25,224 results match your criteria Mycoplasma Infections


Comparative Analysis of vlhA Promoters.

Front Genet 2018 21;9:569. Epub 2018 Nov 21.

Institute of Cell Biophysics, Russian Academy of Sciences, Pushchino, Russia.

is an intracellular parasite affecting respiratory tract of poultry that belongs to class Mollicutes. features numerous variable lipoprotein hemagglutinin genes (vlhA) that play a role in immune escape. The vlhA promoters have a set of distinct properties in comparison to promoters of the other genes. Read More

View Article
November 2018
1 Read

Increased Total Serum Immunoglobulin E in Children Developing Mycoplasma pneumoniae-related Extra-pulmonary Diseases.

Iran J Allergy Asthma Immunol 2018 Oct 9;17(5):490-496. Epub 2018 Oct 9.

Department of Pediatrics, IRCCS Fondazione Policlinico San Matteo e Universita' Degli Studi di Pavia, Pavia, Italy AND Department of Pediatrics, ASST Melegnano e Martesana, Vizzolo Predabissi, Milano, Italy.

Mycoplasma pneumoniae has been recognized to be involved in several extra-pulmonary diseases, but the underlying immunologic mechanisms are still largely unknown. Recently, we observed a significant elevation of serum Immunoglobulin E (IgE) in a small group of these children. Here, we assessed total serum IgE levels in children affected with Mycoplasma pneumoniae-related extra-pulmonary diseases. Read More

View Article
October 2018

Detection of Mycoplasma Contamination of Cell Culture by A Loop-Mediated Isothermal Amplification Method.

Cell J 2019 Apr 18;21(1):43-48. Epub 2018 Nov 18.

Tasnim Biotechnology Research Center (TBRC), Faculty of Medicine, AJA University of Medical Sciences, Tehran, Iran.

Objective: Mycoplasmas are major contaminants of cell culture and affect in vitro biological and diagnostic tests. Mycoplasma detection is conducted using culture and molecular methods. These methods vary in terms of accuracy, reliably and sensitivity. Read More

View Article
April 2019
1 Read

[A multicenter clinical study on 1 138 cases of invasive pneumococcal disease in children from 2012 to 2017].

Zhonghua Er Ke Za Zhi 2018 Dec;56(12):915-922

Zunyi Medical University, Zunyi 563003, China.

To explore the clinical features, the serotype distribution and drug resistance of the isolates in patient with invasive pneumococcal disease (IPD). By retrieving the laboratory information system in 18 children's hospitals from 2012 to 2017, the children with IPD were enrolled. (Spn) must be isolated from the sterile sites (blood, cerebrospinal fluid, hydrothorax and joint effusion etc. Read More

View Article
December 2018
4 Reads

Pathogenesis and Treatment of Neurologic Diseases Associated With Infection.

Front Microbiol 2018 20;9:2751. Epub 2018 Nov 20.

Pediatric Clinic, Department of Surgical and Biomedical Sciences, Università degli Studi di Perugia, Perugia, Italy.

is mainly recognized as a respiratory pathogen, although it is associated with the development of several extra-respiratory conditions in up to 25% of the cases. Diseases affecting the nervous system, both the peripheral (PNS) and the central nervous system (CNS), are the most severe. In some cases, particularly those that involve the CNS, -related neuropathies can lead to death or to persistent neurologic problems with a significant impact on health and a non-marginal reduction in the quality of life of the patients. Read More

View Article
November 2018

Analysis of the gut and gill microbiome of resistant and susceptible lines of rainbow trout (Oncorhynchus mykiss).

Fish Shellfish Immunol 2018 Dec 1. Epub 2018 Dec 1.

University of New Mexico, Department of Biology, Center for Evolutionary and Theoretical Immunology (CETI), Albuquerque, NM, USA. Electronic address:

Commensal microorganisms present at mucosal surfaces play a vital role in protecting the host organism from bacterial infection. There are multiple factors that contribute to selecting for the microbiome, including host genetics. Flavobacterium psychrophilum, the causative agent of Bacterial Cold Water Disease in salmonids, accounts for acute losses in wild and farmed Rainbow Trout (Oncorhynchus mykiss). Read More

View Article
December 2018
1 Read

Etiology of Coinfections in Children with Influenza during 2015/16 Winter Season in Nepal.

Int J Microbiol 2018 28;2018:8945142. Epub 2018 Oct 28.

