592 results match your criteria Mycobacterium Xenopi


A case of pulmonary infection in a healthy Japanese man.

Respir Med Case Rep 2020 16;30:101093. Epub 2020 May 16.

Division of Respirology, Neurology and Rheumatology, Department of Medicine, Kurume University School of Medicine, Fukuoka, 830-0011, Japan.

A 72-year-old man, healthy, smoker, with long-standing cough, was referred to our hospital and his chest X-ray (CXR) revealed a cavity lesion in the right upper lobe. Direct sputum smears, but not culture in solid medium, were positive for acid-fast bacilli (AFB) without tuberculosis DNA. The preliminary diagnosis was of a non-tuberculosis infection that progressed slowly, and the CXR showed the condition to worsen daily. Read More

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http://dx.doi.org/10.1016/j.rmcr.2020.101093DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7256317PMC

[Pathological characteristics and molecular diagnosis of non-tuberculosis lung disease].

Zhonghua Bing Li Xue Za Zhi 2020 Jun;49(6):562-567

Department of Pathology, Beijing Chest Hospital, Capital Medical University; Beijing Tuberculosis and Thoracic Tumor Research Institute, Beijing 101149, China.

To investigate the clinicopathological features of non-tuberculosis mycobacterial lung disease and the role of molecular pathology in diagnosis. Forty-five formalin-fixed, paraffin embedded (FFPE) specimens were collected from the Department of Pathology, Beijing Chest Hospital from February 2016 to August 2019. The clinical, imaging and histopathologic features, bacteriologic data and morphologic characteristics of acid fast bacilli (AFB) were analyzed retrospectively. Read More

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http://dx.doi.org/10.3760/cma.j.cn112151-20191028-00669DOI Listing

Non-tuberculous mycobacterial pulmonary disease: an Italian National survey.

Sarcoidosis Vasc Diffuse Lung Dis 2018 28;35(1):21-25. Epub 2018 Apr 28.

Dipartimento Cardio-Toraco-Vascolare, University of Milan Bicocca, Respiratory Unit, San Gerardo Hospital, ASST di Monza, Monza, Italy.

The incidence of non-tuberculous mycobacteria (NTM) infection is increasing in Europe. However, a picture of Italian epidemiology and clinical practice is missing. We performed a national Italian survey involving 42 respiratory medicine departments. Read More

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http://dx.doi.org/10.36141/svdld.v35i1.6979DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7170062PMC

Clinical outcomes in Mycobacterium xenopi versus Mycobacterium avium complex pulmonary disease: A retrospective matched cohort study.

Respir Med 2020 Jun 15;167:105967. Epub 2020 Apr 15.

Division of Respirology, Department of Medicine, University of Toronto, Toronto, Canada; Division of Respirology, Department of Medicine, Toronto Western Hospital, Toronto, Canada.

Mycobacterium xenopi is associated with the highest mortality among pulmonary nontuberculous mycobacterial (NTM) infections, but whether this is due to the infection or other factors is unclear. There is little information regarding outcomes among patients infected with M. xenopi versus other NTM species. Read More

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http://dx.doi.org/10.1016/j.rmed.2020.105967DOI Listing

Prolongation of incubation time improves clinical diagnosis of Mycobacterium xenopi infection, and allows susceptibility testing of mycobacterial strains against multiple antibiotics.

J Glob Antimicrob Resist 2020 May 5. Epub 2020 May 5.

Chemical-clinical and Microbiological Analysis, ASST Grande Ospedale Metropolitano Niguarda, Milan, Italy.

Objectives: Mycobacterium xenopi (M. xenopi) is a non-tubercolar mycobacterium (NTM) whose clinical diagnosis and drug-sensitivity studies are frequently hampered by poor in vitro growth. Extending culture incubation from 42 (common-standard) to 56 days could improve chances of diagnosis, and provide strains for phenotypic drug-sensitivity profiling of this poorly studied, but clinically-relevant mycobacterium. Read More

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http://dx.doi.org/10.1016/j.jgar.2020.04.028DOI Listing

Recent increase in non-tuberculous mycobacterial infection in patients with connective tissue diseases in Japan.

J Infect Chemother 2020 May 3. Epub 2020 May 3.

Department of Internal Medicine, Teikyo University, 2-11-1, Kaga, Itabashi-ku, Tokyo, Japan; National Hospital Organization Higashisaitama Hospital, Hasuda, 4147, Kurohama, Saitama, Japan.

Background: Non-tuberculous mycobacterial (NTM) infection is currently a growing health concern due to the increasing incidence and the need for prolonged therapy. In patients with connective tissue diseases, use of immunosuppressants may lead to an increased risk of NTM infection. However, few studies have examined the recent incidence of NTM infection among connective tissue diseases patients. Read More

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http://dx.doi.org/10.1016/j.jiac.2020.04.013DOI Listing

Complete Genome Sequence of Mycobacterium xenopi JCM15661, Obtained Using Nanopore and Illumina Sequencing Technologies.

