2,245 results match your criteria Mycobacterium Fortuitum

Non-tuberculous mycobacteria, not , are a significant cause of TB-like lesions observed in slaughtered cattle in Ghana.

IJID Reg 2022 Jun 11;3:8-14. Epub 2022 Feb 11.

Department of Bacteriology, Noguchi Memorial Institute for Medical Research, College of Health Sciences, University of Ghana, Legon, Accra, Ghana.

Objectives: The aim was to isolate and identify the species of mycobacteria causing tuberculous-like (TB-like) lesions in cattle in Ghana.

Methods: Between 2019 and 2020, 68 bovine tissue samples with TB-like lesions, identified during post slaughter examination, were obtained from four major abattoirs close to border towns in Ghana. The samples were cultured on Lowenstein-Jensen medium. Read More

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Prevalence of non-tuberculous mycobacteria among previously treated TB patients in the Gulf of Guinea, Africa.

IJID Reg 2022 Jun 14;3:287-292. Epub 2022 May 14.

Department of Medical Laboratory Science, College of Medicine, University of Calabar, Calabar, Nigeria.

Objective: Differentiation between non-tuberculous mycobacteria NTM) and Mycobacterium tuberculosis complex (MTBC) is crucial for case management with the appropriate antimycobacterials. This study was undertaken in three West and Central African countries to understand NTM associated with pulmonary tuberculosis in the sub-region.

Methods: A collection of 503 isolates (158 from Cameroon, 202 from Nigeria and 143 from Ghana) obtained from solid and liquid cultures were analysed. Read More

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Mycobacterium fortuitum fabG4 knockdown studies: Implication as pellicle and biofilm specific drug target.

J Basic Microbiol 2022 Jun 23. Epub 2022 Jun 23.

Department of Biotechnology and Bioinformatics, Jaypee University of Information Technology, Waknaghat, Solan, Himachal Pradesh, India.

The fatty acid biosynthesis pathway is crucial for the formation of the mycobacterial cell envelope. The fatty acid synthase type-II (FAS-II) components are attractive targets for designing anti-biofilm inhibitors. Literature review, bioinformatics analysis, cloning, and sequencing led to the identification of a novel Mycobacterium fortuitum FAS-II gene MFfabG4 which interacts with mycobacterial proteins involved in biofilm formation. Read More

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activity of fidaxomicin against nontuberculosis mycobacteria.

J Med Microbiol 2022 Jun;71(6)

College of Veterinary Medicine, China Agricultural University, Beijing, PR China.

Nontuberculous mycobacteria (NTM) infections are increasing worldwide and are relatively resistant to many of the first- and second-line drugs to treat tuberculosis. Macrolide antibiotics, such as clarithromycin and azithromycin, are the key drugs for treating NTM infections. Fidaxomicin is a macrolide antibiotic that is widely used in treating infections, and has high activity against especially multidrug-resistant tuberculosis (MDR-TB) and has no cross-resistance with rifampicin. Read More

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Isolation of potential zoonotic Mycobacterium spp. from diseased freshwater angelfish (Pterophyllum scalare) from an aquarium.

Braz J Biol 2022 6;84:e262851. Epub 2022 Jun 6.

Universidade de São Paulo, Departamento de Medicina Veterinária Preventiva e Saúde Animal, São Paulo, SP, Brasil.

Nontuberculous mycobacteria infection is one of the most common chronic bacterial diseases in ornamental aquarium fish and appears to be directly related to stressful husbandry practices. Furthermore, it also represents zoonotic potential. Here we present the isolation and characterization of non-tuberculous mycobacteria from diseased freshwater angelfish (Pterophyllum scalare) in São Paulo, Brazil. Read More

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Post Surgical Non-tuberculous Mycobacterium: A Case Series.

Cureus 2022 May 3;14(5):e24701. Epub 2022 May 3.

Department of Medicine, Government Medical College, Aurangabad, IND.

Background There has been an increase in non-tuberculous mycobacteria (NTM) infection reports in humans. Surgeons are concerned about the link between them and surgical site infections. As a result, it has been challenging to determine just how common this illness is. Read More

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Anti-programmed death 1 antibody in the treatment of coexistent and lung cancer: A case report.

