6,657 results match your criteria Mycobacterium Avium-Intracellulare


Pharmaceutical Approval Update.

P T 2019 Jan;44(2):42-44

Arikayce (amikacin liposome inhalation suspension) for complex lung disease; Xofluza (baloxavir marboxil) for acute uncomplicated influenza; and Nuzyra (omadacycline) for community-acquired bacterial pneumonia and/or acute bacterial skin and skin structure infections. Read More

View Article

Download full-text PDF

Source
January 2019

Novel external quality assurance scheme for drug susceptibility testing of non-tuberculous mycobacteria: a multicentre pilot study.

J Antimicrob Chemother 2019 Feb 11. Epub 2019 Feb 11.

National Reference Centre for Mycobacteria, Research Centre Borstel, Leibniz Lung Centre, Borstel, Germany.

Objectives: Our aim was to conduct a multicentre study involving laboratories participating in the European TB Reference Laboratory Network aiming to develop a pilot external quality assessment (EQA) scheme for drug susceptibility testing (DST) of non-tuberculous mycobacteria (NTM).

Methods: The study comprised a survey using a structured questionnaire followed by a pilot EQA round using identical panels of 10 Mycobacterium avium (MAV) and Mycobacterium abscessus (MAB) isolates. EQA results were received from 16 laboratories utilizing the broth microdilution method. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1093/jac/dkz027DOI Listing
February 2019
1 Read

Clinical relevance of non-tuberculous mycobacteria isolated from respiratory specimens: seven year experience in a UK hospital.

Sci Rep 2019 Feb 11;9(1):1730. Epub 2019 Feb 11.

Department of Respiratory Medicine, Queen Alexandra Hospital, Southwick Hill Road, Cosham, Portsmouth, PO6 3LY, UK.

The frequency of isolation of non-tuberculous mycobacteria (NTM) species from respiratory specimens is increasing, however the clinical relevance of such identifications vary by mycobacterial species and geographical location. A retrospective study of 853 NTM isolates from respiratory samples from 386 patients over seven years was performed. Clinical records and radiographic information were examined. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1038/s41598-018-37350-8DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6370870PMC
February 2019

Mycobacterial metabolic characteristics in a water meter biofilm revealed by metagenomics and metatranscriptomics.

Water Res 2019 Apr 31;153:315-323. Epub 2019 Jan 31.

University of Chinese Academy of Sciences, Beijing, China.

Mycobacteria represent one of the most persistent bacterial populations in drinking water distribution system (DWDS) biofilm communities; however, mycobacterial in situ metabolic profiles are largely unknown. In this study, the metabolic characteristics of mycobacteria in a household water meter biofilm were unveiled using a coupled metagenomic/metatranscriptomic approach. The water meter biofilm appeared to express nitrogenase genes (nifDKH) and a full complement of genes coding for several carbon-fixation pathways, especially the Calvin cycle, suggesting the CO sequestration and dinitrogen fixation potential of the biofilm. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1016/j.watres.2019.01.032DOI Listing

Optimization of In Vitro and Growth Assays for Therapeutic Development.

Microorganisms 2019 Feb 1;7(2). Epub 2019 Feb 1.

Division of Pulmonology, Allergy and Immunology, Department of Pediatrics, Case Western Reserve University School of Medicine, 10900 Euclid Ave. BRB 822, Cleveland, OH 44106, USA.

Infection with nontuberculous mycobacteria (NTM) is a complication of lung disease in immunocompromised patients, including those with human immunodeficiency virus and acquired immune deficiency syndrome (HIV/AIDS), chronic obstructive pulmonary disease (COPD), and cystic fibrosis (CF). The most widespread, disease-causing NTM is complex (), which colonizes the lungs as a combination of , , and other mycobacterial species. While combination drug therapy exists for colonization, there is no cure. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.3390/microorganisms7020042DOI Listing
February 2019
1 Read

New assay to diagnose and differentiate between Mycobacterium tuberculosis complex and nontuberculous mycobacteria.

Tuberculosis (Edinb) 2019 01 9;114:17-23. Epub 2018 Oct 9.

Microbiology Department, Central Tuberculosis Research Institute RAMS, Moscow, Russia.

The purpose of the present study was to create a real-time PCR test system allowing simultaneous detection of nontuberculous mycobacteria (NTM) and Mycobacterium tuberculosis complex (MTBC) both in culture and sputum. NTM cultures (18 strains, 18 species), MTBC cultures (16 strains, 2 species) and non-mycobacterial microorganisms from the collection of the Central Research TB Institute (CTRI) were used for the preliminary evaluation of the test system. 301 NTM cultures from patients with mycobacteriosis were used to assess the sensitivity of the developed test system. Read More

View Article

Download full-text PDF

Source
https://linkinghub.elsevier.com/retrieve/pii/S14729792183013
Publisher Site
http://dx.doi.org/10.1016/j.tube.2018.10.004DOI Listing
January 2019
2 Reads

Isolation of Nontuberculous Mycobacteria in Southeast Asian and African Human Immunodeficiency Virus-infected Children With Suspected Tuberculosis.

