6,687 results match your criteria Mycobacterium Avium-Intracellulare


Infection in a C3HeB/FeJ Mouse Model.

Front Microbiol 2019 3;10:693. Epub 2019 Apr 3.

Mycobacteria Research Laboratories, Department of Microbiology, Immunology and Pathology, Colorado State University, Fort Collins, CO, United States.

Infections caused by complex (MAC) species are increasing worldwide, resulting in a serious public health problem. Patients with MAC lung disease face an arduous journey of a prolonged multidrug regimen that is often poorly tolerated and associated with relatively poor outcome. Identification of new animal models that demonstrate a similar pulmonary pathology as humans infected with MAC has the potential to significantly advance our understanding of nontuberculosis mycobacteria (NTM) pathogenesis as well as provide a tractable model for screening candidate compounds for therapy. Read More

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http://dx.doi.org/10.3389/fmicb.2019.00693DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6456659PMC

Discovery of Nosiheptide, Griseoviridin, and Etamycin as Potent Anti-Mycobacterial Agents against Mycobacterium avium Complex.

Molecules 2019 Apr 16;24(8). Epub 2019 Apr 16.

Department of Microbial Chemistry, Graduate School of Pharmaceutical Sciences, Kitasato University, Tokyo 108-8641, Japan.

complex (MAC) is a serious disease mainly caused by and Although the incidence of MAC infection is increasing worldwide, only a few agents are clinically used, and their therapeutic effects are limited. Therefore, new anti-MAC agents are needed. Approximately 6600 microbial samples were screened for new anti-mycobacterial agents that inhibit the growth of both M. Read More

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https://www.mdpi.com/1420-3049/24/8/1495
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http://dx.doi.org/10.3390/molecules24081495DOI Listing
April 2019
1 Read

Mycobacterium chimaera infection masquerading as a lung mass in a healthcare worker.

IDCases 2019 26;15:e00526. Epub 2019 Mar 26.

Department of Internal Medicine, Division of Infectious Diseases, James H. Quillen College of Medicine, East Tennessee State University, Johnson City, TN 37614, United States.

, a nontuberculous mycobacterium, is a member of the complex (MAC). This microorganism has recently gained significant notoriety for its association with outbreaks in patients exposed to contaminated heater -cooler devices used during open heart surgeries. We report a case of pulmonary infection in a healthcare worker who presented with cough, low grade fever and weight loss with evidence of a lung mass that was initially thought to be a tumor on CT scan imaging. Read More

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https://linkinghub.elsevier.com/retrieve/pii/S22142509193004
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http://dx.doi.org/10.1016/j.idcr.2019.e00526DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6446050PMC
March 2019
1 Read

Mycobacterium Avium Complex Diversity within Lung Disease as Revealed by Whole Genome Sequencing.

Am J Respir Crit Care Med 2019 Apr 9. Epub 2019 Apr 9.

University of Virginia, 2358, Division of Infectious Dieseases and International Health, Charlottesville, Virginia, United States ;

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http://dx.doi.org/10.1164/rccm.201903-0669LEDOI Listing

The natural history of non-cavitary nodular bronchiectatic Mycobacterium avium complex lung disease.

Respir Med 2019 Apr 12;150:45-50. Epub 2019 Feb 12.

Division of Pulmonology and Critical Care Medicine, University of Ulsan College of Medicine, Asan Medical Centre, 88 Olympic-ro 43-gil, Songpa-gu, 05505, Seoul, South Korea. Electronic address:

Purpose: We aimed to investigate the natural history of non-cavitary nodular bronchiectatic (NC-NB) Mycobacterium avium complex (MAC) lung disease (LD).

Methods: Among all patients diagnosed with NC-NB MAC LD between March 2000 and December 2013, 551 patients who were followed until December 2017 were enrolled at a tertiary referral center in South Korea. Patients were subdivided into progressive and stationary groups, depending on whether treatment was initiated within 3 years after diagnosis. Read More

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http://dx.doi.org/10.1016/j.rmed.2019.02.007DOI Listing

Unusual cause of progressively impaired cognitive function: complex meningoencephalitis.

BMJ Case Rep 2019 Apr 3;12(4). Epub 2019 Apr 3.

Department of Internal Medicine, Akiota Hospital, Yamagata-gun, Hiroshima, Japan.

complex (MAC) is a rare cause of meningoencephalitis. Non-tuberculous mycobacterium meningoencephalitis including MAC meningoencephalitis is an important cause of rapidly progressive dementia. We present a case of MAC meningoencephalitis in an immunosuppressed woman who had progressively impaired cognitive function. Read More

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http://casereports.bmj.com/lookup/doi/10.1136/bcr-2018-22902
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http://dx.doi.org/10.1136/bcr-2018-229022DOI Listing
April 2019
5 Reads

JVA, an isoniazid analogue, is a bioactive compound against a clinical isolate of the Mycobacterium avium complex.

Tuberculosis (Edinb) 2019 03 5;115:108-112. Epub 2019 Mar 5.