World J Clin Cases 2022 Apr;10(12):3801-3807

Department of Thoracic Oncology, Tianjin Medical University Cancer Institute and Hospital, Tianjin 300060, China.

Background: Nontuberculous mycobacterium (NTM) refers to all mycobacteria except and , also known as environmental Mycobacterium. The patients with lung cancer and NTM are somewhat special; the two diseases are inevitably influenced by each other. It brings difficulties and challenges to the choice of treatment. Read More

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Prosthetic joint infection of the hip and knee due to : A systematic review.

World J Orthop 2022 May 18;13(5):503-514. Epub 2022 May 18.

Nicolaas Institute of Constructive Orthopaedic Research and Education Foundation at Medistra Hospital, Jakarta 12950, Indonesia.

Background: () is an emerging cause of hip and knee prosthetic joint infection (PJI), and different species of this organism may be responsible for the same.

Aim: To evaluate the profile of hip and knee PJI cases as published in the past 30 years.

Methods: A literature search was performed in PubMed using the MeSH terms "Prosthesis joint infection" AND "Mycobacterium" for studies with publication dates from January 1, 1990, to May 30, 2021. Read More

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Identification of nontuberculous mycobacteria isolated from household showerheads of patients with nontuberculous mycobacteria.

Sci Rep 2022 May 23;12(1):8648. Epub 2022 May 23.

Division of Pulmonary and Critical Care Medicine, Department of Internal Medicine, Severance Hospital, Yonsei University College of Medicine, 50-1 Yonsei-ro, Seodaemun-gu, Seoul, 03722, Republic of Korea.

This study aimed to examine whether nontuberculous mycobacteria (NTM) inside household showerheads are identical to those in patients with NTM-pulmonary disease (PD) since household water is one of the potential NTM sources. Samples were obtained from 32 household showerheads of patients with NTM-PD recruited through the Pulmonary Outpatient Department at the Severance Hospital between October 2018 and October 2019. All isolates from patients with NTM-PD were diagnosed using a reverse-hybridization line probe assay based on the ropB gene. Read More

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Antibiotic Susceptibility of Mycobacteria Isolated from Ornamental Fish.

J Vet Res 2022 Mar 25;66(1):69-76. Epub 2022 Mar 25.

Department of Biology and Fish Diseases, Faculty of Veterinary Medicine, University of Life Sciences, Lublin, Poland.

Introduction: Nontuberculous mycobacteria (NTM) are increasingly recognised as causative agents of opportunistic infections in humans for which effective treatment is challenging. There is very little information on the prevalence of NTM drug resistance in Poland. This study was aimed to evaluate the susceptibility to antibiotics of NTM, originally isolated from diseased ornamental fish. Read More

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Metagenomic exploration of antibiotic resistance genes and their hosts in aquaculture waters of the semi-closed Dongshan Bay (China).

Sci Total Environ 2022 Sep 9;838(Pt 1):155784. Epub 2022 May 9.

Key Laboratory of Marine Biogenetic Resources, Third Institute of Oceanography, Ministry of Natural Resources, Xiamen 361005, China; School of Marine Sciences, Nanjing University of Information Science and Technology, Nanjing 210044, China; Co-Innovation Center of Jiangsu Marine Bio-industry Technology, Jiangsu Ocean University, Lianyungang 222005, China. Electronic address:

In marine environments, increasing occurrence and numbers of microbial Antibiotic Resistance Gene (ARG) subtypes, especially of new beta-lactamases, have received lots of attention in recent years. Updated databases with novel developed tools provide new opportunities to obtain more comprehensive ARG profiles as well as ARG-carrying hosts. Yet, ARGs in human-associated marine aquaculture environments, e. Read More

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September 2022

A mycobacterium fortuitum infection in chronic mucocutaneous candidiasis.

Pediatr Int 2022 01;64(1):e15166

Division of Immunology, National Center for Child Health and Development, Tokyo, Japan.

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January 2022

Antibiotic delivery evaluation against Mycobacterium fortuitum using nanofluids containing carbon nanotubes.

BMC Microbiol 2022 04 11;22(1):96. Epub 2022 Apr 11.

Department of Mycobacteriology and Pulmonary Research, Pasteur Institute of Iran, Tehran, Iran.

