2,005 results match your criteria Mycobacterium Kansasii


Bronchial Brushing and Diagnosis of Pulmonary Nontuberculous Mycobacteria Infection.

Respiration 2021 May 27:1-9. Epub 2021 May 27.

Department of Respiratory Medicine, Toho University Omori Medical Center, Tokyo, Japan.

Background: The optimal bronchoscopy procedure for diagnosis of pulmonary nontuberculous mycobacteria (NTM) infection is unclear.

Objective: This study investigated the usefulness of bronchial brushing in bronchoscopy for diagnosis of pulmonary NTM infection in patients with suspected NTM lung disease and nodular bronchiectasis on chest computed tomography (CT) images.

Methods: Bronchoscopy was prospectively performed for 69 patients with clinically suspected pulmonary NTM infection on chest CT from December 2017 through December 2019. Read More

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Comparative cellular immune responses in calves after infection with Mycobacterium avium subsp. paratuberculosis, M. avium subsp. avium, M. kansasii and M. bovis.

Vet Immunol Immunopathol 2021 Jul 19;237:110268. Epub 2021 May 19.

USDA-ARS, National Animal Disease Center, Ames, IA 50010, United States.

In the present study, calves were infected with Mycobacterium avium subsp. paratuberculosis (MAP), Mycobacterium avium subsp. avium (M. Read More

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Combining comparative genomic analysis with machine learning reveals some promising diagnostic markers to identify five common pathogenic non-tuberculous mycobacteria.

Microb Biotechnol 2021 May 21. Epub 2021 May 21.

CAS Key Laboratory of Genome Sciences & Information, China National Center for Bioinformation, Chinese Academy of Sciences, Beijing Institute of Genomics, Beijing, 100101, China.

Non-tuberculous mycobacteria (NTM) can cause various respiratory diseases and even death in severe cases, and its incidence has increased rapidly worldwide. To date, it's difficult to use routine diagnostic methods and strain identification to precisely diagnose various types of NTM infections. We combined systematic comparative genomics with machine learning to select new diagnostic markers for precisely identifying five common pathogenic NTMs (Mycobacterium kansasii, Mycobacterium avium, Mycobacterium intracellular, Mycobacterium chelonae, Mycobacterium abscessus). Read More

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Use of saline to evaluate a cavity due to infection during ultrathin bronchoscopy and endobronchial ultrasonography.

Respirol Case Rep 2021 Jun 10;9(6):e00766. Epub 2021 May 10.

Department of Internal Medicine, Division of Medical Oncology & Respiratory Medicine Shimane University Shimane Japan.

A 28-year-old man had a cavitary lesion in the upper right lobe with a tree-in-bud appearance on chest computed tomography (CT). Diagnostic bronchoscopy was performed. An ultrathin bronchoscope in the right B2aiiβxyy reached the cavity. Read More

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Simultaneous Onset of Mycobacterium kansasii Pulmonary Infection and Systemic Lupus Erythematosus: A Case Report.

Am J Case Rep 2021 May 19;22:e929866. Epub 2021 May 19.

Division of Rheumatology, Università Cattolica del Sacro Cuore, Rome, Italy.

BACKGROUND Systemic lupus erythematosus (SLE) is a systemic autoimmune disease resulting from dysregulation of the immune response. In genetically predisposed subjects, infections reputedly trigger an immune activation leading to autoimmunity and overt autoimmune diseases such as SLE. CASE REPORT We report the case of a 19-year-old woman who presented to our hospital reporting high-grade fever, dry cough, and polyarthralgia despite a course of empiric antibiotic and steroid therapy administered by her general practitioner (GP). Read More

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Population genomics provides insights into the evolution and adaptation to humans of the waterborne pathogen Mycobacterium kansasii.

Nat Commun 2021 05 3;12(1):2491. Epub 2021 May 3.

Shanghai Institute of Infectious Disease and Biosecurity, Key Laboratory of Medical Molecular Virology (MOE/NHC/CAMS), Shanghai Medical College and School of Basic Medical Sciences, Shanghai Public Health Clinical Center, Fudan University, Shanghai, China.

Mycobacterium kansasii can cause serious pulmonary disease. It belongs to a group of closely-related species of non-tuberculous mycobacteria known as the M. kansasii complex (MKC). Read More

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Nontuberculous mycobacteria in China: incidence and antimicrobial resistance spectrum from a nationwide survey.

Infect Dis Poverty 2021 Apr 29;10(1):59. Epub 2021 Apr 29.