Departamento de Bioquímica e Imunologia, Instituto de Ciências Biológicas, Universidade Federal de Minas Gerais, Belo Horizonte, Brazil; Instituto Nacional de Ciência e Tecnologia em Doenças Tropicais (INCT-DT), CNPq MCT, Salvador, BA, Brazil. Electronic address:

Bacteria belonging to Mycobacterium avium complex are organisms of low pathogenicity that infect immunosuppressed individuals. Infection is treated with an antimicrobial macrolide, Clarithromycin (CAM) or Azitromycin, associated with Ethambutol and Rifabutin during 12 months. Regimen long duration and side effects hinder patient's commitment to treatment favoring emergence of antibiotic resistance. Read More

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http://dx.doi.org/10.1016/j.tube.2019.03.002DOI Listing
March 2019
1 Read

Correction to: Amikacin Liposome Inhalation Suspension: A Review in Mycobacterium avium Complex Lung Disease.

Authors:
Matt Shirley

Drugs 2019 Apr 3. Epub 2019 Apr 3.

Springer, Private Bag 65901, Mairangi Bay, Auckland, 0754, New Zealand.

The article Amikacin Liposome Inhalation Suspension: A Review in Mycobacterium avium Complex Lung Disease. Read More

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http://dx.doi.org/10.1007/s40265-019-01111-2DOI Listing
April 2019
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Mycobacterium Avium Complex Presenting as Pulmonary Nodules in a Child With Sickle Cell Disease.

J Pediatr Hematol Oncol 2019 Mar 29. Epub 2019 Mar 29.

Departments of Pediatrics, Texas A&M Health Science Center, Scott & White Medical Center-Temple, Temple, TX.

The case of a 10-year-old child with sickle cell disease with pulmonary nodules and prolonged fevers is reported here. The child was first diagnosed with sarcoidosis based on lung biopsy, but unresponsiveness to therapy led to a second lung biopsy, which revealed the true diagnosis of mycobacterium avium complex disease. Multiple possible explanations for why the patient became infected exist. Read More

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http://dx.doi.org/10.1097/MPH.0000000000001458DOI Listing
March 2019
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Clinical characteristics, drug resistance, and pathogenic spectrum of patients co-infected with nontuberculous mycobacteria and human-immunodeficiency virus in Chengdu, Sichuan, China.

Chin Med J (Engl) 2019 Mar 27. Epub 2019 Mar 27.

Department of Clinical Laboratory, Public Health Clinical Center of Chengdu, Chengdu, Sichuan 610066, China.

Background: Human-immunodeficiency virus (HIV) infection is increasing worldwide and nontuberculous mycobacteria (NTM) is an established microbiologic cause of pulmonary disease, lymphadenitis, and disseminated disease in cases of advanced immune suppression. Data on patients co-infected with HIV and NTM are limited, this study aimed to analyze the clinical characteristics, drug resistance, and pathogen spectrum of patients co-infected with HIV and NTM in the Chengdu area of China to provide a scientific basis for the prevention, control, diagnosis, and treatment of the disease.

Methods: Data of 59 patients co-infected with HIV and NTM collected from the Public Health Clinical Center of Chengdu, between January 2014 and December 2018, were analyzed. Read More

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http://dx.doi.org/10.1097/CM9.0000000000000235DOI Listing
March 2019
5 Reads
1.016 Impact Factor

Synergistic potential of Juniperus communis and Helichrysum italicum essential oils against nontuberculous mycobacteria.

J Med Microbiol 2019 Mar 27. Epub 2019 Mar 27.

1 Department of Microbiology and Parasitology, Faculty of Medicine, University of Rijeka, Rijeka, Croatia.

Objective: The present study evaluated the possible synergistic antimycobacterial interactions of Juniperus communis and Helichrysum italicum essential oils (EO).

Methods: Antimycobacterial potential was tested against Mycobacterium avium and Mycobacterium intracellulare using broth and water dilution method and checkerboard synergy method. Antiadhesion and antibiofilm effect of EOs was evaluated on biotic (HeLa cells) and abiotic surface (polystyrene). Read More

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http://dx.doi.org/10.1099/jmm.0.000962DOI Listing
March 2019
2 Reads

: Environmental Bacterium Turned Clinical Nightmare.

Microorganisms 2019 Mar 22;7(3). Epub 2019 Mar 22.

School of Life and Health Sciences, Aston University, Aston Triangle, Birmingham B4 7ET, UK.

Mycobacteria are a large family of over 100 species, most of which do not cause diseases in humans. The majority of the mycobacterial species are referred to as nontuberculous mycobacteria (NTM), meaning they are not the causative agent of tuberculous (TB) or leprosy, i.e. Read More

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http://dx.doi.org/10.3390/microorganisms7030090DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6463083PMC
March 2019
1 Read

Strong increase of true and false positive mycobacterial cultures sent to the National Reference Centre in Belgium, 2007 to 2016.

Euro Surveill 2019 Mar;24(11)

Unit Bacterial Diseases Service, Infectious diseases in Humans, Sciensano, Brussels, Belgium.

