1,945 results match your criteria Mycobacterium Kansasii


The Use of Amikacin Liposome Inhalation Suspension (Arikayce) in the Treatment of Refractory Nontuberculous Mycobacterial Lung Disease in Adults.

Drug Des Devel Ther 2020 10;14:2287-2294. Epub 2020 Jun 10.

Division of Pulmonary Disease and Critical Care Medicine, Department of Medicine, Virginia Commonwealth University, Richmond, VA, USA.

Nontuberculous mycobacteria (NTM) can cause and perpetuate chronic inflammation and lung infection. Despite having the diagnostic criteria, as defined by the American Thoracic Society (ATS) and Infectious Diseases Society of America (IDSA), clinicians find it challenging to diagnose and treat NTM-induced lung disease. Inhaled antibiotics are suitable for patients with lung infection caused by and other organisms, but until recently, their utility in NTM-induced infection was not established. Read More

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http://dx.doi.org/10.2147/DDDT.S146111DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7293904PMC

Use of MALDI-TOF MS (Bruker Daltonics) for identification of Mycobacterium species isolated directly from liquid medium.

Enferm Infecc Microbiol Clin 2020 Jun 11. Epub 2020 Jun 11.

Servicio de Microbiología, Hospital Universitario Miguel Servet. IIS Aragón, Zaragoza, Spain; Grupo de estudio de las Infecciones por Micobacterias (GEIM), Sociedad Española de Microbiología y Enfermedades Infecciosas, Spain.

Objectives: The aim of this study was to describe the evaluation of the use of MALDI-TOF MS for the identification of non-tuberculous mycobacteria (NTM) and Mycobacterium tuberculosis directly from liquid MGIT cultures from January 2017 to December 2017.

Material/methods: A total of 155 isolates (mainly respiratory) were analyzed by MALDI-TOF MS (Bruker Daltonics) directly from MGIT liquid medium with a previous extraction procedure.

Results: MALDI-TOF MS generated acceptable scores for 152 isolates (98. Read More

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http://dx.doi.org/10.1016/j.eimc.2020.05.011DOI Listing

Prevalence of nontuberculous mycobacteria in a tertiary hospital in Beijing, China, January 2013 to December 2018.

BMC Microbiol 2020 Jun 12;20(1):158. Epub 2020 Jun 12.

Department of Clinical Laboratory, Peking Union Medical College Hospital, Peking Union Medical College, Chinese Academy of Medical Sciences, Beijing, 100730, China.

Background: To investigate the species distribution of non-tuberculous mycobacteria (NTM) among tuberculosis (TB) specimens collected from January 2013 to December 2018 at Peking Union Medical Hospital (Beijing), China. NTM species identification was carried out by DNA microarray chip.

Results: Mycobacterial species were detected in 1514 specimens from 1508 patients, among which NTM accounted for 37. Read More

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http://dx.doi.org/10.1186/s12866-020-01840-5DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7291475PMC

Treatment of pulmonary disease caused by Mycobacterium kansasii.

J Formos Med Assoc 2020 Jun 4;119 Suppl 1:S51-S57. Epub 2020 Jun 4.

Division of Pulmonary and Critical Care Medicine, Kaohsiung Medical University Hospital, Kaohsiung, Taiwan; Department of Internal Medicine, Kaohsiung Medical University Hospital, Kaohsiung, Taiwan; Graduate Institute of Medicine, College of Medicine, Kaohsiung Medical University, Kaohsiung, Taiwan; Department of Respiratory Therapy, Kaohsiung Medical University Hospital, Kaohsiung, Taiwan. Electronic address:

As a cause of lung disease (LD), Mycobacterium kansasii is regarded as a highly virulent species among nontuberculous mycobacteria (NTM). Both the frequency of M. kansasii isolates and global prevalence of M. Read More

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http://dx.doi.org/10.1016/j.jfma.2020.05.018DOI Listing

[Pathological characteristics and molecular diagnosis of non-tuberculosis lung disease].

Zhonghua Bing Li Xue Za Zhi 2020 Jun;49(6):562-567

Department of Pathology, Beijing Chest Hospital, Capital Medical University; Beijing Tuberculosis and Thoracic Tumor Research Institute, Beijing 101149, China.

To investigate the clinicopathological features of non-tuberculosis mycobacterial lung disease and the role of molecular pathology in diagnosis. Forty-five formalin-fixed, paraffin embedded (FFPE) specimens were collected from the Department of Pathology, Beijing Chest Hospital from February 2016 to August 2019. The clinical, imaging and histopathologic features, bacteriologic data and morphologic characteristics of acid fast bacilli (AFB) were analyzed retrospectively. Read More

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http://dx.doi.org/10.3760/cma.j.cn112151-20191028-00669DOI Listing

Evaluation of extracellular vesicles role in BALB/c mice immune modulatory.

Int J Mycobacteriol 2020 Jan-Mar;9(1):58-61

Department of Mycobacteriology and Pulmonary Research, Microbiology Research Center, Pasteur Institute of Iran, Tehran, Iran.

