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Microbiol Spectr 2022 Apr 25:e0169221. Epub 2022 Apr 25.

Department of Laboratory Medicine, The University of Texas MD Anderson Cancer Center, Houston, Texas, USA.

Leprosy is caused by Mycobacterium leprae and Mycobacterium . We report construction and analyses of the complete genome sequence of FJ924. The genome contained 3,271,694 nucleotides to encode 1,789 functional genes and 1,564 pseudogenes. Read More

Microbes Environ 2022 ;37(1)

Department of Urban Engineering, Graduate School of Engineering, The University of Tokyo.

In premise plumbing, microbial water quality may deteriorate under certain conditions, such as stagnation. Stagnation results in a loss of disinfectant residual, which may lead to the regrowth of microorganisms, including opportunistic pathogens. In the present study, microbial regrowth was investigated at eight faucets in a building over four seasons in one year. Read More

Open Forum Infect Dis 2022 Apr 11;9(4):ofac074. Epub 2022 Feb 11.

Department of Infectious Diseases, The University of Tokyo Hospital, Tokyo, Japan.

is a nontuberculous mycobacteria (NTM) with a predilection for skin and soft tissue infection (SSTI) in the immunocompromised host. We report a case of disseminated infection initially presenting as a nonresolving subacute cellulitis of bilateral lower extremities. Genetic sequencing was used for final identification, while a commercially available polymerase chain reaction test returned a false-positive result for . Read More

BMJ Case Rep 2022 Jan 17;15(1). Epub 2022 Jan 17.

College of Medicine, University of Saskatchewan, Saskatoon, Saskatchewan, Canada

is a rarely encountered pathogen that is difficult to identify given its unique growth requirements. It is most often seen in adult patients who are immunosuppressed due to advanced HIV or haematological malignancy. Our case highlights a typical presentation of an atypical pathogen in a patient with rheumatoid arthritis receiving anti-tumour necrosis factor therapy. Read More

Z Rheumatol 2021 Nov 26. Epub 2021 Nov 26.

Abteilung Rheumatologie, Klinische Immunologie und Osteologie - Standort Wannsee, Immanuel Krankenhaus Berlin - Klinik für Innere Medizin, Berlin, Deutschland.

Mycobacterium haemophilum is a rare pathogen belonging to the group of slowly growing nontuberculous mycobacteria (NTM) that can cause infections, especially in immunocompromised patients. Detection by culturing is difficult because M. haemophilum only grows under special cultivation conditions. Read More

Dermatol Online J 2021 Jun 15;27(6). Epub 2021 Jun 15.

Department of Dermatology, The University of Texas MD Anderson Cancer Center, Houston, TX.

Nontuberculous mycobacteria are pathogens with diverse manifestations in immunocompromised hosts. The lesser-known Mycobacterium haemophilum usually causes cutaneous infection. Diagnosis is challenging but is aided by molecular testing and multidisciplinary communication. Read More

Am J Trop Med Hyg 2021 07 8;105(3):633-637. Epub 2021 Jul 8.

2Tuberculosis Biomarker Research Unit, Centro de Biología Molecular y Celular de Enfermedades (CBCME) del Instituto de Investigaciones Científicas y Servicios de Alta Tecnología (INDICASAT-AIP), Ciudad del Saber, Panamá.

Mycobacterium tuberculosis (MTB) stands out as the main causative agent of pulmonary tuberculosis (TB). However, nontuberculous mycobacteria (NTM) species also have the potential to infect and cause TB in susceptible individuals. The objective of this study was to identify NTM species that cause public health problems in remote areas. Read More

Lancet Infect Dis 2021 06;21(6):887

Hematology and Rheumatology Department, Chengdu Second People's Hospital, Chengdu, China. Electronic address:

Interdiscip Sci 2021 Jun 19;13(2):334-343. Epub 2021 May 19.

Instituto de Investigação e Inovação em Saúde (I3S), Universidade do Porto, Rua Alfredo Allen, 208, 4200-135, Porto, Portugal.

The identification of clinically relevant bacterial amino acid changes can be performed using different methods aimed at the identification of genes showing positively selected amino acid sites (PSS). Nevertheless, such analyses are time consuming, and the frequency of genes showing evidence for PSS can be low. Therefore, the development of a pipeline that allows the quick and efficient identification of the set of genes that show PSS is of interest. Read More

J Prim Care Community Health 2021 Jan-Dec;12:21501327211005894

Mayo Clinic, Rochester, MN, USA.

