1,872 results match your criteria Mycobacterium Kansasii


Phylogenomics reveal that Mycobacterium kansasii subtypes are species-level lineages. Description of Mycobacterium pseudokansasii sp. nov., Mycobacterium innocens sp. nov. and Mycobacterium attenuatum sp. nov.

Int J Syst Evol Microbiol 2019 Apr 4. Epub 2019 Apr 4.

1​Institute of Microbiology, Department of Laboratory Medicine, Lausanne University Hospital and University of Lausanne, Lausanne, Switzerland.

Among the species Mycobacterium kansasii, seven subtypes have been previously reported based on the PCR and the restriction fragment length polymorphism of the gene hsp65. Here, we used whole-genome sequencing to refine M. kansasii taxonomy and correct multiple inconsistencies. Read More

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https://www.microbiologyresearch.org/content/journal/ijsem/1
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http://dx.doi.org/10.1099/ijsem.0.003378DOI Listing
April 2019
4 Reads

Derivatives of 3-Aminopyrazine-2-carboxamides: Synthesis, Antimicrobial Evaluation, and in Vitro Cytotoxicity.

Molecules 2019 Mar 28;24(7). Epub 2019 Mar 28.

Faculty of Pharmacy in Hradec Králové, Charles University, Heyrovského 1203, 500 05 Hradec Králové, Czech Republic.

We report the design, synthesis, and in vitro antimicrobial activity of a series of -substituted 3-aminopyrazine-2-carboxamides with free amino groups in position 3 on the pyrazine ring. Based on various substituents on the carboxamidic moiety, the series is subdivided into benzyl, alkyl, and phenyl derivatives. The three-dimensional structures of the title compounds were predicted using energy minimization and low mode molecular dynamics under AMBER10:EHT forcefield. Read More

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http://dx.doi.org/10.3390/molecules24071212DOI Listing
March 2019
1 Read
2.416 Impact Factor

Clinical characteristics, drug resistance, and pathogenic spectrum of patients co-infected with nontuberculous mycobacteria and human-immunodeficiency virus in Chengdu, Sichuan, China.

Chin Med J (Engl) 2019 Mar 27. Epub 2019 Mar 27.

Department of Clinical Laboratory, Public Health Clinical Center of Chengdu, Chengdu, Sichuan 610066, China.

Background: Human-immunodeficiency virus (HIV) infection is increasing worldwide and nontuberculous mycobacteria (NTM) is an established microbiologic cause of pulmonary disease, lymphadenitis, and disseminated disease in cases of advanced immune suppression. Data on patients co-infected with HIV and NTM are limited, this study aimed to analyze the clinical characteristics, drug resistance, and pathogen spectrum of patients co-infected with HIV and NTM in the Chengdu area of China to provide a scientific basis for the prevention, control, diagnosis, and treatment of the disease.

Methods: Data of 59 patients co-infected with HIV and NTM collected from the Public Health Clinical Center of Chengdu, between January 2014 and December 2018, were analyzed. Read More

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http://dx.doi.org/10.1097/CM9.0000000000000235DOI Listing
March 2019
5 Reads
1.016 Impact Factor

Chronic laryngitis caused by Mycobacterium Kansasii in a traveler.

Laryngoscope 2019 Mar 26. Epub 2019 Mar 26.

Head and Neck Institute, Cleveland Clinic Foundation, Cleveland, Ohio.

Chronic laryngitis commonly presents with dysphonia, and infectious causes include tuberculosis and endemic mycoses. We present a 58-year-old female with laryngitis for 5 years, fevers, chills, fatigue, malaise, myalgias, anterior neck pain, and night sweats after multicontinent exposure. Bronchoscopy cultures were negative. Read More

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http://dx.doi.org/10.1002/lary.27952DOI Listing
March 2019
3 Reads

Treatment with a macrolide-containing regimen for Mycobacterium kansasii pulmonary disease.

Respir Med 2019 Mar 30;148:37-42. Epub 2019 Jan 30.

Division of Pulmonary and Critical Care Medicine, Department of Medicine, Samsung Medical Center, Sungkyunkwan University School of Medicine, Seoul, South Korea. Electronic address:

Background: Mycobacterium kansasii is a major pathogen associated with nontuberculous mycobacterial pulmonary disease. For treatment of M. kansasii pulmonary disease, daily therapy with isoniazid, rifampin, and ethambutol is traditionally recommended. Read More

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http://dx.doi.org/10.1016/j.rmed.2019.01.012DOI Listing

Diversity of Nontuberculous Mycobacteria in Kuwait: Rapid Identification and Differentiation of Mycobacterium Species by Multiplex PCR, INNO-LiPA Mycobacteria v2 Assay and PCR Sequencing of rDNA.

Med Princ Pract 2019 Feb 14. Epub 2019 Feb 14.

Department of Microbiology, Faculty of Medicine, Kuwait University, Safat, Kuwait.

