13,680 results match your criteria Mycobacterium Gordonae


A case of pulmonary infection in a healthy Japanese man.

Respir Med Case Rep 2020 16;30:101093. Epub 2020 May 16.

Division of Respirology, Neurology and Rheumatology, Department of Medicine, Kurume University School of Medicine, Fukuoka, 830-0011, Japan.

A 72-year-old man, healthy, smoker, with long-standing cough, was referred to our hospital and his chest X-ray (CXR) revealed a cavity lesion in the right upper lobe. Direct sputum smears, but not culture in solid medium, were positive for acid-fast bacilli (AFB) without tuberculosis DNA. The preliminary diagnosis was of a non-tuberculosis infection that progressed slowly, and the CXR showed the condition to worsen daily. Read More

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http://dx.doi.org/10.1016/j.rmcr.2020.101093DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7256317PMC

Antimycobacterial Activity of Laurinterol and Aplysin from .

Mar Drugs 2020 May 30;18(6). Epub 2020 May 30.

Facultad de Ciencias Biológicas (FCB), Universidad Autónoma de Nuevo León (UANL), Av. Pedro de Alba s/n, 66450 San Nicolás de los Garza, Nuevo León, Mexico.

Marine environments represent a great opportunity for the discovery of compounds with a wide spectrum of bioactive properties. Due to their large variety and functions derived from natural selection, marine natural products may allow the identification of novel drugs based not only on newly discovered bioactive metabolites but also on already known compounds not yet thoroughly investigated. Since drug resistance has caused an increase in infections by and nontuberculous mycobacteria, the re-evaluation of known bioactive metabolites has been suggested as a good approach to addressing this problem. Read More

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http://dx.doi.org/10.3390/md18060287DOI Listing

Nontuberculous Mycobacterial Disease and Molybdenum in Colorado Watersheds.

Int J Environ Res Public Health 2020 May 29;17(11). Epub 2020 May 29.

National Jewish Health, Denver, CO 80206, USA.

Nontuberculous mycobacteria (NTM) are environmental bacteria that may cause chronic lung disease. Environmental factors that favor NTM growth likely increase the risk of NTM exposure within specific environments. We aimed to identify water-quality constituents (Al, As, Cd, Ca, Cu, Fe, Pb, Mg, Mn, Mo, Ni, K, Se, Na, Zn, and pH) associated with NTM disease across Colorado watersheds. Read More

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http://dx.doi.org/10.3390/ijerph17113854DOI Listing

Clinical relevance and diagnosis of nontuberculous mycobacterial pulmonary disease in populations at risk.

J Formos Med Assoc 2020 May 29. Epub 2020 May 29.

Department of Chest Medicine, Taipei Veterans General Hospital, Taipei, Taiwan; Faculty of Medicine, School of Medicine, National Yang-Ming University, Taipei, Taiwan. Electronic address:

The lungs are the most common disease site of nontuberculous mycobacteria (NTM). However, the isolation of NTM in a respiratory specimen does not indicate lung disease (LD). Differentiation between NTM colonization and NTM-LD remains challenging. Read More

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http://dx.doi.org/10.1016/j.jfma.2020.05.012DOI Listing

Nontuberculous mycobacterial lung disease epidemiology in Taiwan: A systematic review.

J Formos Med Assoc 2020 May 30. Epub 2020 May 30.

Respiratory and Critical Care Center, Changhua Hospital, Ministry of Health & Welfare, Changhua, Taiwan. Electronic address:

Nontuberculous mycobacteria (NTM) are critical emerging global infectious pathogens. Though NTM can be mere colonizers when isolated from human specimens, NTM are also responsible for diverse human infections. NTM-lung disease (NTM-LD) is the most common human disease entity. Read More

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http://dx.doi.org/10.1016/j.jfma.2020.05.019DOI Listing

β-glucan in the lymph nodes in sarcoidosis and in Kveim-Siltzbach test reagent.

Sarcoidosis Vasc Diffuse Lung Dis 2017 28;34(2):130-135. Epub 2017 Apr 28.

BioFact Environmental Health Research Centre, Lerum, Sweden.

Previous studies have demonstrated a relationship between biomass of fungi exposure in the home and the risk of sarcoidosis. β-glucan was present in the bronchial alveolar lavage fluid (BALF) of patients with sarcoidosis. The Kveim-Siltzbach test reagent (KSTR) induces a sarcoidosis specific, granulomatous, cutaneous response and was used to establish the diagnosis. Read More

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http://dx.doi.org/10.36141/svdld.v34i2.5844DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7170140PMC

infection of the hand presenting as a nodular skin lesion.