Microbiol Resour Announc 2020 Mar 5;9(10). Epub 2020 Mar 5.

Department of Mycobacteriology, Leprosy Research Center, National Institute of Infectious Diseases, Tokyo, Japan

is a slow-growing mycobacterial organism for which pathogenic features are unclear. Here, we report the complete genome sequence of an type strain. This sequence will provide essential information for future taxonomic and comparative genome studies of these mycobacteria. Read More

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http://dx.doi.org/10.1128/MRA.01583-19DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7171225PMC

A Chimeric EccB-MycP Fusion Protein is Functional and a Stable Component of the ESX-5 Type VII Secretion System Membrane Complex.

J Mol Biol 2020 Feb 14;432(4):1265-1278. Epub 2020 Jan 14.

Section Molecular Microbiology, Amsterdam Institute of Molecular and Life Sciences, Vrije Universiteit Amsterdam, De Boelelaan 1108, 1081 HZ Amsterdam, the Netherlands. Electronic address:

The mycosin protease (MycP) is widely conserved in type VII secretion (T7S) systems throughout Actinobacteria. Within the T7S systems of mycobacteria, also known as the ESX systems, MycP is essential for secretion, which is probably linked to its stabilizing effect on the ESX membrane complex. However, it is unknown how this is mediated, as MycP is not a stable component of this complex. Read More

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http://dx.doi.org/10.1016/j.jmb.2019.12.040DOI Listing
February 2020

Clinical relevance of pulmonary non-tuberculous mycobacterial isolates in three reference centres in Belgium: a multicentre retrospective analysis.

BMC Infect Dis 2019 Dec 17;19(1):1061. Epub 2019 Dec 17.

Department of Respiratory Diseases, University Hospitals Leuven, Herestraat 49, B3000, Leuven, Belgium.

Background/objectives: Assessing the clinical relevance of non-tuberculous mycobacteria (NTM) isolated from respiratory samples can be challenging. The epidemiology and pathogenicity of NTM species vary geographically. We aimed to outline the clinical relevance and associated radiological patterns of NTM species isolated in Belgium. Read More

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http://dx.doi.org/10.1186/s12879-019-4683-yDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6918577PMC
December 2019

Socio-Economic and Environmental Factors Related to Spatial Differences in Human Non-Tuberculous Mycobacterial Diseases in the Czech Republic.

Int J Environ Res Public Health 2019 10 17;16(20). Epub 2019 Oct 17.

Faculty of Regional Development and International Studies, Mendel University in Brno, Tr. Generala Piky 7, 613 00 Brno, Czech Republic.

Non-tuberculous mycobacteria (NTM) are ubiquitous environmental bacteria that can induce pulmonary and non-pulmonary diseases in susceptible persons. It is reported that the prevalence of NTM diseases is increasing in developed countries, but this differs by regions and countries. NTM species distribution and the rate of diseases caused by NTM vary widely in the historical territories of Moravia and Silesia (Czech Republic). Read More

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http://dx.doi.org/10.3390/ijerph16203969DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6843547PMC
October 2019
1 Read

Mycobacterium Spindle Cell Pseudotumor Caused by : A First Described Association of a Rare Entity Presenting in the Lung.

Int J Surg Pathol 2020 May 10;28(3):316-320. Epub 2019 Oct 10.

Rush University Medical Center, Chicago, IL, USA.

Mycobacterial spindle cell pseudotumor (MSP) is a rare benign lesion characterized by a proliferation of bland spindle-shaped histiocytes with vague granulomatous formation, positive for acid-fast bacilli staining. This lesion is usually reported in the lymph nodes and skin of immunocompromised patients; only 6 cases primary in the lung have been reported in the English literature to this date. In this article, we present the case of a 42-year-old female status post failed kidney-pancreas transplant with subsequent multiple kidney transplants, on chronic immunosuppression, who developed a mass in the left lower lobe consistent with MSP. Read More

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http://dx.doi.org/10.1177/1066896919879745DOI Listing
May 2020
1 Read
0.961 Impact Factor

Prescribing Patterns for Treatment of Mycobacterium avium Complex and M. xenopi Pulmonary Disease in Ontario, Canada, 2001-2013.

Emerg Infect Dis 2019 07;25(7)

Surveys suggest that clinicians diverge from guidelines when treating Mycobacterium avium complex (MAC) pulmonary disease (PD). To determine prescribing patterns, we conducted a cohort study of adults >66 years of age in Ontario, Canada, with MAC or Mycobacterium xenopi PD during 2001-2013. Using linked laboratory and health administrative databases, we studied the first treatment episode (>60 continuous days of >1 of a macrolide, ethambutol, rifamycin, fluoroquinolone, linezolid, inhaled amikacin, or, for M. Read More

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http://dx.doi.org/10.3201/eid2507.181817DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6590764PMC
July 2019
7 Reads

Prosthetic joint infection due to Mycobacterium xenopi: a review of the literature with a new case report.

Infection 2020 Apr 16;48(2):165-171. Epub 2019 May 16.

