12,328 results match your criteria Mycobacterium Gordonae


Tuberculosis caused by Mycobacterium bovis infection in a captive-bred American bullfrog (Lithobates catesbeiana).

BMC Vet Res 2018 Sep 21;14(1):289. Epub 2018 Sep 21.

Universidade de São Paulo, Faculdade de Medicina Veterinária e Zootecnia, Avenida Prof. Dr. Orlando marques de Paiva 87, São Paulo, SP, 05508-270, Brazil.

Background: Tuberculosis is widely known as a progressive disease that affects endothermic animals, leading to death and/or economical losses, while mycobacterial infections in amphibians are commonly due to nontuberculous mycobacteria. To the authors' knowledge, this report describes the first case of bovine tuberculosis in a poikilothermic animal.

Case Presentation: An adult female captive American bullfrog (Lithobates catesbeianus Shaw, 1802) died in a Brazilian aquarium. Read More

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September 2018

Drug susceptibility patterns of Mycobacterium abscessus and Mycobacterium massiliense isolated from respiratory specimens.

Diagn Microbiol Infect Dis 2018 Aug 29. Epub 2018 Aug 29.

Department of Laboratory Medicine and Genetics, Samsung Medical Center, Sungkyunkwan University School of Medicine, Seoul, South Korea. Electronic address:

In this study, we aimed to retrospectively investigate and compare the drug susceptibility patterns of two major Mycobacterium abscessus complex (MABC) species; M. abscessus and M. massiliense. Read More

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A definition of the Mycobacterium avium complex for taxonomical and clinical purposes, a review.

Int J Syst Evol Microbiol 2018 Sep 19. Epub 2018 Sep 19.

4​Mycobacteria/Nocardia Laboratory, University of Texas Health Science Center at Tyler, Tyler, Texas, USA.

Nontuberculous mycobacteria, particularly the Mycobacterium avium complex (MAC) bacteria, are increasingly recognized as opportunistic pathogens of humans. As a result, studies on antibiotic treatment and taxonomy of the MAC are intensifying, but an updated definition of what constitutes the MAC, either for taxonomical studies or for clinical purposes, is lacking. On the basis of literature review and phylogenetic analyses, we propose to define the MAC as a grouping of slow-growing mycobacteria that show corresponding values in at least two of the following targets against either M. Read More

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September 2018

Drug susceptibility testing of slowly growing non-tuberculous mycobacteria using slomyco test-system.

PLoS One 2018 17;13(9):e0203108. Epub 2018 Sep 17.

Department of problems of laboratory diagnostics of tuberculosis and pathomorphology, Scientific and Clinical Antituberculosis Center of Moscow Government Health Department, Moscow, Russian Federation.

Objective: The objective of the research was to assess the susceptibility of the slowly growing nontuberculous mycobacteria strains to the antimicrobial drugs used for mycobaterioses treatment using SLOMYCO test system.

Materials And Methods: We assessed 363 NTM strains: 177 MAC (161 M. avium, 16 M. Read More

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September 2018

[Interferon gamma release assay tests and nontuberculous mycobacteria].

Rev Mal Respir 2018 Sep 13. Epub 2018 Sep 13.

Service de pneumologie et réanimation, CHU Amiens Picardie, université Picardie Jules-Verne, EA 4294, 80054 Amiens cedex 1, France.

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September 2018

Amikacin Liposome Inhalation Suspension for Treatment-Refractory Lung Disease Caused by Mycobacterium avium Complex (CONVERT): A Prospective, Open-Label, Randomized Study.

Am J Respir Crit Care Med 2018 Sep 14. Epub 2018 Sep 14.

Oregon Health & Sciences University, Infectious Diseases, Public Health and Preventive Medicine, Portland, Oregon, United States.

Rationale Improved therapeutic options are needed for patients with treatment-refractory nontuberculous mycobacterial lung disease caused by Mycobacterium avium complex (MAC). Objectives To evaluate the efficacy and safety of daily amikacin liposome inhalation suspension (ALIS) added to standard guideline-based therapy (GBT) in patients with refractory MAC lung disease. Methods Adults with amikacin-susceptible MAC lung disease and MAC-positive sputum cultures despite ≥6 months of stable GBT were randomly assigned (2:1) to receive ALIS with GBT (ALIS+GBT) or GBT alone. Read More

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September 2018
1 Read
13.00 Impact Factor

Global Environmental Nontuberculous Mycobacteria and Their Contemporaneous Man-Made and Natural Niches.

