76,741 results match your criteria Musculoskeletal Tumors Staging And Treatment Planning


The treatment of central sensitization in an adolescent using pain neuroscience education and graded exposure to activity: A case report.

Physiother Theory Pract 2018 Dec 12:1-11. Epub 2018 Dec 12.

b Intermountain Healthcare , Orem Community Hospital , Orem , UT , USA.

Chronic pain affects 1.7 million children in the United States, and its effects often linger into adulthood. Unfortunately, chronic pediatric pain is often undertreated. Read More

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December 2018
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A new decision tree for diagnosis of osteoarthritis in primary care: international consensus of experts.

Aging Clin Exp Res 2018 Dec 11. Epub 2018 Dec 11.

Service de rééducation et réadaptation de l'appareil locomoteur et des pathologies du rachis, Laboratoire de Pharmacologie, Toxicologie et Signalisation Cellulaire, Univ. Paris Descartes, PRES Sorbonne Paris Cité, Hôpital Cochin, Assistance Publique -Hôpitaux de Paris, INSERM UMR-S 1124, UFR Biomédicale des Saints Pères, Paris, France.

Background And Aims: Although osteoarthritis (OA) is managed mainly in primary care, general practitioners (GPs) are not always trained in its diagnosis, which leads to diagnostic delays, unnecessary resource utilization, and suboptimal patient outcomes.

Methods: To address this situation, an International Rheumatologic Board (IRB) of 8 experts from 3 continents developed guidelines for the diagnosis of OA in primary care. The focus was three major topologies: hip, knee, and hand/finger OA. Read More

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December 2018

The effects of radiosynoviorthesis in pigmented villonodular synovitis of the knee.

Arch Orthop Trauma Surg 2018 Dec 11. Epub 2018 Dec 11.

Department of Nuclear Medicine, University Hospital, LMU Munich, Munich, Germany.

Introduction: Tenosynovial giant-cell tumor also known as pigmented villonodular synovitis (PVS) is a benign but aggressive synovial proliferative disease most often affecting the knee joint. The mainstay of therapy is surgical resection. Due to a high rate of local recurrence, radiosynoviorthesis (RSO) is used as an adjuvant method in many cases. Read More

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December 2018

Reliability of OMERACT ultrasound elementary lesions in gout: results from a multicenter exercise.

Rheumatol Int 2018 Dec 11. Epub 2018 Dec 11.

Rheumatology Unit, Instituto de Rehabilitación Psicofísica, Echeverria 955, Buenos Aires, C1428DQG, Argentina.

The aim of this study was to evaluate the reliability of the outcome measures in rheumatology (OMERACT) definitions for ultrasound (US) elementary lesions in gout through an image reading exercise. Images from patients with gout (static images and videos) were collected. As an initial step, we carried out a image reading exercise within the experts of the Pan-American League of Associations for Rheumatology (PANLAR) US Study Group (n = 16). Read More

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December 2018

What abdominal radiologists should know about extragenital endometriosis-associated neuropathy.

Abdom Radiol (NY) 2018 Dec 11. Epub 2018 Dec 11.

Department of Radiology, Hospital Sírio-Libanês, Adma Jafet, 91, Bela Vista, São Paulo, SP, 01308-050, Brazil.

Purpose: The aim of this study is to provide an overview of endometriosis-associated neuropathy and to review main anatomical concepts of intrapelvic peripheral nerves.

Methods: In this pictorial essay, we review the anatomy of pelvic nerves and imaging features of endometriosis-associated neuropathy. We also evaluate clinical findings, imaging features, and outcome of seven patients with endometriosis-associated neuropathy. Read More

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December 2018

Pre-season Fitness Level and Injury Rate in Professional Soccer - A Prospective Study.

Sports Med Int Open 2018 Jun 22;2(3):E84-E90. Epub 2018 Aug 22.

Child Health & Sports Center, Meir Medical Center, Pediatrics, Sackler School of Medicine, Tel Aviv University Kfar Saba, Israel.