Dipartimento di Malattie Infettive-Tropicali e Microbiologia, Centro per le Malattie Tropicali, IRCCS Ospedale Sacro Cuore Don Calabria, Via Sempreboni 5, 37024, Negrar, Verona, Italy.

Purpose: Extrapulmonary infections due to M. xenopi, particularly osteoarticular localizations, are rare. The purpose of this paper is to describe a case of prosthetic hip infection and to review the published literature on cases of M. Read More

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http://dx.doi.org/10.1007/s15010-019-01318-1DOI Listing
April 2020
8 Reads

The Hippocratic Splash.

Eur J Case Rep Intern Med 2018 28;5(11):000975. Epub 2018 Nov 28.

Department of Pneumology, Centro Hospitalar do Médio Tejo, Abrantes, Portugal.

Although the current medical literature is limited, hydropneumothorax was described as far back as the 5th century BC. It is characterized by the presence of air and fluid in the pleural cavity and is an infrequent finding. Causes include trauma, iatrogenesis following thoracentesis, the presence of gas-forming organisms, tuberculosis and malignancy. Read More

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http://dx.doi.org/10.12890/2018_000975DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6346804PMC
November 2018
23 Reads

Pulmonary Cavitary Disease Secondary to Mycobacterium xenopi Complicated by Respiratory Failure.

Cureus 2018 Oct 29;10(10):e3512. Epub 2018 Oct 29.

Internal Medicine, Staten Island University Hospital, Northwell Health, Staten Island, USA.

Non-tuberculous mycobacteria (NTM) are a significant cause of pulmonary infection worldwide and can be clinically challenging. Mycobacterium xenopi (M. xenopi) has low pathogenicity and usually requires either host immune impairment, as in the case of a human immunodeficiency virus infection, or a structural lung disease to cause a clinical disease. Read More

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https://www.cureus.com/articles/14545-pulmonary-cavitary-dis
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http://dx.doi.org/10.7759/cureus.3512DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6318116PMC
October 2018
41 Reads

Radiologic types of Mycobacterium xenopi pulmonary disease: different patients with similar short-term outcomes.

Eur J Clin Microbiol Infect Dis 2019 Feb 14;38(2):373-381. Epub 2018 Dec 14.

Division of Respirology, Department of Medicine, University of Toronto, Toronto, ON, Canada.

Mycobacterium xenopi pulmonary disease (Mxe-PD) is common among nontuberculous mycobacterial infections in Europe and Canada. Associations between radiological pattern and clinical features and outcomes are inadequately studied in Mxe-PD. We sought to investigate clinical characteristics and outcomes according to the dominant radiological pattern among patients with Mxe-PD. Read More

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http://dx.doi.org/10.1007/s10096-018-3437-xDOI Listing
February 2019
8 Reads

Drug Susceptibility of Non-tuberculous Strains of Isolated from Birds from Poland.

Pol J Microbiol 2018;67(4):487-492

Department of Pathology and Veterinary Diagnostics, Warsaw University of Life Sciences , Warsaw , Poland.

Mycobacterioses are a constant problem in backyard poultry, as well as pet birds. To date, no evidence of direct transmission of atypical bacilli between humans has been demonstrated, but it cannot be ruled out that sick animals can be a source of infection for people in their environment. The aim of the study was to identify mycobacteria isolated from birds with diagnosed mycobacteriosis and to determine the susceptibility of mycobacterial isolates from these animals to antituberculous drugs most commonly used in the treatment of mycobacterial infections in humans. Read More

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https://www.exeley.com/polish_journal_of_microbiology/doi/10
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http://dx.doi.org/10.21307/pjm-2018-057DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7256868PMC
June 2019
46 Reads

systemic infection in a domestic fiery-shouldered conure bird ().

JMM Case Rep 2018 Jul 4;5(7):e005158. Epub 2018 Jul 4.

Laboratoire de santé animale (LSA-St-Hyacinthe), Ministère de l'Agriculture des Pêcheries et de l'Alimentation du Québec, Canada.

Introduction: is a rare opportunistic pathogen mainly causing infections in immunocompromised human patients or those with underlying chronic structural lung disease. Cases of disease in veterinary medicine remain scarce. Few animal species, including birds, are suspected of being vectors of the disease and there has not yet been a report of clinical disease in birds. Read More

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http://dx.doi.org/10.1099/jmmcr.0.005158DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6159546PMC
July 2018
8 Reads

Drug susceptibility testing of slowly growing non-tuberculous mycobacteria using slomyco test-system.

PLoS One 2018 17;13(9):e0203108. Epub 2018 Sep 17.

Department of problems of laboratory diagnostics of tuberculosis and pathomorphology, Scientific and Clinical Antituberculosis Center of Moscow Government Health Department, Moscow, Russian Federation.

Objective: The objective of the research was to assess the susceptibility of the slowly growing nontuberculous mycobacteria strains to the antimicrobial drugs used for mycobaterioses treatment using SLOMYCO test system.

