2,044 results match your criteria Mycobacterium Fortuitum


Outbreak of Nontuberculous Mycobacteria Joint Prosthesis Infections, Oregon, USA, 2010-2016.

Emerg Infect Dis 2019 May;25(5):849-855

We investigated a cluster of Mycobacterium fortuitum and M. goodii prosthetic joint surgical site infections occurring during 2010-2014. Cases were defined as culture-positive nontuberculous mycobacteria surgical site infections that had occurred within 1 year of joint replacement surgery performed on or after October 1, 2010. Read More

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http://wwwnc.cdc.gov/eid/article/25/5/18-1687_article.htm
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http://dx.doi.org/10.3201/eid2505.181687DOI Listing
May 2019
1 Read

as a cause of acute CNS infection in an immune-competent girl undergoing repeated VP shunt surgeries.

BMJ Case Rep 2019 Apr 15;12(4). Epub 2019 Apr 15.

Department of Microbiology, All India Institute of Medical Sciences, New Delhi, India.

We present the case of a 14-year-old immune-competent girl with ventriculoperitoneal shunt who was repeatedly hospitalised with meningeal signs despite repeated shunt revision surgeries. Eventually was isolated and the patient improved after specific treatment. is a rapidly growing, non-tuberculous mycobacterium (NTM). Read More

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http://dx.doi.org/10.1136/bcr-2018-226900DOI Listing
April 2019
1 Read

Exogenous lipoid pneumonia in children: A systematic review.

Paediatr Respir Rev 2019 Jan 20. Epub 2019 Jan 20.

Division of Paediatric Pulmonology, Department of Paediatrics and Child Health and Medical Research Council Unit on Child and Adolescent Health, University of Cape Town, Cape Town, South Africa.

Objectives: To describe the clinical-radiological-pathological characteristics and treatment outcomes of children with suspected exogenous lipoid pneumonia (ELP).

Design: Systematic review. We searched electronic databases and reference lists published between 1967 and 2018, restricted to non-accidental cases. Read More

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https://linkinghub.elsevier.com/retrieve/pii/S15260542183013
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http://dx.doi.org/10.1016/j.prrv.2019.01.001DOI Listing
January 2019
3 Reads

Meningitis: Approach to Lumboperitoneal Shunt Infection.

South Med J 2019 Apr;112(4):217-221

From the Department of Neurosurgery, University of Illinois at Chicago, Chicago, and Department of Infectious Disease, Community Healthcare System, St Mary Medical Center, Hobart, Indiana.

is a rare, opportunistic pathogen most frequently contracted through contact with a contaminated source. An immunocompetent 26-year-old female patient presented to our institution with an infected lumboperitoneal (LP) shunt presenting as continued nonhealing wounds. After multiple debridements, shunt revisions, and wound closure failures, infectious disease specialists were consulted. Read More

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http://dx.doi.org/10.14423/SMJ.0000000000000955DOI Listing
April 2019
3 Reads

bacteremia in an immunocompetent host.

IDCases 2019 12;15:e00523. Epub 2019 Mar 12.

Infectious Diseases Consultant, Columbus Regional Hospital, Columbus, IN, United States.

Non-tuberculous mycobacteria can cause catheter associated blood stream infections. The causative agents are generally rapid growers that belong to the Mycobacterium fortuitum and Mycobacterium mucogenicum groups. A 65 year hospitalized patient with temporary central venous catheter who developed Mycobacterium smegmatis bacteremia. Read More

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https://data.crossref.org/10.1016%2Fj.idcr.2019.e00523
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http://dx.doi.org/10.1016/j.idcr.2019.e00523DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6430072PMC
March 2019
3 Reads

Species Distribution and Macrolide Susceptibility of Complex Clinical Isolates.

Antimicrob Agents Chemother 2019 Mar 18. Epub 2019 Mar 18.

Division of Pulmonary and Critical Care Medicine, Department of Medicine, Samsung Medical Center, Sungkyunkwan University School of Medicine, Seoul, South Korea

The understanding of species distribution and inducible macrolide resistance in the complex (MFC) is limited. Of 90 mostly respiratory MFC clinical isolates, half were , followed by , , , and Most , , and isolates were inducibly resistant to clarithromycin, whereas two-thirds of were clarithromycin susceptible. Clarithromycin-resistant isolates exhibited common mutations of (39), potentially involved in clarithromycin resistance. Read More

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http://dx.doi.org/10.1128/AAC.02331-18DOI Listing
March 2019
1 Read
4.476 Impact Factor

Ribosomal maturation factor (RimP) is essential for survival of nontuberculous mycobacteria under in vitro acidic stress conditions.

3 Biotech 2019 Apr 6;9(4):127. Epub 2019 Mar 6.

Department of Biotechnology and Bioinformatics, Jaypee University of Information Technology, Waknaghat, Solan, HP 173234 India.

is an important human pathogenic NTM, which resists stress conditions inside macrophages by exploitation of specific genes. TnphoA-based transposon mutagenesis was employed to identify membrane genes responsible for survival of under such stress conditions. A library of about 450 mutants was constructed after electroporation of vector pRT291 into wild-type . Read More

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http://dx.doi.org/10.1007/s13205-019-1659-yDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6403276PMC
April 2019
1 Read

Cardiac resynchronization therapy-defibrillator pocket infection caused by Mycobacterium fortuitum: a case report and review of the literature.

