16,023 results match your criteria Mycoplasma Infections


in Spanish Cattle Herds: Two Groups of Multiresistant Isolates Predominate, with One Remaining Susceptible to Fluoroquinolones.

Pathogens 2020 Jul 7;9(7). Epub 2020 Jul 7.

Ruminant Health Research Group, Department of Animal Health, Faculty of Veterinary Sciences, Regional Campus of International Excellence "Campus Mare Nostrum", University of Murcia, 30100 Murcia, Spain.

is an important bovine pathogen causing pneumonia, mastitis, and arthritis and is responsible for major economic losses worldwide. In the absence of an efficient vaccine, control of infections mainly relies on antimicrobial treatments, but resistance is reported in an increasing number of countries. To address the situation in Spain, was searched in 436 samples collected from beef and dairy cattle (2016-2019) and 28% were positive. Read More

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http://dx.doi.org/10.3390/pathogens9070545DOI Listing

Antimicrobial resistance, genetic characterization, and molecular epidemiology of Ureaplasma species in males with infertility.

Eur J Clin Microbiol Infect Dis 2020 Jul 8. Epub 2020 Jul 8.

Department of Laboratory, Tai'an Central Hospital, Tai'an, 271000, China.

This study aimed to study the antimicrobial resistance, genetic characterization, and molecular epidemiology of Ureaplasma species in order to provide clinicians sufficient data to select optimal strategies of treatment for genitourinary tract infections of infertile male patients. Firstly, a total of 817 clinical semen specimens were detected for Ureaplasma species by molecular detection. Secondly, culture and identification of Ureaplasma species were achieved by using Mycoplasma ICS Test, and the antimicrobial susceptibility tests were determined by using broth microdilution assay. Read More

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http://dx.doi.org/10.1007/s10096-020-03969-7DOI Listing

Genetic characterization and risk factors for feline hemoplasma infection in semi-domesticated cats in Bangkok, Thailand.

Vet World 2020 May 23;13(5):975-980. Epub 2020 May 23.

Department of Parasitology, Faculty of Veterinary Medicine, Kasetsart University, Bangkok, Thailand.

Background And Aim: Stray cats are a reservoir for various zoonotic diseases relevant to public health in Thailand. The vector-borne infection, hemoplasmosis, also known as infectious anemia, is one such disease carried by domestic and wild felids. This study focuses on molecular characterization and phylogenetic analysis of hemoplasma in semi-domesticated cats in Bangkok, Thailand. Read More

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http://dx.doi.org/10.14202/vetworld.2020.975-980DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7311864PMC

Prevalence of mutations associated with resistance to macrolides and fluoroquinolones in Mycoplasma genitalium: a systematic review and meta-analysis.

Lancet Infect Dis 2020 Jul 2. Epub 2020 Jul 2.

Centre for Epidemiology and Biostatistics, Melbourne School of Population and Global Health, University of Melbourne, Parkville, VIC, Australia; Melbourne Sexual Health Centre, Alfred Health, Melbourne, VIC, Australia; Central Clinical School, Monash University, Melbourne, VIC, Australia.

Background: Mycoplasma genitalium is now recognised as an important bacterial sexually transmitted infection. We summarised data from studies of mutations associated with macrolide and fluoroquinolone resistance in M genitalium to establish the prevalence of resistance. We also investigated temporal trends in resistance and aimed to establish the association between resistance and geographical location. Read More

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http://dx.doi.org/10.1016/S1473-3099(20)30154-7DOI Listing

The curative effects of shortwave diathermy on treating Novel coronavirus (COVID-19) pneumonia: A structured summary of a study protocol for a randomised controlled trial.

Trials 2020 Jul 3;21(1):609. Epub 2020 Jul 3.

Department of Rehabilitation Medicine, Tongji Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, 430030, People's Republic of China.

Objectives: To evaluate the therapeutic effects of ultra-short-wave diathermy (SWD) on COVID-19 pneumonia. The hypothesis is that SWD may minimise pneumonic inflammation and shorten the duration of the time to positive-to-negative conversion of COVID-19 nucleic acid test.

Trial Design: This is a single centre, 2-arm (1:1 ratio), evaluator blinded, parallel group design superiority randomised, controlled clinical trial. Read More

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http://dx.doi.org/10.1186/s13063-020-04534-5DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7332534PMC
July 2020
2.117 Impact Factor

Nodular distribution pattern on chest computed tomography (CT) in patients diagnosed with nontuberculous mycobacteria (NTM) infections.

Wien Klin Wochenschr 2020 Jul 2. Epub 2020 Jul 2.

Emergency Department of Zagreb County, Matice Hrvatske, Zagreb, Croatia.

Background: This study evaluated the prevalence of spreading pathways in nontuberculous mycobacteria (NTM) pulmonary infections according to nodular distribution patterns seen on chest computed tomography (CT).

Methods: This study included 63 patients diagnosed with NTM lung infections who underwent CT at our institution. A retrospective analysis of CT images focused on the presence and distribution of nodules, presence of intrathoracic lymphadenopathy and the predominant side of infection in the lungs. Read More

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http://dx.doi.org/10.1007/s00508-020-01701-1DOI Listing

COVID-19 in two infants in China.