Background: Mycobacterium kansasii as a nontuberculosis mycobacteria, naturally release extracellular vesicles (EVs) with widespread utilities. The aim of the present study was the extraction and biological evaluation of M. kansasii EV and its role in BALB/c mice immune modulatory by considering EVs medical usage specificities. Read More

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http://dx.doi.org/10.4103/ijmy.ijmy_212_19DOI Listing

-Alkyl-2-[4-(trifluoromethyl)benzoyl]hydrazine-1-carboxamides and Their Analogues: Synthesis and Multitarget Biological Activity.

Molecules 2020 May 12;25(10). Epub 2020 May 12.

Department of Organic and Bioorganic Chemistry, Faculty of Pharmacy in Hradec Králové, Charles University, Akademika Heyrovského 1203, 500 05 Hradec Králové, Czech Republic.

Based on the isosterism concept, we have designed and synthesized homologous -alkyl-2-[4-(trifluoromethyl)benzoyl]hydrazine-1-carboxamides (from C to C) as potential antimicrobial agents and enzyme inhibitors. They were obtained from 4-(trifluoromethyl)benzohydrazide by three synthetic approaches and characterized by spectral methods. The derivatives were screened for their inhibition of acetylcholinesterase (AChE) and butyrylcholinesterase (BuChE) via Ellman's method. Read More

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http://dx.doi.org/10.3390/molecules25102268DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7287908PMC

Nontuberculous mycobacteria in patients with suspected tuberculosis and the genetic diversity of Mycobacterium avium in the extreme south of Brazil.

J Bras Pneumol 2020 11;46(2):e20190184. Epub 2020 May 11.

Núcleo de Pesquisa em Microbiologia Médica, Faculdade de Medicina, Universidade Federal do Rio Grande, Rio Grande, RS, Brazil.

Objective: Nontuberculous mycobacteria (NTM) are a heterogeneous group of bacteria that are widely distributed in nature and associated with opportunistic infections in humans. The aims of this study were to identify NTM in patients with suspected tuberculosis who presented positive cultures and to evaluate the genetic diversity of strains identified as Mycobacterium avium.

Methods: We studied pulmonary and extrapulmonary samples obtained from 1,248 patients. Read More

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http://dx.doi.org/10.36416/1806-3756/e20190184DOI Listing

Structural and Functional Characterization of Phosphatidylinositol-Phosphate Biosynthesis in Mycobacteria.

J Mol Biol 2020 May 8. Epub 2020 May 8.

Department of Physiology and Cellular Biophysics, Columbia University, New York, NY 10032, USA. Electronic address:

In mycobacteria, phosphatidylinositol (PI) acts as a common lipid anchor for key components of the cell wall, including the glycolipids phosphatidylinositol mannoside, lipomannan, and lipoarabinomannan. Glycolipids in Mycobacterium tuberculosis, the causative agent of tuberculosis, are important virulence factors that modulate the host immune response. The identity-defining step in PI biosynthesis in prokaryotes, unique to mycobacteria and few other bacterial species, is the reaction between cytidine diphosphate-diacylglycerol and inositol-phosphate to yield phosphatidylinositol-phosphate, the immediate precursor to PI. Read More

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http://dx.doi.org/10.1016/j.jmb.2020.04.028DOI Listing
May 2020
4.333 Impact Factor

Chronic Tenosynovitis of the Upper Extremities Caused by : A Clinical Case and Systematic Review of Literature.

Indian J Plast Surg 2020 Mar 6;53(1):25-35. Epub 2020 Apr 6.

Division of Plastic Surgery, Mayo Clinic, Jacksonville, Florida, United States.

 Chronic tenosynovitis of the upper extremities caused by ( ) is uncommon, but symptoms may overlap with other more common diseases. Late diagnosis and treatment can lead to disfiguration of structures and rupture of tendons, resulting in worse cosmetic outcomes after reconstruction.  We present a clinical case and literature review of in patients with chronic tenosynovitis of upper extremities. Read More

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http://dx.doi.org/10.1055/s-0040-1709377DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7192657PMC

Assessment of current diagnostic algorithm for detection of mixed infection with Mycobacterium tuberculosis and nontuberculous mycobacteria.

J Infect Public Health 2020 Apr 22. Epub 2020 Apr 22.

National Clinical Laboratory on Tuberculosis, Beijing Key Laboratory on Drug-resistant Tuberculosis Research, Beijing Chest Hospital, Capital Medical University, Beijing Tuberculosis and Thoracic Tumor Institute, Beijing, China. Electronic address:

Background: The increasing pulmonary diseases are reported to be affected by mixed infection of Mycobacterium tuberculosis (MTB) and nontuberculous mycobacteria (NTM). In this study, our objective was to assess the efficiency of mycobacterial culture plus DNA sequencing to detect the mixed infections with MTB and various NTM organisms. We also aimed to investigate how efficiently GeneXpert detected MTB in mixed infections with NTM in in vitro models. Read More

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http://dx.doi.org/10.1016/j.jiph.2020.03.017DOI Listing

A zebrafish model of Mycobacterium kansasii infection reveals large extracellular cord formation.

J Infect Dis 2020 Apr 17. Epub 2020 Apr 17.

Institut de Recherche en Infectiologie de Montpellier, Centre National de la Recherche Scientifique UMR, Université de Montpellier, Montpellier, France.