Clin Infect Dis 2019 Jan 28. Epub 2019 Jan 28.

Epidemiology and Public Health Unit, Institut Pasteur du Cambodge, Phnom Penh, Cambodia.

We enrolled 427 human immunodeficiency virus-infected children (median age, 7.3 years), 59.2% severely immunodeficient, with suspected tuberculosis in Southeast Asian and African settings. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1093/cid/ciy897DOI Listing
January 2019

Multicenter Evaluation of the Biochip Assay for Rapid Detection of Mycobacterial Isolates in Smear-Positive Specimens.

Int J Infect Dis 2019 Jan 24. Epub 2019 Jan 24.

State Key Laboratory for Diagnosis and Treatment of Infectious Diseases, Collaborative Innovation Center for Diagnosis and Treatment of Infectious Diseases, The First Affiliated Hospital, College of Medicine, Zhejiang University, No. 79 Qingchun Road, Hangzhou 310003, Zhejiang Province, China. Electronic address:

Objectives: The objective of this study was to conduct a multicentre evaluation of the performance of the biochip assay in the rapid identification of mycobacteria in smear-positive sputum specimens.

Methods: A total of 1751 sputum specimens were obtained from 7 cities in Zhejiang, China. All of the specimens were used for the discrimination of Mycobacterium species using the biochip assay, and the results were compared to the golden standard method of culture, hsp65, 16S rRNA and rpoB sequence analysis. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1016/j.ijid.2019.01.036DOI Listing
January 2019
2 Reads

Nontuberculous mycobacterial infection after lung transplantation: a report of four cases.

Surg Case Rep 2019 Jan 23;5(1):11. Epub 2019 Jan 23.

Department of General Thoracic Surgery, Osaka University Graduate School of Medicine, 2-2 Yamadaoka, Suita-shi, Osaka, Japan.

Background: Nontuberculous mycobacterium (NTM) infection in a patient in an immunosuppressed state caused by increased use of immunosuppressive or biological agents is a serious clinical problem. Mycobacterium avium complex is the most common involved pathogen, followed by Mycobacterium abscessus (MABSC), while Mycobacterium kansasii is not a major concern. The rate of infection rate in lung transplant recipients is reported to range from 1. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1186/s40792-019-0565-1DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6346695PMC
January 2019
2 Reads

Mycobacterium avium paratuberculosis and Mycobacterium avium complex and related subspecies as causative agents of zoonotic and occupational diseases.

J Cell Physiol 2019 Jan 23. Epub 2019 Jan 23.

Social Determinants of Health Research Center, Shahrekord University of Medical Sciences, Shahrekord, Iran.

Mycobacterium avium complex (MAC) and Mycobacterium avium paratuberculosis (MAP) cause zoonotic infections transmitted by birds and livestock herds. These pathogens have remained as serious economic and health threats in most areas of the world. As zoonotic diseases, the risk of development of occupational disease and even death outcome necessitate implementation of control strategies to prevent its spread. Read More

View Article

Download full-text PDF

Source
http://doi.wiley.com/10.1002/jcp.28076
Publisher Site
http://dx.doi.org/10.1002/jcp.28076DOI Listing
January 2019
4 Reads

An evaluation of methods for the isolation of nontuberculous mycobacteria from patients with cystic fibrosis, bronchiectasis and patients assessed for lung transplantation.

BMC Pulm Med 2019 Jan 21;19(1):19. Epub 2019 Jan 21.

Microbiology Department, Freeman Hospital, Newcastle upon Tyne, NE7 7DN, UK.

Background: RGM medium is an agar-based, selective culture medium designed for the isolation of nontuberculous mycobacteria (NTM) from the sputum of patients with cystic fibrosis (CF). We evaluated RGM medium for the detection of NTM in patients with CF (405 samples), bronchiectasis (323 samples) and other lung diseases necessitating lung transplantation (274 samples).

Methods: In total, 1002 respiratory samples from 676 patients were included in the study. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1186/s12890-019-0781-2DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6341538PMC
January 2019
3 Reads

Clinical Characteristics and Etiologies of Miliary Nodules in the US: A Single-Center Study.

Am J Med 2019 Jan 16. Epub 2019 Jan 16.

Divisions of Critical Care, Pulmonary and Sleep Medicine, Department of Internal Medicine. Electronic address:

Background: Miliary nodules have been typically described as a radiological manifestation of disseminated tuberculosis. However, miliary nodules are known to occur in a wide variety of conditions. The primary objective of the study was to identify clinical characteristics and etiologies of miliary nodules within our institution. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1016/j.amjmed.2018.12.030DOI Listing
January 2019
2 Reads

A Yong Boy with Disseminated Mycobacterium Avium Complex Infection.

Int J Infect Dis 2019 Jan 15. Epub 2019 Jan 15.