Immun Inflamm Dis 2020 Jul 2. Epub 2020 Jul 2.

Yichang Central People's Hospital, The First College of Clinical Medical Science, China Three Gorges University, Yichang, China.

Introduction: Since December 2019, severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) has spread rapidly around the world and caused more than 487 000 infections and 22 000 deaths worldwide.

Methods: We report two infant cases with coronavirus disease 2019 (COVID-19) in Yichang, Hubei, China. The younger of the two is only 5-months old. Read More

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http://dx.doi.org/10.1002/iid3.319DOI Listing

Prevalence of and antibiotic resistance-associated mutations in an Icelandic STI population, and comparison of the S-DiaMGTV and Aptima assays for diagnosis.

J Clin Microbiol 2020 Jul 1. Epub 2020 Jul 1.

Department of Microbiology, Landspítali - The University Hospital of Iceland, Reykjavík, Iceland.

(MG) is prevalent among attendees in sexually transmitted infections (STI) clinics and therapy is hampered by rapidly rising levels of resistance to azithromycin and moxifloxacin. In this study we evaluated, for the first time in Iceland, the prevalence of MG and azithromycin and moxifloxacin resistance-associated mutations, and assessed the diagnostic performance of the CE/IVD-marked S-DiaMGTV (Diagenode Diagnostics) versus the US FDA/CE/IVD-approved Aptima MG (AMG; Hologic) for MG detection. From October 2018 to January 2019, urine and vaginal swabs were provided by male and female attendees at Iceland's only STI clinic. Read More

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http://dx.doi.org/10.1128/JCM.01084-20DOI Listing

Complex interactions between bacteria and haemosporidia in coinfected hosts: An experiment.

Ecol Evol 2020 Jun 29;10(12):5801-5814. Epub 2020 Apr 29.

Laboratory of Ornithology Cornell University Ithaca New York.

Hosts are typically coinfected by multiple parasite species whose interactions might be synergetic or antagonistic, producing unpredictable physiological and pathological impacts on the host. This study shows the interaction between spp. and spp. Read More

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http://dx.doi.org/10.1002/ece3.6318DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7319152PMC

Host Epigenetics in Intracellular Pathogen Infections.

Int J Mol Sci 2020 Jun 27;21(13). Epub 2020 Jun 27.

Division of Cellular Immunology, Department of Immunology and Infectious Biology, Faculty of Biology and Environmental Protection, University of Lodz, 90-237 Lodz, Poland.

Some intracellular pathogens are able to avoid the defense mechanisms contributing to host epigenetic modifications. These changes trigger alterations tothe chromatin structure and on the transcriptional level of genes involved in the pathogenesis of many bacterial diseases. In this way, pathogens manipulate the host cell for their own survival. Read More

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http://dx.doi.org/10.3390/ijms21134573DOI Listing

Mycoplasma hominis bursitis in a simultaneous pancreas-kidney transplant recipient; case report and literature review.

Transpl Infect Dis 2020 Jun 30:e13392. Epub 2020 Jun 30.

College of Medicine and Public Health, Flinders University, Adelaide, South Australia, Australia.

Mycoplasma hominis can be isolated frequently from the genitourinary tract of some healthy individuals. On rare occasions, it acts as a pathogen in immunocompromised patients such as transplant recipients. Here we describe the case of a 39 year-old-man with end stage kidney disease secondary to diabetic nephropathy who received a simultaneous kidney-pancreas transplant. Read More

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http://dx.doi.org/10.1111/tid.13392DOI Listing

Epidemiology of genital infections caused by Mycoplasma hominis, M. genitalium and Ureaplasma urealyticum in Iran; a systematic review and meta-analysis study (2000-2019).

BMC Public Health 2020 Jun 29;20(1):1020. Epub 2020 Jun 29.

Department of Microbiology and Virology, Faculty of Medicine, Mashhad University of Medical Sciences, Mashhad, Iran.

Background: Although many species of mycoplasmas regard as normal flora, but some species causes serious genital disease. In Iran several epidemiological studies have documented the prevalence of Mycoplasma hominis, M. genitalium and Ureaplasma urealyticum in genital disorders. Read More

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http://dx.doi.org/10.1186/s12889-020-08962-5DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7322857PMC

Mycoplasma pneumoniae-associated Stevens-Johnson syndrome: Characteristic histological features of mucosal lesion.

J Eur Acad Dermatol Venereol 2020 Jun 28. Epub 2020 Jun 28.

Division of Dermatology, Niigata University, Graduate School of Medicine and Dental Sciences.

Mycoplasma pneumoniae induces various skin conditions, potentially characterized by the development of extensive mucosal/eye lesions consistent with Stevens-Johnson syndrome (SJS). Particularly, in cases of pediatric SJS, M. pneumoniae infections are a major etiology. Read More

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http://dx.doi.org/10.1111/jdv.16796DOI Listing

Gasdermin D-independent release of interleukin-1b by living macrophages in response to mycoplasmal lipoproteins and lipopeptides.

Immunology 2020 Jun 26. Epub 2020 Jun 26.

Department of Oral Molecular Microbiology, Faculty of Dental Medicine and Graduate School of Dental Medicine, Hokkaido University, Nishi 7, Kita 13, Kita-ku, Sapporo, Japan.