Materials And Methods: We assessed 363 NTM strains: 177 MAC (161 M. avium, 16 M. Read More

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http://journals.plos.org/plosone/article?id=10.1371/journal.pone.0203108PLOS
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6141080PMC
February 2019
28 Reads

Adjuvant lung resection in the management of nontuberculous mycobacterial lung infection: A retrospective matched cohort study.

Respir Med 2018 09 9;142:1-6. Epub 2018 Jul 9.

Division of Respirology, Department of Medicine, University Health Network, Toronto Western Hospital, 399 Bathurst Street, Toronto, ON, M5T 2S8, Canada; Department of Medicine, University of Toronto, 27 King's College Circle, Toronto, ON, M5S 1A1, Canada. Electronic address:

Background And Objectives: Lung resection in patients with nontuberculous mycobacterial pulmonary disease (NTM-PD) is considered when medical therapy alone fails to provide long term control. Data regarding comparative and long-term outcomes are limited. We aimed to review indications and outcomes of adjuvant lung resection for NTM-PD compared with controls. Read More

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http://dx.doi.org/10.1016/j.rmed.2018.07.003DOI Listing
September 2018
22 Reads

Six species of nontuberculous mycobacteria carry non-identical 16S rRNA gene copies.

J Microbiol Methods 2018 12 27;155:34-36. Epub 2018 Aug 27.

Department of Mycobacterium Reference and Research, The Research Institute of Tuberculosis, 3-1-24 Matsuyama, Kiyose, Tokyo 204-0022, Japan; Department of Basic Mycobacteriology, Graduate School of Biomedical Science, Nagasaki University, 1-12-4 Sakamoto, Nagasaki 852-8523, Japan. Electronic address:

Nontuberculous mycobacteria (NTM) can carry two or more 16S rRNA gene copies that are, in some instances, non-identical. In this study, we used a combined cloning and sequencing approach to analyze 16S rRNA gene sequences of six NTM species, Mycobacterium cosmeticum, M. pallens, M. Read More

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http://dx.doi.org/10.1016/j.mimet.2018.08.012DOI Listing
December 2018
13 Reads
2.030 Impact Factor

Treatment of Other Nontuberculous Mycobacteria.

Semin Respir Crit Care Med 2018 Jun 2;39(3):377-382. Epub 2018 Aug 2.

Department of Respiratory Diseases, Amiens University Hospital, Amiens, France.

Nontuberculous mycobacteria (NTM) are numerous, and for the vast majority of them, randomized studies are lacking and data regarding optimal treatment are limited. When complex (MAC) and are excluded, the main NTM are , and . Treatment is long (at least 12 months after culture conversion according to recommendations by scientific societies) and difficult (at least three drugs are required, each of which have potential adverse events). Read More

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http://www.thieme-connect.de/DOI/DOI?10.1055/s-0038-1660473
Publisher Site
http://dx.doi.org/10.1055/s-0038-1660473DOI Listing
June 2018
55 Reads

Comparison of polymerase chain reaction-restriction enzyme analysis method and DNA sequence analysis results in the identification of non-tuberculous mycobacteria.

Acta Microbiol Immunol Hung 2018 Dec 16;65(4):515-527. Epub 2018 Jul 16.

1 Department of Medical Microbiology, Dokuz Eylul University , İzmir, Turkey.

The typing of non-tuberculous mycobacteria (NTM) is important from a clinical and epidemiological perspective. The polymerase chain reaction-restriction enzyme analysis (PRA) method and DNA sequence analysis method were utilized to target a gene region that codes the 65-kDa heat-shock protein for typing 150 suspected NTM samples isolated from the respiratory tract. Mycobacterium abscessus, Mycobacterium xenopi, Mycobacterium fortuitum, and Mycobacterium peregrinum were most frequently found by both methods. Read More

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http://dx.doi.org/10.1556/030.65.2018.027DOI Listing
December 2018
26 Reads

Mycobacterium heckeshornense lung infection diagnosed by matrix-assisted laser desorption ionization-time of flight mass spectrometry (MALDI-TOF MS).

J Infect Chemother 2018 Sep 1;24(9):763-765. Epub 2018 Mar 1.

Department of Respiratory Medicine, The University of Tokyo, Japan.

Identification of microorganisms by matrix-assisted laser desorption ionization-time of flight mass spectrometry (MALDI-TOF MS) has been widely accepted. However, the significance of MALDI-TOF MS for identifying mycobacteria, particularly rare nontuberculous mycobacteria, has not been established. M. Read More

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https://linkinghub.elsevier.com/retrieve/pii/S1341321X183004
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http://dx.doi.org/10.1016/j.jiac.2018.01.017DOI Listing
September 2018
10 Reads
1.384 Impact Factor

Clinical features of infection caused by non-tuberculous mycobacteria: 7 years' experience.

Infection 2018 Jun 23;46(3):357-363. Epub 2018 Feb 23.

Department of Biomedical Sciences, University of Sassari, Sassari, Italy.

