2,115 results match your criteria Mycobacterium Fortuitum


Mycobacterium fortuitum Prosthetic Joint Infection After Total Hip Arthroplasty: A Case Report.

JBJS Case Connect 2020 Apr-Jun;10(2):e0343

1Perelman School of Medicine at the University of Pennsylvania, Philadelphia, Pennsylvania 2Department of Orthopaedic Surgery, Adult Hip and Knee Reconstruction, Hospital of the University of Pennsylvania, Philadelphia, Pennsylvania 3Section of Infectious Diseases, Pennsylvania Hospital, Philadelphia, Pennsylvania.

Case: A 57-year-old man presented with a Mycobacterium fortuitum prosthetic joint infection (PJI) after right total hip arthroplasty refractory to the initial revision surgery and cement spacer placement. The patient was subsequently treated with 2-stage total joint arthroplasty revision surgery using an antibiotic-laden spacer customized to include meropenem and delayed reimplantation to allow for prolonged, systemic antimicrobial treatment with multiple antimicrobials, including levofloxacin and linezolid.

Conclusions: There is little evidence to guide practitioners in the diagnosis and treatment of PJI caused by rare, rapidly growing mycobacteria (RGM) such as M. Read More

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http://dx.doi.org/10.2106/JBJS.CC.18.00343DOI Listing

Nodular distribution pattern on chest computed tomography (CT) in patients diagnosed with nontuberculous mycobacteria (NTM) infections.

Wien Klin Wochenschr 2020 Jul 2. Epub 2020 Jul 2.

Emergency Department of Zagreb County, Matice Hrvatske, Zagreb, Croatia.

Background: This study evaluated the prevalence of spreading pathways in nontuberculous mycobacteria (NTM) pulmonary infections according to nodular distribution patterns seen on chest computed tomography (CT).

Methods: This study included 63 patients diagnosed with NTM lung infections who underwent CT at our institution. A retrospective analysis of CT images focused on the presence and distribution of nodules, presence of intrathoracic lymphadenopathy and the predominant side of infection in the lungs. Read More

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http://dx.doi.org/10.1007/s00508-020-01701-1DOI Listing

The Use of Amikacin Liposome Inhalation Suspension (Arikayce) in the Treatment of Refractory Nontuberculous Mycobacterial Lung Disease in Adults.

Drug Des Devel Ther 2020 10;14:2287-2294. Epub 2020 Jun 10.

Division of Pulmonary Disease and Critical Care Medicine, Department of Medicine, Virginia Commonwealth University, Richmond, VA, USA.

Nontuberculous mycobacteria (NTM) can cause and perpetuate chronic inflammation and lung infection. Despite having the diagnostic criteria, as defined by the American Thoracic Society (ATS) and Infectious Diseases Society of America (IDSA), clinicians find it challenging to diagnose and treat NTM-induced lung disease. Inhaled antibiotics are suitable for patients with lung infection caused by and other organisms, but until recently, their utility in NTM-induced infection was not established. Read More

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http://dx.doi.org/10.2147/DDDT.S146111DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7293904PMC

Nail Salon a Potential Source of a Rare Mycobacterium Fortuitum Infection In Proximal Tibia Megaprosthesis? A Case Report.

J Bone Jt Infect 2020 27;5(3):133-136. Epub 2020 Apr 27.

Department of Orthopedic Surgery, Morristown Medical Center, Morristown, NJ.

Mycobacterium Fortuitum (M. Fortuitum) is a type of opportunistic pathogen commonly found in water/soil and belongs to the nontuberculosis mycobacteria (NTM) family. Prosthetic joint infection due to M. Read More

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http://dx.doi.org/10.7150/jbji.43023DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7295650PMC

Use of MALDI-TOF MS (Bruker Daltonics) for identification of Mycobacterium species isolated directly from liquid medium.

Enferm Infecc Microbiol Clin 2020 Jun 11. Epub 2020 Jun 11.

Servicio de Microbiología, Hospital Universitario Miguel Servet. IIS Aragón, Zaragoza, Spain; Grupo de estudio de las Infecciones por Micobacterias (GEIM), Sociedad Española de Microbiología y Enfermedades Infecciosas, Spain.

Objectives: The aim of this study was to describe the evaluation of the use of MALDI-TOF MS for the identification of non-tuberculous mycobacteria (NTM) and Mycobacterium tuberculosis directly from liquid MGIT cultures from January 2017 to December 2017.

Material/methods: A total of 155 isolates (mainly respiratory) were analyzed by MALDI-TOF MS (Bruker Daltonics) directly from MGIT liquid medium with a previous extraction procedure.

Results: MALDI-TOF MS generated acceptable scores for 152 isolates (98. Read More

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http://dx.doi.org/10.1016/j.eimc.2020.05.011DOI Listing

Clinical-epidemiological profile and factors related to the mortality of patients with nontuberculous mycobacteria isolated at a reference hospital in Ceará, Northeastern Brazil.

Int J Mycobacteriol 2020 Jan-Mar;9(1):83-90

São José Hospital of Infectious Diseases; Department of Community Health, School of Medicine, Federal University of Ceará, Fortaleza, Ceará, Brazil.

