Search our Database of Scientific Publications and Authors

I’m looking for a

    11963 results match your criteria Mycobacterium Gordonae

    1 OF 240

    Positive Effect of Liposomal Amikacin for Inhalation onin Cystic Fibrosis Patients.
    Open Forum Infect Dis 2018 Mar 17;5(3):ofy034. Epub 2018 Feb 17.
    Cystic Fibrosis Center, Hôpital Arnaud de Villeneuve, Centre Hospitalier Universitaire de Montpellier, Univ Montpellier, France.
    is difficult to eradicate. At the Montpellier CF Center, we prescribed liposomal amikacin for inhalation to 5 patients withinfection. The 3 patients who completed the treatment did not have any respiratory exacerbation, showed negative cultures forin their sputum, and stabilized their spirometric functions. Read More

    Prevalence of Opportunistic Infections and Causes of Death among Hospitalized HIV-Infected Patients in Sichuan, China.
    Tohoku J Exp Med 2018 ;244(3):231-242
    Department of West China School of Public Health, No.4 West China Teaching Hospital, Sichuan University.
    Opportunistic infections (OIs) are the most significant complication of human immunodeficiency virus (HIV) infection. The prevalence of OIs differs among various countries in part due to different climates and socio-economic conditions. We, therefore, carried out the retrospective study at the Public Health Clinical Center of Chengdu, Sichuan to comprehensively investigate the prevalence of OIs, predictors of OIs, and risk factors for in-hospital death among HIV-infected patients. Read More

    Paradigm for diagnosing mycobacterial disease: direct detection and differentiation ofcomplex and non-tuberculous mycobacteria in clinical specimens using multiplex real-time PCR.
    J Clin Pathol 2018 Mar 20. Epub 2018 Mar 20.
    Department of Laboratory Medicine, Gangneung Asan Hospital, University of Ulsan College of Medicine, Gangneung, Korea.
    Aims: and non-tuberculous mycobacteria (NTM) are clinically different, and the rapid detection and differentiation ofcomplex (MTBC) and NTM is crucial for patient management and infection control. Given the slow growth of most pathogenic mycobacteria, nucleic acid amplification assays are excellent tools for direct identification of mycobacteria in clinical specimens. Recently, a multiplex real-time PCR assay was developed that can directly detect 20 mycobacterial species in clinical specimens. Read More

    Skin and Soft Tissue Infections Due to Nontuberculous Mycobacteria.
    Curr Infect Dis Rep 2018 Mar 19;20(4). Epub 2018 Mar 19.
    Division of Infectious Disease, Department of Pediatrics, School of Medicine and Public Health, University of Wisconsin, Madison, WI, USA.
    Purpose Of Review: This review describes recent trends in the epidemiology of nontuberculous mycobacteria (NTM), emerging pathogens, new insights into NTM pathogenesis, and advances in diagnosis and treatment.

    Recent Findings: Emerging pathogens include Mycobacterium chimaera and drug-resistant subspecies of Mycobacterium abscessus. Important virulence mechanisms of pathogenic NTM include the ability to alter the macrophage's permissiveness to intracellular bacterial growth. Read More

    Marine Develops Chronic Right Knee Granuloma After Initial Injury at The Basic School.
    Mil Med 2018 Mar 14. Epub 2018 Mar 14.
    Department of Dermatology, Naval Hospital Camp Pendleton, 200 Mercy Ct, Camp Pendleton, CA 92055.
    With skin lesions that have failed previous treatments, consideration for an atypical mycobacteria, specifically Mycobacterium marinum, infection should be suspected. Importance of the history cannot be stressed as this is a clue that the patient may have been inoculated and infected in the field environment. A marine with chronic right knee plaque for 3 yr that first appeared after a field exercise at The Basic School but worsened despite treatment with clindamycin, TMP-SMX, and incision and drainage in 2012. Read More