Interleukin-1b (IL-1b) plays pivotal roles in controlling bacterial infections and is produced after the processing of pro-IL-1b by caspase-1 which is activated by the inflammasome. In addition, caspase-1 cleaves the cytosolic protein, gasdermin-D (GSDMD), whose N-terminal fragment subsequently forms a pore in the plasma membrane, leading to the pyroptic cell death-mediated release of IL-1b. Living cells can also release IL-1b via GSDMD pores or other unconventional secretory pathways. Read More

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http://dx.doi.org/10.1111/imm.13230DOI Listing

Epidemiological and Clinical Characteristics of Patients With Coronavirus Disease-2019 in Shiyan City, China.

Front Cell Infect Microbiol 2020 22;10:284. Epub 2020 May 22.

Department of Infectious Diseases, Department of Respiratory, Renmin Hospital, School of Basic Medical Sciences, Hubei University of Medicine, Shiyan, China.

To investigate the early epidemic of COVID-19, a total of 176 confirmed COVID-19 cases in Shiyan city, Hubei province, China were surveyed. Our data indicated that the rate of emergence of early confirmed COVID-19 cases in Hubei province outside Wuhan was dependent on migration population, and the second-generation of patients were family clusters originating from Wuhan travelers. Epidemiological investigation indicated that the reproductive number (R) under containment strategies was 1. Read More

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http://dx.doi.org/10.3389/fcimb.2020.00284DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7256435PMC
June 2020
2.620 Impact Factor

[Clinical features of asymptomatic or subclinical COVID-19 in children].

Zhongguo Dang Dai Er Ke Za Zhi 2020 Jun;22(6):578-582

Department of Respiratory Medicine, Wuhan Children's Hospital/Wuhan Maternal and Child Healthcare Hospital, Tongji Medical College, Huazhong University of Science & Technology, Wuhan 430016, China.

Objective: To study the clinical features of asymptomatic or subclinical coronavirus disease 2019 (COVID-19) in children.

Methods: A retrospective analysis was performed for the clinical data of 53 children who were confirmed with asymptomatic or subclinical COVID-19, including epidemiological history, clinical typing, co-infection, time to clearance of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) nucleic acid in nasopharyngeal swabs, laboratory examination results, length of hospital stay, and treatment outcome.

Results: The children with asymptomatic or subclinical COVID-19 accounted for 30. Read More

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Optimising treatments for sexually transmitted infections: surveillance, pharmacokinetics and pharmacodynamics, therapeutic strategies, and molecular resistance prediction.

Lancet Infect Dis 2020 Jun 19. Epub 2020 Jun 19.

WHO Collaborating Centre for Gonorrhoea and Other Sexually Transmitted Infections and the Swedish Reference Laboratory for STIs, Department of Laboratory Medicine, Faculty of Medicine and Health, Örebro University, Örebro, Sweden.

Progressive antimicrobial resistance in Neisseria gonorrhoeae, Mycoplasma genitalium, and Trichomonas vaginalis has created a pressing need for treatment optimisations for sexually transmitted infections (STIs). In this Review, we aim to highlight urgent needs in global STI management, including: (1) improved surveillance to monitor antimicrobial resistance and clinical outcomes; (2) systematic pharmacokinetic and pharmacodynamic evaluations to ensure resistance suppression and bacterial eradication at all sites of infection; (3) development of novel, affordable antimicrobials; and (4) advancements in new molecular and point-of-care tests to detect antimicrobial resistance determinants. Antimicrobial resistance among STIs is a global public health crisis. Read More

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http://dx.doi.org/10.1016/S1473-3099(20)30171-7DOI Listing

CLEARANCE OF MYCOPLASMA GENITALIUM AND TRICHOMONAS VAGINALIS AMONG ADOLESCENTS AND YOUNG ADULTS WITH PELVIC INFLAMMATORY DISEASE: RESULTS FROM THE TECH-N STUDY.

Sex Transm Dis 2020 Jun 18. Epub 2020 Jun 18.

Department of Medicine, Johns Hopkins University School of Medicine, Baltimore, Maryland, USA.

Current PID treatment effectively treats Neisseria gonorrhoeae (NG) and Chlamydia trachomatis (CT). However, coverage may be inadequate for Mycoplasma genitalium (MG)/Trichomonas vaginalis (TV) infections. We compared the longitudinal MG and TV outcomes with NG/CT outcomes for women enrolled in a longitudinal randomized controlled trial to optimize outcomes after PID. Read More

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http://dx.doi.org/10.1097/OLQ.0000000000001221DOI Listing

Macrolide-Resistant Mycoplasma pneumoniae Infections in Pediatric Community-Acquired Pneumonia.

Emerg Infect Dis 2020 Jul;26(7):1382-1391

A high prevalence rate of macrolide-resistant Mycoplasma pneumoniae (MRMP) has been reported in Asia. We performed a systematic review and meta-analysis to investigate the effect of macrolide resistance on the manifestations and clinical judgment during M. pneumoniae infections. Read More

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http://dx.doi.org/10.3201/eid2607.200017DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7323531PMC

Population Prevalence of sexually transmitted infections in a high HIV burden district in KwaZulu-Natal, South Africa: Implications for HIV epidemic control.