Front Microbiol 2018 30;9:2029. Epub 2018 Aug 30.

Medicine and Academic Affairs, National Jewish Health, Denver, CO, United States.

Seminal microbiological work of environmental nontuberculous mycobacteria (NTM) includes the discovery that NTM inhabit water distribution systems and soil, and that the species of NTM found are geographically diverse. It is likely that patients acquire their infections from repeated exposures to their environments, based on the well-accepted paradigm that water and soil bioaerosols - enriched for NTM - can be inhaled into the lungs. Support comes from reports demonstrating NTM isolated from the lungs of patients are genetically identical to NTM found in their environment. Read More

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August 2018
3 Reads

Double lung transplantation in an HIV-positive patient with M. kansasii infection.

Transpl Infect Dis 2018 Sep 11:e12999. Epub 2018 Sep 11.

Département de Microbiologie médicale et Infectiologie, Centre Hospitalier de l'Université de Montréal, Montréal, Québec, Canada.

Good outcomes with kidney and liver transplantation in HIV-positive patients has led clinicians to recommend lung transplantation in HIV-positive patients based on extrapolated data. Pre-transplant mycobacterial infection is associated with an increased risk of developing new infection or aggravating existing infection, though it does not contraindicate transplantation in non-HIV-infected patients. However, no data exists regarding the outcome of HIV-positive patients with pre-transplant mycobacterial infection. Read More

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September 2018
1 Read

Interaction of South Asian spices with conventional antibiotics: Implications for antimicrobial resistance for and cystic fibrosis.

Int J Mycobacteriol 2018 Jul-Sep;7(3):257-260

Department of Bacteriology, Northern Ireland Public Health Laboratory, Belfast City Hospital, Belfast; School of Biomedical Sciences, Ulster University, Coleraine; Centre for Experimental Medicine, Queen's University, Belfast, Northern Ireland, United Kingdom.

Background: Antimicrobial resistance (AMR) has rendered certain species of Mycobacterium difficult to treat clinically, particularly, the nontuberculous Mycobacterium, Mycobacterium abscessus. This bacterium is emerging in specific disease populations, including amongst cystic fibrosis (CF) patients, where AMR represent a true treatment dilemma. Therefore, any innovation with traditional antimicrobial compounds in spices, which increases the potency of existing conventional antibiotics should be investigated. Read More

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September 2018
1 Read

Bronchiectasis and Recurrent Respiratory Infections with a Gain-of-Function Variant: First Case in Korea.

Yonsei Med J 2018 Oct;59(8):1004-1007

Division of Pulmonary and Critical Care Medicine, Department of Medicine, Samsung Medical Center, Sungkyunkwan University School of Medicine, Seoul, Korea.

Bronchiectasis is a chronic disease characterized by airway infection and inflammation, leading to permanent dilation of the bronchi. Evaluation of underlying etiology is important in managing young bronchiectasis patients with recurrent infections caused by unusual pathogens. The signal transducer and activator of transcription 1 (STAT1) protein plays a key role in STAT signaling and immune system regulation. Read More

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October 2018

Disseminated Infection Secondary to an Infected Vascular Stent: Case Report and Review of the Literature.

Open Forum Infect Dis 2018 Sep 23;5(9):ofy207. Epub 2018 Aug 23.

Division of Infectious Diseases, Rutgers New Jersey Medical School, Newark.

is a rapidly growing, multidrug-resistant mycobacteria, commonly associated with pulmonary, skin, and soft tissue infections. We describe a rare case of endovascular stent infection; only 3 cases of graft infections have previously been reported. Read More

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September 2018

Mycobacterium abscessus infection following penetrations through wetsuits.

Australas J Dermatol 2018 Sep 2. Epub 2018 Sep 2.

Northern Clinical School, University of Sydney, Sydney, New South Wales, Australia.

Mycobacterium abscessus is a rapidly growing mycobacterium which is reportedly increasing in prevalence. Infection of the skin and soft tissue with M. abscessus is rare but typically associated with trauma. Read More

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September 2018

A cancer-mimicking diagnosis of peritoneal carcinosis: report of a case of abdominal non-tuberculous mycobacterial infection.

Ecancermedicalscience 2018 21;12:860. Epub 2018 Aug 21.

Department of Radiology, IEO, European Institute of Oncology IRCCS, Via Ripamonti 435, Milan 20141, Italy.

