6,982 results match your criteria Mycobacterium Avium-Intracellulare


Nodular distribution pattern on chest computed tomography (CT) in patients diagnosed with nontuberculous mycobacteria (NTM) infections.

Wien Klin Wochenschr 2020 Jul 2. Epub 2020 Jul 2.

Emergency Department of Zagreb County, Matice Hrvatske, Zagreb, Croatia.

Background: This study evaluated the prevalence of spreading pathways in nontuberculous mycobacteria (NTM) pulmonary infections according to nodular distribution patterns seen on chest computed tomography (CT).

Methods: This study included 63 patients diagnosed with NTM lung infections who underwent CT at our institution. A retrospective analysis of CT images focused on the presence and distribution of nodules, presence of intrathoracic lymphadenopathy and the predominant side of infection in the lungs. Read More

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http://dx.doi.org/10.1007/s00508-020-01701-1DOI Listing

The Use of Amikacin Liposome Inhalation Suspension (Arikayce) in the Treatment of Refractory Nontuberculous Mycobacterial Lung Disease in Adults.

Drug Des Devel Ther 2020 10;14:2287-2294. Epub 2020 Jun 10.

Division of Pulmonary Disease and Critical Care Medicine, Department of Medicine, Virginia Commonwealth University, Richmond, VA, USA.

Nontuberculous mycobacteria (NTM) can cause and perpetuate chronic inflammation and lung infection. Despite having the diagnostic criteria, as defined by the American Thoracic Society (ATS) and Infectious Diseases Society of America (IDSA), clinicians find it challenging to diagnose and treat NTM-induced lung disease. Inhaled antibiotics are suitable for patients with lung infection caused by and other organisms, but until recently, their utility in NTM-induced infection was not established. Read More

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http://dx.doi.org/10.2147/DDDT.S146111DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7293904PMC

Serum Krebs von den Lungen-6 level in the disease progression and treatment of Mycobacterium avium complex lung disease.

Respirology 2020 Jun 29. Epub 2020 Jun 29.

Department of Infectious Diseases, Keio University School of Medicine, Tokyo, Japan.

Background And Objective: The lack of useful biomarkers reflecting the disease state limits the management of Mycobacterium avium complex lung disease (MAC-LD). We clarified the associations between serum KL-6 level, disease progression and treatment response.

Methods: Resected lung tissues from MAC-LD patients were immunostained for KL-6. Read More

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http://dx.doi.org/10.1111/resp.13886DOI Listing

Cytomorphology of Mycobacterium avium intracellulare-associated ascites.

Diagn Cytopathol 2020 Jun 27. Epub 2020 Jun 27.

Department of Pathology, University of Pittsburgh Medical Center, Pittsburgh, Pennsylvania, USA.

Ascites due to Mycobacterium avium intracellulare (MAI) infection is extremely rare and associated with a poor outcome. The cytomorphology of this condition has not been previously reported. We present a unique case of a 45-year-old woman with iatrogenic immunodeficiency who developed MAI-associated chylous ascites. Read More

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http://dx.doi.org/10.1002/dc.24532DOI Listing

The rough colony morphotype of exhibits high virulence in human macrophages and mice.

J Med Microbiol 2020 Jun 26. Epub 2020 Jun 26.

Department of Infectious Diseases, Keio University School of Medicine, Shinjuku-ku, Tokyo, Japan.

The incidence of complex (MAC) pulmonary disease (MAC PD), a refractory chronic respiratory tract infection, is increasing worldwide. MAC has three predominant colony morphotypes: smooth opaque (SmO), smooth transparent (SmT) and rough (Rg). To determine whether colony morphotypes can predict the prognosis of MAC PD, we evaluated the virulence of SmO, SmT and Rg in mice and in human macrophages. Read More

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http://dx.doi.org/10.1099/jmm.0.001224DOI Listing

Characteristics of Nontuberculous Mycobacterial Infections at a Midwestern Tertiary Hospital: A Retrospective Study of 365 Patients.

Open Forum Infect Dis 2020 Jun 25;7(6):ofaa173. Epub 2020 May 25.

Department of Dermatology, Medical College of Wisconsin, Milwaukee, Wisconsin, USA.

Background: The prevalence of infections due to nontuberculous mycobacteria (NTM) is increasing worldwide, yet little is known about the epidemiology and pathophysiology of these ubiquitous environmental organisms. Pulmonary disease due to complex is most prevalent, but many other NTM species can cause disease in virtually any organ system. As NTM becomes an increasingly common cause of morbidity and mortality, more information is needed about the epidemiology of NTM disease. Read More

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http://dx.doi.org/10.1093/ofid/ofaa173DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7305701PMC

Vaccine Vector Elicits CD4+ Th17 and CD8+ Tc17 T Cells With Therapeutic Potential to Infections With .

Front Immunol 2020 9;11:1116. Epub 2020 Jun 9.