Department of Infectious Diseases, Huashan Hospital, Fudan University. Electronic address:

Here we describe a chinese boy with no medical history presented with diarrhea and weight loss for 14 months and rashes and fever for 6 months. The patient was finally diagnosed with Disseminated Mycobacterium Avium Complex Infection by skin biopsy and tissue culture. This case highlights that mycobacterium avium complex infection should be considered even in an immunocompetent patient with diarrhea and skin lesions. Read More

View Article

Download full-text PDF

Source
https://linkinghub.elsevier.com/retrieve/pii/S12019712193002
Publisher Site
http://dx.doi.org/10.1016/j.ijid.2019.01.016DOI Listing
January 2019
5 Reads

A bedaquiline/clofazimine combination regimen might add activity to the treatment of clinically relevant non-tuberculous mycobacteria.

J Antimicrob Chemother 2019 Jan 10. Epub 2019 Jan 10.

Department of Medical Microbiology, Radboud University Medical Center, Nijmegen, The Netherlands.

Background: Non-tuberculous mycobacteria (NTM) infections are hard to treat. New antimicrobial drugs and smarter combination regimens are needed.

Objectives: Our aim was to determine the in vitro activity of bedaquiline against NTM and assess its synergy with established antimycobacterials. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1093/jac/dky526DOI Listing
January 2019
2 Reads
5.313 Impact Factor

Genetic variation/evolution and differential host responses resulting from in-patient adaptation of .

Infect Immun 2019 Jan 14. Epub 2019 Jan 14.

Centre of Molecular Inflammation Research (CEMIR), Department of Clinical and Molecular Medicine, Norwegian University of Science and Technology (NTNU), Trondheim, Norway

(Mav) complex (MAC) are characterized as non-tuberculosis mycobacteria and are pathogenic mainly in immunocompromised individuals. MAC strains show a wide genetic variability, and there is growing evidence suggesting that genetic differences may contribute to a varied immune response that may impact on the infection outcome. The current study aimed to characterize the genomic changes within Mav isolates collected from single patients over time and test the host immune responses to these clinical isolates. Read More

View Article

Download full-text PDF

Source
http://iai.asm.org/lookup/doi/10.1128/IAI.00323-18
Publisher Site
http://dx.doi.org/10.1128/IAI.00323-18DOI Listing
January 2019
3 Reads

Tuberculosis and atypical mycobacterial infections in ruxolitinib-treated patients with primary or secondary myelofibrosis or polycythemia vera.

Int J Infect Dis 2019 Jan 11;80:134-136. Epub 2019 Jan 11.

Department of Oncology and Haematology, Hôpitaux Universitaires de Strasbourg, Strasbourg, France; Université de Strasbourg, Inserm UMR-S1113/IRFAC, Strasbourg, France.

Ruxolitinib is a JAK-1/JAK-2 inhibitor indicated for the treatment of polycythemia vera and primary or secondary myelofibrosis. Only one patient (0.2%) was diagnosed with tuberculosis among the 485 patients receiving ruxolitinib in the four pivotal trials. Read More

View Article

Download full-text PDF

Source
https://linkinghub.elsevier.com/retrieve/pii/S12019712193001
Publisher Site
http://dx.doi.org/10.1016/j.ijid.2019.01.002DOI Listing
January 2019
8 Reads

Marker genes of fecal indicator bacteria and potential pathogens in animal feces in subtropical catchments.

Sci Total Environ 2019 Mar 29;656:1427-1435. Epub 2018 Nov 29.

GeneCology Research Centre, Faculty of Science, Health, Education and Engineering, University of the Sunshine Coast, Maroochydore, QLD 4558, Australia.

We investigated the abundance of marker genes of two fecal indicator bacteria (FIB) and eight potential pathogens in fecal samples of humans (n = 14) and 10 domestic and native wild animals (n = 134). For each target animal, between 10 and 14 individual fecal samples were collected (n = 148 individual fecal samples in total). The abundance of FIB and potential pathogens within each sample was determined using quantitative PCR (qPCR) assays. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1016/j.scitotenv.2018.11.439DOI Listing

Evaluation of a Novel MALDI Biotyper Algorithm to Distinguish From .

Front Microbiol 2018 18;9:3140. Epub 2018 Dec 18.

Mycobacteriology Laboratory, National Jewish Health, Denver, CO, United States.

Accurate and timely mycobacterial species identification is imperative for successful diagnosis, treatment, and management of disease caused by nontuberculous mycobacteria (NTM). The current most widely utilized method for NTM species identification is Sanger sequencing of one or more genomic loci, followed by BLAST sequence analysis. MALDI-TOF MS offers a less expensive and increasingly accurate alternative to sequencing, but the commercially available assays used in clinical mycobacteriology cannot differentiate between and , two closely related potentially pathogenic species of NTM that are members of the complex (MAC). Read More

View Article

Download full-text PDF

Source
https://www.frontiersin.org/article/10.3389/fmicb.2018.03140
Publisher Site
http://dx.doi.org/10.3389/fmicb.2018.03140DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6305299PMC
December 2018
7 Reads

Biosynthesis of mycobacterial methylmannose polysaccharides requires a unique 1--methyltransferase specific for 3--methylated mannosides.

Proc Natl Acad Sci U S A 2019 Jan 3;116(3):835-844. Epub 2019 Jan 3.

