7,417 results match your criteria Mycobacterium Avium-Intracellulare


Identification Using MALDI-TOF MS Technology: A Practical Approach for the Clinical Microbiology Laboratories.

Microorganisms 2022 Jun 9;10(6). Epub 2022 Jun 9.

Clinical Microbiology Laboratory, Arcispedale S. Maria Nuova, IRCCS Azienda Unità Sanitaria Locale, 42122 Reggio Emilia, Italy.

(MC) is an environmental, slowly growing, non-tuberculous mycobacterium (NTM) belonging to complex (MAC), which recently has been linked to severe cardiovascular infections following open heart and vascular surgery. The majority of the diagnostic laboratory tests used in routine are not able to distinguish MC from (MI), because of the great genetic similarity existing between these two species. The Genotype Mycobacterium NTM-DR™ represents a valid method to differentiate between these species, but it is expensive, requiring also specialized personnel. Read More

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Pleurisy with pneumothorax due to CAM-resistant MAC lung disease.

Respirol Case Rep 2022 Jul 14;10(7):e0993. Epub 2022 Jun 14.

Department of Respiratory Medicine Shuuwa General Hospital Saitama Japan.

A 72-year-old man received rifampicin, ethambutol and sitafloxacin to treat clarithromycin (CAM)-resistant complex (MAC) lung disease. He was admitted because of fever. Pneumothorax and pleural effusion were present in the right lung, and a new consolidation appeared in the right upper lobe. Read More

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Tolerability, adverse events, and efficacy of treatment for Mycobacterium avium complex pulmonary disease in elderly patients.

J Infect Chemother 2022 Jun 17. Epub 2022 Jun 17.

Department of Respiratory Medicine, Allergy and Clinical Immunology, Nagoya City University Graduate School of Medical Sciences, Nagoya, Japan.

Introduction: Although the number of patients with Mycobacterium avium complex (MAC) pulmonary disease has been increasing among the elderly individuals due to population aging in Japan, few studies have reported treatment in elderly patients with MAC pulmonary disease. We conducted a retrospective cohort study to evaluate differences in the tolerability of, adverse events associated with and efficacy of treatment for MAC pulmonary disease in elderly and nonelderly patients.

Methods: The medical records of 96 newly diagnosed MAC pulmonary disease patients at Nagoya City University Hospital between April 2014 and March 2019 were reviewed. Read More

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Immunological and Hemato-biochemical alterations in diarrhoeic buffaloes screened for Mycobacterium avium subspecies paratuberculosis infection using 'indigenous ELISA kit'.

Comp Immunol Microbiol Infect Dis 2022 Jun 8;87:101833. Epub 2022 Jun 8.

Department of Bio-technology, GLA University, Post-Chaumuhan, Dist. Mathura, Uttar Pradesh 281 406, India.

Paratuberculosis (ParaTB) in ruminants, commonly known as Johne's disease (JD)is caused by Mycobacterium avium subspecies paratuberculosis (MAP). Characteristic hallmark of JD is chronic inflammation of intestines. Similar infection of MAP in human population is called Crohn's disease (CD). Read More

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Imaging findings of vertebral osteomyelitis caused by nontuberculous mycobacterial organisms: Three case reports and literature review.

Medicine (Baltimore) 2022 Jun 17;101(24):e29395. Epub 2022 Jun 17.

Department of Radiology, Sir Run Run Shaw Hospital, School of Medicine, Zhejiang University, Hangzhou, Zhejiang, China.

Rationale: Prompt diagnosis of nontuberculous Mycobacterial (NTM) vertebral osteomyelitis is challenging, yet necessary to prevent serious morbidity and mortality. Here, we report 3 cases of vertebral osteomyelitis caused by NTM with imaging findings.

Patient Concerns: Case 1, a 58-year-old male patient, was admitted to our hospital because of the presence of a pulmonary mass for 6 months with cough and chest pain. Read More

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activity of fidaxomicin against nontuberculosis mycobacteria.

J Med Microbiol 2022 Jun;71(6)

College of Veterinary Medicine, China Agricultural University, Beijing, PR China.