Center of Molecular Inflammation Research and Department of Clinical and Molecular Medicine, Norwegian University of Science and Technology (NTNU), Trondheim, Norway.

(Mav) complex is increasingly reported to cause non-tuberculous infections in individuals with a compromised immune system. Treatment is complicated and no vaccines are available. Previous studies have shown some potential of using genetically modified (Msm) as a vaccine vector to tuberculosis since it is non-pathogenic and thus would be tolerated by immunocompromised individuals. Read More

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http://dx.doi.org/10.3389/fimmu.2020.01116DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7296097PMC

Of tuberculosis and non-tuberculous mycobacterial infections - a comparative analysis of epidemiology, diagnosis and treatment.

J Biomed Sci 2020 Jun 17;27(1):74. Epub 2020 Jun 17.

Public Health Research Institute, New Jersey Medical School, Rutgers, The State University of New Jersey, Newark, NJ, United States.

Pulmonary diseases due to mycobacteria cause significant morbidity and mortality to human health. In addition to tuberculosis (TB), caused by Mycobacterium tuberculosis (Mtb), recent epidemiological studies have shown the emergence of non-tuberculous mycobacteria (NTM) species in causing lung diseases in humans. Although more than 170 NTM species are present in various environmental niches, only a handful, primarily Mycobacterium avium complex and M. Read More

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http://dx.doi.org/10.1186/s12929-020-00667-6DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7297667PMC

Age- and sex-related characteristics of the increasing trend of nontuberculous mycobacteria pulmonary disease in a tertiary hospital in South Korea from 2006 to 2016.

Korean J Intern Med 2020 Jun 19. Epub 2020 Jun 19.

Division of Pulmonology, Department of Internal Medicine, Severance Hospital, Yonsei University College of Medicine, Seoul, Korea.

Background/aims: The incidence rate of nontuberculous mycobacterial pulmonary disease (NTM-PD) is increasing worldwide. However, data regarding the age- and sex-specific epidemiology of NTM-PD are limited. This study aimed to investigate the long-term epidemiologic trends of NTM-PD within the recent 11- year period in a tertiary referral hospital in Korea. Read More

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http://dx.doi.org/10.3904/kjim.2019.395DOI Listing

The impact of adjuvant surgical treatment of nontuberculous mycobacterial pulmonary disease on prognosis and outcome.

Respir Res 2020 Jun 16;21(1):153. Epub 2020 Jun 16.

Department of Respiratory Medicine, National Hospital Organization Osaka Toneyama Medical Center, 5-1-1 Toneyama Toyonaka, Osaka, Japan.

Background: Lung resection in patients with nontuberculous mycobacterial pulmonary disease (NTM-PD) has been reported to be associated with favorable outcomes. However, little is known regarding the risk and prognostic factors for refractory and recurrent cases. We aimed to evaluate the overall impact and benefit of adjuvant lung surgery by comparing NTM-PD patients who underwent adjuvant lung resection with those treated exclusively with antibiotics. Read More

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http://dx.doi.org/10.1186/s12931-020-01420-1DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7298848PMC

Efflux Pump Inhibitors Against Nontuberculous Mycobacteria.

Authors:
Laura Rindi

Int J Mol Sci 2020 Jun 12;21(12). Epub 2020 Jun 12.

Dipartimento di Ricerca Traslazionale e delle Nuove Tecnologie in Medicina e Chirurgia, Università di Pisa, I-56127 Pisa, Italy.

Over the last years, nontuberculous mycobacteria (NTM) have emerged as important human pathogens. Infections caused by NTM are often difficult to treat due to an intrinsic multidrug resistance for the presence of a lipid-rich outer membrane, thus encouraging an urgent need for the development of new drugs for the treatment of mycobacterial infections. Efflux pumps (EPs) are important elements that are involved in drug resistance by preventing intracellular accumulation of antibiotics. Read More

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http://dx.doi.org/10.3390/ijms21124191DOI Listing

Use of MALDI-TOF MS (Bruker Daltonics) for identification of Mycobacterium species isolated directly from liquid medium.

Enferm Infecc Microbiol Clin 2020 Jun 11. Epub 2020 Jun 11.

Servicio de Microbiología, Hospital Universitario Miguel Servet. IIS Aragón, Zaragoza, Spain; Grupo de estudio de las Infecciones por Micobacterias (GEIM), Sociedad Española de Microbiología y Enfermedades Infecciosas, Spain.

Objectives: The aim of this study was to describe the evaluation of the use of MALDI-TOF MS for the identification of non-tuberculous mycobacteria (NTM) and Mycobacterium tuberculosis directly from liquid MGIT cultures from January 2017 to December 2017.

Material/methods: A total of 155 isolates (mainly respiratory) were analyzed by MALDI-TOF MS (Bruker Daltonics) directly from MGIT liquid medium with a previous extraction procedure.

