Search Our Scientific Publications & Authors

J Prim Care Community Health 2021 Jan-Dec;12:21501327211005894

Mayo Clinic, Rochester, MN, USA.

A woman in her late fifties was admitted to the Family Medicine Inpatient Service directly from Rheumatology clinic for polyarticular pain and erythema with concern for infection. She was taking immunosuppressant medications for a history of multiple autoimmune diseases. Examination showed increasing erythema and tenderness on the upper and lower extremity joints. Read More

Int J Dermatol 2021 Mar 9. Epub 2021 Mar 9.

Department of Dermatology, University of Maryland School of Medicine, Baltimore, MD, USA.

Int J Dermatol 2021 Mar 2. Epub 2021 Mar 2.

Department of Dermatology, Changi General Hospital, Singapore.

BMC Infect Dis 2021 Jan 7;21(1):27. Epub 2021 Jan 7.

Division of Infectious Diseases and Tropical Medicine, Department of Medicine, Faculty of Medicine Siriraj Hospital, Mahidol University, 2 Wanglang Road, Bangkoknoi, Bangkok, 10700, Thailand.

Background: Ruxolitinib is a novel oral Janus kinase inhibitor that is used for treatment of myeloproliferative diseases. It exhibits potent anti-inflammatory and immunosuppressive effects, and may increase the risk of opportunistic infections. Here, we report a rare case of Cryptococcus neoformans and Mycobacterium haemophilum coinfection in a myelofibrosis patient who was receiving ruxolitinib. Read More

J Clin Tuberc Other Mycobact Dis 2020 Dec 19;21:100197. Epub 2020 Oct 19.

The University of Kansas Medical Center, Department of Internal Medicine, Division of Infectious Diseases, Kansas City, KS, United States.

Mycobacterium haemophilum is a slow growing nontuberculous mycobacterium which prefers cooler temperatures and requires iron for growth. It usually causes skin and soft tissue infections in immunocompromised hosts and cervical lymphadenitis in healthy children. We present the case of fatal disseminated M. Read More

BMC Infect Dis 2020 Nov 23;20(1):877. Epub 2020 Nov 23.

Department of Ophthalmology, Faculty of Medicine, Siriraj Hospital, Mahidol University, 2 Wanglang Road, Bangkok Noi, Bangkok, 10700, Thailand.

Background: To report three cases of nontuberculous mycobacterial (NTM) endophthalmitis following multiple ocular surgeries and to review previous literature in order to study the clinical profile, treatment modalities, and visual outcomes among patients with NTM endophthalmitis.

Methods: Clinical manifestation and management of patients with NTM endophthalmitis in the Department of Ophthalmology, Faculty of Medicine, Siriraj hospital, Mahidol University, Bangkok, Thailand were described. In addition, a review of previously reported cases and case series from MEDLINE, EMBASE, and CENTRAL was performed. Read More

Case Reports Plast Surg Hand Surg 2020 Oct 13;7(1):116-119. Epub 2020 Oct 13.

Department of Orthopaedic Surgery, Osaka City University Graduate School of Medicine, Osaka, Japan.

We report a case of purulent flexor tenosynovitis caused by in an immunosuppressed patient who received renal transplantation. Three synovial debridements and multiple antimicrobial administrations with clarithromycin, rifampicin, and moxifloxacin have been performed. No apparent recurrence has been observed two years after the final operation. Read More

BMC Ophthalmol 2020 Sep 23;20(1):378. Epub 2020 Sep 23.

Department of Ophthalmology, Faculty of Medicine Ramathibodi Hospital, Mahidol University, Rama VI Rd., Rajathevi, Bangkok, 10400, Thailand.

Background: Mycobacterium haemophilum is a rare and emerging nontuberculous mycobacteria (NTM). It normally causes localized or disseminated systemic diseases, particularly skin infections and arthritis in severely immunocompromised patients. There have been 5 cases of M. Read More

J Dtsch Dermatol Ges 2020 Oct 14;18(10):1186-1188. Epub 2020 Jul 14.

Shandong Provincial Hospital for Skin Diseases & Shandong Provincial Institute of Dermatology and Veneorology, Shandong First Medical University & Shandong Academy of Medical Sciences, Jinan, China.

Acta Neuropathol Commun 2020 05 19;8(1):73. Epub 2020 May 19.

Department of Pathology & Cell Biology, Columbia University Irving Medical Center, New York, NY, 10032, USA.