Central Department of Microbiology, Tribhuvan University, Kirtipur, Nepal.

Acute respiratory infections (ARIs) are one of the major public health problems in developing countries like Nepal. Besides the influenza, several other pathogens are responsible for acute respiratory infection in children. Etiology of infections is poorly characterized at the course of clinical management, and hence empirical antimicrobial agents are used. Read More

View Article
October 2018
2 Reads

Mycoplasma promotes malignant transformation in vivo, and its DnaK, a bacterial chaperon protein, has broad oncogenic properties.

Proc Natl Acad Sci U S A 2018 Dec 3. Epub 2018 Dec 3.

Institute of Human Virology, School of Medicine, University of Maryland, Baltimore, MD 21201;

We isolated a strain of human mycoplasma that promotes lymphomagenesis in SCID mice, pointing to a p53-dependent mechanism similar to lymphomagenesis in uninfected p53 SCID mice. Additionally, mycoplasma infection in vitro reduces p53 activity. Immunoprecipitation of p53 in mycoplasma-infected cells identified several mycoplasma proteins, including DnaK, a member of the Hsp70 chaperon family. Read More

View Article
December 2018

Adverse pregnancy and neonatal outcomes associated with a systematic review and meta-analysis protocol.

BMJ Open 2018 Nov 28;8(11):e024175. Epub 2018 Nov 28.

Public Health Interventions Research Group, Kirby Institute, University of New South Wales, Sydney, New South Wales, Australia.

Introduction: Several bacterial sexually transmitted and genital mycoplasma infections during pregnancy have been associated with poor pregnancy and perinatal outcomes. Comprehensive and systematic information about associations between sexually transmitted infections (STI) and genital infections in pregnancy and adverse perinatal outcomes is needed to improve understanding about the evidence for causal associations between these infections and adverse pregnancy and neonatal outcomes. Our primary objective is to systematically review the literature about associations between: (1) in pregnancy and preterm birth; (2) in pregnancy and preterm birth; (3) and/or in pregnancy and preterm birth. Read More

View Article
November 2018
1 Read

Corrigendum to 'Multilocus sequence typing of Mycoplasma bovis reveals host-specific genotypes in cattle versus bison' Vet. Microbiol. 175 (1) (2015) 92-98.

Vet Microbiol 2018 Nov 26. Epub 2018 Nov 26.

Department of Veterinary Microbiology and Preventive Medicine, College of Veterinary Medicine, Iowa State University, Ames, IA 50011, United States.

View Article
November 2018

Macrolide-resistant Mycoplasma genitalium infections in Cuban patients: an underestimated health problem.

BMC Infect Dis 2018 Nov 29;18(1):601. Epub 2018 Nov 29.

Statens Serum Institut, Research Unit for Reproductive Tract Microbiology, Artillerivej 5, DK-2300, Copenhagen S, Denmark.

Background: The increasing prevalence of macrolide resistant Mycoplasma genitalium is a major concern worldwide. In Cuba, several cases of clinical treatment failure with 1 g single dose and extended azithromycin regimen have been detected and the aim of the present investigation was to retrospectively determine the prevalence of macrolide-resistance mediating mutations (MRMM) in M. genitalium-positive samples conserved at the Cuban National Reference Laboratory of Mycoplasma Research between 2009 and 2016. Read More

View Article
November 2018

Phylogenomics of Endogonaceae and evolution of mycorrhizas within Mucoromycota.

New Phytol 2018 Nov 28. Epub 2018 Nov 28.

Department of Botany and Plant Pathology, Oregon State University, Corvallis, OR, 97331, USA.

Endogonales (Mucoromycotina), composed of Endogonaceae and Densosporaceae, is the only known non-Dikarya order with ectomycorrhizal members. They also form mycorrhizal-like association with some non-Spermatophyte plants. It has been recently proposed that Endogonales were among the earliest mycorrhizal partners with land plants. Read More

View Article
November 2018

Mycoplasmas are no exception to extracellular vesicles release: Revisiting old concepts.

PLoS One 2018 28;13(11):e0208160. Epub 2018 Nov 28.

Université de Lyon, Anses, Laboratoire de Lyon, UMR Mycoplasmoses des Ruminants, Lyon, France.