Center for Neuroscience and Cell Biology (CNC), University of Coimbra, 3004-504 Coimbra, Portugal;

Mycobacteria are a wide group of organisms that includes strict pathogens, such as , as well as environmental species known as nontuberculous mycobacteria (NTM), some of which-namely -are important opportunistic pathogens. In addition to a distinctive cell envelope mediating critical interactions with the host immune system and largely responsible for their formidable resistance to antimicrobials, mycobacteria synthesize rare intracellular polymethylated polysaccharides implicated in the modulation of fatty acid metabolism, thus critical players in cell envelope assembly. These are the 6--methylglucose lipopolysaccharides (MGLP) ubiquitously detected across the genus, and the 3--methylmannose polysaccharides (MMP) identified only in NTM. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1073/pnas.1813450116DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6338870PMC
January 2019
2 Reads

Adverse reactions associated with long-term drug administration in complex lung disease.

Int J Tuberc Lung Dis 2018 Dec;22(12):1505-1510

Centre for Pulmonary Diseases, National Hospital Organization Tokyo National Hospital, Tokyo, Japan.

Setting: The number of patients with non-tuberculous mycobacterial lung disease (NTM-LD) worldwide has been increasing. complex lung disease (MAC-LD) accounts for 90% of NTM-LD. MAC-LD necessitates long-term treatment, but adverse reactions with long-term administration of drugs are poorly understood. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.5588/ijtld.18.0171DOI Listing
December 2018
2 Reads

Complex Infection-Related Immune Reconstitution Inflammatory Syndrome Mimicking Lymphoma in an Human Immunodeficiency Virus-Infected Patient.

Infect Chemother 2018 Dec;50(4):350-356

Division of Infectious Diseases, Department of Internal Medicine, Gil Medical Center, Gachon University College of Medicine, Incheon, Korea.

In acquired immunodeficiency syndrome (AIDS) patients, immune reconstitution inflammatory syndrome (IRIS) due to complex (MAC) infection is one of the most difficult IRIS types to manage. We report an unusual case of MAC-associated IRIS. At first the patient was diagnosed human immunodeficiency virus (HIV) infection after he was admitted with pneumocystis pneumonia. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.3947/ic.2018.50.4.350DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6312901PMC
December 2018

Development of lung cancer in patients with nontuberculous mycobacterial lung disease.

Respir Investig 2018 Dec 28. Epub 2018 Dec 28.

Center for Infectious Diseases and Infection Control, Keio University School of Medicine, Japan. Electronic address:

Background: As lung cancer development in patients with nontuberculous mycobacterial lung disease (NTM-LD) has never been reported, we investigated its incidence and clinical characteristics.

Methods: Prospective observational cohort registry (from June 2012 to June 2017), and retrospective identification by the International Classification of Diseases, tenth revision (between March 2010 and March 2018), were used to identify NTM-LD patients aged ≥20 years who developed lung cancer.

Results: Eight patients (two men and six women, one with smoking history), having Mycobacterium avium complex lung disease (MAC-LD) were identified. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1016/j.resinv.2018.11.004DOI Listing
December 2018

New Antibiotic Approved for Refractory Mycobacterium Avium Complex.

Am J Nurs 2019 Jan;119(1):26

Diane S. Aschenbrenner is an assistant professor at Notre Dame of Maryland University in Baltimore. She also coordinates Drug Watch:

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1097/01.NAJ.0000552604.35664.f5DOI Listing
January 2019

Case 40-2018: A 47-Year-Old Woman with Recurrent Sinusitis, Cough, and Bronchiectasis.

N Engl J Med 2018 Dec;379(26):2558-2565

From the Departments of Medicine (J.E.M., C.J.R.), Radiology (J.S.H.), and Pathology (L.P.H.), Massachusetts General Hospital, and the Departments of Medicine (J.E.M., C.J.R.), Radiology (J.S.H.), and Pathology (L.P.H.), Harvard Medical School - both in Boston.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1056/NEJMcpc1810388DOI Listing
December 2018
2 Reads

Genetic mutations in linezolid-resistant Mycobacterium avium complex and Mycobacterium abscessus clinical isolates.

Diagn Microbiol Infect Dis 2018 Nov 30. Epub 2018 Nov 30.

Division of Pulmonary and Critical Care Medicine, Department of Medicine, Samsung Medical Center, Sungkyunkwan University School of Medicine, Seoul, South Korea. Electronic address:

There are no studies evaluating the mechanisms driving linezolid resistance in nontuberculous mycobacteria. The novel mutations G2599A and A2137T in the 23S rRNA gene and mutations A439G and G443A in the rplD gene associated with linezolid resistance were identified in linezolid-resistant M. avium complex isolates. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1016/j.diagmicrobio.2018.10.022DOI Listing
November 2018
2 Reads

Genitourinary Tract Infection Due to Mycobacterium avium intracellulare Complex Infection in Pretransplant Setting With Recurrence Following Transplant: A Case Report.

Transplant Proc 2018 Dec 8;50(10):3937-3939. Epub 2018 Sep 8.

Program in Adult Transplant Infectious Disease, Division of Infectious Disease and International Medicine, Department of Medicine, University of Minnesota, Minneapolis, Minnesota.