Background: There is a significant shortage of official records that enable estimating the real prevalence of nontuberculous mycobacteria (NTM) infections in Brazil. The study aims to investigate the clinical, laboratory, and epidemiological aspects of patients with NTM isolation at an infectious diseases reference hospital, and to identify factors associated with mortality.

Methods: This was an observational study in which clinical, epidemiological, and laboratory aspects were evaluated in patients with NTM isolated at care in Hospital São José, located in Northeastern Brazil, from 2005 to 2016. Read More

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http://dx.doi.org/10.4103/ijmy.ijmy_12_20DOI Listing

An overview of pulmonary infections due to rapidly growing mycobacteria in South Asia and impressions from a subtropical region.

Int J Mycobacteriol 2020 Jan-Mar;9(1):62-70

Department of Microbiology, Vallabhbhai Patel Chest Institute, University of Delhi, Delhi, India.

Background: Rapidly growing mycobacteria (RGM) comprise nearly half of the validated species of nontuberculous mycobacteria (NTM) and have been reported to have a higher incidence in Asia as compared to Europe and America. There is limited information on RGM infections from South Asia. Hence, the present study aimed to ascertain the incidence of pulmonary infections due to RGM in Delhi and to review the status of available information on the prevalence of RGM in South Asia, a region endemic for tuberculosis. Read More

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http://dx.doi.org/10.4103/ijmy.ijmy_179_19DOI Listing

A Current Microbiological Picture of Isolates from Istanbul, Turkey.

Pol J Microbiol 2020 ;69:1-7

Beykoz Institute of Life Sciences and Biotechnology , Bezmialem Vakıf University , Istanbul , Turkey.

Despite advances in diagnosis and treatment, tuberculosis (TB) continues to be one of the essential health problems throughout the world. Turkey is considered to be endemic for TB. In this study, we analyzed the distribution of species, compare the diagnostic methods, and susceptibilities to anti-tuberculosis drugs of TB isolates. Read More

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http://dx.doi.org/10.33073/pjm-2020-021DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7324856PMC
January 2020

Successful bedaquiline-containing antimycobacterial treatment in post-traumatic skin and soft-tissue infection by Mycobacterium fortuitum complex: a case report.

BMC Infect Dis 2020 May 24;20(1):365. Epub 2020 May 24.

Technical University of Munich, School of Medicine, University Hospital Rechts der Isar, Department of Internal Medicine II, Ismaningerstrasse 22, 81675, Munich, Germany.

Background: Mycobacterium fortuitum complex is a group of rapidly growing nontuberculous mycobacteria (NTM) associated with skin and soft-tissue infections after surgery or trauma. Treatment of NTM is challenging, due to resistance to multiple antimycobacterial agents. Bedaquiline is a diarylquinoline that inhibits mycobacterial ATP-synthase. Read More

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http://dx.doi.org/10.1186/s12879-020-05075-7DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7245858PMC

Nontuberculous mycobacterial infection in a tertiary care center in Mexico, 2001-2017.

Braz J Infect Dis 2020 May 16. Epub 2020 May 16.

Instituto Nacional de Ciencias Médicas y Nutrición Salvador Zubirán, Department of Infectious Diseases, Laboratory of Clinical Microbiology, Mexico City, Mexico. Electronic address:

Introduction: Nontuberculous mycobacteria (NTM) comprise several pathogens with a complex profile of virulence, diverse epidemiological and clinical patterns as well as host specificity. Recently, an increase in the number of NTM infections has been observed; therefore, the objective of this study was to evaluate the clinical characteristics and outcomes of these infections.

Methods: We included patients with NTM infections between 2001-2017 and obtained risk factors, clinical features and outcomes; finally, we compared this data between slowly growing (SGM) and rapidly growing mycobacteria (RGM). Read More

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http://dx.doi.org/10.1016/j.bjid.2020.04.012DOI Listing

ISOLATION AND ANTIMICROBIAL SUSCEPTIBILITIES OF NONTUBERCULOUS MYCOBACTERIA FROM WILDLIFE IN JAPAN.

J Wildl Dis 2020 May 13. Epub 2020 May 13.

Department of Applied Veterinary Sciences, United Graduate School of Veterinary Sciences, Gifu University, 1-1 Yanagido, Gifu 501-1193, Japan.

Nontuberculous mycobacteria (NTM) are opportunistic pathogens of humans and animals and are transmitted among the environment, wildlife, livestock, and humans. The aim of this study was to investigate the rate of isolation and antimicrobial susceptibility of NTM in wildlife. In total, 178 samples of feces (=131) and tissues (=47) were collected from 11 wildlife species in Gifu Prefecture and Mie Prefecture, Japan, between June 2016 and October 2018. Read More

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http://dx.doi.org/10.7589/2019-10-261DOI Listing

Assessment of current diagnostic algorithm for detection of mixed infection with Mycobacterium tuberculosis and nontuberculous mycobacteria.

J Infect Public Health 2020 Apr 22. Epub 2020 Apr 22.