IntroductionIn 2007, a new federal legislation in Belgium prohibited non-biosafety level 3 laboratories to process culture tubes suspected of containing mycobacteria.AimTo present mycobacterial surveillance/diagnosis data from the Belgian National Reference Centre for mycobacteria (NRC) from 2007 to 2016.MethodsThis retrospective observational study investigated the numbers of analyses at the NRC and false positive cultures (interpreted as containing mycobacteria at referring clinical laboratories, but with no mycobacterial DNA detected by PCR in the NRC). Read More

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http://dx.doi.org/10.2807/1560-7917.ES.2019.24.11.1800205DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6425549PMC
March 2019
5 Reads

Multiplex cytokine analysis in Mycobacterium avium complex lung disease: relationship between CXCL10 and poor prognostic factors.

BMC Infect Dis 2019 Mar 18;19(1):263. Epub 2019 Mar 18.

Department of Respiratory Medicine and Infectious Diseases, Niigata University Graduate School of Medical and Dental Sciences, 757 Ichibancho, Asahimachi-dori, Chuo Ward, Niigata City, 951-8510, Japan.

Background: Mycobacterium avium complex lung disease (MAC-LD) can deteriorate rapidly to become fatal. Reported poor prognostic factors include radiographic findings, undernutrition, anemia and high inflammation test values. However, the association of these prognostic factors with the pathophysiology of the disease remains unknown. Read More

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http://dx.doi.org/10.1186/s12879-019-3888-4DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6423821PMC
March 2019
1 Read

Amikacin Liposome Inhalation Suspension: A Review in Mycobacterium avium Complex Lung Disease.

Authors:
Matt Shirley

Drugs 2019 Apr;79(5):555-562

Springer, Private Bag 65901, Mairangi Bay, Auckland, 0754, New Zealand.

Amikacin liposome inhalation suspension (ALIS; Arikayce) [formerly known as liposomal amikacin for inhalation, or LAI] is a liposomal formulation of the aminoglycoside antibacterial drug amikacin. The ALIS formulation, administered via inhalation following nebulization, is designed to facilitate targeted and localized drug delivery to the lungs while minimizing systemic exposure. Based on the prespecified primary endpoint analysis of the ongoing phase III CONVERT trial, ALIS has been approved in the USA for use as part of a combination antibacterial drug regimen against Mycobacterium avium complex (MAC) lung disease that is treatment refractory (i. Read More

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http://dx.doi.org/10.1007/s40265-019-01095-zDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6445814PMC

Comparison of clinical characteristics of patients with Mycobacterium avium complex disease by gender.

Epidemiol Infect 2019 Jan;147:e108

The First Department of Internal Medicine,Shinshu University School of Medicine,Matsumoto, Nagano,Japan.

The clinical characteristics of male patients with pulmonary Mycobacterium avium complex disease have not been clearly defined. We aimed to clarify the clinical characteristics of male patients with pulmonary Mycobacterium avium complex disease compared with female patients.We retrospectively reviewed the medical records of patients with pulmonary Mycobacterium avium complex disease who visited the outpatient clinic of the Shinshu University Hospital between 2003 and 2016 and compared the clinical characteristics of male and female patients. Read More

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http://dx.doi.org/10.1017/S0950268819000293DOI Listing
January 2019
1 Read

Disseminated from a Deep Cutaneous Infection.

Authors:
Adam Stewart

Int J Mycobacteriol 2019 Jan-Mar;8(1):98-100

Department of Infectious Diseases, Sunshine Coast University Hospital, Queensland; Faculty of Medicine, Centre for Clinical Research, The University of Queensland, Royal Brisbane and Women's Hospital Campus, Brisbane, Australia.

Primary cutaneous Mycobacterium avium complex (MAC) infection is a rare diagnosis in both immunocompetent and immunocompromised hosts. Disseminated MAC almost always occurs in the setting of advanced HIV infection and typically results from initial pulmonary or gastrointestinal disease. We describe a case of a 70-year-old female with systemic sclerosis and severe tumoral calcinosis that developed disseminated MAC infection secondary to deep cutaneous disease. Read More

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http://dx.doi.org/10.4103/ijmy.ijmy_17_19DOI Listing
March 2019
3 Reads

BCG Vaccination Induces and Cross-Protective Immunity.

Front Immunol 2019 19;10:234. Epub 2019 Feb 19.

Division of Infectious Diseases, Allergy and Immunology, Department of Internal Medicine, Saint Louis University, St. Louis, MO, United States.

Pulmonary non-tuberculous mycobacterial (NTM) infections particularly caused by complex (MAC) and (MAB) are becoming major health problems in the U.S. New therapies or vaccines which will help prevent the disease, shorten treatment duration and/or increase treatment success rates are urgently needed. Read More

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http://dx.doi.org/10.3389/fimmu.2019.00234DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6389677PMC
February 2019
6 Reads

Specificity of serological test for detection of tuberculosis in cattle, goats, sheep and pigs under different epidemiological situations.