J Clin Tuberc Other Mycobact Dis 2020 Aug 11;20:100166. Epub 2020 May 11.

Division of Clinical Microbiology, University of Pittsburgh and University of Pittsburgh Medical Center, Pittsburgh, PA, USA.

Nontuberculous mycobacteria have emerged as an important group of pathogens worldwide; however, infections of the hand are rare. Infections caused by nontuberculous mycobacteria are often opportunistic in humans, and notoriously difficult to treat due to intrinsic resistance to many antibiotics. Here we reported a case of infection of the hand in a patient who presented with a nodular skin lesion. Read More

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http://dx.doi.org/10.1016/j.jctube.2020.100166DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7248414PMC

Susceptibility of the complex to drying: Implications for nebulizer hygiene in patients with cystic fibrosis.

Int J Mycobacteriol 2020 Apr-Jun;9(2):173-175

Department of Bacteriology, Northern Ireland Public Health Laboratory, Belfast City Hospital, Belfast; School of Biomedical Sciences, Ulster University, Coleraine; School of Medicine, Dentistry and Biomedical Science, The Wellcome.Wolfson Institute for Experimental Medicine, Queenfs University, Belfast, Northern Ireland.

Background: Nebulizer hygiene and care is important in cystic fibrosis (CF) to minimize device contamination from bacteria, including nontuberculous mycobacteria (NTMs). Most nebulizer manufacturers recommend nebulizer drying, however there is little evidence to understand how nebulizer drying affects NTM survival.

Methods: Mycobacterium abscessus subsp. Read More

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http://dx.doi.org/10.4103/ijmy.ijmy_62_20DOI Listing

VapBC and MazEF toxin/antitoxin systems in the regulation of biofilm formation and antibiotic tolerance in nontuberculous mycobacteria.

Int J Mycobacteriol 2020 Apr-Jun;9(2):156-166

Institute of Ecology and Genetic of Microorganisms, Perm Federal Research Center, Ural Branch RAS, Perm, Russia.

Background: Mycobacterium smegmatis and other nontuberculous mycobacteria (NTM) are widely distributed in the environment, but a significant increase of NTM infections has taken place in the last few decades. The objective of this study was to determine the role of toxin-antitoxin (TA) vapBC and mazEF systems that act as effectors of persistence in the stress response of NTM.

Methods: The growth ability and the biofilm formation of NTM were evaluated by conventional methods. Read More

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http://dx.doi.org/10.4103/ijmy.ijmy_61_20DOI Listing

Persistent Laparoscopic Port-site Discharging Sinus: A Rare Case of Mycobacterium senegalense Infection.

Int J Mycobacteriol 2020 Jan-Mar;9(1):100-102

Department of Medicine, ABVIMS and Dr. R M L Hospital, New Delhi, India.

Laparoscopic port-site infections, though infrequent, undermine the advantages provided by minimally invasive surgeries. Persistent nonhealing discharging sinuses, not responding to conventional antibiotic therapy, pose diagnostic and therapeutic challenges. Sizeable number of these infections is caused by rapidly growing nontuberculous mycobacteria (NTM), and diagnosing these requires a high index of suspicion. Read More

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http://dx.doi.org/10.4103/ijmy.ijmy_189_19DOI Listing

Clinical-epidemiological profile and factors related to the mortality of patients with nontuberculous mycobacteria isolated at a reference hospital in Ceará, Northeastern Brazil.

Int J Mycobacteriol 2020 Jan-Mar;9(1):83-90

São José Hospital of Infectious Diseases; Department of Community Health, School of Medicine, Federal University of Ceará, Fortaleza, Ceará, Brazil.

Background: There is a significant shortage of official records that enable estimating the real prevalence of nontuberculous mycobacteria (NTM) infections in Brazil. The study aims to investigate the clinical, laboratory, and epidemiological aspects of patients with NTM isolation at an infectious diseases reference hospital, and to identify factors associated with mortality.

Methods: This was an observational study in which clinical, epidemiological, and laboratory aspects were evaluated in patients with NTM isolated at care in Hospital São José, located in Northeastern Brazil, from 2005 to 2016. Read More

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http://dx.doi.org/10.4103/ijmy.ijmy_12_20DOI Listing

Serum immunoglobulin a antibodies to glycopeptidolipid core antigen for complex lung disease.

Int J Mycobacteriol 2020 Jan-Mar;9(1):76-82

Department of Internal Medicine, National Hospital Organization, Kinki-Chuo Chest Medical Center, Sakai City, Osaka, Japan.