BMC Cardiovasc Disord 2019 Mar 5;19(1):53. Epub 2019 Mar 5.

Department of Cardiology, Huashan Hospital of Fudan University, 12 Wulumuqi Zhong Road, Shanghai, 200040, China.

Background: With the rising utilization of cardiovascular implantable electronic devices (CIEDs), infections secondary to device implantation are increasingly encountered. Staphylococcus aureus and coagulase-negative staphylococci are usually the predominant causative organisms. A CIED infection due to non-tuberculous mycobacteria (NTM) is extremely rare. Read More

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http://dx.doi.org/10.1186/s12872-019-1028-0DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6402086PMC
March 2019
2 Reads

Nontuberculous mycobacteria in cervical lymphadenopathies of HIV positive and HIV-negative adults

Rev Med Inst Mex Seguro Soc 2019 Jan 28;56(5):456-461. Epub 2019 Jan 28.

Secretaría de Salud, Hospital General de México “Dr. Eduardo Liceaga”, Unidad de Neumología y Cirugía de Tórax. Ciudad de México, México

Background: Tuberculosis is a global public health problem, especially in emerging countries. Mycobacterium tuberculosis is the main cause of cervical lymphadenopathy; nontuberculous mycobacteria are relatively common in children and rare in adults.

Objective: To identify and establish the frequency of infectious etiology by nontuberculous mycobacteria in Mexican adult patients with cervical lymphadenopathy. Read More

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January 2019
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Diversity of Nontuberculous Mycobacteria in Kuwait: Rapid Identification and Differentiation of Mycobacterium Species by Multiplex PCR, INNO-LiPA Mycobacteria v2 Assay and PCR Sequencing of rDNA.

Med Princ Pract 2019 Feb 14. Epub 2019 Feb 14.

Department of Microbiology, Faculty of Medicine, Kuwait University, Safat, Kuwait.

Objective: Nontuberculous mycobacteria (NTM) often cause disease that is clinically indistinguishable from tuberculosis. Specific identification is important as treatment varies according to Mycobacterium species causing the infection. This study used multiplex PCR (mPCR) assay for rapid differentiation of mycobacterial growth indicator tube 960 system (MGIT) cultures as Mycobacterium tuberculosis (MTB) or NTM together with INNO LiPA Mycobacteria v2 assay (LiPA) and/or PCR sequencing of rDNA for species-specific identification of selected MTB and all NTM isolates in Kuwait. Read More

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http://dx.doi.org/10.1159/000498910DOI Listing
February 2019
2 Reads

Mycobacterial Aminoglycoside Acetyltransferases: A Little of Drug Resistance, and a Lot of Other Roles.

Front Microbiol 2019 30;10:46. Epub 2019 Jan 30.

Departamento de Microbiología, Facultad de Medicina - Instituto Universitario de Investigación de Biocomputación y Física de Sistemas Complejos, Instituto de Investigación Sanitaria Aragón, Universidad de Zaragoza, Zaragoza, Spain.

Aminoglycoside acetyltransferases are important determinants of resistance to aminoglycoside antibiotics in most bacterial genera. In mycobacteria, however, aminoglycoside acetyltransferases contribute only partially to aminoglycoside susceptibility since they are related with low level resistance to these antibiotics (while high level aminoglycoside resistance is due to mutations in the ribosome). Instead, aminoglycoside acetyltransferases contribute to other bacterial functions, and this can explain its widespread presence along species of genus . Read More

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https://www.frontiersin.org/article/10.3389/fmicb.2019.00046
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http://dx.doi.org/10.3389/fmicb.2019.00046DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6363676PMC
January 2019
2 Reads

Repurposing disulfiram to target infections caused by non-tuberculous mycobacteria.

J Antimicrob Chemother 2019 Feb 7. Epub 2019 Feb 7.

Division of Microbiology, CSIR-Central Drug Research Institute, Sitapur Road, Sector 10, Janakipuram Extension, Lucknow, Uttar Pradesh, India.

Background: Non-tuberculous mycobacteria are emerging pathogens of significant worldwide interest because they have inherent drug resistance to a wide variety of FDA-approved drugs and cause a broad range of serious infections. In order to identify new drugs active against non-tuberculous mycobacteria, we identified disulfiram, utilized for treatment of alcohol dependence, as exhibiting potent growth-inhibitory activity against non-tuberculous mycobacteria.

Methods: Whole-cell growth inhibition assays were used to screen and identify novel inhibitors. Read More

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http://dx.doi.org/10.1093/jac/dkz018DOI Listing
February 2019
1 Read

Mycobacterium fortuitum infection of a hemodialysis catheter in a pediatric patient.

Hemodial Int 2019 Feb 12. Epub 2019 Feb 12.

Pediatric Nephrology division, Children's Mercy Hospital, Kansas City, Missouri, USA.

