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    12125 results match your criteria Mycobacterium Gordonae

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    Bronchial wash culture is less valuable in patients suspected to have nontuberculous mycobacteria lung disease for bilateral bronchiectasis with nodules.
    Int J Mycobacteriol 2018 Apr-Jun;7(2):178-182
    Department of Pulmonology, Yokohama City University Graduate School of Medicine, Yokohama, Japan.
    Backgrounds: Bronchiectasis (BE) with nodules on chest computed tomography (CT) is one of the radiological findings of nontuberculous mycobacteria (NTM) lung disease. However, the NTM lung disease is not diagnosed in some patients who undergo bronchoscopy, though their radiological findings show BE with nodules. We need the indicator to distinguish the patients who would not be given the diagnosis of NTM lung disease with bronchoscopy. Read More

    Antimicrobial effect of dimethyl sulfoxide and -Dimethylformamide on : Implications for antimicrobial susceptibility testing.
    Int J Mycobacteriol 2018 Apr-Jun;7(2):134-136
    Centre for Experimental Medicine, Queen's University; Department of Bacteriology, Northern Ireland Public Health Laboratory, Belfast City Hospital, Northern Ireland, United Kingdom.
    Background: The emergence of antimicrobial resistance globally has initiated the discovery of novel antibiotics and other antimicrobial substances. Many of these novel compounds may be found in phytochemicals, where these novel compounds are extremely difficult to redissolve for antimicrobial susceptibility testing, following extraction. The aim of this study was to examine the potential antimicrobial effects of the common solvents, dimethyl sulfoxide (DMSO) and N, N-dimethylformamide (DMF), which are commonly employed as solvents of novel antimicrobial substances, with the nontuberculous Mycobacterium and Mycobacterium abscessus. Read More

    Effect of chlorine on and in planktonic and Biofilm State.
    Int J Mycobacteriol 2018 Apr-Jun;7(2):122-127
    Department of Biology, Biochemistry and Pharmacy, Southern National University, San Juan 670, Bahía Blanca, Argentina.
    Background: : There is evidence that drinking water could be a source of infections with pathogenic nontuberculous mycobacteria (NTM) potentially risky to human health. The aim was to investigate the resistance of two NTM isolated from drinking water, Mycobacterium gordonae and Mycobacterium chubuense, at different concentrations of chlorine (as sodium hypochlorite), used in drinking water sanitation.

    Methods: : The NTM were grown in suspension and in biofilms and were challenged with biocide for 10 and 60 min. Read More

    First case report of human infection with .
    JMM Case Rep 2018 May 22;5(5):e005146. Epub 2018 Mar 22.
    University of Queensland, Brisbane, Queensland, Australia.
    Introduction: We describe the first detailed case report of human infection with . Infection with non-tuberculous mycobacteria (NTM) related to is well described, despite the lack of previous confirmed reports of related human disease. Localised cervical lymphadenitis is the most common NTM disease in children, with species closely related to such as and , having been shown to be rare causative agents. Read More

    Pulmonary co-infection with nocardia species and nontuberculous mycobacteria mimicking miliary tuberculosis in a patient with Crohn's disease under combined immunosuppressive therapy.
    Z Gastroenterol 2018 06 11;56(6):569-572. Epub 2018 Jun 11.
    Jena University Hospital, Dept. Internal Medicine IV.
    Nocardiosis is a rare infection caused by ubiquitous soil-born, acid-resistant, Gram-positive bacteria that can be life-threatening in immunocompromised patients. Originally usually diagnosed in HIV-positive patients, only few cases have been reported in patients on immunosuppressive therapy for inflammatory bowel disease or rheumatologic disorders. We present a case of a 32-year-old man who was treated with infliximab, prednisolone, and azathioprine for severe terminal ileitis. Read More

    How can we improve the outcome for transplant patients with nontuberculous mycobacterial infections?
    Future Microbiol 2018 Jun 11. Epub 2018 Jun 11.
    Department of Medicine, Jackson Memorial Hospital, Miami, FL, 33136, USA.
    Nontuberculous mycobacteria (NTM) are environmental organisms that are rapidly emerging as pathogens in the transplant population. The prevalence of infection in transplant recipients remains unknown. While guidelines exist for treatment of NTM, neither the American Thoracic Society, the Infectious Diseases Society of America, nor the British Thoracic Society guidelines dictate the approach needed for transplant recipients. Read More