Genitourinary (GU) tract infection with Mycobacterium avium intracellulare complex (MAI) is very rare and, to our knowledge, has never been reported in the solid organ transplant literature. CASE DESCRIPTION: A 61-year-old Somali-born woman had a history of liver cirrhosis due to chronic hepatitis C infection. She was diagnosed as having and treated for latent tuberculosis infection and GU tract infection due to MAI. Read More

View Article

Download full-text PDF

Source
https://linkinghub.elsevier.com/retrieve/pii/S00411345183116
Publisher Site
http://dx.doi.org/10.1016/j.transproceed.2018.09.007DOI Listing
December 2018
12 Reads

Treatment of Complex Pulmonary Disease.

Tuberc Respir Dis (Seoul) 2019 Jan;82(1):15-26

Division of Mycobacterial and Respiratory Infections, National Jewish Health, Denver, CO, USA.

The pathogen complex (MAC) is the most common cause of nontuberculous mycobacterial pulmonary disease worldwide. The decision to initiate long-term antibiotic treatment is difficult for the physician due to inconsistent disease progression and adverse effects associated with the antibiotic treatment. The prognostic factors for the progression of MAC pulmonary disease are low body mass index, poor nutritional status, presence of cavitary lesion(s), extensive disease, and a positive acid-fast bacilli smear. Read More

View Article

Download full-text PDF

Source
https://synapse.koreamed.org/DOIx.php?id=10.4046/trd.2018.00
Publisher Site
http://dx.doi.org/10.4046/trd.2018.0060DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6304322PMC
January 2019
1 Read

[Hypersensitivity pneumonitis and abscess reaction to nontuberculous mycobacteria acquired form jacuzzi aerosol].

Rev Mal Respir 2019 Jan 17;36(1):57-62. Epub 2018 Dec 17.

Université François Rabelais, Inserm U1100, faculté de médecine de Tours, 37000 Tours, France.

Introduction: Mycobacterium avium complex can be responsible for a number of different radio-clinical presentations, ranging from invasive infections to hypersensitivity pneumonitis due to repeated inhalation of antigens. The diagnosis of hypersensitivity pneumonitis is clinical, radiological, biological and microbiological.

Case Report: A 61-year-old male developed a hypersensitivity pneumonitis reaction to non-tuberculous mycobacteria, following the repeated use of his own spa, which later evolved into chronic respiratory failure. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1016/j.rmr.2017.10.670DOI Listing
January 2019
1 Read

Host Variability in NTM Disease: Implications for Research Needs.

Front Microbiol 2018 3;9:2901. Epub 2018 Dec 3.

Laboratory of Chronic Airway Infection, Pulmonary Branch, Division of Intramural Research, National Heart, Lung, and Blood Institute, National Institutes of Health, Bethesda, MD, United States.

Non-tuberculous mycobacteria (NTM) are ubiquitous environmental organisms that may cause opportunistic infections in susceptible hosts. Lung infections in immunocompetent persons with structural lung disease are most common, while disseminated disease occurs primarily in immunocompromised individuals. Human disease caused by certain species, such as complex, , and , is increasing in incidence and varies by geographic distribution. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.3389/fmicb.2018.02901DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6286975PMC
December 2018
1 Read

Effect of Macrolide Prophylactic Therapy on AIDS-Defining Conditions and HIV-Associated Mortality.

J Acquir Immune Defic Syndr 2018 Dec 10. Epub 2018 Dec 10.

Research Institute for Tropical Medicine, Muntinlupa City, Philippines.

Background: Mycobacterium avium complex (MAC) prophylaxis is recommended for patients with advanced HIV infection. With the decrease in incidence of disseminated MAC infection and the availability of antiretroviral therapy (ART), the benefits of macrolide prophylaxis were investigated. This study examined the impact of macrolide prophylaxis on AIDS-defining conditions and HIV-associated mortality in a cohort of HIV-infected patients on ART. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1097/QAI.0000000000001933DOI Listing
December 2018
2 Reads

Mycobacterium avium complex infection in patients with human immunodeficiency virus: A systematic review and meta-analysis.

J Cell Physiol 2018 Dec 12. Epub 2018 Dec 12.

Department of Microbiology, School of Medicine, Iran University of Medical Sciences, Tehran, Iran.

Background: Mycobacterium avium-intracellulare complex (MAC) is one of the leading causes of death among people living with human immunodeficiency virus (HIV). The current study was aimed to determine the frequency of MAC infection in patients infected with HIV.

Methods: Embase, PubMed, and Web of Science were searched for relevant studies. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1002/jcp.27859DOI Listing
December 2018

A retrospective study of factors associated with treatment decision for nontuberculous mycobacterial lung disease in adults without altered systemic immunity.

BMC Infect Dis 2018 Dec 14;18(1):659. Epub 2018 Dec 14.

Département des Maladies infectieuses et tropicales, Hôpital de la Croix-Rousse, Hospices Civils de Lyon, 103, Grande-Rue de la Croix-Rousse, 69317, cedex 04, Lyon, France.