This case report discusses a pediatric patient who developed a hemodialysis catheter line infection from an uncommon etiology, Mycobacterium fortuitum. The initial presentation revealed a well appearing patient with a slow growing skin lesion near the site of the hemodialysis catheter. The treatment course was complicated by resistance to initial antibiotics leading to continued spread of the lesion. Read More

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http://dx.doi.org/10.1111/hdi.12731DOI Listing
February 2019
1 Read

Susceptibility of and Isolates to 30 Antibiotics.

Biomed Res Int 2018 30;2018:4902941. Epub 2018 Dec 30.

Department of Infectious Diseases, Huashan Hospital, Fudan University, Shanghai, China.

Objective: Nontuberculous mycobacteria (NTM) cause various diseases in humans and animals. Recently, the prevalence of NTM-related disease has been on the rise, becoming an emerging public health problem. The aim of this study was to determine the antibiotic susceptibility profiles of clinical isolates of . Read More

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http://dx.doi.org/10.1155/2018/4902941DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6330815PMC
December 2018
3 Reads

Efficacy of copper and silver as residual disinfectants in drinking water.

J Environ Sci Health A Tox Hazard Subst Environ Eng 2019 26;54(2):146-155. Epub 2019 Jan 26.

a Water and Energy Sustainable Technology Center , The University of Arizona , Tucson , Arizona , USA.

Contamination events and biofilms can decrease the amount of free chlorine available in drinking water systems. The efficacy of 100 μg/L silver and 400 μg/L copper, individually and combined, were evaluated as secondary, longer-lasting residual disinfectants against Salmonella enterica serovar Typhimurium, Escherichia coli, Listeria monocytogenes, and Mycobacterium fortuitum at 24 °C and 4 °C. A >5. Read More

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http://dx.doi.org/10.1080/10934529.2018.1535160DOI Listing
January 2019

Multicenter evaluation of the biochip assay for rapid detection of mycobacterial isolates in smear-positive specimens.

Int J Infect Dis 2019 Apr 24;81:46-51. Epub 2019 Jan 24.

State Key Laboratory for Diagnosis and Treatment of Infectious Diseases, Collaborative Innovation Center for Diagnosis and Treatment of Infectious Diseases, The First Affiliated Hospital, College of Medicine, Zhejiang University, No. 79 Qingchun Road, Shangcheng District, Hangzhou 310003, Zhejiang, China. Electronic address:

Objectives: The objective of this study was to conduct a multicentre evaluation of the performance of the biochip assay in the rapid identification of mycobacteria in smear-positive sputum specimens.

Methods: A total of 1751 sputum specimens were obtained from 7 cities in Zhejiang, China. All of the specimens were used for the discrimination of Mycobacterium species using the biochip assay, and the results were compared to the golden standard method of culture, hsp65, 16S rRNA and rpoB sequence analysis. Read More

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http://dx.doi.org/10.1016/j.ijid.2019.01.036DOI Listing
April 2019
7 Reads

[Species diversity of non-tuberculous mycobacteria isolated from aquatic environments of General Pico city, Province of La Pampa (Argentina)].

Rev Argent Microbiol 2018 Dec 19. Epub 2018 Dec 19.

Instituto Nacional de Tecnología Agropecuaria (CICVyA/INTA), Hurlingham, Buenos Aires, Argentina.

Non-tuberculous mycobacteria (NTM) are studied not only for their importance as emerging opportunistic pathogens but also for their applications in biotechnology and bioremediation. Our aim was to determine the occurrence and diversity of mycobacteria in different aquatic habitats of General Pico city, Province of La Pampa. The percentage of samples with positive cultures for mycobacteria were the following: 37. Read More

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http://dx.doi.org/10.1016/j.ram.2018.08.005DOI Listing
December 2018
1 Read

Prevalence of nontuberculous mycobacteria and high efficacy of d-cycloserine and its synergistic effect with clarithromycin against and .

Infect Drug Resist 2018 7;11:2521-2532. Epub 2018 Dec 7.

Tuberculosis Research Center, Hormozgan University of Medical Sciences, Bandar Abbas, Iran.

Background: The prevalence of pulmonary disease caused by nontuberculous mycobacteria (NTM) is reportedly on the rise in the world. Some of the species are resistant to various antibiotics; hence, limited treatment options are available. The aims of this study were to investigate the prevalence of NTM and to determine the effect of d-cycloserine against and isolated from clinical specimens to find out the synergistic effect of d-cycloserine and clarithromycin. Read More

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http://dx.doi.org/10.2147/IDR.S187554DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6290872PMC
December 2018
3 Reads

Species Typing of Nontuberculous Mycobacteria by Use of Deoxyribozyme Sensors.

Clin Chem 2019 Feb 6;65(2):333-341. Epub 2018 Dec 6.

Division of Immunity and Pathogenesis, Burnett School of Biomedical Sciences, College of Medicine, University of Central Florida, Orlando, FL;

Background: Nontuberculous mycobacteria (NTM) species are a rising threat, especially to patients living with pulmonary comorbidities. Current point-of-care diagnostics fail to adequately identify and differentiate NTM species from (). Definitive culture- and molecular-based testing can take weeks to months and requires sending samples out to specialized diagnostic laboratories. Read More

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http://dx.doi.org/10.1373/clinchem.2018.295212DOI Listing
February 2019
4 Reads

Medical Tourism and Postoperative Infections: A Systematic Literature Review of Causative Organisms and Empiric Treatment.