Introduction: Non-tuberculous mycobacteria (NTM) are ubiquitous organisms associated with various infections. The aim of the study was to determine the most relevant clinical characteristics of NTM during the 7-year period.

Methodology: A retrospective study of NTM infections was conducted between January 2009 and December 2016. Read More

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http://dx.doi.org/10.1007/s15010-018-1128-2DOI Listing
June 2018
56 Reads

Mycobacterium xenopi Genotype Associated with Clinical Phenotype in Lung Disease.

Lung 2018 04 18;196(2):213-217. Epub 2018 Jan 18.

Department of Laboratory Medicine and Pathobiology, University of Toronto, Toronto, ON, Canada.

Mycobacterium xenopi is responsible for pulmonary disease (PD) in Europe and Canada. Despite its high prevalence and increasing clinical importance, little is known about the genetic diversity of M. xenopi. Read More

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http://dx.doi.org/10.1007/s00408-018-0087-9DOI Listing
April 2018
11 Reads

Cavitary lung lesion suspicious for malignancy reveals .

Respir Med Case Rep 2018 3;23:83-85. Epub 2018 Jan 3.

GIM Foundation, Little Rock, AR, USA.

We report the case of a 68-year-old gentleman who presented with musculoskeletal chest pain which appeared suddenly when he bent over with his dog. The chest pain was localized to the left lower chest and increased with movement and deep breathing. The patient did not complain weight loss, night sweat, fever or chill. Read More

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http://dx.doi.org/10.1016/j.rmcr.2017.12.011DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5760466PMC
January 2018
24 Reads

Fatal pulmonary cavitary disease secondary to in a patient with sarcoidosis.

J Community Hosp Intern Med Perspect 2017 14;7(6):372-377. Epub 2017 Dec 14.

Pulmonary and Critical Care Department, Interfaith Medical Center, Brooklyn, NY, USA.

: () has low pathogenicity and usually requires either host immune impairment or structural lung disease to cause clinical disease. Fatal cavitary infection in a patient without immunosuppression is rarely presented. : A 62-year-old female with history of sarcoidosis and hypertension presented with cough, fever and dyspnea for one week. Read More

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https://www.tandfonline.com/doi/full/10.1080/20009666.2017.1
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http://dx.doi.org/10.1080/20009666.2017.1407211DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5738639PMC
December 2017
25 Reads

Evaluation of PyroMark Q24 pyrosequencing as a method for the identification of mycobacteria.

Diagn Microbiol Infect Dis 2018 Jan 15;90(1):35-39. Epub 2017 Sep 15.

Department of Mycobacterium Reference and Research, the Research Institute of Tuberculosis, Japan Anti-Tuberculosis Association, Kiyose, Japan; Basic Mycobacteriology, Graduate School of Biomedical Science, Nagasaki University, Nagasaki, Japan.

We evaluated PyroMark Q24 (QIAGEN) pyrosequencing as a method for the identification of mycobacteria, with potential application in clinical practice. Sequence data from the hypervariable region A of the 16S rRNA gene (43 and 35bp sequences) were obtained using PyroMark Q24, and a similarity search was performed automatically with PyroMark IdentiFire software. Of the 148 mycobacterial type strains tested, 138 (93. Read More

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http://dx.doi.org/10.1016/j.diagmicrobio.2017.09.002DOI Listing
January 2018
13 Reads

The new phylogeny of the genus Mycobacterium: The old and the news.

Infect Genet Evol 2017 12 11;56:19-25. Epub 2017 Oct 11.

Emerging Bacterial Pathogens Unit, IRCCS San Raffaele Scientific Institute, Milano, Italy. Electronic address:

Background: Phylogenetic studies of bacteria have been based so far either on a single gene (usually the 16S rRNA) or on concatenated housekeeping genes. For what concerns the genus Mycobacterium these approaches support the separation of rapidly and slowly growing species and the clustering of most species in well-defined phylogenetic groups. The advent of high-throughput shotgun sequencing leads us to revise conventional taxonomy of mycobacteria on the light of genomic data. Read More

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http://dx.doi.org/10.1016/j.meegid.2017.10.013DOI Listing
December 2017
38 Reads

Transmission of to a pet albino ferret () from a domestic aquarium.

Vet Rec 2017 Aug 3. Epub 2017 Aug 3.

Beaumont Sainsbury Animal Hospital, Royal Veterinary College, London, UK.

A three-year-old ferret presented with a three-month history of rapid clinical deterioration necessitating euthanasia shortly after initial veterinary assessment. Postmortem PCR testing confirmed which is most commonly identified in amphibians, reptiles and aquatic life. Infection of a captive-bred domestic ferret is highly unusual. Read More

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http://veterinaryrecord.bmj.com/lookup/doi/10.1136/vr.104250
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http://dx.doi.org/10.1136/vr.104250DOI Listing
August 2017
10 Reads

Mannich Ketones as Possible Antimycobacterial Agents.

Arch Pharm (Weinheim) 2017 Sep 28;350(9). Epub 2017 Jul 28.