National Clinical Laboratory on Tuberculosis, Beijing Key Laboratory on Drug-resistant Tuberculosis Research, Beijing Chest Hospital, Capital Medical University, Beijing Tuberculosis and Thoracic Tumor Institute, Beijing, China. Electronic address:

Background: The increasing pulmonary diseases are reported to be affected by mixed infection of Mycobacterium tuberculosis (MTB) and nontuberculous mycobacteria (NTM). In this study, our objective was to assess the efficiency of mycobacterial culture plus DNA sequencing to detect the mixed infections with MTB and various NTM organisms. We also aimed to investigate how efficiently GeneXpert detected MTB in mixed infections with NTM in in vitro models. Read More

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http://dx.doi.org/10.1016/j.jiph.2020.03.017DOI Listing

Atypical cutaneous mycobacteriosis caused by M. fortuitum acquired in domestic environment.

An Bras Dermatol 2020 May - Jun;95(3):390-391. Epub 2020 Mar 13.

Department of Medical Clinic, Faculdade de Ciências Médicas, Universidade Estadual de Campinas, Campinas, SP, Brazil.

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http://dx.doi.org/10.1016/j.abd.2019.06.012DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7253846PMC
June 2020
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Odontogenic cutaneous sinus tracts due to infection with nontuberculous mycobacteria: a report of three cases.

BMC Infect Dis 2020 Apr 21;20(1):295. Epub 2020 Apr 21.

Departamento Laboratorio de Tuberculosis. Instituto de Biomedicina "Dr. Jacinto Convit", Universidad Central de Venezuela, Caracas, Venezuela.

Background: Soft tissue or skin infections due to nontuberculous mycobacteria (NTM) have been reported frequently and are mostly associated with trauma or cosmetic interventions like plastic surgery. However, infection with NTM as a result of a dental procedure have rarely been described and the lack of clinical suspicion and a clear clinical manifestation makes diagnosis challenging.

Case Presentation: We report on three patients with a facial cutaneous sinus tract of dental origin, due to an infection with respectively Mycobacterium fortuitum, M. Read More

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http://dx.doi.org/10.1186/s12879-020-05015-5DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7171849PMC

Skin infections by Mycobacterium chelonae following mesotherapy: A report of two cases and review of the literature.

J Cosmet Dermatol 2020 Apr 15. Epub 2020 Apr 15.

Department of Pathophysiology and Transplantation, Università degli Studi, IRCCS Foundation, Cà Granda Ospedale Maggiore Policlinico, Milan, Italy.

Mesotherapy is sometimes responsible for dermal and subcutaneous infections caused by nontuberculous mycobacteria. Mycobacterium chelonae, M abscessus, and M fortuitum are usually involved. We present two cases of deep skin infections caused by M chelonae following mesotherapy. Read More

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http://dx.doi.org/10.1111/jocd.13441DOI Listing

Nontuberculous mycobacterial infections in left ventricular assist device patients.

J Card Surg 2020 May 6;35(5):1138-1141. Epub 2020 Apr 6.

Yale School of Medicine, New Haven, Connecticut.

Left ventricular assist devices (LVADs) are integral for the management of medically refractory heart failure, and LVAD infections are common following device placement. Most infections are caused by Staphylococcal spp. and Gram-negative enteric bacteria but nontuberculous mycobacterial (NTM) infections have been reported. Read More

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http://dx.doi.org/10.1111/jocs.14530DOI Listing

Comparison of in vitro Susceptibility of Mycobacteria Against PA-824 to Identify Key Residues of Ddn, the Deazoflavin-Dependent Nitroreductase from .

Infect Drug Resist 2020 11;13:815-822. Epub 2020 Mar 11.

National Clinical Laboratory on Tuberculosis, Beijing Key Laboratory on Drug-Resistant Tuberculosis Research, Beijing Chest Hospital, Capital Medical University, Beijing Tuberculosis and Thoracic Tumor Institute, Beijing, People's Republic of China.

Objective: PA-824 (Pretomanid), a bicyclic nitroimidazole drug, exhibits significant bactericidal activity toward (MTB) in vitro and in vivo, but not against . Through catalytic bioreduction, deazaflavin-dependent nitroreductase (Ddn) within MTB directly converts PA-824 to potent bactericidal products. This study aimed to identify key MTB Ddn residues involved in PA-824 conversion toward development of in vitro surrogate markers for detection of mycobacterial resistance to PA-824. Read More

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http://dx.doi.org/10.2147/IDR.S240716DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7073430PMC

Fiber optic interferometric immunosensor based on polydimethilsiloxane (PDMS) and bioactive lipids.

Biomed Opt Express 2020 Mar 10;11(3):1316-1326. Epub 2020 Feb 10.

Instituto de Investigaciones en Materiales, Universidad Nacional Autónoma de México, Ciudad Universitaria, 04510, Ciudad de México, Mexico.

We demonstrate a novel and simple means to fabricate optical fiber immunosensors based on Fabry-Perot (F-P) interferometers using polydimethylsiloxane (PDMS) as support for bioactive lipids. The sensors are fabricated following a straightforward dip-coating method producing PDMS end-capped devices. A biosensing platform is realized by subsequent functionalization of the PDMS cap with a previously characterized bioactive lipid antigen cocktail from , used as a surrogate source of antigens for tuberculosis diagnosis. Read More

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http://dx.doi.org/10.1364/BOE.379518DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7075606PMC

Detection of Wood Mice () Carrying Non-Tuberculous Mycobacteria Able to Infect Cattle and Interfere with the Diagnosis of Bovine Tuberculosis.