Plast Reconstr Surg 2018 12;142(6):1644-1651

Galveston, Texas From the Division of Plastic Surgery, Department of Surgery, University of Texas Medical Branch.

Background: Medical tourism has become increasingly globalized as individuals travel abroad to receive medical care. Cosmetic patients in particular are more likely to seek surgery abroad to defray costs. Unfortunately, not all procedures performed abroad adhere to strict hygienic regulations, and bacterial flora vary. Read More

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http://dx.doi.org/10.1097/PRS.0000000000005014DOI Listing
December 2018
2 Reads

Outbreak of Tattoo-Associated Nontuberculous Mycobacterial Skin Infections.

Clin Infect Dis 2018 Nov 17. Epub 2018 Nov 17.

Florida Department of Health in Miami-Dade County, Epidemiology, Disease Control, and Immunization Services, Miami, FL, USA.

Background: On April 29, 2015, the Florida Department of Health in Miami-Dade County (DOH-Miami-Dade) was notified by a local dermatologist of three patients with suspect nontuberculous mycobacterial (NTM) infection after receiving tattoos at a local tattoo studio.

Methods: DOH-Miami-Dade conducted interviews and offered testing, described below, to tattoo studio clients reporting rashes. Culture of clinical isolates and identification were performed at the Florida Bureau of Public Health Laboratories (BPHL). Read More

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http://dx.doi.org/10.1093/cid/ciy979DOI Listing
November 2018
13 Reads

Antimicrobial susceptibility testing of Mycobacteroides (Mycobacterium) abscessus complex, Mycolicibacterium (Mycobacterium) fortuitum, and Mycobacteroides (Mycobacterium) chelonae.

J Infect Chemother 2019 Feb 14;25(2):117-123. Epub 2018 Nov 14.

Department of Mycobacterium Reference and Research, The Research Institute of Tuberculosis, Japan Anti-tuberculosis Association, Kiyose, Japan; Basic Mycobacteriosis, Nagasaki University Graduate School of Biomedical Sciences, Nagasaki, Japan.

The drug susceptibility of rapidly growing mycobacteria (RGM) varies among isolates. Treatment strategies similarly differ depending on the isolate, and for some, no clear strategy has been identified. This complicates clinical management of RGM. Read More

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http://dx.doi.org/10.1016/j.jiac.2018.10.010DOI Listing
February 2019
3 Reads
1.384 Impact Factor

Association of non-tuberculous mycobacteria with Mycobacterium leprae in environment of leprosy endemic regions in India.

Infect Genet Evol 2018 Nov 13. Epub 2018 Nov 13.

The Leprosy Mission Trust India, Stanley Browne Laboratory, TLM community Hospital Nand Nagari, New Delhi 110093, India.

Non-tuberculous mycobacteria (NTM) are environmental mycobacteria found ubiquitously in nature. The present study was conducted to find out the presence of various species of NTM in leprosy endemic region along with Mycobacterium (M) leprae. Water and wet soil samples from the periphery of ponds used by the community were collected from districts of Purulia of West Bengal and Champa of Chhattisgarh, India. Read More

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https://linkinghub.elsevier.com/retrieve/pii/S15671348183088
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http://dx.doi.org/10.1016/j.meegid.2018.11.010DOI Listing
November 2018
14 Reads
3.015 Impact Factor

Mycobacterium fortuitum infection associated with achalasia.

Tunis Med 2018 May;96(5):311-313

The association achalasia and non tuberculous Mycobacteria lung infection is described in the literature. Most of the time Mycobacterium Fortuitum is responsible of aspiration pneumonia that didn't respond to usual antibiotic therapy. We report a new case about a 15 year-old woman with Allgrove's syndrome history. Read More

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May 2018
1 Read

Cutaneous Mycobacterial Infections.

Clin Microbiol Rev 2018 01 14;32(1). Epub 2018 Nov 14.

Servicio de Dermatología y Departamento de Micología, Hospital General de México, Mexico City, Mexico.

Humans encounter mycobacterial species due to their ubiquity in different environmental niches. In many individuals, pathogenic mycobacterial species may breach our first-line barrier defenses of the innate immune system and modulate the activation of phagocytes to cause disease of the respiratory tract or the skin and soft tissues, sometimes resulting in disseminated infection. Cutaneous mycobacterial infections may cause a wide range of clinical manifestations, which are divided into four main disease categories: (i) cutaneous manifestations of infection, (ii) Buruli ulcer caused by and other related slowly growing mycobacteria, (iii) leprosy caused by and , and (iv) cutaneous infections caused by rapidly growing mycobacteria. Read More

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http://dx.doi.org/10.1128/CMR.00069-18DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6302357PMC
January 2018
6 Reads

Epidemiology of pulmonary disease due to nontuberculous mycobacteria in Southern China, 2013-2016.

BMC Pulm Med 2018 Nov 9;18(1):168. Epub 2018 Nov 9.