Results: MALDI-TOF MS generated acceptable scores for 152 isolates (98. Read More

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http://dx.doi.org/10.1016/j.eimc.2020.05.011DOI Listing

Different clinical features of patients with pulmonary disease caused by various Mycobacterium avium-intracellulare complex subspecies and antimicrobial susceptibility.

Int J Infect Dis 2020 Jun 10. Epub 2020 Jun 10.

Department of Internal Medicine, National Taiwan University Hospital, National Taiwan University College of Medicine, Taipei, Taiwan. Electronic address:

Objectives: Characteristics of the Mycobacterium avium-intracellulare complex pulmonary disease (MAC-PD) caused by distinct subspecies remain uncertain.

Methods: This study was conducted from 2013 to 2015 in three hospitals in Taiwan.

Results: Among the 144 patients with MAC-PD, 57(39. Read More

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http://dx.doi.org/10.1016/j.ijid.2020.06.019DOI Listing

Prevalence of nontuberculous mycobacteria in a tertiary hospital in Beijing, China, January 2013 to December 2018.

BMC Microbiol 2020 Jun 12;20(1):158. Epub 2020 Jun 12.

Department of Clinical Laboratory, Peking Union Medical College Hospital, Peking Union Medical College, Chinese Academy of Medical Sciences, Beijing, 100730, China.

Background: To investigate the species distribution of non-tuberculous mycobacteria (NTM) among tuberculosis (TB) specimens collected from January 2013 to December 2018 at Peking Union Medical Hospital (Beijing), China. NTM species identification was carried out by DNA microarray chip.

Results: Mycobacterial species were detected in 1514 specimens from 1508 patients, among which NTM accounted for 37. Read More

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http://dx.doi.org/10.1186/s12866-020-01840-5DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7291475PMC

Polymicrobial Intracerebral Abscess Growing Mycobacterium avium complex and Achromobacter xylosoxidans: Case Report and Literature Review.

World Neurosurg 2020 Jun 7. Epub 2020 Jun 7.

Department of Neurologic Surgery, Mayo Clinic, Rochester MN; Department of Otolaryngology-Head and Neck Surgery, Mayo Clinic, Rochester MN. Electronic address:

Background: Mycobacterium avium complex (MAC) and Achromobacter xylosoxidans (AX) are uncommon sources of neurosurgical infections, particularly in immunocompetent hosts. We report the first published case of intracranial AX abscess and polymicrobial AX-MAC abscess, as well as the fourth MAC abscess in a non-immunocompromised patient.

Methods: This case report was conducted via retrospective chart review. Read More

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http://dx.doi.org/10.1016/j.wneu.2020.05.283DOI Listing

Antibiotic treatment for nontuberculous mycobacteria lung infection in people with cystic fibrosis.

Cochrane Database Syst Rev 2020 Jun 10;6:CD010004. Epub 2020 Jun 10.

Department of Pediatrics, The Hospital for Sick Children, Toronto, Canada.

Background: Nontuberculous mycobacteria are mycobacteria, other than those in the Mycobacterium tuberculosis complex, and are commonly found in the environment. Nontuberculous mycobacteria species (most commonly Mycobacterium avium complex and Mycobacterium abscessus) are isolated from the respiratory tract of approximately 5% to 40% of individuals with cystic fibrosis; they can cause lung disease in people with cystic fibrosis leading to more a rapid decline in lung function and even death in certain circumstances. Although there are guidelines for the antimicrobial treatment of nontuberculous mycobacteria lung disease, these recommendations are not specific for people with cystic fibrosis and it is not clear which antibiotic regimen may be the most effective in the treatment of these individuals. Read More

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http://dx.doi.org/10.1002/14651858.CD010004.pub5DOI Listing

Posttreatment lymphopenia is associated with an increased risk of redeveloping nontuberculous lung disease in patients with Mycobacterium avium complex lung disease.

Clin Infect Dis 2020 Jun 7. Epub 2020 Jun 7.

Respiratory Disease Center,Fukujuji Hospital, Japan Anti-Tuberculosis Association, Tokyo, Japan.

Objectives: Lymphopenia has been reported as a risk factor for poor prognosis in various infectious diseases, including Mycobacterium avium complex lung disease (MAC-LD), and recurrence in several infectious diseases. However, the association between lymphopenia and the risk of redeveloping nontuberculous lung disease (NTM-LD) after completed treatment for MAC-LD is unknown.

Methods: We performed a retrospective cohort study with 147 patients with MAC-LD who successfully completed guideline-based therapy. Read More

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http://dx.doi.org/10.1093/cid/ciaa729DOI Listing

Acute Hypersensitivity Pneumonitis Associated With a High Ki-67 Proliferative Index.

Cureus 2020 Apr 30;12(4):e7905. Epub 2020 Apr 30.

Pulmonary and Critical Care Medicine, Advocate Lutheran General Hospital, Park Ridge, USA.