    Performance of a Highly-SensitiveComplex Real-time PCR Assay for the Diagnosis of Pulmonary Tuberculosis in a Low Prevalence Setting: A Prospective Intervention Study.
    J Clin Microbiol 2018 Mar 14. Epub 2018 Mar 14.
    Microbiology Service, Hospital Clínico Universitario, Instituto de Investigación INCLIVA, Valencia, Spain
    The potential impact of routine real-time PCR testing of respiratory specimens from patients with presumptive tuberculosis in terms of diagnostic accuracy and time to tuberculosis treatment inception in low-prevalence settings remains largely unexplored. We conducted a prospective intervention cohort study. Respiratory specimens from 1,020 patients were examined by acid-fast bacilli smear microscopy, tested by the real-timecomplex PCR assay (Abbott RealTiMTB PCR) and cultured in mycobacterial media. Read More

    Performance of Sequencing in Predicting Ofloxacin Resistance infrom Positive Bactec MGIT 960 Cultures.
    Ann Clin Lab Sci 2018 Jan;48(1):69-74
    Tuberculosis Reference Laboratory, Tianjin Center for Tuberculosis Control, Tianjin, China.
    Ofloxacin (OFX) resistant(MTB) isolates have been increasingly observed worldwide, complicating tuberculosis control. This study investigated the performance of sequencing which could predict OFX resistance in MTB isolates from positive Bactec MGIT 960 cultures. A total of 214 Bactec MGIT 960 positive cultures were identified by p-nitrobenzoic-acid and thiophene-2-carboxylic hydrazide. Read More

    Utilization of molecular and conventional methods for the identification of nontuberculous mycobacteria isolated from different water sources.
    Int J Mycobacteriol 2018 Jan-Mar;7(1):53-60
    Laboratory of Mycobacteria, Faculty of Veterinary Sciences, National University of La Pampa, General Pico, La Pampa, Argentina.
    Background: The environment is the nontuberculous mycobacteria (NTM) reservoir, opportunistic pathogens of great diversity and ubiquity, which is observed in the constant description of new species capable of causing infection. Since its introduction, molecular methods are essential for species identification. Most comparative studies between molecular and conventional methods, have used isolated strains from clinical samples. Read More

    activity of seven hospital biocides against: Implications for patients with cystic fibrosis.
    Int J Mycobacteriol 2018 Jan-Mar;7(1):45-47
    Regional Adult Cystic Fibrosis Centre, Belfast City Hospital, Northern Ireland, UK.
    Background: Mycobacterium abscessus pulmonary infection has recently emerged as a significant pathogen in patients with cystic fibrosis (CF) and is associated with significant morbidity and accelerated pulmonary decline. There is a paucity of data describing the activity of hospital biocides against this organism.

    Methods: M. Read More

    [Italian Cystic Fibrosis Registry. Report 2011-2014].
    Epidemiol Prev 2018 Jan-Feb;42(1S1):1-32
    Centro nazionale malattie rare, Istituto superiore di sanità, Roma.
    Introduction: The Italian Cystic Fibrosis Registry (ICFR) is based on a new agreement about the data flow towards the Registry signed on October, 4th 2016 by the Centre for Rare Diseases of the Italian National Institute of Health (NIH), the clinicians of the Italian National Referral and Support Centres for Cystic Fibrosis, the Paediatric Hospital "Bambino Gesù" (Rome), the Italian Cystic Fibrosis Society, and the Italian League for Cystic Fibrosis.

    Objectives: The aim of the present Report is to improve the knowledge on cystic fibrosis (CF) through the epidemiological description of Italian patients. The members of the Scientific and Technical Committee have to write a report on data collected by ICFR, in order to contribute to achieve the aims of ICFR itself, i. Read More

    Mycobacterium heckeshornense lung infection diagnosed by matrix-assisted laser desorption ionization-time of flight mass spectrometry (MALDI-TOF MS).
    J Infect Chemother 2018 Mar 1. Epub 2018 Mar 1.
    Department of Respiratory Medicine, The University of Tokyo, Japan.
    Identification of microorganisms by matrix-assisted laser desorption ionization-time of flight mass spectrometry (MALDI-TOF MS) has been widely accepted. However, the significance of MALDI-TOF MS for identifying mycobacteria, particularly rare nontuberculous mycobacteria, has not been established. M. Read More