BMC Vet Res 2019 Mar 1;15(1):70. Epub 2019 Mar 1.

Unidad de Inmunología Microbiana, Centro Nacional de Microbiología, Instituto de Salud Carlos III, Majadahonda, Madrid, Spain.

Background: Serum antibody detection has potential as a complementary diagnostic tool in animal tuberculosis (TB) control, particularly in multi-host systems. The objective of the present study was to assess the specificity (Sp) of an enzyme-linked immunosorbent assay (ELISA) based on the new multiprotein complex P22 for the detection of specific antibodies against the Mycobacterium tuberculosis complex (MTC) in the four most relevant domestic animals acting as MTC hosts: cattle, goat, sheep and pig. We used sera from an officially TB-free (OTF) country, Norway, and from a non-OTF one, Spain. Read More

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http://dx.doi.org/10.1186/s12917-019-1814-zDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6397464PMC
March 2019
2 Reads

Comprehensive Comparative Analysis of Cholesterol Catabolic Genes/Proteins in Mycobacterial Species.

Int J Mol Sci 2019 Feb 27;20(5). Epub 2019 Feb 27.

Department of Biochemistry and Microbiology, Faculty of Science and Agriculture, University of Zululand, KwaDlangezwa 3886, South Africa.

In dealing with , the causative agent of the deadliest human disease-tuberculosis (TB)-utilization of cholesterol as a carbon source indicates the possibility of using cholesterol catabolic genes/proteins as novel drug targets. However, studies on cholesterol catabolism in mycobacterial species are scarce, and the number of mycobacterial species utilizing cholesterol as a carbon source is unknown. The availability of a large number of mycobacterial species' genomic data affords an opportunity to explore and predict mycobacterial species' ability to utilize cholesterol employing methods. Read More

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http://dx.doi.org/10.3390/ijms20051032DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6429209PMC
February 2019
3 Reads

Microbiome Diversity in Sputum of Nontuberculous Mycobacteria Infected Women with a History of Breast Cancer.

Cell Physiol Biochem 2019 28;52(2):263-279. Epub 2019 Feb 28.

Department of Cellular and Molecular Biology, The University of Texas Health Science Center at Tyler, Tyler, TX, USA,

Background/aims: The nontuberculous mycobacterial lung disease (NTM), caused by Mycobacterium avium complex (MAC) is an increasing health problem in the USA and worldwide. The NTM disease is prevalent in Caucasian women with a current diagnosis or history of breast cancer (BCa), posing a significant challenge towards treatment. We hypothesize that NTM affected women with considerable therapeutic resistance may harbor pathogenic microbes other than nontuberculous mycobacterium, aiding in disease progression and therapeutic resistance. Read More

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http://dx.doi.org/10.33594/000000020DOI Listing

Unilateral Lung Involvement of Nodular Bronchiectatic Mycobacterium Avium Complex Pulmonary Diseases: Proportion and Evolution on Serial CT Studies.

AJR Am J Roentgenol 2019 Feb 26:1-8. Epub 2019 Feb 26.

2 Department of Medicine, Division of Respiratory and Critical Care Medicine, Samsung Medical Center, Sungkyunkwan University School of Medicine, Seoul, Korea.

Objective: We aimed to explore proportion, involved organisms, and serial CT features of nodular bronchiectatic (NB) Mycobacterium avium complex (MAC) pulmonary diseases that manifested as unilateral lung disease.

Materials And Methods: We retrospectively identified 674 patients with NB MAC pulmonary disease (PD) who underwent serial CT studies from January 2005 through December 2012. We selected patients with unilateral lung involvement as its initial manifestation. Read More

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http://dx.doi.org/10.2214/AJR.18.20589DOI Listing
February 2019
2 Reads

Mycobacterium chimaera Pulmonary Disease in Cystic Fibrosis Patients, France, 2010-2017.

Emerg Infect Dis 2019 Mar;25(3):611-613

We report Mycobacterium chimaera pulmonary disease in 4 patients given a diagnosis of cystic fibrosis in a university hospital in Montpellier, France. All patients had M. chimaera-positive expectorated sputum specimens, clinical symptoms of pulmonary exacerbation, or a decrease in spirometry test results that improved after specific treatment. Read More

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http://dx.doi.org/10.3201/eid2503.181590DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6390743PMC
March 2019
3 Reads

Mycobacterium avium in Community and Household Water, Suburban Philadelphia, Pennsylvania, USA, 2010-2012.

Emerg Infect Dis 2019 Mar;25(3):473-481

Attention to environmental sources of Mycobacterium avium complex (MAC) infection is a vital component of disease prevention and control. We investigated MAC colonization of household plumbing in suburban Philadelphia, Pennsylvania, USA. We used variable-number tandem-repeat genotyping and whole-genome sequencing with core genome single-nucleotide variant analysis to compare M. Read More

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http://dx.doi.org/10.3201/eid2503.180336DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6390762PMC
March 2019
2 Reads

complex infection mimicking lung cancer.