    Disseminated nontuberculous mycobacterial disease in a cat caused by Mycobacterium sp. strain MFM001.
    Vet Microbiol 2018 Jul 19;220:90-96. Epub 2018 May 19.
    Laboratory of Small Animal Clinics, Veterinary Teaching Hospital, Azabu University, 1-17-71, Fuchinobe, Chuo, Sagamihara, Kanagawa, 252-5201, Japan. Electronic address:
    Mycobacterium sp. strain MFM001 (MFM001), a new strain of slow-growing nontuberculous mycobacteria not associated with the Mycobacterium avium complex, led to disseminated mycobacterial disease characterized by transmural granulomatous gastroenterocolitis of lepromatous type in a cat treated with immunosuppressive medication. MFM001 was found to be closely related to M. Read More

    Development of Macrolide Resistance and Reinfection in Refractory Mycobacterium avium Complex Lung Disease.
    Am J Respir Crit Care Med 2018 Jun 7. Epub 2018 Jun 7.
    Samsung Medical Center, Sungkyunkwan University School of Medicine, Division of Pulmonary and Critical Care Medicine, Department of Medicine, Seoul, Korea, Republic of ;
    Rationale: Patients with refractory Mycobacterium avium complex lung disease (MAC-LD) undergo long-term macrolide therapy, but macrolide resistance develops infrequently.

    Objectives: The aim of this study was to determine whether reinfection was a factor in the low incidence of macrolide resistance in patients with refractory MAC-LD.

    Methods: Among 481 patients with treatment-naive MAC-LD who started antibiotic treatment between January 2002 and December 2013, we identified 72 patients with refractory disease, characterized by persistently positive sputum cultures despite ≥12 months of treatment. Read More

    Evaluation of MALDI-TOF MS for identification of nontuberculous mycobacteria isolated from clinical specimens in mycobacteria growth indicator tube medium.
    New Microbiol 2018 Jun 6;41(2). Epub 2018 Jun 6.
    Istanbul University, Istanbul Faculty of Medicine, Department of Medical Microbiology, Istanbul, Turkey.
    Nowadays, there is a rising worldwide incidence of diseases caused by nontuberculous mycobacteria (NTM) species, especially in immunocompromised patients and those with underlying chronic pulmonary diseases. Recently, matrix-assisted laser desorption ionization-time of flight mass spectrometry (MALDI-TOF MS) became a method of choice for the identification of NTM species. The aim of this study was to evaluate MALDI-TOF MS for the identification of NTM isolates compared to the PCR-restriction enzyme analysis (PRA)-hsp65 method. Read More

    Nontuberculous mycobacteria in the environment of Hranice Abyss, the world's deepest flooded cave (Hranice karst, Czech Republic).
    Environ Sci Pollut Res Int 2018 Jun 6. Epub 2018 Jun 6.
    Faculty of Regional Development and International Studies, Mendel University in Brno, tr. Generala Piky 7, 61300, Brno, Czech Republic.
    Nontuberculous mycobacteria (NTM) are widely distributed in the environment. On one hand, they are opportunistic pathogens for humans and animals, and on the other hand, they are effective in biodegradation of some persistent pollutants. Following the recently recorded large abundance of NTM in extreme geothermal environments, the aim of the study was to ascertain the occurrence of NTM in the extreme environment of the water zone of the Hranice Abyss (HA). Read More

    Scientific rationale for traditional use of plants to treat tuberculosis in the eastern region of the OR Tambo district, South Africa.
    J Ethnopharmacol 2018 Jun 2;224:250-260. Epub 2018 Jun 2.
    Phytomedicine Programme, Department of Paraclinical Sciences, University of Pretoria, Private Bag X04, Onderstepoort, 0110 Pretoria, South Africa. Electronic address:
    Ethnopharmacological Relevance: Tuberculosis (TB) remains a major health problem for humans worldwide, and was responsible for 1.4 million human deaths in 2015 alone. Although there is treatment for TB, emerging multi-drug, extensively drug and totally drug resistant forms of this disease, as well as co-infection with human immunodefiency virus (HIV) continue to worsen the situation. Read More

