and fluoroquinolone () resistance-associated mutations seen in -positive specimens received in the UK national reference laboratory.

Methods: In total, 2580 clinical specimens from patients with suspected or confirmed infection were received at the national reference laboratory between September 2017 and November 2018. -positive clinical specimens were identified using a reverse transcription-PCR targeting two genes: and . Read More

Vet World 2021 Apr 19;14(4):943-948. Epub 2021 Apr 19.

Center for Agricultural Biotechnology, Kasetsart University, Kamphaeng Saen Campus, Nakhon Pathom, Thailand.

Background And Aim: Hemoplasmas are defined as small, epicellular parasitic bacteria that can infect the red blood cells of several mammalian species. Diseases caused by these bacteria range from asymptomatic infections to acute hemolytic anemia. However, data on hemoplasmas in non-human primates in Thailand remain to be limited. Read More

J Int Med Res 2021 Jun;49(6):3000605211016376

Department of Respiratory Medicine, Children's Hospital of Nanjing Medical University, Nanjing, China.

Objective: To investigate the prevalence of mutations in domain V of (MP) 23S ribosomal RNA (rRNA) and the clinical characteristics of pediatric MP pneumonia (MPP) in Nanjing, China.

Methods: Domain V of 23S rRNA was sequenced in MP strains collected from children diagnosed with MPP in Nanjing. Clinical and laboratory data were obtained. Read More

Animals (Basel) 2021 May 26;11(6). Epub 2021 May 26.

INVESAGA Group, Department of Animal Pathology, Faculty of Veterinary Sciences, Universidade de Santiago de Compostela, Avd. Carballo Calero s/n, 27002 Lugo, Spain.

Porcine Circovirus Type 2 (PCV2) and are economically important pathogens in swine farms. Vaccination is the main preventive measure for both infections. In order to test two ready-to-use bivalent vaccines, 646 piglets from a herd actively infected with both pathogens were stratified according to the sow parity number and randomly assigned to three groups: A and B were vaccinated with two different vaccines, respectively, while C remained as the unvaccinated control. Read More

Trop Med Infect Dis 2021 May 27;6(2). Epub 2021 May 27.

Laboratory of Molecular Biology and Molecular Genetics (LABIOGENE), Ouagadougou BP 7021, Burkina Faso.

Viral and bacterial infections represent an occupational risk for female sex workers. This study aimed at determining HPV coinfection with genital pathogens among female sex workers in West and Central Africa and identifying antibiotic resistance genes. A total of 182 samples from female sex workers were analyzed by real-time PCR and classic PCR. Read More

Microorganisms 2021 May 30;9(6). Epub 2021 May 30.

Department of Genetics and Cell Biology, Institute for Public Health Genomics (IPHG), Faculty of Health, Medicine & Life Sciences, Research School GROW (School for Oncology & Developmental Biology), University of Maastricht, 6229 ER Maastricht, The Netherlands.

This study aimed to determine the persistence of (CT), (NG), (TV) and (MG) infections during pregnancy and after delivery in vaginal swabs of women from Pemba Island, Tanzania. In the context of an earlier biobanking effort, vaginal swabs were collected at two timepoints during pregnancy and once post-delivery. Detection of CT, NG, TV, and MG was performed by PCR using validated detection kits in samples from 441 pregnant women aged 16-48 years old. Read More

Pathogens 2021 May 14;10(5). Epub 2021 May 14.

IRTA, Centre de Recerca en Sanitat Animal (CReSA, IRTA-UAB), Campus de la Universitat Autònoma de Barcelona, 08193 Bellaterra, Spain.

Fibrinous polyserositis in swine farming is a common pathological finding in nursery animals. The differential diagnosis of this finding should include (aetiological agent of Glässer's disease) and , among others. These microorganisms are early colonizers of the upper respiratory tract of piglets. Read More

Diagnostics (Basel) 2021 May 14;11(5). Epub 2021 May 14.

Department of Biochemistry and Biopharmaceuticals, National Medicines Institute (NMI), 00-725 Warsaw, Poland.

, , and sp. are atypical bacteria responsible for in vitro cell culture contaminations that can warp the results. These bacteria also cause human and animal infections and may lead to chronic diseases. Read More

Pathogens 2021 May 6;10(5). Epub 2021 May 6.