Nontuberculous mycobacteria (NTM) infections are increasing worldwide and are relatively resistant to many of the first- and second-line drugs to treat tuberculosis. Macrolide antibiotics, such as clarithromycin and azithromycin, are the key drugs for treating NTM infections. Fidaxomicin is a macrolide antibiotic that is widely used in treating infections, and has high activity against especially multidrug-resistant tuberculosis (MDR-TB) and has no cross-resistance with rifampicin. Read More

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Progression and Dissemination of Pulmonary Mycobacterium Avium Infection in a Susceptible Immunocompetent Mouse Model.

Int J Mol Sci 2022 May 26;23(11). Epub 2022 May 26.

National Emerging Infectious Diseases Laboratories, Boston University, Boston, MA 02215, USA.

Pulmonary infections caused by the group of nontuberculosis mycobacteria (NTM), Mycobacterium avium complex (MAC), are a growing public health concern with incidence and mortality steadily increasing globally. Granulomatous inflammation is the hallmark of MAC lung infection, yet reliable correlates of disease progression, susceptibility, and resolution are poorly defined. Unlike widely used inbred mouse strains, mice that carry the mutant allele at the genetic locus sst1 develop human-like pulmonary tuberculosis featuring well-organized caseating granulomas. Read More

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Sphingosine-1-phosphate receptors 2 and 3 reprogram resting human macrophages into M1 phenotype following mycobacteria infection.

Curr Res Immunol 2022 3;3:110-117. Epub 2022 Jun 3.

Centre of Interdisciplinary Research in Basic Science (CIRBSc), Jamia Millia Islamia, New Delhi, India.

() the causative agent for tuberculosis has been accredited for a high rate of morbidity and mortality worldwide. The rise in MDR and XDR cases has further created new obstacles in achieving the "End TB Strategy", which is aimed for 2035. In this article, we have demonstrated the potential of sphingosine-1-phosphate (S1P) analogs in providing an anti-mycobacterial effector response by altering macrophage polarity into M1. Read More

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Colitis and Intestinal Granulomas in Acquired Immunodeficiency Syndrome.

Clin J Gastroenterol 2022 Jun 8. Epub 2022 Jun 8.

Division of Gastroenterology-Hepatology, Department of Medicine, University of Connecticut Health Center, Farmington, CT, 06030, USA.

Granulomas consist of focal collections of immune cells that forms as a result of chronic inflammation. They can be formed in different organs and are considered the hallmark for several inflammatory and infectious diseases. The presence of granulomas in the mucosal biopsies of the gastrointestinal (GI) tract of immunocompetent patients, along with histological features of chronicity, confirms the diagnosis of Crohn's disease (CD) in the majority of cases. Read More

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Identification and drug susceptibility testing of the subspecies of Mycobacterium avium complex clinical isolates in mainland China.

J Glob Antimicrob Resist 2022 Jun 2. Epub 2022 Jun 2.

Department of Pulmonary and Critical Care Medicine, Beijing Hospital, National Center of Gerontology, National Health Commission; Institute of Geriatric Medicine, Chinese Academy of Medical Sciences, Beijing, P.R. China. Electronic address:

Background: The Mycobacterium avium complex (MAC), comprising a series of subspecies, has a worldwide distribution, with differences in drug susceptibility among subspecies. This study aimed to assess the composition of MAC and susceptibility differences among subspecies in mainland China.

Methods: A total of 287 MAC clinical strains were included in the study. Read More

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MIRU-VNTR Typing of Atypical Mycobacteria Isolated from the Lymph Nodes of Slaughtered Pigs from Poland.

Pathogens 2022 Apr 21;11(5). Epub 2022 Apr 21.

Institute of Medical Biology, Polish Academy of Sciences, Lodowa 106, 93-232 Lodz, Poland.

No regulations currently require the excision of lymph nodes from pig carcasses or the thermal processing of pork before consumption. Therefore, the presence of anatomopathological lesions with signs of coagulation necrosis in lymph nodes from pigs during post-mortem inspection is concerning, as is the increasing incidence of mycobacteriosis in humans. Therefore, the aim of the present study is to verify whether mycobacteria can be isolated from tuberculous-like lesions in mandibular lymph nodes in slaughtered pigs, and whether further molecular analysis based on MIRU-VNRT, used to identify mycobacteria from the complex, can indicate zoonotic potential. Read More

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Risk Factors for the Development of Nontuberculous Mycobacteria Pulmonary Disease during Long-Term Follow-Up after Lung Cancer Surgery.