Background: Nontuberculous mycobacteria (NTM) lung diseases are increasingly recognized as chronic opportunistic infections, occurring in individuals with a wide variety of underlying conditions. In the absence of systemic immunodeficiency, decision of NTM lung disease treatment must relies on a careful risk/benefit assessment, given the requirement of long-term administration of multidrug therapies supported by limited evidence. The primary objective was to identify the factors associated with anti-NTM treatment initiation. Read More

View Article

Download full-text PDF

Source
https://bmcinfectdis.biomedcentral.com/articles/10.1186/s128
Publisher Site
http://dx.doi.org/10.1186/s12879-018-3559-xDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6295085PMC
December 2018
2 Reads

Species Typing of Nontuberculous Mycobacteria by Use of Deoxyribozyme Sensors.

Clin Chem 2019 Feb 6;65(2):333-341. Epub 2018 Dec 6.

Division of Immunity and Pathogenesis, Burnett School of Biomedical Sciences, College of Medicine, University of Central Florida, Orlando, FL;

Background: Nontuberculous mycobacteria (NTM) species are a rising threat, especially to patients living with pulmonary comorbidities. Current point-of-care diagnostics fail to adequately identify and differentiate NTM species from (). Definitive culture- and molecular-based testing can take weeks to months and requires sending samples out to specialized diagnostic laboratories. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1373/clinchem.2018.295212DOI Listing
February 2019
2 Reads

Surgery in nontuberculous mycobacteria pulmonary disease.

Breathe (Sheff) 2018 Dec;14(4):288-301

Discipline of Child and Adolescent Health, Sydney Medical School, University of Sydney, Sydney, Australia.

Medical treatment of pulmonary nontuberculous mycobacteria (NTM) disease has highly variable outcomes. Despite the use of multiple antibiotics, sputum clearance is often difficult to achieve, especially in cases with macrolide resistant NTM infection. Immunocompromised patients and those with structural lung disease are at increased risk, although occurrence in immunocompetent patients without structural lung disease is well recognised. Read More

View Article

Download full-text PDF

Source
http://breathe.ersjournals.com/lookup/doi/10.1183/20734735.0
Publisher Site
http://dx.doi.org/10.1183/20734735.027218DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6269180PMC
December 2018
10 Reads

Antibody response against Mycobacterium avium complex in cystic fibrosis patients measured by a novel IgG ELISA test.

J Cyst Fibros 2018 Nov 29. Epub 2018 Nov 29.

Department of Clinical Microbiology, Rigshospitalet, Copenhagen, Denmark; Institute of Immunology and Medical Microbiology, University of Copenhagen, Denmark.

Background: Early signs of Mycobacterium avium complex pulmonary disease can be missed in patients with cystic fibrosis due to subclinical infection or delays in mycobacterial culture. The aim of this study was to determine the diagnostic accuracy of a novel enzyme linked immunosorbent assay for immunoglobulin G against Mycobacterium avium complex, which could help stratify patients according to risk.

Methods: A retrospective cross sectional analysis of serum samples from the Copenhagen Cystic Fibrosis Center was performed. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1016/j.jcf.2018.11.011DOI Listing
November 2018
1 Read

Quantitative assessment of erector spinae muscles in patients with Mycobacterium avium complex lung disease.

Respir Med 2018 Dec 22;145:66-72. Epub 2018 Oct 22.

Center for Infectious Diseases and Infection Control, Keio University School of Medicine, Tokyo, Japan. Electronic address:

Background And Objective: No reports exist regarding skeletal muscle involvement in patients with Mycobacterium avium complex lung disease (MAC-LD). The cross-sectional area of the erector spinae muscles (ESM) reflects physical activity and can be assessed by computed tomography (CT). We investigated the relationship between ESM and physiological parameters and prognosis in MAC-LD patients. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1016/j.rmed.2018.10.023DOI Listing
December 2018
1 Read

Infections with Mycobacterium chimaera and open chest surgery. An unresolved problem.

Med Clin (Barc) 2018 Nov 30. Epub 2018 Nov 30.

Servicio de Medicina Preventiva y Epidemiología, Hospital Universitario Vall d'Hebron, Universitat Autònoma de Barcelona, Barcelona, España.

Mycobacterium chimaera (M. chimaera) is a non-tuberculous mycobacterium of the Mycobacterium avium complex. Between 2013 and April 2018, more than 140 cases of severe infection have been identified, all of them in patients who had undergone cardiothoracic surgery with extracorporeal circulation. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1016/j.medcli.2018.10.013DOI Listing
November 2018
1 Read

Small-Cell Lung Cancer Comorbid with Pulmonary Mycobacterium avium Infection: A Case Report.

Chemotherapy 2018 Nov 22;63(5):257-261. Epub 2018 Nov 22.

Department of Molecular and Internal Medicine, Graduate School of Biomedical and Health Sciences, Hiroshima University, Hiroshima, Japan.