Faculty of Medicine, Department of Biochemistry and Medical Chemistry, University of Pécs, Pécs, Hungary.

Twenty-three known unsaturated and fused Mannich ketones and their reduced derivatives (amino alcohols) were selected for an antituberculotic study. They were screened against several mycobacterial strains including Mycobacterium tuberculosis, M. xenopi, and M. Read More

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http://dx.doi.org/10.1002/ardp.201700102DOI Listing
September 2017
22 Reads

Mycobacterium xenopi and squamous cell carcinoma of the lung.

Arch Bronconeumol 2017 Dec 19;53(12):698-700. Epub 2017 Jun 19.

Servicio de Medicina Interna, Hospital Clínico Universitario de Valladolid, Valladolid, España.

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http://dx.doi.org/10.1016/j.arbres.2017.05.009DOI Listing
December 2017
8 Reads

Design, synthesis and evaluation of indole-2-carboxamides with pan anti-mycobacterial activity.

Bioorg Med Chem 2017 07 8;25(14):3746-3755. Epub 2017 May 8.

Department of Pharmacy Sciences, Creighton University, 2500 California Plaza, Omaha, NE 68178, USA. Electronic address:

Current treatment regimens for non-tuberculous mycobacteria (NTM) and tuberculosis (TB) generally require long duration of therapy with multiple drugs, some of which are broad spectrum antibiotics. Despite some advances in antimicrobial compounds, there remains a need in therapy for antibiotics with specific mycobacterial targets. It has been shown that MmpL3 is an essential transporter required for the translocation of mycolic acids to the mycobacterial cell envelope. Read More

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http://dx.doi.org/10.1016/j.bmc.2017.05.015DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5539987PMC
July 2017
66 Reads

Expression, purification, and characterization of recombinant 8 kDa gelsolin fragment.

Protein Expr Purif 2017 Jul 29;135:33-36. Epub 2017 Apr 29.

The State Key Laboratory of Pharmaceutical Biotechnology, School of Life Sciences, Nanjing University, Nanjing, Jiangsu, 163 Xianlin Avenue, 210046, China; Changzhou High-Tech Research Institute of Nanjing University and Jiangsu Target Pharma Laboratories Inc., Changzhou, Jiangsu, 213164, China. Electronic address:

A mutation (D187N/Y) in human plasma gelsolin (GSN) leads to the generation of an 8 kDa GSN fragment (8 kDa-GSN), and consequently causes the familial amyloidosis of Finnish type. Because of its faster kinetics of amyloid formation under physiologically relevant conditions, 8 kDa-GSN is used to explore gelsolin amyloidosis and screen small molecules that can disaggregate amyloids. However, the synthetic 8 kDa-GSN is expensive, and substantial quantities of 8 kDa-GSN are needed for the screen. Read More

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https://linkinghub.elsevier.com/retrieve/pii/S10465928163047
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http://dx.doi.org/10.1016/j.pep.2017.04.016DOI Listing
July 2017
21 Reads

Microbiological and Clinical Outcomes of Treating Non-Mycobacterium Avium Complex Nontuberculous Mycobacterial Pulmonary Disease: A Systematic Review and Meta-Analysis.

Chest 2017 07 28;152(1):120-142. Epub 2017 Apr 28.

Institute for Health Service Research in Dermatology and Nursing, University Medical Center Hamburg-Eppendorf, Hamburg, Germany; Institution for Statutory Accident Insurance and Prevention in the Health and Welfare Services (BGW), Hamburg, Germany.

Background: Pulmonary disease caused by nontuberculous mycobacteria (NTM) is steadily increasing worldwide.

Methods: A systematic review of non-Mycobacterium avium complex studies published prior to October 2016 was conducted with respect to microbiological and clinical outcomes of current treatment regimens.

Results: We retrieved 352 citations, which yielded 24 studies eligible for evaluation. Read More

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http://dx.doi.org/10.1016/j.chest.2017.04.166DOI Listing
July 2017
34 Reads

The volatile molecule signature of four mycobacteria species.

J Breath Res 2017 Jun 29;11(3):031002. Epub 2017 Jun 29.

Thayer School of Engineering, Dartmouth College, 14 Engineering Drive, Hanover, NH 03755, United States of America.

Mycobacteria are the leading cause of death from infectious disease worldwide and limitations in current diagnostics are hampering control efforts. In recent years, the use of small volatile molecules as diagnostic biomarkers for mycobacteria has shown promise for use in the rapid analysis of in vitro cultures as well as ex vivo diagnosis using breath or sputum. In this study, 18 strains from four mycobacteria species (Mycobacterium avium, M. Read More

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http://stacks.iop.org/1752-7163/11/i=3/a=031002?key=crossref
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http://dx.doi.org/10.1088/1752-7163/aa6e06DOI Listing
June 2017
17 Reads

Structure of the mycobacterial ESX-5 type VII secretion system membrane complex by single-particle analysis.

Nat Microbiol 2017 Apr 10;2:17047. Epub 2017 Apr 10.

