3,568 results match your criteria Mycobacterium Avium-Intracellulare Infection


Optimization of In Vitro and Growth Assays for Therapeutic Development.

Microorganisms 2019 Feb 1;7(2). Epub 2019 Feb 1.

Division of Pulmonology, Allergy and Immunology, Department of Pediatrics, Case Western Reserve University School of Medicine, 10900 Euclid Ave. BRB 822, Cleveland, OH 44106, USA.

Infection with nontuberculous mycobacteria (NTM) is a complication of lung disease in immunocompromised patients, including those with human immunodeficiency virus and acquired immune deficiency syndrome (HIV/AIDS), chronic obstructive pulmonary disease (COPD), and cystic fibrosis (CF). The most widespread, disease-causing NTM is complex (), which colonizes the lungs as a combination of , , and other mycobacterial species. While combination drug therapy exists for colonization, there is no cure. Read More

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http://dx.doi.org/10.3390/microorganisms7020042DOI Listing
February 2019
1 Read

Genitourinary Tract Infection Due to Mycobacterium avium intracellulare Complex Infection in Pretransplant Setting With Recurrence Following Transplant: A Case Report.

Transplant Proc 2018 Dec 8;50(10):3937-3939. Epub 2018 Sep 8.

Program in Adult Transplant Infectious Disease, Division of Infectious Disease and International Medicine, Department of Medicine, University of Minnesota, Minneapolis, Minnesota.

Genitourinary (GU) tract infection with Mycobacterium avium intracellulare complex (MAI) is very rare and, to our knowledge, has never been reported in the solid organ transplant literature. CASE DESCRIPTION: A 61-year-old Somali-born woman had a history of liver cirrhosis due to chronic hepatitis C infection. She was diagnosed as having and treated for latent tuberculosis infection and GU tract infection due to MAI. Read More

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https://linkinghub.elsevier.com/retrieve/pii/S00411345183116
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http://dx.doi.org/10.1016/j.transproceed.2018.09.007DOI Listing
December 2018
12 Reads

[Hypersensitivity pneumonitis and abscess reaction to nontuberculous mycobacteria acquired form jacuzzi aerosol].

Rev Mal Respir 2019 Jan 17;36(1):57-62. Epub 2018 Dec 17.

Université François Rabelais, Inserm U1100, faculté de médecine de Tours, 37000 Tours, France.

Introduction: Mycobacterium avium complex can be responsible for a number of different radio-clinical presentations, ranging from invasive infections to hypersensitivity pneumonitis due to repeated inhalation of antigens. The diagnosis of hypersensitivity pneumonitis is clinical, radiological, biological and microbiological.

Case Report: A 61-year-old male developed a hypersensitivity pneumonitis reaction to non-tuberculous mycobacteria, following the repeated use of his own spa, which later evolved into chronic respiratory failure. Read More

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http://dx.doi.org/10.1016/j.rmr.2017.10.670DOI Listing
January 2019
1 Read

Mycobacterium avium complex infection in patients with human immunodeficiency virus: A systematic review and meta-analysis.

J Cell Physiol 2018 Dec 12. Epub 2018 Dec 12.

Department of Microbiology, School of Medicine, Iran University of Medical Sciences, Tehran, Iran.

Background: Mycobacterium avium-intracellulare complex (MAC) is one of the leading causes of death among people living with human immunodeficiency virus (HIV). The current study was aimed to determine the frequency of MAC infection in patients infected with HIV.

Methods: Embase, PubMed, and Web of Science were searched for relevant studies. Read More

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http://dx.doi.org/10.1002/jcp.27859DOI Listing
December 2018

When occam's razor can fail- active mycobacteria infection and lung cancer: A case of neuroendocrine lung cancer diagnosed in the setting of refractory mycobacterium avium-intracellulare.

Clin Case Rep 2018 Nov 27;6(11):2156-2159. Epub 2018 Sep 27.

Department of Medicine Madigan Army Medical Center Tacoma Washington.

The link between Myobacterium avium-intracellulare and lung cancer remains underemphasized in literature. Our objective is to increase awareness of Myobacterium avium-intracellulare and coexisting lung cancer and to emphasize the need in establishing prevalence and specific testing guidelines in this patient population. Read More

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http://dx.doi.org/10.1002/ccr3.1813DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6230639PMC
November 2018

Cutaneous Mycobacterial Infections.

Clin Microbiol Rev 2018 01 14;32(1). Epub 2018 Nov 14.

Servicio de Dermatología y Departamento de Micología, Hospital General de México, Mexico City, Mexico.

Humans encounter mycobacterial species due to their ubiquity in different environmental niches. In many individuals, pathogenic mycobacterial species may breach our first-line barrier defenses of the innate immune system and modulate the activation of phagocytes to cause disease of the respiratory tract or the skin and soft tissues, sometimes resulting in disseminated infection. Cutaneous mycobacterial infections may cause a wide range of clinical manifestations, which are divided into four main disease categories: (i) cutaneous manifestations of infection, (ii) Buruli ulcer caused by and other related slowly growing mycobacteria, (iii) leprosy caused by and , and (iv) cutaneous infections caused by rapidly growing mycobacteria. Read More

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http://dx.doi.org/10.1128/CMR.00069-18DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6302357PMC
January 2018
4 Reads

Esophageal Mycobacterium avium-intracellulare infection in a bone marrow transplant patient: Case report and literature review.

