20,156 results match your criteria Mutation Research - Fundamental and Molecular Mechanisms of Mutagenesis [Journal]


Chimeric mice with human hepatocytes: A new system for genotoxicity studies.

Mutat Res 2019 Mar 14;839:9-12. Epub 2019 Jan 14.

makoto international consulting, 4-23-3-1, Kami-Imaizumi, Ebina-shi, Kanagawa, 243-0431, Japan. Electronic address:

Genotoxicity assays are characterized by a method, an in vitro or in vivo target, and an endpoint. Many cell types have been used as targets, including bacterial cells, cultured mammalian cells, and rodent cells in vivo. Human cells are the most important target for evaluating the risk to humans associated with exposure to chemicals. Read More

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http://dx.doi.org/10.1016/j.mrgentox.2019.01.003DOI Listing
March 2019
1 Read

Transcriptional response of murine bone marrow cells to total-body carbon-ion irradiation.

Mutat Res 2019 Mar 26;839:49-58. Epub 2019 Jan 26.

School of Life Science and Engineering, Lanzhou University of Technology, Lanzhou, 730000, China.

The need to understand the health effects of heavy ion irradiation is motivated by the use of this modality in radiotherapy and by the potential for exposure during space missions. We have studied the effects of carbon-ion total-body irradiation on the hematopoietic system of the mouse and, in particular, the transcriptional response of bone marrow (BM) cells. Carbon-ion irradiation caused BM cell DNA damage, apoptosis, elevated ROS, and myelosuppression. Read More

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http://dx.doi.org/10.1016/j.mrgentox.2019.01.014DOI Listing

Ambient fine particulate matter (PM) induces oxidative stress and pro-inflammatory response via up-regulating the expression of CYP1A1/1B1 in human bronchial epithelial cells in vitro.

Mutat Res 2019 Mar 12;839:40-48. Epub 2018 Dec 12.

Department of Environmental Genomics, Jiangsu Key Laboratory of Cancer Biomarkers, Prevention and Treatment, Collaborative Innovation Center for Cancer Personalized Medicine, School of Public Health, Nanjing Medical University, Nanjing, China; Department of Genetic Toxicology, The Key Laboratory of Modern Toxicology of Ministry of Education, Center for Global Health, School of Public Health, Nanjing Medical University, Nanjing, China. Electronic address:

We investigated the mechanism responsible for the oxidative stress and pro-inflammatory response triggered by PM collected from Nanjing of China. Two human bronchial epithelia cell lines (HBE and BEAS-2B) were used. Human gene expression profile microarray was performed to investigate the alteration of gene expression in PM-treated HBE cells. Read More

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http://dx.doi.org/10.1016/j.mrgentox.2018.12.005DOI Listing

Genotoxicity of (+)- and (-)-usnic acid in mice.

Mutat Res 2019 Mar 21;839:36-39. Epub 2019 Jan 21.

Research Zakusov Institute of Pharmacology, Baltiyskaya 8, Moscow 125315, Russia.

Usnic acid, which is the most widespread and well-studied secondary lichen compound, has antibacterial and cytotoxic effects. Usnic acid is present in lichens as the (+)- and (-)-enantiomers, which have different biological activities. We used a DNA-comet assay to determine the genotoxic effect of (+)- and (-)-usnic acid in the liver and kidney cells of mice. Read More

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http://dx.doi.org/10.1016/j.mrgentox.2019.01.010DOI Listing

A comparison of transgenic rodent mutation and in vivo comet assay responses for 91 chemicals.

Mutat Res 2019 Mar 18;839:21-35. Epub 2019 Jan 18.

MilliporeSigma, BioReliance Toxicology Testing Services, Rockville, MD, USA.

A database of 91 chemicals with published data from both transgenic rodent mutation (TGR) and rodent comet assays has been compiled. The objective was to compare the sensitivity of the two assays for detecting genotoxicity. Critical aspects of study design and results were tabulated for each dataset. Read More

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http://dx.doi.org/10.1016/j.mrgentox.2019.01.007DOI Listing

Association of BER and NER pathway polymorphism haplotypes and micronucleus frequencies with global DNA methylation in benzene-exposed workers of China: Effects of DNA repair genes polymorphisms on genetic damage.

Mutat Res 2019 Mar 17;839:13-20. Epub 2019 Jan 17.

Department of Occupational Health and Toxicology, School of Public Health, Fudan University, 138 Yixueyuan Road, Shanghai, 200032, China. Electronic address:

Objective: The base excision repair (BER) pathway and nucleotide excision repair (NER) pathway play important roles in the repair of benzene-induced genetic damage, and the effects of polymorphisms in these pathways on genetic damage and global DNA methylation are of great interest.

Methods: Ten single nucleotide polymorphisms (SNPs) in the BER (XRCC1: rs25489, rs25487; APE1: rs1130409) and NER pathways (XPA: rs1800975; XPC: rs2228000, rs2228002; XPD: rs13181, rs1799793; XPG: rs17655; ERCC1: rs3212986) were analyzed by a Kompetitive allele-specific PCR (KASP) assay to find associations with cytokinesis-block micronucleus (MN) frequency and global DNA methylation in 294 shoe factory workers and 102 control participants.

Results: Workers who possessed the following genotypes were associated with high MN frequency: rs25487 AA (FR (95% CI): 1. Read More

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http://dx.doi.org/10.1016/j.mrgentox.2019.01.006DOI Listing

XRCC1 deficiency correlates with increased DNA damage and male infertility.

Mutat Res 2019 Mar 15;839:1-8. Epub 2019 Jan 15.