    Nontuberculous mycobacterial lung disease in a patient with COPD and bronchiectasis, with radiological signs of lung tumor.
    Adv Respir Med 2018 ;86(1):17-22
    Instytut Grużicy i Chorób Płuc, UL. Płocka 26, 01-138 Warszawa, Poland.
    Mycobacterial lung disease is caused by nontuberculous mycobacteria (NTM), also known as atypical mycobacteria. NTM are widely distributed in the environment, particularly in soil and water; they may colonize the airways, gastrointestinal tract and genitourinary system, without the apparent signs of disease. Nevertheless, in some risk groups such as patients with chronic lung diseases or with immunodeficiency, mycobacterial lung disease is identified. Read More

    The many lives of nontuberculous mycobacteria.
    J Bacteriol 2018 Feb 26. Epub 2018 Feb 26.
    Department of Microbiology and Immunology, Medical College of Wisconsin, Milwaukee, Wisconsin, USA.
    Nontuberculous mycobacteria (NTM) include species that colonize human epithelia, as well as species that are ubiquitous in soil and aquatic environments. NTM that primarily inhabit soil and aquatic environments include thecomplex (MAC,and) and thecomplex (MABSC,subspecies,, and), and can be free-living, biofilm-associated, or amoeba-associated. Although NTM are rarely pathogenic in immunocompetent individuals, those who are immunocompromised - due to either an inherited or acquired immunodeficiency - are highly susceptible to NTM infection (NTMI). Read More

    TNF-α-mediated ER stress causes elimination of Mycobacterium fortuitum reservoirs by macrophage apoptosis.
    FASEB J 2018 Feb 26:fj201701407R. Epub 2018 Feb 26.
    Department of Microbiology, College of Medicine, Chungnam National University, Daejeon, South Korea.
    Mycobacterium fortuitum (MF), a rapidly growing nontuberculosis mycobacterium, is recognized as an important human pathogen. We investigated whether the endoplasmic reticulum (ER) stress response is associated with the apoptosis of MF-infected macrophages. The expression of ER molecular chaperones was significantly induced by MF infection. Read More

    Clinical features of infection caused by non-tuberculous mycobacteria: 7 years' experience.
    Infection 2018 Feb 23. Epub 2018 Feb 23.
    Department of Biomedical Sciences, University of Sassari, Sassari, Italy.
    Introduction: Non-tuberculous mycobacteria (NTM) are ubiquitous organisms associated with various infections. The aim of the study was to determine the most relevant clinical characteristics of NTM during the 7-year period.

    Methodology: A retrospective study of NTM infections was conducted between January 2009 and December 2016. Read More

    Cutaneous infection due to Mycobacterium immunogenum: an European case report and review of the literature.
    Dermatol Online J 2017 Oct 15;23(10). Epub 2017 Oct 15.
    Department of Dermatology, Hospital Universitario Fundacion Alcorcon, Madrid, Spain.
    (no more than 200 words): In the last few years, the incidence of cutaneous infections caused by nontuberculous mycobacteria is increasing. Since Mycobacterium immunogenum was first described in 2001, few case reports have been described, all of them in the American continent. We report a case with cutaneous infection caused by this newly discovered NTB in Europe. Read More

    Increasing Prevalence of Nontuberculous Mycobacteria in Respiratory Specimens from US-Affiliated Pacific Island Jurisdictions.
    Emerg Infect Dis 2018 Mar;24(3):485-491
    Nontuberculous mycobacteria (NTM) respiratory infections represent a growing public health problem in many countries. However, there are limited published epidemiologic studies for the Western Pacific region. We reviewed respiratory specimens submitted to Diagnostic Laboratory Services in Hawaii, USA, for culture of Mycobacterium tuberculosis during August 2007-December 2011 to determine the NTM isolation rate. Read More