Transpl Infect Dis 2019 Feb 19;21(1):e13019. Epub 2018 Nov 19.

Department of Internal Medicine, Saint Louis University, Saint Louis, Missouri.

Mycobacterium avium-intracellulare complex (MAC) is the most common cause of nontuberculous mycobacterial (NTM) disease in humans. We report a case of esophageal MAC disease in a patient who had allogeneic bone marrow transplant for acute lymphoblastic leukemia. Although pulmonary MAC in immunocompromised host is not uncommon, there are only a few cases of NTM-associated esophageal mass reported. Read More

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http://doi.wiley.com/10.1111/tid.13019
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http://dx.doi.org/10.1111/tid.13019DOI Listing
February 2019
15 Reads

Association between Mycobacterium avium complex lung disease and serum vitamin D status, antimicrobial peptide levels, and bone mineral density.

Medicine (Baltimore) 2018 Sep;97(38):e12463

Department of Respiratory Medicine, Graduate School of Medicine, Kyoto University, Kyoto, Japan.

Vitamin D maintains calcium balance and has immunomodulatory effects. Only few studies have revealed the relationship between vitamin D and its associated factors in Mycobacterium avium complex (MAC) infection. This study aimed to investigate the effects of MAC infection on serum vitamin D, human cationic antimicrobial protein 18, its C-terminal 37 amino acid fragment (hCAP18/LL-37) levels, and bone mineral density (BMD). Read More

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http://dx.doi.org/10.1097/MD.0000000000012463DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6160122PMC
September 2018
2 Reads

The cost of Mycobacterium avium complex lung disease in Canada, France, Germany, and the United Kingdom: a nationally representative observational study.

BMC Health Serv Res 2018 Sep 10;18(1):700. Epub 2018 Sep 10.

Institute for Epidemiology, University Medical Hospital Schleswig-Holstein (Member of the German Center for Lung Research [ARCN]), Kiel, Germany.

Background: Management of nontuberculous mycobacterial lung disease (NTMLD) consists of a long-term multi-drug antibiotic regimen, yet many patients do not achieve culture conversion. We estimated the NTMLD-related direct medical costs in Canada, France, Germany, and the United Kingdom (UK) among refractory patients who were infected with Mycobacterium avium complex (MAC), without concomitant cystic fibrosis, tuberculosis, or HIV.

Methods: We conducted a retrospective observational physician survey of nationally representative samples. Read More

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http://dx.doi.org/10.1186/s12913-018-3489-8DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6131733PMC
September 2018
1 Read

Fast update of undetected Mycobacterium chimaera infections to reveal unsuspected cases.

J Hosp Infect 2018 Dec 1;100(4):451-455. Epub 2018 Sep 1.

Instituto de Investigación Sanitaria Gregorio Marañón, Madrid, Spain; Hospital General Universitario Gregorio Marañón, Servicio de Microbiología, Madrid, Spain; CIBERES (CB06/06/0058), CIBER Enfermedades Respiratorias, Spain. Electronic address:

Mycobacterium chimaera is involved in a worldwide alert due to contaminated heater-cooler units. A real-time polymerase chain reaction (RT-PCR)-based procedure was implemented to survey undetected cases of M. chimaera infection. Read More

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http://dx.doi.org/10.1016/j.jhin.2018.08.018DOI Listing
December 2018
14 Reads

Adjuvant lung resection in the management of nontuberculous mycobacterial lung infection: A retrospective matched cohort study.

Respir Med 2018 09 9;142:1-6. Epub 2018 Jul 9.

Division of Respirology, Department of Medicine, University Health Network, Toronto Western Hospital, 399 Bathurst Street, Toronto, ON, M5T 2S8, Canada; Department of Medicine, University of Toronto, 27 King's College Circle, Toronto, ON, M5S 1A1, Canada. Electronic address:

Background And Objectives: Lung resection in patients with nontuberculous mycobacterial pulmonary disease (NTM-PD) is considered when medical therapy alone fails to provide long term control. Data regarding comparative and long-term outcomes are limited. We aimed to review indications and outcomes of adjuvant lung resection for NTM-PD compared with controls. Read More

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http://dx.doi.org/10.1016/j.rmed.2018.07.003DOI Listing
September 2018
3 Reads

Therapeutic implications of nano-encapsulated rifabutin, azithromycin & ethambutol against experimental infection in mice.

Indian J Med Res 2018 06;147(6):594-602

Department of Biochemistry, Postgraduate Institute of Medical Education & Research, Chandigarh, India.