Abdominal non-tuberculous mycobacterial infection is a rare condition in healthy patients. When it occurs, it leads to the appearance of typical findings of peritoneal involvement, such as thickening of the peritoneal leaflets and the omentum, ascites and enlargement of lymph nodes and of mesenteric nodules. These findings may be misdiagnosed as tumour peritoneal implants. Read More

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Efficacy and safety of intermittent maintenance therapy after successful treatment of Mycobacterium avium complex lung disease.

J Infect Chemother 2018 Aug 29. Epub 2018 Aug 29.

Center for Infectious Diseases and Infection Control, Keio University School of Medicine, Japan. Electronic address:

Background: The optimal duration of antimicrobial therapy for Mycobacterium avium complex lung disease (MAC-LD) is unknown, and recurrence rates are high after treatment discontinuation. Intermittent therapy is recommended for the initial treatment of non-cavitary nodular/bronchiectatic MAC-LD. We hypothesized that intermittent maintenance therapy (IMT) could effectively prevent recurrence after successful treatment of MAC-LD. Read More

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Discovery of benzothiazole amides as potent antimycobacterial agents.

Bioorg Med Chem Lett 2018 Aug 25. Epub 2018 Aug 25.

Crestone, Inc, 6075 Longbow Dr. Suite 130, Boulder, CO 80301, USA. Electronic address:

From a high throughput screening of commercially available libraries against nontuberculous mycobacteria and Mycobacterium tuberculosis, numerous hits were identified with moderate activity. Extensive medicinal chemistry optimization has led to a series of potent benzothiazole amide antimycobacterial agents. Replacement of the adamantyl group with cyclohexyl derivatives and further development of this series resulted in an advanced lead compound, CRS400393, which demonstrated excellent potency and a mycobacteria-specific spectrum of activity. Read More

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August 2018
2 Reads

Adjuvant lung resection in the management of nontuberculous mycobacterial lung infection: A retrospective matched cohort study.

Respir Med 2018 09 9;142:1-6. Epub 2018 Jul 9.

Division of Respirology, Department of Medicine, University Health Network, Toronto Western Hospital, 399 Bathurst Street, Toronto, ON, M5T 2S8, Canada; Department of Medicine, University of Toronto, 27 King's College Circle, Toronto, ON, M5S 1A1, Canada. Electronic address:

Background And Objectives: Lung resection in patients with nontuberculous mycobacterial pulmonary disease (NTM-PD) is considered when medical therapy alone fails to provide long term control. Data regarding comparative and long-term outcomes are limited. We aimed to review indications and outcomes of adjuvant lung resection for NTM-PD compared with controls. Read More

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September 2018

Latent class analysis to define radiological subgroups in pulmonary nontuberculous mycobacterial disease.

BMC Pulm Med 2018 Aug 31;18(1):145. Epub 2018 Aug 31.

National Heart and Lung Institute, Imperial College London, London, UK.

Background: Nontuberculous mycobacterial (NTM) pulmonary disease has conventionally been classified on the basis of radiology into fibrocavitary and nodular-bronchiectatic disease. Whilst being of great clinical utility, this may not capture the full spectrum of radiological appearances present. The aim of this study was to use latent class analysis (LCA) as an unbiased method of grouping subjects with NTM-pulmonary disease based on their CT features and to compare the clinical characteristics of these groups. Read More

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August 2018
5 Reads

Cutaneous Infections Due to Nontuberculosis Mycobacterium: Recognition and Management.

Am J Clin Dermatol 2018 Aug 30. Epub 2018 Aug 30.

Department of Dermatology, University of Iowa Carver College of Medicine, Iowa City, IA, USA.

Nontuberculous mycobacteria (NTM) are a diverse group of organisms that are ubiquitous in the environment, and the incidence of cutaneous infections due to NTM has been steadily increasing. Cutaneous infections due to NTM can be difficult to diagnose, due to their wide spectrum of clinical presentations and histopathological findings that are often nonspecific. A variety of modalities including tissue culture and polymerase chain reaction (PCR) assays may be necessary to identify the organism. Read More

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August 2018
4 Reads

Six species of nontuberculous mycobacteria carry non-identical 16S rRNA gene copies.

J Microbiol Methods 2018 Aug 27. Epub 2018 Aug 27.

