2,180 results match your criteria Mycobacterium Fortuitum


Phenotypic and genomic hallmarks of a novel, potentially pathogenic rapidly growing Mycobacterium species related to the Mycobacterium fortuitum complex.

Sci Rep 2021 Jun 21;11(1):13011. Epub 2021 Jun 21.

Unit of Typing & Genetics of Mycobacteria, Laboratory of Molecular Microbiology, Vaccinology, and Biotechnology Development, Institut Pasteur de Tunis, Université de Tunis El Manar, Tunis, Tunisia.

Previously, we have identified a putative novel rapidly growing Mycobacterium species, referred to as TNTM28, recovered from the sputum of an apparently immunocompetent young man with an underlying pulmonary disease. Here we provide a thorough characterization of TNTM28 genome sequence, which consists of one chromosome of 5,526,191 bp with a 67.3% G + C content, and a total of 5193 predicted coding sequences. Read More

View Article and Full-Text PDF

A Series of Tattoo-associated Infections.

J Clin Aesthet Dermatol 2021 Apr 1;14(4):38-40. Epub 2021 Apr 1.

Dr. Schlesinger is with the Dermatology & Laser Center of Charleston and the Clinical Research Center of the Carolinas in Charleston, South Carolina.

is a rapidly growing mycobacterium known to spread through many sources, including tap water. This organism can have variable presentation between patients which can lead to a delay in diagnosis. Here, we report a series of eight cases of tattoo-associated infections that presented between December 2010 and January 2011, which were later linked to a single tattoo provider using gray tattoo ink made by diluting black ink with nonsterile tap water. Read More

View Article and Full-Text PDF

Suppurative Arthritis Induced by Scedosporium apiospermum and Mycobacterium fortuitum: a Case Report.

Clin Lab 2021 May;67(5)

Background: Suppurative arthritis induced by Scedosporium apiospermum (S. apiospermum) or Mycobacterium fortuitum (MF) was rare, and even more so when caused by a mixed infection of the two. In this paper, we report the rare case of suppurative arthritis induced by S. Read More

View Article and Full-Text PDF

Analysis of the Lipid Composition of Mycobacteria by Thin Layer Chromatography.

J Vis Exp 2021 04 16(170). Epub 2021 Apr 16.

Departament de Genètica i de Microbiologia, Facultat de Biociències, Universitat Autònoma de Barcelona;

Mycobacteria species can differ from one another in the rate of growth, presence of pigmentation, the colony morphology displayed on solid media, as well as other phenotypic characteristics. However, they all have in common the most relevant character of mycobacteria: its unique and highly hydrophobic cell wall. Mycobacteria species contain a membrane-covalent linked complex that includes arabinogalactan, peptidoglycan, and long-chains of mycolic acids with types that differ between mycobacteria species. Read More

View Article and Full-Text PDF

M. fortuitum-induced CNS-pathology: Deciphering the role of canonical Wnt signaling, blood brain barrier components and cytokines.

Dev Comp Immunol 2021 Sep 29;122:104111. Epub 2021 Apr 29.

Immunobiology Laboratory, Department of Zoology, University of Delhi, Delhi, 110007, India; Faculty of Life Sciences and Biotechnology, South Asian University, Delhi, 110021, India. Electronic address:

Molecular underpinning of mycobacteria-induced CNS-pathology is not well understood. In the present study, zebrafish were infected with Mycobacterium fortuitum and the prognosis of CNS-pathogenesis studied. We observed M. Read More

View Article and Full-Text PDF
September 2021

Gene Sequencing and Phylogenetic Analysis: Powerful Tools for an Improved Diagnosis of Fish Mycobacteriosis Caused by Group Members.

Microorganisms 2021 Apr 10;9(4). Epub 2021 Apr 10.

Istituto Zooprofilattico Sperimentale del Piemonte, Liguria e Valle d'Aosta, Via Bologna 148, 10154 Torino, Italy.

The group (MFG) consists of about 15 species of fast-growing nontuberculous mycobacteria (NTM). These globally distributed microorganisms can cause diseases in humans and animals, especially fish. The increase in the number of species belonging to MFG and the diagnostic techniques panel do not allow to clarify their real clinical significance. Read More

View Article and Full-Text PDF

Treatment of mycobacteriosis in a patient with compatible symptoms after a cesarean delivery.

Rev Inst Med Trop Sao Paulo 2021 23;63:e37. Epub 2021 Apr 23.

Universidade Federal de Pernambuco, Departamento de Medicina Tropical, Recife, Pernambuco, Brazil.