National Center for Tuberculosis Control and Prevention, Chinese Center for Disease Control and Prevention, Changbai Road 155, Changping, Beijing102206, China.

Background: Information on the prevalence and resistance spectrum of nontuberculous mycobacteria (NTM) in China is mainly based on regional or local data. To estimate the proportion of NTM cases in China, a national survey of NTM pulmonary disease was carried out based on acid-fast positive sputum samples collected in 2013.

Methods: Sputum samples collected from enrolled presumptive cases in 72 nationwide tuberculosis surveillance sites from the 31 provinces in the mainland of China were cultured using L-J medium at the National tuberculosis reference laboratory (NTRL). Read More

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Identification and Characteristics of Co-isolation of Multiple Nontuberculous Mycobacteria.

Intern Med 2021 Apr 26. Epub 2021 Apr 26.

Division of Pulmonary Medicine, Department of Respiratory Medicine, Kanagawa Cardiovascular and Respiratory Center, Japan.

Objective Although multiple non-tuberculous mycobacteria (NTM) species can be isolated from the same patient, little has been reported on co-isolation. We clarified the trends and characteristics of the co-isolation of multiple NTM species. Methods To collect data on multiple NTM isolation, we first extracted all patients who visited our hospital from 2006 through 2015 with a diagnosis of NTM lung diseases other than Mycobacterium avium complex (MAC) and then reviewed their medical records to evaluate the co-isolation of multiple NTM species. Read More

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Chronic Mycobacterium kansasii tenosynovitis in an immunocompromised host : case report.

Acta Orthop Belg 2020 Dec;86(4):621-623

Mycobacteriuim kansasii is a nontuberculous atypical mycobacterium which typically causes respiratory infections. Localized extrapulmonary diseases, such as tenosynovitis or arthritis are rarely seen in the immunocompetent population (1) . We present a case of an immunocompromised 55-year-old man with a chronic Mycobacteriuim kansasii tenosynovitis of the hand. Read More

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December 2020

Mycobacteria In Skin Lesions and the Habitat of the Endangered Houston Toad (Anaxyrus houstonensis).

J Wildl Dis 2021 Apr 15. Epub 2021 Apr 15.

Texas State University, Department of Biology, 601 University Drive, San Marcos, Texas 78666, USA.

Head-starting of the federally endangered Houston toad (Anaxyrus houstonensis), that is, the release of egg strands, tadpoles, and metamorphic juveniles produced in captivity into the original breeding ponds, requires assessment of potential threats for the transmission of pathogens from captive to free-ranging toads. We used Illumina-based 16S rRNA V3 amplicon sequencing to investigate the community structure of bacteria from skin lesions of captive Houston toad and habitat (pond) samples. Proteobacteria, alone or together with Actinobacteria and, in some samples, Cyanobacteria represented virtually all reads in tissue lesion samples, whereas pond samples were much more diverse, with Acidobacteria, Actinobacteria, Bacteriodetes, Chloroflexi, Cyanobacteria, Firmicutes, Planctomycetes, Proteobacteria, and Verrucomicrobia present with little variation between samples. Read More

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Diagnosing MonoMAC Syndrome in GATA2 Germline Mutated Myelodysplastic Syndrome via Next-Generation Sequencing in a Patient with Refractory and Complex Infection: Case Report and Literature Review.

Infect Drug Resist 2021 6;14:1311-1317. Epub 2021 Apr 6.

Department of Hematology, First Affiliated Hospital of Zhejiang Chinese Medical University, Zhejiang Provincial Hospital of TCM, Hangzhou, Zhejiang Province, People's Republic of China.

Monocytopenia and mycobacterial infection (MonoMAC) syndrome is a rare disease. Herein, we reported a 65-year-old Asian woman, previously diagnosed with myelodysplastic syndrome (MDS), suffering from recurrent pneumonia, intermittent fever, fatigue, and chest tightness lasting for five months. She was ultimately diagnosed with MonoMAC syndrome with () infection and GATA2 mutation through metagenomic generation sequencing (mNGS) of peripheral blood specimen, for which she was given anti-NTM therapy. Read More

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Comparison of Susceptibility of Delafloxacin with Ciprofloxacin, Moxifloxacin, and other Comparator Antimicrobials Against Isolates of Nontuberculous Mycobacteria.

Antimicrob Agents Chemother 2021 Apr 12. Epub 2021 Apr 12.

The University of Texas Health Science Center at Tyler, Mycobacteria/Nocardia Laboratory, 11937 U.S. Hwy. 271, Tyler Texas 75708.