    Elevated IgM levels as a marker for a unique phenotype in patients with Ataxia telangiectasia.
    BMC Pediatr 2018 Jun 4;18(1):185. Epub 2018 Jun 4.
    The Claudio Cohen Department of Pediatric Intensive Care, The Edmond and Lily Safra Children's Hospital, Tel- Hashomer, Israel.
    Background: Ataxia telangiectasia (AT) is a rare, multi-systemic, genetic disorder. Mutations in the ATM gene cause dysfunction in cell-cycle, apoptosis and V (D) J recombination leading to neurodegeneration, cellular, humoral immunodeficiencies and predisposition to malignancies. Previous studies have suggested that a sub-group of AT patients with elevated IgM levels have a distinct and more severe phenotype. Read More

    Cutaneous Mycobacterium chelonae infection following autologous peripheral blood stem cell transplantation for POEMS syndrome.
    J Infect Chemother 2018 May 31. Epub 2018 May 31.
    Department of Hematology, Tottori Prefectural Central Hospital, Tottori, Japan.
    Although hematopoietic stem cell transplantation (HSCT) may increase the curability of refractory hematologic diseases, it requires complication management due to a long-term immunocompromised state. We experienced a case who received an autologous peripheral blood stem cell transplantation (Auto-PBSCT) for POEMS syndrome (polyneuropathy, organomegaly, endocrinopathy, monoclonal gammopathy, and skin changes) and developed cutaneous Mycobacterium chelonae infection. It is clear that attention needs to be paid to prevent bacterial, fungal and viral infection after HSCT. Read More

    Clinical, radiological and molecular features of Mycobacterium kansasii pulmonary disease.
    Respir Med 2018 Jun 9;139:91-100. Epub 2018 May 9.
    Department of Applied Microbiology, Institute of Microbiology, Faculty of Biology, University of Warsaw, Warsaw, Poland. Electronic address:
    Background: Studies concerning sociodemographic, clinical, and laboratory features of Mycobacterium kansasii pulmonary disease are few and based on small patient cohorts. The objective of the study was to evaluate characteristics of patients from whom M. kansasii respiratory isolates were recovered and to provide a detailed description of M. Read More

    Prevalence and clinical outcomes of nontuberculous mycobacteria in a Brazilian cystic fibrosis reference center.
    Pathog Dis 2018 May 28. Epub 2018 May 28.
    Universidade Estadual de Campinas, School of Medical Sciences, Center for Investigation in Pediatrics (CIPED).
    Nontuberculous mycobacteria (NTM) have been well established as an opportunistic pathogenic bacterial group for cystic fibrosis (CF) patients, with a prevalence ranging from 3 to 23% worldwide. A myriad of factors can bias the prevalence rate in different CF centers, especially misdiagnosis as systematic screening for NTM are still lacking in a number of centers. Here, we evaluated the presence and clinical outcomes of NTM isolation in microbiological respiratory cultures from CF patients attending a Brazilian reference center after setting up a systematic diagnostic protocol. Read More

    The first Saudi Arabian national inventory study revealed the upcoming challenges of highly diverse non-tuberculous mycobacterial diseases.
    PLoS Negl Trop Dis 2018 05 25;12(5):e0006515. Epub 2018 May 25.
    Department of Infection and Immunity, King Faisal Specialist Hospital and Research Centre, Riyadh, Saudi Arabia.
    Background: Incidences of nontuberculous mycobacteria (NTM) causing pulmonary and extrapulmonary diseases are reportedly increasing globally and the current epidemiologic situation in Saudi Arabia remains unclear. To study such trend, we carried out a nationwide systematic epidemiological study focusing on NTM diseases for the first time in the country.

    Methods/principle Findings: A nationwide collection of NTM isolates with clinical and demographical data was conducted for a period of 24 months. Read More

    Draft Genome Sequence of Mycobacterium montefiorense Isolated from Japanese Black Salamander (Hynobius nigrescens).
    Genome Announc 2018 May 24;6(21). Epub 2018 May 24.
    Department of Mycobacteriology, Leprosy Research Center, National Institute of Infectious Diseases, Tokyo, Japan
    is a member of the complex, the largest group of nontuberculous mycobacteria. Here, we report the genome sequence of isolate BS, isolated from diseased Japanese black salamander () reared in an aquarium in Japan. This is the first reported case of an infection in an amphibian. Read More

    Clinical aspects in patients with pulmonary infection caused by mycobacteria of the Mycobacterium abscessus complex, in the Brazilian Amazon.
    J Bras Pneumol 2018 Apr;44(2):93-98
    Programa de Pós-Graduação, Pontifícia Universidade Católica do Rio de Janeiro, Rio de Janeiro, RJ, Brazil.
    Objective: To describe the clinical manifestations of patients with pulmonary infection caused by mycobacteria of the Mycobacterium abscessus complex (MABSC), and to compare these manifestations with those of patients infected with other nontuberculous mycobacteria (NTM).