Background: Mycobacteroides abscessus complex (MABC) exhibits smooth morphotypes, expressing glycopeptidolipid (GPL), and rough morphotypes, expressing diminished GPL, on the MABC cell wall. Few reports have focused on the relationship between anti-GPL-core immunoglobulin A (IgA) antibody and colony morphology in MABC lung disease.

Methods: This study aimed to test GPL core antigen in patients with MABC lung disease to investigate the relationship between coinfection/contamination in other nontuberculous mycobacteria species and colony morphology variant in MABC isolates. Read More

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http://dx.doi.org/10.4103/ijmy.ijmy_14_20DOI Listing

An overview of pulmonary infections due to rapidly growing mycobacteria in South Asia and impressions from a subtropical region.

Int J Mycobacteriol 2020 Jan-Mar;9(1):62-70

Department of Microbiology, Vallabhbhai Patel Chest Institute, University of Delhi, Delhi, India.

Background: Rapidly growing mycobacteria (RGM) comprise nearly half of the validated species of nontuberculous mycobacteria (NTM) and have been reported to have a higher incidence in Asia as compared to Europe and America. There is limited information on RGM infections from South Asia. Hence, the present study aimed to ascertain the incidence of pulmonary infections due to RGM in Delhi and to review the status of available information on the prevalence of RGM in South Asia, a region endemic for tuberculosis. Read More

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http://dx.doi.org/10.4103/ijmy.ijmy_179_19DOI Listing

Outcomes of pulmonary infection.

Int J Mycobacteriol 2020 Jan-Mar;9(1):48-52

Oxford Adult Cystic Fibrosis Centre, Oxford University Hospitals NHS Foundation Trust; University of Oxford, Oxford, UK.

Background: Treatment of Mycobacterium abscessus pulmonary disease (PD) is challenging with frequent side effects and uncertain rates of success.

Methods: We performed a retrospective review of all patients at our center with at least one respiratory sample positive for M. abscessus between 2014 and 2019. Read More

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http://dx.doi.org/10.4103/ijmy.ijmy_3_20DOI Listing

Prevalence of paratuberculosis in dairy cattle in ecuador.

Int J Mycobacteriol 2020 Jan-Mar;9(1):1-6

One Health Research Group, Facultad de Ciencias de la Salud, Universidad de Las Américas, Quito, Ecuador, Departamento de Tuberculosis, Instituto de Biomedicina Jacinto Convit, Universidad Central de Venezuela, Caracas, Venezuela.

Background: Mycobacterium avium subsp. paratuberculosis (MAP) is the causal agent of paratuberculosis, a chronic infectious contagious disease of the intestinal tract of ruminants that are also associated with Crohn's disease in humans. The existence of paratuberculosis in Ecuador is virtually unknown; hence, the present study was performed to gain insight into the prevalence of this disease. Read More

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http://dx.doi.org/10.4103/ijmy.ijmy_175_19DOI Listing

Nontuberculous mycobacterial bloodstream infections after allogeneic hematopoietic stem cell transplantation.

Int J Infect Dis 2020 May 28. Epub 2020 May 28.

Hematology Division, Tokyo Metropolitan Cancer and Infectious Diseases Center Komagome Hospital, Tokyo, Japan.

Non-tuberculous mycobacteria (NTM) bacteremia following allogeneic hematopoietic stem cell transplantation (allo-HSCT) is rare, and limited data exist. We described the features of NTM bacteremia following allo-HSCT recipients in our hospital with a comprehensive review of the literature. Among the four cases of NTM bacteremia after allo-HSCT recipients in our hospital, two were catheter-related bloodstream infections (CRBSI), one was disseminated, and one was an unknown source of infection. Read More

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http://dx.doi.org/10.1016/j.ijid.2020.05.079DOI Listing

Mycobacterium abscessus-associated vertebral osteomyelitis in an immunocompetent patient: a rare case report and literature review.

Spinal Cord Ser Cases 2019 May 31;5(1):53. Epub 2019 May 31.

Division of Orthopedic Surgery, Albany Medical College, Albany, NY, USA.

Introduction: Vertebral osteomyelitis (VO) is an uncommon infection with Staphylococcus aureus as the most commonly implicated organism. VO caused by nontuberculous mycobacteria (NTM) such as Mycobacterium abscessus (M. abscesscus) is exceedingly rare with only eight cases reported in literature. Read More

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http://dx.doi.org/10.1038/s41394-019-0197-5DOI Listing

Crohn's Disease Patient Infected With Multiple Co-occurring Nontuberculous Mycobacteria.

Inflamm Bowel Dis 2020 May 27. Epub 2020 May 27.