Background & Objectives: Mycobacterium avium causes atypical infection in both immunocompetent and immunocompromised individuals. Conventional chemotherapy for M. avium infection is not efficient due to lengthy course of treatment and drug-associated toxic side effects. Read More

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http://www.ijmr.org.in/text.asp?2018/147/6/594/239930
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http://dx.doi.org/10.4103/ijmr.IJMR_2004_15DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6118139PMC
June 2018
14 Reads
1.660 Impact Factor

Nontuberculous Mycobacterial Lung Diseases Caused by Mixed Infection with Mycobacterium avium Complex and Mycobacterium abscessus Complex.

Antimicrob Agents Chemother 2018 Oct 24;62(10). Epub 2018 Sep 24.

Division of Pulmonary and Critical Care Medicine, Department of Medicine, Samsung Medical Center, Sungkyunkwan University School of Medicine, Seoul, South Korea

complex (MAC) and complex (MABC) comprise the two most important human pathogen groups causing nontuberculous mycobacterial lung disease (NTM-LD). However, there are limited data regarding NTM-LD caused by mixed NTM infections. This study aimed to evaluate the clinical characteristics and treatment outcomes in patients with NTM-LD caused by mixed infection with these two major NTM pathogen groups. Read More

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http://aac.asm.org/lookup/doi/10.1128/AAC.01105-18
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http://dx.doi.org/10.1128/AAC.01105-18DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6153851PMC
October 2018
9 Reads

Evaluation of six decontamination procedures for isolation of Mycobacterium avium complex from avian feces.

PLoS One 2018 10;13(8):e0202034. Epub 2018 Aug 10.

Department of Electrical and Computer Engineering, University of Alberta, Edmonton, Canada.

Culture is considered the gold standard for definitive diagnosis of mycobacterial infections. However, consensus about the most suitable culture procedure for isolation of nontuberculous mycobacteria is lacking. The study compared the recoveries of mycobacteria after decontamination of spiked and fresh avian feces with 4% sodium hydroxide (NaOH), 12% sulfuric acid (H2SO4), or 1% cetylperidinium chloride (CPC), with and without mixture of three antibiotics, namely vancomycin (VAN, 100 μg/ml), nalidixic acid (NAL, 100 μg/ml), and amphotericin B (AMB, 100 μg/ml). Read More

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http://journals.plos.org/plosone/article?id=10.1371/journal.pone.0202034PLOS
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6086441PMC
February 2019
3 Reads

Characteristics of patients with bronchoscopy-diagnosed pulmonary Mycobacterium avium complex infection.

J Infect Chemother 2018 Oct 25;24(10):822-827. Epub 2018 Jul 25.

Department of Respiratory Medicine, Toho University Omori Medical Center, 6-11-1 Omori-nishi, Otaku, Tokyo, 143-8540, Japan.

Background: We occasionally treat patients with clinically suspected pulmonary Mycobacterium avium complex (MAC) infection and negative MAC culture on bronchoscopy.

Objective: This study aimed to investigate the usefulness of bronchoscopy in patients with suspected MAC lung disease with nodular bronchiectasis on chest computed tomography (CT) and to clarify the clinical characteristics of these patients.

Methods: We reviewed the records of 71 patients with clinically suspected pulmonary MAC infection on chest CT who underwent bronchoscopy. Read More

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http://dx.doi.org/10.1016/j.jiac.2018.06.014DOI Listing
October 2018
4 Reads

Mycobacterium avium complex bacteria remain viable in sputum during storage and refrigeration.

Diagn Microbiol Infect Dis 2018 Dec 27;92(4):309-310. Epub 2018 Jun 27.

Department of Medical Microbiology, Radboud University Medical Center, PO Box 9101, 6500, HB, Nijmegen, the Netherlands.

Diagnostic mycobacteriology often involves shipping of samples to centralized laboratories. Using two quantitative culture techniques, we show that 7 days storage of sputum samples at room temperature or 4 °C does not affect the number of viable Mycobacterium avium complex bacteria. Storage at room temperature increases the chance of contamination. Read More

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http://dx.doi.org/10.1016/j.diagmicrobio.2018.06.017DOI Listing
December 2018
5 Reads
2.460 Impact Factor

Mycobacterium avium complex infection in pigs: A review.

Comp Immunol Microbiol Infect Dis 2018 Apr 14;57:62-68. Epub 2018 Jun 14.

Veterinary Research Institute, Hudcova 70, 621 00 Brno, Czech Republic. Electronic address:

Mycobacterial infections in pigs are caused particularly by the Mycobacterium avium complex (MAC) and these infections lead to great economic losses mainly within the countries with high pork meat production. The importance of the MAC infections in humans is rising because of its higher prevalence and also higher mortality rates particularly in advanced countries. In addition, treatment of the MAC infections in humans tends to be complicated because of its increasing resistance to antimicrobial agents. Read More

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http://dx.doi.org/10.1016/j.cimid.2018.06.005DOI Listing
April 2018
4 Reads

Mycobacterial chylous ascites: report of three cases and systematic review.

