1,514 results match your criteria Mycobacterium Chelonae


Quantification of members of the Mycobacterium chelonae-abscessus complex in lesions of the endangered houston toad (Anaxyrus houstonensis).

Syst Appl Microbiol 2022 Jun 16;45(4):126342. Epub 2022 Jun 16.

Texas State University, Department of Biology, 601 University Drive, San Marcos, TX, 78666, United States. Electronic address:

Illumina-based 16S rRNA V3 amplicon sequencing of total DNA obtained from soft tissue lesions (joint granulomas) of the endangered Houston toad (Anaxyrus houstonensis) demonstrated that many reads represented members of the actinobacterial Mycobacterium chelonae-abscessus complex. In order to quantify members of this complex in those lesions, we designed three complex-specific primer set/probe combinations (sets I, II and III) targeting variable regions on the 23S rRNA gene for SybrGreen- and Taqman-based quantitative polymerase chain reaction (qPCR). Both SybrGreen- and Taqman-based analyses specifically detected members of the M. Read More

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Periocular non-tuberculous mycobacterial infection after autologous fat transfer with micro-needling and fractional radiofrequency skin resurfacing.

Orbit 2022 Jun 24:1-3. Epub 2022 Jun 24.

Consultants in Ophthalmic and Facial Plastic Surgery, P.C, Southfield, MI, USA.

A 59-year-old woman with prior bilateral lower eyelid autologous fat transfer, subdermal micro-needling and fractional radiofrequency skin resurfacing presented with delayed left-sided preseptal cellulitis with small multinodular abscesses unresponsive to oral outpatient antibiotic regimens and inpatient intravenous antibiotics. Wound culture revealed infection treated successfully with a 4-month regimen of clarithromycin and tedizolid without recurrence. This case highlights (1) the need for vigilance and a broad differential in delayed post-operative wound infections including non-tuberculous mycobacterial infections, (2) resolution of infection without recurrence on clarithromycin and novel tedizolid oral antibiotic therapy, and (3) that caution should be exercised when performing combination autologous fat transfers with subdermal micro-needling procedures as the breakdown in skin integrity may potentiate infection. Read More

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A novel therapeutic strategy to close bronchopleural fistula related to in elderly patients: two case reports and literature review.

Ann Transl Med 2022 May;10(10):615

Second Department of Geriatrics Respiratory Medicine, Guangdong Provincial People's Hospital, Guangdong Academy of Medical Sciences, Guangdong Provincial Geriatrics Institute, Guangzhou, China.

Background: () empyema complicated with bronchopleural fistula (BPF) remains a significant challenge in diagnosis and treatment and the clinical outcomes are often unsatisfactory, especially in elderly patients. There is a paucity data related to the management of the condition. This is the first well-documented report of the therapeutic experience with bronchoscopic closure of a bronchopleural fistula with empyema related to infection in the elderly patients. Read More

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Isolation of potential zoonotic Mycobacterium spp. from diseased freshwater angelfish (Pterophyllum scalare) from an aquarium.

Braz J Biol 2022 6;84:e262851. Epub 2022 Jun 6.

Universidade de São Paulo, Departamento de Medicina Veterinária Preventiva e Saúde Animal, São Paulo, SP, Brasil.

Nontuberculous mycobacteria infection is one of the most common chronic bacterial diseases in ornamental aquarium fish and appears to be directly related to stressful husbandry practices. Furthermore, it also represents zoonotic potential. Here we present the isolation and characterization of non-tuberculous mycobacteria from diseased freshwater angelfish (Pterophyllum scalare) in São Paulo, Brazil. Read More

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Post Surgical Non-tuberculous Mycobacterium: A Case Series.

Cureus 2022 May 3;14(5):e24701. Epub 2022 May 3.

Department of Medicine, Government Medical College, Aurangabad, IND.

Background There has been an increase in non-tuberculous mycobacteria (NTM) infection reports in humans. Surgeons are concerned about the link between them and surgical site infections. As a result, it has been challenging to determine just how common this illness is. Read More

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Prosthetic joint infection of the hip and knee due to : A systematic review.

World J Orthop 2022 May 18;13(5):503-514. Epub 2022 May 18.

Nicolaas Institute of Constructive Orthopaedic Research and Education Foundation at Medistra Hospital, Jakarta 12950, Indonesia.

Background: () is an emerging cause of hip and knee prosthetic joint infection (PJI), and different species of this organism may be responsible for the same.

Aim: To evaluate the profile of hip and knee PJI cases as published in the past 30 years.

Methods: A literature search was performed in PubMed using the MeSH terms "Prosthesis joint infection" AND "Mycobacterium" for studies with publication dates from January 1, 1990, to May 30, 2021. Read More

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Antibiotic Susceptibility of Mycobacteria Isolated from Ornamental Fish.