Background: Small-cell lung cancer (SCLC) rarely coexists with pulmonary Mycobacterium avium intracellular complex (MAC) infection. The key drug for SCLC treatment is etoposide, which is metabolized by cytochrome P-450 (CYP) 3A4. Meanwhile, the key drugs for pulmonary MAC infection are clarithromycin (CAM) and rifampicin (RFP), and their metabolism influences CYP3A4. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1159/000494504DOI Listing
November 2018
5 Reads

When occam's razor can fail- active mycobacteria infection and lung cancer: A case of neuroendocrine lung cancer diagnosed in the setting of refractory mycobacterium avium-intracellulare.

Clin Case Rep 2018 Nov 27;6(11):2156-2159. Epub 2018 Sep 27.

Department of Medicine Madigan Army Medical Center Tacoma Washington.

The link between Myobacterium avium-intracellulare and lung cancer remains underemphasized in literature. Our objective is to increase awareness of Myobacterium avium-intracellulare and coexisting lung cancer and to emphasize the need in establishing prevalence and specific testing guidelines in this patient population. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1002/ccr3.1813DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6230639PMC
November 2018

Nontuberculous Mycobacterial Infections in Cystic Fibrosis.

Thorac Surg Clin 2019 Feb;29(1):95-108

Department of Medicine, National Jewish Health, 1400 Jackson Street, Denver, CO 80206, USA; Department of Medicine, University of Colorado Anschutz Medical Campus, 13001 E. 17th Place, Aurora, CO 80045, USA. Electronic address:

Nontuberculous mycobacteria (NTM) are important emerging cystic fibrosis (CF) pathogens, with estimates of prevalence ranging from 6% to 13%. Diagnosis of NTM disease in patients with CF is challenging, as the infection may remain indolent in some, without evidence of clinical consequence, whereas other patients suffer significant morbidity and mortality. Treatment requires prolonged periods of multiple drugs and varies depending on NTM species, resistance pattern, and extent of disease. Read More

View Article

Download full-text PDF

Source
https://linkinghub.elsevier.com/retrieve/pii/S15474127183013
Publisher Site
http://dx.doi.org/10.1016/j.thorsurg.2018.09.008DOI Listing
February 2019
10 Reads

Nontuberculous Mycobacteria: Epidemiology and the Impact on Pulmonary and Cardiac Disease.

Thorac Surg Clin 2019 Feb;29(1):59-64

Department of Medicine, National Jewish Health, 1400 Jackson Street, Denver, CO 80206, USA. Electronic address:

This article reviews the current epidemiology of nontuberculous mycobacterial pulmonary disease and the impact on thoracic disease. The prevalence of nontuberculous pulmonary disease in the United States is much higher than that of Mycobacterium tuberculosis. Estimates support an annual increase in incidence of 8% per year. Read More

View Article

Download full-text PDF

Source
https://linkinghub.elsevier.com/retrieve/pii/S15474127183013
Publisher Site
http://dx.doi.org/10.1016/j.thorsurg.2018.09.006DOI Listing
February 2019
15 Reads

Bronchoscopy as a Useful Examination for Determining Surgical Treatment Indications in Refractory Mycobacterium avium Complex Lung Disease Patients with Bilateral Lesions.

Intern Med 2018 Nov 19. Epub 2018 Nov 19.

Department of Respiratory Medicine, Kanagawa Cardiovascular and Respiratory Center, Japan.

We herein report three cases of refractory Mycobacterium avium complex (MAC) disease successfully treated surgically despite the MAC lesions being present bilaterally. Of note, although two patients did not present with any respiratory symptom, bronchoscopy clearly revealed a major excretory lesion with a large amount of purulent sputum in all patients. Because an excretory lesion was localized, surgical resection was performed, and the mycobacterial sputum smear became negative in all patients. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.2169/internalmedicine.1370-18DOI Listing
November 2018

Cutaneous Mycobacterial Infections.

Clin Microbiol Rev 2018 01 14;32(1). Epub 2018 Nov 14.

Servicio de Dermatología y Departamento de Micología, Hospital General de México, Mexico City, Mexico.

Humans encounter mycobacterial species due to their ubiquity in different environmental niches. In many individuals, pathogenic mycobacterial species may breach our first-line barrier defenses of the innate immune system and modulate the activation of phagocytes to cause disease of the respiratory tract or the skin and soft tissues, sometimes resulting in disseminated infection. Cutaneous mycobacterial infections may cause a wide range of clinical manifestations, which are divided into four main disease categories: (i) cutaneous manifestations of infection, (ii) Buruli ulcer caused by and other related slowly growing mycobacteria, (iii) leprosy caused by and , and (iv) cutaneous infections caused by rapidly growing mycobacteria. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1128/CMR.00069-18DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6302357PMC
January 2018
4 Reads

Severe Progressive Mycobacterium avium Complex Infection Associated With Brentuximab Vedotin Therapy.

J Pediatric Infect Dis Soc 2018 Nov 12. Epub 2018 Nov 12.

Department of Global Pediatric Medicine, St. Jude Children's Research Hospital, Memphis, Tennessee.

View Article

Download full-text PDF

Source
http://fdslive.oup.com/www.oup.com/pdf/production_in_progres
Publisher Site
http://dx.doi.org/10.1093/jpids/piy109DOI Listing
November 2018
9 Reads

Splenic granulomas: a rare manifestation of complex in an immunocompetent host.