Microorganisms 2020 Mar 6;8(3). Epub 2020 Mar 6.

NEIKER-Instituto Vasco de Investigación y Desarrollo Agrario, Animal Health Department, Bizkaia Science and Technology Park 812L, 48160 Derio (Bizkaia), Spain.

Mycobacterial infections caused by the complex (MTC) and non-tuberculous mycobacteria (NTM) are of great medical and veterinary relevance. The aim of this research was to study whether small mammals play a role in the epidemiology of mycobacterioses. Four samplings of 100 traps were performed in each of three cattle farms with previous history of tuberculosis or NTM between 2017 and 2018. Read More

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http://dx.doi.org/10.3390/microorganisms8030374DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7143357PMC

Incidence, Clinical Manifestation, Treatment Outcome, and Drug Susceptibility Pattern of Nontuberculous Mycobacteria in HIV Patients in Tehran, Iran.

Ethiop J Health Sci 2020 Jan;30(1):75-84

Department of Microbiology, School of Medicine, Tehran University of Medical Sciences, Tehran, Iran.

Background: Nontuberculous mycobacterial (NTM) infections have radically increased worldwide due to the increase in HIV infections. The disease activity increases with progressive immunodeficiency.

Methods: A total of 216 HIV seropositive patients suspected of having mycobacterial infection were recruited for this study. Read More

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http://dx.doi.org/10.4314/ejhs.v30i1.10DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7036467PMC
January 2020

Non-tuberculous mycobacteria profiles and their anti-mycobacterial resistance at a major medical center in Lebanon.

J Infect Dev Ctries 2019 07 31;13(7):612-618. Epub 2019 Jul 31.

Department of Pathology and Laboratory Medicine, American University of Beirut Medical Center, Beirut, Lebanon.

Introduction: Infection with non-tuberculosis mycobacteria (NTM) has been on the rise globally causing a wide spectrum of respiratory and extrapulmonary infections in humans. Studies on these pathogens from the Middle-East including Lebanon are scarce.

Methodology: This retrospective study addresses the approach used for investigation, speciation and antimicrobial resistance (AMR) profiles of recovered NTM isolates from respiratory sources at a major tertiary care center in Lebanon during two periods (2003-2007 and 2013-2017). Read More

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http://dx.doi.org/10.3855/jidc.11028DOI Listing

Epidemiology of Non-Tuberculous Mycobacteria isolated from clinical specimens in Madrid, Spain, from 2013 to 2017.

Eur J Clin Microbiol Infect Dis 2020 Jun 24;39(6):1089-1094. Epub 2020 Jan 24.

Department of Clinical Microbiology, IIS-Fundación Jiménez Díaz, Madrid, Spain.

The epidemiology of non-tuberculous mycobacteria (NTM) in Spain is largely unknown because systematic reporting is not compulsory. The aim of our study was to describe the frequency and diversity of NTM species in our region and their distribution according to the source sample, gender, and age of the patients. We performed a multicenter study of all NTM isolated in 24 public hospitals in Madrid from 2013 to 2017. Read More

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http://dx.doi.org/10.1007/s10096-020-03826-7DOI Listing

Minimum inhibitory concentration changes in relapsed left ventricular assist device driveline infections.

Int J Artif Organs 2020 Jul 22;43(7):494-499. Epub 2020 Jan 22.

Division of Infectious Diseases, Department of Medicine, Vanderbilt University Medical Center, Nashville, TN, USA.

Driveline infection is the most common infectious complication in patients with left ventricular assist devices. Minimum inhibitory concentration changes are not well described in relapsed driveline infections. This retrospective descriptive epidemiology study of patients with left ventricular assist device implantation between January 1, 2013, and August 1, 2017, who developed driveline infection with positive cultures aimed to describe minimum inhibitory concentration changes. Read More

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http://dx.doi.org/10.1177/0391398819900188DOI Listing

Identification of Non-Tuberculosis Mycobacteria by Line Probe Assay and Determination of Drug Resistance Patterns of Isolates in Iranian Patients.

Arch Razi Inst 2019 12 1;74(4):375-384. Epub 2019 Dec 1.

Department of Microbiology, School of medicine, Tehran University of Medical Sciences, Tehran, Iran.

The potentially pathogenic Non-Tuberculosis Mycobacteria (NTM) are emerging nowadays which result in pulmonary and non-pulmonary infections in human. This group of bacteria consists of at least 200 different species. While the pulmonary disease is the most common form of NTM infections, NTM can cause diffused infections as well as extrapulmonary infections in every organ, such as bone marrow, skin, eye, and brain. Read More

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http://dx.doi.org/10.22092/ari.2019.127144.1372DOI Listing
December 2019

Pseudo-outbreak of Mycobacterium fortuitum in a hospital bronchoscopy unit.