National Clinical Laboratory on Tuberculosis, Beijing Key laboratory on Drug-resistant Tuberculosis Research,, Beijing Chest Hospital, Beijing Tuberculosis and Thoracic Tumor Institute, No. 9, Beiguan Street, Tongzhou District, Beijing, 101149, People's Republic of China.

Background: Pulmonary nontuberculous mycobacteria (NTM) disease is of increasing public health concern in China. Information is limited regarding risk factors associated with this disease in China. The objective of this study was to describe the epidemiology of pulmonary disease due to NTM in Southern China. Read More

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https://bmcpulmmed.biomedcentral.com/articles/10.1186/s12890
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http://dx.doi.org/10.1186/s12890-018-0728-zDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6230232PMC
November 2018
20 Reads
2.490 Impact Factor

Mycobacterium Fortuitum infection associated with achalasia.

Tunis Med 2018 Mar;96(3):227-229

The association between achalasia and no tuberculosis mycobacterial   lung infection is well described in the literature. MycobactériumFortuitum is often responsible, and the clinical's presentation   is an aspiration pneumonia resistant to usual antibiotic therapy. We report the case of a 15 year-old patient with the history of Allgrove syndrome. Read More

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March 2018
22 Reads

Genetic Diversity and Prevalence of Nontuberculous Mycobacteria Isolated from Clinical Samples in Tehran, Iran.

Microb Drug Resist 2019 Mar 25;25(2):264-270. Epub 2018 Sep 25.

1 Department of Mycobacteriology and Pulmonary Research, Pasteur Institute of Iran , Tehran, Iran .

The prevalence of nontuberculous mycobacteria (NTM) has increased in tuberculosis (TB)-suspected clinical samples. These bacteria are now recognized as important emerging pathogens, which affect both immunocompetent and immunocompromised individuals. The aim of this study was to evaluate the frequency of NTM in clinical samples and to efficacy of genomic loci as targets for detection of NTM species. Read More

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http://dx.doi.org/10.1089/mdr.2018.0150DOI Listing
March 2019
22 Reads
2.524 Impact Factor

The etiology and public health significance of mycobacteriosis of cattle in Kenya.

Int J Mycobacteriol 2018 Jul-Sep;7(3):251-256

State Department of Livestock, Central Veterinary Laboratories, Directorate of Veterinary Services, Ministry of Agriculture and Irrigation, Nairobi, Kenya.

Background: Zoonotic tuberculosis, commonly referred to as bovine, tuberculosis is mainly caused by Mycobacterium bovis subsp. bovis, a member of the mycobacterium tuberculosis complex (MTBC). Infection in humans resembles that caused by Mycobacterium tuberculosis. Read More

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http://www.ijmyco.org/text.asp?2018/7/3/251/240696
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http://dx.doi.org/10.4103/ijmy.ijmy_80_18DOI Listing
September 2018
5 Reads

Activity of PBTZ169 against Multiple Mycobacterium Species.

Antimicrob Agents Chemother 2018 Nov 24;62(11). Epub 2018 Oct 24.

National Clinical Laboratory on Tuberculosis, Beijing Key Laboratory on Drug-Resistant Tuberculosis Research, Beijing Chest Hospital, Capital Medical University, Beijing Tuberculosis and Thoracic Tumor Institute, Beijing, China

In this study, we demonstrate that PBTZ169 exhibits significant differences in activity against multiple species. The amino acid polymorphism at codon 387 of decaprenylphosphoryl-beta-d-ribose oxidase (DprE1) can be used as a surrogate marker for susceptibility to PBTZ169 in mycobacteria. In addition, the amino acid substitution at codon 154 in DprE1 may be associated with acquired resistance to PBTZ169 in the mutants. Read More

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http://dx.doi.org/10.1128/AAC.01314-18DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6201125PMC
November 2018
15 Reads
4.480 Impact Factor

Inactivation of two Mycobacteria by free chlorine: Effectiveness, influencing factors, and mechanisms.

Sci Total Environ 2019 Jan 4;648:271-284. Epub 2018 Aug 4.

Shanghai Institute of Pollution Control and Ecological Security, State Key Laboratory of Pollution Control and Resource Reuse, School of Environmental Science and Engineering, Tongji University, 1239 Siping Road, Shanghai 200092, People's Republic of China.

Chlorination is one of the most widely used disinfection techniques, and the problem of "chlorine-resistant bacteria" (CRB) has attracted more attention recently. In this study, the deactivation of typical CRB in water, Mycobacterium fortuitum (M. fortuitum) and Mycobacterium mucogenicum (M. Read More

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https://linkinghub.elsevier.com/retrieve/pii/S00489697183294
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http://dx.doi.org/10.1016/j.scitotenv.2018.07.451DOI Listing
January 2019
10 Reads

Breast Implant Mycobacterial Infections: An Epidemiologic Review and Outcome Analysis.

Plast Reconstr Surg 2018 11;142(5):639e-652e

Montreal, Quebec, Canada; Nicosia, Cyprus; and Riyadh, Saudi Arabia From the Divisions of Plastic and Reconstructive Surgery and Infectious Disease, McGill University Health Centre; St. George's University of London MBBS Program at University of Nicosia Medical School; and the Division of Plastic Surgery, Department of Surgery, King Saud University.