Mycobacterium kansasii is a slow-growing non-tuberculous mycobacteria responsible for co-infections particularly in patients with human immunodeficiency virus. To date, our knowledge of M. kansasii infection has been hampered due to the lack of an effective animal model to study pathogenesis. Read More

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http://dx.doi.org/10.1093/infdis/jiaa187DOI Listing

Comparative Genomic and Transcriptomic Analyses of Subtypes Provide New Insights Into Their Pathogenicity and Taxonomy.

Front Cell Infect Microbiol 2020 24;10:122. Epub 2020 Mar 24.

Pathogen Genomics Laboratory, BESE Division, King Abdullah University of Science and Technology (KAUST), Thuwal, Saudi Arabia.

is an important opportunistic pathogen of humans and has a close phylogenetic relationship with . Seven subtypes (I-VII) have been identified using molecular biology approaches, of which subtype I is the most frequent causative agent of human disease. To investigate the genotypes and pathogenic components of , we sequenced and compared the complete base-perfect genomes of different subtypes. Read More

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http://dx.doi.org/10.3389/fcimb.2020.00122DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7105574PMC
March 2020
2.620 Impact Factor

5-Alkylamino--phenylpyrazine-2-carboxamides: Design, Preparation, and Antimycobacterial Evaluation.

Molecules 2020 Mar 28;25(7). Epub 2020 Mar 28.

Faculty of Pharmacy in Hradec Králové, Charles University, Heyrovského 1203, 500 05 Hradec Králové, Czech Republic.

According to the World Health Organization, tuberculosis is still in the top ten causes of death from a single infectious agent, killing more than 1.7 million people worldwide each year. The rising resistance developed by against currently used antituberculars is an imperative to develop new compounds with potential antimycobacterial activity. Read More

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http://dx.doi.org/10.3390/molecules25071561DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7180572PMC
March 2020
2.416 Impact Factor

Comparison of in vitro Susceptibility of Mycobacteria Against PA-824 to Identify Key Residues of Ddn, the Deazoflavin-Dependent Nitroreductase from .

Infect Drug Resist 2020 11;13:815-822. Epub 2020 Mar 11.

National Clinical Laboratory on Tuberculosis, Beijing Key Laboratory on Drug-Resistant Tuberculosis Research, Beijing Chest Hospital, Capital Medical University, Beijing Tuberculosis and Thoracic Tumor Institute, Beijing, People's Republic of China.

Objective: PA-824 (Pretomanid), a bicyclic nitroimidazole drug, exhibits significant bactericidal activity toward (MTB) in vitro and in vivo, but not against . Through catalytic bioreduction, deazaflavin-dependent nitroreductase (Ddn) within MTB directly converts PA-824 to potent bactericidal products. This study aimed to identify key MTB Ddn residues involved in PA-824 conversion toward development of in vitro surrogate markers for detection of mycobacterial resistance to PA-824. Read More

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http://dx.doi.org/10.2147/IDR.S240716DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7073430PMC

Variability in the Management of Adults with Pulmonary Nontuberculous Mycobacterial Disease.

Clin Infect Dis 2020 Mar 21. Epub 2020 Mar 21.

Saint Louis University, Department of Internal Medicine.

Background: The increasing global prevalence of pulmonary nontuberculous mycobacteria (NTM) disease has called attention to challenges in NTM diagnosis and management. This study is conducted to understand management and outcomes of patients with pulmonary NTM disease at diverse centers across the US.

Methods: We conducted a 10-year (2005-2015) retrospective study at seven Vaccine and Treatment Evaluation Units to evaluate pulmonary NTM treatment outcomes in human immunodeficiency virus-negative adults. Read More

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http://dx.doi.org/10.1093/cid/ciaa252DOI Listing

Protocol of a Nationwide Observational Study among Patients with Nontuberculous Mycobacterium Pulmonary Disease in South Korea (NTM-KOREA).

Tuberc Respir Dis (Seoul) 2020 Apr 10;83(2):141-146. Epub 2020 Mar 10.

Division of Pulmonary and Critical Care Medicine, Department of Internal Medicine, Seoul National University College of Medicine, Seoul, Korea.

Background: The burden of nontuberculous mycobacterial (NTM) pulmonary disease (PD) is increasing globally. To understand the treatment outcomes and prognosis of NTM-PD, a unified registry is needed. In this project, we aim to construct a multicenter prospective observational cohort with NTM-PD in South Korea (NTM-KOREA). Read More

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http://dx.doi.org/10.4046/trd.2019.0077DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7105436PMC

Macrophage Signaling Pathways in Pulmonary Nontuberculous Mycobacteria Infections.

Am J Respir Cell Mol Biol 2020 Mar 11. Epub 2020 Mar 11.

Emory University School of Medicine, 12239, Division of Pulmonary, Allergy, Critical Care, and Sleep Medicine, Atlanta, Georgia, United States.

The incidence and prevalence of nontuberculous mycobacterial lung disease (NTM-LD) is rising worldwide and accounts for most clinical cases of NTM. NTM infections occur in both immunocompetent and immunocompromised hosts. Macrophages are the primary host cells that initiate an immune response to NTM. Read More

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http://dx.doi.org/10.1165/rcmb.2019-0241TRDOI Listing

Incidence, Clinical Manifestation, Treatment Outcome, and Drug Susceptibility Pattern of Nontuberculous Mycobacteria in HIV Patients in Tehran, Iran.