Department of Mycobacterium Reference and Research, The Research Institute of Tuberculosis, 3-1-24 Matsuyama, Kiyose, Tokyo 204-0022, Japan; Department of Basic Mycobacteriology, Graduate School of Biomedical Science, Nagasaki University, 1-12-4 Sakamoto, Nagasaki 852-8523, Japan. Electronic address:

Nontuberculous mycobacteria (NTM) can carry two or more 16S rRNA gene copies that are, in some instances, non-identical. In this study, we used a combined cloning and sequencing approach to analyze 16S rRNA gene sequences of six NTM species, Mycobacterium cosmeticum, M. pallens, M. Read More

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August 2018
1 Read
2.03 Impact Factor

Naked eye detection of the Mycobacterium tuberculosis complex by recombinase polymerase amplification-SYBR green I assays.

J Clin Lab Anal 2018 Aug 20:e22655. Epub 2018 Aug 20.

Research Group of Innovative Diagnosis of Antimicrobial Resistance, Department of Transfusion Medicine and Clinical Microbiology, Faculty of Allied Health Sciences, Chulalongkorn University, Bangkok, Thailand.

Background: Rapid diagnosis of Mycobacterium tuberculosis (Mtb) is key to controlling the spread of tuberculosis, which is a global health concern. In this study, isothermal recombinase polymerase amplification (RPA) was developed to detect specific targets of Mtb, IS6110 and IS1081. Additionally, SYBR Green I was used for endpoint detection of the RPA products by the naked eye. Read More

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August 2018
5 Reads

Epidemiology of and risk factors for extrapulmonary nontuberculous mycobacterial infections in Northeast Thailand.

PeerJ 2018 16;6:e5479. Epub 2018 Aug 16.

Department of Microbiology, Faculty of Medicine, Khon Kaen University, Khon Kaen, Thailand.

Background: Nontuberculous mycobacterial (NTM) infection is increasing worldwide. Current epidemiological data and knowledge of risk factors for this disease are limited. We investigated the trends in and risk of NTM infection in Northeast Thailand during 2012-2016. Read More

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Impact of concomitant nontuberculous mycobacteria and isolates in non-cystic fibrosis bronchiectasis.

Infect Drug Resist 2018 10;11:1137-1143. Epub 2018 Aug 10.

Department of Thoracic Medicine, Chang Gung Memorial Hospital at Linkou, Taoyuan, Taiwan,

Purpose: is associated with pulmonary function decline and high disease severity in non-cystic fibrosis (CF) bronchiectasis. The prevalence of nontuberculous mycobacteria (NTM) in non-CF bronchiectasis patients has increased recently. This study investigated the impact of NTM with or without isolates in non-CF bronchiectasis patients. Read More

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August 2018
2 Reads

In Vitro Susceptibility Testing of a Novel Benzimidazole, SPR719, Against Nontuberculous Mycobacteria.

Antimicrob Agents Chemother 2018 Aug 20. Epub 2018 Aug 20.

The University of Texas Health Science Center at Tyler, Department of Microbiology, 11937 U.S. Highway 271, Tyler, Texas 75708.

Nontuberculous mycobacteria (NTM) infections are increasing globally. complex (MAC) and are the most frequently encountered NTM among clinical laboratories, and treatment options are extremely limited. In this study, the potency of a novel benzimidazole, SPR719, the microbiologically active form of the orally available prodrug SPR720, was tested against several species of NTM. Read More

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August 2018
1 Read

Evaluation of EZplex MTBC/NTM Real-Time PCR kit: diagnostic accuracy and efficacy in vaccination.

Clin Exp Vaccine Res 2018 Jul 31;7(2):111-118. Epub 2018 Jul 31.

Department of Biotechnology, The Catholic University of Korea, Bucheon, Korea.

Purpose: Tuberculosis (TB) is mainly caused by , which is a pathogenic mycobacterial species grouped under complex (MTBC) with four other pathogenic mycobacterial species. The mycobacteria not included in MTBC are known as nontuberculous mycobacteria (NTM), and cause several pulmonary diseases including pneumonia. Currently, NTM occurrences in TB-suspected respiratory specimens have increased, due to which, precise detection of MTBC and NTM is considered critical for the diagnosis and vaccination of TB. Read More

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July 2018
4 Reads

Evaluation of the performance of two real-time PCR assays for detecting Mycobacterium species.

J Clin Lab Anal 2018 Aug 13:e22645. Epub 2018 Aug 13.

Department of Laboratory Medicine, Hanyang University Guri Hospital, Hanynag University College of Medicine, Guri, Korea.

Backgrounds: Rapid discrimination between Mycobacterium tuberculosis (MTB) and nontuberculous mycobacteria (NTM) is critical for patient treatment and to avoid unnecessary expenditure on infection control. Because real-time PCR assays distinguish MTB from NTM, we evaluated the performance of two real-time PCR assays (AdvanSure and PowerChek).