    Methods: This was a retrospective cohort study involving 43 patients divided into two groups: the MABSC group, consisting of patients with pulmonary infection caused by MABSC (n = 17); and the NTM group, consisting of patients with pulmonary infection caused by NTM other than MABSC (n = 26). Patients were previously treated with a regimen of rifampin, isoniazid, pyrazinamide, and ethambutol before the diagnosis of NTM was confirmed by two culture-positive sputum samples. Read More

    Nontuberculous mycobacterial lung disease in a high tuberculosis incidence setting in Brazil.
    J Bras Pneumol 2018 Apr;44(2):106-111
    Hospital Sanatório Partenon, Porto Alegre, RS, Brasil.
    Objective: The incidence of lung disease caused by nontuberculous mycobacteria (NTM) has been increasing worldwide. In Brazil, there are few studies about nontuberculous mycobacterial lung disease (NTMLD), and its prevalence is yet to be known. Our objective was to determine the specific etiology of the disease in the state of Rio Grande do Sul, Brazil, as well as the frequency and diversity of NTM species in our sample of patients. Read More

    Profiling non-tuberculous mycobacteria in an Asian setting: characteristics and clinical outcomes of hospitalized patients in Singapore.
    BMC Pulm Med 2018 May 22;18(1):85. Epub 2018 May 22.
    Department of Respiratory and Critical Care Medicine, Tan Tock Seng Hospital, 11 Jalan Tan Tock Seng, Singapore, 308433, Singapore.
    Background: Non-tuberculous mycobacteria (NTM) infection is an increasing problem worldwide. The epidemiology of NTM in most Asian countries is unknown. This study investigated the epidemiology, and clinical profile of inpatients in whom NTM was isolated from various anatomical sites in a Singaporean population attending a major tertiary referral centre. Read More

    NonTuberculous Mycobacteria infection and lung transplantation in cystic fibrosis: a worldwide survey of clinical practice.
    BMC Pulm Med 2018 May 22;18(1):86. Epub 2018 May 22.
    Institute of Cellular Medicine, Newcastle University, Medical School, Framlington Place, Newcastle upon Tyne, NE2 4HH, UK.
    Background: In people with cystic fibrosis infection with NonTuberculous Mycobacteria is of increasing prevalence. Mycobacterium abscessus complex is of particular concern and has been associated with adverse clinical outcomes. Optimal treatment usually requires multiple antibiotics for over 12 months. Read More

    Pulmonary Infections with Nontuberculous Mycobacteria, Catalonia, Spain, 1994-2014.
    Emerg Infect Dis 2018 Jun;24(6):1091-1094
    In Spain, systematic reporting of pulmonary infections with nontuberculous mycobacteria is not mandatory. Therefore, to determine trends, we retrospectively identified cases for January 1994-December 2014 in Catalonia. Over the 21 years, prevalence increased and was associated with being male. Read More

    Nontuberculous mycobacterial and Aspergillus infections among cadaveric lung transplant recipients in Japan.
    Respir Investig 2018 May 4;56(3):243-248. Epub 2018 Feb 4.
    Department of Respiratory Medicine, National Hospital Organization, Kinki-Chuo Chest Medical Center, 1180 Nagasone-Cho, Kita-Ku, Sakai City, Osaka 591-8555, Japan. Electronic address:
    Background: Lung transplantation is an effective treatment modality for respiratory failure. Chronic lung infections, including infections caused by nontuberculous mycobacteria (NTM) and Aspergillus, are difficult to control, and uncontrolled infections are relative contraindications for lung transplantation. However, few reports have documented the incidence and outcome of these infections in lung transplant recipients. Read More