Objective: Nontuberculous mycobacteria (NTM) often cause disease that is clinically indistinguishable from tuberculosis. Specific identification is important as treatment varies according to Mycobacterium species causing the infection. This study used multiplex PCR (mPCR) assay for rapid differentiation of mycobacterial growth indicator tube 960 system (MGIT) cultures as Mycobacterium tuberculosis (MTB) or NTM together with INNO LiPA Mycobacteria v2 assay (LiPA) and/or PCR sequencing of rDNA for species-specific identification of selected MTB and all NTM isolates in Kuwait. Read More

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http://dx.doi.org/10.1159/000498910DOI Listing
February 2019
2 Reads

In-vitro evaluation of the antibacterial activity of the essential oils of Micromeria barbata, Eucalyptus globulus and Juniperus excelsa against strains of Mycobacterium tuberculosis (including MDR), Mycobacterium kansasii and Mycobacterium gordonae.

J Infect Public Health 2019 Feb 6. Epub 2019 Feb 6.

CNRS, INRA, UMR 8207-UMET-PIHM, Université de Lille, 369 rue Jules Guesde, CS 20039, 59651, Villeneuve d'Ascq, France.

Background: Mycobacterium spp. are responsible for several diseases, particularly in immunocompromised populations. The spreading of the resistance to antimycobacterial drugs is a significant problem to the public health and requires to find out a new and innovative alternative for the treatment of drug resistant mycobacterial strains. Read More

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http://dx.doi.org/10.1016/j.jiph.2019.01.058DOI Listing
February 2019
2 Reads

Risk factors for developing Mycobacterium kansasii lung disease: A case-control study in Korea.

Medicine (Baltimore) 2019 Feb;98(5):e14281

Department of Internal Medicine.

Previous studies have suggested that development of Mycobacterium kansasii lung disease (MKLD) was associated with COPD, pneumoconiosis, aging, male, immunosuppression, alcohol, malignancy, and certain occupations such as mining and sandblasting. However, previous studies were outdated and used non-comparative statistical methods. We aimed to determine the current risk factors for developing MKLD in Korea by using appropriate statistical techniques. Read More

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http://dx.doi.org/10.1097/MD.0000000000014281DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6380715PMC
February 2019
10 Reads

Multicenter evaluation of the biochip assay for rapid detection of mycobacterial isolates in smear-positive specimens.

Int J Infect Dis 2019 Apr 24;81:46-51. Epub 2019 Jan 24.

State Key Laboratory for Diagnosis and Treatment of Infectious Diseases, Collaborative Innovation Center for Diagnosis and Treatment of Infectious Diseases, The First Affiliated Hospital, College of Medicine, Zhejiang University, No. 79 Qingchun Road, Shangcheng District, Hangzhou 310003, Zhejiang, China. Electronic address:

Objectives: The objective of this study was to conduct a multicentre evaluation of the performance of the biochip assay in the rapid identification of mycobacteria in smear-positive sputum specimens.

Methods: A total of 1751 sputum specimens were obtained from 7 cities in Zhejiang, China. All of the specimens were used for the discrimination of Mycobacterium species using the biochip assay, and the results were compared to the golden standard method of culture, hsp65, 16S rRNA and rpoB sequence analysis. Read More

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http://dx.doi.org/10.1016/j.ijid.2019.01.036DOI Listing
April 2019
7 Reads

Nontuberculous mycobacterial infection after lung transplantation: a report of four cases.

Surg Case Rep 2019 Jan 23;5(1):11. Epub 2019 Jan 23.

Department of General Thoracic Surgery, Osaka University Graduate School of Medicine, 2-2 Yamadaoka, Suita-shi, Osaka, Japan.

Background: Nontuberculous mycobacterium (NTM) infection in a patient in an immunosuppressed state caused by increased use of immunosuppressive or biological agents is a serious clinical problem. Mycobacterium avium complex is the most common involved pathogen, followed by Mycobacterium abscessus (MABSC), while Mycobacterium kansasii is not a major concern. The rate of infection rate in lung transplant recipients is reported to range from 1. Read More

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http://dx.doi.org/10.1186/s40792-019-0565-1DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6346695PMC
January 2019
3 Reads

Distribution and expression of esat-6 and cfp-10 in non-tuberculous mycobacteria isolated from lymph nodes of slaughtered cattle in Switzerland.

J Vet Diagn Invest 2019 Mar 13;31(2):217-221. Epub 2019 Jan 13.

Institute of Veterinary Bacteriology (Scherrer, Landolt, Friedel), Vetsuisse Faculty, University of Zurich, Zurich, Switzerland.

The most commonly used tools for tuberculosis testing in cattle, the tuberculin skin test and the interferon-γ release assay, detect immune reactivity to various antigens of Mycobacterium bovis, including ESAT-6 and CFP-10. However, some non-tuberculous mycobacteria (NTM) can also harbor the cfp-10 and/or esat-6 genes, which can lead to false-positive results. We tested 77 NTM isolates belonging to 22 different species from lymph nodes of healthy slaughtered cattle for the occurrence of cfp-10 and esat-6. Read More

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http://dx.doi.org/10.1177/1040638718824074DOI Listing
March 2019
18 Reads

Prevalence of nontuberculous mycobacteria and high efficacy of d-cycloserine and its synergistic effect with clarithromycin against and .

Infect Drug Resist 2018 7;11:2521-2532. Epub 2018 Dec 7.