Department of Molecular & Human Genetics, Banaras Hindu University, Varanasi, India. Electronic address:

High fidelity DNA repair is critical to sustain the genomic integrity and quality of developing germ cells. Deficiencies in DNA repair machinery may result in increased DNA damage in germ cell leading to abnormal spermatogenesis and infertility. X-ray repair cross-complementing group 1 (XRCC1) is a testis enriched protein that plays a crucial role in the DNA base excision repair (BER) pathway. Read More

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http://dx.doi.org/10.1016/j.mrgentox.2019.01.004DOI Listing
March 2019
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High concentration of sugars is genotoxic to folate-deficient cells.

Mutat Res 2019 Jan 9;814:15-22. Epub 2019 Jan 9.

School of Life Sciences, The Engineering Research Center of Sustainable Development and Utilization of Biomass Energy, Yunnan Normal University, Kunming, Yunnan, 650500, China. Electronic address:

Patients with type 2 diabetes mellitus (T2DM) are associated with an elevated, but poorly understood baseline of genomic instability (GIN). Expert panels are still debating on whether hyperglycemia is the key element in conferring this high GIN. Since high blood glucose and low blood folate are prevalent in T2DM, we hypothesized that high glucose may work with low folate to induce GIN. Read More

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https://linkinghub.elsevier.com/retrieve/pii/S00275107183010
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http://dx.doi.org/10.1016/j.mrfmmm.2019.01.003DOI Listing
January 2019
4 Reads

Evaluation of 12 mouse marker genes in rat toxicogenomics public data, Open TG-GATEs: Discrimination of genotoxic from non-genotoxic hepatocarcinogens.

Mutat Res 2019 Feb 23;838:9-15. Epub 2018 Nov 23.

Division of Molecular Target and Gene Therapy Products, National Institute of Health Sciences, 3-25-26, Tonomach, Kawasaki-ku, Kawasaki, 210-9501, Japan.

Previously, we proposed 12 marker genes (Aen, Bax, Btg2, Ccnf, Ccng1, Cdkn1a, Gdf15, Lrp1, Mbd1, Phlda3, Plk2 and Tubb4b) to discriminate mouse genotoxic hepatocarcinogens (GTHC) from non-genotoxic hepatocarcinogens (NGTHC). This was determined by qPCR and principal component analysis (PCA), as the aim of an in vivo short-term screening for genotoxic hepatocarcinogens. For this paper, we conducted an application study of the 12 mouse marker genes to rat data, Open TG-GATEs (public data). Read More

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http://dx.doi.org/10.1016/j.mrgentox.2018.11.001DOI Listing
February 2019
1 Read

Micronuclei frequency in peripheral blood lymphocytes and levels of anti-p53 autoantibodies in serum of residents of Kowary city regions (Poland) with elevated indoor concentrations of radon.

Mutat Res 2019 Feb 15;838:67-75. Epub 2018 Dec 15.

Toxicology and Carcinogenesis Dept., Nofer Institute of Occupational Medicine, Łódź, Poland.

Introduction: Ninety four residents of Kowary city (Poland) have been investigated for environmental radon exposure that ranged from 0.24 WLM to 9.6 WLM (activity concentration range: 35-2700 Bq/m). Read More

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http://dx.doi.org/10.1016/j.mrgentox.2018.12.007DOI Listing
February 2019

F-FDG PET/CT scanning: Biological effects on patients: Entrance surface dose, DNA damage, and chromosome aberrations in lymphocytes.

Mutat Res 2019 Feb 19;838:59-66. Epub 2018 Dec 19.

Department of Human Genetics, Sri Ramachandra Institute of Higher Education and Research (Deemed to be University), Porur, Chennai, Tamil Nadu, 600 116, India. Electronic address:

Positron Emission Tomography/Computed Tomography (PET/CT), a combination of PET and CT, is used in tumor staging, therapy planning, and treatment response monitoring. During PET imaging, patients receive low doses of radiation, which can induce an adaptive response and necessitate higher doses for therapeutic efficacy. Higher doses may augment toxicity to normal cells. Read More

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http://dx.doi.org/10.1016/j.mrgentox.2018.12.010DOI Listing
February 2019

Buccal epithelial cell micronuclei: Sensitive, non-invasive biomarkers of occupational exposure to low doses of ionizing radiation.

Mutat Res 2019 Feb 19;838:54-58. Epub 2018 Dec 19.

Faculty of Sciences and Technology, University of the Azores, 9501-801 Ponta Delgada, Portugal; cE3c-ABG, Centre for Ecology, Evolution and Environmental Changes /Azorean Biodiversity Group, University of the Azores, 9501-801 Ponta Delgada, Azores, Portugal. Electronic address:

We have evaluated buccal epithelial cell micronucleus formation as a biomarker of genotoxic damage following occupational exposure to low doses of ionizing radiation. Buccal epithelial cells were collected from 42 occupationally exposed medical personnel and 39 non-exposed individuals (reference group). Each individual in the exposed group was routinely monitored with a personal radiation badge. Read More

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http://dx.doi.org/10.1016/j.mrgentox.2018.12.009DOI Listing
February 2019

Early prediction of liver carcinogenicity due to occupational exposure to pesticides.

Mutat Res 2019 Feb 12;838:46-53. Epub 2018 Dec 12.

Clinical Pathology, National Research Centre, Egypt.

Several studies linked between pesticides exposure and development of liver cancer, through several mechanisms inform of genotoxicity, cytotoxicity, tumor promotion, immunotoxicity and hormonal actions. This study aimed to estimate novel biomarkers for early prediction of liver malignancy due to occupational exposure to pesticides in two groups of workers with different socioeconomic standard (highly educated urban researchers and low educated rural pesticides sprayers). This study included 50 urban researchers and 50 rural pesticides sprayers occupationally exposed to pesticides. Read More

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http://dx.doi.org/10.1016/j.mrgentox.2018.12.004DOI Listing
February 2019
3.680 Impact Factor

Effect of inter-individual variability in human liver cytochrome P450 isozymes on cyclophosphamide-induced micronucleus formation.

Mutat Res 2019 Feb 5;838:37-45. Epub 2018 Dec 5.