    Antimicrobial activity against Mycobacterium tuberculosis under in vitro lipid-rich dormancy conditions.
    J Med Microbiol 2018 Mar 15;67(3):282-285. Epub 2018 Jan 15.
    1​Departamento de Microbiología, Escuela Nacional de Ciencias Biológicas, Instituto Politécnico Nacional, Mexico City, 11340, Mexico.
    Although tuberculosis treatment is dependent on drug-susceptibility testing (DST) and molecular drug-resistance detection, treatment failure and relapse remain a challenge. This could be partially due to the emergence of antibiotic-tolerant dormant mycobacteria, where host lipids have been shown to play an important role. This study evaluated the susceptibility of Mycobacterium tuberculosis to two antibiotic combinations - rifampicin, moxifloxacin, amikacin and metronidazole (RIF-MXF-AMK-MTZ), and rifampicin, moxifloxacin, amikacin and pretomanid (RIF-MXF-AMK-PA) - in a lipid-rich dormancy model. Read More

    Nontuberculous mycobacteria in milk from positive cows in the intradermal comparative cervical tuberculin test: implications for human tuberculosis infections.
    Rev Inst Med Trop Sao Paulo 2018 15;60:e6. Epub 2018 Feb 15.
    Departamento de Higiene Veterinária e Saúde Pública, Faculdade de Medicina Veterinária e Zootecnia, Universidade Estadual Paulista, Botucatu, São Paulo, Brazil.
    Although the tuberculin test represents the main in vivo diagnostic method used in the control and eradication of bovine tuberculosis, few studies have focused on the identification of mycobacteria in the milk from cows positive to the tuberculin test. The aim of this study was to identify Mycobacterium species in milk samples from cows positive to the comparative intradermal test. Milk samples from 142 cows positive to the comparative intradermal test carried out in 4,766 animals were aseptically collected, cultivated on Lowenstein-Jensen and Stonebrink media and incubated for up to 90 days. Read More

    Changing Epidemiology of Nontuberculous Mycobacterial Lung Diseases in a Tertiary Referral Hospital in Korea between 2001 and 2015.
    J Korean Med Sci 2018 Feb 19;33(8):e65. Epub 2018 Feb 19.
    Division of Pulmonology and Critical Care Medicine, Department of Medicine, Samsung Medical Center, Sungkyunkwan University School of Medicine, Seoul, Korea.
    This study investigated the changes in the major etiologic organisms and clinical phenotypes of nontuberculous mycobacterial lung disease (NTM-LD) over a recent 15-year period in Korea. The increase of number of patients with NTM-LD was primarily due to an increase of Mycobacterium avium complex (MAC) lung disease (LD). Among MAC cases, the proportion of M. Read More

    Rare case ofpresenting as asymptomatic cavitary lung lesion.
    J Community Hosp Intern Med Perspect 2018 6;8(1):32-34. Epub 2018 Feb 6.
    Pulmonary and critical care, Interfaith Medical Center, Brooklyn, NY, USA.
    :is a rare nontuberculous mycobacterial infection. The first isolate of the species was from human sputum at University of Nebraska Medical Center. There are only a few cases have been reported and the exact behavior of the disease is not clearly described. Read More

    A High-Throughput Approach for Identification of Nontuberculous Mycobacteria in Drinking Water Reveals Relationship between Water Age and.
    MBio 2018 Feb 13;9(1). Epub 2018 Feb 13.
    Department of Civil & Environmental Engineering, University of Michigan, Ann Arbor, Michigan, USA
    Nontuberculous mycobacteria (NTM) frequently detected in drinking water (DW) include species associated with human infections, as well as species rarely linked to disease. Methods for improved the recovery of NTM DNA and high-throughput identification of NTM are needed for risk assessment of NTM infection through DW exposure. In this study, different methods of recovering bacterial DNA from DW were compared, revealing that a phenol-chloroform DNA extraction method yielded two to four times as much total DNA and eight times as much NTM DNA as two commercial DNA extraction kits. Read More