Tuberculosis Research Center, Hormozgan University of Medical Sciences, Bandar Abbas, Iran.

Background: The prevalence of pulmonary disease caused by nontuberculous mycobacteria (NTM) is reportedly on the rise in the world. Some of the species are resistant to various antibiotics; hence, limited treatment options are available. The aims of this study were to investigate the prevalence of NTM and to determine the effect of d-cycloserine against and isolated from clinical specimens to find out the synergistic effect of d-cycloserine and clarithromycin. Read More

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http://dx.doi.org/10.2147/IDR.S187554DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6290872PMC
December 2018
3 Reads

Host Variability in NTM Disease: Implications for Research Needs.

Front Microbiol 2018 3;9:2901. Epub 2018 Dec 3.

Laboratory of Chronic Airway Infection, Pulmonary Branch, Division of Intramural Research, National Heart, Lung, and Blood Institute, National Institutes of Health, Bethesda, MD, United States.

Non-tuberculous mycobacteria (NTM) are ubiquitous environmental organisms that may cause opportunistic infections in susceptible hosts. Lung infections in immunocompetent persons with structural lung disease are most common, while disseminated disease occurs primarily in immunocompromised individuals. Human disease caused by certain species, such as complex, , and , is increasing in incidence and varies by geographic distribution. Read More

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http://dx.doi.org/10.3389/fmicb.2018.02901DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6286975PMC
December 2018
1 Read

Predictors of developing Mycobacterium kansasii pulmonary disease within 1 year among patients with single isolation in multiple sputum samples: A retrospective, longitudinal, multicentre study.

Sci Rep 2018 Dec 13;8(1):17826. Epub 2018 Dec 13.

Department of Internal Medicine, National Taiwan University Hospital, Taipei, Taiwan.

The clinical significance of a single Mycobacterium kansasii (MK) isolation in multiple sputum samples remains unknown. We conducted this study to evaluate the outcome and predictors of developing MK-pulmonary disease (PD) within 1 year among these patients. Patients with a single MK isolation from ≥3 sputum samples collected within 3 months and ≥2 follow-up sputum samples and chest radiography in the subsequent 9 months between 2008 and 2016 were included. Read More

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http://dx.doi.org/10.1038/s41598-018-36255-wDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6292854PMC
December 2018

Species Typing of Nontuberculous Mycobacteria by Use of Deoxyribozyme Sensors.

Clin Chem 2019 Feb 6;65(2):333-341. Epub 2018 Dec 6.

Division of Immunity and Pathogenesis, Burnett School of Biomedical Sciences, College of Medicine, University of Central Florida, Orlando, FL;

Background: Nontuberculous mycobacteria (NTM) species are a rising threat, especially to patients living with pulmonary comorbidities. Current point-of-care diagnostics fail to adequately identify and differentiate NTM species from (). Definitive culture- and molecular-based testing can take weeks to months and requires sending samples out to specialized diagnostic laboratories. Read More

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http://dx.doi.org/10.1373/clinchem.2018.295212DOI Listing
February 2019
4 Reads

Cutaneous Mycobacterial Infections.

Clin Microbiol Rev 2018 01 14;32(1). Epub 2018 Nov 14.

Servicio de Dermatología y Departamento de Micología, Hospital General de México, Mexico City, Mexico.

Humans encounter mycobacterial species due to their ubiquity in different environmental niches. In many individuals, pathogenic mycobacterial species may breach our first-line barrier defenses of the innate immune system and modulate the activation of phagocytes to cause disease of the respiratory tract or the skin and soft tissues, sometimes resulting in disseminated infection. Cutaneous mycobacterial infections may cause a wide range of clinical manifestations, which are divided into four main disease categories: (i) cutaneous manifestations of infection, (ii) Buruli ulcer caused by and other related slowly growing mycobacteria, (iii) leprosy caused by and , and (iv) cutaneous infections caused by rapidly growing mycobacteria. Read More

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http://dx.doi.org/10.1128/CMR.00069-18DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6302357PMC
January 2018
6 Reads

Epidemiology of pulmonary disease due to nontuberculous mycobacteria in Southern China, 2013-2016.

BMC Pulm Med 2018 Nov 9;18(1):168. Epub 2018 Nov 9.

National Clinical Laboratory on Tuberculosis, Beijing Key laboratory on Drug-resistant Tuberculosis Research,, Beijing Chest Hospital, Beijing Tuberculosis and Thoracic Tumor Institute, No. 9, Beiguan Street, Tongzhou District, Beijing, 101149, People's Republic of China.

Background: Pulmonary nontuberculous mycobacteria (NTM) disease is of increasing public health concern in China. Information is limited regarding risk factors associated with this disease in China. The objective of this study was to describe the epidemiology of pulmonary disease due to NTM in Southern China. Read More

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https://bmcpulmmed.biomedcentral.com/articles/10.1186/s12890
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http://dx.doi.org/10.1186/s12890-018-0728-zDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6230232PMC
November 2018
20 Reads
2.490 Impact Factor

Therapy for Infection: Beyond 2018.

Front Microbiol 2018 24;9:2271. Epub 2018 Sep 24.

Central New York Research Corporation, Syracuse, NY, United States.