The aim of the present study was to assess prospectively the effect of pre-season fitness on injury rate during the competitive season among professional soccer players. Thirty-one players participated in the study during two consecutive competitive seasons (2015-16 and 2016-17; a squad of 22 players in each season). During the 6-week pre-season training period (8 training sessions and a friendly match every week, 14-18 training hours/week) there was a significant improvement in VO max, a significant increase in ideal and total sprint time and no change in vertical jump, flexibility and repeated sprint-test performance decrement. Read More

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Innovative Techniques to Enhance Musculoskeletal Surgery Outcomes.

Biomed Res Int 2018 13;2018:7189240. Epub 2018 Nov 13.

Humanitas University Department of Biomedical Sciences, Via Manzoni 113, 20089 Rozzano, Milan, Italy.

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November 2018

Osgood-Schlatter Disease Unveiled Under High-frequency Ultrasonogram.

Authors:
Md Abu B Siddiq

Cureus 2018 Oct 4;10(10):e3411. Epub 2018 Oct 4.

Physical Medicine and Rheumatology, Brahmanbaria Medical College, Brahmanbaria, BGD.

Osgood-Schlatter disease is a painful condition, affecting the tibial tuberosity of physically active children with a painful bump that aggravates with repetitive impacts over the affected area during exercise, sports, or even usual daily activities. The condition is usually unilateral; however, bilateral presentation is not unlikely. In addition to clinical features, a unique radiological finding appears worthy in terms of accurate diagnosis. Read More

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October 2018

Unusual Etiology of Acute Wrist Pain: Acute Calcific Tendonitis of the Flexor Carpi Ulnaris Mimicking an Infection.

Authors:
Man R Shim

Case Rep Orthop 2018 14;2018:2520548. Epub 2018 Nov 14.

Department of Medicine, Rheumatology Division, David Geffen School of Medicine, University of California, Los Angeles, Los Angeles, CA, USA.

Acute calcific tendonitis is a common cause of musculoskeletal pain. However, it seldom affects the hand and wrist. For that reason, it is frequently mistaken for more common etiologies. Read More

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November 2018

Progression of subclinical and clinical cardiovascular disease in a UK SLE cohort: the role of classic and SLE-related factors.

Lupus Sci Med 2018 17;5(1):e000267. Epub 2018 Nov 17.

Arthritis Research UK Centre for Epidemiology, Centre for Musculoskeletal Research, Faculty of Biology Medicine and Health, The University of Manchester, Manchester Academic Health Science Centre, Manchester, UK.

Objectives: We aimed to describe the rate and determinants of carotid plaque progression and the onset of clinical cardiovascular disease (CVD) in a UK SLE cohort.

Methods: Female patients with SLE of white British ancestry were recruited from clinics in the North-West of England and had a baseline clinical and CVD risk assessment including measurement of carotid intima-media thickness (CIMT) and plaque using B-mode Doppler ultrasound. Patients were followed up (>3. Read More

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November 2018

Time Course of Upper Limb Function in Children with Unilateral Cerebral Palsy: A Five-Year Follow-Up Study.

Neural Plast 2018 14;2018:2831342. Epub 2018 Nov 14.

KU Leuven, University of Leuven, Department of Rehabilitation Sciences, Leuven, Belgium.

Knowledge on long-term evolution of upper limb function in children with unilateral cerebral palsy (CP) is scarce. The objective was to report the five-year evolution in upper limb function and identify factors influencing time trends. Eighty-one children (mean age 9 y and 11 mo, SD 3 y and 3 mo) were assessed at baseline with follow-up after 6 months, 1, and 5 years. Read More

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November 2018

Lower Performance in the Six-Minute Walk Test in Obese Youth With Cardiometabolic Risk Clustering.

Front Endocrinol (Lausanne) 2018 27;9:701. Epub 2018 Nov 27.

Department of Public Health, School of Medicine, University of Naples Federico II, Naples, Italy.

Physical fitness is an important index of health. Our aim was to assess whether cardiorespiratory and/or musculoskeletal components of physical fitness were associated with cardiometabolic risk clustering in obese youth, using adapted and validated field tests. We evaluated 252 children and adolescents (132 males, 120 females), mean age 10. Read More

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November 2018

Social hierarchy of pain and its connection to the memory of previously suffered pain.

J Pain Res 2018 21;11:2949-2959. Epub 2018 Nov 21.