    In Vitro Efficacy of Free and Nanoparticle Formulations of Gallium(III) meso-Tetraphenylporphyrine against Mycobacterium avium and Mycobacterium abscessus and Gallium Biodistribution in Mice.
    Mol Pharm 2018 Mar 16;15(3):1215-1225. Epub 2018 Feb 16.
    Department of Pathology and Microbiology, College of Medicine , University of Nebraska Medical Center , Omaha , Nebraska 68198 , United States.
    The nontuberculous mycobacterial (NTM) pathogens, M. avium complex (MAC) and M. abscessus, can result in severe pulmonary infections. Read More

    Mycobacterium marinum: a rare cause of chronic lymphocutaneous syndrome.
    Eur J Pediatr 2018 Feb 6. Epub 2018 Feb 6.
    Sackler Faculty of Medicine, Tel Aviv University, 69978, Tel Aviv, Israel.
    We investigated the prevalence of Mycobacterium marinum lymphadenitis and describe 4 children with the disease. The database of the microbiology laboratory of a tertiary pediatric medical center was searched for all cases of nontuberculous mycobacterial lymphadenitis from 1996 to 2016. M. Read More

    Microbiologic Outcome of Interventions Against Mycobacterium avium Complex Pulmonary Disease: A Systematic Review.
    Chest 2018 Feb 2. Epub 2018 Feb 2.
    German Central Committee Against Tuberculosis, Berlin, Germany.
    Objective: Pulmonary disease (PD) caused by Mycobacterium avium complex (MAC) is increasing worldwide. We conducted a systematic review of studies that include microbiologic outcomes to evaluate current macrolide-based treatment regimens.

    Methods: We searched literature published before April 2017 by using the MEDLINE, Cochrane, and Embase databases. Read More

    Simultaneous detections of genetic fragment and single nucleotide mutation with a three-tiered output for tuberculosis diagnosis.
    Anal Chim Acta 2018 May 30;1007:1-9. Epub 2017 Dec 30.
    Department of Chemistry, Tunghai University, Taichung, 40704, Taiwan. Electronic address:
    Tuberculosis (TB) remains one of the major infectious diseases worldwide. The pathogenic bacterium, Mycobacterium tuberculosis (M.tb), continuously evolves strains carrying drug-resistance genes, thus posing a growing challenge to TB prevention and treatment. Read More

    and Nontuberculous Mycobacteria Coinfection of the Lungs.
    Turk Thorac J 2017 Jan 1;18(1):23-26. Epub 2017 Jan 1.
    Department of Pulmonary Diseases, Ataturk University School of Medicine, Erzurum, Turkey.
    Tuberculosis is highly prevalent in our country and nontuberculous mycobacteria (NTM) are frequently found in respiratory specimens recently. A 65-year-old woman was admitted with complaints of fever, cough, weight loss, and hemoptysis. On the patient's chest radiography an upper lobe cavity in both lungs and consolidation was detected. Read More

    Mycobacterium lentiflavum as the main cause of lymphadenitis in pediatric population.
    Enferm Infecc Microbiol Clin 2018 Jan 27. Epub 2018 Jan 27.
    Servicio de Microbiología y Parasitología, Hospital Universitario de la Princesa, Madrid, España.
    Introduction: Cervical lymphadenitis is the most common nontuberculous mycobacteria (NTM) infection in immunocompetent children, mainly in those under 5years. For many years Mycobacterium lentiflavum (M. lentiflavum) has been considered a rare NTM causing lymphadenitis. Read More

    Delayed onset Mycobacterium intracellulare keratitis after laser in situ keratomileusis: A case report and literature review.
    Medicine (Baltimore) 2017 Dec;96(51):e9356
    Department of Ophthalmology, Corneal Dystrophy Research Institute, Institute of Vision Research, Yonsei University College of Medicine.
    Rationale: Infectious keratitis is a relatively uncommon but potentially sight-threatening complication of laser in situ keratomileusis (LASIK). Mycobacterial keratitis is usually regarded as late onset keratitis among post-LASIK keratitis. There has been no documented case of Mycobacterium intracellulare post-LASIK keratitis of a long-latent period. Read More

    Linezolid-associated optic neuropathy in a pediatric patient with Mycobacterium nonchromogenicum: A case report.
    Medicine (Baltimore) 2017 Dec;96(50):e9200
    Laboratory of Pharmacology, National Institute of Pediatrics, and Faculty of Medicine, National Autonomous University of Mexico, Mexico City, Mexico.
    Background: Toxic optic neuropathies are alterations of the optic nerve and can be caused by environmental, pharmacological, or nutritional agents.