Background: Mycobacterium fortuitum (M. fortuitum) is a bacterium, which can cause infections in many anatomical regions of the body, including the skin, lymph nodes, and joints. This bacterium, which belongs to a group of bacteria known as nontuberculous mycobacteria, is regarded as an important nosocomial pathogen worldwide owing to its increasing antibiotic resistance. Read More

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Complete Genome Sequence of Mycobacterium fortuitum subsp. JCM 6387, a Type Strain of Human-Pathogenic Mycobacteria Showing Inducible Macrolide Resistance.

Microbiol Resour Announc 2022 Apr 31;11(4):e0006022. Epub 2022 Mar 31.

Department of Mycobacteriology, Leprosy Research Center, National Institute of Infectious Diseases, Tokyo, Japan.

Mycobacterium fortuitum subsp. is a rapidly growing mycobacterial species for which pathogenic features are unclear. Here, we report the complete genome sequence of the Mycobacterium fortuitum subsp. Read More

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infection after fracture repair of the tibia and fibula.

IDCases 2022 7;28:e01468. Epub 2022 Mar 7.

Department of Infectious Diseases, National Hospital Organization Kyoto Medical Center, Kyoto, Japan.

is the causative agent of bovine farcy. shares common properties with rapidly growing mycobacteria, and distinguishing between and is reportedly complex and challenging. Moreover, few studies have isolated from human clinical samples. Read More

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Heterogeneity of the Tissue-specific Mucosal Microbiome of Normal Grass Carp (Ctenopharyngodon idella).

Mar Biotechnol (NY) 2022 Apr 18;24(2):366-379. Epub 2022 Mar 18.

Key Laboratory of Freshwater Aquatic Genetic Resources, Ministry of Agriculture and Rural Affairs, Shanghai Ocean University, Shanghai, 201306, China.

Microbiome plays key roles in the digestion, metabolism, and immunity of the grass carp (Ctenopharyngodon idella). Here, we characterized the normal microbiome of the intestinal contents (IC), skin mucus (SM), oral mucosa (OM), and gill mucosa (GM) of the grass carp, as well as the microbiome of the sidewall (SW) of the raising pool, using full-length 16S rRNA sequencing based on the PacBio platform in this specie for the first time. Twenty phyla, 38 classes, 130 families, 219 genera, and 291 species were classified. Read More

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Distribution of nontuberculous mycobacteria in patients with and without HIV/AIDS in Chongqing.

HIV Med 2022 03;23 Suppl 1:54-63

Guangzhou Eighth People's Hospital, Guangzhou Medical University, Guangzhou, China.

Introduction: In this study, the distribution of nontuberculous mycobacteria (NTM) strains in patients with and without HIV/AIDS in Chongqing, China was evaluated.

Methods: A retrospective study was performed in January-December 2020 at Chongqing Public Health Medical Center. NTM strains were assessed by a multi locus phylogenetic analysis. Read More

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Nontuberculous Mycobacteria in Portugal: Trends from the last decade.

Pulmonology 2022 Feb 23. Epub 2022 Feb 23.

National Reference Laboratory for Mycobacteria, Dept of Infectious Diseases, National Institute of Health, Lisbon, Portugal. Electronic address:

Introduction And Objectives: Nontuberculous mycobacteria (NTM) are opportunistic human pathogens found in the environment. The transmission seems to be associated with inhalation of aerosol droplets, ingestion or trauma events. Recent studies indicate that NTM disease is increasing worldwide, however, the true clinical impact of NTM infections is difficult to determine due to challenges in discriminating between disease and colonization as they are ubiquitous in the environment. Read More

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February 2022

Quantifying Circulating IgY Antibody Responses against Select Opportunistic Bacterial Pathogens and Correlations with Body Condition Factors in Wild American Alligators, .

Biology (Basel) 2022 Feb 9;11(2). Epub 2022 Feb 9.

Department of Biological Sciences, Clemson University, Clemson, SC 29634, USA.