Release of extracellular vesicles (EV) by Gram-negative and positive bacteria is being frequently reported. EV are nano-sized, membrane-derived, non-self-replicating, spherical structures shed into the extracellular environment that could play a role in bacteria-host interactions. Evidence of EV production in bacteria belonging to the class Mollicutes, which are wall-less, is mainly restricted to the genus Acholeplasma and is scanty for the Mycoplasma genus that comprises major human and animal pathogens. Read More

View Article
November 2018

Prevalence and Clinical Features of Community-Acquired Pneumonia Caused by Macrolide-Resistant Mycoplasma pneumoniae Isolated from Adults in Jeju Island.

Microb Drug Resist 2018 Nov 28. Epub 2018 Nov 28.

2 Department of Internal Medicine, Jeju National University Hospital, Jeju National University School of Medicine , Jeju, Republic of Korea.

Aims: Although the cases of macrolide-resistant Mycoplasma pneumoniae (MRMP) have been increasing substantially among children, there are very few studies that have focused on MRMP in adults. This study aimed to investigate the prevalence and clinical features of community-acquired pneumonia (CAP) caused by MRMP from adults in Jeju Island, Korea.

Methods: We retrospectively recruited adult patients with CAP in whom M. Read More

View Article
November 2018
1 Read

An avian influenza virus H6N1 outbreak in commercial layers: case report and reproduction of the disease.

Avian Pathol 2018 Nov 28:1-35. Epub 2018 Nov 28.

a GD - Animal Health , Arnsbergstraat 7, 7418 EZ , Deventer , the Netherlands.

An outbreak of low pathogenic avian influenza (LPAI) subtype H6N1 (intravenous pathogenicity index = 0.11) infection occurred in four productive brown layer flocks on three farms in the Netherlands within a period of two months. The farms were located at a maximum distance of 4. Read More

View Article
November 2018

Mycoplasma Pneumoniae and Antibodies against Galactocerebroside in a 9-Year-Old Boy with Encephalitis.

Neuropediatrics 2018 Nov 26. Epub 2018 Nov 26.

Department of Pediatric Neurology, Canisius Wilhelmina Hospital, Nijmegen, the Netherlands.

We report the case of a 9 year-old boy, presenting with an acute encephalitis with cerebrospinal fluid pleiocytosis. MRI showed T2/FLAIR (fluid attenuated inversion recovery) hyperintense signals of basal ganglia and cortex, EEG (electro encephalogram) showed diffuse slowing with epileptic discharges. A repetitively elevated IgM/IgG serologic response against was observed with polymerase chain reaction in serum and cerebrospinal fluid remaining negative. Read More

View Article
November 2018
2 Reads

Respiratory pathogens and their association with population performance in Montana and Wyoming bighorn sheep populations.

PLoS One 2018 26;13(11):e0207780. Epub 2018 Nov 26.

Fish and Wildlife Ecology and Management Program, Department of Ecology, Montana State University, Bozeman, Montana, United States of America.

Respiratory disease caused by Mycoplasma ovipneumoniae and Pasteurellaceae poses a formidable challenge for bighorn sheep (Ovis canadensis) conservation. All-age epizootics can cause 10-90% mortality and are typically followed by multiple years of enzootic disease in lambs that hinders post-epizootic recovery of populations. The relative frequencies at which these epizootics are caused by the introduction of novel pathogens or expression of historic pathogens that have become resident in the populations is unknown. Read More

View Article
November 2018

Cervico-vaginal secretion cytokine profile: A non-invasive approach to study the endometrial receptivity in IVF cycles.

Am J Reprod Immunol 2018 Nov 26:e13064. Epub 2018 Nov 26.

Institute for Maternal and Child Health, IRCCS "Burlo Garofolo", Trieste, Italy.

Problem: Cytokines have a significant role in the process of embryo implantation, trophoblast growth, and differentiation by modulating the immune and endocrine system. The aim of this study was to investigate the profile of a large set of cytokines in the cervico-vaginal washing of women undergoing IVF, to explore the association of these proteins with a good receptive endometrium.

Method Of Study: A cohort of 155 women scheduled for IVF cycle was recruited. Read More

View Article
November 2018
7 Reads

The prevalence of bacteriospermia in infertile men and association with semen quality in Southwestern Iran.

Infect Disord Drug Targets 2018 Nov 23. Epub 2018 Nov 23.

Department of Bacteriology and Virology, School of Medicine, Shiraz University of Medical Sciences, Shiraz. Iran.