A woman in her late fifties was admitted to the Family Medicine Inpatient Service directly from Rheumatology clinic for polyarticular pain and erythema with concern for infection. She was taking immunosuppressant medications for a history of multiple autoimmune diseases. Examination showed increasing erythema and tenderness on the upper and lower extremity joints. Read More

Int J Dermatol 2021 Sep 9;60(9):1174-1175. Epub 2021 Mar 9.

Department of Dermatology, University of Maryland School of Medicine, Baltimore, MD, USA.

Int J Dermatol 2021 Aug 2;60(8):e309-e311. Epub 2021 Mar 2.

Department of Dermatology, Changi General Hospital, Singapore.

BMC Infect Dis 2021 Jan 7;21(1):27. Epub 2021 Jan 7.

Division of Infectious Diseases and Tropical Medicine, Department of Medicine, Faculty of Medicine Siriraj Hospital, Mahidol University, 2 Wanglang Road, Bangkoknoi, Bangkok, 10700, Thailand.

Background: Ruxolitinib is a novel oral Janus kinase inhibitor that is used for treatment of myeloproliferative diseases. It exhibits potent anti-inflammatory and immunosuppressive effects, and may increase the risk of opportunistic infections. Here, we report a rare case of Cryptococcus neoformans and Mycobacterium haemophilum coinfection in a myelofibrosis patient who was receiving ruxolitinib. Read More

J Clin Tuberc Other Mycobact Dis 2020 Dec 19;21:100197. Epub 2020 Oct 19.

The University of Kansas Medical Center, Department of Internal Medicine, Division of Infectious Diseases, Kansas City, KS, United States.

Mycobacterium haemophilum is a slow growing nontuberculous mycobacterium which prefers cooler temperatures and requires iron for growth. It usually causes skin and soft tissue infections in immunocompromised hosts and cervical lymphadenitis in healthy children. We present the case of fatal disseminated M. Read More

BMC Infect Dis 2020 Nov 23;20(1):877. Epub 2020 Nov 23.

Department of Ophthalmology, Faculty of Medicine, Siriraj Hospital, Mahidol University, 2 Wanglang Road, Bangkok Noi, Bangkok, 10700, Thailand.

Background: To report three cases of nontuberculous mycobacterial (NTM) endophthalmitis following multiple ocular surgeries and to review previous literature in order to study the clinical profile, treatment modalities, and visual outcomes among patients with NTM endophthalmitis.

Methods: Clinical manifestation and management of patients with NTM endophthalmitis in the Department of Ophthalmology, Faculty of Medicine, Siriraj hospital, Mahidol University, Bangkok, Thailand were described. In addition, a review of previously reported cases and case series from MEDLINE, EMBASE, and CENTRAL was performed. Read More

Case Reports Plast Surg Hand Surg 2020 Oct 13;7(1):116-119. Epub 2020 Oct 13.

Department of Orthopaedic Surgery, Osaka City University Graduate School of Medicine, Osaka, Japan.

We report a case of purulent flexor tenosynovitis caused by in an immunosuppressed patient who received renal transplantation. Three synovial debridements and multiple antimicrobial administrations with clarithromycin, rifampicin, and moxifloxacin have been performed. No apparent recurrence has been observed two years after the final operation. Read More

BMC Ophthalmol 2020 Sep 23;20(1):378. Epub 2020 Sep 23.

Department of Ophthalmology, Faculty of Medicine Ramathibodi Hospital, Mahidol University, Rama VI Rd., Rajathevi, Bangkok, 10400, Thailand.

Background: Mycobacterium haemophilum is a rare and emerging nontuberculous mycobacteria (NTM). It normally causes localized or disseminated systemic diseases, particularly skin infections and arthritis in severely immunocompromised patients. There have been 5 cases of M. Read More

J Dtsch Dermatol Ges 2020 Oct 14;18(10):1186-1188. Epub 2020 Jul 14.

Shandong Provincial Hospital for Skin Diseases & Shandong Provincial Institute of Dermatology and Veneorology, Shandong First Medical University & Shandong Academy of Medical Sciences, Jinan, China.

Acta Neuropathol Commun 2020 05 19;8(1):73. Epub 2020 May 19.

Department of Pathology & Cell Biology, Columbia University Irving Medical Center, New York, NY, 10032, USA.

Infections by opportunistic non-tuberculous mycobacteria (NTM) are rising in global incidence. One emerging, slowly growing NTM is Mycobacterium haemophilum, which can cause skin, lung, bone, and soft tissue infections in immunocompromised patients as well as lymphadenitis in immunocompetent individuals. Detection of this microorganism is difficult using conventional culture-based methods and few reports have documented involvement of this pathogen within the central nervous system (CNS). Read More

Transpl Infect Dis 2020 Oct 23;22(5):e13315. Epub 2020 May 23.