This study aims to report the diagnostic course and treatment of a fast-growing mycobacteria infection after cesarean delivery. We report the case of a 37-year-old woman admitted to the Infectious Diseases' Clinic of the Hospital das Clinicas da Universidade Federal de Pernambuco, Pernambuco State, Brazil, four months after a cesarean section, presenting with healing difficulties and located pain outside the surgical site. The first diagnosis was a probable rejection of the sutures that were not absorbed, but based on the clinical signs, reported history, complementary laboratory tests and no response to treatment with the conventional antibiotic therapy (cephalosporins/quinolones) prescribed, the ultimate diagnosis was a mycobacteriosis caused by Micobacterium fortuitum. Read More

View Article and Full-Text PDF

General characteristics, features of cultivation and antibiotic resistance representatives of mycobacterium fortuitum group representatives (review of literature).

Klin Lab Diagn 2021 Apr;66(4):223-228

Samara State Medical University.

Recently, more and more scientific works have been devoted to non-tuberculous mycobacteria, both by domestic and foreign researchers. One of the main reasons for this is the increase in patients with immunosuppression of various origins, improvement of the quality of laboratory and instrumental diagnostics of mycobacteriosis. This article focuses on the representatives of the M. Read More

View Article and Full-Text PDF

Sulfonamides complexed with metals as mycobacterial biofilms inhibitors.

J Clin Tuberc Other Mycobact Dis 2021 May 17;23:100217. Epub 2021 Jan 17.

Programa de Pós-graduação em Ciências Farmacêuticas, Universidade Federal de Santa Maria, 1000 Avenida Roraima, 97105900 Santa Maria, RS, Brazil.

Rapidly growing mycobacteria (RGM) are found in non-sterile water and often associated with severe post-surgical infections and affect immunocompromised patients. In addition, RGM can prevent the host's immune response and have the ability to adhere to and form biofilms on biological and synthetic substrates, making pharmacological treatment difficult because conventional antimicrobials are ineffective against biofilms. Thus, there is an urgent need for new antimicrobial compounds that can overcome these problems. Read More

View Article and Full-Text PDF

Mycobacteria In Skin Lesions and the Habitat of the Endangered Houston Toad (Anaxyrus houstonensis).

J Wildl Dis 2021 Apr 15. Epub 2021 Apr 15.

Texas State University, Department of Biology, 601 University Drive, San Marcos, Texas 78666, USA.

Head-starting of the federally endangered Houston toad (Anaxyrus houstonensis), that is, the release of egg strands, tadpoles, and metamorphic juveniles produced in captivity into the original breeding ponds, requires assessment of potential threats for the transmission of pathogens from captive to free-ranging toads. We used Illumina-based 16S rRNA V3 amplicon sequencing to investigate the community structure of bacteria from skin lesions of captive Houston toad and habitat (pond) samples. Proteobacteria, alone or together with Actinobacteria and, in some samples, Cyanobacteria represented virtually all reads in tissue lesion samples, whereas pond samples were much more diverse, with Acidobacteria, Actinobacteria, Bacteriodetes, Chloroflexi, Cyanobacteria, Firmicutes, Planctomycetes, Proteobacteria, and Verrucomicrobia present with little variation between samples. Read More

View Article and Full-Text PDF

Mycobacterium fortuitum and Mycobacterium abscessus infections in the foot and ankle in two immunocompetent patients.

Biomedicine (Taipei) 2020 1;10(4):52-56. Epub 2020 Dec 1.

Department of Orthopaedic Surgery, Khoo Teck Puat Hospital, Singapore.

Nontuberculous mycobacteria (NTM) infections of the musculoskeletal system are commonly missed due to its rarity and the absence of systemic symptoms. A high clinical index of suspicion is required to recognize such infections as they may occur in immunocompetent hosts. We present two cases of foot and ankle NTM infections involving and in two such patients. Read More

View Article and Full-Text PDF
December 2020

Comparison of Susceptibility of Delafloxacin with Ciprofloxacin, Moxifloxacin, and Other Comparator Antimicrobials against Isolates of Nontuberculous Mycobacteria.

Antimicrob Agents Chemother 2021 Jun 17;65(7):e0007921. Epub 2021 Jun 17.

The University of Texas Health Science Center at Tyler, Mycobacteria/Nocardia Laboratory, Tyler, Texas, USA.

Nontuberculous mycobacterial (NTM) infections are increasing globally. Mycobacterium avium complex (MAC) and M. abscessus complex are the most commonly reported NTM. Read More

View Article and Full-Text PDF

Mycobacterium fortuitum infection from needlefish impalement during diving: A diagnostic challenge.