Hypersensitivity pneumonitis (HSP) is an interstitial lung disease caused by exposure to a large range of environmental antigens. Inhaling aerosolized particles leads to a heightened immune response. HSP comes in acute, subacute, or chronic forms, all with their own potential clinical and radiographic findings. Read More

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http://dx.doi.org/10.7759/cureus.7905DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7263412PMC

Bone Marrow Culture Yield for the Diagnosis of Opportunistic Diseases in Patients with AIDS and Disseminated Kaposi Sarcoma.

Curr HIV Res 2020 Jun 3. Epub 2020 Jun 3.

Infectious Diseases Department, Instituto Nacional de Cancerología, Mexico City. Mexico.

Background: Disseminated Kaposi sarcoma (DKS) is present in patients with advanced HIV infection in whom co-infection with other opportunistic pathogens can occur. Bone marrow (BM) aspirate and biopsy comprises a robust diagnostic tool in patients with fever, cytopenias, and abnormal liver tests. However, the yield in patients with DKS has not been determined. Read More

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http://dx.doi.org/10.2174/1570162X18666200603145640DOI Listing

A case of pulmonary infection in a healthy Japanese man.

Respir Med Case Rep 2020 16;30:101093. Epub 2020 May 16.

Division of Respirology, Neurology and Rheumatology, Department of Medicine, Kurume University School of Medicine, Fukuoka, 830-0011, Japan.

A 72-year-old man, healthy, smoker, with long-standing cough, was referred to our hospital and his chest X-ray (CXR) revealed a cavity lesion in the right upper lobe. Direct sputum smears, but not culture in solid medium, were positive for acid-fast bacilli (AFB) without tuberculosis DNA. The preliminary diagnosis was of a non-tuberculosis infection that progressed slowly, and the CXR showed the condition to worsen daily. Read More

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http://dx.doi.org/10.1016/j.rmcr.2020.101093DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7256317PMC

[Pathological characteristics and molecular diagnosis of non-tuberculosis lung disease].

Zhonghua Bing Li Xue Za Zhi 2020 Jun;49(6):562-567

Department of Pathology, Beijing Chest Hospital, Capital Medical University; Beijing Tuberculosis and Thoracic Tumor Research Institute, Beijing 101149, China.

To investigate the clinicopathological features of non-tuberculosis mycobacterial lung disease and the role of molecular pathology in diagnosis. Forty-five formalin-fixed, paraffin embedded (FFPE) specimens were collected from the Department of Pathology, Beijing Chest Hospital from February 2016 to August 2019. The clinical, imaging and histopathologic features, bacteriologic data and morphologic characteristics of acid fast bacilli (AFB) were analyzed retrospectively. Read More

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http://dx.doi.org/10.3760/cma.j.cn112151-20191028-00669DOI Listing

Nontuberculous mycobacterial lung disease epidemiology in Taiwan: A systematic review.

J Formos Med Assoc 2020 Jun 30;119 Suppl 1:S4-S12. Epub 2020 May 30.

Respiratory and Critical Care Center, Changhua Hospital, Ministry of Health & Welfare, Changhua, Taiwan. Electronic address:

Nontuberculous mycobacteria (NTM) are critical emerging global infectious pathogens. Though NTM can be mere colonizers when isolated from human specimens, NTM are also responsible for diverse human infections. NTM-lung disease (NTM-LD) is the most common human disease entity. Read More

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http://dx.doi.org/10.1016/j.jfma.2020.05.019DOI Listing
June 2020
1.695 Impact Factor

Assessing efficacy of N-Acetyl-l-Cysteine-Sodium Hydroxide on bacterial viability and enhanced recovery of Mycobacterium avium subsp. paratuberculosis from bovine colostrum.

J Microbiol Methods 2020 May 29;175:105968. Epub 2020 May 29.

Institute of Veterinary Food Science, Justus-Liebig-University Gießen, Frankfurter Street 92, D-35392 Gießen, Germany.

The standard procedure for the improved cultural recovery of viable Mycobacterium spp. from diverse samples mainly depends on reducing the viability of background microbiota using different chemical compounds. This study was designed to i) evaluate the efficacy and comparison between N-Acetyl-l-Cysteine-Sodium hydroxide (NALC-2% NaOH) and hexadecylpyridinium chloride (0. Read More

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http://dx.doi.org/10.1016/j.mimet.2020.105968DOI Listing

Serum immunoglobulin a antibodies to glycopeptidolipid core antigen for complex lung disease.

Int J Mycobacteriol 2020 Jan-Mar;9(1):76-82

Department of Internal Medicine, National Hospital Organization, Kinki-Chuo Chest Medical Center, Sakai City, Osaka, Japan.

Background: Mycobacteroides abscessus complex (MABC) exhibits smooth morphotypes, expressing glycopeptidolipid (GPL), and rough morphotypes, expressing diminished GPL, on the MABC cell wall. Few reports have focused on the relationship between anti-GPL-core immunoglobulin A (IgA) antibody and colony morphology in MABC lung disease.