Ethiop J Health Sci 2020 Jan;30(1):75-84

Department of Microbiology, School of Medicine, Tehran University of Medical Sciences, Tehran, Iran.

Background: Nontuberculous mycobacterial (NTM) infections have radically increased worldwide due to the increase in HIV infections. The disease activity increases with progressive immunodeficiency.

Methods: A total of 216 HIV seropositive patients suspected of having mycobacterial infection were recruited for this study. Read More

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http://dx.doi.org/10.4314/ejhs.v30i1.10DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7036467PMC
January 2020

Transposon mutagenesis in Mycobacterium kansasii links a small RNA gene to colony morphology and biofilm formation and identifies 9,885 intragenic insertions that do not compromise colony outgrowth.

Microbiologyopen 2020 04 21;9(4):e988. Epub 2020 Feb 21.

Department of Biology, Brooklyn College, City University of New York, Brooklyn, NY, USA.

Mycobacterium kansasii (Mk) is a resilient opportunistic human pathogen that causes tuberculosis-like chronic pulmonary disease and mortality stemming from comorbidities and treatment failure. The standard treatment of Mk infections requires costly, long-term, multidrug courses with adverse side effects. The emergence of drug-resistant isolates further complicates the already challenging drug therapy regimens and threatens to compromise the future control of Mk infections. Read More

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http://dx.doi.org/10.1002/mbo3.988DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7142372PMC

Septic Arthritis Caused by Mycobacterium Kansasii in a Bone Marrow Transplant Recipient.

J Pediatr Hematol Oncol 2020 Feb 11. Epub 2020 Feb 11.

Departments of Pediatrics.

We report an 18-year-old female individual with septic arthritis due to Mycobacterium kansasii. Three years and 6 months before arthritis, the patient underwent bone marrow transplantation and developed severe chronic graft-versus-host disease. The arthritis was refractory to medication, and she underwent joint lavage of the right foot, hip joint, and elbow joint. Read More

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http://dx.doi.org/10.1097/MPH.0000000000001746DOI Listing
February 2020

Genomic Insights Into the Complex: An Update.

Front Microbiol 2019 15;10:2918. Epub 2020 Jan 15.

Biobank Lab, Department of Molecular Biophysics, Faculty of Biology and Environmental Protection, University of Łódź, Łódź, Poland.

Only very recently, has it been proposed that the hitherto existing subtypes (I-VI) should be elevated, each, to a species rank. Consequently, the former subtypes have been denominated as (former type I), (II), (III), (V), and (VI). The present work extends the recently published findings by using a three-pronged computational strategy, based on the alignment fraction-average nucleotide identity, genome-to-genome distance, and core-genome phylogeny, yet essentially independent and much larger sample, and thus delivers a more refined and complete picture of the complex. Read More

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http://dx.doi.org/10.3389/fmicb.2019.02918DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6974680PMC
January 2020
3.941 Impact Factor

Epidemiology of Non-Tuberculous Mycobacteria isolated from clinical specimens in Madrid, Spain, from 2013 to 2017.

Eur J Clin Microbiol Infect Dis 2020 Jun 24;39(6):1089-1094. Epub 2020 Jan 24.

Department of Clinical Microbiology, IIS-Fundación Jiménez Díaz, Madrid, Spain.

The epidemiology of non-tuberculous mycobacteria (NTM) in Spain is largely unknown because systematic reporting is not compulsory. The aim of our study was to describe the frequency and diversity of NTM species in our region and their distribution according to the source sample, gender, and age of the patients. We performed a multicenter study of all NTM isolated in 24 public hospitals in Madrid from 2013 to 2017. Read More

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http://dx.doi.org/10.1007/s10096-020-03826-7DOI Listing

A prospective study of non-tuberculous mycobacterial disease among tuberculosis suspects at a tertiary care centre in north India.

Indian J Med Res 2019 11;150(5):458-467

National Tuberculosis Institute, Bengaluru, Karnataka, India.

Background & Objectives: The burden of non-tuberculous mycobacterial (NTM) disease is increasing worldwide. The disease shares clinicoradiological features with tuberculosis (TB), Nocardia and several fungal diseases, and its diagnosis is frequently delayed. The present study was performed to determine the frequency of NTM disease among TB suspects in a tertiary care centre in north India. Read More

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http://dx.doi.org/10.4103/ijmr.IJMR_194_19DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6977370PMC
November 2019
1.661 Impact Factor

Identification of Non-Tuberculosis Mycobacteria by Line Probe Assay and Determination of Drug Resistance Patterns of Isolates in Iranian Patients.

Arch Razi Inst 2019 12 1;74(4):375-384. Epub 2019 Dec 1.

Department of Microbiology, School of medicine, Tehran University of Medical Sciences, Tehran, Iran.

The potentially pathogenic Non-Tuberculosis Mycobacteria (NTM) are emerging nowadays which result in pulmonary and non-pulmonary infections in human. This group of bacteria consists of at least 200 different species. While the pulmonary disease is the most common form of NTM infections, NTM can cause diffused infections as well as extrapulmonary infections in every organ, such as bone marrow, skin, eye, and brain. Read More

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http://dx.doi.org/10.22092/ari.2019.127144.1372DOI Listing
December 2019

Crystal structure of a hemerythrin-like protein from Mycobacterium kansasii and homology model of the orthologous Rv2633c protein of M. tuberculosis.

