2,056 results match your criteria Mycobacterium Kansasii

Alkaloids of (Papaveraceae) and Berberine Derivatives as a New Class of Antimycobacterial Agents.

Biomolecules 2022 Jun 17;12(6). Epub 2022 Jun 17.

ADINACO Research Group, Department of Pharmacognosy and Pharmaceutical Botany, Faculty of Pharmacy, Charles University, Heyrovskeho 1203, 500 05 Hradec Kralove, Czech Republic.

Tuberculosis (TB) is a widespread infectious disease caused by . The increasing incidence of multidrug-resistant (MDR) and extensively drug-resistant (XDR) strains has created a need for new antiTB agents with new chemical scaffolds to combat the disease. Thus, the key question is: how to search for new antiTB and where to look for them? One of the possibilities is to search among natural products (NPs). Read More

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activity of fidaxomicin against nontuberculosis mycobacteria.

J Med Microbiol 2022 Jun;71(6)

College of Veterinary Medicine, China Agricultural University, Beijing, PR China.

Nontuberculous mycobacteria (NTM) infections are increasing worldwide and are relatively resistant to many of the first- and second-line drugs to treat tuberculosis. Macrolide antibiotics, such as clarithromycin and azithromycin, are the key drugs for treating NTM infections. Fidaxomicin is a macrolide antibiotic that is widely used in treating infections, and has high activity against especially multidrug-resistant tuberculosis (MDR-TB) and has no cross-resistance with rifampicin. Read More

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Alere Determine-tuberculosis lipoarabinomannan positivity in disseminated non-tuberculous mycobacteria: An illustrative case series.

South Afr J HIV Med 2022 4;23(1):1369. Epub 2022 Apr 4.

Department of Medicine, Faculty of Health Sciences, University of Cape Town, Cape Town, South Africa.

Introduction: In outpatients, the World Health Organization recommends that the urine Alere Determine-tuberculosis lipoarabinomannan (AlereLAM) should be used to support the diagnosis of tuberculosis (TB) in people living with HIV (PLHIV) with CD4 counts ≤ 100 cells/µL or with signs of being 'seriously ill'. There is a risk of a false-positive AlereLAM in disseminated non-tuberculous mycobacterial (NTM) infections and it may be difficult to differentiate a single infection (either or NTM) from dual infection.

Patient Presentation: We report three patients, enrolled in an operational study assessing AlereLAM use in an outpatient setting, who had advanced HIV (all CD4 < 20 cells/µL) and strongly positive (grade 4+) AlereLAM results in whom Mycobacterium avium or kansasii were later cultured from blood or urine and sputum. Read More

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Post Surgical Non-tuberculous Mycobacterium: A Case Series.

Cureus 2022 May 3;14(5):e24701. Epub 2022 May 3.

Department of Medicine, Government Medical College, Aurangabad, IND.

Background There has been an increase in non-tuberculous mycobacteria (NTM) infection reports in humans. Surgeons are concerned about the link between them and surgical site infections. As a result, it has been challenging to determine just how common this illness is. Read More

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Non-tuberculous mycobacterial thoracic osteomyelitis in an immunocompetent host: a rare presentation of .

BMJ Case Rep 2022 May 26;15(5). Epub 2022 May 26.

Department of Infectious Diseases, The University of Iowa Hospitals and Clinics, Iowa City, Iowa, USA.

An immunocompetent man in his 40s presented with 3 months of mid-thoracic back pain which progressed to include progressive paraesthesias and lower extremity weakness. Investigations revealed thoracic spine osteomyelitis with signs of cord compression. He underwent neurosurgical intervention, including laminectomy, spinal cord decompression and partial resection of an epidural mass. Read More

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Mycobacterium avium complex infected cells promote growth of the pathogen Pseudomonas aeruginosa.

Microb Pathog 2022 May 22;166:105549. Epub 2022 Apr 22.

Unidad de Investigación, Complejo Asistencial Universitario de León, Gerencia Regional de Salud de Castilla y León (SACYL), Altos de Nava, s/n, 24071, León, Spain; Institute of Biomedical Research of Salamanca (IBSAL), Spain; Institute of Biomedicine, University of León, León, Spain. Electronic address:

Bronchiectasis is considered a consequence of the neutrophilic inflammatory response to infection. Mycobacterial infections, mainly from the Mycobacterium avium complex and M. abscessus, have been inextricably linked to bronchiectasis development. Read More

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Infection of a Free-Living Wild Boar () with a Bacterium from the Complex.