Medicinal Safety Research Laboratories, Daiichi Sankyo Co., Ltd., 1-16-13 Kitakasai, Edogawa-ku, Tokyo, 134-8630, Japan.

We investigated the relationship between metabolic activities of cytochrome P450 (CYP) isozymes present in microsomal fractions derived from the livers of 78 donors and micronucleus induction by cyclophosphamide (CPA). Consequently, a wide inter-individual variation in CYP activities was observed among the 78 donors. The CYP activities were partially correlated with the metabolic phenotypes predicted for the donors based on their single nucleotide polymorphisms. Read More

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http://dx.doi.org/10.1016/j.mrgentox.2018.11.016DOI Listing
February 2019

Cytotoxic and genotoxic effects of environmental relevant concentrations of bisphenol A and interactions with doxorubicin.

Mutat Res 2019 Feb 27;838:28-36. Epub 2018 Nov 27.

Escola Superior de Tecnologia da Saúde de Lisboa - Instituto Politécnico de Lisboa (ESTeSL-IPL), Av. D. João II, lote 4.69.01, 1990-096, Parque das Nações, Lisboa, Portugal; Health and Technology Research Center, Escola Superior de Tecnologia da Saúde de Lisboa - Instituto Politécnico de Lisboa (ESTeSL-IPL), Av. D. João II, lote 4.69.01, 1990-096, Parque das Nações, Lisboa, Portugal; Research Center LEAF - Linking Landscape, Environment, Agriculture and Food - Instituto Superior de Agronomia, Universidade de Lisboa, Portugal. Electronic address:

Bisphenol A (BPA) is one of the most widely utilized endocrine disruptors to which humans are exposed, particularity through ingestion. BPA is an aneugenic compound with a putative association to tumorigenesis. Although extensively studied in estrogen responsive cells, information regarding its effects on cells from the upper gastrointestinal tract exposed to free/active forms of BPA is still scarce. Read More

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http://dx.doi.org/10.1016/j.mrgentox.2018.11.009DOI Listing
February 2019
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Genotoxicity evaluation of titanium dioxide nanoparticles using the mouse lymphoma assay and the Ames test.

Mutat Res 2019 Feb 1;838:22-27. Epub 2018 Dec 1.

Eye Institute, Eye and ENT Hospital, College of Medicine, Fudan University, Shanghai, China; Shanghai Key Laboratory of Visual Impairment and Restoration, Science and Technology Commission of Shanghai Municipality, Shanghai, China; NHC Key Laboratory of Myopia (Fudan University), Key Laboratory of Myopia, Chinese Academy of Medical Sciences, Shanghai, China. Electronic address:

Titanium dioxide nanoparticles (TiO-NPs) are widely used in the cosmetics, health, and food industries, but their safety and genotoxicity remain a matter of debate. We investigated whether TiO-NPs could induce gene mutations in mouse lymphoma L5178Y cells and Salmonella typhimurium strains TA97a, TA98, TA100, TA102, and TA1535. Following preliminary tests, 2 mg/mL for the mouse lymphoma gene mutation assay and 1. Read More

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http://dx.doi.org/10.1016/j.mrgentox.2018.11.015DOI Listing
February 2019

Effect of age and sex on the level of DNA strand breaks and oxidatively damaged DNA in human blood cells.

Authors:
Peter Møller

Mutat Res 2019 Feb 27;838:16-21. Epub 2018 Nov 27.

Department of Public Health, Section of Environmental Health, University of Copenhagen, Øster Farimagsgade 5A, DK-1014, Copenhagen K, Denmark. Electronic address:

DNA damage measured by the comet assay is a well-established biomarker in studies on environmental and occupational exposures, dietary factors and clinical outcomes. Age and sex are typically regarded as confounding factors that are controlled by either selective inclusion criteria of subjects or adjustment in the statistical analysis. This review assesses the influence of age and sex on levels of DNA damage in leukocytes in study populations of healthy subjects. Read More

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https://linkinghub.elsevier.com/retrieve/pii/S13835718183020
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http://dx.doi.org/10.1016/j.mrgentox.2018.11.010DOI Listing
February 2019
2 Reads

Markedly enhanced micronucleus induction by 1,2-dimethylhydrazine dihydrochloride in colonic cells of rats with bacterial colonization in the intestine.

Authors:
Wakako Ohyama

Mutat Res 2019 Feb 20;838:1-8. Epub 2018 Nov 20.

Yakult Central Institute, Yakult Honsha Co., Ltd., 5-11 Izumi, Kunitachi-shi, Tokyo, 186-8650, Japan. Electronic address:

To investigate how intestinal bacteria affect host cytogenetic alterations in the early initiation step of colon carcinogenesis, we conducted a comet assay and micronucleus (MN) test using germ-free (GF) and conventionalized (Cvd) rats after a single subcutaneous injection of the carcinogen, 1,2-dimethylhydrazine dihydrochloride (DMH). DNA damage was also determined in the liver in comet assays, as DMH is metabolized and activated in this organ. The time-response patterns of DNA damage in the liver and colon were similar in both rats, and maximum values were observed at 3 h after the treatment. Read More

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http://dx.doi.org/10.1016/j.mrgentox.2018.11.007DOI Listing
February 2019

Molecular interactions and mutational impact upon rhodopsin (G90→D90) for hindering dark adaptation of eye: A comparative structural level outlook for signaling mechanism in night blindness.

Mutat Res 2019 Jan 4;814:7-14. Epub 2019 Jan 4.