Biochem J 2020 01;477(2):567-581

Burnett School of Biomedical Sciences, College of Medicine, University of Central Florida, Orlando, FL 32827, U.S.A.

Pathogenic and opportunistic mycobacteria have a distinct class of non-heme di-iron hemerythrin-like proteins (HLPs). The first to be isolated was the Rv2633c protein, which plays a role in infection by Mycobacterium tuberculosis (Mtb), but could not be crystallized. This work presents the first crystal structure of an ortholog of Rv2633c, the mycobacterial HLP from Mycobacterium kansasii (Mka). Read More

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http://dx.doi.org/10.1042/BCJ20190827DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6993866PMC
January 2020

Ethambutol-resistant cervical lymphadenitis in an immunocompetent adult patient: A case report and literature review.

J Clin Tuberc Other Mycobact Dis 2020 Feb 6;18:100137. Epub 2019 Dec 6.

Infectious Diseases Unit, Hospital Universitario Central de Asturias, Oviedo University School of Medicine, Oviedo, Spain.

extrapulmonary infections are infrequent in immunocompetent adults. Rifampin (RIF), clarithromycin (CLR), isoniazid (INH) and ethambutol (EMB) are included in all the standard regimens against . We report a case of a healthy 65-year-old male farmer who presented with isolated right supraclavicular lymphadenopathy. Read More

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http://dx.doi.org/10.1016/j.jctube.2019.100137DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6926166PMC
February 2020

Identification of mycobacteria species by molecular methods.

Int Wound J 2020 Apr 20;17(2):245-250. Epub 2019 Dec 20.

Health Services Vocational School, Trakya University, Edirne, Turkey.

In this study, mycobacteria, which were previously identified as Mycobacterium tuberculosis complex (MTC), and mycobacteria other than tuberculosis (MOTT) with cord factor and the p-nitro-alpha-acetyl-amino-beta-hydroxypropiophenone (NAP) test were reanalysed using the polymerase chain reaction-restriction fragment length polymorphism (PCR-RFLP) analysis method in order to confirm the identification, and at the same time, species accepted as MOTT were identified. Although the results of the NAP test were obtained within 3-5 days, the PCR-RFLP results were obtained in 1 day. Ten species identified as MTC with the NAP test and cord factor were confirmed with the PCR-RFLP method. Read More

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http://dx.doi.org/10.1111/iwj.13238DOI Listing

Disseminated infection in a white-tailed deer and implications for public and livestock health.

J Vet Diagn Invest 2020 Jan 17;32(1):147-151. Epub 2019 Dec 17.

Louisiana State University, Baton Rouge, LA (Ford).

We document a case of , a rare, zoonotic bacterium, in a white-tailed deer (WTD; ) in East Baton Rouge Parish, Louisiana. Grossly, the deer had fibrinous pleuropneumonia with yellow, mineralized nodules scattered throughout the lungs and extending to the pleura. The kidneys were enlarged and had numerous pale foci in the cortex. Read More

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http://dx.doi.org/10.1177/1040638719895475DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7003226PMC
January 2020

[Clinical characteristics and drug susceptibility test of nontuberculous mycobacterial lung disease].

Zhonghua Jie He He Hu Xi Za Zhi 2019 Dec;42(12):901-906

Tuberculosis Diagnosis and Treatment Center, Shanghai Pulmonary Hospital, Tongji University, Shanghai Key Lab of Tuberculosis, Shanghai 200433, China.

To investigate the clinical characteristics and drug susceptibility test (DST) of patients infected with different nontuberculous mycobacteria (NTM). The patients with nontuberculous mycobacterial lung disease (NMLD) in Shanghai Pulmonary Hospital from March 2014 to March 2015 were studied retrospectively by analyzing the clinical characteristics, radiological features and DST results. A total of 201 NMLD patients [male 108, age(58±15) yrs] were enrolled into this study including 48 cases of [male 13, age (52±16) yrs],46 cases of [male 46, age (57±16) yrs], 92 cases of [male 43, age (61±13) yrs], and 15 cases of [male 6, age (67±10) yrs]. Read More

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http://dx.doi.org/10.3760/cma.j.issn.1001-0939.2019.12.005DOI Listing
December 2019

Profile of patients with pulmonary non-tuberculous mycobacterial disease mimicking pulmonary tuberculosis.

Indian J Tuberc 2019 Oct 7;66(4):461-467. Epub 2019 May 7.

Government Hospital of Thoracic Medicine, Tambaram, Chennai, India.

Introduction: With the introduction of newer molecular diagnostic tools, an increasing number of Non-tuberculous Mycobacteria (NTM) affecting the respiratory system and mimicking symptoms of pulmonary tuberculosis (PTB) are being identified. They may be misdiagnosed and treated as PTB, often categorized as treatment failures if they do not respond to treatment. This manuscript aims to characterize patients with pulmonary NTM disease. Read More

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http://dx.doi.org/10.1016/j.ijtb.2019.04.013DOI Listing
October 2019

B Cell-Based Vaccine Transduced With ESAT6-Expressing Vaccinia Virus and Presenting α-Galactosylceramide Is a Novel Vaccine Candidate Against ESAT6-Expressing Mycobacterial Diseases.