Methods: This study aimed to test GPL core antigen in patients with MABC lung disease to investigate the relationship between coinfection/contamination in other nontuberculous mycobacteria species and colony morphology variant in MABC isolates. Read More

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http://dx.doi.org/10.4103/ijmy.ijmy_14_20DOI Listing

Residual Destructive Lesions and Surgical Outcome in Mycobacterium avium complex Pulmonary Disease.

Ann Thorac Surg 2020 May 27. Epub 2020 May 27.

Section of Chest Surgery.

Background: Successful surgical treatment of patients with Mycobacterium avium complex pulmonary disease is thought to require complete removal of parenchymal destructive lesions. This study aimed to evaluate the short- and long-term outcomes and the predictors of microbiological recurrence after surgery for Mycobacterium avium complex pulmonary disease.

Methods: We conducted a retrospective review of 184 patients undergoing unilateral lung resection for Mycobacterium avium complex pulmonary disease at a single center in Japan between January 2008 and December 2017. Read More

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http://dx.doi.org/10.1016/j.athoracsur.2020.04.034DOI Listing

Adrenal paracoccidioidomycosis

Biomedica 2020 05 1;40(Supl. 1):20-22. Epub 2020 May 1.

Departamento de Patología, Universidad de Antioquia, Medellín, Colombia.

Primary adrenal insufficiency is a defect in glucocorticoid, mineralocorticoid and sexual androgens production. Patients with this disorder have low cortisol levels and aldosterone deficiency with concomitant hyponatremia and hyperkalemia. The most common etiology of this disease is the production of antibodies against the enzyme 21 hydroxylase. Read More

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http://dx.doi.org/10.7705/biomedica.4844DOI Listing

Treatment for Mycobacterium avium complex lung disease.

J Formos Med Assoc 2020 Jun 20;119 Suppl 1:S67-S75. Epub 2020 May 20.

Department of Chest Medicine, Taipei Veterans General Hospital, Taipei, Taiwan; School of Medicine, National Yang-Ming University, Taipei, Taiwan. Electronic address:

Mycobacterium avium complex (MAC) is the major pathologic nontuberculous mycobacteria causing lung disease (LD) in humans worldwide. Although the burden of MAC-LD has increased over the past two decades, treatment remains difficult because of intolerance of long-term antibiotics, lack of adherence to guidelines, and disease recurrence. The current guidelines recommend antibiotic initiation for patients with MAC-LD and severe disease and in those with disease progression. Read More

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http://dx.doi.org/10.1016/j.jfma.2020.05.006DOI Listing

Macrolide resistant Mycobacterium avium complex pulmonary disease following clarithromycin and ethambutol combination therapy.

Respir Med 2020 Aug 15;169:106025. Epub 2020 May 15.

Department of Respiratory Medicine, National Hospital Organization, Tenryu Hospital, Hamamatsu, Japan.

Rationale: Whether two-drug therapy (clarithromycin and ethambutol) for Mycobacterium avium complex (MAC) pulmonary disease contributes to the development of macrolide-resistant MAC is unclear.

Objective: To compare the incidence of macrolide-resistant MAC between patients treated with two-drug therapy (clarithromycin and ethambutol) and the standard three-drug therapy (clarithromycin, ethambutol, and rifampicin) for MAC pulmonary disease.

Methods: We retrospectively reviewed 147 patients with treatment-naive MAC pulmonary disease who had received two-drug therapy (n = 47) or three-drug therapy (n = 100) between 1997 and 2016 at National Hospital Organization, Tenryu Hospital, Hamamatsu, Japan. Read More

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http://dx.doi.org/10.1016/j.rmed.2020.106025DOI Listing

Nontuberculous mycobacterial infection in a tertiary care center in Mexico, 2001-2017.

Braz J Infect Dis 2020 May 16. Epub 2020 May 16.

Instituto Nacional de Ciencias Médicas y Nutrición Salvador Zubirán, Department of Infectious Diseases, Laboratory of Clinical Microbiology, Mexico City, Mexico. Electronic address:

Introduction: Nontuberculous mycobacteria (NTM) comprise several pathogens with a complex profile of virulence, diverse epidemiological and clinical patterns as well as host specificity. Recently, an increase in the number of NTM infections has been observed; therefore, the objective of this study was to evaluate the clinical characteristics and outcomes of these infections.

Methods: We included patients with NTM infections between 2001-2017 and obtained risk factors, clinical features and outcomes; finally, we compared this data between slowly growing (SGM) and rapidly growing mycobacteria (RGM). Read More

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http://dx.doi.org/10.1016/j.bjid.2020.04.012DOI Listing

Clinical outcomes in Mycobacterium xenopi versus Mycobacterium avium complex pulmonary disease: A retrospective matched cohort study.

Respir Med 2020 Jun 15;167:105967. Epub 2020 Apr 15.

Division of Respirology, Department of Medicine, University of Toronto, Toronto, Canada; Division of Respirology, Department of Medicine, Toronto Western Hospital, Toronto, Canada.