Little is known about the disease ecology of American alligators (), and especially how they respond immunologically to emerging infectious diseases and zoonotic pathogens. In this study, we examined serum samples collected from wild alligators in Florida (2010-2011) and South Carolina (2011-2012, 2014-2017) for antibody responses to multiple bacteria. Immunoglobulin Y (IgY) was purified from serum to generate a mouse monoclonal antibody (mAb AMY-9) specific to the IgY heavy chain. Read More

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February 2022

Nanomolar effective report of tetra-cationic silver(II) porphyrins against non-tuberculous mycobacteria in antimicrobial photodynamic approaches.

Photodiagnosis Photodyn Ther 2022 Jun 18;38:102770. Epub 2022 Feb 18.

Laboratory of Bioinorganic and Porphyrinic Materials, Universidade Federal de Santa Maria, Av. Roraima 1000, Campus Camobi, 97105-900, Santa Maria RS, Brazil. Electronic address:

We report the photoinactivation evaluation of Ag(II) porphyrins (cationic AgTMeP and anionic AgTPPS) in the antimicrobial photodynamic therapy (aPDT) of rapidly growing mycobacterial strains. The aPDT assays in the Mycolicibacterium fortuitum, Mycobacteroides abscessus subs. abscessus, Mycobacteroides abscessus subsp. Read More

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Epidemiological profile and follow-up of patients with pulmonary disease by non-tuberculous mycobacteria in Baixada Santista area, São Paulo.

Einstein (Sao Paulo) 2022 14;20:eAO5510. Epub 2022 Feb 14.

Instituto Adolfo Lutz, Santos, SP, Brazil.

Objective: To present the frequency and species diversity of non-tuberculous mycobacteria, estimate the prevalence of non-tuberculous mycobacterial pulmonary disease, describe the epidemiological profile, and determine the follow-up of patients with non-tuberculous mycobacterial pulmonary disease living in a region with a high burden of tuberculosis.

Methods: This a retrospective cohort observational study using data records obtained from the Instituto Adolfo Lutz - Santos and from the São Paulo Sistema de Vigilância de Tuberculose do Estado de São Paulo in the period between 2000 and 2009. The studied variables were: socio-demographic characteristics, current and past history of tuberculosis, aspects related to diagnosis, and treatment and associated diseases. Read More

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February 2022

Consensus management recommendations for less common non-tuberculous mycobacterial pulmonary diseases.

Lancet Infect Dis 2022 Jul 25;22(7):e178-e190. Epub 2022 Jan 25.

National Jewish Health and University of Colorado Health Sciences, Denver, CO, USA.

The 2020 clinical practice guideline for the treatment of non-tuberculous mycobacterial pulmonary disease (NTM-PD) by the American Thoracic Society, European Respiratory Society, European Society of Clinical Microbiology and Infectious Diseases, and Infectious Diseases Society of America; and the 2017 management guideline by the British Thoracic Society covered pulmonary diseases in adults caused by Mycobacterium avium complex, Mycobacterium kansasii, Mycobacterium xenopi, and Mycobacterium abscessus. In order to provide evidence-based recommendations for the treatment of less common non-tuberculous mycobacterial (NTM) species in adult patients without cystic fibrosis or HIV infection, our expert panel group performed systematic literature searches to provide management guidance for pulmonary diseases caused by seven additional organisms: Mycobacterium chelonae, Mycobacterium fortuitum, Mycobacterium genavense, Mycobacterium gordonae, Mycobacterium malmoense, Mycobacterium simiae, and Mycobacterium szulgai. Treatment recommendations were developed by a structured consensus process. Read More

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Potential of the Acetone Leaf Extract and Fractions of (Eckl.) Vatke (Rubiaceae) to Combat Co-Infection of Tuberculosis and Helminthiasis.

Front Pharmacol 2021 11;12:744137. Epub 2022 Jan 11.

Phytomedicine Programme, Department of Paraclinical Sciences, Faculty of Veterinary Science, University of Pretoria, Pretoria, South Africa.

Tuberculosis (TB) is a disease of global importance that affects millions of people. Approximately a quarter of the world's population is currently infected with , and about 10% of those infected will develop into active disease, particularly immune compromised individuals. Helminthiasis is of global health importance, affecting over 2 billion people mostly in resource-poor countries. Read More

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January 2022

From a Machine Saw to a Case of Pyomyositis.

J Investig Med High Impact Case Rep 2022 Jan-Dec;10:23247096211069766

Kern Medical, Bakersfield, CA, USA.