Am J Infect Control 2020 Jul 24;48(7):765-769. Epub 2019 Dec 24.

Microbiology and Infection Control Service, University Hospital Complex of the Canary Islands, Santa Cruz de Tenerife, Canary Islands, Spain.

Background: Mycobacterium fortuitum survive in different environmental conditions, biofilm formation and resistance to chlorinated disinfectants makes its isolation frequent in hospital environments, even being involved in outbreaks by contamination of medical equipment such as bronchoscopes. We describe a pseudo-outbreak by M fortuitum isolated in samples from 9 patients who underwent bronchoscopy in the pneumology bronchoscopy unit of the University Hospital Complex of the Canary Islands from December 2016 to March 2017.

Methods: We proceeded to investigate the pseudo-outbreak with a combination of epidemiologic, environmental, and molecular typing data. Read More

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http://dx.doi.org/10.1016/j.ajic.2019.11.019DOI Listing

Identification of mycobacteria species by molecular methods.

Int Wound J 2020 Apr 20;17(2):245-250. Epub 2019 Dec 20.

Health Services Vocational School, Trakya University, Edirne, Turkey.

In this study, mycobacteria, which were previously identified as Mycobacterium tuberculosis complex (MTC), and mycobacteria other than tuberculosis (MOTT) with cord factor and the p-nitro-alpha-acetyl-amino-beta-hydroxypropiophenone (NAP) test were reanalysed using the polymerase chain reaction-restriction fragment length polymorphism (PCR-RFLP) analysis method in order to confirm the identification, and at the same time, species accepted as MOTT were identified. Although the results of the NAP test were obtained within 3-5 days, the PCR-RFLP results were obtained in 1 day. Ten species identified as MTC with the NAP test and cord factor were confirmed with the PCR-RFLP method. Read More

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http://dx.doi.org/10.1111/iwj.13238DOI Listing

Surgical Site Infection Caused by Mycobacterium Septicum Following Blepharoplasty.

J Craniofac Surg 2020 May/Jun;31(3):e228-e230

Department of Plastic and Reconstructive Surgery, College of Medicine, The Catholic University of Korea, Seoul, Republic of Korea.

Background: M fortuitum and M chelonae are commonly reported in surgical site infections caused by nontuberculous mycobacterium, but M septicum is rarely known. Herein, the authors report the first case of surgical site infection caused by M septicum in an immunocompetent patient after blepharoplasty.

Methods: A 37-year-old woman had persisting bilateral masses on the upper eyelids at 3 months after a blepharoplasty. Read More

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http://dx.doi.org/10.1097/SCS.0000000000006096DOI Listing
December 2019

Dissecting microbial community structure in sewage treatment plant for pathogens' detection using metagenomic sequencing technology.

Arch Microbiol 2020 May 17;202(4):825-833. Epub 2019 Dec 17.

State Key Joint Laboratory of Environment Simulation and Pollution Control, School of Environment, Tsinghua University, Beijing, 100084, People's Republic of China.

Continuous observation of wastewater treatment plants is very crucial to keep them safe for proper use and protection from pathogenic contamination. Illumina sequencing technology was used for microbiome structuring from various samples taken from different portions of the wastewater treatment plant, including influent, activated, return sludge and effluent, where different microbial compositions were found. The effluent section was found to have pathogenic microbes such as viruses, Alpha- and deltaproteobacteria, Actinobacteria, Bacteroidetes, clostridia, and bacilli in various concentrations. Read More

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http://dx.doi.org/10.1007/s00203-019-01793-yDOI Listing

Identification and molecular characterization of mycobacteria isolated from animal sources in a developing country.

Acta Trop 2020 Apr 11;204:105297. Epub 2019 Dec 11.

Department of Microbiology, School of Medicine, Isfahan University of Medical Sciences, Isfahan, Iran. Electronic address:

The essential role of animals in the transmission of infectious diseases has long been recognized. Apart from zoonosis due to Mycobacterium bovis in domestic cattle, acquired mycobacterial zoonosis from animals are vastly under-reported worldwide. This is partly the result of not recognizing that animals can be the source of zoonotic nontuberculous mycobacteria (NTM) infection. Read More

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http://dx.doi.org/10.1016/j.actatropica.2019.105297DOI Listing

Clusters of nontuberculous mycobacteria linked to water sources at three Veterans Affairs medical centers.

Infect Control Hosp Epidemiol 2020 03 11;41(3):320-330. Epub 2019 Dec 11.

Public Health Surveillance and Research, Department of Veterans Affairs, Palo Alto, California.

Objective: To characterize nontuberculous mycobacteria (NTM) associated with case clusters at 3 medical facilities.

Design: Retrospective cohort study using molecular typing of patient and water isolates.

Setting: Veterans Affairs Medical Centers (VAMCs). Read More

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http://dx.doi.org/10.1017/ice.2019.342DOI Listing

Profile of patients with pulmonary non-tuberculous mycobacterial disease mimicking pulmonary tuberculosis.

Indian J Tuberc 2019 Oct 7;66(4):461-467. Epub 2019 May 7.

Government Hospital of Thoracic Medicine, Tambaram, Chennai, India.