J Vet Res 2022 Mar 25;66(1):69-76. Epub 2022 Mar 25.

Department of Biology and Fish Diseases, Faculty of Veterinary Medicine, University of Life Sciences, Lublin, Poland.

Introduction: Nontuberculous mycobacteria (NTM) are increasingly recognised as causative agents of opportunistic infections in humans for which effective treatment is challenging. There is very little information on the prevalence of NTM drug resistance in Poland. This study was aimed to evaluate the susceptibility to antibiotics of NTM, originally isolated from diseased ornamental fish. Read More

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GenoType CM Direct and VisionArray Myco for the Rapid Identification of Mycobacteria from Clinical Specimens.

J Clin Med 2022 Apr 25;11(9). Epub 2022 Apr 25.

Institute of Medical Microbiology, University Hospital Essen, University of Duisburg-Essen, 45147 Essen, Germany.

is the single infectious agent responsible for most deaths worldwide outside of pandemics. Diseases due to non-tuberculous mycobacteria (NTM) are increasing in many regions of the world. The two molecular assays GenoType CM direct (GTCMd) (Bruker, Billerica, MA, USA) and VisionArray Myco (VAM) (ZytoVision, Bremerhaven, Germany) are based on the DNA/DNA hybridization technique, and allow for the identification of tuberculous and the most clinically relevant non-tuberculous mycobacterial species from clinical specimens. Read More

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Bacteriophage treatment of disseminated cutaneous Mycobacterium chelonae infection.

Nat Commun 2022 05 3;13(1):2313. Epub 2022 May 3.

Department of Biological Sciences, University of Pittsburgh, Pittsburgh, PA, USA.

Mycobacterium chelonae is a rare cause of chronic disseminated cutaneous infections in immunocompromised patients. Multidrug-resistant M. chelonae infections present a challenge for treatment, and prolonged antimicrobial courses lead to significant toxicities and further antimicrobial resistance. Read More

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Case of Moxifloxacin-Induced Black Hairy Tongue.

Am J Case Rep 2022 Apr 25;23:e936235. Epub 2022 Apr 25.

Department of Infectious Diseases, University of Tsukuba Hospital, Tsukuba, Ibaraki, Japan.

BACKGROUND Black hairy tongue (BHT) is a relatively uncommon acquired benign condition, with a prevalence ranging from 0.6% to 11.3%. Read More

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Desiccation-Tolerance of , , , and .

Pathogens 2022 Apr 13;11(4). Epub 2022 Apr 13.

Department of Biological Sciences, Virginia Tech, Blacksburg, VA 24061, USA.

Desiccation-tolerance of cells of four strains of and individual strains of , , , and were measured by two methods. The survival of water-acclimated cells both in filter paper and on the surface of stainless-steel coupons were measured. In filter paper at 40% relative humidity at 25 °C, survival of patient isolates of and cells was 28% and 34% after 21 days of incubation, whereas it was 100% for the Sorin 3T isolate of . Read More

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Spondylodiscitis secondary to : a case report.

J Spine Surg 2022 Mar;8(1):62-69

Department of Pathology, University of Toledo Medical Center, Toledo, Ohio, USA.

Background: Spondylodiscitis secondary to () is a rare primary infection of the spine, with a few case reports highlighted. Treatment of this infection is not well established but here we discuss a case where a patient recovered well following early aggressive surgical intervention and antibiotic treatment.

Case Description: A 32-year-old male presented with a 3-month history of worsening low back pain, Horner's syndrome, dysphagia, lower extremity weakness, and a 5-day history of bowel and bladder incontinence. Read More

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Eravacycline infusion-related hypoesthesia: A case report.

Am J Health Syst Pharm 2022 Apr 4. Epub 2022 Apr 4.

University of South Carolina College of Pharmacy, Columbia, SC, and Department of Pharmacy, Prisma Health Midlands, Columbia, SC, USA.

Disclaimer: In an effort to expedite the publication of articles, AJHP is posting manuscripts online as soon as possible after acceptance. Accepted manuscripts have been peer-reviewed and copyedited, but are posted online before technical formatting and author proofing. These manuscripts are not the final version of record and will be replaced with the final article (formatted per AJHP style and proofed by the authors) at a later time. Read More

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Infectious eccrine hidradenitis: sweat glands as the portal of entry for cellulitis.

BMJ Case Rep 2022 Apr 4;15(4). Epub 2022 Apr 4.

Department of Dermatology, Westmead Hospital, Westmead, New South Wales, Australia.