Authors:
Hideharu Hagiya

BMJ Case Rep 2019 Feb 18;12(2). Epub 2019 Feb 18.

Department of General Internal Medicine, Osaka University Hospital, Suita, Osaka, Japan.

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http://dx.doi.org/10.1136/bcr-2018-228847DOI Listing
February 2019

Avian mycobacteriosis in captive brolgas (Antigone rubicunda).

Aust Vet J 2019 Mar 17;97(3):81-86. Epub 2019 Feb 17.

Faculty of Veterinary and Agricultural Sciences, The University of Melbourne, 250 Princes Highway, Werribee, Victoria 3030, Australia.

Case Series: Avian mycobacteriosis is a significant disease of a wide range of bird species worldwide. The most common causative agent, Mycobacterium avium, is reported to also infect a range of mammals, including humans. Of 11 brolgas (Antigone rubicunda) submitted to the University of Melbourne for postmortem examination over a 10-year period, 7 were diagnosed with mycobacteriosis. Read More

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http://dx.doi.org/10.1111/avj.12784DOI Listing
March 2019
1 Read

Pharmaceutical Approval Update.

P T 2019 Jan;44(2):42-44

Arikayce (amikacin liposome inhalation suspension) for complex lung disease; Xofluza (baloxavir marboxil) for acute uncomplicated influenza; and Nuzyra (omadacycline) for community-acquired bacterial pneumonia and/or acute bacterial skin and skin structure infections. Read More

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http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6355053PMC
January 2019

Novel external quality assurance scheme for drug susceptibility testing of non-tuberculous mycobacteria: a multicentre pilot study.

J Antimicrob Chemother 2019 Feb 11. Epub 2019 Feb 11.

National Reference Centre for Mycobacteria, Research Centre Borstel, Leibniz Lung Centre, Borstel, Germany.

Objectives: Our aim was to conduct a multicentre study involving laboratories participating in the European TB Reference Laboratory Network aiming to develop a pilot external quality assessment (EQA) scheme for drug susceptibility testing (DST) of non-tuberculous mycobacteria (NTM).

Methods: The study comprised a survey using a structured questionnaire followed by a pilot EQA round using identical panels of 10 Mycobacterium avium (MAV) and Mycobacterium abscessus (MAB) isolates. EQA results were received from 16 laboratories utilizing the broth microdilution method. Read More

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http://dx.doi.org/10.1093/jac/dkz027DOI Listing
February 2019
2 Reads

Clinical relevance of non-tuberculous mycobacteria isolated from respiratory specimens: seven year experience in a UK hospital.

Sci Rep 2019 Feb 11;9(1):1730. Epub 2019 Feb 11.

Department of Respiratory Medicine, Queen Alexandra Hospital, Southwick Hill Road, Cosham, Portsmouth, PO6 3LY, UK.

The frequency of isolation of non-tuberculous mycobacteria (NTM) species from respiratory specimens is increasing, however the clinical relevance of such identifications vary by mycobacterial species and geographical location. A retrospective study of 853 NTM isolates from respiratory samples from 386 patients over seven years was performed. Clinical records and radiographic information were examined. Read More

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http://dx.doi.org/10.1038/s41598-018-37350-8DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6370870PMC
February 2019
3 Reads

Mycobacterial metabolic characteristics in a water meter biofilm revealed by metagenomics and metatranscriptomics.

Water Res 2019 Apr 31;153:315-323. Epub 2019 Jan 31.

University of Chinese Academy of Sciences, Beijing, China.

Mycobacteria represent one of the most persistent bacterial populations in drinking water distribution system (DWDS) biofilm communities; however, mycobacterial in situ metabolic profiles are largely unknown. In this study, the metabolic characteristics of mycobacteria in a household water meter biofilm were unveiled using a coupled metagenomic/metatranscriptomic approach. The water meter biofilm appeared to express nitrogenase genes (nifDKH) and a full complement of genes coding for several carbon-fixation pathways, especially the Calvin cycle, suggesting the CO sequestration and dinitrogen fixation potential of the biofilm. Read More

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http://dx.doi.org/10.1016/j.watres.2019.01.032DOI Listing

Optimization of In Vitro and Growth Assays for Therapeutic Development.

Microorganisms 2019 Feb 1;7(2). Epub 2019 Feb 1.

Division of Pulmonology, Allergy and Immunology, Department of Pediatrics, Case Western Reserve University School of Medicine, 10900 Euclid Ave. BRB 822, Cleveland, OH 44106, USA.

Infection with nontuberculous mycobacteria (NTM) is a complication of lung disease in immunocompromised patients, including those with human immunodeficiency virus and acquired immune deficiency syndrome (HIV/AIDS), chronic obstructive pulmonary disease (COPD), and cystic fibrosis (CF). The most widespread, disease-causing NTM is complex (), which colonizes the lungs as a combination of , , and other mycobacterial species. While combination drug therapy exists for colonization, there is no cure. Read More

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http://dx.doi.org/10.3390/microorganisms7020042DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6406338PMC
February 2019
2 Reads

New assay to diagnose and differentiate between Mycobacterium tuberculosis complex and nontuberculous mycobacteria.