The current standard of care therapy for pulmonary infection is isoniazid (300 mg/day), rifampin (600 mg/day), and ethambutol (15 mg/kg/day) for 12 months after achieving sputum culture negativity. Rifampin is the key drug in this regimen. The contribution of isoniazid is unclear since its MICs against are near the peak achievable serum levels and more than 100-fold greater than the MICs for . Read More

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http://dx.doi.org/10.3389/fmicb.2018.02271DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6166578PMC
September 2018

Recent advances in molecular diagnostics and understanding mechanisms of drug resistance in nontuberculous mycobacterial diseases.

Infect Genet Evol 2018 Oct 11. Epub 2018 Oct 11.

Division of Pulmonary and Critical Care Medicine, Department of Medicine, Samsung Medical Center, Sungkyunkwan University School of Medicine, Seoul, South Korea. Electronic address:

Accumulating evidence suggests that human infections caused by nontuberculous mycobacteria (NTM) are increasing worldwide, indicating that NTM disease is no longer uncommon in many countries. As a result of an increasing emphasis on the importance of differential identification of NTM species, several molecular tools have recently been introduced in clinical and experimental settings. These advances have led to a much better understanding of the diversity of NTM species with regard to clinical aspects and the potential factors responsible for drug resistance that influence the different outcomes of NTM disease. Read More

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https://linkinghub.elsevier.com/retrieve/pii/S15671348183078
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http://dx.doi.org/10.1016/j.meegid.2018.10.003DOI Listing
October 2018
2 Reads

Lymphadenitis by non-tuberculous mycobacteria in children.

Pediatr Int 2018 Dec 10;60(12):1062-1067. Epub 2018 Dec 10.

Department of Paediatrics, Archbishop Makarios III Hospital, Nicosia, Cyprus.

Background: Non-tuberculous mycobacteria (NTM) constitute an important cause of cervical lymphadenitis in immunocompetent children. The aims of this study were to estimate the incidence of lymphadenitis due to NTM in children in Cyprus and to describe the characteristics, diagnostic approach, management and outcome of such infections.

Methods: Children aged 1-5 years old, evaluated at Archbishop Makarios III Hospital, Nicosia, Cyprus, from 1 January 2007 to 31 December 2016 for lymphadenopathy, were included in the study. Read More

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http://dx.doi.org/10.1111/ped.13708DOI Listing
December 2018
7 Reads

Dibasic Derivatives of Phenylcarbamic Acid against Mycobacterial Strains: Old Drugs and New Tricks?

Molecules 2018 Sep 28;23(10). Epub 2018 Sep 28.

Global Change Research Institute CAS, Belidla 986/4a, CZ-603 00 Brno, Czech Republic.

In order to provide a more detailed view on the structure⁻antimycobacterial activity relationship () of phenylcarbamic acid derivatives containing two centers of protonation, 1-[2-[({[2-/3-(alkoxy)phenyl]amino}carbonyl)oxy]-3-(dipropylammonio)propyl]pyrrolidinium oxalates (⁻)/dichlorides (⁻) as well as 1-[2-[({[2-/3-(alkoxy)phenyl]amino}carbonyl)oxy]-3-(di-propylammonio)propyl]azepanium oxalates (⁻)/dichlorides (⁻; alkoxy = butoxy to heptyloxy) were physicochemically characterized by estimation of their surface tension (γ; Traube's stalagmometric method), electronic features (log ; UV/Vis spectrophotometry) and lipophilic properties (log ; isocratic RP-HPLC) as well. The experimental log dataset was studied together with computational logarithms of partition coefficients (log ) generated by various methods based mainly on atomic or combined atomic and fragmental principles. Similarities and differences between the experimental and lipophilicity descriptors were analyzed by unscaled principal component analysis (PCA). Read More

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http://dx.doi.org/10.3390/molecules23102493DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6222509PMC
September 2018
3 Reads

Genetic Diversity and Prevalence of Nontuberculous Mycobacteria Isolated from Clinical Samples in Tehran, Iran.

Microb Drug Resist 2019 Mar 25;25(2):264-270. Epub 2018 Sep 25.

1 Department of Mycobacteriology and Pulmonary Research, Pasteur Institute of Iran , Tehran, Iran .

The prevalence of nontuberculous mycobacteria (NTM) has increased in tuberculosis (TB)-suspected clinical samples. These bacteria are now recognized as important emerging pathogens, which affect both immunocompetent and immunocompromised individuals. The aim of this study was to evaluate the frequency of NTM in clinical samples and to efficacy of genomic loci as targets for detection of NTM species. Read More

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http://dx.doi.org/10.1089/mdr.2018.0150DOI Listing
March 2019
22 Reads
2.524 Impact Factor

Design, Synthesis and Evaluation of -pyrazinylbenzamides as Potential Antimycobacterial Agents.

Molecules 2018 Sep 18;23(9). Epub 2018 Sep 18.

Faculty of Pharmacy in Hradec Králové, Charles University, Heyrovského 1203, Hradec Králové 500 05, Czech Republic.