Infections by opportunistic non-tuberculous mycobacteria (NTM) are rising in global incidence. One emerging, slowly growing NTM is Mycobacterium haemophilum, which can cause skin, lung, bone, and soft tissue infections in immunocompromised patients as well as lymphadenitis in immunocompetent individuals. Detection of this microorganism is difficult using conventional culture-based methods and few reports have documented involvement of this pathogen within the central nervous system (CNS). Read More

Transpl Infect Dis 2020 Oct 23;22(5):e13315. Epub 2020 May 23.

Division of Infectious Diseases, Department of Medicine, Faculty of Medicine Ramathibodi Hospital, Mahidol University, Bangkok, Thailand.

Non-tuberculous mycobacteria are ubiquitous pathogens causing infections in immunocompromised patients. Here, we describe a kidney transplant recipient who developed skin and soft tissue infection by Mycobacterium haemophilum, complicated by tenosynovitis and fluid collection, following an injury sustained to her right foot. Her immunosuppressant dose was reduced, and she underwent prolonged antimicrobial therapy followed by surgical debridement with a favorable outcome. Read More

Dig Liver Dis 2020 09 24;52(9):1057-1058. Epub 2020 Apr 24.

School of Medicine, Chung Shan Medical University, Taichung, Taiwan; Endoscopy Center, Changhua Christian Hospital, 500 Nanhsiao Street, Changhua, Taiwan. Electronic address:

J Fish Dis 2020 Jun 14;43(6):637-650. Epub 2020 Apr 14.

Zebrafish International Resource Center, Eugene, Oregon.

The use of zebrafish (Danio rerio) in biomedical research has expanded at a tremendous rate over the last two decades. Along with increases in laboratories using this model, we are discovering new and important diseases. We review here the important pathogens and diseases based on some 20 years of research and findings from our diagnostic service at the NIH-funded Zebrafish International Resource Center. Read More

J Clin Rheumatol 2020 Apr 2. Epub 2020 Apr 2.

From the Department of Dermatology, The First Affiliated Hospital of Nanjing Medical University.

Pediatr Infect Dis J 2020 08;39(8):671-677

Gallipoli Medical Research Institute, University of Queensland, Brisbane, Australia.

Background: Nontuberculous mycobacteria (NTM) are ubiquitous in the environment and a well-known cause of lymphadenitis, skin and soft tissue infections. The aim of this study was to evaluate the epidemiology of extrapulmonary pediatric NTM infections occurring from 2000 to 2017 in Queensland, Australia.

Methods: All cases of NTM and TB are notifiable under the Queensland Public Health Act (2005) and associated regulations (2005). Read More

IDCases 2020 22;19:e00674. Epub 2019 Nov 22.

University of Colorado School of Medicine 12700 E. 19th Avenue, Mail Stop B168, Aurora, CO 80045, USA.

is a slow growing acid-fast bacillus (AFB) in the nontuberculous mycobacteria (NTM) group. typically causes cervicofacial lymphadenitis in children, cutaneous diseases, septic arthritis and osteomyelitis. However, it rarely causes isolated spinal cord disease. Read More

Medicine (Baltimore) 2020 Mar;99(10):e19355

Division of Dermatology, Faculty of Medicine Ramathibodi Hospital, Mahidol University, Bangkok, Thailand.

A remarkable increase in the prevalence of cutaneous nontuberculous mycobacterial (NTM) infection has occurred worldwide. However, updated data regarding cutaneous NTM infection in Thailand is limited.This study aim to describe the clinical manifestations, pathogenic organism, and prognostic factors of cutaneous NTM infections among patients living in Thailand. Read More

Indian J Dermatol Venereol Leprol 2020 Mar-Apr;86(2):181-184

Department of Dermatovenereology, West China Hospital, Sichuan University, Chengdu, Sichuan, China.

J Clin Rheumatol 2021 Jan;27(1):e36-e37

Division of Division of Allergy and Infectious Diseases, Department of Medicine, University of Washington, Seattle, WA.

Rev Inst Med Trop Sao Paulo 2019 20;61:e71. Epub 2019 Dec 20.

Fundação Oswaldo Cruz, Laboratório de Biologia Molecular Aplicada a Micobactérias, Rio de Janeiro, Rio de Janeiro, Brazil.

Mycobacterium haemophilum is a nontuberculous mycobacterium that causes localized or disseminated disease, mainly in immunocompromised hosts. We report the case of a 35-year-old HIV-infected woman who presented with several enlarging cutaneous lesions over the arms and legs. Histopathological examination revealed the diagnosis of a cutaneous mycobacterial disease. Read More

J Korean Med Sci 2019 Dec 2;34(46):e302. Epub 2019 Dec 2.