Mycobacterium xenopi is associated with the highest mortality among pulmonary nontuberculous mycobacterial (NTM) infections, but whether this is due to the infection or other factors is unclear. There is little information regarding outcomes among patients infected with M. xenopi versus other NTM species. Read More

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http://dx.doi.org/10.1016/j.rmed.2020.105967DOI Listing

Genome Subtraction and Comparison for the Identification of Novel Drug Targets against subsp. .

Pathogens 2020 May 12;9(5). Epub 2020 May 12.

Natural and Medical Sciences Research Center, University of Nizwa, P.O. Box 33, Birkat Al Mauz, Nizwa 616, Oman.

complex (MAC) is a major cause of non-tuberculous pulmonary and disseminated diseases worldwide, inducing bronchiectasis, and affects HIV and immunocompromised patients. In MAC, subsp. is a pathogen that infects humans and mammals, and that is why it is a focus of this study. Read More

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http://dx.doi.org/10.3390/pathogens9050368DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7281720PMC

Nontuberculous mycobacteria in patients with suspected tuberculosis and the genetic diversity of Mycobacterium avium in the extreme south of Brazil.

J Bras Pneumol 2020 11;46(2):e20190184. Epub 2020 May 11.

Núcleo de Pesquisa em Microbiologia Médica, Faculdade de Medicina, Universidade Federal do Rio Grande, Rio Grande, RS, Brazil.

Objective: Nontuberculous mycobacteria (NTM) are a heterogeneous group of bacteria that are widely distributed in nature and associated with opportunistic infections in humans. The aims of this study were to identify NTM in patients with suspected tuberculosis who presented positive cultures and to evaluate the genetic diversity of strains identified as Mycobacterium avium.

Methods: We studied pulmonary and extrapulmonary samples obtained from 1,248 patients. Read More

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http://dx.doi.org/10.36416/1806-3756/e20190184DOI Listing

Rifabutin corneal deposits localized to the deep stroma using anterior segment optical coherence tomography.

Am J Ophthalmol Case Rep 2020 Jun 11;18:100701. Epub 2020 Apr 11.

Department of Ophthalmology, University of California San Francisco, USA.

Purpose: To demonstrate that rifabutin-related corneal deposits are localized to the deep stroma using anterior segment optical coherence tomography (OCT) and confocal microscopy.

Observations: A 55-year-old male with a history of human immunodeficiency virus (HIV) and disseminated mycobacterium avium complex on rifabutin treatment for 3 years presented with bilateral corneal deposits. Confocal microscopy and anterior segment OCT confirm that rifabutin-related corneal deposits are located in the deep stroma, rather than in the endothelium. Read More

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http://dx.doi.org/10.1016/j.ajoc.2020.100701DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7200216PMC

Recent increase in non-tuberculous mycobacterial infection in patients with connective tissue diseases in Japan.

J Infect Chemother 2020 May 3. Epub 2020 May 3.

Department of Internal Medicine, Teikyo University, 2-11-1, Kaga, Itabashi-ku, Tokyo, Japan; National Hospital Organization Higashisaitama Hospital, Hasuda, 4147, Kurohama, Saitama, Japan.

Background: Non-tuberculous mycobacterial (NTM) infection is currently a growing health concern due to the increasing incidence and the need for prolonged therapy. In patients with connective tissue diseases, use of immunosuppressants may lead to an increased risk of NTM infection. However, few studies have examined the recent incidence of NTM infection among connective tissue diseases patients. Read More

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http://dx.doi.org/10.1016/j.jiac.2020.04.013DOI Listing

Characteristics of Circulating CD4 T Cell Subsets in Patients with Complex Pulmonary Disease.

J Clin Med 2020 May 3;9(5). Epub 2020 May 3.

Division of Pulmonary and Critical Care Medicine, Department of Medicine, Samsung Medical Center, Sungkyunkwan University School of Medicine, Seoul 06351, Korea.

Although prevalence of complex pulmonary disease (MAC-PD) is increasing, limited data are available regarding vulnerability to complex (MAC) infections. To understand the pathobiology of interaction between MAC and host-immunity, it is important to understand the characteristics for circulating T cells in terms of the immunological phenotype and functional correlates in MAC-PD. We aimed to characterize immunophenotype, cytokine profile, and immune inhibitory receptors of circulating CD4 T cells in MAC-PD patients. Read More

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http://dx.doi.org/10.3390/jcm9051331DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7290757PMC

Impact of prognostic nutritional index on outcomes in patients with Mycobacterium avium complex pulmonary disease.

PLoS One 2020 6;15(5):e0232714. Epub 2020 May 6.

Division of Pulmonology, Department of Internal Medicine, Severance Hospital, Yonsei University College of Medicine, Seoul, Republic of Korea.