Travel Med Infect Dis 2021 May-Jun;41:102056. Epub 2021 Apr 5.

Division of Infectious Diseases, Department of Internal Medicine, Taichung Veterans General Hospital, Taichung, Taiwan; Rong Hsing Research Center for Translational Medicine, National Chung Hsing University, Taichung, Taiwan; Ph.D. Program in Translational Medicine, National Chung Hsing University, Taichung, Taiwan. Electronic address:

View Article and Full-Text PDF

Mycobacterial periprosthetic joint infection after primary total knee arthroplasty.

Int Orthop 2021 Apr 8. Epub 2021 Apr 8.

Department of Orthopaedic Surgery, Yonsei University College of Medicine, Seoul, Republic of Korea.

Purpose: Mycobacterial periprosthetic joint infection (PJI) is very rare and is generally associated with an immunosuppressive environment. Few large-scale studies of this unusual PJI have been conducted. The current study was performed to assess the clinical features and outcomes following two-stage re-implantation for mycobacterial PJI after primary total knee arthroplasty (TKA). Read More

View Article and Full-Text PDF

Rare enough ? Cardiac Device-related pocket Infection due to .

Clin Case Rep 2021 Mar 26;9(3):1566-1570. Epub 2021 Jan 26.

Assistant Professor of Medicine Department of Hospital Medicine Penn State Health Milton S. Hershey Medical Center Hershey Pennsylvania USA.

Nontuberculous mycobacteria are rare causes of cardiac implantable electronic device (CIED)-related infections and may lead to device-related endocarditis, so preventing them is key. We present a case of CIED-related pocket infection due to Mycobacterium fortuitum which highlights the challenges in management of such infections. Read More

View Article and Full-Text PDF

Molecular epidemiology of Mycobacterium tuberculosis complex in the Volta Region of Ghana.

PLoS One 2021 17;16(3):e0238898. Epub 2021 Mar 17.

Bacteriology Department, Noguchi Memorial Institute for Medical Research (NMIMR), University of Ghana, Accra, Ghana.

Context: Available molecular epidemiological data from recent studies suggest significant genetic variation between the different lineages of Mycobacterium tuberculosis complex (MTBC) and the MTBC lineages might have adapted to different human populations.

Aim: This study sought to determine the population structure of clinical MTBC isolates from the Volta Region of Ghana.

Methods: The MTBC isolates obtained from collected sputum samples were identified by PCR detecting of IS6110 and genotyped using spoligotyping. Read More

View Article and Full-Text PDF

Biofilm formation in the lung contributes to virulence and drug tolerance of Mycobacterium tuberculosis.

Nat Commun 2021 03 11;12(1):1606. Epub 2021 Mar 11.

Council of Scientific and Industrial Research, Institute of Microbial Technology, Chandigarh, India.

Tuberculosis is a chronic disease that displays several features commonly associated with biofilm-associated infections: immune system evasion, antibiotic treatment failures, and recurrence of infection. However, although Mycobacterium tuberculosis (Mtb) can form cellulose-containing biofilms in vitro, it remains unclear whether biofilms are formed during infection in vivo. Here, we demonstrate the formation of Mtb biofilms in animal models of infection and in patients, and that biofilm formation can contribute to drug tolerance. Read More

View Article and Full-Text PDF

Epidemiological risk factors and the geographical distribution of eight Mycobacterium species.

Authors:
Maura J Donohue

BMC Infect Dis 2021 Mar 12;21(1):258. Epub 2021 Mar 12.

United States Environmental Protection Agency, Office of Research and Development, Center of Environmental Solutions and Emergency Response (CESER), 26 W. Martin Luther King Dr. Mail Stop 587, Cincinnati, OH, 45268, USA.

Background: Nontuberculous mycobacteria (NTM) are environmental bacterium that may cause and/or compound respiratory diseases in humans. There are over a hundred NTM species with varying pathogenicity's Therefore, it is necessary to characterize the populations at risk for each species.

Methods: Demographic (age, sex, and state of residence) and microbiological data from 2014 were extracted from Mississippi, Missouri, and Ohio disease surveillance systems. Read More

View Article and Full-Text PDF

Rapid identification of non-tuberculous mycobacteria with MALDI-TOF mass spectrometry.

Infez Med 2021 Mar;29(1):79-84

Microbiology Unit, ASST Papa Giovanni XXIII, Bergamo, Italy.