Three series of -(pyrazin-2-yl)benzamides were designed as retro-amide analogues of previously published -phenylpyrazine-2-carboxamides with in vitro antimycobacterial activity. The synthesized retro-amides were evaluated for in vitro growth inhibiting activity against H37Rv (), three non-tuberculous mycobacterial strains (, , ) and selected bacterial and fungal strains of clinical importance. Regarding activity against , most -pyrazinylbenzamides (retro-amides) possessed lower or no activity compared to the corresponding -phenylpyrazine-2-carboxamides with the same substitution pattern. Read More

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http://dx.doi.org/10.3390/molecules23092390DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6225228PMC
September 2018
5 Reads
2.420 Impact Factor

Drug susceptibility testing of slowly growing non-tuberculous mycobacteria using slomyco test-system.

PLoS One 2018 17;13(9):e0203108. Epub 2018 Sep 17.

Department of problems of laboratory diagnostics of tuberculosis and pathomorphology, Scientific and Clinical Antituberculosis Center of Moscow Government Health Department, Moscow, Russian Federation.

Objective: The objective of the research was to assess the susceptibility of the slowly growing nontuberculous mycobacteria strains to the antimicrobial drugs used for mycobaterioses treatment using SLOMYCO test system.

Materials And Methods: We assessed 363 NTM strains: 177 MAC (161 M. avium, 16 M. Read More

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http://journals.plos.org/plosone/article?id=10.1371/journal.pone.0203108PLOS
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6141080PMC
February 2019
3 Reads

[Interferon gamma release assay tests and nontuberculous mycobacteria].

Rev Mal Respir 2018 Oct 13;35(8):900-901. Epub 2018 Sep 13.

Service de pneumologie et réanimation, CHU Amiens Picardie, université Picardie Jules-Verne, EA 4294, 80054 Amiens cedex 1, France.

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https://linkinghub.elsevier.com/retrieve/pii/S07618425183028
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http://dx.doi.org/10.1016/j.rmr.2018.08.017DOI Listing
October 2018
1 Read

Double lung transplantation in an HIV-positive patient with Mycobacterium kansasii infection.

Transpl Infect Dis 2019 Feb 3;21(1):e12999. Epub 2018 Oct 3.

Département de Microbiologie médicale et Infectiologie, Centre Hospitalier de l'Université de Montréal, Montréal, Québec, Canada.

Good outcomes with kidney and liver transplantation in HIV-positive patients have led clinicians to recommend lung transplantation in HIV-positive patients based on extrapolated data. Pre-transplant mycobacterial infection is associated with an increased risk of developing new infection or aggravating existing infection, though it does not contraindicate transplantation in non-HIV-infected patients. However, no data exists regarding the outcome of HIV-positive patients with pre-transplant mycobacterial infection. Read More

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http://doi.wiley.com/10.1111/tid.12999
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http://dx.doi.org/10.1111/tid.12999DOI Listing
February 2019
5 Reads

Mycobacterium Kansasii Infection and Microscopic Polyangiitis: An Unexpected Association.

Cureus 2018 Jun 18;10(6):e2831. Epub 2018 Jun 18.

Medicine, University of Arizona College of Medicine/mihs, Phoenix, USA.

 () is a nontuberculous mycobacterium, which mainly infects the lungs in immunocompromised patients. We present here the case of a 27-year-old immunocompetent patient who developed pulmonary-renal syndrome, manifested with lung cavitation, miliary nodules, and necrotizing glomerulonephritis accompanied by elevated titers of myeloperoxidase antibody. Cultures from bronchoalveolar lavage were positive for , and the patient was treated with an anti-mycobacterial regimen. Read More

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http://dx.doi.org/10.7759/cureus.2831DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6101464PMC
June 2018
29 Reads

Laryngeal Inflammatory Pseudotumour Secondary to .

Case Rep Pathol 2018 9;2018:9356243. Epub 2018 Jul 9.

Department of Otolaryngology, Torbay Hospital, UK.

Background: Inflammatory pseudotumours (IPT) are rare benign tumours characterised by spindle-shaped histiocyte proliferation often mimicking a soft tissue sarcoma. They can occur in different parts of the body and various aetiological factors have been proposed. To our knowledge this is the first case report of IPT of the larynx caused by mycobacterial disease. Read More

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http://dx.doi.org/10.1155/2018/9356243DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6076934PMC
July 2018
2 Reads

Treatment of Other Nontuberculous Mycobacteria.

Semin Respir Crit Care Med 2018 Jun 2;39(3):377-382. Epub 2018 Aug 2.

Department of Respiratory Diseases, Amiens University Hospital, Amiens, France.

Nontuberculous mycobacteria (NTM) are numerous, and for the vast majority of them, randomized studies are lacking and data regarding optimal treatment are limited. When complex (MAC) and are excluded, the main NTM are , and . Treatment is long (at least 12 months after culture conversion according to recommendations by scientific societies) and difficult (at least three drugs are required, each of which have potential adverse events). Read More

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http://www.thieme-connect.de/DOI/DOI?10.1055/s-0038-1660473
Publisher Site
http://dx.doi.org/10.1055/s-0038-1660473DOI Listing
June 2018
29 Reads

Dynamics of Immune Responses during Experimental Infection of Cynomolgus Monkeys .

Mediators Inflamm 2018 5;2018:8354902. Epub 2018 Jun 5.