Background: Epidemiologic evidence of periprosthetic mycobacterial infections is limited. The recent boom in cosmetic surgery tourism has been associated with a rise of surgical-site infections in returning patients. This review aims to explore available data, examine trends of documented periprosthetic mycobacterial infections, and analyze outcomes of management techniques. Read More

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http://dx.doi.org/10.1097/PRS.0000000000004892DOI Listing
November 2018
16 Reads

Post-Facelift Infection Due to Mycobacterium Fortuitum: A Case Report.

Isr Med Assoc J 2018 Aug;20(8):524-525

Department of Infectious Diseases, Emek Medical Center, Afula, Israel.

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August 2018
2 Reads

High rates of Mycobacterium fortuitum isolation in respiratory samples from Iranian patients with suspected tuberculosis: is it clinically important?

J Med Microbiol 2018 Sep 27;67(9):1243-1248. Epub 2018 Jul 27.

3​Microbiology Research Center (MRC), Pasteur Institute of Iran, Tehran, Iran.

Purpose: Although Mycobacterium fortuitum (M. fortuitum) is not an organism rarely isolated from respiratory samples, its clinical importance is still not fully understood, which therefore prompted our current study.

Methodology: We evaluated respiratory samples from 6800 patients with suspected tuberculosis from May 2014 to May 2016, for the detection of M. Read More

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http://dx.doi.org/10.1099/jmm.0.000814DOI Listing
September 2018
4 Reads

A totally implantable venous access port associated with bloodstream infection caused by Mycobacterium fortuitum: A case report.

Medicine (Baltimore) 2018 Jul;97(29):e11493

Department of Clinical Laboratory.

Rationale: Rapidly growing mycobacteria (RGM) are well-known causative agents of human infections, particularly in immunocompromised hosts. However, Mycobacterium fortuitum, a predominant organism, in catheter-associated infections, has rarely been documented in totally implantable venous access port (TVIAP)-associated bloodstream infections.

Patient Concerns: A 25-year-old woman with breast cancer presented to hospital with repeated fever for several days. Read More

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http://dx.doi.org/10.1097/MD.0000000000011493DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6086552PMC
July 2018
10 Reads
5.723 Impact Factor

Comparison of polymerase chain reaction-restriction enzyme analysis method and DNA sequence analysis results in the identification of non-tuberculous mycobacteria.

Acta Microbiol Immunol Hung 2018 Dec 16;65(4):515-527. Epub 2018 Jul 16.

1 Department of Medical Microbiology, Dokuz Eylul University , İzmir, Turkey.

The typing of non-tuberculous mycobacteria (NTM) is important from a clinical and epidemiological perspective. The polymerase chain reaction-restriction enzyme analysis (PRA) method and DNA sequence analysis method were utilized to target a gene region that codes the 65-kDa heat-shock protein for typing 150 suspected NTM samples isolated from the respiratory tract. Mycobacterium abscessus, Mycobacterium xenopi, Mycobacterium fortuitum, and Mycobacterium peregrinum were most frequently found by both methods. Read More

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http://dx.doi.org/10.1556/030.65.2018.027DOI Listing
December 2018
9 Reads

In Vitro Anti-mycobacterial Activity of Three Medicinal Plants of Lamiaceae Family.

Recent Pat Antiinfect Drug Discov 2018 ;13(3):240-245

Department of Medical Microbiology, School of Medicine, Tehran University of Medical Sciences, Tehran, Iran.

Background: Mycobacterium tuberculosis as an intracellular pathogen causes Tuberculosis (TB). Due to the long time required for treatment, hepatotoxicity of drugs and also emergence of Multidrug-Resistant (MDR) and Extremely Drug Resistant (XDR) strains, TB is currently a major public health problem. Some medicinal plants possess remarkable activity against Mycobacterium. Read More

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http://dx.doi.org/10.2174/1574891X13666180626170155DOI Listing
April 2019
21 Reads

Comparative evaluation of the identification of rapidly growing non-tuberculous mycobacteria by mass spectrometry (MALDI-TOF MS), GenoType Mycobacterium CM/AS assay and partial sequencing of the rpoβ gene with phylogenetic analysis as a reference method.

Enferm Infecc Microbiol Clin 2019 03 2;37(3):160-166. Epub 2018 Jun 2.

Servicio de Microbioloxía, Hospital Clínico Universitario de Santiago de Compostela, Santiago de Compostela, A Coruña, Spain.

Introduction: The American Thoracic Society and the Infectious Diseases Society of America recommend that clinically significant non-tuberculous mycobacteria (NTM) should be identified to the species level in order to determine their clinical significance. The aim of this study was to evaluate identification of rapidly growing NTM (RGM) isolated from clinical samples by using MALDI-TOF MS and a commercial molecular system. The results were compared with identification using a reference method. Read More

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https://linkinghub.elsevier.com/retrieve/pii/S0213005X183018
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http://dx.doi.org/10.1016/j.eimc.2018.04.012DOI Listing
March 2019
15 Reads

Scientific rationale for traditional use of plants to treat tuberculosis in the eastern region of the OR Tambo district, South Africa.