Nontuberculous mycobacteria (NTM) infections are increasing globally. complex (MAC) and complex are the most commonly reported NTM. Oral treatment options are limited, especially for the We tested delafloxacin, a new oral fluoroquinolone, against 131 isolates of NTM. Read More

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Clinical Aspects of Pulmonary Nontuberculous Mycobacteriosis.

Intern Med 2021 Apr 12. Epub 2021 Apr 12.

Department of Respiratory Medicine and Infectious Diseases, Niigata University Graduate School of Medical and Dental Science, Japan.

Nontuberculous mycobacterial (NTM) infections are an emerging problem. Common organisms include Mycobacterium avium, M. intracellulare, and M. Read More

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Determination of Clinical Characteristics of -Derived Species by Reanalysis of Isolates Formerly Reported as .

Ann Lab Med 2021 Sep;41(5):463-468

Department of Laboratory Medicine, Seoul National University Hospital, Seoul, Korea.

Background: Seven genotypic subtypes of were recently demonstrated to represent distinct species based on phylogenomic analysis. sensu stricto (formerly known as subtype 1) is most frequently associated with human diseases; only a few studies have compared the diverse clinical characteristics of subtypes, including their drug susceptibilities. We determined the actual incidence of infections caused by each subtype of and identified their clinical characteristics. Read More

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September 2021

PCR-reverse blot hybridization assay in respiratory specimens for rapid detection and differentiation of mycobacteria in HIV-negative population.

BMC Infect Dis 2021 Mar 16;21(1):264. Epub 2021 Mar 16.

Shanghai Clinic and Research Center of Tuberculosis, Department of Tuberculosis, Shanghai Key Laboratory of Tuberculosis, Shanghai Pulmonary Hospital, Tongji University School of Medicine, No. 507 Zhengmin Road, Shanghai, 200433, China.

Background: Rapid identification of pathogenic Mycobacterium species is critical for a successful treatment. However, traditional method is time-consuming and cannot discriminate isolated non-tuberculosis mycobacteria (NTM) at species level. In the retrospective study, we evaluated the clinical applicability of PCR-reverse blot hybridization assay (PCR-REBA Myco-ID) with clinical specimens for rapid detection and differentiation of mycobacterial species. Read More

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Analysis of pulmonary nodules caused by nontuberculous mycobacteriosis in 101 resected cases: multi-center retrospective study.

J Thorac Dis 2021 Feb;13(2):977-985

Osaka University Graduate School of Medicine, Department of General Thoracic Surgery, Suita-shi, Osaka, Japan.

Background: Solitary pulmonary nodules caused by nontuberculous mycobacteriosis are included as a category of pulmonary nontuberculous mycobacterium disease. Clinical characteristics, treatments and prognosis are not fully known because there are a few related reports.

Methods: This was a multi-center retrospective study of 101 cases diagnosed as solitary nodular type of nontuberculous mycobacteriosis from January 2000 to March 2017 that underwent resection at 9 related facilities belonging to the Thoracic Surgery Study Group of Osaka. Read More

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February 2021

Epidemiological risk factors and the geographical distribution of eight Mycobacterium species.

Authors:
Maura J Donohue

BMC Infect Dis 2021 Mar 12;21(1):258. Epub 2021 Mar 12.

United States Environmental Protection Agency, Office of Research and Development, Center of Environmental Solutions and Emergency Response (CESER), 26 W. Martin Luther King Dr. Mail Stop 587, Cincinnati, OH, 45268, USA.

Background: Nontuberculous mycobacteria (NTM) are environmental bacterium that may cause and/or compound respiratory diseases in humans. There are over a hundred NTM species with varying pathogenicity's Therefore, it is necessary to characterize the populations at risk for each species.

Methods: Demographic (age, sex, and state of residence) and microbiological data from 2014 were extracted from Mississippi, Missouri, and Ohio disease surveillance systems. Read More

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Activity of Rifamycin Derivatives against Nontuberculous Mycobacteria, including Macrolide-/Amikacin-Resistant Clinical Isolates.

Antimicrob Agents Chemother 2021 Mar 8. Epub 2021 Mar 8.

Division of Pulmonary and Critical Care Medicine, Department of Medicine, Samsung Medical Center, Sungkyunkwan University School of Medicine, Seoul, South Korea

We evaluated the activity of rifamycin derivatives, including rifampin, rifapentine, rifaximin, and rifabutin, against clinical nontuberculous mycobacteria (NTM) isolates. Of the rifamycin derivatives, rifabutin showed the lowest MICs against all NTM species, including complex, , and Rifabutin also had effective activity against macrolide- and aminoglycoside-resistant NTM isolates. Rifabutin could be worth considering as a therapeutic option for NTM disease, particularly drug-resistant disease. Read More

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Performance of Interferon-Gamma Release Assays in the Diagnosis of Nontuberculous Mycobacterial Diseases-A Retrospective Survey From 2011 to 2019.