Amity Institute of Biotechnology, Amity University, Kolkata, India. Electronic address:

For night blindness, a detailed structural exploration of the interactions among G-protein receptor rhodopsin, transducin and arrestin was performed. Rhodopsin is responsible for dim light vision while a point mutation (G90→D90) results in an adverse change in its photo-transduction. The validated 3D models of the three proteins were utilized, and upon mutation and interactions, rhodopsin attained higher stability (evaluated through thermodynamic energy calculations, electrostatic surface potential and solvent accessible area), thereby participating strongly with transducin. Read More

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https://linkinghub.elsevier.com/retrieve/pii/S00275107183006
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http://dx.doi.org/10.1016/j.mrfmmm.2019.01.001DOI Listing
January 2019
7 Reads

Dimerization defective MODY mutations of hepatocyte nuclear factor 4α.

Mutat Res 2019 Jan 9;814:1-6. Epub 2019 Jan 9.

Section of Structural Biology, Hormel Institute, University of Minnesota, Austin, MN, United States. Electronic address:

HNF4α is a culprit gene product for a monogenic and dominantly-inherited form of diabetes, referred to as MODY1 (Maturity Onset Diabetes of the Young type 1). Reduced HNF4α activities have been linked to impaired insulin secretion and β-cell function. Numerous mutations have been identified from the patients and they have been instructive as to the individual residue's role in protein structure-function and dysfunction. Read More

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https://linkinghub.elsevier.com/retrieve/pii/S00275107183010
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http://dx.doi.org/10.1016/j.mrfmmm.2019.01.002DOI Listing
January 2019
6 Reads

Targeted sequencing to discover germline variants in the BRCA1 and BRCA2 genes in a Russian population and their association with breast cancer risk.

Mutat Res 2019 Jan 29;813:51-57. Epub 2018 Dec 29.

Department of Genetics, Cytology and Bioengineering, Voronezh State University, Voronezh, Russian Federation. Electronic address:

BRCA1 and BRCA2 are tumor suppressor genes involved in the repair of DNA damage and transcriptional regulation of the cell cycle. Alterations in BRCA1/2 lead to production of functionally defective proteins that impair DNA repair. Certain mutant variants of BRCA1/2 are strongly associated with increased risk of breast and ovarian cancers, with emerging data on association with other types of cancer. Read More

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http://dx.doi.org/10.1016/j.mrfmmm.2018.12.005DOI Listing
January 2019
2 Reads

Mutation analysis of ZP1, ZP2, ZP3 and ZP4 genes in 152 Han Chinese samples with ovarian endometriosis.

Mutat Res 2019 Jan 21;813:46-50. Epub 2018 Dec 21.

Key Laboratory of Women's Reproductive Health of Jiangxi Province, Jiangxi Provincial Maternal and Child Health Hospital, Nanchang, Jiangxi 330006, China; Department of Gynecology, Jiangxi Provincial Maternal and Child Health Hospital, Nanchang, Jiangxi 330006, China. Electronic address:

Endometriosis is characterized by the ectopic implant of endometrial tissue outside the uterine cavity and found in ˜35-50% of subfertile women. Previous studies have found that endometriosis had frequent defects in zona pellucida (ZP), and mutations in ZP genes could lead to ZP defects, raising the possibility that mutations in ZP genes might exist in endometriosis. We analyzed a total of 152 Han Chinese samples with ovarian endometriosis for the presence of mutations in the ZP1, ZP2, ZP3 and ZP4 genes. Read More

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https://linkinghub.elsevier.com/retrieve/pii/S00275107183008
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http://dx.doi.org/10.1016/j.mrfmmm.2018.12.003DOI Listing
January 2019
10 Reads

In vivo genotoxicity of 1,4-dioxane evaluated by liver and bone marrow micronucleus tests and Pig-a assay in rats.

Mutat Res 2019 Jan 23;837:8-14. Epub 2018 Sep 23.

Biologics & Immuno-Oncology Laboratories, Daiichi Sankyo Co., Ltd., 1-2-58, Hiromachi, Shinagawa-ku, Tokyo, 140-8710, Japan.

1,4-Dioxane, used widely as a solvent in the manufacture of chemicals and as a laboratory reagent, induced liver adenomas and carcinomas in mice and rats, and nasal tumors in rats in several long-term studies. 1,4-Dioxane has been reported to be non-genotoxic in vitro, and there is no clear conclusion concerning its in vivo genotoxicity in rodents. In the present study, we investigated the ability of 1,4-dioxane to induce micronuclei in the liver and bone marrow of rats. Read More

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http://dx.doi.org/10.1016/j.mrgentox.2018.09.004DOI Listing
January 2019
2 Reads

Evaluation of 4-(methylnitrosamino)-1-(3-pyridyl)-1-butanone (NNK) mutagenicity using in vitro and in vivo Pig-a assays.

Mutat Res 2019 Jan 29;837:65-72. Epub 2018 Oct 29.

U.S. Food and Drug Administration, Division of Genetic and Molecular Toxicology, National Center for Toxicological Research, USA. Electronic address:

4-(Methylnitrosamino)-1-(3-pyridyl)-1-butanone (NNK) is a genotoxic carcinogen found in tobacco and tobacco smoke. Several in vitro and in vivo assays have been used for evaluating the genotoxicity of tobacco smoke and tobacco smoke constituents like NNK, yet it is not clear which in vitro assays are most appropriate for extrapolating the in vitro responses of these test agents to animal models and humans. The Pig-a gene mutation assay can be performed in vitro, in laboratory animals, and in humans, a potential benefit in estimating in vivo responses from in vitro data. Read More

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http://dx.doi.org/10.1016/j.mrgentox.2018.10.007DOI Listing
January 2019
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Cytoprotective and genotoxic effects of vitamins K1 and B1 on irinotecan in vitro.

Mutat Res 2019 Jan 26;837:60-64. Epub 2018 Oct 26.