Animals (Basel) 2022 Apr 8;12(8). Epub 2022 Apr 8.

National Veterinary Research Institute, 24-100 Puławy, Poland.

The most numerous group of bacteria in the genus is the nontuberculous mycobacteria. Currently, over 200 species of bacteria have been classified as belonging to this group, of which approximately 30 are pathogenic to humans and animals. complex numbers among these pathogenic species. Read More

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Simultaneous detection of Mycobacterium tuberculosis and atypical mycobacteria by DNA-Microarray in Egypt.

Med Princ Pract 2022 Apr 12. Epub 2022 Apr 12.

Background And Objectives: Immunocompromised patients are considered a high-risk group to develop mycobacterial infections with either pulmonary and/or extra-pulmonary diseases. Low-cost and low-density (LCD) DNA-microarray is considered an easy and efficient method to detect typical and atypical Mycobacterial species.

Materials And Methods: Thirty immunocompromised patients were recruited to provide their clinical specimens (sputum, serum, urine and lymph node aspirate). Read More

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Prosthetic Knee Joint Infection Caused by Mycobacterium kansasii.

J Am Acad Orthop Surg Glob Res Rev 2022 04 7;6(4). Epub 2022 Apr 7.

From the Department of Orthopaedic Surgery at the Medical College of Wisconsin, Wauwatosa, WI (Mr. Dasari, Dr. Hadro, and Dr. Neilson), and the Department of Pathology at the Medical College of Wisconsin, Wauwatosa, WI (Dr. Singh).

Mycobacterium kansasii is a nontuberculous mycobacterium that is a rare cause of prosthetic joint infections (PJIs). This case report presents a 58-year-old man who developed rapidly progressive arthritis after exposing his right knee to an unknown fluid at a microbial pharmaceutical company. Within a year, he underwent a right total knee arthroplasty (TKA). Read More

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Antibacterial Activity of Isobavachalcone (IBC) Is Associated with Membrane Disruption.

Membranes (Basel) 2022 Feb 25;12(3). Epub 2022 Feb 25.

Department of Chemistry and Environmental Sciences, Institute of Biosciences, Humanities and Exact Sciences, São Paulo State University (Unesp), São José do Rio Preto 15054-000, SP, Brazil.

Isobavachalcone () is a natural prenylated chalcone with a broad spectrum of pharmacological properties. In this work, we newly synthesized and investigated the antibacterial activity of against Gram-positive, Gram-negative and mycobacterial species. was active against Gram-positive bacteria, mainly against Methicillin-Susceptible (MSSA) and Methicillin-Resistant (MRSA), with minimum inhibitory concentration (MIC) values of 1. Read More

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February 2022

Rifampin Pharmacokinetics/Pharmacodynamics in the Hollow-Fiber Model of Mycobacterium kansasii Infection.

Antimicrob Agents Chemother 2022 04 22;66(4):e0232021. Epub 2022 Mar 22.

Division of Infectious Diseases and International Health, University of Virginia, Charlottesville, Virginia, USA.

There is limited high-quality evidence to guide the optimal treatment of Mycobacterium kansasii pulmonary disease. We retrospectively collected clinical data from 33 patients with M. kansasii pulmonary disease to determine the time-to-sputum culture conversion (SCC) upon treatment with a standard combination regimen consist of isoniazid-rifampin-ethambutol. Read More

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Ethambutol-induced bullous skin lesions in lung infection.

Int J Mycobacteriol 2022 Jan-Mar;11(1):120-122

Salem VA Medical Center, Salem, VA; Virginia Tech Carilion School of Medicine, Roanoke, Virginia; Department of Infectious Disease, Salem VA Medical Center, Salem, VA, USA.

Mycobacterium kansasii is the second most common cause of nontuberculous mycobacterial (NTM) lung disease after Mycobacterium avium complex infection in the United States. The first-line therapy for M. kansasii is a three-drug regimen including rifampin, isoniazid, and ethambutol. Read More

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Distribution of nontuberculous mycobacteria in patients with and without HIV/AIDS in Chongqing.

HIV Med 2022 03;23 Suppl 1:54-63

Guangzhou Eighth People's Hospital, Guangzhou Medical University, Guangzhou, China.

Introduction: In this study, the distribution of nontuberculous mycobacteria (NTM) strains in patients with and without HIV/AIDS in Chongqing, China was evaluated.