Int J Infect Dis 2020 Jun 17. Epub 2020 Jun 17.

Centers for Disease Control and Prevention (CDC), Atlanta, USA.

Background: Sexually transmitted infections (STIs) and Human immunodeficiency virus (HIV) share a complex bidirectional relationship, however, population prevalence and the association between the presence of STIs and HIV in a high HIV burden district in KwaZulu-Natal, South Africa is not known.

Methods: A total of 9812 participants aged 15-49 years were enrolled in a cross-sectional population-based household survey. Participants completed a structured questionnaire and provided first-pass urine (males) or self-collected vulvo-vaginal swabs (females) for the detection of STIs. Read More

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http://dx.doi.org/10.1016/j.ijid.2020.06.046DOI Listing

Antimicrobial treatment of Mycoplasma hyopneumoniae infections.

Vet J 2020 May - Jun;259-260:105474. Epub 2020 May 22.

Mycoplasmology, Bacteriology and Antimicrobial Resistance Unit, Ploufragan-Plouzané-Niort Laboratory, French Agency for Food, Environmental and Occupational Health and Safety (Anses), France.

Mycoplasma hyopneumoniae (M. hyopneumoniae) is the primary agent of enzootic pneumonia, a chronic and economically important respiratory disease of pigs. Control and prevention of M. Read More

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http://dx.doi.org/10.1016/j.tvjl.2020.105474DOI Listing

Coinfections and their molecular consequences in the porcine respiratory tract.

Vet Res 2020 Jun 16;51(1):80. Epub 2020 Jun 16.

INRAE, Oniris, BIOEPAR, 44300, Nantes, France.

Understudied, coinfections are more frequent in pig farms than single infections. In pigs, the term "Porcine Respiratory Disease Complex" (PRDC) is often used to describe coinfections involving viruses such as swine Influenza A Virus (swIAV), Porcine Reproductive and Respiratory Syndrome Virus (PRRSV), and Porcine CircoVirus type 2 (PCV2) as well as bacteria like Actinobacillus pleuropneumoniae, Mycoplasma hyopneumoniae and Bordetella bronchiseptica. The clinical outcome of the various coinfection or superinfection situations is usually assessed in the studies while in most of cases there is no clear elucidation of the fine mechanisms shaping the complex interactions occurring between microorganisms. Read More

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http://dx.doi.org/10.1186/s13567-020-00807-8DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7296899PMC

Sensitivity, specificity, inclusivity and exclusivity of the updated Aptima Combo 2 assay, which provides detection coverage of the new diagnostic-escape Chlamydia trachomatis variants.

BMC Infect Dis 2020 Jun 16;20(1):419. Epub 2020 Jun 16.

World Health Organization Collaborating Centre for Gonorrhoea and Other Sexually Transmitted Infections (STIs), National Reference Laboratory for STIs, Department of Laboratory Medicine, Clinical Microbiology, Faculty of Medicine and Health, Örebro University, SE-701 85, Örebro, Sweden.

Background: Four new variants of Chlamydia trachomatis (nvCTs), detected in several countries, cause false-negative or equivocal results using the Aptima Combo 2 assay (AC2; Hologic). We evaluated the clinical sensitivity and specificity, as well as the analytical inclusivity and exclusivity of the updated AC2 for the detection of CT and Neisseria gonorrhoeae (NG) on the automated Panther system (Hologic).

Methods: We examined 1004 clinical AC2 samples and 225 analytical samples spiked with phenotypically and/or genetically diverse NG and CT strains, and other potentially cross-reacting microbial species. Read More

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http://dx.doi.org/10.1186/s12879-020-05148-7DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7298785PMC
June 2020
2.613 Impact Factor

Human adenovirus Coinfection aggravates the severity of Mycoplasma pneumoniae pneumonia in children.

BMC Infect Dis 2020 Jun 16;20(1):420. Epub 2020 Jun 16.

National Clinical Research Center for Respiratory Diseases, Key Laboratory of Major Diseases in Children, Ministry of Education, Beijing Key Laboratory of Pediatric Respiratory Infection diseases, Research Unit of Critical Infection in Children, Chinese Academy of Medical Sciences, 2019RU016, Laboratory of Infection and Virology, Beijing Pediatric Research Institute, Beijing Children's Hospital, Capital Medical University, National Center for Children's Health, Beijing, China.

Background: Mycoplasma pneumoniae (M. pneumoniae) is an important pathogen of community-acquired pneumonia (CAP) in children. The coinfection rate of M. Read More

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http://dx.doi.org/10.1186/s12879-020-05152-xDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7296888PMC

Health status of free-ranging ring-necked pheasant chicks (Phasianus colchicus) in North-Western Germany.

PLoS One 2020 16;15(6):e0234044. Epub 2020 Jun 16.

Institute for Terrestrial and Aquatic Wildlife Research, University of Veterinary Medicine Hannover, Hannover, Germany.

Being a typical ground-breeding bird of the agricultural landscape in Germany, the pheasant has experienced a strong and persistent population decline with a hitherto unexplained cause. Contributing factors to the ongoing negative trend, such as the effects of pesticides, diseases, predation, increase in traffic and reduced fallow periods, are currently being controversially discussed. In the present study, 62 free-ranging pheasant chicks were caught within a two-year period in three federal states of Germany; Lower Saxony, North Rhine-Westphalia and Schleswig-Holstein. Read More

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http://journals.plos.org/plosone/article?id=10.1371/journal.pone.0234044PLOS
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7297342PMC

[Practice and thinking of acute respiratory infection surveillance for the response of emerging respiratory diseases in Shanghai].