Lab. of Med. Biol. and Genetics, Medical Faculty, Aristotle University of Thessaloniki, 54124, Greece. Electronic address:

Cultured human lymphocytes were treated with vitamins K and B, potential anticancer agents, either alone or in combination with irinotecan, a semisynthetic analogue of camptothecin. The frequency of sister chromatid exchanges (SCEs) was measured as an indicator of genotoxicity and the proliferation rate index (PRI) and mitotic index (MI) was measured as indicators of cytostatic effect. Vitamin K alone did not induce SCEs at the concentrations tested and combined with irinotecan does not increase SCE rates induced by irinotecan alone. Read More

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http://dx.doi.org/10.1016/j.mrgentox.2018.10.006DOI Listing
January 2019
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Analysis of historical negative control group data from the in vitro micronucleus assay using human lymphocytes.

Mutat Res 2019 Jan 18;837:52-59. Epub 2018 Sep 18.

ILSI Health and Environmental Sciences Institute (HESI), 1156 15th Street NW, 2nd Floor, Washington, DC 20005, USA.

A database of the micronuclei counts was built up for historical negative control data from human lymphocyte in vitro micronuclei tests (MnVit) carried out in 8 laboratories with experience of the method. The mean incidence of micronucleated cells (mnt)/1000 cells ranged from 2.2/1000 to 15. Read More

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http://dx.doi.org/10.1016/j.mrgentox.2018.08.009DOI Listing
January 2019
1 Read
3.680 Impact Factor

Genotoxicity of textile dye C.I. Disperse Blue 291 in mouse bone marrow.

Mutat Res 2019 Jan 12;837:48-51. Epub 2018 Oct 12.

UNESP - São Paulo State University, Medical School, Department Pathology Rubião Júnior, 18.618-687, Botucatu, São Paulo, Brazil. Electronic address:

Color Index (C.I.) Disperse Blue 291 (DB291) is an azo dye used by the textile industry. Read More

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http://dx.doi.org/10.1016/j.mrgentox.2018.10.003DOI Listing
January 2019
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Increased genomic damage and vitamin B status in inflammatory bowel disease patients: A case-control, prospective, pilot study.

Mutat Res 2019 Jan 11;837:42-47. Epub 2018 Oct 11.

Divison of Gastroenterology, Department of Internal Medicine, Gachon University, Gil Medical Center, Incheon, South Korea.

Vitamin B deficiency in patients with inflammatory bowel disease (IBD) is well-documented; however, few studies have explored genomic damage in patients with IBD using the cytokinesis-block micronucleus cytome (CBMN-Cyt) assay. This study investigated the frequency of micronuclei (MNi) using the CBMN-Cyt assay and the level of vitamin B in patients with IBD. This prospective study was conducted in 15 patients with ulcerative colitis, 15 patients with Crohn's disease, and 30 healthy controls from one tertiary hospital. Read More

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http://dx.doi.org/10.1016/j.mrgentox.2018.10.002DOI Listing
January 2019
3 Reads

Environmental exposure of humans to bromide in the Dead Sea area: Measurement of genotoxicy and apoptosis biomarkers.

Mutat Res 2019 Jan 26;837:34-41. Epub 2018 Sep 26.

Department of Clinical Pharmacy, Faculty of Pharmacy, Jordan University of Science and Technology, P.O. Box 3030, Irbid, 22110, Jordan.

Bromide (Br) is a bromine atom with a negative charge which is released mainly in the production of pesticides and flame retardants. It is also found naturally in seawater. Br¯ has been associated with many detrimental effects such as respiratory problems, gastric hemorrhages, and dermal burns. Read More

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http://dx.doi.org/10.1016/j.mrgentox.2018.09.006DOI Listing
January 2019
2 Reads

Comparison of DNA damages in blood lymphocytes of indoor swimming pool lifeguards with non-lifeguards athletes.

Mutat Res 2019 Jan 24;837:29-33. Epub 2018 Sep 24.

Department of Hematology and Blood Banking, Faculty of Medicine, Gonabad University of Medical Sciences, Gonabad, Iran. Electronic address:

Chlorination has been used as a major disinfectant process for swimming pool water in many countries. The purpose of this study is to compare the DNA damage of the blood lymphocytes in indoor pool lifeguards with non-lifeguards athletes. We performed a study in which the participants were Gonabad's lifeguards. Read More

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http://dx.doi.org/10.1016/j.mrgentox.2018.09.005DOI Listing
January 2019
1 Read

A meta-analysis of epidemiologic studies of occupationally exposed styrene workers and micronuclei levels.

Mutat Res 2019 Jan 21;837:15-28. Epub 2018 Sep 21.

Ramboll, 124 West Capitol Avenue Suite 1605 Little Rock, AR 72201, USA.

Previous reviews and meta-analyses have reached different conclusions on whether high styrene exposure increase micronucleus frequencies. The most recent meta-analysis reports an increase in these frequencies related to styrene. We update this meta-analysis of micronucleus frequencies with additional studies not previously included, eliminate double counting of study subjects appearing in more than one publication, considered levels of styrene exposures in the analysis, assess publication bias, and examine consistency of findings across studies. Read More

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http://dx.doi.org/10.1016/j.mrgentox.2018.08.011DOI Listing
January 2019
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Integration of micronucleus tests with a gene mutation assay in F344 gpt delta transgenic rats using benzo[a]pyrene.

Mutat Res 2019 Jan 16;837:1-7. Epub 2018 Sep 16.

Suntory Wellness Limited, 8-1-1 Seikadai, Seika-cho, Soraku-gun, Kyoto, 619-0284, Japan.

Reduction of the number of animals used in in vivo genotoxicity tests is encouraged. For this purpose, we conducted integrated toxicity tests combining gene mutation assays with multiple-organ micronucleus (MN) tests (peripheral blood, bone marrow, liver, and colon) in F344 gpt delta transgenic (Tg) rats. Seven-week-old male F344 gpt delta rats were orally administered 62. Read More

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http://dx.doi.org/10.1016/j.mrgentox.2018.09.003DOI Listing
January 2019
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Eggplant fruits protect against DNA damage and mutations.