Neutrophilic eccrine hidradenitis (NEH) is a rare neutrophilic dermatosis involving the eccrine glands. It is commonly associated with haematological malignancy and administration of chemotherapy. An infective aetiology for NEH is termed infectious eccrine hidradenitis (IEH). Read More

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Rapid and Accurate Differentiation of Complex Species by Liquid Chromatography-Ultra-High-Resolution Orbitrap™ Mass Spectrometry.

Front Cell Infect Microbiol 2022 9;12:809348. Epub 2022 Mar 9.

ARUP Institute for Clinical and Experimental Pathology, Salt Lake City, UT, United States.

In this study, a Liquid Chromatography-Mass Spectrometry (LC-MS) method for the identification of clinically relevant () complex organisms is tested using a set of microbial Type strains. This methodology is based on profiling proteins derived from complex isolates. These protein profiles are then used as markers of species differentiation. Read More

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Mycobacterium chelonae infection in an immunocompromised patient presenting as multiple papulonodules on the leg.

Acta Dermatovenerol Alp Pannonica Adriat 2022 03;31(Suppl):S21-S24

Department of Dermatovenereology, Ljubljana University Medical Centre, Ljubljana, Slovenia.

Mycobacterium chelonae is a rapidly growing nontuberculous mycobacteria that is a rare cause of cutaneous infections in both immunocompromised and immunocompetent patients. The clinical presentation is heterogeneous and non-specific, and therefore, despite an increasing incidence of these infections, patients are often misdiagnosed. Here we present the case of an immunocompromised 73-year-old female patient that developed tender, erythematous, violaceous to brownish papules and nodules on both the anterior and posterior aspects of her left lower leg. Read More

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Late-Onset Nontuberculous Mycobacterial Keratitis After Small Incision Lenticule Extraction.

Cornea 2021 Oct 20. Epub 2021 Oct 20.

Department of Ophthalmology and Visual Sciences, The Chinese University of Hong Kong, Hong Kong.

Purpose: The purpose of this article was to report a case of unilateral late-onset nontuberculous mycobacterial keratitis after small incision lenticule extraction (SMILE).

Methods: This was a case report.

Results: A 27-year-old woman presented with Mycobacterium chelonae keratitis 3 weeks after uncomplicated SMILE with a solitary interface infiltrate. Read More

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October 2021

Answer to March 2022 Photo Quiz.

J Clin Microbiol 2022 03 16;60(3):e0098021. Epub 2022 Mar 16.

Department of Pathology and Laboratory Medicine, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA, USA.

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Identification and characterization of nontuberculous mycobacteria isolated from suspected pulmonary tuberculosis patients in eastern china from 2009 to 2019 using an identification array system.

Braz J Infect Dis 2022 Mar-Apr;26(2):102346. Epub 2022 Mar 11.

Department of Infectious Diseases, Shanghai Key Laboratory of Infectious Diseases and Biosafety Emergency Response, National Medical Center for Infectious Diseases, Huashan Hospital, Fudan University, Shanghai, China. Electronic address:

Objective: Nontuberculous mycobacteria (NTM) species are increasingly being isolated and have become a key factor affecting public health by causing pulmonary diseases. Most NTM species do not respond to conventional tuberculosis (TB) drugs. This study aimed to identify NTM isolated from suspected pulmonary TB patients from the Zhejiang province and analyze their distribution in the region. Read More

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Nontuberculous Mycobacteria in Portugal: Trends from the last decade.

Pulmonology 2022 Feb 23. Epub 2022 Feb 23.

National Reference Laboratory for Mycobacteria, Dept of Infectious Diseases, National Institute of Health, Lisbon, Portugal. Electronic address:

Introduction And Objectives: Nontuberculous mycobacteria (NTM) are opportunistic human pathogens found in the environment. The transmission seems to be associated with inhalation of aerosol droplets, ingestion or trauma events. Recent studies indicate that NTM disease is increasing worldwide, however, the true clinical impact of NTM infections is difficult to determine due to challenges in discriminating between disease and colonization as they are ubiquitous in the environment. Read More

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February 2022

A rare case of Mycobacterium Chelonae infection in an immunocompromised adult with cavernous sinus syndrome.

CNS Neurosci Ther 2022 05 15;28(5):796-799. Epub 2022 Feb 15.

Department of Neurology, Xiangya Hospital, Central South University, Changsha, China.

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Disseminated Mycobacterium chelonae infection in a heart transplant recipient.

IDCases 2022 25;27:e01424. Epub 2022 Jan 25.

Division of Geographic Medicine and Infectious Diseases, Tufts Medical Center, Boston, MA, USA.

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January 2022

Review of Early Signs of Breast Implant Infection.

Aesthetic Plast Surg 2022 Jan 29. Epub 2022 Jan 29.

Plastic Surgery Division, Department of Surgery, John A. Burns School of Medicine, University of Hawaii, 1329 Lusitana Street, Suite 807, Honolulu, Hawaii, 96813, USA.