Guangdong Provincial Key Laboratory of Laboratory Animals, Guangdong Laboratory Animals Monitoring Institute, Guangzhou 510663, China.

To profile the dynamic changes of immune responses for infection, 3 cynomolgus monkeys were experimentally infected with by intratracheal inhalation of 1 × 10 CFU bacteria per monkey. Every 2 to 4 weeks, tuberculin skin testings (TSTs) were performed and blood samples were collected for immunoassay. Multiple cytokines in a single sample were measured by Luminex xMAP technologies. Read More

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http://dx.doi.org/10.1155/2018/8354902DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6008762PMC
October 2018
5 Reads

In Vitro Anti-mycobacterial Activity of Three Medicinal Plants of Lamiaceae Family.

Recent Pat Antiinfect Drug Discov 2018 ;13(3):240-245

Department of Medical Microbiology, School of Medicine, Tehran University of Medical Sciences, Tehran, Iran.

Background: Mycobacterium tuberculosis as an intracellular pathogen causes Tuberculosis (TB). Due to the long time required for treatment, hepatotoxicity of drugs and also emergence of Multidrug-Resistant (MDR) and Extremely Drug Resistant (XDR) strains, TB is currently a major public health problem. Some medicinal plants possess remarkable activity against Mycobacterium. Read More

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http://dx.doi.org/10.2174/1574891X13666180626170155DOI Listing
April 2019
21 Reads

Whole genome sequence of Mycobacterium kansasii isolates of the genotype 1 from Brazilian patients with pulmonary disease demonstrates considerable heterogeneity.

Mem Inst Oswaldo Cruz 2018 Jun 25;113(9):e180085. Epub 2018 Jun 25.

Fundação Oswaldo Cruz-Fiocruz, Instituto Oswaldo Cruz, Laboratório de Biologia Molecular Aplicada a Micobactérias, Rio de Janeiro, RJ, Brasil.

Mycobacterium kansasii is an opportunistic pathogen and one of the most commonly encountered species in individuals with lung disease. We here report the complete genome sequence of 12 clinical isolates of M. kansasii from patients with pulmonary disease in Brazil. Read More

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http://dx.doi.org/10.1590/0074-02760180085DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6012682PMC
June 2018
15 Reads

Clinical, radiological and molecular features of Mycobacterium kansasii pulmonary disease.

Respir Med 2018 06 9;139:91-100. Epub 2018 May 9.

Department of Applied Microbiology, Institute of Microbiology, Faculty of Biology, University of Warsaw, Warsaw, Poland. Electronic address:

Background: Studies concerning sociodemographic, clinical, and laboratory features of Mycobacterium kansasii pulmonary disease are few and based on small patient cohorts. The objective of the study was to evaluate characteristics of patients from whom M. kansasii respiratory isolates were recovered and to provide a detailed description of M. Read More

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http://dx.doi.org/10.1016/j.rmed.2018.05.007DOI Listing
June 2018
9 Reads
3.090 Impact Factor

Disseminated mycobacteriosis caused by Mycobacterium kansasii in a pot-bellied pig.

J Vet Diagn Invest 2018 Jul 1;30(4):646-650. Epub 2018 Jun 1.

Indiana Animal Disease Diagnostic Laboratory and the Departments of Comparative Pathobiology (Schafbuch, Ramos-Vara), College of Veterinary Medicine, Purdue University, West Lafayette, IN.

A 1.5-y-old spayed female Juliana pot-bellied pig was presented to the Purdue University Veterinary Teaching Hospital with a history of wasting and anorexia. Enlarged and partially mineralized lymph nodes were identified on radiographs and computed tomography scan. Read More

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http://dx.doi.org/10.1177/1040638718780189DOI Listing
July 2018
1 Read

Chronic Tenosynovitis due to in an Immunocompetent Host.

Case Rep Infect Dis 2018 16;2018:3297531. Epub 2018 Apr 16.

Department of Medicine, Lakeland Health, St. Joseph, MI, USA.

We report a case of a healthy 56-year-old male who presented with chronic swelling and erythema in his right hand. He had a prior chemical exposure several years ago and subsequent exposure to freshwater, fish tank, and soil. Laboratory data showed a slightly elevated CRP. Read More

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http://dx.doi.org/10.1155/2018/3297531DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5926486PMC
April 2018
5 Reads

Clofazimine for the Treatment of Mycobacterium kansasii.

Antimicrob Agents Chemother 2018 Aug 27;62(8). Epub 2018 Jul 27.

Center for Infectious Diseases Research and Experimental Therapeutics, Baylor Research Institute, Baylor University Medical Center, Dallas, Texas, USA.

pulmonary infection is a global problem. Standard combination therapy consists of isoniazid at 300 mg/day, rifampin at 600 mg/day, and ethambutol at 15 mg/kg of body weight/day for 18 months. Coincubation of with different clofazimine concentrations over 7 days in test tubes resulted in a maximal kill (maximum effect []) of 2. Read More

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http://aac.asm.org/lookup/doi/10.1128/AAC.00248-18
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http://dx.doi.org/10.1128/AAC.00248-18DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6105821PMC
August 2018
19 Reads

Nontuberculous mycobacterial lung disease in a high tuberculosis incidence setting in Brazil.