Front Immunol 2019 29;10:2542. Epub 2019 Oct 29.

Laboratory of Microbiology and Immunology, College of Pharmacy, Kangwon National University, Chuncheon, South Korea.

Early secretory antigenic target-6 (ESAT6) is a potent immunogenic antigen expressed in as well as in some non-tuberculous mycobacteria (NTM), such as . is one of the most clinically relevant species of NTM that causes mycobacterial lung disease, which is clinically indistinguishable from tuberculosis. In the current study, we designed a novel cell-based vaccine using B cells that were transduced with vaccinia virus expressing ESAT6 (vacESAT6), and presenting α-galactosylceramide (αGC), a ligand of invariant NKT cells. Read More

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http://dx.doi.org/10.3389/fimmu.2019.02542DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6830241PMC
October 2019

Cas12a/Guide RNA-Based Platform for Rapid and Accurate Identification of Major Species.

J Clin Microbiol 2020 Jan 28;58(2). Epub 2020 Jan 28.

National Clinical Research Center for Infectious Diseases, Guangdong Key Laboratory of Emerging Infectious Diseases, Shenzhen Third People's Hospital, Southern University of Science and Technology, Shenzhen, China

infection and nontuberculous mycobacteria (NTM) infections exhibit similar clinical symptoms; however, the therapies for these two types of infections are different. Therefore, the rapid and accurate identification of and NTM species is very important for the control of tuberculosis and NTM infections. In the present study, a Cas12a/guide RNA (gRNA)-based platform was developed to identify and most NTM species. Read More

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http://dx.doi.org/10.1128/JCM.01368-19DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6989083PMC
January 2020

Changing epidemiology of nontuberculous mycobacterial lung disease over the last two decades in a region of the Basque country.

ERJ Open Res 2019 Oct 4;5(4). Epub 2019 Nov 4.

Dept of Respiratory Medicine, Hospital Universitario Cruces, Barakaldo, Spain.

Recent studies suggest an increasing prevalence of nontuberculous mycobacteria (NTM) lung disease. The aim of the present study was to describe incidence rates of NTM lung disease and trends therein in our area over a 20-year period. This was a retrospective study of all cases of NTM lung disease between 1997 and 2016 that met the 2007 American Thoracic Society criteria. Read More

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http://dx.doi.org/10.1183/23120541.00110-2018DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6826251PMC
October 2019

The Chemical composition and anti-mycobacterial activities of Trachyspermum copticum and Pelargonium graveolens essential oils.

Recent Pat Antiinfect Drug Discov 2019 Oct 28. Epub 2019 Oct 28.

Department of Medical Microbiology, School of Medicine, Tehran University of Medical Sciences, Iran.

Background: Microbial resistance to antibiotics and their adverse effects related to these antibiotics are the matter of global public health in 21th century. Emergence of drug resistant strains has interested the scientists to find the new antimicrobial agents among the medicinal plant's essential oil.

Methods: Anti-mycobacterial effects of Trachyspermum copticum and Pelargonium graveolens essential oils were assessed against multi-drug resistant clinical strains of Mycobacterium tuberculosis, Mycobacterium kansasii, Mycobacterium fortuitum and standard strain of Mycobacterium tuberculosis H37Rv by a Broth micro-dilution method. Read More

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http://dx.doi.org/10.2174/1574891X14666191028113321DOI Listing
October 2019

Socio-Economic and Environmental Factors Related to Spatial Differences in Human Non-Tuberculous Mycobacterial Diseases in the Czech Republic.

Int J Environ Res Public Health 2019 10 17;16(20). Epub 2019 Oct 17.

Faculty of Regional Development and International Studies, Mendel University in Brno, Tr. Generala Piky 7, 613 00 Brno, Czech Republic.

Non-tuberculous mycobacteria (NTM) are ubiquitous environmental bacteria that can induce pulmonary and non-pulmonary diseases in susceptible persons. It is reported that the prevalence of NTM diseases is increasing in developed countries, but this differs by regions and countries. NTM species distribution and the rate of diseases caused by NTM vary widely in the historical territories of Moravia and Silesia (Czech Republic). Read More

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http://dx.doi.org/10.3390/ijerph16203969DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6843547PMC
October 2019
1 Read

Health providers induced iatrogenic delusions of infestation.

Clin Cosmet Investig Dermatol 2019 11;12:679-681. Epub 2019 Sep 11.

Department of Dermatology, University of Rochester School of Medicine and Dentistry, Rochester, NY 14642, USA.

Patients that suffer from factitial dermatosis mutilate their skin, often lacking any consciousness of self-injury, attributing the resulting lesions to spontaneous development. The case hereby described shows how the health providers' interventions led a patient from a baseline undiagnosed factitious disorder to frank delusions of infestation with , and a relentless search for antibiotic treatments. We highlight the need for educating health practitioners on the characteristics of psycho-cutaneous disorders. Read More

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http://dx.doi.org/10.2147/CCID.S218894DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6745403PMC
September 2019
2 Reads

Case Report: Disseminated Disease in a Patient with Anti-Interferon-Gamma Antibody.