Department of Parasitology, Faculty of Veterinary Medicine, Kasetsart University, Bangkok 10900, Thailand.

Canine tick-borne pathogens (CTBPs) such as , , , and are important pathogens in dogs worldwide. sensu lato, the main vector of several CTBPs, is the most common tick species found on dogs in Thailand. The present study identified CTBPs in dogs and ticks infested dogs. Read More

J Eur Acad Dermatol Venereol 2021 May 31. Epub 2021 May 31.

Department of Sexual Health and HIV, Birmingham University Hospitals NHS Foundation Trust, Birmingham, UK.

This guideline intents to offer guidance on the diagnosis and management of patients with gastrointestinal symptoms and a suspected sexually transmitted cause. Proctitis is defined as an inflammatory syndrome of the anal canal and/or the rectum. Infectious proctitis can be sexually transmitted via genital-anal mucosal contact, but some also via digital contact and toys. Read More

Mol Clin Oncol 2021 Jul 9;15(1):132. Epub 2021 May 9.

Clinical Laboratory, Zhongshan Hospital Affiliated to Fudan University Wusong Hospital, Shanghai 200940, P.R. China.

Cervical cancer, one of the high-incidence female malignant tumors, has predominated in recent years. Persistent infection with high-risk human papillomavirus (HR-HPV) is the main cause of cervical cancer. Studies have shown that infection with certain sexually transmitted disease (STD) pathogens increases the risk of persistent infection with HR-HPV and is a high-risk factor for cervical cancer. Read More

Vet Clin North Am Food Anim Pract 2021 Jul;37(2):295-308

Department of Population Health & Reproduction, School of Veterinary Medicine, University of California Davis, 1 Shields Avenue, VM3B, Davis, CA 95616, USA.

Infectious bovine keratoconjunctivitis (IBK) is a multifactorial disease complex caused by opportunistic pathogens, classically those members of the genus Moraxella. However, IBK in some situations is associated with other potentially pathogenic agents, which include Mycoplasma bovoculi, Mycoplasma bovis, Ureaplasma diversum, bovine herpesviruses, and Chlamydia sp. Ocular infections that may resemble IBK are also caused by Listeria monocytogenes. Read More

Sci Rep 2021 May 27;11(1):11087. Epub 2021 May 27.

China Australia Joint Research Center for Infectious Diseases, School of Public Health, Xi'an Jiaotong University Health Science Centre, Xi'an, 710061, Shaanxi, People's Republic of China.

Mycoplasma genitalium (M. genitalium) is a recently recognised and important sexually transmitted infection among men who have sex with men (MSM). The role of oral sex, rimming, and kissing on M. Read More

BMC Infect Dis 2021 May 26;21(1):482. Epub 2021 May 26.

CHU Réunion, Service des Maladies Infectieuses - Dermatologie, Saint Pierre, La Réunion, France.

Background: Mycoplasma genitalium (MG) is an emerging sexually transmitted infection (STI) for whose management remains controversial. We aimed to assess the prevalence and risk factors of MG infection in patients attending an STI clinic in Reunion Island.

Methods: Between January 2017 and December 2018, all patients attending the Saint-Pierre STI clinic in Reunion Island were screened for MG, Chlamydia trachomatis (CT) and Neisseria gonorrhoeae (NG). Read More

J Med Microbiol 2021 May;70(5)

Department of Rehabilitation Medicine, NYU Grossman School of Medicine, New York, NY, USA.

experimentation is intentionally contrived to isolate specific phenomena in the context of profound biological complexity. Mycoplasmas in the upper airway likely contribute to this complexity and play a largely unknown role in both health and disease. Similarly, the presence and role of mycoplasma in investigation are largely unknown. Read More

J Int Med Res 2021 May;49(5):3000605211015579

Children's Hospital of Wujiang District, Suzhou, China.

Objective: To determine the risk factors for delayed radiographic resolution in children with refractory pneumonia (RMPP) and explore the most suitable time for interventional bronchoscopy.