Introduction: Infertility considered as a social and public health issue and estimated that the most of these infertile couple are residents of developing countries. Infectious diseases including the history of sexually transmitted infections (STIs) may impact on male reproductive function. Therefore, the present study aimed to investigate the prevalence of bacterial contaminants of semen and probable association with sperm quality of infertile men in Iranian population. Read More

View Article
November 2018
3 Reads

Improved Detection of Culprit Pathogens by Bacterial DNA Sequencing Affects Antibiotic Management Decisions in Severe Pneumonia.

Am J Case Rep 2018 Nov 26;19:1405-1409. Epub 2018 Nov 26.

Division of Pulmonary, Allergy and Critical Care Medicine, Department of Medicine, University of Pittsburgh, School of Medicine, Pittsburgh, PA, USA.

BACKGROUND Severe pneumonia requiring admission to an intensive care unit carries high morbidity and mortality. Evidence-based management includes early administration of empiric antibiotics against plausible bacterial pathogens while awaiting results of microbiologic cultures. However, in over 60% of pneumonia cases, no causative pathogen is identified with conventional diagnostic techniques. Read More

View Article
November 2018
2 Reads

Effect of temperature on the microflora community composition in the digestive tract of the veined rapa whelk (Rapana venosa) revealed by 16S rRNA gene sequencing.

Comp Biochem Physiol Part D Genomics Proteomics 2018 Oct 23;29:145-153. Epub 2018 Oct 23.

CAS Key Laboratory of Marine Ecology and Environmental Sciences, Institute of Oceanology, Chinese Academy of Sciences, Qingdao 266071, China; Laboratory for Marine Ecology and Environmental Science, Qingdao National Laboratory for Marine Science and Technology, Qingdao 266237, China; Center for Ocean Mega-Science, Chinese Academy of Sciences, Qingdao 266071, China. Electronic address:

The veined rapa whelk, Rapana venosa, a poikilotherm that is susceptible to temperature, is an important and valuable fishery resource in China but a major invader around the world. We studied the effects of abnormal temperature on the digestive tract microflora of R. venosa to investigate how temperature impacts its digestion and ingestion. Read More

View Article
October 2018

A versatile loop-mediated isothermal amplification microchip platform for Streptococcus pneumoniae and Mycoplasma pneumoniae testing at the point of care.

Biosens Bioelectron 2018 Nov 12;126:373-380. Epub 2018 Nov 12.

Department of Laboratory Medicine, Renji Hospital, School of Medicine, Shanghai Jiaotong University, Shanghai, China. Electronic address:

Community-acquired pneumonia (CAP) is the leading cause of mortality in children under five years of age, globally. Given that Streptococcus pneumoniae (S. pneumoniae) and Mycoplasma pneumoniae (M. Read More

View Article
November 2018
1 Read
6.409 Impact Factor

Screening for Mollicutes microorganisms in perinatal calf mortality cases in Polish dairy herds.

Pol J Vet Sci 2018 Sep;21(3):441-444

Department of Immunology, Pathophysiology and Veterinary Preventive Medicine, Wroclaw University of Environmental and Life Sciences, C.K. Norwida 31 str., 50-375 Wroclaw, Poland.

Perinatal calf mortality in dairy herds has been reported worldwide. The etiology of stillbirth is multifactorial, and can be caused by various species of bacteria and environmental factors. Among them some potential pathogens from the Mollicutes class such as Mycoplasma (M. Read More

View Article
September 2018
1 Read

Arginine-Depleting Enzymes - An Increasingly Recognized Treatment Strategy for Therapy-Refractory Malignancies.

Cell Physiol Biochem 2018 22;51(2):854-870. Epub 2018 Nov 22.

Department of Medicine, Clinic III-Hematology/ Oncology/Palliative Care, Rostock University Medical Center, University of Rostock, Rostock,

Arginine auxotrophy occurs in certain tumor types and is usually caused by the silencing of argininosuccinate synthetase 1 or arginine lyase genes. Such tumors are often associated with an intrinsic chemoresistance and thus a poor prognosis. Arginine auxotrophy however renders these tumors vulnerable to treatment with arginine-degrading enzymes. Read More

View Article
November 2018
1 Read

Feline upper respiratory tract infection and disease in Australia.

J Feline Med Surg 2018 Nov 22:1098612X18813248. Epub 2018 Nov 22.