Pathogen Genomics Laboratory, Biological and Environmental Sciences and Engineering Division, King Abdullah University of Science and Technology (KAUST), Thuwal-Jeddah, Saudi Arabia.

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http://dx.doi.org/10.1093/ibd/izaa100DOI Listing

Host immune response against environmental nontuberculous mycobacteria and the risk populations of nontuberculous mycobacterial lung disease.

J Formos Med Assoc 2020 May 22. Epub 2020 May 22.

Division of Pulmonary and Critical Care Medicine, Department of Medicine, Kaohsiung Chang Gung Memorial Hospital, Chang Gung University College of Medicine, Kaohsiung 83301, Taiwan.

Nontuberculous mycobacterial lung disease (NTM-LD) prevalence has been increasing over the recent decades. Numerous host factors are associated with NTM-LD development, including susceptible phenotypes such as ciliary defect and lung structural change, pulmonary clearance defect with poor clearance of secretions, and immune suppression. Specifically, regarding the susceptible host phenotypes without clear pathogenesis, a slender body, pectus excavatum, and postmenopausal female status are common. Read More

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http://dx.doi.org/10.1016/j.jfma.2020.05.001DOI Listing

Successful bedaquiline-containing antimycobacterial treatment in post-traumatic skin and soft-tissue infection by Mycobacterium fortuitum complex: a case report.

BMC Infect Dis 2020 May 24;20(1):365. Epub 2020 May 24.

Technical University of Munich, School of Medicine, University Hospital Rechts der Isar, Department of Internal Medicine II, Ismaningerstrasse 22, 81675, Munich, Germany.

Background: Mycobacterium fortuitum complex is a group of rapidly growing nontuberculous mycobacteria (NTM) associated with skin and soft-tissue infections after surgery or trauma. Treatment of NTM is challenging, due to resistance to multiple antimycobacterial agents. Bedaquiline is a diarylquinoline that inhibits mycobacterial ATP-synthase. Read More

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http://dx.doi.org/10.1186/s12879-020-05075-7DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7245858PMC

Treatment for Mycobacterium avium complex lung disease.

J Formos Med Assoc 2020 May 20. Epub 2020 May 20.

Department of Chest Medicine, Taipei Veterans General Hospital, Taipei, Taiwan; School of Medicine, National Yang-Ming University, Taipei, Taiwan. Electronic address:

Mycobacterium avium complex (MAC) is the major pathologic nontuberculous mycobacteria causing lung disease (LD) in humans worldwide. Although the burden of MAC-LD has increased over the past two decades, treatment remains difficult because of intolerance of long-term antibiotics, lack of adherence to guidelines, and disease recurrence. The current guidelines recommend antibiotic initiation for patients with MAC-LD and severe disease and in those with disease progression. Read More

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http://dx.doi.org/10.1016/j.jfma.2020.05.006DOI Listing

Mycobacterial Infections Potentiated by Biologics.

Infect Dis Clin North Am 2020 Jun;34(2):413-423

Division of Infectious Diseases, Schools of Medicine and Public Health, Oregon Health and Science University, OHSU, 3181 Sam Jackson Road, Mail Code: Gaines Hall, Portland, OR 97239, USA.

Biologic therapies have revolutionized the treatment of immune-mediated inflammatory diseases but are associated with an increased risk of serious and opportunistic infections, including tuberculosis and nontuberculous mycobacterial disease. Despite this increased risk, the overall risk-benefit ratio remains favorable with appropriate screening and risk assessment. Further population-based studies are needed to establish the risk of tuberculosis and nontuberculous mycobacterial disease with the new biologics. Read More

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http://dx.doi.org/10.1016/j.idc.2020.02.011DOI Listing

Nontuberculous mycobacterial infection in a tertiary care center in Mexico, 2001-2017.

Braz J Infect Dis 2020 May 16. Epub 2020 May 16.

Instituto Nacional de Ciencias Médicas y Nutrición Salvador Zubirán, Department of Infectious Diseases, Laboratory of Clinical Microbiology, Mexico City, Mexico. Electronic address:

Introduction: Nontuberculous mycobacteria (NTM) comprise several pathogens with a complex profile of virulence, diverse epidemiological and clinical patterns as well as host specificity. Recently, an increase in the number of NTM infections has been observed; therefore, the objective of this study was to evaluate the clinical characteristics and outcomes of these infections.

Methods: We included patients with NTM infections between 2001-2017 and obtained risk factors, clinical features and outcomes; finally, we compared this data between slowly growing (SGM) and rapidly growing mycobacteria (RGM). Read More

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http://dx.doi.org/10.1016/j.bjid.2020.04.012DOI Listing

clearance by neutrophils is independent of autophagy.