Am J Trop Med Hyg 2019 11;101(5):1066-1069

Division of General Medicine, National Hospital Organization Kyoto Medical Center, Kyoto, Japan.

Disseminated nontuberculous mycobacterial (NTM) infections usually occur in severely immunosuppressed patients. These infections may also occur in previously immunocompetent patients with acquired anti-interferon-gamma antibodies (anti-IFN-γ Abs). A previously healthy 33-year-old man presented with a 3-week history of cough and fever. Read More

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http://dx.doi.org/10.4269/ajtmh.19-0047DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6838586PMC
November 2019
2 Reads

Nontuberculous mycobacteria isolated from specimens of pulmonary tuberculosis suspects, Northern Tunisia: 2002-2016.

BMC Infect Dis 2019 Sep 18;19(1):819. Epub 2019 Sep 18.

Unit of Typing & Genetics of Mycobacteria, Laboratory of Molecular Microbiology, Vaccinology, and Biotechnology Development, Institut Pasteur de Tunis, Université de Tunis El Manar, 13 Place Pasteur, BP74, 1002, Tunis, Tunisia.

Background: Reports on the worldwide ascending trend of pulmonary nontuberculous mycobacteria (NTM) isolation rates and their effective role in respiratory tract infections are compelling. However, as yet, there are no such data relating to Tunisia.

Methods: Here we carried out a retrospective review of mycobacterial cultures originating from Northern Tunisia, which have been processed in the laboratory of mycobacteria of the Institut Pasteur de Tunis, during the time period 2002-2016. Read More

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https://bmcinfectdis.biomedcentral.com/articles/10.1186/s128
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http://dx.doi.org/10.1186/s12879-019-4441-1DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6751674PMC
September 2019
2 Reads

Surgical resection is sufficient for incidentally discovered solitary pulmonary nodule caused by nontuberculous mycobacteria in asymptomatic patients.

PLoS One 2019 12;14(9):e0222425. Epub 2019 Sep 12.

Department of Internal Medicine, Kaohsiung Medical University Hospital, Kaohsiung, Taiwan.

Incidentally discovered solitary pulmonary nodules (SPN) caused by nontuberculous mycobacteria (NTM) is uncommon, and its optimal treatment strategy remains uncertain. This cohort study determined the clinical characteristics and outcome of asymptomatic patients with NTM-SPN after surgical resection. Resected SPNs with culture-positive for NTM in six hospitals in Taiwan during January, 2010 to January, 2017 were identified. Read More

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http://journals.plos.org/plosone/article?id=10.1371/journal.pone.0222425PLOS
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6742351PMC
March 2020
1 Read
3.234 Impact Factor

Prevalence and risk factors of pulmonary nontuberculous mycobacterial infections in the Zhejiang Province of China.

Epidemiol Infect 2019 09 11;147:e269. Epub 2019 Sep 11.

National Clinical Laboratory on Tuberculosis, Beijing Chest Hospital affiliated to Capital Medical University, Beijing Tuberculosis & Thoracic Tumor Research Institute, Beijing, 101149, P.R.China.

Risk factors and prevalence of pulmonary nontuberculous mycobacterial (NTM) diseases were retrospectively evaluated in 1208 suspected pulmonary TB patients seeking care at the Affiliated Hospital of Hangzhou Normal University between July 2018 and December 2018. Further analysis of 390 culture-positive cases demonstrated that 358 (358/390, 91.8%) were infected with Mycobacterium tuberculosis (MTB), 24 (24/390, 6. Read More

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http://dx.doi.org/10.1017/S0950268819001626DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6807301PMC
September 2019
3 Reads
2.535 Impact Factor

Clinico-bacteriological analysis for video-assisted thoracoscopic biopsy of non-tuberculous mycobacteria.

J Thorac Dis 2019 Jul;11(7):2715-2721

Department of General Thoracic Surgery, Tokyo Metropolitan Cancer and Infectious Diseases Center Komagome Hospital, Honkomagome, Bunkyo-ku, Tokyo, Japan.

Background: The prevalence of non-tuberculous mycobacteria (NTM) has been increasing in recent years, and thus the number of related surgeries. In recent studies, a few recent studies reported that NTM patients require preoperative treatment. In addition, some cases are found to be granuloma suspected to be NTM (gsNTM) after surgery. Read More

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http://dx.doi.org/10.21037/jtd.2019.06.33DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6687992PMC
July 2019
1 Read

Screening of Microbial Volatile Organic Compounds for Detection of Disease in Cattle: Development of Lab-scale Method.

Sci Rep 2019 08 20;9(1):12103. Epub 2019 Aug 20.

USDA-APHIS-WS-National Wildlife Research Center, Fort Collins, CO, 80521, USA.

The primary hurdle for diagnosis of some diseases is the long incubation required to culture and confirm the presence of bacteria. The concept of using microbial VOCs as "signature markers" could provide a faster and noninvasive diagnosis. Finding biomarkers is challenging due to the specificity required in complex matrices. Read More

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http://dx.doi.org/10.1038/s41598-019-47907-wDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6702204PMC
August 2019
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Mycobacterium tuberculosis releases an antacid that remodels phagosomes.