1 Sydney School of Veterinary Science, The University of Sydney, Camden, Australia.

Objectives: The aim of this study was to conduct a comprehensive assessment of feline infectious upper respiratory tract infection (URTI) and disease (URTD) in Australian cats.

Methods: Laboratory data demonstrating URTI from feline URTD multiplex PCR panel (feline Herpesvirus 1 [FHV-1], feline calicivirus [FCV], Bordetella bronchiseptica, Chlamydophila felis, Mycoplasma felis and H1N1 influenza) submissions in Australia (2013-2015) were obtained. For comparison, reports of feline URTD during the same time period were sourced from a voluntary companion animal disease surveillance system. Read More

View Article
November 2018
1 Read

Designing of an epitope-based peptide vaccine against walking pneumonia: an immunoinformatics approach.

Mol Biol Rep 2018 Nov 21. Epub 2018 Nov 21.

Department of Biotechnology, School of Bio Sciences and Technology, VIT University, Vellore, Tamil Nadu, 632014, India.

Mycoplasma pneumoniae is a substantial respiratory pathogen that develops not only pneumonia but also other respiratory diseases, which mimic viral respiratory syndromes. Nevertheless, vaccine development for this pathogen delays behind as immunity correlated with protection is now predominantly unknown. In the present study, an immunoinformatics pipeline is utilized for epitope-based peptide vaccine design, which can trigger a critical immune response against M. Read More

View Article
November 2018
2 Reads

Clinical features and seasonal variations in the prevalence of macrolide-resistant .

J Gen Fam Med 2018 Nov 23;19(6):191-197. Epub 2018 Aug 23.

Department of Pediatrics Tsukuba Medical Center Hospital Tsukuba Ibaraki Japan.

Background: is a common pathogen causing pneumonia; macrolide-resistant strains are rapidly spreading across Japan. However, the clinical features of macrolide-resistant pneumonia have not been well established. Here, we evaluated the clinical characteristics and seasonal variations in the prevalence of with macrolide-resistant mutations (MRM). Read More

View Article
November 2018
2 Reads

Hemotropic mycoplasmas in naturally infected cats in Northeastern Brazil.

Rev Bras Parasitol Vet 2018 Oct-Dec;27(4):446-454. Epub 2018 Nov 14.

Departamento de Patologia Animal, Universidade Estadual Júlio de Mesquita Filho - UNESP, Jaboticabal, SP, Brasil.

This study aimed to determine the prevalence, factors associated, laboratory findings (with and without coinfection by retroviruses) among naturally infected cats by hemoplasmas in northeastern Brazil. For convenience, 200 domesticated and healthy cats were selected. Blood samples were taken to perform complete blood counts, serum biochemical, immunochromatography tests and nPCR for FIV and FeLV, and PCR for hemoplasma recognition. Read More

View Article
November 2018
1 Read

Application of different laboratory techniques to monitor the behaviour of a Mycoplasma synoviae vaccine (MS-H) in broiler breeders.

BMC Vet Res 2018 Nov 20;14(1):357. Epub 2018 Nov 20.

Avian Medicine Laboratory Mycoplasma Unit - SCT1, Istituto Zooprofilattico Sperimentale delle Venezie, Viale dell'Università 10, 35020. Legnaro, Padova, Italy.

Background: Mycoplasma synoviae (MS) is a major poultry pathogen which causes severe economic losses in all the productive sectors. The prevalence of MS in European countries has increased in the last few years, leading to greater attention to the available methods to prevent its spread. The main strategy currently applied for its containment is the development and maintenance of MS-free breeder flocks. Read More

View Article
November 2018

Mycoplasma ovipneumoniae in Wildlife Species beyond Subfamily Caprinae.

Emerg Infect Dis 2018 Dec;24(12):2384-2386

Elucidating the emergence of Mycoplasma ovipneumoniae-associated respiratory disease in ruminants requires identification of the pathogen host range. This bacterium was thought to be host restricted to subfamily Caprinae, but we describe its identification in healthy moose, caribou, and mule deer and diseased mule and white-tailed deer, all species in subfamily Capreolinae. Read More

View Article
December 2018
7 Reads

Disseminated Spiroplasma apis Infection in Patient with Agammaglobulinemia, France.