Infect Immun 2020 May 18. Epub 2020 May 18.

Department of Medicine, National Jewish Health, Denver, CO, USA

, a rapidly growing nontuberculous mycobacteria, is increasingly prevalent in chronic lung disease, including cystic fibrosis, and infections are characterized by neutrophil-dominated environments. However, mechanisms of immune control are poorly understood. Azithromycin, a macrolide antibiotic with immunomodulatory effects, is used to treat infections. Read More

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http://dx.doi.org/10.1128/IAI.00024-20DOI Listing

Identification and drug susceptibility testing for nontuberculous mycobacteria.

J Formos Med Assoc 2020 May 16. Epub 2020 May 16.

Division of Chest Medicine, Department of Internal Medicine, Chang-Hua Hospital, Ministry of Health and Welfare, Chang-Hua, 513, Taiwan; Institute of Medicine, Chang-Shan Medical University, Taichung 402, Taiwan. Electronic address:

Great progress has recently been made in methodologies for identifying nontuberculous mycobacteria (NTM). Recommendations for drug susceptibility testing (DST) of NTM have been expanded and updated by the Clinical and Laboratory Standards Institute and are crucial in the management of NTM infections. This article summarizes the clinically relevant molecular methods used to discriminate NTM species and updates the information on DST. Read More

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http://dx.doi.org/10.1016/j.jfma.2020.05.002DOI Listing

Clinical outcomes in Mycobacterium xenopi versus Mycobacterium avium complex pulmonary disease: A retrospective matched cohort study.

Respir Med 2020 Jun 15;167:105967. Epub 2020 Apr 15.

Division of Respirology, Department of Medicine, University of Toronto, Toronto, Canada; Division of Respirology, Department of Medicine, Toronto Western Hospital, Toronto, Canada.

Mycobacterium xenopi is associated with the highest mortality among pulmonary nontuberculous mycobacterial (NTM) infections, but whether this is due to the infection or other factors is unclear. There is little information regarding outcomes among patients infected with M. xenopi versus other NTM species. Read More

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http://dx.doi.org/10.1016/j.rmed.2020.105967DOI Listing

-Alkyl-2-[4-(trifluoromethyl)benzoyl]hydrazine-1-carboxamides and Their Analogues: Synthesis and Multitarget Biological Activity.

Molecules 2020 May 12;25(10). Epub 2020 May 12.

Department of Organic and Bioorganic Chemistry, Faculty of Pharmacy in Hradec Králové, Charles University, Akademika Heyrovského 1203, 500 05 Hradec Králové, Czech Republic.

Based on the isosterism concept, we have designed and synthesized homologous -alkyl-2-[4-(trifluoromethyl)benzoyl]hydrazine-1-carboxamides (from C to C) as potential antimicrobial agents and enzyme inhibitors. They were obtained from 4-(trifluoromethyl)benzohydrazide by three synthetic approaches and characterized by spectral methods. The derivatives were screened for their inhibition of acetylcholinesterase (AChE) and butyrylcholinesterase (BuChE) via Ellman's method. Read More

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http://dx.doi.org/10.3390/molecules25102268DOI Listing

ISOLATION AND ANTIMICROBIAL SUSCEPTIBILITIES OF NONTUBERCULOUS MYCOBACTERIA FROM WILDLIFE IN JAPAN.

J Wildl Dis 2020 May 13. Epub 2020 May 13.

Department of Applied Veterinary Sciences, United Graduate School of Veterinary Sciences, Gifu University, 1-1 Yanagido, Gifu 501-1193, Japan.

Nontuberculous mycobacteria (NTM) are opportunistic pathogens of humans and animals and are transmitted among the environment, wildlife, livestock, and humans. The aim of this study was to investigate the rate of isolation and antimicrobial susceptibility of NTM in wildlife. In total, 178 samples of feces (=131) and tissues (=47) were collected from 11 wildlife species in Gifu Prefecture and Mie Prefecture, Japan, between June 2016 and October 2018. Read More

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http://dx.doi.org/10.7589/2019-10-261DOI Listing

Nontuberculous mycobacteria in patients with suspected tuberculosis and the genetic diversity of Mycobacterium avium in the extreme south of Brazil.

J Bras Pneumol 2020 11;46(2):e20190184. Epub 2020 May 11.

Núcleo de Pesquisa em Microbiologia Médica, Faculdade de Medicina, Universidade Federal do Rio Grande, Rio Grande, RS, Brazil.

Objective: Nontuberculous mycobacteria (NTM) are a heterogeneous group of bacteria that are widely distributed in nature and associated with opportunistic infections in humans. The aims of this study were to identify NTM in patients with suspected tuberculosis who presented positive cultures and to evaluate the genetic diversity of strains identified as Mycobacterium avium.