Mutat Res 2019 Jan 21;813:39-45. Epub 2018 Dec 21.

Department of Pharmacology, Faculty of Pharmacy, Rangsit University, Pathum Thani, 12000, Thailand.

Eggplant belongs to the Solanaceae family, and it has an important antioxidant capability that has been shown to counteract oxidation, which is harmful to health and many diseases. In this present study, we evaluated the antigenotoxic effects of six eggplants ((Solanum aculeatissimum Jacq. 'Ma-khuea-lueang'; ML), (Solanum aculeatissimum Jacq. Read More

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http://dx.doi.org/10.1016/j.mrfmmm.2018.12.004DOI Listing
January 2019
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Implication of GATA4 synonymous variants in congenital heart disease: A comprehensive in-silico approach.

Mutat Res 2019 Jan 15;813:31-38. Epub 2018 Dec 15.

Cytogenetics Laboratory, Department of Zoology, Institute of Science, Banaras Hindu University, Varanasi, Uttar Pradesh, India. Electronic address:

Synonymous variations, previously considered as neutral, are recently shown to have a significant impact on mRNA structure and stability thereby affecting protein expression and function. Their role in disease pathogenesis is also emerging. GATA4 is an important transcription factor involved in cardiac development and a well-known candidate gene associated with congenital heart disease (CHD). Read More

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http://dx.doi.org/10.1016/j.mrfmmm.2018.12.002DOI Listing
January 2019
1 Read
3.680 Impact Factor

Role of endonuclease III enzymes in uracil repair.

Mutat Res 2019 Jan 14;813:20-30. Epub 2018 Dec 14.

Department of Genetics and Biochemistry, Clemson University, Room 049 Life Sciences Facility, 190 Collings Street, Clemson, SC 29634, USA. Electronic address:

Endonuclease III is a DNA glycosylase previously known for its repair activity on oxidative pyrimidine damage. Uracil is a deamination product derived from cytosine. Uracil DNA N-glycosylase (UNG) and mismatch-specific uracil DNA glycosylase (MUG) are two known repair enzymes with enzymatic activity on uracil in E. Read More

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https://linkinghub.elsevier.com/retrieve/pii/S00275107183010
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http://dx.doi.org/10.1016/j.mrfmmm.2018.12.001DOI Listing
January 2019
6 Reads

Is level of acetylation directly correlated to radiation sensitivity of cancer cell?

Mutat Res 2019 Jan 22;813:13-19. Epub 2018 Nov 22.

Key Laboratory of High Magnetic Field and Ion Beam Physical Biology, Institute of Technical Biology and Agriculture Engineering, Hefei Institutes of Physical Science, Chinese Academy of Sciences, Hefei, 230031, China; University of Science &Technology of China, Hefei, 230026, China. Electronic address:

It is known that histone deacetylase inhibitors (HDACis) can modify acetylation of tumor cells and affect radiation sensitivity, or, radiosensitivity. While previous studies showed that trichostatin A (TSA, a typical HDACi) could enhance cell acetylation and so be used as radiation-sensitizer in radiotherapy, we questioned if the radiosensitivity is correlated with cellular acetylation directly. So we inspected radiation response of HeLa cells treated with TSA and investigated the time-dependent effect on radiosensitivity. Read More

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http://dx.doi.org/10.1016/j.mrfmmm.2018.11.001DOI Listing
January 2019
1 Read

A molecular dynamics based investigation reveals the role of rare Ribonuclease 4 variants in amyotrophic lateral sclerosis susceptibility.

Mutat Res 2019 Jan 29;813:1-12. Epub 2018 Nov 29.

Kusuma School of Biological Sciences, Indian Institute of Technology Delhi, Hauz Khas, New Delhi, 110016, India. Electronic address:

Missense mutations in certain genes of the Ribonuclease (RNASE) superfamily cause amyotrophic lateral sclerosis (ALS) through loss of either ribonucleolytic or nuclear translocation or both of these activities. While rare ANG/RNASE5 variants have been previously shown to be ALS causative, it is not yet known if any of the reported rare RNASE4 variants can also trigger ALS. The study aims to understand whether rare variants of RNASE4 can manifest ALS through similar loss-of-function mechanisms. Read More

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http://dx.doi.org/10.1016/j.mrfmmm.2018.11.002DOI Listing
January 2019
1 Read

Aflatoxin B metabolism: Regulation by phase I and II metabolizing enzymes and chemoprotective agents.

Mutat Res 2018 Oct - Dec;778:79-89. Epub 2018 Oct 29.

Department of Animal Nutrition and Feed Science, College of Animal Science and Technology, Huazhong Agricultural University, Wuhan, Hubei, 430070, China. Electronic address:

Aflatoxin B (AFB) widely contaminates staple food and feed crops and is well-known as the most potent natural hepatocarcinogen in humans and domesticated animals. This review highlights significant advances in our understanding of the pivotal role of phase I and II metabolizing enzymes in the bioactivation and detoxification of AFB and its metabolites across species. In humans, cytochrome P450 (CYP) 1A2, CYP3A4, CYP3A5, and CYP3A7 in liver and CYP2A13 in lung are essential for the bioactivation of AFB to the extremely toxic exo-AFB-8,9-epoxide (AFBO), whereas CYP1A1, CYP1A2, CYP2A6, and CYP3A4 are important in the turkey and duck, CYP1A1 and CYP2A6 are important in the chicken and quail, CYP3A11 and CYP3A13 are important in mice, and CYP2A5 are important in the hamster. Read More

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http://dx.doi.org/10.1016/j.mrrev.2018.10.002DOI Listing
October 2018
8 Reads

Pathophysiological mechanisms linking F-box only protein 7 (FBXO7) and Parkinson's disease (PD).

Mutat Res 2018 Oct - Dec;778:72-78. Epub 2018 Oct 17.