Front Cell Infect Microbiol 2020 18;10:571230. Epub 2021 Feb 18.

Shanghai Clinical Research Center for Tuberculosis, Shanghai Pulmonary Hospital, Tongji University School of Medicine, Shanghai, China.

There is an urgent need for precise diagnosis to distinguish nontuberculous mycobacterial (NTM) diseases from pulmonary tuberculosis (PTB) and other respiratory diseases. The aim of this study is to evaluate the diagnostic performance of Interferon-gamma (IFN-γ) release assays (IGRAs), including antigen-specific peripheral blood-based quantitative T cell assay (T-SPOT.TB) and QuantiFERON-TB-Gold-Test (QFT-G), in differentiating NTM infections ( = 1,407) from culture-confirmed PTB ( = 1,828) and other respiratory diseases ( = 2,652). Read More

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February 2021

A Mycobacterial Systems Resource for the Research Community.

mBio 2021 03 2;12(2). Epub 2021 Mar 2.

Wadsworth Center, New York State Department of Health, Albany, New York, USA

Functional characterization of bacterial proteins lags far behind the identification of new protein families. This is especially true for bacterial species that are more difficult to grow and genetically manipulate than model systems such as and To facilitate functional characterization of mycobacterial proteins, we have established a Mycobacterial Systems Resource (MSR) using the model organism This resource focuses specifically on 1,153 highly conserved core genes that are common to many mycobacterial species, including , in order to provide the most relevant information and resources for the mycobacterial research community. The MSR includes both biological and bioinformatic resources. Read More

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Drug susceptibility distributions of and other non-tuberculous mycobacteria.

Antimicrob Agents Chemother 2021 Feb 22. Epub 2021 Feb 22.

Institute of Medical Microbiology, University of Zurich, Gloriastrasse 28/30, 8006 Zurich, Switzerland.

Recent outbreaks of cardiac surgery-associated infections have highlighted the importance of species differentiation within the complex and pointed to a lack of antibiotic susceptibility data for Using the MGIT 960/EpiCenter TB eXiST platform, we have determined antibiotic susceptibility patterns of 48 clinical isolates and 139 other non-tuberculous mycobacteria including 119 members of the complex and 20 towards clofazimine and other drugs used to treat infections with slowly growing nontuberculous mycobacteria (NTM). MIC, MIC and tentative epidemiological cutoff (ECOFF) values for clofazimine were 0.5 mg/L, 1 mg/L and 2 mg/L for Comparable values were observed for other complex members, lower MIC (≤0. Read More

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February 2021

Prevalence and speciation of non-tuberculous mycobacteria among pulmonary and extrapulmonary tuberculosis suspects in South India.

J Infect Public Health 2021 Mar 19;14(3):320-323. Epub 2021 Feb 19.

Department of Microbiology, Jawaharlal Institute of Postgraduate Medical Education and Research (JIPMER), Pondicherry, India. Electronic address:

Background And Objectives: Non tuberculous mycobacteria (NTM) is an emerging opportunistic pathogen increasing globally and indistinguishable from tuberculosis (TB), which remains a challenge particularly in developing countries. This study aimed to identify the prevalence and diversity of NTM among both pulmonary TB (PTB) and extrpulmonary TB (EPTB) clinical isolates from south India.

Methodology: A total of 7633 specimens from TB suspects (PTB, n = 4327 and EPTB, n = 3306) were collected during the study period (July 2018-March 2020) in a tertiary care hospital. Read More

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A multidisciplinary approach to the management of nontuberculous mycobacterial lung disease: a clinical perspective.

Authors:
Juzar Ali

Expert Rev Respir Med 2021 May 23;15(5):663-673. Epub 2021 Feb 23.

Section of Pulmonary/Critical Care Medicine & Allergy/Immunology, NTM-Bronchiectasis Program & Registry, University Medical Center, New Orleans, Louisiana State University Health Sciences Center, New Orleans, LA, USA.

Introduction: Management of nontuberculous mycobacterial lung disease (NTM-LD) can be encumbered by difficult diagnostic criteria and complex treatment decisions. As prevalence of this debilitating, often refractory, progressive lung disease increases globally, management must evolve beyond antimicrobials to encompass holistic and customized treatments coordinated by practitioners across various specialties.