Methods: We studied pulmonary and extrapulmonary samples obtained from 1,248 patients. Read More

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http://dx.doi.org/10.36416/1806-3756/e20190184DOI Listing

Nontuberculous mycobacteria infections of peritoneal dialysis patients: A multicenter study.

Perit Dial Int 2020 May 13:896860820923461. Epub 2020 May 13.

Infectious Diseases Unit, Shaare Zedek Medical Center, Affiliated with the Hebrew University, Jerusalem, Israel.

Objectives: Nontuberculous mycobacteria (NTM) infections pose a diagnostic challenge in peritoneal dialysis (PD) patients. In this study, we sought to identify findings that are suggestive of NTM infection in PD adult patients.

Methods: All patients with NTM exit-site infection (ESI) with/without tunnel infection and peritonitis identified during the last decade in eight medical centers in Israel were included. Read More

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http://dx.doi.org/10.1177/0896860820923461DOI Listing

Exposure of to Environmental Stress and Clinically Used Antibiotics Reveals Common Proteome Response among Pathogenic Mycobacteria.

Microorganisms 2020 May 9;8(5). Epub 2020 May 9.

Department of Biomedical Sciences, Carlson College of Veterinary Medicine, Oregon State University, Corvallis, OR 97331, USA.

subsp. (MAB) is a clinically important nontuberculous mycobacterium (NTM) causing pulmonary infection in patients such as cystic fibrosis and bronchiectasis. MAB is naturally resistant to the majority of available antibiotics. Read More

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http://dx.doi.org/10.3390/microorganisms8050698DOI Listing

Insights into the L,D-transpeptidases and D,D-carboxypeptidase of ceftaroline, imipenem and novel diazabicyclooctanes inhibitors.

Antimicrob Agents Chemother 2020 May 11. Epub 2020 May 11.

Research Service, Louis Stokes Cleveland Department of Veterans Affairs Medical Center, Cleveland, Ohio, USA.

(Mab) is a highly drug-resistant nontuberculous mycobacteria (NTM). Efforts to discover new treatments for infections are accelerating with a focus on cell wall synthesis proteins (L, D-transpeptidases, Ldt, and D,D-carboxypeptidase) that are targeted by β-lactam antibiotics. A challenge to this approach is the presence of chromosomally encoded β-lactamase, Bla Using a "mechanism based" approach, we show that a novel ceftaroline-imipenem combination effectively lowered the minimal inhibitory concentrations (MICs) of Mab isolates (MIC ≤ 0. Read More

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http://dx.doi.org/10.1128/AAC.00098-20DOI Listing

Recent advances and controversies in surgical intervention of nontuberculous mycobacterial lung disease: A literature review.

J Formos Med Assoc 2020 May 6. Epub 2020 May 6.

Department of Surgery, National Taiwan University Hospital and National Taiwan University College of Medicine, Taipei, Taiwan; Thoracic Medicine Center, Department of Medicine and Surgery, National Taiwan University Hospital Yunlin Branch, Yunlin County, Taiwan. Electronic address:

The prevalence of nontuberculous mycobacterial lung disease (NTM-LD) has increased in Western and Asian nations in recent decades. While surgery may improve the outcome of more complex cases, many inconsistencies exist in the current literature regarding the management, growing emergence, and challenges of drug-resistant forms of NTM-LD, the indications and timing of surgical treatment, and perioperative multimodal therapy of NTM-LD. Moreover, data regarding the comparative treatments, risk factors of pulmonary resection for NTM-LD, and the long-term outcomes of microbiological recurrence are limited. Read More

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http://dx.doi.org/10.1016/j.jfma.2020.04.029DOI Listing

Effectiveness and Safety of Omalizumab in Patients with Allergic Bronchopulmonary Aspergillosis Complicated by Chronic Bacterial Infection in the Airways.

Int Arch Allergy Immunol 2020 May 8:1-8. Epub 2020 May 8.

Division of Pulmonary Medicine, Department of Medicine, Tokai University School of Medicine, Kanagawa, Japan,

Background: Allergic bronchopulmonary aspergillosis (ABPA) develops in the presence of predisposing conditions such as asthma and cystic fibrosis. Even ABPA accompanied by asthma is often complicated by chronic Pseudomonas aeruginosa or nontuberculous mycobacterial infection of the lower respiratory tract, rendering treatment with corticosteroids difficult. There have been several reports on the effectiveness of omalizumab, an anti-IgE antibody, in patients with ABPA. Read More

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http://dx.doi.org/10.1159/000507216DOI Listing

Characteristics of Circulating CD4 T Cell Subsets in Patients with Complex Pulmonary Disease.