Tuberculosis (Edinb) 2019 01 9;114:17-23. Epub 2018 Oct 9.

Microbiology Department, Central Tuberculosis Research Institute RAMS, Moscow, Russia.

The purpose of the present study was to create a real-time PCR test system allowing simultaneous detection of nontuberculous mycobacteria (NTM) and Mycobacterium tuberculosis complex (MTBC) both in culture and sputum. NTM cultures (18 strains, 18 species), MTBC cultures (16 strains, 2 species) and non-mycobacterial microorganisms from the collection of the Central Research TB Institute (CTRI) were used for the preliminary evaluation of the test system. 301 NTM cultures from patients with mycobacteriosis were used to assess the sensitivity of the developed test system. Read More

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https://linkinghub.elsevier.com/retrieve/pii/S14729792183013
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http://dx.doi.org/10.1016/j.tube.2018.10.004DOI Listing
January 2019
8 Reads

Isolation of Nontuberculous Mycobacteria in Southeast Asian and African Human Immunodeficiency Virus-infected Children With Suspected Tuberculosis.

Clin Infect Dis 2019 Jan 28. Epub 2019 Jan 28.

Epidemiology and Public Health Unit, Institut Pasteur du Cambodge, Phnom Penh, Cambodia.

We enrolled 427 human immunodeficiency virus-infected children (median age, 7.3 years), 59.2% severely immunodeficient, with suspected tuberculosis in Southeast Asian and African settings. Read More

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http://dx.doi.org/10.1093/cid/ciy897DOI Listing
January 2019
3 Reads

Multicenter evaluation of the biochip assay for rapid detection of mycobacterial isolates in smear-positive specimens.

Int J Infect Dis 2019 Apr 24;81:46-51. Epub 2019 Jan 24.

State Key Laboratory for Diagnosis and Treatment of Infectious Diseases, Collaborative Innovation Center for Diagnosis and Treatment of Infectious Diseases, The First Affiliated Hospital, College of Medicine, Zhejiang University, No. 79 Qingchun Road, Shangcheng District, Hangzhou 310003, Zhejiang, China. Electronic address:

Objectives: The objective of this study was to conduct a multicentre evaluation of the performance of the biochip assay in the rapid identification of mycobacteria in smear-positive sputum specimens.

Methods: A total of 1751 sputum specimens were obtained from 7 cities in Zhejiang, China. All of the specimens were used for the discrimination of Mycobacterium species using the biochip assay, and the results were compared to the golden standard method of culture, hsp65, 16S rRNA and rpoB sequence analysis. Read More

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http://dx.doi.org/10.1016/j.ijid.2019.01.036DOI Listing
April 2019
7 Reads

Nontuberculous mycobacterial infection after lung transplantation: a report of four cases.

Surg Case Rep 2019 Jan 23;5(1):11. Epub 2019 Jan 23.

Department of General Thoracic Surgery, Osaka University Graduate School of Medicine, 2-2 Yamadaoka, Suita-shi, Osaka, Japan.

Background: Nontuberculous mycobacterium (NTM) infection in a patient in an immunosuppressed state caused by increased use of immunosuppressive or biological agents is a serious clinical problem. Mycobacterium avium complex is the most common involved pathogen, followed by Mycobacterium abscessus (MABSC), while Mycobacterium kansasii is not a major concern. The rate of infection rate in lung transplant recipients is reported to range from 1. Read More

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http://dx.doi.org/10.1186/s40792-019-0565-1DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6346695PMC
January 2019
3 Reads

Mycobacterium avium paratuberculosis and Mycobacterium avium complex and related subspecies as causative agents of zoonotic and occupational diseases.

J Cell Physiol 2019 Aug 23;234(8):12415-12421. Epub 2019 Jan 23.

Social Determinants of Health Research Center, Shahrekord University of Medical Sciences, Shahrekord, Iran.

Mycobacterium avium complex (MAC) and Mycobacterium avium paratuberculosis (MAP) cause zoonotic infections transmitted by birds and livestock herds. These pathogens have remained as serious economic and health threats in most areas of the world. As zoonotic diseases, the risk of development of occupational disease and even death outcome necessitate implementation of control strategies to prevent its spread. Read More

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http://doi.wiley.com/10.1002/jcp.28076
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http://dx.doi.org/10.1002/jcp.28076DOI Listing
August 2019
8 Reads

An evaluation of methods for the isolation of nontuberculous mycobacteria from patients with cystic fibrosis, bronchiectasis and patients assessed for lung transplantation.

BMC Pulm Med 2019 Jan 21;19(1):19. Epub 2019 Jan 21.

Microbiology Department, Freeman Hospital, Newcastle upon Tyne, NE7 7DN, UK.