Ther Adv Infect Dis 2018 Jul 2;5(4):69-75. Epub 2018 May 2.

Department of Gastroenterology, Postgraduate Institute of Medical Education and Research, Chandigarh, India.

Background: Chylous ascites is an uncommon presentation of mycobacterial infection.

Methods: We report three cases of tubercular chylous ascites, and in addition, we performed a systematic review of the published literature for the clinical presentation, treatment, and outcomes of mycobacterial chylous ascites. We followed the PRISMA guidelines for the systematic review. Read More

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http://dx.doi.org/10.1177/2049936118772754DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6044110PMC
July 2018
20 Reads

[Antimicrobial susceptibility and genotyping of ].

Zhonghua Jie He He Hu Xi Za Zhi 2018 Jul;41(7):539-543

National Clinical Laboratory on Tuberculosis, Beijing Key Laboratory for Drug Resistant Tuberculosis Research, Beijing Chest Hospital, Capital Medical University, Beijing Tuberculosis and Thoracic Tumor Institute, Beijing 101149, China.

To investigate the antimicrobial susceptibility and genotyping of . A total of 150 . isolates were collected. Read More

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http://dx.doi.org/10.3760/cma.j.issn.1001-0939.2018.07.007DOI Listing

Endobronchial Non-Tuberculosis Mycobacterium Infection Presenting in a Healthy Child.

Ann Otol Rhinol Laryngol 2018 Oct 2;127(10):726-730. Epub 2018 Jul 2.

2 Department of Otolaryngology, Children's Mercy Hospital, Kansas City, Missouri, USA.

Objectives: To describe a safe and effective treatment for endobronchial Mycobacterium avium complex.

Methods: Case report and literature review.

Results: We present a case of endobronchial M. Read More

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http://dx.doi.org/10.1177/0003489418784970DOI Listing
October 2018
3 Reads

Tenosynovitis with Rice Body Formation Due to Mycobacterium Intracellulare Infection After Initiation of Infliximab Therapy.

Am J Case Rep 2018 Jun 7;19:656-662. Epub 2018 Jun 7.

Department of Respiratory Medicine, Kyorin University School of Medicine, Mitaka, Tokyo, Japan.

BACKGROUND Rheumatoid arthritis tenosynovitis is difficult to discriminate from non-tuberculous tenosynovitis on the basis of radiological and pathological findings. CASE REPORT A 74-year-old woman with a 4-year history of rheumatoid arthritis was referred to our hospital to undergo treatment for uncontrollable tenderness and swelling in her right third metacarpophalangeal joint, right wrist, and left knee joint. In the previous year, she underwent surgery at a local hospital for the swelling in her right metacarpophalangeal joint, the information of which was not known precisely, but the swelling subsided in due course after an operation. Read More

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http://dx.doi.org/10.12659/AJCR.908785DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6020799PMC
June 2018
4 Reads

Mycobacterium avium intracellulare infection complicated by allergic bronchopulmonary aspergillosis in a non-asthmatic patient.

BMJ Case Rep 2018 May 26;2018. Epub 2018 May 26.

Internal Medicine, Rosalind Franklin University of Medicine and Science, North Chicago, Illinois, USA.

Allergic bronchopulmonary aspergillosis (ABPA) most often develops in patients with asthma or cystic fibrosis. We present a 91-year-old non-asthmatic patient with pre-existing Mycobacteriumavium complex (MAC) infection who got diagnosed with ABPA. Treatment of the two conditions can be challenging as immunosuppression with steroids for treatment of ABPA may exacerbate the underlying MAC infection. Read More

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http://dx.doi.org/10.1136/bcr-2018-224835DOI Listing
May 2018
2 Reads

Disseminated Mycobacterium avium Infection Presenting with Bladder Lesions in a Patient with Interferon-γ-neutralizing Autoantibodies.

Intern Med 2018 Oct 18;57(20):3041-3045. Epub 2018 May 18.

Second Department of Internal Medicine, Hamamatsu University School of Medicine, Japan.

A 63-year-old woman presented with a fever, eruption, and sterile pyuria. A cystoscopic examination revealed submucosal nodular lesions in the trigone of the bladder, and a biopsy specimen showed epithelioid cell granulomas in the lamina propria of the bladder. Mycobacterium avium grew in the urine culture. Read More

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http://dx.doi.org/10.2169/internalmedicine.0965-18DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6232015PMC
October 2018
1 Read

Preliminary Study on Drug Susceptibility Profile and Resistance Mechanisms to Macrolides of Clinical Isolates of Non-tuberculous Mycobacteria from China.

Biomed Environ Sci 2018 Apr;31(4):290-299

State Key Laboratory for Infectious Diseases Prevention and Control, Collaborative Innovation Center for Diagnosis and Treatment of Infectious Diseases, National Institute for Communicable Disease Control and Prevention, Chinese Center for Disease Control and Prevention, Beijing 102206, China.

Objective: Macrolide susceptibility and drug resistance mechanisms of clinical non-tuberculous mycobacteria (NTM) isolates were preliminarily investigated for more accurate diagnosis and treatment of the infection in China.