J Clin Med 2020 May 3;9(5). Epub 2020 May 3.

Division of Pulmonary and Critical Care Medicine, Department of Medicine, Samsung Medical Center, Sungkyunkwan University School of Medicine, Seoul 06351, Korea.

Although prevalence of complex pulmonary disease (MAC-PD) is increasing, limited data are available regarding vulnerability to complex (MAC) infections. To understand the pathobiology of interaction between MAC and host-immunity, it is important to understand the characteristics for circulating T cells in terms of the immunological phenotype and functional correlates in MAC-PD. We aimed to characterize immunophenotype, cytokine profile, and immune inhibitory receptors of circulating CD4 T cells in MAC-PD patients. Read More

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http://dx.doi.org/10.3390/jcm9051331DOI Listing

Pulmonary Disease Progressed to Pleuritis after Iatrogenic Pneumothorax: A Case Report.

J Clin Tuberc Other Mycobact Dis 2020 May 21;19:100160. Epub 2020 Apr 21.

Division of Pulmonary Medicine, National Hospital Organization Kochi Hospital, 1-2-25 Asakuranishimachi, Kochi 780-8077, Japan.

is a newly identified nontuberculous mycobacteria (NTM) and its gene sequence of 16S rRNA shows high homology to that of . We present a case of pulmonary disease progressed to pleuritis after iatrogenic pneumothorax. The patient was initially diagnosed as tuberculosis based on a positive result for the 16S rRNA of an identification kit using scrapings from the cavitary nodule. Read More

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http://dx.doi.org/10.1016/j.jctube.2020.100160DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7191214PMC

mimicking tubercular spondylodiscitis following ozone therapy: A case report and review of literature.

Surg Neurol Int 2020 4;11:63. Epub 2020 Apr 4.

Department of Ortho-Spine Surgery, Sir Ganga Ram Hospital, New Delhi, Delhi, India.

Background: The incidence of (MA), a rapidly growing species of nontuberculous mycobacteria (NTM)-related infections, has been steadily rising over the past decade. Despite the increased prevalence of NTM-related infections, it is largely underreported from TB-endemic countries due to lack of awareness and limited laboratory facilities. Here, we report a rare case of L4-L5 spondylodiscitis caused by MA following ozone therapy (a noncondoned method of lumbar disc management). Read More

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http://dx.doi.org/10.25259/SNI_50_2019DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7193194PMC

Cutaneous nocardiosis in a liver transplant recipient - case report.

Pol Merkur Lekarski 2020 Apr;48(284):108-111

Medical University of Warsaw, Poland: Department of Transplantation Medicine, Nephrology and Internal Medicine.

Solid organ transplant recipients are specific group due to taken immunosuppressive agents. This can result in side effects including infections caused by rare opportunistic pathogens.

A Case Report: A 64-year old woman after orthotopic liver transplantation due to primary biliary cirrhosis and autoimmune hepatitis was admitted to hospital because of several infections. Read More

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Cefoxitin-Serum Creatinine Interference in a Patient With Nontuberculous Ventriculomeningitis.

J Pharm Pract 2020 Apr 30:897190020921613. Epub 2020 Apr 30.

Department of Pathology and Laboratory Medicine, Medical University of South Carolina, Charleston, SC, USA.

Cefoxitin is a second-generation cephamycin antibiotic, which at concentrations ≥100 µg/mL is known to modestly interfere, for up to 2 hours post-infusion, with serum creatinine measurement via the traditional Jaffe-based assay. We report a case of a severe serum creatinine elevation while utilizing cefoxitin as a component of an antimicrobial regimen in a critically ill patient with ventriculomeningitis. Our results, both via patient serum analysis and a cefoxitin spiking experiment, demonstrate interference despite the utilization of improved modern Jaffe-based assays. Read More

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http://dx.doi.org/10.1177/0897190020921613DOI Listing

Is a Safe and Non-Toxic Immunomodulatory Agent for Cancer Treatment.

Vaccines (Basel) 2020 Apr 25;8(2). Epub 2020 Apr 25.

Departament de Genètica i de Microbiologia, Facultat de Biociències, Universitat Autònoma de Barcelona, 08193 Barcelona, Spain.