Department of Pediatrics, Seoul National University Bundang Hospital, Seoul National University College of Medicine, Seongnam, Korea.

Background: Nontuberculous mycobacteria (NTM) lymphadenitis is an under-recognized entity, and data of the true burden in children are limited. Without a high index of suspicion, diagnosis may be delayed and microbiological detection is challenging. Here, we report a cluster of NTM lymphadenitis experienced in Korean children. Read More

Cutis 2019 Oct;104(4):238-241

Southwest Skin Specialists, Phoenix, Arizona, USA.

Mycobacterium haemophilum is a nontuberculous organism that commonly manifests as cutaneous lesions and subcutaneous nodules in immunosuppressed adults. Because M haemophilum infection is rare, the epidemiology, reservoir, and mode of transmission remain largely unknown. Infection presents a challenge to the dermatology community because it is infrequently suspected and commonly misidentified, resulting in delayed diagnosis. Read More

BMJ Case Rep 2019 Nov 21;12(11). Epub 2019 Nov 21.

Internal Medicine, Rush University, Chicago, Illinois, USA.

is a rare pathogen, predominately present in the immunocompromised population. It is especially studied in HIV and haematological malignancy patients. Given its unique living conditions, it is often difficult to establish its diagnosis, but it is often suspected by its classic association with ulcerating skin findings. Read More

Cutis 2019 Sep;104(3):E7-E10

Department of Medicine, Division of Infectious Diseases, Thomas Jefferson University, Philadelphia, Pennsylvania, USA.

Emerg Infect Dis 2019 09;25(9):1648-1652

Mycobacterium haemophilum is a nontuberculous mycobacterium that can infect immunocompromised patients. Because of special conditions required for its culture, this bacterium is rarely reported and there are scarce data for long-term outcomes. We conducted a retrospective study at Siriraj Hospital, Bangkok, Thailand, during January 2012-September 2017. Read More

Rheumatol Int 2019 Oct 27;39(10):1783-1787. Epub 2019 Jul 27.

Division of Rheumatology, Department of Medicine, Faculty of Medicine, Siriraj Hospital, Mahidol University, 2 Wanglang Road, Bangkok Noi, Bangkok, 10700, Thailand.

To investigate the clinical manifestations and outcomes of musculoskeletal (MSK) nontuberculous mycobacterium (NTM) infections. This study was a retrospective cohort study using the Siriraj Hospital database from 2005 to 2017. Enrolled were all patients aged 15 or older who had an MSK infection with NTM identified in synovial fluid, pus, or tissue by an acid-fast bacilli stain, culture, or polymerase chain reaction. Read More

Surg Infect (Larchmt) 2019 Sep 8;20(6):492-498. Epub 2019 May 8.

2School of Medicine, National Yang-Ming University, Taipei, Taiwan, Republic of China.

The incidence of non-tuberculous mycobacterial (NTM) infections of the skin, soft tissue, and musculoskeletal system (SSTI) has increased over the past two decades, however, relatively few studies have documented the reasons for the reported increase. Specifically, no standardized treatment protocols have been adopted, therefore, clinical prognosis of the patients with NTM SSTI has thus far remained uncertain. In our study, we sought to identify risk factors for treatment failure in southern Taiwan. Read More

J Dermatol 2019 09 2;46(9):e319-e320. Epub 2019 Apr 2.

Dermatology Department of Integrated Medicine, Graduate School of Medicine, Osaka University, Suita, Japan.

J Clin Microbiol 2019 02 30;57(2). Epub 2019 Jan 30.

Department of Mycobacteriology, Leprosy Research Center, National Institute of Infectious Diseases, Tokyo, Japan

Clin Microbiol Rev 2018 01 14;32(1). Epub 2018 Nov 14.

Servicio de Dermatología y Departamento de Micología, Hospital General de México, Mexico City, Mexico.

Humans encounter mycobacterial species due to their ubiquity in different environmental niches. In many individuals, pathogenic mycobacterial species may breach our first-line barrier defenses of the innate immune system and modulate the activation of phagocytes to cause disease of the respiratory tract or the skin and soft tissues, sometimes resulting in disseminated infection. Cutaneous mycobacterial infections may cause a wide range of clinical manifestations, which are divided into four main disease categories: (i) cutaneous manifestations of infection, (ii) Buruli ulcer caused by and other related slowly growing mycobacteria, (iii) leprosy caused by and , and (iv) cutaneous infections caused by rapidly growing mycobacteria. Read More