    Case: It is about a 7-year-old male patient, a native of the State of Mexico, Mexico who was diagnosed with cervical mycobacterial lymphadenitis that required management with linezolid.

    Observations: After 7 months of treatment, visual acuity of the left eye decreased and was accompanied by headache. Read More

    Matrix-assisted laser desorption ionization-time of flight mass spectrometry (MALDI-TOF MS) for rapid identification of.
    Med J Armed Forces India 2018 Jan 23;74(1):22-27. Epub 2017 Mar 23.
    Ex-Professor & Head, Department of Surgery, Armed Forces Medical College, Pune 411040, India.
    Background: Nontuberculous mycobacteria are increasingly being implicated in infections and have become an important cause of health care associated infections., a rapidly growing mycobacteria, is of particular concern as it tends to be resistant to commonly used therapeutic options. Conventional phenotypic methods for speciation of mycobacteria are time consuming, labor intensive and not always reliable. Read More

    Practice Guidelines for Clinical Microbiology Laboratories: Mycobacteria.
    Clin Microbiol Rev 2018 Apr 31;31(2). Epub 2018 Jan 31.
    Denver Health, Denver, Colorado, USA.
    Mycobacteria are the causative organisms for diseases such as tuberculosis (TB), leprosy, Buruli ulcer, and pulmonary nontuberculous mycobacterial disease, to name the most important ones. In 2015, globally, almost 10 million people developed TB, and almost half a million patients suffered from its multidrug-resistant form. In 2016, a total of 9,287 new TB cases were reported in the United States. Read More

    Coinfection of disseminated Talaromyces marneffei and Mycobacteria kansasii in a patient with papillary thyroid cancer: A case report.
    Medicine (Baltimore) 2017 Dec;96(52):e9072
    Department of Respiratory Medicine.
    Rationale: Recently, Talaromyces marneffei (T. marneffei) has been reported in human immunodeficiency virus (HIV)-negative patient with underlying diseases, such as oral cancer, colon cancer, haematological malignancies, connective tissue disease, diabetes mellitus, and corticosteroids or immunosuppressive agents. Similar to HIV-positive ones, such patients were observed with CD4 lymphocytopenia. Read More

    Cystic fibrosis respiratory tract salt concentration: An Exploratory Cohort Study.
    Medicine (Baltimore) 2017 Nov;96(47):e8423
    Aix-Marseille Université, URMITE Méditerranée Infection.
    In cystic fibrosis patients, electrolytic and osmolality imbalance secondary to cystic fibrosis transmembrane conductance regulator mutations may impact on mucoid secretion accumulation and secondary colonization by opportunistic pathogens such as nontuberculous mycobacteria.We performed a noninvasive exploratory prospective controlled clinical study comparing sputum salinity and acid-base characteristics of cystic fibrosis and noncystic fibrosis control patients. A total of 57 patients and 62 controls were included. Read More

    Activities of Dual Combinations of Antibiotics Against Multidrug-Resistant Nontuberculous Mycobacteria Recovered from Patients with Cystic Fibrosis.
    Microb Drug Resist 2018 Jan 25. Epub 2018 Jan 25.
    1 Department of Pathology, The Johns Hopkins School of Medicine , Baltimore, Maryland.
    Patients with cystic fibrosis (CF) are at risk for recurrent pulmonary infections due to increased viscosity of airway secretions, leading to persistent colonization with pathogenic bacteria, including nontuberculous mycobacteria (NTM). Extensive antibiotic use for treatment of infections has led to increasing antimicrobial resistance, which is a significant barrier to the treatment of NTMs. We examined the in vitro activity of several antibiotics against a selection of the most drug-resistant clinical isolates of Mycobacterium abscessus, Mycobacterium chelonae, and Mycobacterium avium complex recovered from CF patients at our institution, as well as paired combinations of antibiotics against a subset of M. Read More