Areas Covered: This review aims to complement the recently updated NTM-LD treatment guidelines and expand current approaches to diagnosis, treatment, and disease management in a multidisciplinary dimension. Read More

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Pathogenic Determinants of the Complex: An Unsuspected Role for Distributive Conjugal Transfer.

Microorganisms 2021 Feb 10;9(2). Epub 2021 Feb 10.

Department of Laboratory Medicine, Institute of Microbiology, Lausanne University Hospital and University of Lausanne, 1011 Lausanne, Switzerland.

The species comprises six subtypes that were recently classified into six closely related species; (formerly subtype 1), (subtype 2), (subtype 3), (subtype 4), (subtype 5) and (subtype 6). Together with , they form the complex. is the most frequent and most pathogenic species of the complex. Read More

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February 2021

Isolation and identification of nontuberculous mycobacteria from specimens of lower respiratory tract of transplanted patients based on the evaluation of 16SrRNA gene.

Ann Ig 2021 Mar-Apr;33(2):189-197

Immunology Research Center, Tabriz University of Medical Sciences, Tabriz, Iran

Background: Nontuberculous mycobacteria are pervasive microorganisms and are often present as saprophytes in humans, animals, and the environment. Today, these bacteria are known as the most important environmental opportunists and, in the last decades, infections by nontuberculous mycobacteria have multiplied, due to increased immunodeficiency (cancer, transplant recipients, HIV).

Study Design: This study aimed to investigate the infections by nontuberculous mycobacteria in transplanted patients. Read More

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February 2021

Nouveau short-course therapy and morphism mapping for clinical pulmonary .

Antimicrob Agents Chemother 2021 Feb 8. Epub 2021 Feb 8.

Center for Infectious Diseases Research and Experimental Therapeutics, Baylor Research Institute, Baylor University Medical Center, Dallas, Texas.

Standard therapy [isoniazid, rifampin, ethambutol], with or without a macrolide, for pulmonary lasts more than a year. Therefore, shorter treatment duration regimens are required. We used data from 32 Taiwanese patients treated with standard therapy who were followed using repetitive sampling-based sputum time-to-positivity in liquid cultures to calculate kill slopes [γ] based on ordinary differential equations and time-to-extinction of each patient's bacterial burden. Read More

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February 2021

The Benzimidazole SPR719 Shows Promising Concentration-Dependent Activity and Synergy against Nontuberculous Mycobacteria.

Antimicrob Agents Chemother 2021 03 18;65(4). Epub 2021 Mar 18.

Radboudumc Center for Infectious Diseases, Department of Medical Microbiology, Radboud University Medical Center, Nijmegen, the Netherlands

Nontuberculous mycobacterial pulmonary disease (NTM-PD) is emerging worldwide. Currently recommended multidrug treatment regimens yield poor outcomes, and new drugs and regimens are direly needed. SPR719, the active moiety of SPR720, is a new benzimidazole antibiotic with limited data on antimycobacterial activity. Read More

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Human pathogenic (former subtype I) with zoonotic potential isolated from a diseased indoor pet cat, Japan.

Emerg Microbes Infect 2021 Dec;10(1):220-222

Department of Mycobacteriology, Leprosy Research Center, National Institute of Infectious Diseases, Tokyo, Japan.

Nontuberculous mycobacterial (NTM) infections in humans have increased in prevalence in recent decades. is one of the most prevalent human pathogenic NTM species worldwide Herein, we report the first isolation of from an indoor domestic cat in Japan. Comparative genome sequence analysis of the feline isolate showed this pathogen is genetically identical to human pathogenic . Read More

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December 2021

Mendelian Susceptibility to Mycobacterial Disease: The First Case of a Diagnosed Adult Patient in the Czech Republic.

Case Reports Immunol 2020 19;2020:8836685. Epub 2020 Dec 19.

Centre for Cardiovascular Surgery and Transplantation, Brno, Czech Republic.

We present a case of a 42-year-old woman with Mendelian susceptibility to mycobacterial disease. The disease was diagnosed at an adult age with relatively typical clinical manifestations; the skeleton, joints, and soft tissues were affected by nontuberculous mycobacteria: , , and . A previously published loss-of-function and functionally validated variant NM_000416. Read More

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December 2020

Mycobacterium kansasi.

Rev Chilena Infectol 2020 Nov;37(5):563-564

Laboratorio Clínico, Hospital San Juan de Dios, Santiago, Chile.

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November 2020