Intravesical Bacillus Calmette-Guérin (BCG) immunotherapy remains the gold-standard treatment for non-muscle-invasive bladder cancer patients, even though half of the patients develop adverse events to this therapy. On exploring BCG-alternative therapies, , a nontuberculous mycobacterium, has shown outstanding anti-tumor and immunomodulatory capabilities. As no infections due to in humans, animals, or plants have been described, the safety and/or toxicity of this mycobacterium have not been previously addressed. Read More

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http://dx.doi.org/10.3390/vaccines8020198DOI Listing

Nontuberculous Mycobacterial Infection in Patients with Neurosurgical Hardware: Two Cases and A Review of the Literature.

Cureus 2020 Mar 24;12(3):e7398. Epub 2020 Mar 24.

Neurological Surgery, Penn State Milton S. Hershey Medical Center, Hershey, USA.

Central nervous system infections with nontuberculous mycobacteria (NTM) are rare but have been increasing in frequency. A small fraction of these infections are related to surgical hardware, with approximately 20 cases reported. Patients typically present with an indolent course but can rapidly deteriorate. Read More

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http://dx.doi.org/10.7759/cureus.7398DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7179971PMC

Assessment of current diagnostic algorithm for detection of mixed infection with Mycobacterium tuberculosis and nontuberculous mycobacteria.

J Infect Public Health 2020 Apr 22. Epub 2020 Apr 22.

National Clinical Laboratory on Tuberculosis, Beijing Key Laboratory on Drug-resistant Tuberculosis Research, Beijing Chest Hospital, Capital Medical University, Beijing Tuberculosis and Thoracic Tumor Institute, Beijing, China. Electronic address:

Background: The increasing pulmonary diseases are reported to be affected by mixed infection of Mycobacterium tuberculosis (MTB) and nontuberculous mycobacteria (NTM). In this study, our objective was to assess the efficiency of mycobacterial culture plus DNA sequencing to detect the mixed infections with MTB and various NTM organisms. We also aimed to investigate how efficiently GeneXpert detected MTB in mixed infections with NTM in in vitro models. Read More

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http://dx.doi.org/10.1016/j.jiph.2020.03.017DOI Listing

KatG as Counterselection Marker for Nontuberculous Mycobacteria.

Antimicrob Agents Chemother 2020 Apr 21;64(5). Epub 2020 Apr 21.

Institute of Medical Microbiology, University of Zurich, Zurich, Switzerland

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http://dx.doi.org/10.1128/AAC.02508-19DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7179591PMC

Odontogenic cutaneous sinus tracts due to infection with nontuberculous mycobacteria: a report of three cases.

BMC Infect Dis 2020 Apr 21;20(1):295. Epub 2020 Apr 21.

Departamento Laboratorio de Tuberculosis. Instituto de Biomedicina "Dr. Jacinto Convit", Universidad Central de Venezuela, Caracas, Venezuela.

Background: Soft tissue or skin infections due to nontuberculous mycobacteria (NTM) have been reported frequently and are mostly associated with trauma or cosmetic interventions like plastic surgery. However, infection with NTM as a result of a dental procedure have rarely been described and the lack of clinical suspicion and a clear clinical manifestation makes diagnosis challenging.

Case Presentation: We report on three patients with a facial cutaneous sinus tract of dental origin, due to an infection with respectively Mycobacterium fortuitum, M. Read More

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http://dx.doi.org/10.1186/s12879-020-05015-5DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7171849PMC

Species Distribution and Isolation Frequency of Nontuberculous Mycobacteria, Uruguay.

Emerg Infect Dis 2020 May;26(5):1014-1018

Nontuberculous mycobacteria (NTM) increasingly are recognized as opportunistic pathogens of humans. NTM species distribution is well documented in Europe and North America, but data from other regions are scarce. We assessed NTM isolation frequency and species distribution in Uruguay during 2006-2018. Read More

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http://dx.doi.org/10.3201/eid2605.191631DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7181928PMC
May 2020
6.751 Impact Factor

and Gastroesophageal Reflux: An Study.

Am J Respir Crit Care Med 2020 Apr 16. Epub 2020 Apr 16.

National Jewish Health, 2930, Center for Genes, Environment, and Health, Denver, Colorado, United States;

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http://dx.doi.org/10.1164/rccm.202001-0011LEDOI Listing

[Mycobacterium abscessus complex representatives in patients with bronchopulmonary pathology: prevalence, peculiarities of cultivation and identification.]

Klin Lab Diagn 2020 ;65(5):316-320

Samara State Medical University, 443099, Samara, Russia.

More and more publications appear in the modern literature on the increase in the prevalence of non-tuberculous mycobacteria (NTMs), in particular, representatives of M. chelonae / Mycobacterium abscessus complex (MABSc). The paper presents data on the current classification of M. Read More

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http://dx.doi.org/10.18821/0869-2084-2020-65-5-316-320DOI Listing
January 2020