Methods: This study used 143 DNA samples from respiratory specimens which were collected based on routine PCR results using Anyplex kit. Read More

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August 2018
3 Reads

Evaluation of six decontamination procedures for isolation of Mycobacterium avium complex from avian feces.

PLoS One 2018 10;13(8):e0202034. Epub 2018 Aug 10.

Department of Electrical and Computer Engineering, University of Alberta, Edmonton, Canada.

Culture is considered the gold standard for definitive diagnosis of mycobacterial infections. However, consensus about the most suitable culture procedure for isolation of nontuberculous mycobacteria is lacking. The study compared the recoveries of mycobacteria after decontamination of spiked and fresh avian feces with 4% sodium hydroxide (NaOH), 12% sulfuric acid (H2SO4), or 1% cetylperidinium chloride (CPC), with and without mixture of three antibiotics, namely vancomycin (VAN, 100 μg/ml), nalidixic acid (NAL, 100 μg/ml), and amphotericin B (AMB, 100 μg/ml). Read More

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Mycobacterium Chimaera: A Rare Presentation.

Cureus 2018 Jun 6;10(6):e2750. Epub 2018 Jun 6.

Medicine, Jersey Shore University Medical Center, Neptune City, USA.

Mycobacterium chimaera is an indolent nontuberculous mycobacterium which is abundant in soil, dust, and water. Although lacking recognition garnered by other mycobacteria (i.e. Read More

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Extrapulmonary Nontuberculous Mycobacterial Disease Surveillance - Oregon, 2014-2016.

MMWR Morb Mortal Wkly Rep 2018 Aug 10;67(31):854-857. Epub 2018 Aug 10.

Nontuberculous mycobacteria (NTM), ubiquitous in soil and water, usually infect immunocompromised persons. However, even healthy persons are susceptible to infection through percutaneous inoculation. Although 77% of NTM diseases manifest as primarily pulmonary illnesses (1), NTM also infect skin, bones, joints, the lymphatic system, and soft tissue. Read More

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August 2018
8 Reads

Ibrutinib Therapy and Skin and Soft Tissue Infection.

Open Forum Infect Dis 2018 Jul 18;5(7):ofy168. Epub 2018 Jul 18.

Infectious Diseases Section, Louis Stokes Cleveland Department of Veterans Affairs Medical Center, Cleveland, Ohio.

Ibrutinib is an irreversible inhibitor of Bruton's tyrosine kinase approved for the treatment of B-cell malignancies. There is growing concern about the risk of opportunistic infections following ibrutinib therapy. Herein, we describe the first case of skin and soft tissue infection in a patient receiving ibrutinib and recount the challenges in treating this infection. Read More

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July 2018
6 Reads

Induction of spontaneous curvature and endocytosis: Unwanted consequences of cholesterol extraction using methyl-β-Cyclodextrin.

Commun Integr Biol 2018 13;11(2):1-4. Epub 2018 Mar 13.

Keenan Research Centre for Biomedical Science, St. Michael's Hospital, Toronto, ON, Canada.

Membrane curvature is a property of biological membranes essential for organelle morphology and the formation of tubulovesicular carriers. Curvature generation is influenced by the lipid composition of the membrane and protein-mediated processes. Lipids with small headgroups, such as phosphatidic acid, are conical and impose negative curvature on a monolayer. Read More

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Aortic Root Pseudoaneurysm Caused by Mycobacterium Chimaera.

Ann Thorac Surg 2018 Aug 3. Epub 2018 Aug 3.

Department of Cardiothoracic Surgery.

Nontuberculous mycobacteria cause severe pulmonary, vascular graft and bloodstream infections following cardiac surgery. Patient prognosis remains poor due to delays in diagnosis and treatment. Complicated aortic root infections caused by nontuberculous mycobacteria have been mostly fatal. Read More

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August 2018
1 Read

Quantitative N-Terminal Footprinting of Pathogenic Mycobacteria Reveals Differential Protein Acetylation.

J Proteome Res 2018 Sep 16;17(9):3246-3258. Epub 2018 Aug 16.

N-terminal acetylation (NTA) is a post-transcriptional modification of proteins that is conserved from bacteria to humans. In bacteria, the enzymes that mediate protein NTA also promote antimicrobial resistance. In pathogenic mycobacteria, which cause human tuberculosis and other chronic infections, NTA has been linked to pathogenesis and stress response, yet the fundamental biology underlying NTA of mycobacterial proteins remains unclear. Read More

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September 2018
3 Reads

Management of Extrapulmonary Nontuberculous Mycobacterial Infections.