Rapid and accurate identification of non-tuberculous mycobacteria (NTM) is important for a prompt start to antibiotic therapy. The aim of this study was to obtain accurate identification of NTM quickly by analyzing the performance of the MALDI-TOF mass spectrometry (MS) system VITEK® MS in identifying various NTM species from solid medium and MGIT 960 liquid medium. The study was performed in two phases: preliminary and perspective. Read More

View Article and Full-Text PDF

Bipolar Distribution of Minimum Inhibitory Concentration of Q203 Across Mycobacterial Species.

Microb Drug Resist 2021 Feb 26. Epub 2021 Feb 26.

Department of Bacteriology and Immunology, Beijing Key Laboratory on Drug-Resistant Tuberculosis Research, Beijing Chest Hospital, Capital Medical University, Beijing Tuberculosis and Thoracic Tumor Institute, Beijing, China.

In this study, we conducted an experimental study to evaluate susceptibility of Q203 against , as well as the major pathogenic nontuberculous mycobacterial species. A total of 344 nonduplicate mycobacterium isolates were randomly selected for susceptibility testing. Overall, Q203 exhibited excellent activity against multidrug-resistant (MDR-) and extensively drug-resistant tuberculosis (XDR-TB) isolates, whereas it showed high minimum inhibitory concentration (MIC) values for all nontuberculous mycobacteria (NTM) isolates tested. Read More

View Article and Full-Text PDF
February 2021

Genitourinary non-tuberculous mycobacterial (GU-NTM) infections: A single institution experience in South India.

Indian J Tuberc 2021 Jan 26;68(1):65-72. Epub 2020 Aug 26.

Former Senior Resident, Department of Urology, Amrita Institute of Medical Sciences and Research Centre, Amrita Vishwa Vidyapeetham (Amrita University), Ponekkara, Cochin, Kerala, 682041, India.

Introduction: Non-tuberculous mycobacterial (NTM) infections are rarely reported, and more so with genitourinary infections. This retrospective study was designed to understand the proportion and behaviour of genitourinary non-tuberculous mycobacterial (GU-NTM) infections compared with genitourinary mycobacterial tuberculosis (GU-MTB) treated at a tertiary care hospital in South India.

Materials And Methods: The hospital records of every bacteriologically proved GU-MTB and GU-NTM infections treated at this centre from 2010 to 2016 were retrospectively reviewed. Read More

View Article and Full-Text PDF
January 2021

Prevalence and speciation of non-tuberculous mycobacteria among pulmonary and extrapulmonary tuberculosis suspects in South India.

J Infect Public Health 2021 Mar 19;14(3):320-323. Epub 2021 Feb 19.

Department of Microbiology, Jawaharlal Institute of Postgraduate Medical Education and Research (JIPMER), Pondicherry, India. Electronic address:

Background And Objectives: Non tuberculous mycobacteria (NTM) is an emerging opportunistic pathogen increasing globally and indistinguishable from tuberculosis (TB), which remains a challenge particularly in developing countries. This study aimed to identify the prevalence and diversity of NTM among both pulmonary TB (PTB) and extrpulmonary TB (EPTB) clinical isolates from south India.

Methodology: A total of 7633 specimens from TB suspects (PTB, n = 4327 and EPTB, n = 3306) were collected during the study period (July 2018-March 2020) in a tertiary care hospital. Read More

View Article and Full-Text PDF

Species diversity and molecular analysis of opportunistic Mycobacterium, Nocardia and Rhodococcus isolated from the hospital environment in a developing country, a potential resources for nosocomial infection.

Genes Environ 2021 Jan 28;43(1). Epub 2021 Jan 28.

Department of Basic and Laboratory and Sciences, Khomein University of Medical Sciences, Qods street, Khomein, Iran.

Background: Hospital environmental resources have a significant role in cross-transmission of opportunistic pathogens such as actinomycetes species to the patients. Actinomycetes have a remarkable capability to survive in adverse and harsh conditions of hospital environments; therefore, they are a threat to the health of patients. Due to this issue, we aimed to determine the frequency and diversity of actinomycetes species in hospital soil, water and dust by using a combination of conventional and molecular methods including the phenotypic and biochemical tests for preliminary identification and the PCR amplification of the specific region of the 16S rRNA, hsp65 gene and sequence analyses of 16S rRNA for the genus and species identification. Read More

View Article and Full-Text PDF
January 2021

The Epidemiology of first and second-line drug-resistance Mycobacterium tuberculosis complex common species: Evidence from selected TB treatment initiating centers in Ethiopia.

PLoS One 2021 28;16(1):e0245687. Epub 2021 Jan 28.

Ethiopian Public Health Institute, Addis Ababa, Ethiopia.