J Ethnopharmacol 2018 Oct 2;224:250-260. Epub 2018 Jun 2.

Phytomedicine Programme, Department of Paraclinical Sciences, University of Pretoria, Private Bag X04, Onderstepoort, 0110 Pretoria, South Africa. Electronic address:

Ethnopharmacological Relevance: Tuberculosis (TB) remains a major health problem for humans worldwide, and was responsible for 1.4 million human deaths in 2015 alone. Although there is treatment for TB, emerging multi-drug, extensively drug and totally drug resistant forms of this disease, as well as co-infection with human immunodefiency virus (HIV) continue to worsen the situation. Read More

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https://linkinghub.elsevier.com/retrieve/pii/S03788741183093
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http://dx.doi.org/10.1016/j.jep.2018.06.002DOI Listing
October 2018
38 Reads

The first Saudi Arabian national inventory study revealed the upcoming challenges of highly diverse non-tuberculous mycobacterial diseases.

PLoS Negl Trop Dis 2018 05 25;12(5):e0006515. Epub 2018 May 25.

Department of Infection and Immunity, King Faisal Specialist Hospital and Research Centre, Riyadh, Saudi Arabia.

Background: Incidences of nontuberculous mycobacteria (NTM) causing pulmonary and extrapulmonary diseases are reportedly increasing globally and the current epidemiologic situation in Saudi Arabia remains unclear. To study such trend, we carried out a nationwide systematic epidemiological study focusing on NTM diseases for the first time in the country.

Methods/principle Findings: A nationwide collection of NTM isolates with clinical and demographical data was conducted for a period of 24 months. Read More

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http://dx.doi.org/10.1371/journal.pntd.0006515DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5991771PMC

Profiling non-tuberculous mycobacteria in an Asian setting: characteristics and clinical outcomes of hospitalized patients in Singapore.

BMC Pulm Med 2018 May 22;18(1):85. Epub 2018 May 22.

Department of Respiratory and Critical Care Medicine, Tan Tock Seng Hospital, 11 Jalan Tan Tock Seng, Singapore, 308433, Singapore.

Background: Non-tuberculous mycobacteria (NTM) infection is an increasing problem worldwide. The epidemiology of NTM in most Asian countries is unknown. This study investigated the epidemiology, and clinical profile of inpatients in whom NTM was isolated from various anatomical sites in a Singaporean population attending a major tertiary referral centre. Read More

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http://dx.doi.org/10.1186/s12890-018-0637-1DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5964916PMC
May 2018
15 Reads

Preliminary Study on Drug Susceptibility Profile and Resistance Mechanisms to Macrolides of Clinical Isolates of Non-tuberculous Mycobacteria from China.

Biomed Environ Sci 2018 Apr;31(4):290-299

State Key Laboratory for Infectious Diseases Prevention and Control, Collaborative Innovation Center for Diagnosis and Treatment of Infectious Diseases, National Institute for Communicable Disease Control and Prevention, Chinese Center for Disease Control and Prevention, Beijing 102206, China.

Objective: Macrolide susceptibility and drug resistance mechanisms of clinical non-tuberculous mycobacteria (NTM) isolates were preliminarily investigated for more accurate diagnosis and treatment of the infection in China.

Methods: Four macrolides, including clarithromycin (CLAR), azithromycin (AZM), roxithromycin (ROX), and erythromycin (ERY), were used to test the drug susceptibility of 310 clinical NTM isolates from six provinces of China with the broth microdilution method. Two resistance mechanisms, 23S rRNA and erm, were analyzed with nucleotide sequence analysis. Read More

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http://dx.doi.org/10.3967/bes2018.037DOI Listing
April 2018
16 Reads

Cutaneous Nontuberculous Mycobacterial Infections in Alberta, Canada: An Epidemiologic Study and Review.

J Cutan Med Surg 2018 Sep/Oct;22(5):479-483. Epub 2018 May 17.

3 Division of Diagnostic and Applied Microbiology, Department of Laboratory Medicine and Pathology, University of Alberta and the Alberta Provincial Public Health Laboratory, WC Mackenzie Health Sciences Centre, Edmonton, AB, Canada.

Background: Cutaneous infections caused by nontuberculous mycobacteria (NTM) occur infrequently. Nonetheless, the incidence of NTM infections is reported to be increasing. In Canada, cutaneous NTM infections have not been well described. Read More

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http://dx.doi.org/10.1177/1203475418776945DOI Listing
December 2018
17 Reads

Activity of Clofazimine against Nontuberculous Mycobacteria Isolated in Beijing, China.

Antimicrob Agents Chemother 2018 Jul 26;62(7). Epub 2018 Jun 26.