Introduction: With the introduction of newer molecular diagnostic tools, an increasing number of Non-tuberculous Mycobacteria (NTM) affecting the respiratory system and mimicking symptoms of pulmonary tuberculosis (PTB) are being identified. They may be misdiagnosed and treated as PTB, often categorized as treatment failures if they do not respond to treatment. This manuscript aims to characterize patients with pulmonary NTM disease. Read More

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http://dx.doi.org/10.1016/j.ijtb.2019.04.013DOI Listing
October 2019

Diagnosis and management of postlaparotomy wound infection caused by .

Int J Mycobacteriol 2019 Oct-Dec;8(4):400-402

Department of Microbiology, J. N. Medical College, KLE University, Belagavi, Karnataka, India.

Mycobacterium fortuitum is ubiquitous in nature and can cause a wide variety of lesions in humans with immunocompromised or antecedent chronic illness. Clinical diagnosis is difficult and relapses are seen. This is due to the fact that they are not critically investigated and are not responded to traditional antitubercular treatment and other antibiotics. Read More

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http://dx.doi.org/10.4103/ijmy.ijmy_93_19DOI Listing

infection and stress survival studies of acid susceptible mutant of .

Int J Mycobacteriol 2019 Oct-Dec;8(4):390-396

Department of Biotechnology and Bioinformatics, Jaypee University of Information Technology, Solan, Himachal Pradesh, India.

Background: Ubiquitous presence of Mycobacterium fortuitum and ability to cause infections in human beings, hints toward its integral resistance against environmental and host stress conditions. With an aim to identify genes responsible for adapting in vitro acidic stress of M. fortuitum, in the previous study, TnphoA random mutagenesis identified acid susceptible mutant MT727, with mutation in ribosomal maturation factor encoding gene rimP, to be mutated. Read More

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http://dx.doi.org/10.4103/ijmy.ijmy_166_19DOI Listing

Inactivation of milk-borne pathogens by blue light exposure.

J Dairy Sci 2020 Feb 20;103(2):1261-1268. Epub 2019 Nov 20.

Department of Clinical and Toxicological Analysis, School of Pharmaceutical Sciences, University of Sao Paulo, Sao Paulo, SP, Brazil, 05508-000; BioLambda, Scientific and Commercial Ltd., Sao Paulo, SP, Brazil, 05360-030. Electronic address:

Food safety and quality management play a pivotal role in the dairy industry. Milk is a highly nutritious food that also provides an excellent medium for growth of pathogenic microorganisms. Thus, dairy industry focuses most of their processes and costs on keeping contamination levels as low as possible. Read More

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http://dx.doi.org/10.3168/jds.2019-16758DOI Listing
February 2020

Drug susceptibility patterns of rapidly growing mycobacteria isolated from skin and soft tissue infections in Venezuela.

Eur J Clin Microbiol Infect Dis 2020 Mar 18;39(3):433-441. Epub 2019 Nov 18.

Departamento de Tuberculosis, Servicio Autónomo Instituto de Biomedicina "Dr. Jacinto Convit", Universidad Central de Venezuela, Caracas, Venezuela.

To our knowledge, this is the first work on drug susceptibility patterns of rapid growing mycobacteria from Latin America. The susceptibility patterns for 14 antimicrobial agents of the three most important species that cause skin infections in Venezuela were determined as follows: 63 strains belonging to Mycobacterium abscessus group, 66 strains of the Mycobacterium fortuitum group, and 13 Mycobacterium chelonae strains. The M. Read More

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http://dx.doi.org/10.1007/s10096-019-03740-7DOI Listing

Random insertion transposon mutagenesis of Mycobacterium fortuitum identified mutant defective in biofilm formation.

Biochem Biophys Res Commun 2020 01 12;521(4):991-996. Epub 2019 Nov 12.

Department of Biotechnology and Bioinformatics, Jaypee University of Information Technology, Waknaghat, Solan, 173234, H.P., India. Electronic address:

Mycobacterium fortuitum has emerged as a nosocomial infectious agent and biofilm formation attributed for the presence of this bacterium in hospital environment. Transposon random mutagenesis was used to identify membrane-proteins for biofilm formation in M. fortuitum. Read More

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http://dx.doi.org/10.1016/j.bbrc.2019.11.021DOI Listing
January 2020

Cas12a/Guide RNA-Based Platform for Rapid and Accurate Identification of Major Species.

J Clin Microbiol 2020 01 28;58(2). Epub 2020 Jan 28.

National Clinical Research Center for Infectious Diseases, Guangdong Key Laboratory of Emerging Infectious Diseases, Shenzhen Third People's Hospital, Southern University of Science and Technology, Shenzhen, China

infection and nontuberculous mycobacteria (NTM) infections exhibit similar clinical symptoms; however, the therapies for these two types of infections are different. Therefore, the rapid and accurate identification of and NTM species is very important for the control of tuberculosis and NTM infections. In the present study, a Cas12a/guide RNA (gRNA)-based platform was developed to identify and most NTM species. Read More

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http://dx.doi.org/10.1128/JCM.01368-19DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6989083PMC
January 2020

Extracellular vesicles released by J774A.1 macrophages reduce the bacterial load in macrophages and in an experimental mouse model of tuberculosis.