Vrije Universiteit Amsterdam, De Boelelaan 1108, 1081 HZ Amsterdam, The Netherlands.

Mycobacteria are characterized by their impermeable outer membrane, which is rich in mycolic acids. To transport substrates across this complex cell envelope, mycobacteria rely on type VII (also known as ESX) secretion systems. In Mycobacterium tuberculosis, these ESX systems are essential for growth and full virulence and therefore represent an attractive target for anti-tuberculosis drugs. Read More

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http://dx.doi.org/10.1038/nmicrobiol.2017.47DOI Listing
April 2017
18 Reads

Species-Specific Risk Factors, Treatment Decisions, and Clinical Outcomes for Laboratory Isolates of Less Common Nontuberculous Mycobacteria in Washington State.

Ann Am Thorac Soc 2017 Jul;14(7):1129-1138

1 Department of Medicine, School of Medicine and.

Rationale: Nontuberculous mycobacteria (NTM) are a diverse group of environmental organisms that infrequently cause human disease. Understanding of the epidemiologic and clinical characteristics associated with NTM disease is needed to refine diagnostic and treatment strategies, particularly among the less commonly isolated species.

Objectives: To improve knowledge of geographic variance of NTM species, to correlate detailed clinical information with isolation of specific NTM, and to examine the decision to treat and outcomes for specific NTM. Read More

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http://dx.doi.org/10.1513/AnnalsATS.201609-731OCDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5566289PMC
July 2017
21 Reads

[Distribution and drug resistance of nontuberculous in Beijing].

Zhonghua Jie He He Hu Xi Za Zhi 2017 Mar;40(3):210-214

Central Laboratory of Beijing Research Institute for Tuberculosis Control, Beijing 100035, China.

To analyze the distribution and drug resistance of nontuberculous mycobacteria(NTM) in Beijing. Using PCR-fluorescence probe method we identified 1 552 mycobacterial isolates in 2009 and 1 553 mycobacterial isolates in 2013, which were stored by Beijing Research Institute for Tuberculosis Control.All identified NTM strains were confirmed by 16S rRNA gene sequencing, and drug sensitivity testing was performed by using 1% ratio method. Read More

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http://dx.doi.org/10.3760/cma.j.issn.1001-0939.2017.03.013DOI Listing
March 2017
14 Reads

Pulmonary Nontuberculous Mycobacteria-Associated Deaths, Ontario, Canada, 2001-2013.

Emerg Infect Dis 2017 03;23(3):468-476

Survival implications of nontuberculous mycobacterial pulmonary disease (NTM-PD) and NTM pulmonary isolation without disease (NTM-PI) are unclear. To study deaths associated with NTM-PD and NTM-PI and differences in survival between them, we conducted a population-based cohort study of persons with microbiologically defined NTM-PD or NTM-PI diagnosed during 2001-2013 in Ontario, Canada. We used propensity score matching and Cox proportional hazards models to compare survival. Read More

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http://dx.doi.org/10.3201/eid2303.161927DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5382758PMC
March 2017
25 Reads

Nontuberculous Mycobacterial Infections in a French Hospital: A 12-Year Retrospective Study.

PLoS One 2016 13;11(12):e0168290. Epub 2016 Dec 13.

Service de maladies infectieuses et tropicales, Centre Hospitalier Universitaire de Bordeaux, Bordeaux, France.

Background: Nontuberculous mycobacteria (NTM) are environmental organisms associated with a range of infections. Reports of NTM epidemiology are mainly focused on pulmonary infections and isolations, and extrapulmonary infections are less frequently described.

Methods: We conducted a retrospective study of NTM infections at the Bordeaux University Hospital, France, between January 2002 and December 2013. Read More

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http://journals.plos.org/plosone/article?id=10.1371/journal.pone.0168290PLOS
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5154556PMC
July 2017
42 Reads

Other Slow-Growing Nontuberculous Mycobacteria.

Microbiol Spectr 2016 11;4(6)

Infectious Diseases Section, VA Medical Center, Omaha, NE 68105.

The list of clinically important slow-growing nontuberculous mycobacteria (NTM) continues to expand as new species are identified and older ones are found to be pathogenic. Based on pigment production, the strains may be classified as photochromogenic, scotochromogenic, or unpigmented. Some of these organisms are not newly discovered but have heretofore been considered virtually nonpathogenic. Read More

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http://dx.doi.org/10.1128/microbiolspec.TNMI7-0012-2016DOI Listing
November 2016
13 Reads

Factors which influence treatment initiation for pulmonary non-tuberculous mycobacterium infection in HIV negative patients; a multicentre observational study.

Respir Med 2016 11 6;120:101-108. Epub 2016 Oct 6.

London North West Healthcare NHS Trusts, London, UK.

Background: Clinical, radiological and microbiological criteria inform diagnosis of pulmonary Non-Tuberculous Mycobacteria (NTM) disease and treatment decisions. This multicentre, review aims to characterise NTM disease meeting ATS/IDSA criteria and define factors associated with initiation of treatment.