    Evaluation of two protein extraction protocols based on freezing and mechanical disruption for identifying nontuberculous mycobacteria by MALDI-TOF mass spectrometry from liquid and solid cultures.
    J Clin Microbiol 2018 Jan 24. Epub 2018 Jan 24.
    Department of Microbiology, Hospital Universitari de Bellvitge-IDIBELL, Hospitalet de Llobregat, Spain
    Matrix-assisted laser desorption/ionization time-of-flight mass spectrometry (MALDI-TOF MS) has proved to be a useful diagnostic method for identifying conventional bacteria. In the case of mycobacteria, a good protein extraction protocol is essential in order to obtain reliable identification results. To date, no such protocol has been definitively established. Read More

    [The Prevalence of Nontuberculous Mycobacterial Lung Disease with orwithout Reflux Esophagitis].
    Korean J Gastroenterol 2018 Jan;71(1):18-23
    Department of Internal Medicine, Seoul National University Bundang Hospital, Seoul National University College of Medicine, Seongnam, Korea.
    Background/aims: Gastrointestinal reflux disease (GERD) is defined as 'a condition that develops when the reflux of stomach contents causes troublesome symptoms and/or complications'. It is associated with various lung diseases, including bronchial asthma, chronic bronchitis, and bronchiectasis. GERD may also affect nontuberculous mycobacterial (NTM) lung disease. Read More

    The association between erythromycin monotherapy for Mycobacterium avium complex lung disease and cross-resistance to clarithromycin: A retrospective case-series study.
    J Infect Chemother 2018 Jan 17. Epub 2018 Jan 17.
    Department of Respiratory Medicine, National Hospital Organization, National Toneyama Hospital, Japan.
    Long-term, low-dose erythromycin monotherapy, based on the anti-inflammatory effects of macrolides, has been reported to have the potential to suppress the exacerbation of Mycobacterium avium complex (MAC) lung disease with less toxicity. It remains unclear whether erythromycin monotherapy induces cross-resistance to clarithromycin, a key drug for MAC. To clarify this point, we conducted a retrospective, single-center, case-series study on patients with MAC lung disease who underwent erythromycin monotherapy for at least 6 months. Read More

    Mycobacterium xenopi Genotype Associated with Clinical Phenotype in Lung Disease.
    Lung 2018 Apr 18;196(2):213-217. Epub 2018 Jan 18.
    Department of Laboratory Medicine and Pathobiology, University of Toronto, Toronto, ON, Canada.
    Mycobacterium xenopi is responsible for pulmonary disease (PD) in Europe and Canada. Despite its high prevalence and increasing clinical importance, little is known about the genetic diversity of M. xenopi. Read More

    Genomic insights intohuman colonization.
    Stand Genomic Sci 2018 8;13. Epub 2018 Jan 8.
    Evolution of Metabolic Diversity Laboratory, Unidad de Genómica Avanzada (Langebio), Cinvestav-IPN, Irapuato, Mexico.
    (Karassova V, Weissfeiler J, Kraszanay E, Acta Microbiol Acad Sci Hung 12:275-82, 1965) is a slow-growing nontuberculousspecies found in environmental niches, and recently evidenced as an opportunistic Human pathogen. We report here the genome of a clinical isolate of(MsiGto) obtained from a patient in Guanajuato, Mexico. With a size of 6,684,413 bp, the genomic sequence of strain MsiGto is the largest of the threegenomes reported to date. Read More

    Treatment outcomes of macrolide-susceptible Mycobacterium abscessus lung disease.
    Diagn Microbiol Infect Dis 2018 Apr 16;90(4):293-295. Epub 2017 Dec 16.
    Division of Pulmonary and Critical Care Medicine, Department of Medicine, Samsung Medical Center, Sungkyunkwan University School of Medicine, Seoul, South Korea. Electronic address:
    Mycobacterium abscessus lung disease is difficult to treat due to inducible resistance to macrolides. However, 15%-20% of isolates are macrolide susceptible. In 14 patients with macrolide-susceptible M. Read More