Methods: A retrospective study was performed in January-December 2020 at Chongqing Public Health Medical Center. NTM strains were assessed by a multi locus phylogenetic analysis. Read More

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Identification and characterization of nontuberculous mycobacteria isolated from suspected pulmonary tuberculosis patients in eastern china from 2009 to 2019 using an identification array system.

Braz J Infect Dis 2022 Mar-Apr;26(2):102346. Epub 2022 Mar 11.

Department of Infectious Diseases, Shanghai Key Laboratory of Infectious Diseases and Biosafety Emergency Response, National Medical Center for Infectious Diseases, Huashan Hospital, Fudan University, Shanghai, China. Electronic address:

Objective: Nontuberculous mycobacteria (NTM) species are increasingly being isolated and have become a key factor affecting public health by causing pulmonary diseases. Most NTM species do not respond to conventional tuberculosis (TB) drugs. This study aimed to identify NTM isolated from suspected pulmonary TB patients from the Zhejiang province and analyze their distribution in the region. Read More

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Drug resistance profiles and related gene mutations in slow-growing non-tuberculous mycobacteria isolated in regional tuberculosis reference laboratories of Iran: a three year cross-sectional study.

Pathog Glob Health 2022 Mar 9:1-11. Epub 2022 Mar 9.

Infectious and Tropical Diseases Research Center, Health Research Institute, Ahvaz Jundishapur University of Medical Sciences, Ahvaz, Iran.

There are limited studies on the antibiotic resistance patterns of slowly growing mycobacteria (SGM) species and their related gene mutations in Iran. This study aimed to elucidate the antibiotic susceptibility profiles and the mutations in some genes that are associated with the antibiotic resistance among SGM isolates from Iran. The SGM strains were isolated from sputum samples of suspected tuberculosis (TB) patients. Read More

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Factors Associated with Treatment Outcome in Patients with Nontuberculous Mycobacterial Pulmonary Disease: A Large Population-Based Retrospective Cohort Study in Shanghai.

Trop Med Infect Dis 2022 Feb 15;7(2). Epub 2022 Feb 15.

Clinical and Research Center for Tuberculosis, Shanghai Key Laboratory of Tuberculosis, Shanghai Pulmonary Hospital, School of Medicine, Tongji University, Shanghai 200433, China.

Infectious diseases caused by nontuberculous mycobacteria (NTM) are increasingly common. This retrospective cohort study examined factors associated with outcomes in patients from Shanghai who had NTM pulmonary disease (NTMPD) from January 2014 to December 2018. The causative bacterial species, drug susceptibility test results, treatment outcomes, sputum culture conversion rate, and risk factors associated with treatment failure were determined. Read More

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February 2022

Pleural Effusion/Empyema With Mycobacterium kansasii.

Cureus 2022 Jan 16;14(1):e21300. Epub 2022 Jan 16.

Infectious Diseases, The University of Toledo, Toledo, USA.

is a nontuberculous mycobacterium that causes pulmonary symptoms, commonly associated with underlying conditions, including malignancy, prior transplant, and HIV. However, rarely does present with pleural effusion. We present a case of a 56-year-old female who presented with dyspnea and chest pain, and sputum culture was positive for acid-fast bacilli. Read More

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January 2022

Epidemiological profile and follow-up of patients with pulmonary disease by non-tuberculous mycobacteria in Baixada Santista area, São Paulo.

Einstein (Sao Paulo) 2022 14;20:eAO5510. Epub 2022 Feb 14.

Instituto Adolfo Lutz, Santos, SP, Brazil.

Objective: To present the frequency and species diversity of non-tuberculous mycobacteria, estimate the prevalence of non-tuberculous mycobacterial pulmonary disease, describe the epidemiological profile, and determine the follow-up of patients with non-tuberculous mycobacterial pulmonary disease living in a region with a high burden of tuberculosis.

Methods: This a retrospective cohort observational study using data records obtained from the Instituto Adolfo Lutz - Santos and from the São Paulo Sistema de Vigilância de Tuberculose do Estado de São Paulo in the period between 2000 and 2009. The studied variables were: socio-demographic characteristics, current and past history of tuberculosis, aspects related to diagnosis, and treatment and associated diseases. Read More

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February 2022

The hemerythrin-like diiron protein from Mycobacterium kansasii is a nitric oxide peroxidase.