Onodera's prognostic nutritional index (PNI) is useful in predicting prognosis of various diseases. But the usefulness of PNI in non-surgical patients has not been sufficiently proven yet. In patients with mycobacterium avium complex pulmonary disease (MAC-PD), malnutrition is an important factor that affects the quality of life and morbidity. Read More

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http://journals.plos.org/plosone/article?id=10.1371/journal.pone.0232714PLOS
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7202629PMC

Long-Term Treatment Outcome of Progressive Complex Pulmonary Disease.

J Clin Med 2020 May 2;9(5). Epub 2020 May 2.

Department of Respiratory Medicine, National Hospital Organization Osaka Toneyama Medical Centre, 5-1-1 Toneyama, Toyonaka, Osaka 560-8552, Japan.

Background: Multidrug therapy is essential for preventing respiratory failure in patients with highly progressive complex pulmonary disease (MAC-PD). However, the prognosis and long-term outcome following combination therapy is poorly understood.

Methods: We retrospectively evaluated the clinical characteristics and long-term outcomes in patients with chemo-naïve progressive MAC-PD, hospitalized for first-line multidrug therapy. Read More

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http://dx.doi.org/10.3390/jcm9051315DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7291046PMC

Comparison of multiplex and ordinary PCR for diagnosis of paratuberculosis and tuberculosis in blood samples (buffy coat) of cattle and buffaloes.

Iran J Vet Res 2020 ;21(1):52-56

Directorate of Livestock Farm, College of Veterinary Science, Guru Angad Dev Veterinary and Animal Sciences University, Ludhiana-141004, Punjab, India.

Background: Paratuberculosis and tuberculosis (TB) caused by (MAP) and complex (MTC), respectively are economically important, chronic debilitating diseases affecting the dairy herds and are also potential zoonotic threats.

Aims: Differential diagnosis of paratuberculosis and TB in blood samples of cattle and buffaloes.

Methods: In this study, an in-house developed multiplex polymerase chain reaction (PCR) targeting MAP, and was used in blood samples (buffy coat) parallel with IS PCR and B PCR for diagnosis of paratuberculosis and TB, respectively; in a total of 202 cattle and buffaloes. Read More

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http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7183380PMC
January 2020

Impact of different subspecies on disease progression in initially untreated patients with Mycobacterium avium complex lung disease.

Clin Microbiol Infect 2020 Apr 28. Epub 2020 Apr 28.

Department of Chest Medicine, Taipei Veterans General Hospital, Taipei, Taiwan; School of Medicine, National Yang-Ming University, Taipei, Taiwan. Electronic address:

Objective: Disease progression is a strong indicator of treatment for Mycobacterium avium complex lung disease (MAC-LD). The impact of MAC subspecies on the risk of disease progression remains uncertain in MAC-LD patients.

Methods: In this cohort study, we included MAC-LD patients from 2013 to 2018 and classified them into M. Read More

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http://dx.doi.org/10.1016/j.cmi.2020.04.020DOI Listing

2019 Year in Review: Aerosol Therapy.

Authors:
Ariel Berlinski

Respir Care 2020 May;65(5):705-712

Department of Pediatrics, College of Medicine, University of Arkansas for Medical Sciences, Little Rock, Arkansas.

Relevant publications related to medicinal and toxic aerosols are discussed in this review. Treatment of COPD includes a combination of long-acting bronchodilators and long-acting muscarinic antagonists. A combination of aclidinium bromide and formoterol fumarate was approved in the United States. Read More

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http://dx.doi.org/10.4187/respcare.07738DOI Listing

Paratuberculosis at European scale: an overview from 2010 to 2017.

Vet Ital 2020 Apr 24;56(1). Epub 2020 Apr 24.

University of TurinDepartment of Veterinary Sciences.

Mycobacterium avium subsp. paratuberculosis (MAP) is the etiological agent of paratuberculosis (PTB), a disease affecting domestic and wild ruminants. MAP may also play a zoonotic role in Crohn's disease. Read More

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http://dx.doi.org/10.12834/VetIt.1829.9692.3DOI Listing

Assessment of current diagnostic algorithm for detection of mixed infection with Mycobacterium tuberculosis and nontuberculous mycobacteria.

J Infect Public Health 2020 Apr 22. Epub 2020 Apr 22.

National Clinical Laboratory on Tuberculosis, Beijing Key Laboratory on Drug-resistant Tuberculosis Research, Beijing Chest Hospital, Capital Medical University, Beijing Tuberculosis and Thoracic Tumor Institute, Beijing, China. Electronic address:

Background: The increasing pulmonary diseases are reported to be affected by mixed infection of Mycobacterium tuberculosis (MTB) and nontuberculous mycobacteria (NTM). In this study, our objective was to assess the efficiency of mycobacterial culture plus DNA sequencing to detect the mixed infections with MTB and various NTM organisms. We also aimed to investigate how efficiently GeneXpert detected MTB in mixed infections with NTM in in vitro models. Read More

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http://dx.doi.org/10.1016/j.jiph.2020.03.017DOI Listing

Bilateral Pneumonia in a Patient with Chronic Bronchiectasis Caused by Achromobacter xylosoxidans Subspecies denitrificans.