National Clinical Laboratory on Tuberculosis, Beijing Key laboratory for Drug-Resistant Tuberculosis Research, Beijing Chest Hospital, Capital Medical University, Beijing Tuberculosis and Thoracic Tumor Institute, Beijing, China

Due to the natural resistance of nontuberculous mycobacteria (NTM) to many antibiotics, the treatment of diseases caused by NTM is often long-term but unsuccessful. The main goal of this study was to evaluate the susceptibilities to clofazimine of 209 isolates consisting of different NTM species isolated in Beijing, China. Furthermore, 47 reference strains were also tested, including 30 rapidly growing mycobacterium (RGM) species and 17 slowly growing mycobacterium (SGM) species. Read More

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http://dx.doi.org/10.1128/AAC.00072-18DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6021646PMC
July 2018
11 Reads

Draft Genome Sequence of Mycobacterium porcinum CSURP1564.

Genome Announc 2018 Apr 19;6(16). Epub 2018 Apr 19.

Aix Marseille Université, IRD, APHM, MEPHI, IHU-Méditerranée Infection, Marseille, France

is a rapidly growing environmental mycobacterium responsible for opportunistic infections. The 7,025,616-bp draft genome of strain CSURP1564 exhibits a 66.71% G+C content, 6,687 protein-coding genes, and 65 predicted RNA genes. Read More

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http://genomea.asm.org/lookup/doi/10.1128/genomeA.00291-18
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http://dx.doi.org/10.1128/genomeA.00291-18DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5908923PMC
April 2018
3 Reads

Non-tuberculous Mycobacterium species causing mycobacteriosis in farmed aquatic animals of South Africa.

BMC Microbiol 2018 04 13;18(1):32. Epub 2018 Apr 13.

Tuberculosis Laboratory, Agricultural Research Council - Onderstepoort Veterinary Research, Onderstepoort, South Africa.

Background: Mycobacteriosis caused by non-tuberculous mycobacteria (NTM), is among the most chronic diseases of aquatic animals. In addition, fish mycobacteriosis has substantial economic consequences especially in the aquaculture and fisheries industry as infections may significantly decrease production and trade. Some fish NTM pathogens are highly virulent and zoonotic; as such, infection of aquaria with these pathogens is a public health concern. Read More

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https://bmcmicrobiol.biomedcentral.com/articles/10.1186/s128
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http://dx.doi.org/10.1186/s12866-018-1177-9DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5899368PMC
April 2018
14 Reads

Evaluation of the Vitek MS v3.0 Matrix-Assisted Laser Desorption Ionization-Time of Flight Mass Spectrometry System for Identification of Mycobacterium and Nocardia Species.

J Clin Microbiol 2018 06 25;56(6). Epub 2018 May 25.

ARUP Laboratories, Salt Lake City, Utah, USA

This multicenter study was designed to assess the accuracy and reproducibility of the Vitek MS v3.0 matrix-assisted laser desorption ionization-time of flight (MALDI-TOF) mass spectrometry system for identification of and species compared to DNA sequencing. A total of 963 clinical isolates representing 51 taxa were evaluated. Read More

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http://dx.doi.org/10.1128/JCM.00237-18DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5971548PMC
June 2018
11 Reads

Atypical Mycobacterial Infections of the Upper Extremity.

Orthopedics 2018 May 26;41(3):e383-e388. Epub 2018 Mar 26.

Atypical mycobacterial infections of upper extremity synovial-lined structures are often misdiagnosed and unrecognized. Despite an increasing incidence, lack of physician awareness of these pathogens may result in considerable delay in diagnosis and management, potentially leading to permanent disability. The authors conducted a literature review and analyzed 31 cases of penetrating atypical mycobacterial infection to better understand the clinical characteristics and to evaluate their posttreatment complication rate compared with available literature. Read More

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http://dx.doi.org/10.3928/01477447-20180320-06DOI Listing
May 2018
6 Reads

Non-Tuberculous Mycobacterial Infections Related to Peritoneal Dialysis.

Perit Dial Int 2018 Mar-Apr;38(2):147-149

Division of Endocrinology, Metabolism and Nephrology, Department of Internal Medicine, School of Medicine, Keio University, Tokyo, Japan.

Most infections related to peritoneal dialysis (PD) are caused by common bacteria, and non-tuberculous mycobacteria are rare. The clinical characteristics and prognosis of PD patients with non-tuberculous mycobacterial infections were investigated at our hospital. Non-tuberculous mycobacteria were detected in 11 patients (exit-site infection, tunnel infection, and peritonitis in 3, 5, and 3 patients, respectively). Read More

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http://www.pdiconnect.com/lookup/doi/10.3747/pdi.2017.00172
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http://dx.doi.org/10.3747/pdi.2017.00172DOI Listing
December 2018
16 Reads

-induced ER-Mitochondrial calcium dynamics promotes calpain/caspase-12/caspase-9 mediated apoptosis in fish macrophages.

Cell Death Discov 2018 Dec 20;4:30. Epub 2018 Feb 20.

1Department of Zoology, Immunobiology Laboratory, University of Delhi, Delhi, India.

is a natural fish pathogen. It induces apoptosis in headkidney macrophages (HKM) of catfish, sp though the mechanism remains largely unknown. We observed triggers calcium (Ca) insult in the sub-cellular compartments which elicits pro-apototic ER-stress factor CHOP. Read More

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http://dx.doi.org/10.1038/s41420-018-0034-9DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5841318PMC
December 2018
2 Reads