Diagnostics (Basel) 2022 Apr 27;12(5). Epub 2022 Apr 27.

Division of Pulmonary and Critical Care Medicine, Department of Medicine, Samsung Medical Center, School of Medicine, Sungkyunkwan University, Irwon-ro 81, Gangnam-gu, Seoul 06351, Korea.

The aim of this study is to determine the cumulative incidence of, and the risk factors for, the development of nontuberculous mycobacteria pulmonary disease (NTM-PD) following lung cancer surgery. We retrospectively analyzed patients with non-small cell lung cancer who underwent surgical resection between 2010 and 2016. Patients who met all the diagnostic criteria in the NTM guidelines were defined as having NTM-PD. Read More

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Activity of Antibiotics and Potential Antibiofilm Agents against Biofilm-Producing - Complex Causing Chronic Pulmonary Infections.

Antibiotics (Basel) 2022 Apr 27;11(5). Epub 2022 Apr 27.

Departament de Fonaments Clínics, Facultat de Medicina i Ciències de la Salut, Universitat de Barcelona, c/Casanova 143, 08036 Barcelona, Spain.

Nontuberculous mycobacteria (NTM) cause lung infections in patients with underlying pulmonary diseases (PD). The - complex (MAC) is the most frequently involved NTM. The MAC-PD treatment is based on the administration of several antibiotics for long periods of time. Read More

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Evaluation of Mycobacterium avium complex pulmonary disease treatment completion and adherence to ATS/IDSA guidelines.

Clin Infect Dis 2022 May 24. Epub 2022 May 24.

Oregon Health & Science University, Portland, Oregon, USA.

Introduction: Nontuberculous mycobacteria are environmental organisms that cause infections leading to chronic, debilitating pulmonary disease, among which Mycobacterium avium complex (MAC) is the most common species.

Methods: We described patterns of macrolide-based multi-drug antibiotic therapies for MAC pulmonary disease (MAC-PD) in U.S. Read More

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Identification of nontuberculous mycobacteria isolated from household showerheads of patients with nontuberculous mycobacteria.

Sci Rep 2022 May 23;12(1):8648. Epub 2022 May 23.

Division of Pulmonary and Critical Care Medicine, Department of Internal Medicine, Severance Hospital, Yonsei University College of Medicine, 50-1 Yonsei-ro, Seodaemun-gu, Seoul, 03722, Republic of Korea.

This study aimed to examine whether nontuberculous mycobacteria (NTM) inside household showerheads are identical to those in patients with NTM-pulmonary disease (PD) since household water is one of the potential NTM sources. Samples were obtained from 32 household showerheads of patients with NTM-PD recruited through the Pulmonary Outpatient Department at the Severance Hospital between October 2018 and October 2019. All isolates from patients with NTM-PD were diagnosed using a reverse-hybridization line probe assay based on the ropB gene. Read More

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sp. nov., a slowly growing, non-scotochromogenic species, isolated from sputum of an elderly man.

Int J Syst Evol Microbiol 2022 May;72(5)

Department of Respiratory Medicine, National Hospital Organization Osaka Toneyama Medical Center, 5-1-1 Toneyama Toyonaka, Osaka, Japan.

A slowly growing mycobacteria, identified as strain TY59, was isolated from sputum of an elderly man with pneumonia. Sequencing of the 16S rRNA gene indicated that this strain was similar to members of the complex and closely related species. Strain TY59 has highest 16S rRNA gene sequence similarities to the type strains of (99. Read More

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Disseminated Nontuberculous Mycobacterium Presenting as Chronic Diarrhea and Wasting.

J Investig Med High Impact Case Rep 2022 Jan-Dec;10:23247096221101860

Medical University of South Carolina, Charleston, USA.

Infections due to nontuberculous mycobacterium (NTM) are important in chronically immunosuppressed populations and are a particular threat to solid organ transplant recipients (SOT). However, they are not a common occurrence and have protean manifestations, making it important that clinicians maintain a high degree of suspicion in the correct patient population. complex (MAC) usually presents with pulmonary involvement in immunocompetent population and disseminated disease in SOT patients with fever of unknown origin, lymphadenopathy, and cutaneous lesions being part of the well-known presentation. Read More

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Osteoporosis in nontuberculous mycobacterial pulmonary disease: a cross-sectional study.