J Bras Pneumol 2018 Apr;44(2):106-111

Hospital Sanatório Partenon, Porto Alegre, RS, Brasil.

Objective: The incidence of lung disease caused by nontuberculous mycobacteria (NTM) has been increasing worldwide. In Brazil, there are few studies about nontuberculous mycobacterial lung disease (NTMLD), and its prevalence is yet to be known. Our objective was to determine the specific etiology of the disease in the state of Rio Grande do Sul, Brazil, as well as the frequency and diversity of NTM species in our sample of patients. Read More

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http://dx.doi.org/10.1590/s1806-37562017000000213DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6044650PMC
April 2018
3 Reads

Profiling non-tuberculous mycobacteria in an Asian setting: characteristics and clinical outcomes of hospitalized patients in Singapore.

BMC Pulm Med 2018 May 22;18(1):85. Epub 2018 May 22.

Department of Respiratory and Critical Care Medicine, Tan Tock Seng Hospital, 11 Jalan Tan Tock Seng, Singapore, 308433, Singapore.

Background: Non-tuberculous mycobacteria (NTM) infection is an increasing problem worldwide. The epidemiology of NTM in most Asian countries is unknown. This study investigated the epidemiology, and clinical profile of inpatients in whom NTM was isolated from various anatomical sites in a Singaporean population attending a major tertiary referral centre. Read More

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http://dx.doi.org/10.1186/s12890-018-0637-1DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5964916PMC
May 2018
15 Reads

Pulmonary Infections with Nontuberculous Mycobacteria, Catalonia, Spain, 1994-2014.

Emerg Infect Dis 2018 06;24(6):1091-1094

In Spain, systematic reporting of pulmonary infections with nontuberculous mycobacteria is not mandatory. Therefore, to determine trends, we retrospectively identified cases for January 1994-December 2014 in Catalonia. Over the 21 years, prevalence increased and was associated with being male. Read More

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http://dx.doi.org/10.3201/eid2406.172095DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6004863PMC
June 2018
5 Reads

Prognosis of chronic pulmonary aspergillosis in patients with pulmonary non-tuberculous mycobacterial disease.

Respir Investig 2018 Jul 11;56(4):326-331. Epub 2018 May 11.

Department of Internal Medicine, National Hospital Organization Kinki-chuo Chest Medical Center, Nagasone-cho 1180, Kita-ku, Sakai-city 591-8555, Osaka, Japan. Electronic address:

Background: Pulmonary non-tuberculous mycobacterial disease (PNTM) is a known risk factor for chronic pulmonary aspergillosis (CPA). However, few studies have focused on the prognosis of PNTM-associated CPA. In the present investigation, we aimed to elucidate the clinical course and prognostic factors of CPA in patients with PNTM. Read More

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http://dx.doi.org/10.1016/j.resinv.2018.04.002DOI Listing
July 2018
7 Reads

Activity of Clofazimine against Nontuberculous Mycobacteria Isolated in Beijing, China.

Antimicrob Agents Chemother 2018 Jul 26;62(7). Epub 2018 Jun 26.

National Clinical Laboratory on Tuberculosis, Beijing Key laboratory for Drug-Resistant Tuberculosis Research, Beijing Chest Hospital, Capital Medical University, Beijing Tuberculosis and Thoracic Tumor Institute, Beijing, China

Due to the natural resistance of nontuberculous mycobacteria (NTM) to many antibiotics, the treatment of diseases caused by NTM is often long-term but unsuccessful. The main goal of this study was to evaluate the susceptibilities to clofazimine of 209 isolates consisting of different NTM species isolated in Beijing, China. Furthermore, 47 reference strains were also tested, including 30 rapidly growing mycobacterium (RGM) species and 17 slowly growing mycobacterium (SGM) species. Read More

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http://dx.doi.org/10.1128/AAC.00072-18DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6021646PMC
July 2018
11 Reads

Anti-interferon-γ auto-anti-body and disseminated non-tuberculous mycobacteria infections in thyroid cancer: a case report.

QJM 2018 Sep;111(9):647-648

Department of Pathology, Taoyuan General Hospital, Ministry of Health and Welfare, Taoyuan City, Taiwan.

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http://dx.doi.org/10.1093/qjmed/hcy094DOI Listing
September 2018
3 Reads

New lipophilic isoniazid derivatives and their 1,3,4-oxadiazole analogues: Synthesis, antimycobacterial activity and investigation of their mechanism of action.

Eur J Med Chem 2018 May 10;151:824-835. Epub 2018 Apr 10.

Department of Organic and Bioorganic Chemistry, Faculty of Pharmacy in Hradec Králové, Charles University, Akademika Heyrovského 1203, 500 05, Hradec Králové, Czech Republic. Electronic address:

The development of novel drugs is essential for the treatment of tuberculosis and other mycobacterial infections in future. A series of N-alkyl-2-isonicotinoylhydrazine-1-carboxamides was synthesized from isoniazid (INH) and then cyclized to N-alkyl-5-(pyridin-4-yl)-1,3,4-oxadiazole-2-amines. All derivatives were characterised spectroscopically. Read More

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http://dx.doi.org/10.1016/j.ejmech.2018.04.017DOI Listing
May 2018
15 Reads

MALDI Spectra Database for Rapid Discrimination and Subtyping of .