Pyomyositis is a bacterial infection occurring mainly in skeletal muscles. It is most commonly caused by with initial symptoms including muscle pain, swelling, and site tenderness. When available, the most accurate technique to determine the extent and the specific location of disease is the magnetic resonance imaging. Read More

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January 2022

Anaerobes and methanogens dominate the microbial communities in water harvesting ponds used by Kenyan rural smallholder farmers.

Sci Total Environ 2022 May 10;819:153040. Epub 2022 Jan 10.

School of Life Sciences, University of Essex, Wivenhoe Park, Colchester CO4 3SQ, UK. Electronic address:

Many rural smallholder farmers in Kenya use water-harvesting ponds, to collect rainwater, as sustainable sources of water for domestic and agricultural purposes. There is currently limited information regarding the microbial ecology in these ponds. Here, we used High Throughput Sequencing (HTS) to characterize the microorganisms present (including potential pathogens and indicator species) alongside ion chromatography to measure water chemistry (anion and cation concentration). Read More

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mtROS Induced TLR-2-SOCE Signaling Plays Proapoptotic and Bactericidal Role in -Infected Head Kidney Macrophages of .

Front Immunol 2021 20;12:748758. Epub 2021 Dec 20.

Immunobiology Laboratory, Department of Zoology, University of Delhi, Delhi, India.

The mechanisms underlying -induced mycobacteriosis remain unexplored. Using head kidney macrophages (HKM) from catfish (), we report that Ca surge across mitochondrial-Ca uniporter (MICU), and consequent mitochondrial ROS (mtROS) production, is imperative for mycobactericidal activity. Inhibition of mtROS alleviated HKM apoptosis and enhanced bacterial survival. Read More

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February 2022

Non-tuberculous Mycobacterial Infection of the Musculoskeletal System Detected at Two Tertiary Medical Centres in Henan, China, 2016-2020.

Front Microbiol 2021 16;12:791918. Epub 2021 Dec 16.

Luoyang Orthopedic Hospital of Henan Province, Orthopedic Hospital of Henan Province, Zhengzhou, China.

Non-tuberculous mycobacterial (NTM) infection of the musculoskeletal system is rare but poses a grave threat to public health. These infections yield non-specific symptoms that remain undetected until the development of the later stages of the disease. In this study, we performed a retrospective review of 25 cases of musculoskeletal NTM infection at two tertiary medical centres over a 5-year period to determine the clinical features and improve the current clinical diagnosis and treatment. Read More

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December 2021

Nontuberculous Mycobacteria Prevalence in Aerosol and Spiders' Webs in Karst Caves: Low Risk for Speleotherapy.

Microorganisms 2021 Dec 13;9(12). Epub 2021 Dec 13.

Faculty of Regional Development and International Studies, Mendel University in Brno, Tr. Generala Piky 7, 613 00 Brno, Czech Republic.

A total of 152 aerosol and spider web samples were collected: 96 spider's webs in karst areas in 4 European countries (Czech Republic, France, Italy, and Slovakia), specifically from the surface environment ( = 44), photic zones of caves ( = 26), and inside (aphotic zones) of caves ( = 26), 56 Particulate Matter (PM) samples from the Cave System (speleotherapy facility; = 21) and from aerosol collected from the nearby city of ( = 35) in the Czech Republic. Nontuberculous mycobacteria (NTM) were isolated from 13 (13.5%) spider's webs: 5 isolates of saprophytic NTM (, , , and complex) and 6 isolates of potentially pathogenic NTM ( ssp. Read More

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December 2021

Development of a nucleic acid chromatography assay for the detection of commonly isolated rapidly growing mycobacteria.

J Med Microbiol 2021 Dec;70(12)

Department of Mycobacterium Reference and Research, Research Institute of Tuberculosis, Japan Anti-Tuberculosis Association (JATA), 3-1-24 Matsuyama, Kiyose, Tokyo 204-8533, Japan.

Non-tuberculosis mycobacterium infections are increasing worldwide, including those caused by rapidly growing mycobacteria (RGM). The identification of the aetiological agent in the context of infections is essential for the adoption of an adequate therapeutic approach. However, the methods for the rapid distinction of different RGM species are less than optimal. Read More

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December 2021