Methods: Four macrolides, including clarithromycin (CLAR), azithromycin (AZM), roxithromycin (ROX), and erythromycin (ERY), were used to test the drug susceptibility of 310 clinical NTM isolates from six provinces of China with the broth microdilution method. Two resistance mechanisms, 23S rRNA and erm, were analyzed with nucleotide sequence analysis. Read More

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http://dx.doi.org/10.3967/bes2018.037DOI Listing
April 2018
10 Reads

Cutaneous Nontuberculous Mycobacterial Infections in Alberta, Canada: An Epidemiologic Study and Review.

J Cutan Med Surg 2018 Sep/Oct;22(5):479-483. Epub 2018 May 17.

3 Division of Diagnostic and Applied Microbiology, Department of Laboratory Medicine and Pathology, University of Alberta and the Alberta Provincial Public Health Laboratory, WC Mackenzie Health Sciences Centre, Edmonton, AB, Canada.

Background: Cutaneous infections caused by nontuberculous mycobacteria (NTM) occur infrequently. Nonetheless, the incidence of NTM infections is reported to be increasing. In Canada, cutaneous NTM infections have not been well described. Read More

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http://dx.doi.org/10.1177/1203475418776945DOI Listing
December 2018
16 Reads

Aspergillus precipitating antibody in patients with Mycobacterium avium complex lung disease: A cross-sectional study.

Respir Med 2018 05 12;138:1-6. Epub 2018 Mar 12.

Center for Infectious Diseases and Infection Control, Keio University School of Medicine, Tokyo, Japan. Electronic address:

Rationale: Little is known about the role of Aspergillus precipitating antibody (APAb) in patients with Mycobacterium avium complex lung disease (MAC-LD).

Objectives: We investigated the clinical characteristics of patients with MAC-LD positive for APAb.

Methods: We conducted a cross-sectional study targeting patients with MAC-LD. Read More

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http://dx.doi.org/10.1016/j.rmed.2018.03.013DOI Listing
May 2018
2 Reads

Pulmonary Mycobacterial Spindle Cell Pseudotumor: A Report of 3 Cases Including a Practical Approach to Histopathologic Recognition of This Unusual Entity.

Int J Surg Pathol 2018 Oct 2;26(7):629-634. Epub 2018 May 2.

1 Department of Pathology, University of Utah School of Medicine and Associated Regional and University Pathologists Laboratories, Salt Lake City, UT, USA.

Mycobacterial spindle cell pseudotumor (MSP) is a rare benign spindle cell lesion containing acid-fact mycobacteria. These lesions are most commonly identified in the lymph nodes, skin, spleen, or bone marrow of immunocompromised patients and only rarely involve the lungs. We report 3 cases of pulmonary MSP, which include 2 patients who are known to be HIV-positive. Read More

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http://dx.doi.org/10.1177/1066896918770010DOI Listing
October 2018
5 Reads

Risk stratification for the development of chronic pulmonary aspergillosis in patients with Mycobacterium avium complex lung disease.

J Infect Chemother 2018 Aug 26;24(8):654-659. Epub 2018 Apr 26.

Department of Respiratory Medicine, Ohara Healthcare Foundation, Kurashiki Central Hospital, Kurashiki, Japan.

Background: The number of patients with pulmonary nontuberculous mycobacterial disease complicated by chronic pulmonary aspergillosis (CPA) has been increasing. Additionally, CPA is reportedly associated with mortality in patients with Mycobacterium avium complex lung disease (MAC-LD). In the present study, we aimed to identify risk factors for developing CPA and stratify the risk for CPA development in patients with MAC-LD. Read More

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http://dx.doi.org/10.1016/j.jiac.2018.04.002DOI Listing
August 2018
6 Reads

Atypical mycobacteriosis in a poorly compliant patient.

BMJ Case Rep 2018 Apr 7;2018. Epub 2018 Apr 7.

Department of Internal Medicine, Hospital de Cascais Dr. José de Almeida, Alcabideche, Cascais, Portugal.

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http://casereports.bmj.com/lookup/doi/10.1136/bcr-2017-22190
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http://dx.doi.org/10.1136/bcr-2017-221902DOI Listing
April 2018
3 Reads

Hot Tub Lung: An Intriguing Diffuse Parenchymal Lung Disease.

Ghana Med J 2017 Sep;51(3):143-147

Lousiana State University Health Science Center. Shreveport. LA, USA.

In pulmonary medicine, identical pathogenesis due to varied etiological agents can present with indistinguishable clinical presentation, and produce similar laboratory and radiological changes. The importance of eliciting detailed occupational and social history from patients cannot be stressed enough when dealing with patients suffering from diffuse parenchymal lung diseases. Hot Tub Lung(HTL) is a perplexing pulmonary disease attributed to the Mycobacterium Avium-intracellulare Complex (MAC). Read More

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http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5870233PMC
September 2017
7 Reads

Diagnostic challenges in Mycobacteria chimaera infection.