Background: RGM medium is an agar-based, selective culture medium designed for the isolation of nontuberculous mycobacteria (NTM) from the sputum of patients with cystic fibrosis (CF). We evaluated RGM medium for the detection of NTM in patients with CF (405 samples), bronchiectasis (323 samples) and other lung diseases necessitating lung transplantation (274 samples).

Methods: In total, 1002 respiratory samples from 676 patients were included in the study. Read More

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http://dx.doi.org/10.1186/s12890-019-0781-2DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6341538PMC
January 2019
5 Reads

Clinical Characteristics and Etiologies of Miliary Nodules in the US: A Single-Center Study.

Am J Med 2019 Jan 16. Epub 2019 Jan 16.

Divisions of Critical Care, Pulmonary and Sleep Medicine, Department of Internal Medicine. Electronic address:

Background: Miliary nodules have been typically described as a radiological manifestation of disseminated tuberculosis. However, miliary nodules are known to occur in a wide variety of conditions. The primary objective of the study was to identify clinical characteristics and etiologies of miliary nodules within our institution. Read More

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http://dx.doi.org/10.1016/j.amjmed.2018.12.030DOI Listing
January 2019
4 Reads

A young boy with disseminated Mycobacterium avium complex infection.

Int J Infect Dis 2019 Apr 15;81:10-11. Epub 2019 Jan 15.

Department of Infectious Diseases, Huashan Hospital, Fudan University, Shanghai, China. Electronic address:

The case of a Chinese boy with no medical history, who presented with diarrhea and weight loss of 14-month duration and rashes and fever or 6-month duration, is described. The patient was finally diagnosed with disseminated Mycobacterium avium complex infection by skin biopsy and tissue culture. This case shows that Mycobacterium avium complex infection should be considered even in an immunocompetent patient with diarrhea and skin lesions. Read More

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https://linkinghub.elsevier.com/retrieve/pii/S12019712193002
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http://dx.doi.org/10.1016/j.ijid.2019.01.016DOI Listing
April 2019
10 Reads

A bedaquiline/clofazimine combination regimen might add activity to the treatment of clinically relevant non-tuberculous mycobacteria.

J Antimicrob Chemother 2019 Apr;74(4):935-943

Department of Medical Microbiology, Radboud University Medical Center, Nijmegen, The Netherlands.

Background: Non-tuberculous mycobacteria (NTM) infections are hard to treat. New antimicrobial drugs and smarter combination regimens are needed.

Objectives: Our aim was to determine the in vitro activity of bedaquiline against NTM and assess its synergy with established antimycobacterials. Read More

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http://dx.doi.org/10.1093/jac/dky526DOI Listing
April 2019
5 Reads
5.313 Impact Factor

Genetic Variation/Evolution and Differential Host Responses Resulting from In-Patient Adaptation of .

Infect Immun 2019 Apr 25;87(4). Epub 2019 Mar 25.

Centre of Molecular Inflammation Research (CEMIR), Norwegian University of Science and Technology (NTNU), Trondheim, Norway

Members of the complex (MAC) are characterized as nontuberculosis mycobacteria and are pathogenic mainly in immunocompromised individuals. MAC strains show a wide genetic variability, and there is growing evidence suggesting that genetic differences may contribute to a varied immune response that may impact the infection outcome. The current study aimed to characterize the genomic changes within isolates collected from single patients over time and test the host immune responses to these clinical isolates. Read More

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http://iai.asm.org/lookup/doi/10.1128/IAI.00323-18
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http://dx.doi.org/10.1128/IAI.00323-18DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6434124PMC
April 2019
10 Reads

Tuberculosis and atypical mycobacterial infections in ruxolitinib-treated patients with primary or secondary myelofibrosis or polycythemia vera.

Int J Infect Dis 2019 Mar 11;80:134-136. Epub 2019 Jan 11.

Department of Oncology and Haematology, Hôpitaux Universitaires de Strasbourg, Strasbourg, France; Université de Strasbourg, Inserm UMR-S1113/IRFAC, Strasbourg, France.

Ruxolitinib is a JAK-1/JAK-2 inhibitor indicated for the treatment of polycythemia vera and primary or secondary myelofibrosis. Only one patient (0.2%) was diagnosed with tuberculosis among the 485 patients receiving ruxolitinib in the four pivotal trials. Read More

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https://linkinghub.elsevier.com/retrieve/pii/S12019712193001
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http://dx.doi.org/10.1016/j.ijid.2019.01.002DOI Listing
March 2019
16 Reads

Marker genes of fecal indicator bacteria and potential pathogens in animal feces in subtropical catchments.

Sci Total Environ 2019 Mar 29;656:1427-1435. Epub 2018 Nov 29.

GeneCology Research Centre, Faculty of Science, Health, Education and Engineering, University of the Sunshine Coast, Maroochydore, QLD 4558, Australia.

We investigated the abundance of marker genes of two fecal indicator bacteria (FIB) and eight potential pathogens in fecal samples of humans (n = 14) and 10 domestic and native wild animals (n = 134). For each target animal, between 10 and 14 individual fecal samples were collected (n = 148 individual fecal samples in total). The abundance of FIB and potential pathogens within each sample was determined using quantitative PCR (qPCR) assays. Read More

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http://dx.doi.org/10.1016/j.scitotenv.2018.11.439DOI Listing

Evaluation of a Novel MALDI Biotyper Algorithm to Distinguish From .