Department of Research, National Neuroscience Institute, 11 Jalan Tan Tock Seng, 308433, Singapore; Department of Neurology, Singapore General Hospital, Outram Road, 169608, Singapore; Signature Research Program in Neuroscience and Behavioural Disorders, Duke-NUS Medical School, 8 College Road, 169857, Singapore. Electronic address:

Mutations of F-box only protein 7 (FBXO7) gene are associated with a severe form of autosomal recessive juvenile Parkinson's disease (PD) (PARK15) with clinical features of Parkinsonian-Pyramidal syndrome (PPS). FBXO7 is an adaptor protein in SCF ubiquitin E3 ligase complex that recognizes and mediates degradative or non-degradative ubiquitination of substrates. The FBXO7 protein can regulate cell cycle, proliferation, mitochondrial and proteasome functions via interactions with multiple target proteins. Read More

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http://dx.doi.org/10.1016/j.mrrev.2018.10.001DOI Listing
October 2018
7 Reads
3.680 Impact Factor

Genetic landscape of gallbladder cancer: Global overview.

Mutat Res 2018 Oct - Dec;778:61-71. Epub 2018 Aug 23.

Laboratory Oncology Unit, Rotary Cancer Center, All India Institute of Medical Sciences, Ansari Nagar, New Delhi, India.

Gallbladder cancer (GBC) is a rare malignancy of biliary tract cancer (BTC), characterized by late presentation and poor prognosis. It exhibits wide geographical as well as ethnical variations. So, diverse epidemiology along with etiological factors have been discussed in the current article. Read More

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http://dx.doi.org/10.1016/j.mrrev.2018.08.003DOI Listing
August 2018
14 Reads
3.680 Impact Factor

Line-1: Implications in the etiology of cancer, clinical applications, and pharmacologic targets.

Mutat Res 2018 Oct - Dec;778:51-60. Epub 2018 Sep 19.

Department of Medicine, Division of Pulmonary, Allergy, Critical Care and Sleep Medicine, College of Medicine, Tucson, University of Arizona, USA; Center for Applied Genetics and Genomic Medicine, University of Arizona, USA; Department of Medicine, Division of Clinical Decision Support and Data Analytics, College of Medicine, Phoenix, University of Arizona, USA. Electronic address:

Long interspersed nuclear elements-1 (Line-1 or L1) accounts for approximately 17% of the human genome. The majority of L1s are inactive, but ∼100 remain retrotransposon competent (RC-L1) and able to retrotranspose through RNA intermediates to different locations of the genome. L1 is involved in both disease initiation and progression via retrotransposition dependent and independent mechanisms. Read More

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http://dx.doi.org/10.1016/j.mrrev.2018.09.003DOI Listing
September 2018
1 Read

Molecular genetics of the POMT1-related muscular dystrophy-dystroglycanopathies.

Mutat Res 2018 Oct - Dec;778:45-50. Epub 2018 Sep 12.

Center for Experimental Medicine, the Third Xiangya Hospital, Central South University, Changsha, PR China. Electronic address:

Protein O-mannosyltransferase 1 (POMT1) is a critical enzyme participating in the first step of protein O-mannosylation. Mutations in the coding gene, POMT1, have been described to be related to a series of autosomal recessive disorders associated with defective alpha-dystroglycan glycosylation, later termed muscular dystrophy-dystroglycanopathies (MDDGs). MDDGs are characterized by a broad phenotypic spectrum of congenital muscular dystrophy or later-onset limb-girdle muscular dystrophy, accompanied by variable degrees of intellectual disability, brain defects, and ocular abnormalities. Read More

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http://dx.doi.org/10.1016/j.mrrev.2018.09.002DOI Listing
September 2018
9 Reads

Sperm epigenome as a marker of environmental exposure and lifestyle, at the origin of diseases inheritance.

Mutat Res 2018 Oct - Dec;778:38-44. Epub 2018 Sep 7.

Inserm, U1065, Centre Méditerranéen de Médecine Moléculaire (C3M), Team 5, Nice, F-06204, France.

Paternal exposure to environmental challenges plays a critical role in the offspring's future health and the transmission of acquired traits through generations. This review summarizes our current knowledge in the new field of epigenomic paternal transmission of health and disease. Epidemiological studies identified that paternal ageing or challenges (imbalanced diets, stress, toxicants, cigarette smoke, alcohol) increased the risk of offspring to develop diseases such as cancer, metabolic, cardiovascular, and neurological diseases. Read More

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http://dx.doi.org/10.1016/j.mrrev.2018.09.001DOI Listing
September 2018
6 Reads

DNA damage in obesity: Initiator, promoter and predictor of cancer.

Mutat Res 2018 Oct - Dec;778:23-37. Epub 2018 Aug 17.

Department of Biomedical Sciences, Faculty of Science and Technology, University of Westminster, 115 New Cavendish Street, London W1W 6UW, UK. Electronic address:

Epidemiological evidence linking obesity with increased risk of cancer is steadily growing, although the causative aspects underpinning this association are only partially understood. Obesity leads to a physiological imbalance in the regulation of adipose tissue and its normal functioning, resulting in hyperglycaemia, dyslipidaemia and inflammation. These states promote the generation of oxidative stress, which is exacerbated in obesity by a decline in anti-oxidant defence systems. Read More

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http://dx.doi.org/10.1016/j.mrrev.2018.08.002DOI Listing
August 2018
9 Reads

Radiation-induced bystander and systemic effects serve as a unifying model system for genotoxic stress responses.

Mutat Res 2018 Oct - Dec;778:13-22. Epub 2018 Aug 17.

University Hospital Centre Hamburg-Eppendorf, Department of Radiotherapy and Radiation Oncology, Hamburg, Germany.