Front Microbiol 2018 3;9:587. Epub 2018 Apr 3.

Department of Applied Microbiology, Faculty of Biology, Institute of Microbiology, University of Warsaw, Warsaw, Poland.

is an emerging non-tuberculous mycobacterial (NTM) pathogen capable of causing severe lung disease. Of the seven currently recognized genotypes (I-VII), genotypes I and II are most prevalent and have been associated with human disease, whereas the other five (III-VII) genotypes are predominantly of environmental origin and are believed to be non-pathogenic. Subtyping of serves as a valuable tool to guide clinicians in pursuing diagnosis and to initiate the proper timely treatment. Read More

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http://dx.doi.org/10.3389/fmicb.2018.00587DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5893902PMC
April 2018
8 Reads
3.941 Impact Factor

osteomyelitis - a masquerading disease.

JMM Case Rep 2018 Jan 2;5(1):e005114. Epub 2018 Jan 2.

Royal Stoke University Hospital, Newcastle Road, Stoke-on-Trent ST4 6QG, UK.

Introduction: Non-tuberculous mycobacteria (NTM) are environmental bacteria capable of causing an opportunistic myriad of infections. , one such NTM, is responsible for causing pulmonary disease in immunocompromised patients. Rare extrapulmonary manifestations such as lymphadenitis, osteoarticular manifestations, and skin and soft tissue infections are also observed. Read More

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http://dx.doi.org/10.1099/jmmcr.0.005114DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5857369PMC
January 2018
1 Read

B3LYP Study of 3-hydroxynaphthalene-2-carboxanilide para-derivatives.

Acta Chim Slov 2018 Mar;65(1):23-33

A systematic DFT investigation of 3-hydroxy-N-phenylnaphthalene-2-carboxamide and its sixteen para-derivatives is presented. The structural analysis showed that the energetically preferred conformation of all derivatives is practically planar and it is stabilised via intramolecular hydrogen bonds occurring between (C)O.. Read More

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March 2018
3 Reads

Molecular typing of Mycobacterium kansasii using pulsed-field gel electrophoresis and a newly designed variable-number tandem repeat analysis.

Sci Rep 2018 Mar 13;8(1):4462. Epub 2018 Mar 13.

Department of Applied Microbiology, Institute of Microbiology, Faculty of Biology, University of Warsaw, Warsaw, Poland.

Molecular epidemiological studies of Mycobacterium kansasii are hampered by the lack of highly-discriminatory genotyping modalities. The purpose of this study was to design a new, high-resolution fingerprinting method for M. kansasii. Read More

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http://dx.doi.org/10.1038/s41598-018-21562-zDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5849605PMC
March 2018
17 Reads
5.080 Impact Factor

Accuracy of Matrix-Assisted Laser Desorption Ionization-Time of Flight Mass Spectrometry for Identification of Mycobacteria: a systematic review and meta-analysis.

Sci Rep 2018 Mar 7;8(1):4131. Epub 2018 Mar 7.

Center of Laboratory Medicine, Affiliated Hospital of Nantong University, Nantong, 226000, China.

Mycobacterium species are a significant cause of morbidity and mortality worldwide. The present study was carried out to systematically evaluate the accuracy of Matrix-assisted laser desorption ionization-time of flight mass spectroscopy (MALDI-TOF MS) for the identification of clinical pathogenic mycobacteria. After a rigid selection process, 19 articles involving 2,593 mycobacteria isolates were included. Read More

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http://dx.doi.org/10.1038/s41598-018-22642-wDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5841357PMC
March 2018
9 Reads

First case of acute granulomatous interstitial nephritis with immune reconstitution inflammatory syndrome in a patient with HIV coinfected with disseminated .

BMJ Case Rep 2018 Feb 23;2018. Epub 2018 Feb 23.

Department of Infectious Diseases, University of Arizona Arizona Health Sciences Center, Tucson, Arizona, USA.

Restoration of immune response by highly active antiretroviral therapy (HAART) effectively improved the overall prognosis of HIV infection. However, 25%-31.7% of patients experience paradoxical worsening of pre-existing infections or unmasking of subclinical infections after starting HAART therapy, which is termed as immune reconstitution inflammatory syndrome (IRIS). Read More

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http://dx.doi.org/10.1136/bcr-2017-222149DOI Listing
February 2018
6 Reads

Clinical features of infection caused by non-tuberculous mycobacteria: 7 years' experience.

Infection 2018 Jun 23;46(3):357-363. Epub 2018 Feb 23.

Department of Biomedical Sciences, University of Sassari, Sassari, Italy.

Introduction: Non-tuberculous mycobacteria (NTM) are ubiquitous organisms associated with various infections. The aim of the study was to determine the most relevant clinical characteristics of NTM during the 7-year period.

Methodology: A retrospective study of NTM infections was conducted between January 2009 and December 2016. Read More

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http://dx.doi.org/10.1007/s15010-018-1128-2DOI Listing
June 2018
18 Reads