Division of Infectious Diseases, Department of Medicine, Faculty of Medicine Ramathibodi Hospital, Mahidol University, Bangkok, Thailand.

Non-tuberculous mycobacteria are ubiquitous pathogens causing infections in immunocompromised patients. Here, we describe a kidney transplant recipient who developed skin and soft tissue infection by Mycobacterium haemophilum, complicated by tenosynovitis and fluid collection, following an injury sustained to her right foot. Her immunosuppressant dose was reduced, and she underwent prolonged antimicrobial therapy followed by surgical debridement with a favorable outcome. Read More

Dig Liver Dis 2020 09 24;52(9):1057-1058. Epub 2020 Apr 24.

School of Medicine, Chung Shan Medical University, Taichung, Taiwan; Endoscopy Center, Changhua Christian Hospital, 500 Nanhsiao Street, Changhua, Taiwan. Electronic address:

J Fish Dis 2020 Jun 14;43(6):637-650. Epub 2020 Apr 14.

Zebrafish International Resource Center, Eugene, Oregon.

The use of zebrafish (Danio rerio) in biomedical research has expanded at a tremendous rate over the last two decades. Along with increases in laboratories using this model, we are discovering new and important diseases. We review here the important pathogens and diseases based on some 20 years of research and findings from our diagnostic service at the NIH-funded Zebrafish International Resource Center. Read More

J Clin Rheumatol 2021 Aug;27(5):e198-e199

From the Department of Dermatology, The First Affiliated Hospital of Nanjing Medical University.

Pediatr Infect Dis J 2020 08;39(8):671-677

Gallipoli Medical Research Institute, University of Queensland, Brisbane, Australia.

Background: Nontuberculous mycobacteria (NTM) are ubiquitous in the environment and a well-known cause of lymphadenitis, skin and soft tissue infections. The aim of this study was to evaluate the epidemiology of extrapulmonary pediatric NTM infections occurring from 2000 to 2017 in Queensland, Australia.

Methods: All cases of NTM and TB are notifiable under the Queensland Public Health Act (2005) and associated regulations (2005). Read More

IDCases 2020 22;19:e00674. Epub 2019 Nov 22.

University of Colorado School of Medicine 12700 E. 19th Avenue, Mail Stop B168, Aurora, CO 80045, USA.

is a slow growing acid-fast bacillus (AFB) in the nontuberculous mycobacteria (NTM) group. typically causes cervicofacial lymphadenitis in children, cutaneous diseases, septic arthritis and osteomyelitis. However, it rarely causes isolated spinal cord disease. Read More

Medicine (Baltimore) 2020 Mar;99(10):e19355

Division of Dermatology, Faculty of Medicine Ramathibodi Hospital, Mahidol University, Bangkok, Thailand.

A remarkable increase in the prevalence of cutaneous nontuberculous mycobacterial (NTM) infection has occurred worldwide. However, updated data regarding cutaneous NTM infection in Thailand is limited.This study aim to describe the clinical manifestations, pathogenic organism, and prognostic factors of cutaneous NTM infections among patients living in Thailand. Read More

Indian J Dermatol Venereol Leprol 2020 Mar-Apr;86(2):181-184

Department of Dermatovenereology, West China Hospital, Sichuan University, Chengdu, Sichuan, China.

J Clin Rheumatol 2021 Jan;27(1):e36-e37

Division of Division of Allergy and Infectious Diseases, Department of Medicine, University of Washington, Seattle, WA.

Rev Inst Med Trop Sao Paulo 2019 20;61:e71. Epub 2019 Dec 20.

Fundação Oswaldo Cruz, Laboratório de Biologia Molecular Aplicada a Micobactérias, Rio de Janeiro, Rio de Janeiro, Brazil.

Mycobacterium haemophilum is a nontuberculous mycobacterium that causes localized or disseminated disease, mainly in immunocompromised hosts. We report the case of a 35-year-old HIV-infected woman who presented with several enlarging cutaneous lesions over the arms and legs. Histopathological examination revealed the diagnosis of a cutaneous mycobacterial disease. Read More

J Korean Med Sci 2019 Dec 2;34(46):e302. Epub 2019 Dec 2.

Department of Pediatrics, Seoul National University Bundang Hospital, Seoul National University College of Medicine, Seongnam, Korea.

Background: Nontuberculous mycobacteria (NTM) lymphadenitis is an under-recognized entity, and data of the true burden in children are limited. Without a high index of suspicion, diagnosis may be delayed and microbiological detection is challenging. Here, we report a cluster of NTM lymphadenitis experienced in Korean children. Read More