QJM 2018 Jul;111(7):501-502

From the Department of Respiratory Medicine.

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http://dx.doi.org/10.1093/qjmed/hcy069DOI Listing
July 2018
1 Read

A case report of fatal disseminated Mycobacterium colombiense infection in a renal transplant recipient.

Transpl Infect Dis 2018 Aug 10;20(4):e12890. Epub 2018 Apr 10.

Division of Infectious Diseases, Department of Medicine, Faculty of Medicine, Ottawa Hospital General Campus, University of Ottawa, Ottawa, ON, Canada.

We report the first case of disseminated Mycobacterium colombiense infection in a solid organ transplant recipient. Co-infection with Cryptococcus neoformans led to fatal multisystem organ failure. We review the pathogen and host factors contributing to these opportunistic infections. Read More

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http://dx.doi.org/10.1111/tid.12890DOI Listing
August 2018
1 Read

Nontuberculous mycobacterial empyema in an immunocompetent child.

Authors:
Ira Shah Forum Shah

Indian J Pathol Microbiol 2018 Jan-Mar;61(1):141-142

Department of Pediatrics, Pediatric TB Clinic, B. J. Wadia Hospital for Children, Mumbai, Maharashtra, India.

Nontuberculous mycobacterium (NTM) species are mycobacterial species other than those belonging to the Mycobacterium Tuberculosis complex and Mycobacterium leprae. There are very few reports of NTM in immunocompetent children causing empyema. In this article, we report a 9-year-old immunocompetent girl who presented with Mycobacterium avium-intracellulare empyema. Read More

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http://dx.doi.org/10.4103/IJPM.IJPM_586_16DOI Listing
November 2018
2 Reads

Nontuberculous mycobacterial lung disease in a patient with COPD and bronchiectasis, with radiological signs of lung tumor.

Adv Respir Med 2018 ;86(1):17-22

Instytut Grużicy i Chorób Płuc, UL. Płocka 26, 01-138 Warszawa, Poland.

Mycobacterial lung disease is caused by nontuberculous mycobacteria (NTM), also known as atypical mycobacteria. NTM are widely distributed in the environment, particularly in soil and water; they may colonize the airways, gastrointestinal tract and genitourinary system, without the apparent signs of disease. Nevertheless, in some risk groups such as patients with chronic lung diseases or with immunodeficiency, mycobacterial lung disease is identified. Read More

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http://dx.doi.org/10.5603/ARM.2018.0005DOI Listing
September 2018
16 Reads

The many lives of nontuberculous mycobacteria.

J Bacteriol 2018 Feb 26. Epub 2018 Feb 26.

Department of Microbiology and Immunology, Medical College of Wisconsin, Milwaukee, Wisconsin, USA.

Nontuberculous mycobacteria (NTM) include species that colonize human epithelia, as well as species that are ubiquitous in soil and aquatic environments. NTM that primarily inhabit soil and aquatic environments include the complex (MAC, and ) and the complex (MABSC, subspecies , , and ), and can be free-living, biofilm-associated, or amoeba-associated. Although NTM are rarely pathogenic in immunocompetent individuals, those who are immunocompromised - due to either an inherited or acquired immunodeficiency - are highly susceptible to NTM infection (NTMI). Read More

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http://dx.doi.org/10.1128/JB.00739-17DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5952384PMC
February 2018
2 Reads

Successful treatment of non-tuberculous mycobacterial pleurisy with acute fever by antimycobacterial therapy.

BMJ Case Rep 2018 Feb 8;2018. Epub 2018 Feb 8.

Respiratory Medicine, Kurobe City Hospital, Kurobe, Japan.

We report two cases of pleurisy caused by non-tuberculous mycobacteria followed by pneumothorax. The onset of pleurisy was accompanied by acute fever. Cultured samples of the pleural effusions from the two patients, an 80-year-old man and an 87-year-old woman, were ultimately found to contain and , respectively. Read More

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http://casereports.bmj.com/lookup/doi/10.1136/bcr-2017-22243
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http://dx.doi.org/10.1136/bcr-2017-222439DOI Listing
February 2018
6 Reads

Penile complex spindle cell pseudotumor.

Indian J Dermatol Venereol Leprol 2018;84(2):199-202

Department of Internal Medicine, Ramon Y Cajal University Hospital, Madrid, Spain.

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http://dx.doi.org/10.4103/ijdvl.IJDVL_403_17DOI Listing
November 2018
3 Reads

Neutrophil predominance in bronchoalveolar lavage fluid is associated with disease severity and progression of HRCT findings in pulmonary Mycobacterium avium infection.

PLoS One 2018 5;13(2):e0190189. Epub 2018 Feb 5.

First Department of Medicine, Hokkaido University School of Medicine, Sapporo, Japan.