BMC Pulm Med 2022 May 21;22(1):202. Epub 2022 May 21.

Department of Infectious Diseases, Keio University School of Medicine, 35 Shinanomachi, Shinjuku, Tokyo, 160-8582, Japan.

Background: Since nontuberculous mycobacterial pulmonary disease (NTM-PD) is common in middle-aged/elderly slender women at risk of osteoporosis, we hypothesized that NTM-PD could be associated with osteoporosis. The study aimed to evaluate the prevalence of osteoporosis in patients with NTM-PD compared with that in the general population and determine the factors associated with osteoporosis in the subjects, including the serum estradiol (E) and 25-hydroxyvitamin D (25OHD) levels.

Methods: We have recruited 228 consecutive adult patients with NTM-PD from a prospective cohort study at the Keio University Hospital, who had no history of osteoporosis or osteoporosis-associated bone fracture but underwent dual-energy X-ray absorptiometry-based bone mineral density (BMD) evaluation from August 2017-September 2019. Read More

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Impact of lung cancer surgery on comorbid complex lung disease-A case series.

Respir Med Case Rep 2022 4;37:101664. Epub 2022 May 4.

Department of Information Science, Iwate Medical University, Yahaba, Iwate, 028-3694, Japan.

The number of cases with and lung diseases complex lung disease [MACLD are increasing globally. Lung cancer can sometimes present as a comorbidity with MACLD; however, the clinical presentation and outcomes of comorbid MACLD following lung cancer resection remain unclear. Therefore, we retrospectively assessed 17 patients with MACLD undergoing lung cancer resection to determine the impact of lung cancer surgery on comorbid MACLD. Read More

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Novel Screening System of Virulent Strains for the Establishment of a Complex Lung Disease Mouse Model Using Whole-Genome Sequencing.

Microbiol Spectr 2022 May 17:e0045122. Epub 2022 May 17.

Department of Basic Mycobacteriosis, Nagasaki University Graduate School of Biomedical Sciences, Nagasaki, Japan.

The establishment of animal models reflecting human Mycobacterium avium complex (MAC) lung disease (LD) pathology has the potential to expand our understanding of the disease pathophysiology. However, inducing sustained infection in immunocompetent mice is difficult since MAC generally shows less virulence and higher genetic variability than M. tuberculosis. Read More

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Complex Infection as a Rare Cause of Cerebral Mass Lesion and IRIS in a Patient With AIDS: Case Report and Review of the Literature.

Open Forum Infect Dis 2021 Nov 30;8(11):ofab450. Epub 2021 Oct 30.

Division of HIV, Infectious Diseases and Global Medicine, Department of Medicine, Zuckerberg San Francisco General Hospital and Trauma Center, University of California San Francisco, San Francisco, California, USA.

A patient with advanced HIV/AIDS presented with a brain abscess. While brain biopsy culture and pathology were unrevealing, universal broad-range polymerase chain reaction (uPCR) demonstrated complex (MAC). We review the clinicopathologic characteristics of MAC brain abscesses and highlight the effectiveness of uPCR as a diagnostic tool in partially treated infections. Read More

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November 2021

Adaptive Immune Response to Complex (MABSC) in Cystic Fibrosis and the Implications of Cross-Reactivity.

Front Cell Infect Microbiol 2022 20;12:858398. Epub 2022 Apr 20.

Clinical Microbiology Department, Rigshospitalet (Copenhagen University Hospital), Copenhagen, Denmark.

Background: We aimed to characterise the adaptive immune response to complex (MABSC) and its cross-reactivity with complex (MAC) and (Bacille Calmette-Guérin, BCG) in cystic fibrosis (CF) patients and non-CF controls in terms of lymphocyte proliferation and immunophenotyping, cytokine production and anti-MABSC IgG plasma levels.

Methods: In this cross-sectional analysis, peripheral blood mononuclear cells (PBMC) from CF patients with MABSC (CF/MABSC, n=12), MAC infection history (CF/MAC, n=5), no NTM history (CF/NTM-, n=15), BCG-vaccinated (C/BCG+, n=9) and non-vaccinated controls (C/BCG-, n=8) were cultured for four days under stimulation with an in-house MABSC lysate and we used flow cytometry to assess lymphocyte proliferation (given by lymphoblast formation) and immunophenotypes. Cytokine production was assessed after overnight whole blood stimulation with the same lysate, and anti-MABSC IgG levels were measured in plasma from non-stimulated blood. Read More

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Searching for new therapeutic options for the uncommon pathogen Mycobacterium chimaera: an open drug discovery approach.