Semin Respir Crit Care Med 2018 Jun 2;39(3):399-410. Epub 2018 Aug 2.

Division of Mycobacterial and Respiratory Infections, National Jewish Health, Denver, Colorado.

Extrapulmonary disease occurs in a minority of nontuberculous mycobacterial (NTM) infections. The pattern of disease tends to be multifocal in immunocompromised individuals and localized in the immunocompetent. There is increasing recognition of disseminated infection, as a complication of cardiac surgery, and focal infections due to rapidly growing mycobacteria. Read More

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June 2018
1 Read

Nontuberculous Mycobacteria in Cystic Fibrosis.

Semin Respir Crit Care Med 2018 Jun 2;39(3):383-391. Epub 2018 Aug 2.

Department of Medicine, Medical University of South Carolina, Charleston, South Carolina.

Nontuberculous mycobacteria (NTM) can cause chronic pulmonary infection in susceptible hosts. Individuals with cystic fibrosis (CF), a multisystem disease predominated by progressive structural lung disease, are particularly vulnerable. Only recently have NTM been recognized for their potential to cause lung deterioration in CF patients. Read More

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Treatment of Other Nontuberculous Mycobacteria.

Semin Respir Crit Care Med 2018 Jun 2;39(3):377-382. Epub 2018 Aug 2.

Department of Respiratory Diseases, Amiens University Hospital, Amiens, France.

Nontuberculous mycobacteria (NTM) are numerous, and for the vast majority of them, randomized studies are lacking and data regarding optimal treatment are limited. When complex (MAC) and are excluded, the main NTM are , and . Treatment is long (at least 12 months after culture conversion according to recommendations by scientific societies) and difficult (at least three drugs are required, each of which have potential adverse events). Read More

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June 2018
2 Reads

Treatment of Mycobacterium abscessus Complex.

Semin Respir Crit Care Med 2018 Jun 2;39(3):362-376. Epub 2018 Aug 2.

Division of Infectious Diseases, Department of Medicine, Oregon Health and Sciences University, Portland, Oregon.

Of the nontuberculous mycobacteria (NTMs) causing lung disease, members of the complex (MABc) present a formidable obstacle to successful management. This challenge starts from a poorly understood pathogenesis, continues with complicated subspecies variation in treatment response, and extends to the multidrug-resistant nature of these organisms. The disease often necessitates the use of intravenous therapy, toxic drug combinations, and, in some cases, lung resection. Read More

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Diagnosis of Nontuberculous Mycobacteria Lung Disease.

Semin Respir Crit Care Med 2018 Jun 2;39(3):343-350. Epub 2018 Aug 2.

Consultant Respiratory Physician, Royal Brompton Hospital, London, United Kingdom.

The diagnosis of pulmonary nontuberculous mycobacteria (NTM) disease may be challenging, as their presence alone does not necessarily indicate disease and diagnosis requires the integration of clinical, radiological, and microbiological findings. The first step is to suspect NTM disease; however, clinical manifestations of NTM are nonspecific and it may not be possible to separate them from those caused by underlying respiratory disease. The radiological appearance generally falls into two patterns, fibrocavitary disease and nodular-bronchiectatic disease; consolidation, infiltrates, and solitary nodules are also described. Read More

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Geographic Distribution of Nontuberculous Mycobacteria Isolated from Clinical Specimens: A Systematic Review.

Semin Respir Crit Care Med 2018 Jun 2;39(3):336-342. Epub 2018 Aug 2.

Department of Pulmonary Diseases, Radboud University Medical Center, Nijmegen, The Netherlands.

Isolation frequency of nontuberculous mycobacterial (NTM) differs per region. Differences in isolation frequency as well as frequencies in clinical relevance are relevant for daily clinical practice. We conducted a systematic review, searching PubMed to assess these differences. Read More

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June 2018
2.71 Impact Factor

An Aspartate-Specific Solute-Binding Protein Regulates Protein Kinase G Activity To Control Glutamate Metabolism in Mycobacteria.

MBio 2018 Jul 31;9(4). Epub 2018 Jul 31.