Pulmonary Mycobacterium avium complex (MAC) infection is increasing in prevalence worldwide even in immunocompetent individuals. Despite its variable clinical course, the clinical and immunological factors associated with radiographical severity and progression are not largely unknown. We aimed to study the association between the inflammatory cell and cytokine profiles at the local infected site, and the radiological severity and/or progression of pulmonary MAC infection. Read More

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http://journals.plos.org/plosone/article?id=10.1371/journal.pone.0190189PLOS
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5798761PMC
March 2018
9 Reads

The association between erythromycin monotherapy for Mycobacterium avium complex lung disease and cross-resistance to clarithromycin: A retrospective case-series study.

J Infect Chemother 2018 May 1;24(5):353-357. Epub 2018 Feb 1.

Department of Respiratory Medicine, National Hospital Organization, National Toneyama Hospital, Japan.

Long-term, low-dose erythromycin monotherapy, based on the anti-inflammatory effects of macrolides, has been reported to have the potential to suppress the exacerbation of Mycobacterium avium complex (MAC) lung disease with less toxicity. It remains unclear whether erythromycin monotherapy induces cross-resistance to clarithromycin, a key drug for MAC. To clarify this point, we conducted a retrospective, single-center, case-series study on patients with MAC lung disease who underwent erythromycin monotherapy for at least 6 months. Read More

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http://dx.doi.org/10.1016/j.jiac.2017.12.008DOI Listing
May 2018
13 Reads

Clinical significance and epidemiologic analyses of Mycobacterium avium and Mycobacterium intracellulare lung disease from post-marketing surveillance.

Respir Investig 2018 Jan 6;56(1):87-93. Epub 2017 Dec 6.

Department of Respiratory Medicine and Infectious Diseases, Oita University Faculty of Medicine, Oita, Japan. Electronic address:

Background: In Japan, nontuberculous mycobacterial lung disease is mostly attributable to Mycobacterium avium complex (MAC), i.e., M. Read More

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http://dx.doi.org/10.1016/j.resinv.2017.11.001DOI Listing
January 2018
5 Reads

Pulmonary Complex Infection in an Infant: A Silent and Coincidental Finding.

Pediatr Allergy Immunol Pulmonol 2017 12;30(4):257-259

University of Minnesota, Minneapolis, Minnesota.

An 11-month-old healthy infant girl was noted to have left lower lobe (LLL) opacities on chest X-ray (CXR) after developing desaturations during an elective cochlear implant surgery. Repeat CXR 10 days later revealed hyperexpansion of the left lung and persistent LLL opacity. Chest computerized tomography revealed enlarged mediastinal lymph nodes, left mainstem bronchial obstruction, and nodular opacities. Read More

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http://dx.doi.org/10.1089/ped.2017.0766DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5733643PMC
December 2017
4 Reads

Higher-than-expected prevalence of non-tuberculous mycobacteria in HIV setting in Botswana: Implications for diagnostic algorithms using Xpert MTB/RIF assay.

PLoS One 2017 22;12(12):e0189981. Epub 2017 Dec 22.

Centers for Disease Control and Prevention, Gaborone, Botswana.

Background: Non-tuberculous mycobacteria (NTM) can cause pulmonary infection and disease especially among people living with HIV (PLHIV). PLHIV with NTM disease may clinically present with one of the four symptoms consistent with tuberculosis (TB). We describe the prevalence of NTM and Mycobacterium tuberculosis complex (MTBC) isolated among PLHIV who presented for HIV care and treatment. Read More

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http://journals.plos.org/plosone/article?id=10.1371/journal.pone.0189981PLOS
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5741233PMC
January 2018
17 Reads

Disseminated infection with multiple abscesses on extremities in a woman with chronic corticosteroid therapy.

J Gen Fam Med 2017 12 15;18(6):425-427. Epub 2017 Jun 15.

Department of Infection Control and Prevention Kurume University School of Medicine Fukuoka Japan.

A 78-year-old Japanese woman with rheumatoid arthritis was admitted to our hospital due to fever. She had been prescribed prednisolone and bucillamine. Computed tomography revealed abscesses on extremities. Read More

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http://dx.doi.org/10.1002/jgf2.99DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5729362PMC
December 2017
4 Reads

A fast-growing cold skin abscess revealing disseminated Mycobacterium intracellulare infection in an HIV-infected patient.

Int J STD AIDS 2018 06 19;29(7):720-722. Epub 2017 Dec 19.

1 Department of Dermatology and Venereology, Centro Hospitalar de Lisboa Central, Lisboa, Portugal.

A 66-year-old woman with HIV-1 infection recently commenced on antiretroviral therapy (CD4+ 25 cells/mm was referred to the Dermatology Clinic the following month due to a well-demarcated nodule in the extensor surface of the left arm with evident fluctuation but only slight pain on palpation, with no increase in temperature. Surgical drainage was performed with aspiration of yellowish-green exudate, with no characteristic smell. In culture of cutaneous exudate, Mycobacterium intracellulare was isolated. Read More

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http://dx.doi.org/10.1177/0956462417748240DOI Listing
June 2018
4 Reads

Impact of chronic Pseudomonas aeruginosa infection on health-related quality of life in Mycobacterium avium complex lung disease.