Zhonghua Liu Xing Bing Xue Za Zhi 2020 Jun 16;41(0):E073. Epub 2020 Jun 16.

Shanghai Institute of Prevention Medicine, Shanghai 200336, China; School of Public Health,Fudan University,Shanghai 200032. China.

Shanghai Municipal Center for Disease Control and Prevention has implemented an active comprehensive surveillance project of acute respiratory infections in adults in Shanghai, including influenza like illness (ILI) and severe acute respiratory infection (SARI). By testing and identifying a variety of respiratory pathogens, it was found that influenza viruses were the main pathogens in 172 ILI cases in 2019. The positive rates of influenza A (H1N1) pdm09 virus, influenza A (H3N2) virus and influenza B virus Victoria lineage were 30. Read More

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http://dx.doi.org/10.3760/cma.j.cn112338-20200421-00616DOI Listing

Antibodies against atypical pathogens and respiratory viruses detected by Pneumoslide IgM test in adults with community-acquired pneumonia in Guangzhou City.

J Clin Lab Anal 2020 Jun 14:e23419. Epub 2020 Jun 14.

Department of Laboratory Medicine, The Second Affiliated Hospital of Guangzhou University of Chinese Medicine, Guangzhou, China.

Background: To detect the serum antibodies against respiratory viruses and atypical pathogens in adults with community-acquired pneumonia (CAP) in Guangzhou City (Guangdong province, China).

Methods: A retrospective study was carried out with samples from 685 adults who were admitted with CAP and 108 non-CAP control patients. Atypical pathogens and respiratory viruses in serum were detected using the Pneumoslide IgM test from Vircell, Spain. Read More

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http://dx.doi.org/10.1002/jcla.23419DOI Listing

Efficacy of delafloxacin versus moxifloxacin against atypical bacterial respiratory pathogens in adults with community-acquired bacterial pneumonia (CABP): Data from the Delafloxacin Phase 3 CABP Trial.

Int J Infect Dis 2020 Jun 10;97:374-379. Epub 2020 Jun 10.

Melinta Therapeutics, Morristown, NJ, USA. Electronic address:

Objectives: To report atypical pathogens from clinical trial data comparing delafloxacin to moxifloxacin in the treatment of adults with community-acquired bacterial pneumonia (CABP).

Methods: Multiple diagnostic methods were employed to diagnose atypical infections including culture, serology, and urinary antigen.

Results: The microbiological intent-to-treat (MITT) population included 520 patients; 30% had an atypical bacterial pathogen identified (156/520). Read More

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http://dx.doi.org/10.1016/j.ijid.2020.06.018DOI Listing

Major cluster of paediatric 'true' primary chilblains during the COVID-19 pandemic: a consequence of lifestyle changes due to lockdown.

J Eur Acad Dermatol Venereol 2020 Jun 13. Epub 2020 Jun 13.

Pediatric Emergency Unit, Department of Medical and Surgical Sciences (DIMEC), St. Orsola-Malpighi Hospital, University of Bologna, Bologna, Italy.

Background: Over the last months, during the COVID-19 pandemic, a growing number of chilblain-like lesions were reported mainly in children and rarely in young adults. The relationship with SARS-CoV-2 infection was postulated, often without any laboratory, instrumental or clinical confirmation. The disclosure of information about chilblain-like lesions as a COVID-19 manifestation in social media has created concern in children's families and paediatricians. Read More

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http://dx.doi.org/10.1111/jdv.16751DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7323208PMC

Lascufloxacin hydrochloride to treat bacterial infection.

Drugs Today (Barc) 2020 Jun;56(6):365-376

Division of Microbiology, CSIR-Central Drug Research Institute, Lucknow, Uttar Pradesh, India.

Lascufloxacin hydrochloride (AM-1977) is a novel 8-methoxy fluoroquinolone antibacterial agent with a unique pharmacophore at the 1st and 7th positions of the quinoline nucleus developed by Kyorin Pharmaceutical Co., Ltd. (Tokyo, Japan). Read More

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http://dx.doi.org/10.1358/dot.2020.56.6.3137167DOI Listing

Mycoplasma genitalium and Trichomonas vaginalis: addressing disparities and promoting public health control of two emerging sexually transmitted infections.

Curr Opin Pediatr 2020 Jun 8. Epub 2020 Jun 8.

Adolescent Medicine, John Hopkins University School of Medicine.

Purpose Of Review: Mycoplasma genitalium (M. genitalium) and Trichomonas vaginalis (T. vaginalis), sexually transmitted infections that remain non-reportable in the United States, may lead to pelvic inflammatory disease (PID) and adverse pregnancy outcomes if left untreated. Read More

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http://dx.doi.org/10.1097/MOP.0000000000000909DOI Listing

Herpes associated erythema multiforme: A retrospective study.

Am J Emerg Med 2020 May 29. Epub 2020 May 29.