Background: Breast implant infection remains a problem despite various prevention methods. Common pathogens such as staphylococcus aureus typically present acutely with fever, erythema, swelling, and pain. However, with the increasing occurrence of mycobacterial infections, associated early signs and symptoms are typically absent, making early detection difficult. Read More

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January 2022

Consensus management recommendations for less common non-tuberculous mycobacterial pulmonary diseases.

Lancet Infect Dis 2022 Jul 25;22(7):e178-e190. Epub 2022 Jan 25.

National Jewish Health and University of Colorado Health Sciences, Denver, CO, USA.

The 2020 clinical practice guideline for the treatment of non-tuberculous mycobacterial pulmonary disease (NTM-PD) by the American Thoracic Society, European Respiratory Society, European Society of Clinical Microbiology and Infectious Diseases, and Infectious Diseases Society of America; and the 2017 management guideline by the British Thoracic Society covered pulmonary diseases in adults caused by Mycobacterium avium complex, Mycobacterium kansasii, Mycobacterium xenopi, and Mycobacterium abscessus. In order to provide evidence-based recommendations for the treatment of less common non-tuberculous mycobacterial (NTM) species in adult patients without cystic fibrosis or HIV infection, our expert panel group performed systematic literature searches to provide management guidance for pulmonary diseases caused by seven additional organisms: Mycobacterium chelonae, Mycobacterium fortuitum, Mycobacterium genavense, Mycobacterium gordonae, Mycobacterium malmoense, Mycobacterium simiae, and Mycobacterium szulgai. Treatment recommendations were developed by a structured consensus process. Read More

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Atypical mycobacterium infection following upper eyelid Müller's muscle-conjunctival resection - case report.

Orbit 2022 Jan 24:1-4. Epub 2022 Jan 24.

Department of Ophthalmology, Hong Kong Eye Hospital, Hong Kong, China.

Periorbital non-tuberculous mycobacterium (NTM) infections are uncommon. To the best of our knowledge, NTM infection as a complication following Müller's muscle-conjunctival resection (MMCR) surgery has not been reported before. We report a case of left upper lid infection following MMCR surgery. Read More

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January 2022

Infection Identified by Metagenomic Next-Generation Sequencing as the Probable Cause of Acute Contained Rupture of a Biological Composite Graft-A Case Report.

Int J Mol Sci 2021 Dec 29;23(1). Epub 2021 Dec 29.

Genomic Research Laboratory, Geneva University Hospitals, University of Geneva, 1206 Geneva, Switzerland.

We present the case of a 72-year-old female patient with acute contained rupture of a biological composite graft, 21 months after replacement of the aortic valve and the ascending aorta due to an aortic dissection. Auramine-rhodamine staining of intraoperative biopsies showed acid-fast bacilli, but classical culture and molecular methods failed to identify any organism. Metagenomic analysis indicated infection with  , which was confirmed by target-specific qPCR. Read More

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December 2021

Chemical susceptibility testing of non-tuberculous mycobacterium strains and other aquatic bacteria: Results of a study for the development of a more sensitive and simple method for the detection of NTM in environmental samples.

J Microbiol Methods 2022 02 3;193:106405. Epub 2022 Jan 3.

Department of Public Health and Pediatrics, University of Turin, Italy.

The methods employed to detect non-tuberculous mycobacteria on environmental samples are essentially those classically used in clinical microbiology, which envisage a decontamination step to reduce the overgrowth of non-mycobacterial organisms before plating them on the culture medium. The aim of this study was to propose alternative culture techniques to improve non-tuberculous mycobacteria detection in environmental samples. We used artificially contaminated samples to compare the membrane filter washing procedure against direct plating of membrane filters on culture media in relation to M. Read More

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February 2022

Disseminated Mycobacterium chelonae Infection, Including Discitis.

Intern Med 2021 Dec 18. Epub 2021 Dec 18.

Department of Infection Prevention and Control, Tokyo Medical University Hospital, Japan.

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December 2021

Cutaneous infection presenting clinically as a mycetoma.

JAAD Case Rep 2022 Jan 16;19:54-57. Epub 2021 Nov 16.

Department of Dermatology, University of Florida Health, Gainesville, Florida.

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January 2022

Cutaneous Infection: A Challenge for an Internist.

Eur J Case Rep Intern Med 2021 15;8(11):003013. Epub 2021 Nov 15.

Department of Internal Medicine, Hospital Distrital da Figueira da Foz, EPE, Figueira da Foz, Portugal.

Cutaneous infections caused by the complex show a heterogeneous clinical presentation, which varies according to the patient's immune status. Most standard antimycobacterials have no effect against these species. Clarithromycin alone was shown to provide adequate treatment, although resistance has been reported. Read More

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November 2021