Int J Nanomedicine 2019 20;14:6707-6719. Epub 2019 Aug 20.

Departamento de Inmunología, Escuela Nacional de Ciencias Biológicas (ENCB), Instituto Politécnico Nacional (IPN), Mexico City, Mexico.

Background: Tuberculosis is the leading cause of death by an infectious microorganism worldwide. Conventional treatment lasts at least six months and has adverse effects; therefore, it is important to find therapeutic alternatives that reduce the bacterial load and may reduce the treatment duration. The immune response against tuberculosis can be modulated by several mechanisms, including extracellular vesicles (EVs), which are nano-sized membrane-bound structures that constitute an efficient communication mechanism among immune cells. Read More

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http://dx.doi.org/10.2147/IJN.S203507DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6708438PMC
February 2020

Culture positivity of smear negative pulmonary and extrapulmonary tuberculosis- A study from North Kerala, India.

J Family Med Prim Care 2019 Sep 30;8(9):2903-2907. Epub 2019 Sep 30.

Department of Microbiology, Government Medical College, Thrissur, Kerala, India.

Introduction: The identification of smear negative pulmonary and extrapulmonary tuberculosis continues to remain a diagnostic challenge. This study was conducted in a tertiary care setup in north Kerala to isolate and identify mycobacteria by culture from radiologically and clinically suspected cases of smear negative pulmonary and extrapulmonary tuberculosis.

Methods: A total of 200 samples (100 pulmonary and 100 extrapulmonary) were processed and cultured by automated (MB/BacT) and conventional methods. Read More

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http://dx.doi.org/10.4103/jfmpc.jfmpc_424_19DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6820437PMC
September 2019

The Chemical composition and anti-mycobacterial activities of Trachyspermum copticum and Pelargonium graveolens essential oils.

Recent Pat Antiinfect Drug Discov 2019 Oct 28. Epub 2019 Oct 28.

Department of Medical Microbiology, School of Medicine, Tehran University of Medical Sciences, Iran.

Background: Microbial resistance to antibiotics and their adverse effects related to these antibiotics are the matter of global public health in 21th century. Emergence of drug resistant strains has interested the scientists to find the new antimicrobial agents among the medicinal plant's essential oil.

Methods: Anti-mycobacterial effects of Trachyspermum copticum and Pelargonium graveolens essential oils were assessed against multi-drug resistant clinical strains of Mycobacterium tuberculosis, Mycobacterium kansasii, Mycobacterium fortuitum and standard strain of Mycobacterium tuberculosis H37Rv by a Broth micro-dilution method. Read More

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http://dx.doi.org/10.2174/1574891X14666191028113321DOI Listing
October 2019

Choroidal granuloma caused by .

Int J Retina Vitreous 2019 14;5:37. Epub 2019 Oct 14.

Hospital Federal da Lagoa, Rio de Janeiro, Brazil.

Background: To report a case of a chronic steroid user male patient who developed local abscesses caused by and concomitant asymptomatic choroidal granuloma.

Case Presentation: A 37-year-old african-american male with history of use of anabolic drugs and intramuscular mineral oil injections in the upper and lower limbs for 15 years for muscular hypertrophy. He developed intramuscular abscesses with systemic infection, sub-retinal lesions in both eyes and alterations in cerebrospinal fluid suggestive of mycobacteria. Read More

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http://dx.doi.org/10.1186/s40942-019-0185-8DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6791014PMC
October 2019
1 Read

Prevalence and molecular characterization of non-tuberculous mycobacteria in hospital soil and dust of a developing country, Iran.

Microbiology 2019 12;165(12):1306-1314

Department of Microbiology, School of Medicine, Isfahan University of Medical Sciences, Isfahan, Iran.

The presence and diversity of mycobacteria that are capable of survival in a harsh and adverse condition, such as hospital environments, have not been comprehensively studied. This study aimed to assess the frequency and diversity of mycobacteria in hospital soil and dust of a developing country using a combination of molecular and conventional methods. A total of 318 hospital dust and soil samples collected from 38 hospitals were analysed using standard protocols for characterization of mycobacteria. Read More

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http://dx.doi.org/10.1099/mic.0.000857DOI Listing
December 2019
2.557 Impact Factor

Non-pigmented rapidly growing mycobacteria smooth and rough colony phenotypes pathogenicity evaluated using in vitro and experimental models.

Pathog Dis 2019 07;77(5)

Department of Clinical Microbiology, IIS-Fundación Jiménez Díaz, UAM, 28040, Madrid, Spain.

Non-pigmented rapidly growing mycobacteria (NPRGM) are widely distributed in water, soil and animals. It has been observed an increasing importance of NPRGM related-infections, particularly due to the high antimicrobial resistance. NPRGM have rough and smooth colony phenotypes, and several studies have showed that rough colony variants are more virulent than smooth ones. Read More

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http://dx.doi.org/10.1093/femspd/ftz051DOI Listing
July 2019
7 Reads

Nontuberculous mycobacterial skin disease in cat; diagnosis and treatment - Case report.