University of Southern California Keck School of Medicine, Department of Dermatology, United States of America.

Background: Erythema multiforme (EM), an acute dermatologic condition frequently encountered in the Emergency Department, classically presents with a targetoid rash. We reviewed all recent EM cases seen at the LAC-USC County Hospital in order to ascertain the proportion of Herpes associated EM (HAEM) cases and to inform the diagnostic workup of these patients.

Methods: ICD-9 and ICD-10 codes were used to extract a list of EM cases at our institution from 2013 to 2019. Read More

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http://dx.doi.org/10.1016/j.ajem.2020.05.084DOI Listing

Clinical diagnostic application of metagenomic next-generation sequencing in children with severe nonresponding pneumonia.

PLoS One 2020 4;15(6):e0232610. Epub 2020 Jun 4.

Department of Respiratory Diseases, Shenzhen Children's Hospital, Shenzhen, China.

Pneumonia is one of the most important causes of morbidity and mortality in children. Identification and characterization of pathogens that cause infections are crucial for accurate treatment and accelerated recovery. However, in most cases, the causative agent cannot be identified, which is partly due to the limited spectrum of pathogens covered by current diagnostics based on nucleic acid amplification. Read More

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http://journals.plos.org/plosone/article?id=10.1371/journal.pone.0232610PLOS
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7272011PMC

Plastic bronchitis associated with adenovirus serotype 7 in children.

BMC Pediatr 2020 Jun 3;20(1):268. Epub 2020 Jun 3.

Department of Infectious Diseases, Xiamen Children's Hospital (Children's Hospital of Fudan University Xiamen Branch), 92 Yibin Road, Huli District, Xiamen City, 361006, Fujian Province, China.

Background: Plastic bronchitis is an uncommon but severe respiratory disease characterized by formation of casts in tracheobronchial tree. It can lead to airway obstruction and even respiratory failure.

Case Presentation: Plastic bronchitis is mostly seen in both post-cardiac surgery patients, especially Fontan procedure, and infections including those caused by influenza viruses, Mycoplasma pneumoniae or tuberculosis. Read More

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http://dx.doi.org/10.1186/s12887-020-02119-4DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7268262PMC

Association of sexually transmitted infections and human papillomavirus co-infection with abnormal cervical cytology among women in Saudi Arabia.

Saudi J Biol Sci 2020 Jun 19;27(6):1587-1595. Epub 2020 Mar 19.

Department of Infection and Immunity, King Faisal Specialist Hospital and Research Center, Riyadh, Saudi Arabia.

Human papillomavirus (HPV) is a causative agent of cervical and other cancers. Sexually transmitted Infections (STIs) may play a crucial role in HPV persistence, leading to serious complications, including cervical cancer. This study investigated the association of HPV/STI co-infection in cervical samples with cervical dysplasia among women in Saudi Arabia. Read More

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http://dx.doi.org/10.1016/j.sjbs.2020.03.021DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7253883PMC

Co-infections among patients with COVID-19: The need for combination therapy with non-anti-SARS-CoV-2 agents?

J Microbiol Immunol Infect 2020 May 23. Epub 2020 May 23.

Departments of Laboratory Medicine and Internal Medicine, National Taiwan University Hospital, National Taiwan University College of Medicine, Taipei, Taiwan. Electronic address:

Co-infection has been reported in patients with severe acute respiratory syndrome (SARS) and Middle East respiratory syndrome, but there is limited knowledge on co-infection among patients with coronavirus disease 2019 (COVID-19). The prevalence of co-infection was variable among COVID-19 patients in different studies, however, it could be up to 50% among non-survivors. Co-pathogens included bacteria, such as Streptococcus pneumoniae, Staphylococcus aureus, Klebsiella pneumoniae, Mycoplasma pneumoniae, Chlamydia pneumonia, Legionella pneumophila and Acinetobacter baumannii; Candida species and Aspergillus flavus; and viruses such as influenza, coronavirus, rhinovirus/enterovirus, parainfluenza, metapneumovirus, influenza B virus, and human immunodeficiency virus. Read More

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http://dx.doi.org/10.1016/j.jmii.2020.05.013DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7245213PMC

Efficacy and safety of azithromycin combined with glucocorticoid on refractory Mycoplasma pneumoniae pneumonia in children: A PRISMA-compliant systematic review and meta-analysis.

Medicine (Baltimore) 2020 May;99(22):e20121

Department of Pediatrics, First Affiliated Hospital of Henan University of Chinese Medicine, Zhengzhou City, Henan Province.

Introduction: The aim of this study was to evaluate the efficacy and safety of azithromycin (AZI) combined with glucocorticoid (GC) in the treatment of children with refractory Mycoplasma pneumoniae.

Methods: Computer search for PubMed, EMbase, Cochrane Library, China Biomedical Literature Database (CBMdisc), China Knowledge Network (CNKI), Wanfang, VIP (VIP), and a randomized controlled trial (RCT) of AZI combined with GC in the treatment of children with refractory Mycoplasma pneumoniae pneumonia test (RCT), the search time limit is built until March 20, 2019. Two researchers independently performed literature screening, data extraction, and literature risk bias, and meta-analysis was performed using RevMan 5. Read More

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http://dx.doi.org/10.1097/MD.0000000000020121DOI Listing

Co-infections in people with COVID-19: a systematic review and meta-analysis.