Emerg Infect Dis 2018 Dec;24(12):2382-2386

We report a disseminated infection caused by Spiroplasma apis, a honeybee pathogen, in a patient in France who had X-linked agammaglobulinemia. Identification was challenging because initial bacterial cultures and direct examination by Gram staining were negative. Unexplained sepsis in patients with agammaglobulinemia warrants specific investigation to identify fastidious bacteria such as Spiroplasma spp. Read More

View Article
December 2018

Loss of protein synthesis quality control in host-restricted organisms.

Proc Natl Acad Sci U S A 2018 Dec 19;115(49):E11505-E11512. Epub 2018 Nov 19.

Department of Molecular Biophysics and Biochemistry, Yale University, New Haven, CT 06511;

Intracellular organisms, such as obligate parasites and endosymbionts, typically possess small genomes due to continuous genome decay caused by an environment with alleviated natural selection. Previously, a few species with highly reduced genomes, including the intracellular pathogens and , have been shown to carry degenerated editing domains in aminoacyl-tRNA synthetases. These defects in the protein synthesis machinery cause inaccurate translation of the genetic code, resulting in significant statistical errors in protein sequences that are thought to help parasites to escape immune response of a host. Read More

View Article
December 2018
1 Read

Organization of multi-binding to host proteins: The glyceraldehyde-3-phosphate dehydrogenase (GAPDH) of Mycoplasma pneumoniae.

Microbiol Res 2019 Jan 26;218:22-31. Epub 2018 Sep 26.

Technische Universität Dresden, Medizinische Fakultät Carl Gustav Carus, Institut für Medizinische Mikrobiologie und Hygiene, Fetscherstrasse 74, 01307, Dresden, Germany. Electronic address:

Mycoplasma pneumoniae is a frequent cause of community-acquired infections of the human respiratory tract. During the evolutionary adaptation of the bacteria to the host, the genome of the pathogen is strongly reduced resulting in the loss of cell wall, limited metabolic pathways and a relatively small number of virulence factors. As interacting with host proteins, surface-exposed proteins with a primary function in cytosol-located processes of metabolism and regulation such as glycolytic enzymes, heat-shock proteins and chaperones have been considered as contributing to pathogenesis. Read More

View Article
January 2019
7 Reads

Fructose-1,6-bisphosphate aldolase encoded by a core gene of Mycoplasma hyopneumoniae contributes to host cell adhesion.

Vet Res 2018 Nov 19;49(1):114. Epub 2018 Nov 19.

Key Laboratory of Veterinary Biological Engineering and Technology of Ministry of Agriculture, Institute of Veterinary Medicine, Jiangsu Academy of Agricultural Sciences, Nanjing, China.

Mycoplasma hyopneumoniae is an important respiratory pathogen that causes great economic losses to the pig industry worldwide. Although some putative virulence factors have been reported, pathogenesis remains poorly understood. Herein, we evaluated the relative abundance of proteins in virulent 168 (F107) and attenuated 168L (F380) M. Read More

View Article
November 2018
2 Reads

Gallbladder agenesis with hepatic impairment: a case report.

BMC Pediatr 2018 Nov 19;18(1):360. Epub 2018 Nov 19.

Department of Pediatrics, Sakai City Medical Center, 1-1-1 Ebaraji-Cho, Nishi-Ku, Sakai City, Osaka, 593-8304, Japan.

Background: Gallbladder agenesis is a rare congenital malformation. More than 50% of cases are isolated and asymptomatic. These asymptomatic patients are principally healthy and need no interventions. Read More

View Article
November 2018
3 Reads

Hemotrophic mycoplasma in Simmental cattle in Bavaria: prevalence, blood parameters, and transplacental transmission of 'Candidatus Mycoplasma haemobos' and Mycoplasma wenyonii.

Acta Vet Scand 2018 Nov 16;60(1):74. Epub 2018 Nov 16.

Tiergesundheitsdienst Bayern e.V., Senator-Gerauer-Str. 23, 85586, Poing, Germany.

Background: The significance of hemotrophic mycoplasma in cattle remains unclear. Especially in Europe, their epidemiological parameters as well as pathophysiological influence on cows are lacking. The objectives of this study were: (1) to describe the prevalence of 'Candidatus Mycoplasma haemobos' ('C. Read More

View Article
November 2018
1 Read

A multiplex xTAG assay for the simultaneous detection of five chicken immunosuppressive viruses.

BMC Vet Res 2018 Nov 15;14(1):347. Epub 2018 Nov 15.