Ann Agric Environ Med 2019 Sep 12;26(3):511-513. Epub 2019 Apr 12.

National Veterinary Research Institute, Pulawy, Poland.

Introduction: Mycobacterial diseases of humans and animals can be caused by mycobacteria other than tuberculosis (MOTT). The transmission of the infection primarily occurs via the respiratory or oral routes, but also via a damaged skin barrier. MOTT have high resistance to external factors; therefore, infected, undiagnosed animals can pose a risk for public health. Read More

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http://dx.doi.org/10.26444/aaem/101579DOI Listing
September 2019
2 Reads

Historical evolution of the diseases caused by non-pigmented rapidly growing mycobacteria in a University Hospital.

Rev Esp Quimioter 2019 Oct 19;32(5):451-457. Epub 2019 Sep 19.

Jaime Esteban, Dept. Of Clinical Microbiology. IIS-Fundación Jiménez Díaz. Av. Reyes Católicos 2. 28040-Madrid (Spain).

Objective: Non-pigmented rapidly growing mycobacteria (NPRGM) are a group of organisms of increasing interest due to the growing number of potential patients and the difficulties for a proper treatment in many of them. However, the evolution of these diseases in a long period of time and its evolutionary changes has been described only in a scanty number of reports.

Methods: We performed a retrospective study between January 1st 2004 and December 31st 2017 in order to evaluate the clinical significance and types of diseases caused by NPRGM. Read More

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http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6790884PMC
October 2019
1 Read

Nontuberculous mycobacteria isolated from specimens of pulmonary tuberculosis suspects, Northern Tunisia: 2002-2016.

BMC Infect Dis 2019 Sep 18;19(1):819. Epub 2019 Sep 18.

Unit of Typing & Genetics of Mycobacteria, Laboratory of Molecular Microbiology, Vaccinology, and Biotechnology Development, Institut Pasteur de Tunis, Université de Tunis El Manar, 13 Place Pasteur, BP74, 1002, Tunis, Tunisia.

Background: Reports on the worldwide ascending trend of pulmonary nontuberculous mycobacteria (NTM) isolation rates and their effective role in respiratory tract infections are compelling. However, as yet, there are no such data relating to Tunisia.

Methods: Here we carried out a retrospective review of mycobacterial cultures originating from Northern Tunisia, which have been processed in the laboratory of mycobacteria of the Institut Pasteur de Tunis, during the time period 2002-2016. Read More

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https://bmcinfectdis.biomedcentral.com/articles/10.1186/s128
Publisher Site
http://dx.doi.org/10.1186/s12879-019-4441-1DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6751674PMC
September 2019
2 Reads

Atypical Laryngeal Infections: Localized Lesions from Unusual Organisms May Simulate Malignancy.

Ann Otol Rhinol Laryngol 2020 Jan 14;129(1):82-86. Epub 2019 Sep 14.

Department of Surgery, Division of Otolaryngology-Head and Neck Surgery, NorthShore University HealthSystem, Evanston, IL, USA.

Objective: The identification of rare sources of laryngeal infection in immunocompetent patients. Recovered organisms were (laryngeal tuberculosis [LTB]), (laryngeal [LMF]), and (laryngeal blastomycosis [LB]).

Method: Single institution retrospective case series of three patients over a 2. Read More

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http://dx.doi.org/10.1177/0003489419875755DOI Listing
January 2020
3 Reads

Prevalence and risk factors of pulmonary nontuberculous mycobacterial infections in the Zhejiang Province of China.

Epidemiol Infect 2019 09 11;147:e269. Epub 2019 Sep 11.

National Clinical Laboratory on Tuberculosis, Beijing Chest Hospital affiliated to Capital Medical University, Beijing Tuberculosis & Thoracic Tumor Research Institute, Beijing, 101149, P.R.China.

Risk factors and prevalence of pulmonary nontuberculous mycobacterial (NTM) diseases were retrospectively evaluated in 1208 suspected pulmonary TB patients seeking care at the Affiliated Hospital of Hangzhou Normal University between July 2018 and December 2018. Further analysis of 390 culture-positive cases demonstrated that 358 (358/390, 91.8%) were infected with Mycobacterium tuberculosis (MTB), 24 (24/390, 6. Read More

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http://dx.doi.org/10.1017/S0950268819001626DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6807301PMC
September 2019
3 Reads
2.535 Impact Factor

Hypercalcaemia secondary to disseminated Mycobacterium abscessus and Mycobacterium fortuitum.

J R Coll Physicians Edinb 2019 09;49(3):217-221

Internal Medicine, Woodlands Health Campus, Yishun, Singapore.

The incidence and prevalence of nontuberculous mycobacteria (NTM) infection is on the rise with many cases still going unreported. Given the vague and nonspecific clinical features of NTM infections, it is often missed or mistaken for Mycobacterium tuberculosis. The presumption that NTM infections are benign and do not contribute to morbidity no longer holds true. Read More

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https://www.rcpe.ac.uk/college/journal/hypercalcaemia-second
Publisher Site
http://dx.doi.org/10.4997/JRCPE.2019.309DOI Listing
September 2019
18 Reads