J Infect 2020 May 27. Epub 2020 May 27.

Department of Respiratory Medicine, Nottingham University Hospitals NHS Trust, Nottingham, UK. Electronic address:

Objectives: In previous influenza pandemics, bacterial co-infections have been a major cause of mortality. We aimed to evaluate the burden of co-infections in patients with COVID-19.

Methods: We systematically searched Embase, Medline, Cochrane Library, LILACS and CINAHL for eligible studies published from 1 January 2020 to 17 April 2020. Read More

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http://dx.doi.org/10.1016/j.jinf.2020.05.046DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7255350PMC

Age specific evaluation of sexual behavior, STI knowledge and infection among asymptomatic adolescents and young adults.

J Infect Public Health 2020 May 26. Epub 2020 May 26.

Walk In Ruhr (WIR), Center for Sexual Health and Medicine, Bochum, Germany; Interdisciplinary Immunological Outpatient Clinic, Center for Sexual Health and Medicine, Department of Dermatology, Venereology and Allergology, Ruhr Universität Bochum, Germany. Electronic address:

Objectives: Adolescents and young adults account for 50% of new infections with sexually transmitted infection (STI), while representing only 25% of the sexually active population. An evaluation of sexual behavior, STI knowledge and infection among youth of different age groups is relevant to formulate effective sexual health strategies.

Methods: In this monocentric, open, prospective cross-sectional study, 268 asymptomatic subjects (14-30 years) were partitioned into three cohorts I: 14-19 (n=42), II: 20-25 (n=147) and III: 25-30 (n=79) years. Read More

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http://dx.doi.org/10.1016/j.jiph.2020.04.005DOI Listing

Erythema multiforme, Stevens-Johnson syndrome/toxic epidermal necrolysis - diagnosis and treatment.

J Dtsch Dermatol Ges 2020 Jun 29;18(6):547-553. Epub 2020 May 29.

Department of Dermatology and Venereology, University Medical Center, Rostock, Germany.

Prior to the first international consensus classification published in 1993, the clinical distinction between erythema multiforme (EM), Stevens-Johnson syndrome (SJS) and toxic epidermal necrolysis (TEN) had been subject to uncertainty and controversy for more than a century. Based on this classification, the three conditions are defined by the morphology of the individual lesions and their pattern of distribution. Etiopathogenetically, the majority of EM cases is caused by infections (primarily herpes simplex virus and Mycoplasma pneumoniae), whereas SJS/TEN are predominantly triggered by drugs. Read More

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http://dx.doi.org/10.1111/ddg.14118DOI Listing

Viruses and atypical bacteria in the respiratory tract of immunocompromised and immunocompetent patients with airway infection.

Eur J Clin Microbiol Infect Dis 2020 Aug 27;39(8):1581-1592. Epub 2020 May 27.

Institute of Infection Medicine, Christian-Albrechts-Universität zu Kiel and University Medical Center Schleswig-Holstein, Brunswiker Straße 4, D-24105, Kiel, Germany.

Respiratory tract infections (RTI) can take a serious course under immunosuppression. Data on the impact of the underlying pathogens are still controversial. Samples from the upper (n = 322) and lower RT (n = 169) were collected from 136 children and 355 adults; 225 among them have been immunocompromised patients. Read More

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http://dx.doi.org/10.1007/s10096-020-03878-9DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7253234PMC

Molecular epidemiology and socio-demographic risk factors of sexually transmitted infections among women in Lebanon.

BMC Infect Dis 2020 May 27;20(1):375. Epub 2020 May 27.

Faculty of Health Sciences, University of Balamand, P.O.Box 166378 Ashrafieh, Beirut, 1100-2807, Lebanon.

Background: Sexually transmitted infections (STIs) cause a major public health problem that affect both men and women in developing and developed countries. The aim of the study was to estimate the prevalence of 11 STIs among women who voluntarily participated in the study, while seeking gynecological checkup. The existence of an association between the presence of pathogens and symptoms and various sociodemographic risk factors was assessed. Read More

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http://dx.doi.org/10.1186/s12879-020-05066-8DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7251815PMC

Clinical evaluation of the ResistancePlus MG FleXible test on the GeneXpert Infinity-48s instrument: a near-patient assay for simultaneous detection of Mycoplasma genitalium and macrolide resistance.

Diagn Microbiol Infect Dis 2020 Apr 17:115062. Epub 2020 Apr 17.

Microbiology Department, Vall d´Hebron University Hospital, Universitat Autònoma de Barcelona, Barcelona, Spain. Electronic address:

Antibiotic resistance in Mycoplasma genitalium (MG) is rising globally, especially to macrolides. In response to this challenge, assays reporting both the detection of MG and macrolide resistance-mediating mutations (MRMM) allow therapy to be tailored to the individual. The study evaluated the performance of the ResistancePlus® MG FleXible assay for the detection of MG and MRMM. Read More

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http://dx.doi.org/10.1016/j.diagmicrobio.2020.115062DOI Listing

Early diagnosis and appropriate respiratory support for Mycoplasma pneumoniae pneumonia associated acute respiratory distress syndrome in young and adult patients: a case series from two centers.