J Biol Chem 2022 03 10;298(3):101696. Epub 2022 Feb 10.

Burnett School of Biomedical Sciences, College of Medicine, University of Central Florida, Orlando, Florida, USA. Electronic address:

The hemerythrin-like protein from Mycobacterium kansasii (Mka HLP) is a member of a distinct class of oxo-bridged diiron proteins that are found only in mycobacterial species that cause respiratory disorders in humans. Because it had been shown to exhibit weak catalase activity and a change in absorbance on exposure to nitric oxide (NO), the reactivity of Mka HLP toward NO was examined under a variety of conditions. Under anaerobic conditions, we found that NO was converted to nitrite (NO) via an intermediate, which absorbed light at 520 nm. Read More

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Consensus management recommendations for less common non-tuberculous mycobacterial pulmonary diseases.

Lancet Infect Dis 2022 Jul 25;22(7):e178-e190. Epub 2022 Jan 25.

National Jewish Health and University of Colorado Health Sciences, Denver, CO, USA.

The 2020 clinical practice guideline for the treatment of non-tuberculous mycobacterial pulmonary disease (NTM-PD) by the American Thoracic Society, European Respiratory Society, European Society of Clinical Microbiology and Infectious Diseases, and Infectious Diseases Society of America; and the 2017 management guideline by the British Thoracic Society covered pulmonary diseases in adults caused by Mycobacterium avium complex, Mycobacterium kansasii, Mycobacterium xenopi, and Mycobacterium abscessus. In order to provide evidence-based recommendations for the treatment of less common non-tuberculous mycobacterial (NTM) species in adult patients without cystic fibrosis or HIV infection, our expert panel group performed systematic literature searches to provide management guidance for pulmonary diseases caused by seven additional organisms: Mycobacterium chelonae, Mycobacterium fortuitum, Mycobacterium genavense, Mycobacterium gordonae, Mycobacterium malmoense, Mycobacterium simiae, and Mycobacterium szulgai. Treatment recommendations were developed by a structured consensus process. Read More

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infection in a psoriasis patient treated with adalimumab and switch to apremilast: First report and literature review.

Dermatol Reports 2021 Nov 29;13(3):8797. Epub 2021 Jul 29.

Department of Dermatology.

Patient under anti-TNF-alpha treatment have an increased risk of mycobacterial infections, particularly tuberculosis. Only four case reports of infection under anti-TNF-α treatment (two with etanercept, two with infliximab) have been reported, but none under adalimumab. A 72-year-old man treated with adalimumab for psoriasis vulgaris and arthropathic psoriasis, complained on nocturnal cough, occasional hemoptysis and the new onset of ill-defined, reddish, asymptomatic persistent plaques-nodules covered by serum crusts on his back, on the dorsum of the right hand and right middle finger. Read More

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November 2021

Anti-interferon-γ Antibody-seropositive Disseminated Nontuberculous Mycobacterial Infection Mimicking POEMS and TAFRO Syndromes: A Case Report.

Intern Med 2022 Jan 13. Epub 2022 Jan 13.

Department of Hematology and Clinical Immunology, Yokohama City University School of Medicine, Japan.

Disseminated nontuberculous mycobacterial infection (DNTM) is typically observed in immunocompromised hosts. Recently, it has been reported that healthy individuals with serum neutralizing autoantibodies for interferon (IFN)-γ can also develop DNTM. We herein report a case of anti-IFN-γ antibody-seropositive DNTM caused by Mycobacterium kansasii with symptoms mimicking TAFRO or POEMS syndrome, including anasarca, organomegaly, skin pigmentation, polyneuropathy, osteosclerotic change, thrombocytopenia, serum M protein, high C-reactive protein level, and reticulin fibrosis. Read More

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January 2022

Clinical and Microbiological Characteristics of Mycobacterium kansasii Pulmonary Infections in China.

Microbiol Spectr 2022 02 12;10(1):e0147521. Epub 2022 Jan 12.

Department of Clinical Laboratory, Shanghai Pulmonary Hospital, School of Medicine, Tongji University, Shanghai, China.

Mycobacterium kansasii, an important opportunistic pathogen of humans, causes serious pulmonary disease. Sixty M. kansasii isolates were collected for investigating the clinical characteristics of patients with M. Read More

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February 2022

Design and Synthesis of Highly Active Antimycobacterial Mutual Esters of 2-(2-Isonicotinoylhydrazineylidene)propanoic Acid.