BMC Pulm Med 2017 Dec 13;17(1):198. Epub 2017 Dec 13.

Center for Infectious Diseases and Infection Control, Keio University School of Medicine, 35 Shinanomachi, Shinjuku, Tokyo, 160-8582, Japan.

Background: In bronchiectasis patients, chronic Pseudomonas aeruginosa (PA) infection has been associated with worse health-related quality of life (HRQL), but little is known about Mycobacterium avium complex lung disease (MACLD) patients in this context. This study aimed to evaluate HRQL and investigate the impact of chronic PA infection in MACLD patients.

Methods: This cross-sectional study was conducted using the Registry of Prospective Cohort Study including MACLD patients. Read More

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http://dx.doi.org/10.1186/s12890-017-0544-xDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5727955PMC
December 2017
14 Reads

Bilateral choroiditis as the only sign of persistent Mycobacterium intracellulare infection following haematogenous spread in an immunocompromised patient.

Infection 2018 Jun 9;46(3):423-426. Epub 2017 Dec 9.

Department of Clinical Sciences, Luigi Sacco Hospital, Section of Infectious and Tropical Diseases, University of Milan, Milan, Italy.

An immunocompromised patient had positive blood cultures for Mycobacterium intracellulare and no identifiable organ seeding was started on treatment. One month later, the patient was clinically well with negative blood cultures but drug-induced myelotoxicity had developed. Ocular fundus examination at this time revealed bilateral choroidal granulomas which changed patient management. Read More

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http://dx.doi.org/10.1007/s15010-017-1109-xDOI Listing
June 2018
14 Reads

Differences in drug susceptibility pattern between Mycobacterium avium and Mycobacterium intracellulare isolated in respiratory specimens.

J Infect Chemother 2018 Apr 7;24(4):315-318. Epub 2017 Dec 7.

Department of Laboratory Medicine and Genetics, Samsung Medical Center, Sungkyunkwan University School of Medicine, Seoul, South Korea. Electronic address:

Mycobacterium avium complex (MAC) is the most common etiologic organisms of nontuberculous mycobacteria (NTM) lung disease. In this study, we aimed to retrospectively investigate the differences in drug susceptibility patterns of two major MAC species; Mycobacterium avium and Mycobacterium intracellulare. A total of 1883 major two MAC isolates (1060 M. Read More

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http://dx.doi.org/10.1016/j.jiac.2017.10.022DOI Listing
April 2018
14 Reads
1.380 Impact Factor

Successful Diagnosis of Intestinal Mycobacterium avium Complex Infection in a Kidney Transplant Recipient Using Nasogastric Aspirate Culture: A Case Report.

Transplant Proc 2017 Dec;49(10):2362-2364

Division of Infectious Disease, Department of Internal Medicine, University of Texas Southwestern Medical Center, Dallas, Texas.

Intestinal Mycobacterium avium complex (MAC) infections are rare and can be challenging to diagnose. We describe a case of intestinal MAC infection in a kidney transplant recipient with 5 months of unexplained weight loss and abdominal pain who developed intestinal obstruction. Esophagoduodenoscopy with biopsies was performed but was nondiagnostic. Read More

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https://linkinghub.elsevier.com/retrieve/pii/S00411345173066
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http://dx.doi.org/10.1016/j.transproceed.2017.09.009DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5726570PMC
December 2017
5 Reads

[Infection by the Mycobacterium avium-intracellulare complex in patients with HIV/AIDS in a Peruvian hospital: A series of cases].

Rev Peru Med Exp Salud Publica 2017 Apr-Jun;34(2):323-327

Servicio de Medicina en Enfermedades Infecciosas y Tropicales, Hospital Nacional Dos de Mayo. Lima, Perú.

There is little information on the presence of the Mycobacterium avium-Intracellulare (MAC) complex in Peru. Five cases of MAC infection are described in patients with HIV/AIDS at the National Hospital Dos de Mayo, Lima - Peru. The patients presented, mainly, persistent fever, chronic diarrhea, consumptive syndrome, pancytopenia and citofagocitosis. Read More

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http://dx.doi.org/10.17843/rpmesp.2017.342.2476DOI Listing
August 2018
3 Reads

Epidemiology and Predictors of NTM Pulmonary Infection in Taiwan - a Retrospective, Five-Year Multicenter Study.

Sci Rep 2017 Nov 24;7(1):16300. Epub 2017 Nov 24.

Department of Laboratory Medicine, Fu Jen Catholic University Hospital, New Taipei City, Taiwan.

Multicenter, longitudinal studies on nontuberculous mycobacteria (NTM) pulmonary infection (PI) are lacking. This study provides a 5-year epidemiological overview of NTM-PI in Taiwan and investigated its predictors. The clinical relevance of each respiratory NTM isolate in six hospitals between 2008 and 2014 was determined according to current guidelines. Read More

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http://dx.doi.org/10.1038/s41598-017-16559-zDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5701172PMC
November 2017
8 Reads