    [Non-tuberculous mycobacterial cervical adenitis in children: 2 cases].
    Ann Dermatol Venereol 2018 May 14. Epub 2018 May 14.
    Service de dermatologie, CHU d'Angers, 4, rue Larrey, 49100 Angers, France.
    Background: Cervical lymphadenitis is the most common manifestation of infection with nontuberculous mycobacteria (NTM) in immunocompetent children. Nevertheless, it is poorly known by dermatologists. Its incidence, which is currently increasing since the cessation of BCG vaccination in 2007, raises several issues regarding its pathophysiology, diagnosis and management. Read More

    Preliminary Study on Drug Susceptibility Profile and Resistance Mechanisms to Macrolides of Clinical Isolates of Non-tuberculous Mycobacteria from China.
    Biomed Environ Sci 2018 Apr;31(4):290-299
    State Key Laboratory for Infectious Diseases Prevention and Control, Collaborative Innovation Center for Diagnosis and Treatment of Infectious Diseases, National Institute for Communicable Disease Control and Prevention, Chinese Center for Disease Control and Prevention, Beijing 102206, China.
    Objective: Macrolide susceptibility and drug resistance mechanisms of clinical non-tuberculous mycobacteria (NTM) isolates were preliminarily investigated for more accurate diagnosis and treatment of the infection in China.

    Methods: Four macrolides, including clarithromycin (CLAR), azithromycin (AZM), roxithromycin (ROX), and erythromycin (ERY), were used to test the drug susceptibility of 310 clinical NTM isolates from six provinces of China with the broth microdilution method. Two resistance mechanisms, 23S rRNA and erm, were analyzed with nucleotide sequence analysis. Read More

    Cutaneous Nontuberculous Mycobacterial Infections in Alberta, Canada: An Epidemiologic Study and Review.
    J Cutan Med Surg 2018 May 1:1203475418776945. Epub 2018 May 1.
    3 Division of Diagnostic and Applied Microbiology, Department of Laboratory Medicine and Pathology, University of Alberta and the Alberta Provincial Public Health Laboratory, WC Mackenzie Health Sciences Centre, Edmonton, AB, Canada.
    Background: Cutaneous infections caused by nontuberculous mycobacteria (NTM) occur infrequently. Nonetheless, the incidence of NTM infections is reported to be increasing. In Canada, cutaneous NTM infections have not been well described. Read More

    : clinical, radiological and microbiological characteristics in 97 patients.
    Antimicrob Agents Chemother 2018 May 14. Epub 2018 May 14.
    Sorbonne Universités, UPMC Univ Paris 06, Inserm, Centre d'Immunologie et des Maladies Infectieuses (Cimi-Paris), UMR 1135, 91 Boulevard de l'Hôpital, F-75013 Paris, Département de Bactériologie, Hôpitaux Universitaires de l'Est Parisien, Centre National de Référence des Mycobactéries, Assistance Publique-Hôpitaux de Paris, 75012 PARIS, France.
    is a rare species of slow-growing nontuberculous mycobacteria (NTM).From 2002 to 2017, we conducted a retrospective study that included all patients with NTM-positive respiratory samples detected in two university hospitals of the French overseas department of Reunion Island. We recorded the prevalence of in this cohort, as well as the clinical, radiological, and microbiological features of patients with at least one sample positive for In our cohort, 97 patients (15. Read More

    What Immunological Defects Predispose to Non-tuberculosis Mycobacterial Infections?
    Iran J Allergy Asthma Immunol 2018 Apr;17(2):100-109
    Cell and Molecular Biology Group, Airways Disease Section, National Heart and Lung Institute, Imperial College London, London, UK.
    Nontuberculous mycobacteria (NTM) are categorized as one of the large and diverse groups of environmental organisms which are abundant in water and soil.  NTM cause a variety of diseases in humans that mainly affect the lung. A predisposition to pulmonary NTM is evident in patients with parenchymal structural diseases including bronchiectasis, emphysema, tuberculosis (TB), cystic fibrosis (CF), rheumatologic lung diseases and other chronic diseases with pulmonary manifestations. Read More