Lancet Microbe 2022 May 1;3(5):e382-e391. Epub 2022 Apr 1.

Department of Global Health and Infection, Brighton and Sussex Medical School, University of Sussex, Falmer, UK. Electronic address:

Background: Mycobacterium chimaera is a slowly growing non-tuberculous mycobacterium associated with outbreaks of fatal infections in patients after cardiac surgery, and it is increasingly being detected in patients with chronic lung conditions. M chimaera can cause disseminated disease, osteomyelitis, and chronic skin or soft-tissue infections. We aimed to find new inhibitory compounds and drug repurposing opportunities for M chimaera, as current therapeutic options often result in poor outcomes. Read More

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Nontuberculous Mycobacterial Infections.

Radiol Clin North Am 2022 May;60(3):399-408

Department of Radiology, Brigham and Women's Hospital, 75 Francis Street, Boston, MA 02115, USA. Electronic address:

Mycobacterial species other than Mycobacterium tuberculosis and Mycobacterium leprae constitute nontuberculous mycobacteria (NTM). NTM infections are on the rise, particularly in the Western world. They cause a wide range of pulmonary and systemic manifestations. Read More

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complex pulmonary disease: does the diagnostic method affect severity and progression?

Int J Tuberc Lung Dis 2022 05;26(5):412-418

Department of Respiratory Medicine, Showa University Northern Yokohama Hospital, Yokohama, Japan.

Diagnosis of complex pulmonary disease (MAC-PD) requires positive culture of expectorated sputum or specimens acquired by bronchoscopy. Whether patients diagnosed using bronchoscopy have milder disease and milder progression than those diagnosed using sputum remains uncertain. To clarify whether disease severity and progression differ according to the diagnostic method. Read More

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Vaccination inducing durable and robust antigen-specific Th1/Th17 immune responses contributes to prophylactic protection against infection but is ineffective as an adjunct to antibiotic treatment in chronic disease.

Virulence 2022 12;13(1):808-832

Department of Microbiology, Institute for Immunology and Immunological Disease, Graduate School of Medical science, Brain Korea 21 Project, Yonsei University College of Medicine, Seoul, South Korea.

complex (MAC) causing pulmonary disease in humanshas emerged worldwide. Thus, effective strategies simultaneously aiming to prevent MAC infection and accelerate therapeutic efficacy are required. To this end, subunit vaccine-induced protection against a well-defined virulent (Mav) isolate was assessed as a preventative and therapeutic modality in murine models. Read More

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December 2022

Disseminated and infection in a patient with AIDS: A case report and review of literature.

J Clin Tuberc Other Mycobact Dis 2022 May 12;27:100314. Epub 2022 Apr 12.

Division of Infectious Diseases, Department of Internal Medicine, Chang Gung Memorial Hospital Linkou Branch, Chang Gung University College of Medicine, 5 Fuxing St., Guishan Dist., Taoyuan 33305, Taiwan.

Disseminated nontuberculous mycobacterial infections are frequently recognized in patients living with human immunodeficiency virus/acquired immunodeficiency syndrome (AIDS) and complex (MAIC) is the most common species. is a rapidly growing mycobacterium that accounts for 1-2% of community-acquired and healthcare-associated infections. It mainly causes skin and soft tissue infection. Read More

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Mycobacterium avium complex infected cells promote growth of the pathogen Pseudomonas aeruginosa.

Microb Pathog 2022 May 22;166:105549. Epub 2022 Apr 22.

Unidad de Investigación, Complejo Asistencial Universitario de León, Gerencia Regional de Salud de Castilla y León (SACYL), Altos de Nava, s/n, 24071, León, Spain; Institute of Biomedical Research of Salamanca (IBSAL), Spain; Institute of Biomedicine, University of León, León, Spain. Electronic address:

Bronchiectasis is considered a consequence of the neutrophilic inflammatory response to infection. Mycobacterial infections, mainly from the Mycobacterium avium complex and M. abscessus, have been inextricably linked to bronchiectasis development. Read More

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