Nat Chem Biol 2019 09 19;15(9):889-899. Epub 2019 Aug 19.

Division of Rheumatology, Immunology and Allergy, Brigham and Women's Hospital, Harvard Medical School, Boston, MA, USA.

Mycobacterium tuberculosis (Mtb) is the world's most deadly pathogen. Unlike less virulent mycobacteria, Mtb produces 1-tuberculosinyladenosine (1-TbAd), an unusual terpene nucleoside of unknown function. In the present study 1-TbAd has been shown to be a naturally evolved phagolysosome disruptor. Read More

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http://dx.doi.org/10.1038/s41589-019-0336-0DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6896213PMC
September 2019
5 Reads

Mycobacterium kansasii arthritis of the elbow in an immunocompetent patient with a suspected soft-tissue tumor.

J Infect Chemother 2020 Feb 16;26(2):261-264. Epub 2019 Aug 16.

Divison of Infection Control and Prevention, Osaka University Hospital, Japan.

Mycobacterium kansasii is one of the major non-tuberculous mycobacteria species that typically cause pulmonary diseases. M. kansasii is known to cause septic arthritis as an extrapulmonary disease in immunosuppressed patients or chronic skin disease. Read More

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http://dx.doi.org/10.1016/j.jiac.2019.07.015DOI Listing
February 2020
2 Reads

Bioactivity of Methoxylated and Methylated 1-Hydroxynaphthalene-2-Carboxanilides: Comparative Molecular Surface Analysis.

Molecules 2019 Aug 18;24(16). Epub 2019 Aug 18.

Division of Biologically Active Complexes and Molecular Magnets, Regional Centre of Advanced Technologies and Materials, Faculty of Science, Palacký University, Šlechtitelů 27, 78371 Olomouc, Czech Republic.

A series of twenty-six methoxylated and methylated -aryl-1-hydroxynaphthalene- 2-carboxanilides was prepared and characterized as potential anti-invasive agents. The molecular structure of -(2,5-dimethylphenyl)-1-hydroxynaphthalene-2-carboxamide as a model compound was determined by single-crystal X-ray diffraction. All the analysed compounds were tested against the reference strain and three clinical isolates of methicillin-resistant as well as against and . Read More

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http://dx.doi.org/10.3390/molecules24162991DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6720605PMC

[Frequently Isolated Slow Growing Nontuberculous Mycobacteria from Pulmonary Samples and Evaluation of Drug Susceptibility Testing Results in a Referral Hospital in Turkey].

Mikrobiyol Bul 2019 Jul;53(3):330-335

Ataturk Chest Diseases and Chest Surgery Training and Research Hospital, Ankara, Turkey.

Most of the nontuberculous mycobacteria (NTM) are opportunistic pathogenic microorganisms and free-living in nature. NTM can cause a wide range of infections. However, pulmonary NTM disease is the most frequent clinical picture. Read More

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http://dx.doi.org/10.5578/mb.68091DOI Listing
July 2019
3 Reads

Phenolic N-monosubstituted carbamates: Antitubercular and toxicity evaluation of multi-targeting compounds.

Eur J Med Chem 2019 Nov 1;181:111578. Epub 2019 Aug 1.

Department of Organic and Bioorganic Chemistry, Faculty of Pharmacy in Hradec Králové, Charles University, Akademika Heyrovského 1203, 500 05, Hradec Králové, Czech Republic.

The research of novel antimycobacterial drugs represents a cutting-edge topic. Thirty phenolic N-monosubstituted carbamates, derivatives of salicylanilides and 4-chlorophenol, were investigated against Mycobacterium tuberculosis HRa, HRv including multidrug- and extensively drug-resistant strains, Mycobacterium avium, Mycobacterium kansasii, Mycobacterium aurum and Mycobacterium smegmatis as representatives of nontuberculous mycobacteria (NTM) and for their cytotoxic and cytostatic properties in HepG2 cells. Since salicylanilides are multi-targeting compounds, we determined also inhibition of mycobacterial isocitrate lyase, an enzyme involved in the maintenance of persistent tuberculous infection. Read More

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http://dx.doi.org/10.1016/j.ejmech.2019.111578DOI Listing
November 2019
2 Reads

Shared Pathogenomic Patterns Characterize a New Phylotype, Revealing Transition toward Host-Adaptation Long before Speciation of Mycobacterium tuberculosis.

Genome Biol Evol 2019 08;11(8):2420-2438

Unit for Integrated Mycobacterial Pathogenomics, Institut Pasteur, CNRS UMR 3525, Paris, France.

Tuberculosis remains one of the deadliest infectious diseases of humanity. To better understand the evolutionary history of host-adaptation of tubercle bacilli (MTB), we sought for mycobacterial species that were more closely related to MTB than the previously used comparator species Mycobacterium marinum and Mycobacterium kansasii. Our phylogenomic approach revealed some recently sequenced opportunistic mycobacterial pathogens, Mycobacterium decipiens, Mycobacterium lacus, Mycobacterium riyadhense, and Mycobacterium shinjukuense, to constitute a common clade with MTB, hereafter called MTB-associated phylotype (MTBAP), from which MTB have emerged. Read More

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http://dx.doi.org/10.1093/gbe/evz162DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6736058PMC
August 2019
3 Reads