Pharmaceuticals (Basel) 2021 Dec 14;14(12). Epub 2021 Dec 14.

Department of Organic and Bioorganic Chemistry, Faculty of Pharmacy in Hradec Králové, Charles University, Akademika Heyrovského 1203, 500 05 Hradec Králové, Czech Republic.

The combination of two active scaffolds into one molecule represents a proven approach in drug design to overcome microbial drug resistance. We designed and synthesized more lipophilic esters of 2-(2-isonicotinoylhydrazineylidene)propanoic acid, obtained from antitubercular drug isoniazid, with various alcohols, phenols and thiols, including several drugs, using carbodiimide-mediated coupling. Nineteen new esters were evaluated as potential antimycobacterial agents against drug-sensitive (. Read More

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December 2021

An overview of drugs for the treatment of Mycobacterium kansasii pulmonary disease.

J Glob Antimicrob Resist 2022 03 18;28:71-77. Epub 2021 Dec 18.

Section of Pulmonary and Critical Care, University of Texas at Tyler, Tyler, Texas, USA.

Objectives: The aim of this study was to determine and compare the efficacy of drugs to treat Mycobacterium kansasii (Mkn) pulmonary disease by performing minimum inhibitory concentration (MIC) determination and time-kill studies.

Methods: We determined the MICs to 13 drugs against the Mkn standard laboratory strain ATCC 12478 and 20 clinical isolates and performed time-kill studies with 18 drugs from different classes using the standard laboratory strain of Mkn. The β-lactam antibiotics were tested with or without the combination of the β-lactamase inhibitor avibactam. Read More

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Hypercalcaemia in pulmonary infection.

BMJ Case Rep 2021 Nov 30;14(11). Epub 2021 Nov 30.

Nephrology and Hypertension, Miami Transplant Institute, Miami, Florida, USA.

A gentleman in his 60s with end-stage kidney disease status post kidney transplantation on prednisone and tacrolimus presented with generalised weakness for 7 days, associated with altered mental status. Investigations revealed pancytopenia, acute kidney injury, hypercalcaemia, decreased parathyroid hormone (PTH) and normal calcitriol levels. CT of the chest showed multifocal lung opacities suspicious for malignancy. Read More

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November 2021

Recombinant BCG-Prime and DNA-Boost Immunization Confers Mice with Enhanced Protection against .

Vaccines (Basel) 2021 Nov 1;9(11). Epub 2021 Nov 1.

Department of Pathology and Microbiology, Division of Microbiology, Nihon University School of Medicine, Tokyo 173-8610, Japan.

The incidence of infections with nontuberculous mycobacteria (NTM) has been increasing worldwide. The emergence of multidrug-resistant NTM is a serious clinical concern, and a vaccine for NTM has not yet been developed. We previously developed a new recombinant Bacillus Calmette-Guérin (rBCG) vaccine encoding the antigen 85B (Ag85B) protein of -termed rBCG-Mkan85B-which was used together with a booster immunization with plasmid DNA expressing the same Ag85B gene (DNA-Mkan85B). Read More

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November 2021

Drug susceptibility profiling of pulmonary and its correlation with treatment outcome.

Ann Thorac Med 2021 Oct-Dec;16(4):323-328. Epub 2021 Oct 26.

Department of Bacteriology, ICMR -National Institute for Research in Tuberculosis, Chennai, Tamil Nadu, India.

Objectives: With the introduction of newer molecular diagnostic tools to identify , an increasing number of nontuberculous mycobacterium (NTM) is being identified. However, the drug resistance pattern of the NTM species identified is less explored. The objective of this study is to study the drug resistance patterns of species isolated in a tuberculosis-endemic setting at South India. Read More

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October 2021

Intradermal comparative cervical tuberculin test in the diagnosis of caprine tuberculosis.

Braz J Microbiol 2022 Mar 12;53(1):421-431. Epub 2021 Nov 12.

Department of Preventive Veterinary Medicine and Animal Science, USP, São Paulo, SP, Brazil.

Tuberculosis remains one of the most important infectious diseases with well-known zoonotic nature that affect humans, wildlife, and domestic animals, including goats. Nonetheless, no intradermal tuberculin test has been standardized for caprine diagnosis of tuberculosis. The present study investigated the intradermal comparative cervical tuberculin test (ICCTT) in the diagnosis of tuberculosis among 60 goats from farms with history of tuberculosis. Read More

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