    First Time Isolation ofFrom a Respiratory Sample.
    Clin Med Insights Circ Respir Pulm Med 2018 3;12:1179548417747529. Epub 2018 Jan 3.
    Institute of Medical Microbiology, Jena University Hospital, Jena, Germany.
    We describe the first isolation of, a rapid-growing, partial acid-resistant mycobacterium, in a respiratory specimen from a patient with exacerbated chronic obstructive pulmonary disease. To provide therapeutic recommendation for future cases, antibiotic susceptibility testing of 3 clinical isolates was performed by broth microdilution. All strains tested showed susceptibility to clarithromycin, imipenem, ciprofloxacin, and doxycycline. Read More

    Antigen 85B peptidomic analysis allows species-specific mycobacterial identification.
    Clin Proteomics 2018 8;15. Epub 2018 Jan 8.
    Virginia G. Piper Biodesign Center for Personalized Diagnostics, Arizona State University Biodesign Institute, Tempe, AZ 85287 USA.
    Background: Nontuberculous mycobacteria (NTM)-mediated infections are a growing cause of worldwide morbidity, but lack of rapid diagnostics for specific NTM species can delay the initiation of appropriate treatment regimens. We thus examined whether mass spectrometry analysis of an abundantly secreted mycobacterial antigen could identify specific NTM species.

    Methods: We analyzed predicted tryptic peptides of the major mycobacterial antigen Ag85B for their capacity to distinguishand three NTM species responsible for the majority of pulmonary infections caused by slow-growing mycobacterial species. Read More

    Characterization of non-tuberculous mycobacterium from humans and water in an Agropastoral area in Zambia.
    BMC Infect Dis 2018 01 8;18(1):20. Epub 2018 Jan 8.
    Health Promotions Unit, Institute of Economic and Social Research, University of Zambia, P.O. Box 30900, Lusaka, Zambia.
    Background: The non-tuberculous mycobacteria include those mycobacterium species that are not members of the Mycobacterium tuberculosis complex, the causative agent of pulmonary tuberculosis and Mycobacterium leprae. In Zambia, Non-tuberculous Mycobacteria are gaining recognition as pathogens of public health significance. However, there is scanty information on the isolation and speciation of these organisms for better patient management, consequently reducing the burden of these infections. Read More

    Nontuberculous Mycobacterial Infections After Silicone Breast Implant Reconstruction Emphasize a Diversity of Infecting Mycobacteria.
    Open Forum Infect Dis 2017 2;4(4):ofx189. Epub 2017 Sep 2.
    Infectious Disease Service, Department of Medicine, Memorial Sloan Kettering Cancer Center, New York, New York.
    Postsurgical skin and soft tissue infections (SSTIs) caused by nontuberculous mycobacteria (NTM) are uncommon, indolent, difficult to treat, and often mimic pyogenic bacterial infections. Here we present 3 cases of NTM infections following placement of silicone implants for reconstructive breast surgery. These cases emphasize the importance of a high index of suspicion for NTM in patients with SSI after a prosthetic reconstruction refractory to conventional antibiotic therapy and the importance of early investigation with mycobacterial-specific diagnostics. Read More

    Natural history of Mycobacterium fortuitum pulmonary infection presenting with migratory infiltrates: a case report with microbiological analysis.
    BMC Infect Dis 2018 01 2;18(1). Epub 2018 Jan 2.
    Center for Infectious Diseases and Infection Control, Keio University School of Medicine, 35 Shinanomachi, Shinjuku, Tokyo, 160-8582, Japan.
    Background: Presence of Mycobacterium fortuitum in respiratory tracts usually indicates mere colonization or transient infection, whereas true pulmonary infection occurs in patients with gastroesophageal disease. However, little is known about the diagnostic indications for true M. fortuitum pulmonary infection and the natural history of the disease. Read More

    1 OF 240