Methods: Sputum samples growing NTM from 5 London hospitals between 2010 and 2014 were identified. Read More

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http://dx.doi.org/10.1016/j.rmed.2016.10.001DOI Listing
November 2016
45 Reads

Non-tuberculous mycobacteria: epidemiological pattern in a reference laboratory and risk factors associated with pulmonary disease.

Epidemiol Infect 2017 02 2;145(3):515-522. Epub 2016 Nov 2.

Unit of Infectious and Tropical Diseases,Careggi Hospital,Florence,Italy.

The diseases caused by non-tuberculous mycobacteria (NTM), in both AIDS and non-AIDS populations, are increasingly recognized worldwide. Although the American Thoracic Society published the guidelines for diagnosis of NTM pulmonary disease (NTM-PD), the diagnosis is still difficult. In the first part of the study, we collected data on NTM isolates in the Mycobacteriology Laboratory of Careggi Hospital (Florence, Italy) and analysed the epidemiological data of NTM isolates. Read More

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http://search.proquest.com/openview/05453e28d5bbc06e2b65cda6
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https://www.cambridge.org/core/services/aop-cambridge-core/c
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http://dx.doi.org/10.1017/S0950268816002521DOI Listing
February 2017
8 Reads

Comparison of MALDI-TOF MS, nucleic acid hybridization and the MPT64 immunochromatographic test for the identification of M. tuberculosis and non-tuberculosis Mycobacterium species.

New Microbiol 2016 Oct 23;39(4):259-263. Epub 2016 Aug 23.

Marmara University, Faculty of Medicine, Department of Medical Microbiology, Istanbul, Turkey.

Mycobacteria are an important cause of morbidity in humans. Rapid and accurate mycobacterial identification is important for improving patient outcomes. However, identification of Mycobacterium species is not easy, due to the slow and fastidious growth of mycobacteria. Read More

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October 2016
16 Reads

Miliary pulmonary nodules due to Mycobacterium xenopi in a steroid-induced immunocompromised patient successfully treated with chemotherapy: a case report.

BMC Pulm Med 2016 Jun 10;16(1):92. Epub 2016 Jun 10.

Division of Pulmonary Medicine, National Hospital Organization Kochi Hospital, 1-2-25 Asakuranishimachi, Kochi, 780-8077, Japan.

Background: Mycobacterium xenopi-infected patients have a high prevalence of pulmonary cavities and nodules. However, the clinical course for patients with miliary nodules due to M. xenopi has not yet been reported. Read More

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http://dx.doi.org/10.1186/s12890-016-0252-yDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4902965PMC
June 2016
36 Reads

Pulmonary Disease Caused by Non-Tuberculous Mycobacteria.

Respiration 2016 21;91(5):386-402. Epub 2016 May 21.

Division of Clinical Infectious Diseases, Research Center Borstel, Borstel, Germany.

Non-tuberculous mycobacteria (NTM) include more than 160 ubiquitous, environmental, acid-fast-staining bacterial species, some of which may cause disease in humans. Chronic pulmonary infection is the most common clinical manifestation. Although patients suffering from chronic lung diseases are particularly susceptible to NTM pulmonary disease, many affected patients have no apparent risk factors. Read More

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http://dx.doi.org/10.1159/000445906DOI Listing
August 2017
32 Reads

Vertebral osteomyelitis caused by non-tuberculous mycobacteria: Predisposing conditions and clinical characteristics of six cases and a review of 63 cases in the literature.

Infect Dis (Lond) 2016 Jul 22;48(7):509-16. Epub 2016 Mar 22.

a Department of Internal Medicine , Seoul National University College of Medicine , Seoul , Republic of Korea ;

Background Several case series have reported on clinical and radiographic characteristics of patients with vertebral osteomyelitis (VO) caused by non-tuberculous mycobacteria (NTM). However, only a few patients were included, and systematic reviews are still lacking. The aim of this study was to update and summarise the pre-disposing conditions, clinical and radiographic characteristics of such cases due to NTM. Read More

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http://dx.doi.org/10.3109/23744235.2016.1158418DOI Listing
July 2016
18 Reads

Update on pulmonary disease due to non-tuberculous mycobacteria.

Int J Infect Dis 2016 Apr 11;45:123-34. Epub 2016 Mar 11.

Stanley Ho Centre for Emerging Infectious Diseases, The Chinese University of Hong Kong, Hong Kong, China.

Non-tuberculous mycobacteria (NTM) are emerging worldwide as significant causes of chronic pulmonary infection, posing a number of challenges for both clinicians and researchers. While a number of studies worldwide have described an increasing prevalence of NTM pulmonary disease over time, population-based data are relatively sparse and subject to ascertainment bias. Furthermore, the disease is geographically heterogeneous. Read More

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https://linkinghub.elsevier.com/retrieve/pii/S12019712163099
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http://dx.doi.org/10.1016/j.ijid.2016.03.006DOI Listing
April 2016
7 Reads