Front Microbiol 2018 18;9:3140. Epub 2018 Dec 18.

Mycobacteriology Laboratory, National Jewish Health, Denver, CO, United States.

Accurate and timely mycobacterial species identification is imperative for successful diagnosis, treatment, and management of disease caused by nontuberculous mycobacteria (NTM). The current most widely utilized method for NTM species identification is Sanger sequencing of one or more genomic loci, followed by BLAST sequence analysis. MALDI-TOF MS offers a less expensive and increasingly accurate alternative to sequencing, but the commercially available assays used in clinical mycobacteriology cannot differentiate between and , two closely related potentially pathogenic species of NTM that are members of the complex (MAC). Read More

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https://www.frontiersin.org/article/10.3389/fmicb.2018.03140
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http://dx.doi.org/10.3389/fmicb.2018.03140DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6305299PMC
December 2018
12 Reads

Biosynthesis of mycobacterial methylmannose polysaccharides requires a unique 1--methyltransferase specific for 3--methylated mannosides.

Proc Natl Acad Sci U S A 2019 01 3;116(3):835-844. Epub 2019 Jan 3.

Center for Neuroscience and Cell Biology (CNC), University of Coimbra, 3004-504 Coimbra, Portugal;

Mycobacteria are a wide group of organisms that includes strict pathogens, such as , as well as environmental species known as nontuberculous mycobacteria (NTM), some of which-namely -are important opportunistic pathogens. In addition to a distinctive cell envelope mediating critical interactions with the host immune system and largely responsible for their formidable resistance to antimicrobials, mycobacteria synthesize rare intracellular polymethylated polysaccharides implicated in the modulation of fatty acid metabolism, thus critical players in cell envelope assembly. These are the 6--methylglucose lipopolysaccharides (MGLP) ubiquitously detected across the genus, and the 3--methylmannose polysaccharides (MMP) identified only in NTM. Read More

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http://dx.doi.org/10.1073/pnas.1813450116DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6338870PMC
January 2019
2 Reads

Adverse reactions associated with long-term drug administration in complex lung disease.

Int J Tuberc Lung Dis 2018 Dec;22(12):1505-1510

Centre for Pulmonary Diseases, National Hospital Organization Tokyo National Hospital, Tokyo, Japan.

Setting: The number of patients with non-tuberculous mycobacterial lung disease (NTM-LD) worldwide has been increasing. complex lung disease (MAC-LD) accounts for 90% of NTM-LD. MAC-LD necessitates long-term treatment, but adverse reactions with long-term administration of drugs are poorly understood. Read More

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http://dx.doi.org/10.5588/ijtld.18.0171DOI Listing
December 2018
4 Reads

Complex Infection-Related Immune Reconstitution Inflammatory Syndrome Mimicking Lymphoma in an Human Immunodeficiency Virus-Infected Patient.

Infect Chemother 2018 Dec;50(4):350-356

Division of Infectious Diseases, Department of Internal Medicine, Gil Medical Center, Gachon University College of Medicine, Incheon, Korea.

In acquired immunodeficiency syndrome (AIDS) patients, immune reconstitution inflammatory syndrome (IRIS) due to complex (MAC) infection is one of the most difficult IRIS types to manage. We report an unusual case of MAC-associated IRIS. At first the patient was diagnosed human immunodeficiency virus (HIV) infection after he was admitted with pneumocystis pneumonia. Read More

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http://dx.doi.org/10.3947/ic.2018.50.4.350DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6312901PMC
December 2018

Development of lung cancer in patients with nontuberculous mycobacterial lung disease.

Respir Investig 2019 Mar 28;57(2):157-164. Epub 2018 Dec 28.

Center for Infectious Diseases and Infection Control, Keio University School of Medicine, Japan. Electronic address:

Background: As lung cancer development in patients with nontuberculous mycobacterial lung disease (NTM-LD) has never been reported, we investigated its incidence and clinical characteristics.

Methods: Prospective observational cohort registry (from June 2012 to June 2017), and retrospective identification by the International Classification of Diseases, tenth revision (between March 2010 and March 2018), were used to identify NTM-LD patients aged ≥20 years who developed lung cancer.

Results: Eight patients (two men and six women, one with smoking history), having Mycobacterium avium complex lung disease (MAC-LD) were identified. Read More

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http://dx.doi.org/10.1016/j.resinv.2018.11.004DOI Listing

New Antibiotic Approved for Refractory Mycobacterium Avium Complex.

Am J Nurs 2019 Jan;119(1):26

Diane S. Aschenbrenner is an assistant professor at Notre Dame of Maryland University in Baltimore. She also coordinates Drug Watch:

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http://dx.doi.org/10.1097/01.NAJ.0000552604.35664.f5DOI Listing
January 2019