This review summarises our current understanding of the radiation-induced bystander/systemic effect (RIBE) as well as other types of intercellular reactions induced by malignant tumours, chemotherapy, photodynamic stress and the microbiome. On the basis of striking similarities between these different types of responses RIBE is proposed as a prototype model of a unifying genotoxic stress response system. The early bystander response is initiated by a mitochondria-dependent increase of reactive oxygen species (ROS) and triggers a complex intercellular signalling cascade leading to a sustained increase of cellular DNA damage. Read More

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http://dx.doi.org/10.1016/j.mrrev.2018.08.001DOI Listing
August 2018
18 Reads

Epigenetics: An emerging field in the pathogenesis of nonalcoholic fatty liver disease.

Mutat Res 2018 Oct - Dec;778:1-12. Epub 2018 Aug 8.

Chromatin and Epigenetics Lab, Department of Biotechnology, University of Kashmir, Srinagar, Jammu and Kashmir 190006, India. Electronic address:

Nonalcoholic fatty liver disease (NAFLD) is a major health concern associated with increased mortality due to cardiovascular disease, type II diabetes, insulin resistance, liver disease, and malignancy. The molecular mechanism underlying these processes is not fully understood but involves hepatic fat accumulation and alteration of energy metabolism and inflammatory signals derived from various cell types including immune cells. During the last two decades, epigenetic mechanisms have emerged as important regulators of chromatin alteration and the reprogramming of gene expression. Read More

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https://linkinghub.elsevier.com/retrieve/pii/S13835742173009
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http://dx.doi.org/10.1016/j.mrrev.2018.07.002DOI Listing
August 2018
8 Reads

Polymorphisms in IMPDH2, UGT2B7, and CES2 genes influence the risk of graft rejection in kidney transplant recipients taking mycophenolate mofetil.

Mutat Res 2018 Dec 1;836(Pt B):97-102. Epub 2018 Jun 1.

Department of General Biology, Center of Biological Sciences, State University of Londrina, Londrina, Paraná, Brazil. Electronic address:

The immunosuppressant mycophenolic acid (MPA), derived from the prodrug mycophenolate mofetil (MMF), is a drug used widely by kidney transplant recipients. This drug selectively inhibits inosine monophosphate dehydrogenase that controls the proliferation of lymphocytes, aiding in the prevention of rejection of the transplanted organ. Polymorphisms in key genes involved in MMF metabolism may alter the function of the enzymes encoded by them and contribute to interindividual variability in the response to the drug and its efficacy. Read More

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http://dx.doi.org/10.1016/j.mrgentox.2018.06.008DOI Listing
December 2018
2 Reads

BCL2 and miR-181a transcriptional alterations in umbilical-cord blood cells can be putative biomarkers for obesity.

Mutat Res 2018 Dec 2;836(Pt B):90-96. Epub 2018 Jun 2.

UNESP - São Paulo State University, Medical School, Botucatu, SP, Brazil.

Several findings suggest that in utero stressor stimuli can alter fetal development by promoting transcriptional changes, and predisposing the neonate to diseases later in life. This study aimed to investigate whether a hyperglycemic environment in pregnant women with gestational diabetes mellitus (GDM) is able to cause fetal genetic alterations and predispose neonates to obesity. Transcriptional alteration of SIRT1, TP53 and BCL2 genes, miR-181a (a SIRT1 or BCL2 regulator) and telomere length were evaluated in placental and umbilical-cord blood cells. Read More

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http://dx.doi.org/10.1016/j.mrgentox.2018.06.009DOI Listing
December 2018
8 Reads

Base excision repair (OGG1 and XRCC1) and metabolism (PON1) gene polymorphisms act on modulation of DNA damage and immune parameters in tobacco farmers.

Mutat Res 2018 Dec 4;836(Pt B):9-18. Epub 2018 Apr 4.

Laboratory of Toxicological Genetics, Postgraduate Program in Cellular and Molecular Biology Applied to Health (PPGBioSaúde), Lutheran University of Brazil (ULBRA), Av. Farroupilha, 8001, building 22, 4th floor, Canoas, Brazil. Electronic address:

Pesticides are one of the most frequently investigated chemical, due to their multiple uses in agricultural and public health areas. This study evaluates lymphocytes CBMN (cytokinesis-block micronucleus cytome assay), inflammatory markers, inorganic elements in blood samples, and the relationship of these parameters with XRCC1Arg194Trp, OGG1Ser326Cys and PON1Gln192Arg polymorphisms in a population of tobacco farmers. The study population comprised 129 agricultural workers exposed to pesticides and 91 nonexposed. Read More

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https://linkinghub.elsevier.com/retrieve/pii/S13835718173019
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http://dx.doi.org/10.1016/j.mrgentox.2018.04.001DOI Listing
December 2018
9 Reads

Single nucleotide polymorphisms in ATM, TNF-α and IL6 genes and risk of radiotoxicity in breast cancer patients.

Mutat Res 2018 Dec 7;836(Pt B):84-89. Epub 2018 Jun 7.

Departamento de Física, Facultad de Ciencias Exactas, Universidad Nacional de La Plata, Calle 60 Nº 480, CP 1900, La Plata, Argentina; IGEVET - Instituto de Genética Veterinaria "Ing. Fernando N. Dulout" (UNLP-CONICET LA PLATA), Facultad de Ciencias Veterinarias UNLP, Calle 60 y 118 s/n (1900) La Plata, Buenos Aires, Argentina.

Although oncological therapies have improved in the last decades, breast cancer (BC) remains a serious health problem worldwide. Radiotherapy (RT) is one of the most frequently used treatments for cancer aimed at eliminating tumor cells. However, it can also alter the surrounding normal tissue, especially the skin, and patient reactions may vary as a result of extrinsic and intrinsic factors. Read More

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https://linkinghub.elsevier.com/retrieve/pii/S13835718173020
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http://dx.doi.org/10.1016/j.mrgentox.2018.06.005DOI Listing
December 2018
6 Reads