Leicester Tuberculosis Research Group, Department of Infection, Immunity and Inflammation, University of Leicester, Leicester, United Kingdom

Signaling by serine/threonine phosphorylation controls diverse processes in bacteria, and identification of the stimuli that activate protein kinases is an outstanding question in the field. Recently, we showed that nutrients stimulate phosphorylation of the protein kinase G substrate GarA in and and that the action of GarA in regulating central metabolism depends upon whether it is phosphorylated. Here we present an investigation into the mechanism by which nutrients activate PknG. Read More

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July 2018
4 Reads

NK Cell-Derived IFN-γ Protects against Nontuberculous Mycobacterial Lung Infection.

J Immunol 2018 Sep 30;201(5):1478-1490. Epub 2018 Jul 30.

Department of Respiratory Therapy, Fu Jen Catholic University, Xinzhuang, New Taipei City 24205, Taiwan

In developed countries, pulmonary nontuberculous mycobacteria (NTM) infections are more prevalent than infections. Given the differences in the pathogenesis of NTM and infections, separate studies are needed to investigate the pathological effects of NTM pathogens. Our previous study showed that anti-IFN-γ autoantibodies are detected in NTM-infected patients. Read More

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September 2018
1 Read

Diagnosing nontuberculous mycobacterial cervicofacial lymphadenitis in children: A systematic review.

Int J Pediatr Otorhinolaryngol 2018 Sep 19;112:48-54. Epub 2018 Jun 19.

Department of Oral and Maxillofacial Surgery, Academic Medical Center, Amsterdam, The Netherlands; Department of Head and Neck Oncology and Surgery, Netherlands Cancer Institute/Antoni Van Leeuwenhoek Hospital, Amsterdam, The Netherlands.

Objectives: Widespread controversy exists regarding correct diagnosing nontuberculous mycobacterial cervicofacial (NTM) lymphadenitis. This study intends to gather the available evidence with respect to diagnosing NTM cervicofacial lymphadenitis.

Methods: A review protocol was developed based on the Preferred Reporting Items for Systematic Reviews and Meta-Analysis (PRISMA)-statement (www. Read More

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September 2018
4 Reads

Genotyping and clarithromycin susceptibility testing of Mycobacterium avium subsp. hominissuis isolated in Tuscany, Italy.

Infect Genet Evol 2018 Jul 25;65:144-149. Epub 2018 Jul 25.

Dipartimento di Ricerca Traslazionale e delle Nuove Tecnologie, in Medicina e Chirurgia, Università di Pisa, I-56127 Pisa, Italy. Electronic address:

Mycobacterium avium subsp. hominissuis (MAH) is a major cause of nontuberculous mycobacteria infection and the incidence of MAH infections is increasing in many countries. This study aimed at determining the VNTR-based genetic diversity and the susceptibility to clarithromycin of a collection of 71 MAH human strains isolated in the last seven years. Read More

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Sputum Detection of Predisposing Genetic Mutations in Women with Pulmonary Nontuberculous Mycobacterial Disease.

Sci Rep 2018 Jul 27;8(1):11336. Epub 2018 Jul 27.

Department of Cellular and Molecular Biology, The University of Texas Health Science Center at Tyler, Tyler, Texas, USA.

Nontuberculous mycobacterial lung disease (NTM), including Mycobacterium avium complex (MAC), is a growing health problem in North America and worldwide. Little is known about the molecular alterations occurring in the tissue microenvironment during NTM pathogenesis. Utilizing next generation sequencing, we sequenced sputum and matched lymphocyte DNA in 15 MAC patients for a panel of 19 genes known to harbor cancer susceptibility associated mutations. Read More

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July 2018
2 Reads

Characteristics of patients with bronchoscopy-diagnosed pulmonary Mycobacterium avium complex infection.

J Infect Chemother 2018 Oct 25;24(10):822-827. Epub 2018 Jul 25.

Department of Respiratory Medicine, Toho University Omori Medical Center, 6-11-1 Omori-nishi, Otaku, Tokyo, 143-8540, Japan.

Background: We occasionally treat patients with clinically suspected pulmonary Mycobacterium avium complex (MAC) infection and negative MAC culture on bronchoscopy.

Objective: This study aimed to investigate the usefulness of bronchoscopy in patients with suspected MAC lung disease with nodular bronchiectasis on chest computed tomography (CT) and to clarify the clinical characteristics of these patients.

Methods: We reviewed the records of 71 patients with clinically suspected pulmonary MAC infection on chest CT who underwent bronchoscopy. Read More

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October 2018
2 Reads

High rates of Mycobacterium fortuitum isolation in respiratory samples from Iranian patients with suspected tuberculosis: is it clinically important?