    A thiotrophic microbial community in an acidic brine lake in Northern Chile.
    Antonie Van Leeuwenhoek 2018 May 10. Epub 2018 May 10.
    Centro de Biotecnología, Universidad Católica del Norte, Antofagasta, Chile.
    The endorheic basins of the Northern Chilean Altiplano contain saline lakes and salt flats. Two of the salt flats, Gorbea and Ignorado, have high acidic brines. The causes of the local acidity have been attributed to the occurrence of volcanic native sulfur, the release of sulfuric acid by oxidation, and the low buffering capacity of the rocks in the area. Read More

    High mortality in patients with Mycobacterium avium complex lung disease: a systematic review.
    BMC Infect Dis 2018 May 3;18(1):206. Epub 2018 May 3.
    Department of pulmonary diseases, Geert Grooteplein Zuid 10, 6525, GA, Nijmegen, The Netherlands.
    Background: The incidence of nontuberculous mycobacterial (NTM) pulmonary disease caused by Mycobacterium avium complex (MAC) in apparently immune-competent people is increasing worldwide. We performed a systematic review of the published literature on five-year all-cause mortality in patients with MAC lung disease, and pooled the mortality rates to give an overall estimate of five-year mortality from these studies.

    Methods: We systematically reviewed the literature up to 1st August 2017 using PubMed® and ProQuest Dialog™ to search Medline® and Embase® databases, respectively. Read More

    Pulmonary Mycobacterial Spindle Cell Pseudotumor: A Report of 3 Cases Including a Practical Approach to Histopathologic Recognition of This Unusual Entity.
    Int J Surg Pathol 2018 May 1:1066896918770010. Epub 2018 May 1.
    1 Department of Pathology, University of Utah School of Medicine and Associated Regional and University Pathologists Laboratories, Salt Lake City, UT, USA.
    Mycobacterial spindle cell pseudotumor (MSP) is a rare benign spindle cell lesion containing acid-fact mycobacteria. These lesions are most commonly identified in the lymph nodes, skin, spleen, or bone marrow of immunocompromised patients and only rarely involve the lungs. We report 3 cases of pulmonary MSP, which include 2 patients who are known to be HIV-positive. Read More

    Microdeletion on chromosome 8p23.1 in a familial form of severe Buruli ulcer.
    PLoS Negl Trop Dis 2018 04 30;12(4):e0006429. Epub 2018 Apr 30.
    Laboratory of Human Genetics of Infectious Diseases, Necker Branch, Institut National de la Santé et de la Recherche Médicale (INSERM) UMR-1163, Paris, France.
    Buruli ulcer (BU), the third most frequent mycobacteriosis worldwide, is a neglected tropical disease caused by Mycobacterium ulcerans. We report the clinical description and extensive genetic analysis of a consanguineous family from Benin comprising two cases of unusually severe non-ulcerative BU. The index case was the most severe of over 2,000 BU cases treated at the Centre de Dépistage et de Traitement de la Lèpre et de l'Ulcère de Buruli, Pobe, Benin, since its opening in 2003. Read More

    HIV-negative pulmonary disease caused by nontuberculous mycobacteria in Southern Brazil: clinical and microbiological characterization.
    J Thorac Dis 2018 Mar;10(3):1903-1911
    Ribeirão Preto School of Medicine, University of São Paulo (FMRP-USP), Ribeirão Preto, Brazil.
    Background: Nontuberculous mycobacteria (NTM) have been identified with increasing frequency in the clinical practice. The aim of this study was to characterize NTM isolates in respiratory specimens from patients with pulmonary disease and to correlate this with clinical/radiological findings, decision to start treatment and outcomes.

    Methods: A cross-sectional descriptive study was performed and included all patients who had at least one NTM isolated in respiratory specimens between 2011 and 2014. Read More

    Mycobacterium chimaera in heater-cooler units used during cardiac surgery - growth and decontamination.
    Infect Dis (Lond) 2018 Apr 24:1-7. Epub 2018 Apr 24.
    d Department of Infectious Medicine , Institute of Biomedicine, University of Gothenburg , Göteborg , Sweden.
    Background: Previous studies have identified patients infected with Mycobacterium chimaera (M. chimaera) subsequent to cardiac surgery. Water tanks in heater-cooler units (HCUs) used cardiac heart surgery was traced as source. Read More