Methods: This retrospective study involved 142 children with RMPP who were admitted to our hospital from 1 January 2015 to 31 December 2017. They were divided into a common resolution group and a delayed resolution group based on their chest radiograph series. Read More

Zhonghua Yu Fang Yi Xue Za Zhi 2021 May;55(5):660-666

Graduate School of Peking Union Medical College, Chinese Academy of Medical Sciences, Beijing 100070, China Department of Pediatrics, China-Japan Friendship Hospital, Beijing 100029, China.

This study was aimed to analyze the untargeted metabolomics of serum samples from children with mycoplasma pneumonia in a hospital in Beijing. A total of 50 children with mycoplasma pneumonia as the case group were recruited from Department of Pediatrics, China-Japan Friendship Hospital in Beijing from January 2019 to February 2020, and meanwhile 50 age-and gender-matched heathy children were selected and formed the control group. 2 ml venous fasting blood samples was collected from all children. Read More

J Microbiol Methods 2021 Jul 21;186:106250. Epub 2021 May 21.

Second School of Clinical Medicine, Guangzhou University of Chinese Medicine, Guangzhou 510405, China; Department of Laboratory Medicine, the Second Affiliated Hospital of Guangzhou University of Chinese Medicine, Guangzhou 510120, China. Electronic address:

Introduction: Rapid, sensitive, and specific diagnostic methods are indispensable for sexually transmitted infections (STIs). In this study, a multiplex PCR-dipstick DNA chromatography assay for diagnosis of four STI pathogens, namely Neisseria gonorrhoeae (N. gonorrhoeae), Mycoplasma hominis (M. Read More

Vet Microbiol 2021 Jul 15;258:109123. Epub 2021 May 15.

São Paulo State University, School of Agricultural and Veterinarian Sciences, Jaboticabal, São Paulo, Brazil. Electronic address:

Infections with Mycoplasma hyopneumoniae (Mhyo), Mycoplasma hyorhinis (Mhr) and Mycoplasma flocculare (Mfloc) are common in swine. However, the degree of co-infections and the correlations between these mycoplasma co-infection and the severity of macroscopic lung consolidation lesions (MLCL) have not yet been explored in Brazil.The objectives were to quantify Mhyo, Mhr, and Mfloc in MLCL of slaughter pigs in Brazil, and to assess correlations with the degree of MLCL in slaughter pigs. Read More

Zhongguo Dang Dai Er Ke Za Zhi 2021 May;23(5):471-474

Department of Pediatrics, Guangdong Women and Children's Hospital, Guangzhou 510010, China.

Objective: To evaluate the value of chitinase-like protein YKL-40 in bronchoalveolar lavage fluid (BALF) for predicting refractory pneumonia (RMPP) in children.

Methods: A total of 50 children with common pneumonia (MPP) and 22 children with RMPP were enrolled. The two groups were compared in terms of clinical features, laboratory examination results, imaging findings, and YKL-40 levels in BALF. Read More

Emerg Infect Dis 2021 Jun;27(6):1588-1597

Emergence of macrolide-resistant Mycoplasma pneumoniae (MRMp) challenges empiric macrolide therapy. Our goal was to determine MRMp rates and define characteristics of children infected with macrolide-sensitive M. pneumoniae (MSMp) versus MRMp in Ohio, USA. Read More

Transl Pediatr 2021 Apr;10(4):990-997

Department of Pediatric Pulmonology, Chengdu Women's and Children's Central Hospital, School of Medicine, University of Electronic Science and Technology of China, Chengdu, China.

Background: Respiratory tract infection (RTIs) is one of common diseases among the children. In recent years, the incidence of () infection rate has been increasing, which cause respiratory tract infection. This study sought to analyze the epidemiological characteristics of hospitalized children with RTIs to provide a theoretical basis for clinical diagnosis and treatments in Chengdu, China. Read More

Transl Pediatr 2021 Apr;10(4):984-989

Department of Pediatric Respiratory Medicine, Chengdu Women's and Children's Central Hospital, School of Medicine, University of Electronic Science and Technology of China, Chengdu, China.

Background: To analyze and summarize the etiological distribution of pertussis-like syndrome in children and to provide a basis for clinical treatment.

Methods: A retrospective analysis was conducted of 756 children with pertussis-like syndrome hospitalized at the Department of Pediatric Respiratory Medicine of Chengdu Women's and Children's Central Hospital, 2015 to 2019. The etiological features were classified and reviewed. Read More