Cureus 2020 Mar 23;12(3):e7381. Epub 2020 Mar 23.

Internal Medicine, Medical Center of Trinity, Trinity, USA.

is a gram-negative bacillus that has a multitude of inherent and acquired antimicrobial resistance. It is a rare, isolated pathogen in patients without cystic fibrosis (CF). We report the case of a 76-year-old Caucasian male with a history of chronic obstructive pulmonary disease (COPD), previous (MAI) infection, and chronic bronchiectasis who did not respond to three courses of outpatient antibiotics for a chronic cough. Read More

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http://dx.doi.org/10.7759/cureus.7381DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7176333PMC

Whole genome sequencing of Nontuberculous Mycobacterium (NTM) isolates from sputum specimens of co-habiting patients with NTM pulmonary disease and NTM isolates from their environment.

BMC Genomics 2020 Apr 23;21(1):322. Epub 2020 Apr 23.

Division of Pulmonary and Critical Care Medicine, Department of Internal Medicine, Seoul National University College of Medicine, Seoul, Republic of Korea.

Background: Nontuberculous mycobacterium (NTM) species are ubiquitous microorganisms. NTM pulmonary disease (NTM-PD) is thought to be caused not by human-to-human transmission but by independent environmental acquisition. However, recent studies using next-generation sequencing (NGS) have reported trans-continental spread of Mycobacterium abscessus among patients with cystic fibrosis. Read More

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http://dx.doi.org/10.1186/s12864-020-6738-2DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7181514PMC

Clinical Management of Respiratory Adverse Events Associated With Amikacin Liposome Inhalation Suspension: Results From a Patient Survey.

Open Forum Infect Dis 2020 Apr 2;7(4):ofaa079. Epub 2020 Mar 2.

Section of Pulmonary/Critical Care Medicine & Allergy/Immunology, Louisiana State University Health Sciences Center, New Orleans, Louisiana, USA.

Patients with complex lung disease treated with amikacin liposome inhalation suspension (ALIS) at 2 clinics in the United States were surveyed to assess the frequency and management of ALIS-associated respiratory adverse events. Most respondents experienced these events, but management through physician-guided measures (eg, bronchodilator use, oral rinses, and/or temporary dosing adjustments) resulted in symptomatic improvement. Read More

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http://dx.doi.org/10.1093/ofid/ofaa079DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7162617PMC

Impact of Aspergillus precipitating antibody test results on clinical outcomes of patients with Mycobacterium avium complex lung disease.

Respir Med 2020 May 4;166:105955. Epub 2020 Apr 4.

Respiratory Disease Center, Fukujuji Hospital, Japan Anti-Tuberculosis Association, Tokyo, Japan; Division of Clinical Research, Fukujuji Hospital, Japan Anti-Tuberculosis Association, Tokyo, Japan. Electronic address:

Background And Objective: Chronic pulmonary aspergillosis (CPA) is associated with mortality in patients with Mycobacterium avium complex lung disease (MAC-LD). However, the clinical significance of the positivity of Aspergillus precipitating antibody (APAb), a serodiagnostic test for pulmonary aspergillosis (PA), at the time of MAC-LD diagnosis is unknown. The objective of this study was to investigate the effects of APAb test results on the clinical outcomes of patients with MAC-LD. Read More

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http://dx.doi.org/10.1016/j.rmed.2020.105955DOI Listing

Thioridazine Is an Efflux Pump Inhibitor in Mycobacterium avium Complex but of Limited Clinical Relevance.

Antimicrob Agents Chemother 2020 Jun 23;64(7). Epub 2020 Jun 23.

Radboud Center for Infectious Diseases, Department of Medical Microbiology, Radboud University Medical Center, Nijmegen, The Netherlands

Treatment of complex pulmonary disease (MAC-PD) is challenging partly due to high efflux pump expression. Thioridazine might block these efflux pumps. We explore the efficacy of thioridazine against isolates using MICs, time-kill combination assays, macrophage infection assays, and efflux assays. Read More

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http://dx.doi.org/10.1128/AAC.00181-20DOI Listing
June 2020
4.476 Impact Factor

subsp MAP1889c Protein Induces Maturation of Dendritic Cells and Drives Th2-biased Immune Responses.

Cells 2020 Apr 11;9(4). Epub 2020 Apr 11.

Department of Microbiology and Department of Medical Science, College of Medicine, Chungnam National University, Daejeon 35015, Korea.

subsp (MAP) is a causative agent of chronic granulomatous bowel disease in animals and is associated with various autoimmune diseases in humans including Crohn's disease. A good understanding of the host-protective immune response and antibacterial immunity controlled by MAP and its components may contribute to the development of effective control strategies. MAP1889c was identified as a seroreactive antigen in Crohn's disease patients. Read More

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http://dx.doi.org/10.3390/cells9040944DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7226993PMC