    New lipophilic isoniazid derivatives and their 1,3,4-oxadiazole analogues: Synthesis, antimycobacterial activity and investigation of their mechanism of action.
    Eur J Med Chem 2018 May 10;151:824-835. Epub 2018 Apr 10.
    Department of Organic and Bioorganic Chemistry, Faculty of Pharmacy in Hradec Králové, Charles University, Akademika Heyrovského 1203, 500 05, Hradec Králové, Czech Republic. Electronic address:
    The development of novel drugs is essential for the treatment of tuberculosis and other mycobacterial infections in future. A series of N-alkyl-2-isonicotinoylhydrazine-1-carboxamides was synthesized from isoniazid (INH) and then cyclized to N-alkyl-5-(pyridin-4-yl)-1,3,4-oxadiazole-2-amines. All derivatives were characterised spectroscopically. Read More

    Experimental platform utilising melting curve technology for detection of mutations in Mycobacterium tuberculosis isolates.
    Eur J Clin Microbiol Infect Dis 2018 Apr 20. Epub 2018 Apr 20.
    Infectious Diseases, Department of Medicine, Imperial College London, London, UK.
    Tuberculosis (TB) remains one of the most deadly infections with approximately a quarter of cases not being identified and/or treated mainly due to a lack of resources. Rapid detection of TB or drug-resistant TB enables timely adequate treatment and is a cornerstone of effective TB management. We evaluated the analytical performance of a single-tube assay for multidrug-resistant TB (MDR-TB) on an experimental platform utilising RT-PCR and melting curve analysis that could potentially be operated as a point-of-care (PoC) test in resource-constrained settings with a high burden of TB. Read More

    HadD, a novel fatty acid synthase type II protein, is essential for alpha- and epoxy-mycolic acid biosynthesis and mycobacterial fitness.
    Sci Rep 2018 Apr 16;8(1):6034. Epub 2018 Apr 16.
    Département Tuberculose & Biologie des Infections, Institut de Pharmacologie et de Biologie Structurale, UMR5089, Université de Toulouse, CNRS, UPS, 31077, Toulouse Cedex 04, France.
    Mycolic acids (MAs) have a strategic location within the mycobacterial envelope, deeply influencing its architecture and permeability, and play a determinant role in the pathogenicity of mycobacteria. The fatty acid synthase type II (FAS-II) multienzyme system is involved in their biosynthesis. A combination of pull-downs and proteomics analyses led to the discovery of a mycobacterial protein, HadD, displaying highly specific interactions with the dehydratase HadAB of FAS-II. Read More

    Non-tuberculous Mycobacterium species causing mycobacteriosis in farmed aquatic animals of South Africa.
    BMC Microbiol 2018 Apr 13;18(1):32. Epub 2018 Apr 13.
    Tuberculosis Laboratory, Agricultural Research Council - Onderstepoort Veterinary Research, Onderstepoort, South Africa.
    Background: Mycobacteriosis caused by non-tuberculous mycobacteria (NTM), is among the most chronic diseases of aquatic animals. In addition, fish mycobacteriosis has substantial economic consequences especially in the aquaculture and fisheries industry as infections may significantly decrease production and trade. Some fish NTM pathogens are highly virulent and zoonotic; as such, infection of aquaria with these pathogens is a public health concern. Read More

    Evaluation of the Vitek MS v3.0 Matrix-Assisted Laser Desorption Ionization-Time of Flight Mass Spectrometry System for Identification of Mycobacterium and Nocardia Species.
    J Clin Microbiol 2018 Jun 25;56(6). Epub 2018 May 25.
    ARUP Laboratories, Salt Lake City, Utah, USA
    This multicenter study was designed to assess the accuracy and reproducibility of the Vitek MS v3.0 matrix-assisted laser desorption ionization-time of flight (MALDI-TOF) mass spectrometry system for identification of and species compared to DNA sequencing. A total of 963 clinical isolates representing 51 taxa were evaluated. Read More

    Increasing nontuberculous mycobacteria reporting rates and species diversity identified in clinical laboratory reports.
    BMC Infect Dis 2018 Apr 10;18(1):163. Epub 2018 Apr 10.
    United States Environmental Protection Agency, 26 W. Martin Luther King Dr. Mail Stop 587, Cincinnati, Ohio, 45268, USA.
    Background: Nontuberculous Mycobacteria (NTM) are environmental microorganisms that can affect human health. A 2009-2010 occurrence survey of NTM in potable tap water samples indicated an increased recovery rate for many clinically significant species such as M. avium (30%) and M. Read More