Guangdong Laboratory Animals Monitoring Institute and Guangdong Provincial Key Laboratory of Laboratory Animals, Guangzhou, 510633, China.

Background: Chicken anemia virus (CAV), avian reovirus (ARV), infectious bursal disease virus (IBDV), Marek's disease virus (MDV) and reticuloendotheliosis virus (REV) all cause immunosuppressive disease in birds through vertical or horizontal transmission. Mixed infections with these immunosuppressive pathogens lead to atypical clinical signs and obstruct accurate diagnoses and epidemiological investigations. Therefore, it is essential to develop a high-throughput assay for the simultaneous detection of these immunosuppressive viruses with high specificity and sensitivity. Read More

View Article
November 2018
3 Reads

ABSTRACT.

Acta Clin Belg 2018 Nov;73(sup1):1-9

a Belgian Reference Centre for Respiratory Pathogens , University Hospital Antwerp , Belgium.

View Article
November 2018
1 Read

Metal-free ribonucleotide reduction powered by a DOPA radical in Mycoplasma pathogens.

Nature 2018 Nov 31;563(7731):416-420. Epub 2018 Oct 31.

Department of Biochemistry and Biophysics, Stockholm University, Arrhenius Laboratories for Natural Sciences, Stockholm, Sweden.

Ribonucleotide reductase (RNR) catalyses the only known de novo pathway for the production of all four deoxyribonucleotides that are required for DNA synthesis. It is essential for all organisms that use DNA as their genetic material and is a current drug target. Since the discovery that iron is required for function in the aerobic, class I RNR found in all eukaryotes and many bacteria, a dinuclear metal site has been viewed as necessary to generate and stabilize the catalytic radical that is essential for RNR activity. Read More

View Article
November 2018
11 Reads
42.350 Impact Factor

Scopulariopsis brevicaulis Rhinosinal Infection in a Dog.

J Am Anim Hosp Assoc 2018 Nov 14. Epub 2018 Nov 14.

From the Department of Clinical Sciences (V.S., K.G.M.), College of Veterinary Medicine (L.S-J.), North Carolina State University, Raleigh, North Carolina.

A 1 yr old castrated male American Staffordshire terrier mix was treated for Scopulariopsis brevicaulis that was discovered during an evaluation of chronic rhinosinusitis. A sinusotomy was performed, with intraoperative infusion of amikacin-impregnated gel and systemic administration of postoperative amikacin. Antibiotic therapy was initially chosen because of historic culture of Mycoplasma. Read More

View Article
November 2018
8 Reads

Molecular Distance to Health Transcriptional Score and Disease Severity in Children Hospitalized With Community-Acquired Pneumonia.

Front Cell Infect Microbiol 2018 30;8:382. Epub 2018 Oct 30.

Division of Infectious Diseases, Nationwide Children's Hospital, Columbus, OH, United States.

Community-acquired pneumonia (CAP) is a leading cause of hospitalization and mortality in children. Diagnosis remains challenging and there are no reliable tools to objectively risk stratify patients or predict clinical outcomes. Molecular distance to health (MDTH) is a genomic score that measures the global perturbation of the transcriptional profile and may help classify patients by disease severity. Read More

View Article
October 2018
8 Reads

Pneumonia: Walking Pneumonia Can Cripple the Susceptible.

J Clin Med Res 2018 Dec 30;10(12):891-897. Epub 2018 Oct 30.

Division of Pulmonary and Critical Care Medicine, Bronx Care Health System, Bronx, NY 10457, USA.

Background: pneumonia (MPP), or "walking pneumonia," is an atypical mild disease with varied clinical findings. Specifically, diagnosis is often controversial and understanding of disease presentation is limited. The goal of the study was to evaluate presentation, clinical associations and outcomes of MPP patients admitted to an inner-city hospital. Read More

View Article
December 2018
3 Reads

Sialidase and N-acetylneuraminate catabolism in nutrition of Mycoplasma alligatoris.

Microbiology 2018 Nov 13. Epub 2018 Nov 13.

1​Department of Infectious Diseases and Immunology, University of Florida, Gainesville, Florida 32611, USA.