Background: Drug-resistance in Mycobacterium tuberculosis complex remains a major health burden in human history and still is a major leading cause of death in developing countries including Ethiopia. Early detection of all forms of drug-resistant Tuberculosis(TB) is a key factor to reduce and contain the spread of these resistant strains.

Methods: A health facility-based cross-sectional study was employed, based on demographic, clinical, and laboratory data collected from 204 patients with bacteriological confirmed TB. Read More

View Article and Full-Text PDF

Species identification and antimicrobial susceptibility testing of non-tuberculous mycobacteria isolated in Chongqing, Southwest China.

Epidemiol Infect 2020 12 28;149:e7. Epub 2020 Dec 28.

Faculty of Medical Technology, Chongqing Medical and Pharmaceutical College, Chongqing401331, China.

With the rapid rise in the prevalence of non-tuberculous mycobacteria (NTM) diseases across the world, the microbiological diagnosis of NTM isolates is becoming increasingly important for the diagnosis and treatment of NTM disease. In this study, the clinical presentation, species distribution and drug susceptibility of patients with NTM disease visiting the Chongqing Public Health Medical Centre during March 2016-April 2019 were retrospectively analysed. Among the 146 patients with NTM disease, eight NTM species (complex) were identified. Read More

View Article and Full-Text PDF
December 2020

Phytochemical characterization, genotoxicity, cytotoxicity, and antimicrobial activity of essential oil.

Nat Prod Res 2020 Dec 28:1-5. Epub 2020 Dec 28.

Laboratory of Oral Microbiology Research (LAPEMICRO), Federal University of Santa Maria, Santa Maria, RS, Brazil.

This study investigated the chemical constituents of essential oil and is the first to relate cytogenotoxicity with oxidative metabolism and antimicrobial activity. Chromatographic analysis of the essential oil showed methyl salicylate (99.96%) and linalool (0. Read More

View Article and Full-Text PDF
December 2020

Occurrence of spp. in ornamental fish.

Ann Agric Environ Med 2020 Dec 9;27(4):535-539. Epub 2019 Dec 9.

Department of Fish Diseases and Biology, Faculty of Veterinary Medicine, University of Life Sciences, Lublin, Poland.

Introduction And Objective: Fish mycobacteriosis is a chronic granulomatous disease caused by several species of bacteria from the genus , described as nontuberculous mycobacteria (NTM). The most important species causing fish mycobacterioses are , and . Mycobacteria infecting fish also include zoonotic pathogens. Read More

View Article and Full-Text PDF
December 2020

Use of Negative-Pressure Wound Therapy With Instillation and Dwell in Breast Reconstruction.

Plast Reconstr Surg 2021 01;147(1S-1):34S-42S

From the Division of Plastic Surgery, Humber River Hospital.

Summary: The use of negative-pressure wound therapy (NPWT) has expanded over the last 3 decades, paralleled and documented by an increase in research. This article discusses the evolution and current applications of NPWT in modern breast reconstruction. Negative-pressure wound therapy with instillation and dwell (NPWTi-d) technology can be used to remove infectious material, facilitate salvaging compromised tissue, and stabilize the soft-tissue environment. Read More

View Article and Full-Text PDF
January 2021

Feline mycobacterial disease in northern California: Epidemiology, clinical features, and antimicrobial susceptibility.

J Vet Intern Med 2021 Jan 21;35(1):273-283. Epub 2020 Dec 21.

Veterinary Medical Teaching Hospital, School of Veterinary Medicine, University of California, Davis, Davis, California, USA.

Background: Mycobacterial infections in cats are challenging to treat and incompletely described.

Hypothesis/objectives: To describe the features of mycobacterial infections in cats from northern California.

Animals: Nineteen cats, all with nontuberculous mycobacterial (NTM) infections; 4 with Mycobacterium avium infection, 15 with rapid-growing mycobacterial (RGM) infection. Read More

View Article and Full-Text PDF
January 2021

Hospital ice, ice machines, and water as sources of nontuberculous mycobacteria: Description of qualitative risk assessment models to determine host-Nontuberculous mycobacteria interplay.

Int J Mycobacteriol 2020 Oct-Dec;9(4):347-362

Laboratory for Disinfection and Pathogen Elimination Studies, Northern Ireland Public Health Laboratory, Nightingale (Belfast City) Hospital, Belfast, Northern Ireland, UK.

Over the last 30 years, there have been at least 17 published reports of nontuberculous mycobacteria (NTMs) being isolated from hospital ice or ice-making machines. Of these, 12 were reports of pseudo-outbreaks, i.e. Read More

View Article and Full-Text PDF
December 2020