    Surgical treatment for chronic cervical lymphadenitis in children. Experience from a tertiary care paediatric centre on non-tuberculous mycobacterial infections.
    Int J Pediatr Otorhinolaryngol 2018 May 2;108:137-142. Epub 2018 Mar 2.
    Pediatric Infectious Diseases Unit, Meyer Children's Hospital, Department of Pediatrics, University of Florence, Italy.
    Objectives: Non-tuberculous mycobacteria are the most frequent cause of chronic lymphadenitis in children. We reviewed treatment and outcomes of paediatric patients with chronic cervical lymphadenitis, to better understand their differential diagnosis, surgical indication, complication and recover.

    Methods: A retrospective study was carried out on children who underwent surgery from 2013 to 2016 at Meyer Children's University Hospital, Florence, Italy. Read More

    Bacterial pneumonia in kidney transplant recipients.
    Respir Med 2018 Apr 6;137:89-94. Epub 2018 Mar 6.
    Division of Nephrology, Cliniques universitaires Saint-Luc, Université catholique de Louvain, Brussels, Belgium. Electronic address:
    Bacterial pathogens are the most frequent cause of pneumonia after transplantation. Early after transplantation, recipients are at higher risk for nosocomial infections. The most commonly encountered pathogens during this period are gram-negative bacilli (Klebsiella pneumoniae, Escherichia coli, Pseudomonas aeruginosa …), but gram-positive coccus such as Staphylococcus aureus or Streptococcus pneumoniae and anaerobic bacteria can also be found. Read More

    Antimycobacterial potential of the juniper berry essential oil in tap water.
    Arh Hig Rada Toksikol 2018 Mar;69(1):46-54
    2Department of Microbiology and Parasitology, University of Rijeka, Rijeka, Croatia.
    Mycobacterium avium complex-related diseases are often associated with poorly maintained hot water systems. This calls for the development of new control strategies. The aim of this study was to investigate the activity of essential oils (EOs) from the Mediterranean plants, common juniper, immortelle, sage, lavandin, laurel, and white cedar against Mycobacterium avium ssp. Read More

    Exit Site Infection due to Mycobacterium chelonae in an Elderly Patient on Peritoneal Dialysis.
    Case Rep Nephrol Dial 2018 Jan-Apr;8(1):1-9. Epub 2018 Jan 19.
    aDivision of Nephrology and Rheumatology, Department of Internal Medicine, Kariya Toyota General Hospital, Kariya, Japan.
    Nontuberculous mycobacteria (NTM) are rarely isolated from peritoneal dialysis (PD)-associated catheter infections. However, NTM infection is usually difficult to treat and leads to catheter loss. Prompt diagnosis is essential for appropriate treatment. Read More

    Use of a Single Xpert MTB/RIF Assay to Determine the Duration of Airborne Isolation in Hospitalized Patients With Suspected Pulmonary Tuberculosis.
    Infect Control Hosp Epidemiol 2018 May 27;39(5):590-595. Epub 2018 Mar 27.
    1Division of Infectious Diseases,Department of Medicine,University of Maryland School of Medicine,Baltimore,Maryland.
    BACKGROUNDHospitalized patients with suspected tuberculosis (TB) are placed in airborne isolation until 3 sputum smear samples are negative for acid-fast bacilli (AFB). The Xpert MTB/RIF assay ("Xpert") nucleic acid amplification test (NAAT) to identify Mycobacterium tuberculosis DNA and resistance to rifampicin is superior to AFB sputum smear microscopy for the diagnosis of TB.OBJECTIVETo compare the performance of a single Xpert to AFB smear microscopy for time to airborne infection isolation (AII) discontinuation. Read More

    Nontuberculous mycobacterial empyema in an immunocompetent child.
    Indian J Pathol Microbiol 2018 Jan-Mar;61(1):141-142
    Department of Pediatrics, Pediatric TB Clinic, B. J. Wadia Hospital for Children, Mumbai, Maharashtra, India.
    Nontuberculous mycobacterium (NTM) species are mycobacterial species other than those belonging to the Mycobacterium Tuberculosis complex and Mycobacterium leprae. There are very few reports of NTM in immunocompetent children causing empyema. In this article, we report a 9-year-old immunocompetent girl who presented with Mycobacterium avium-intracellulare empyema. Read More

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