The contribution of N-acetylneuraminate scavenging to the nutrition of Mycoplasma alligatoris was examined. The wild-type grew substantially faster (P<0.01) than the mutant strains that were unable either to liberate (extracellular NanI mutants) or to catabolize (NanA mutants) N-acetylneuraminate from glycoconjugates in minimal SP-4 medium supplemented only with serum, but the growth of sialidase-negative mutants could not be restored to wild-type rate simply by adding unconjugated sialic acid to the culture medium. Read More

View Article
November 2018
8 Reads

The demographic and clinical profiles of women presenting with vaginal discharge syndrome at primary care facilities in South Africa: Associations with age and implications for management.

S Afr Med J 2018 Oct 2;108(10):876-880. Epub 2018 Oct 2.

Centre for HIV and STIs, National Institute for Communicable Diseases, Johannesburg, South Africa; School of Public Health, Faculty of Health Sciences, University of the Witwatersrand, Johannesburg, South Africa.

Background: Current South African guidelines for the management of vaginal discharge syndrome (VDS) do not recommend treatment for sexually transmitted infection (STI) pathogens for women aged ≥35 years whose partners do not have male urethritis syndrome. The guideline assumes that older women are unlikely to have an STI and that their partners do not have asymptomatic infections.

Objectives: To describe the demographic, behavioural and clinical characteristics of women with VDS, comparing older women (≥35 years) with younger women, and to determine the performance of age alone as a criterion for predicting the presence of STI. Read More

View Article
October 2018
1 Read

A Fulminant Case of Acute Respiratory Distress Syndrome Associated with Mycoplasma Pneumonia Treated with Nasal High-Flow Oxygen Therapy.

Case Rep Crit Care 2018 21;2018:1067593. Epub 2018 Oct 21.

Department of Pulmonary Medicine, Eiju General Hospital, 2-23-16 Higashiueno, Taito-ku, Tokyo 110-8645, Japan.

Introduction: The prognosis of mycoplasma pneumonia in adults is generally favorable, but a few patients show progression to acute respiratory distress syndrome (ARDS). We have described the management of a patient who showed progression of mycoplasma pneumonia to ARDS.

Presentation Of Case: A 26-year-old male patient with no significant past medical or social history presented with a 5-day history of fever. Read More

View Article
October 2018
2 Reads

Bacterial superantigens expand and activate, rather than delete or incapacitate, preexisting antigen-specific memory CD8+ T cells.

J Infect Dis 2018 Nov 12. Epub 2018 Nov 12.

Department of Microbiology and Immunology, Western University, London, Ontario, Canada.

Superantigens (SAgs) released by common Gram-positive bacterial pathogens have been reported to delete, anergize or activate mouse T cells. However, little is known about their effects on preexisting memory CD8 + T cell (TCD8) pools. Furthermore, whether SAgs manipulate human memory TCD8 responses to cognate antigens is unknown. Read More

View Article
November 2018

Outbreak of Mycoplasmal Round Pneumonia in an Adult Population: a Case Series.

Clin Respir J 2018 Nov 12. Epub 2018 Nov 12.

Department of Respiratory and Critical Care Medicine, Fuzhou General Hospital of the PLA, Fuzhou General Hospital of Fujian Medical University, Dongfang Hospital of Xiamen University.

Background: Mycoplasmal pneumonia is a common type of adult community-acquired pneumonia in China, but round/spherical pneumonia caused by mycoplasma pneumoniae has rarely been reported. Here we report an outbreak of mycoplasmal round pneumonia in a military dormitory in China.

Methods: We analysed epidemiological, clinical, imaging and laboratory data from a series of adults affected by an outbreak of mycoplasmal round pneumonia in the dormitory of a military hospital (Fuzhou General Hospital) in Fuzhou, China. Read More

View Article
November 2018
3 Reads

Low Bacterial Co-infection Invalidates the Early Use of Non-anti- Antibiotics in Pediatric Refractory Pneumonia Patients.

Front Pediatr 2018 26;6:296. Epub 2018 Oct 26.

Department 2 of Respiratory Medicine, National Center for Children's Health, Beijing Children's Hospital, Capital Medical University, Beijing, China.

Childhood refractory mycoplasma pneumoniae (MP) pneumonia (RMPP) is a lung disease with elevated level of C-reactive protein and severe clinical and radiological deterioration. Whether bacterial co-infection contributes to disease of RMPP and whether inclusion of non-anti-MP antibiotics in treatment regimen would benefit RMPP patients remains elusive. We retrospectively reviewed the medical records of 675 RMPP children. Read More

View Article
October 2018
5 Reads