J Med Microbiol 2018 Sep 27;67(9):1243-1248. Epub 2018 Jul 27.

3​Microbiology Research Center (MRC), Pasteur Institute of Iran, Tehran, Iran.

Purpose: Although Mycobacterium fortuitum (M. fortuitum) is not an organism rarely isolated from respiratory samples, its clinical importance is still not fully understood, which therefore prompted our current study.

Methodology: We evaluated respiratory samples from 6800 patients with suspected tuberculosis from May 2014 to May 2016, for the detection of M. Read More

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September 2018

Nontuberculous mycobacteria infection risk in medical tourism.

JAAPA 2018 Aug;31(8):45-47

At the time this article was written, Antonina Avanzi, Kristin Bierbauer, and Guillermo Vales-Kennedy were students in the PA program at Pace University-Lenox Hill Hospital in New York, N.Y. Jean Covino is a clinical professor and director of didactic education in the PA program at Pace University-Lenox Hill Hospital, and practices at Medemerge Family Practice/Urgent Care Center in Green Brook, N.J. The authors have disclosed no potential conflicts of interest, financial or otherwise.

The increasing popularity of medical tourism among US citizens has led to the rising incidence of nontuberculous mycobacteria (NTM) infections from cosmetic surgery performed in other countries. Clinicians must be aware of these infections and the potential difficulties in treating them. The most common NTM species isolated from cutaneous infections in medical tourists is Mycobacterium abscessus. Read More

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August 2018
3 Reads

Radiology of Chronic Cavitary Infections.

J Thorac Imaging 2018 Sep;33(5):334-343

Pulmonary Section, Denver Veterans Affairs Medical Center.

Chronic cavitary lung disease is an uncommon manifestation of pulmonary infection, and is a pattern which worldwide is most commonly caused by reactivation tuberculosis. Other organisms, however, can cause similar radiologic patterns. Endemic fungi have long been recognized as potential causes of this pattern in North and South America, but the frequency with which these diseases present with chronic cavities in North America is relatively small. Read More

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September 2018

MmpL3 as a Target for the Treatment of Drug-Resistant Nontuberculous Mycobacterial Infections.

Front Microbiol 2018 10;9:1547. Epub 2018 Jul 10.

Mycobacteria Research Laboratories, Department of Microbiology, Immunology and Pathology, Colorado State University, Fort Collins, CO, United States.

Nontuberculous mycobacterial (NTM) pulmonary infections are emerging as a global health problem and pose a threat to susceptible individuals with structural or functional lung conditions such as cystic fibrosis, chronic obstructive pulmonary disease and bronchiectasis. complex (MAC) and complex (MABSC) species account for 70-95% of the pulmonary NTM infections worldwide. Treatment options for these pathogens are limited, involve lengthy multidrug regimens of 12-18 months with parenteral and oral drugs, and their outcome is often suboptimal. Read More

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July 2018
6 Reads
3.94 Impact Factor

Zinc depletion induces ribosome hibernation in mycobacteria.

Proc Natl Acad Sci U S A 2018 08 23;115(32):8191-8196. Epub 2018 Jul 23.

Division of Genetics, Wadsworth Center, New York State Department of Health, Albany, NY 12208;

Bacteria respond to zinc starvation by replacing ribosomal proteins that have the zinc-binding CXXC motif (C+) with their zinc-free (C-) paralogues. Consequences of this process beyond zinc homeostasis are unknown. Here, we show that the C- ribosome in is the exclusive target of a bacterial protein Y homolog, referred to as mycobacterial-specific protein Y (MPY), which binds to the decoding region of the 30S subunit, thereby inactivating the ribosome. Read More

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August 2018
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Responding to Mycobacterium chimaera heater cooler unit contamination, International and national inter-sectoral collaboration coordinated in the state of Queensland, Australia.

J Hosp Infect 2018 Jul 20. Epub 2018 Jul 20.

Medical Advisor TB and Infectious Diseases, Communicable Diseases Branch, Queensland Health, and Director Queensland Mycobacterium Reference Laboratory, Pathology, Brisbane, Queensland, Australia.

Background: The Mycobacterium chimaera patient infection post open cardiac surgery index case, in the state of Queensland, Australia, prompted a centralised coordinated response to mitigate risk.

Aim: To describe the public health response to Mycobacterium chimaera contamination of heater cooler units and patient infection.

Methods: A public health sector strategy was developed with national and international consultation to respond to the threat of Mycobacterium chimaera contaminated HCU. Read More

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July 2018
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