BMC Infect Dis 2020 May 24;20(1):367. Epub 2020 May 24.

Department of Respiratory and Critical Care Medicine, Beijing Institute of Respiratory Medicine, Beijing Key Laboratory of Respiratory and Pulmonary Circulation, Beijing Chao-Yang Hospital, Capital Medical University, No. 8 Gongren Tiyuchang Nanlu, Chaoyang District, Beijing, 100020, China.

Background: Mycoplasma pneumoniae (M. pneumoniae) is one of the most common causes of community acquired pneumonia (CAP). Establishing an early diagnosis of M. Read More

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http://dx.doi.org/10.1186/s12879-020-05085-5DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7245847PMC
May 2020
2.613 Impact Factor

Recent clinical relevance of mono-genital colonization/infection by Ureaplasma parvum.

Eur J Clin Microbiol Infect Dis 2020 May 21. Epub 2020 May 21.

Department of Microbiology, School of Medicine, University of Granada-Instituto de Investigación Biosanitaria de Granada.ibs, Granada, Spain.

Ureaplasma parvum is the most prevalent genital mycoplasma in women of childbearing age. There is debate around the relevance of its presence in male or female genitals for disease development and as a cofactor. The objective of this study was to determine the prevalence of colonization/infection by U. Read More

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http://dx.doi.org/10.1007/s10096-020-03928-2DOI Listing
May 2020
2.668 Impact Factor

Microbial diversity involved in the etiology of a bovine respiratory disease outbreak in a dairy calf rearing unit.

Comp Immunol Microbiol Infect Dis 2020 May 11;71:101494. Epub 2020 May 11.

Laboratory of Animal Virology, Department of Veterinary Preventive Medicine, Universidade Estadual de Londrina, Brazil; Multi-User Animal Health Laboratory, Molecular Biology Unit, Department of Veterinary Preventive Medicine, Universidade Estadual de Londrina, Brazil; National Institute of Science and Technology for Dairy Production Chain, (INCT - LEITE), Universidade Estadual de Londrina, Brazil.

The etiological agents involved in a bovine respiratory disease (BRD) outbreak were investigated in a dairy heifer calf rearing unit from southern Brazil. A battery of PCR assays was performed to detect the most common viruses and bacteria associated with BRD, such as bovine viral diarrhea virus (BVDV), bovine respiratory syncytial virus (BRSV), bovine alphaherpesvirus 1 (BoHV-1), bovine coronavirus (BCoV), bovine parainfluenza virus 3 (BPIV-3), Mannheimia haemolytica, Pasteurella multocida, Histophilus somni, and Mycoplasma bovis. Bronchoalveolar lavage fluid (BALF) samples were taken from 21 heifer calves (symptomatic n = 15; asymptomatic n = 6) that, during the occurrence of the BDR outbreak, were aged between 6 and 90 days. Read More

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http://dx.doi.org/10.1016/j.cimid.2020.101494DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7212942PMC

Emerging and Reemerging Sexually Transmitted Infections.

N Engl J Med 2020 05;382(21):2023-2032

From the Department of Microbiology and Immunology, University of Melbourne at the Peter Doherty Institute for Infection and Immunity, and the Department of Microbiology, Royal Melbourne Hospital (D.A.W.), and Melbourne Sexual Health Centre, Alfred Health, and Central Clinical School, Monash University (M.Y.C.) - all in Melbourne, VIC, Australia.

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http://dx.doi.org/10.1056/NEJMra1907194DOI Listing

Pathogen analysis of pertussis-like syndrome in children.

BMC Infect Dis 2020 May 19;20(1):353. Epub 2020 May 19.

Department of Respiration, Children's Hospital of Soochow University, No. 303 Jing De Road, Suzhou, 215003, China.

Background: The aim of the study was to identify the pathogens, in addition to bordetella pertussis (B. pertussis), which cause pertussis-like syndrome in children and to compare clinical presentation between those with B. pertussis and pertussis-like syndrome. Read More

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http://dx.doi.org/10.1186/s12879-020-05074-8DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7236299PMC

biofilms grown : traits associated with persistence and cytotoxicity.

Microbiology 2020 May 18. Epub 2020 May 18.

Department of Microbiology, Miami University, 212 Pearson Hall, Oxford, OH 45056, USA.

The atypical bacterial pathogen is a leading etiological agent of community-acquired pneumonia in humans; infections are often recalcitrant, recurrent and resistant to antibiotic treatment. These characteristics suggest a mechanism that facilitates long-term colonization in hosts. In an setting, forms biofilms that are unusual in that motility plays no more than a very limited role in their formation and development. Read More

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http://dx.doi.org/10.1099/mic.0.000928DOI Listing

Does vaccination with the live mycoplasma vaccine MSH increase the pathogenicity of Avian influenza infections?

Authors:
Chris J Morrow

Poult Sci 2020 Jan 30;99(1). Epub 2019 Dec 30.

Bioproperties Pty Ltd, 36 Charter St, Ringwood, Victoria 3136, Australia; Melbourne Veterinary School, Faculty of Veterinary and Agricultural Sciences, The University of Melbourne, Parkville, Victoria 3010, Australia. Electronic address:

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http://dx.doi.org/10.3382/ps/pez550DOI Listing
January 2020