BMJ Case Rep 2018 Nov 8;2018. Epub 2018 Nov 8.

Department of Internal Medicine, Post Graduate Institute of Medical Education and Research, Chandigarh, India.

Infections caused by complex (MAC) are commonly seen in immunocompromised individuals. Though disseminated MAC infections with splenic granulomas are seen in some patients, MAC infection clinically manifesting as only splenic granulomas is rare. This presentation is even less common in immunocompetent individuals. Read More

View Article

Download full-text PDF

Source
http://casereports.bmj.com/lookup/doi/10.1136/bcr-2018-22578
Publisher Site
http://dx.doi.org/10.1136/bcr-2018-225788DOI Listing
November 2018
7 Reads

Epidemiology of pulmonary disease due to nontuberculous mycobacteria in Southern China, 2013-2016.

BMC Pulm Med 2018 Nov 9;18(1):168. Epub 2018 Nov 9.

National Clinical Laboratory on Tuberculosis, Beijing Key laboratory on Drug-resistant Tuberculosis Research,, Beijing Chest Hospital, Beijing Tuberculosis and Thoracic Tumor Institute, No. 9, Beiguan Street, Tongzhou District, Beijing, 101149, People's Republic of China.

Background: Pulmonary nontuberculous mycobacteria (NTM) disease is of increasing public health concern in China. Information is limited regarding risk factors associated with this disease in China. The objective of this study was to describe the epidemiology of pulmonary disease due to NTM in Southern China. Read More

View Article

Download full-text PDF

Source
https://bmcpulmmed.biomedcentral.com/articles/10.1186/s12890
Publisher Site
http://dx.doi.org/10.1186/s12890-018-0728-zDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6230232PMC
November 2018
14 Reads
2.490 Impact Factor

Hospital-based antibiotic use in patients with complex.

ERJ Open Res 2018 Oct 2;4(4). Epub 2018 Nov 2.

Epidemiology Unit, Division of Intramural Research, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, MD, USA.

Treatment guidelines exist for pulmonary complex (MAC) infection, although studies suggest poor concordance in clinician practice. Using a national database including hospital encounters of laboratory-confirmed MAC patients, we sought to characterise US treatment practices. We assessed patients in the Premier Healthcare Database from 2009 to 2013 with two or more MAC-positive cultures or one MAC-positive culture and the International Classification of Diseases (9th revision) code for pulmonary nontuberculous mycobacteria (PNTM). Read More

View Article

Download full-text PDF

Source
http://openres.ersjournals.com/lookup/doi/10.1183/23120541.0
Publisher Site
http://dx.doi.org/10.1183/23120541.00109-2018DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6213287PMC
October 2018
6 Reads

[Two cases of hot tub lung disease: Environmental investigations].

Rev Mal Respir 2018 Nov 2. Epub 2018 Nov 2.

Service de pneumologie, CHU Jean-Minjoz, 2, boulevard Fleming, 25030 Besançon cedex, France.

Introduction: Hot tub lung is a hypersensitivity pneumonitis (HP) due to exposure to inhaled non-tuberculous mycobacteria, the most frequent being Mycobacterium avium complex (MAC).

Case Report: A French couple developed typicalHP in the context of a repeated use of hot tubs. The husband had a severe hypoxemic form whereas his wife had a micronodular form with patchy ground glass on the thoracic scan, with less severe functional impairment. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1016/j.rmr.2018.10.006DOI Listing
November 2018
2 Reads

Diagnostic accuracy cohort study and clinical value of the Histoplasma urine antigen (ALPHA Histoplasma EIA) for disseminated histoplasmosis among HIV infected patients: A multicenter study.

PLoS Negl Trop Dis 2018 11 5;12(11):e0006872. Epub 2018 Nov 5.

Department of Infectious Diseases, Instituto Nacional de Ciencias Médicas y Nutrición Salvador Zubirán, Tlalpan, Mexico City, Mexico.

Background: The Histoplasma urine antigen (HUAg) is the preferred method to diagnose progressive disseminated histoplasmosis (PDH) in HIV patients. In 2007, IMMY ALPHA Histoplasma EIA was approved for clinical for on-site use, and therefore useful for regions outside the United States. However, ALPHA-HUAg is considered inferior to the MVista-HUAg which is only available on referral. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1371/journal.pntd.0006872DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6237426PMC
November 2018
2 Reads

Outcomes and risk factors after adjuvant surgical treatments for Mycobacterium avium complex lung disease.

Gen Thorac Cardiovasc Surg 2018 Nov 2. Epub 2018 Nov 2.

Department of Respiratory Medicine, National Hospital Organization Higashinagoya National Hospital, Nagoya, Japan.

Background: Limited information is currently available on the postoperative outcomes of Mycobacterium avium complex lung disease (MAC-LD).

Objective: To show the outcomes of pulmonary resection and identify risk factors after adjuvant surgical treatments for MAC-LD.

Methods: One hundred and eight patients underwent adjuvant lung resection for MAC-LD at two hospitals between January 2008 and July 2016. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1007/s11748-018-1029-4DOI Listing
November 2018