Institute for Advanced Social Studies, Spanish National Research Council (IESA/CSIC), Córdoba, Spain,

Background: Pain is a perception conditioned both by the painful experience and by each society's collective imagination. The general objective of the project which this work forms part of it was to discover what citizens think about different aspects of this complex experience. More precisely, this paper's objective is to get to know which is the worst pain that can be suffered according to Spaniards and what determines that hierarchy, bearing in mind that this work has chosen a broad definition of pain, including pains of different origins, namely, physical, psychological, and emotional pain. Read More

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November 2018

A novel RAG1 mutation reveals a critical in vivo role for HMGB1/2 during V(D)J recombination.

Blood 2018 Dec 11. Epub 2018 Dec 11.

School of Molecular and Cellular Biology, University of Leeds, Leeds, United Kingdom;

The Recombination Activating Genes, RAG1 and RAG2, are essential for V(D)J recombination and adaptive immunity. Mutations in these genes often cause immunodeficiency, the severity of which reflects the importance of the altered residue(s) during recombination. Here, we describe a novel RAG1 mutation that causes immunodeficiency in an unexpected way: The mutated protein severely disrupts binding of the accessory protein, HMGB1. Read More

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December 2018

Impaired oral health status on admission is associated with poor clinical outcomes in post-acute inpatients: A prospective cohort study.

Clin Nutr 2018 Nov 30. Epub 2018 Nov 30.

Department of Social Science, National Center for Geriatrics and Gerontology, 35 Gengo, Morioka, Obu, Aichi, 474-8511, Japan.

Background & Aims: Oral health is an integral part of nutrition and rehabilitation. The purpose of this study was to investigate the impact of impaired oral health status on clinical and functional outcomes in post-acute in-hospital rehabilitation.

Methods: We conducted a prospective cohort study of hospitalized patients undergoing rehabilitation at a 225-bed post-acute rehabilitation hospital in Japan. Read More

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November 2018

Icariin inhibits RANKL-induced osteoclastogenesis via modulation of the NF-κB and MAPK signaling pathways.

Biochem Biophys Res Commun 2018 Dec 8. Epub 2018 Dec 8.

Department of Orthopedics, The First Affiliated Hospital of Nanchang University, Artificial Joints Engineering and Technology Research Center of Jiangxi Province, Nanchang, Jiangxi province, 330006, China; Multidisciplinary Therapy Center of Musculoskeletal Tumor, The First Affiliated Hospital of Nanchang University, Nanchang, Jiangxi province, 330006, China. Electronic address:

The receptor activator of nuclear factor-κB (NF-κB) ligand (RANKL)-RANK regulatory axis is a major regulator of osteoclast differentiation and activation. Icariin, a flavonol glycoside isolated from the Epimedium herb, has been reported to prevents bone loss in ovariectomized mice and inhibits wear particle-induced osteolysis. However, the molecular mechanism through which icariin inhibits RANKL-induced osteoclastogenesis has not been fully understood. Read More

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December 2018

MicroRNA-153-3p enhances cell radiosensitivity by targeting BCL2 in human glioma.

Biol Res 2018 Dec 11;51(1):56. Epub 2018 Dec 11.

Department of Neurosurgery, Liaoning Cancer Hospital & Institute, No.44 Xiao Heyan Street, Shenyang, 110042, Liaoning, China.

Background: Glioma is the most prevalent malignant tumor in human central nervous systems. Recently, the development of resistance to radiotherapy in glioma patients markedly vitiates the therapy outcome. MiR-153-3p has been reported to be closely correlated with tumor progression, but its effect and molecular mechanism underlying radioresistance remains unclear in glioma. Read More

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December 2018

Musculoskeletal Ultrasound in Early Rheumatoid Arthritis - Correlations with Disease Activity Score.

Curr Health Sci J 2015 Jul-Sep;41(3):213-218. Epub 2015 Jan 29.

University of Medicine and Pharmacy of Craiova, Rheumatology Department.

Purpose: to assess synovial inflammation using musculoskeletal ultrasonography, in a cohort of patients with early rheumatoid arthritis, and establish the correlations with disease activity score.

Material And Methods: We enrolled 29 patients diagnosed with early RA, according to ACR-EULAR 2010 classification criteria, in Rheumatology Clinic, Emergency County Hospital Craiova, between September 2013-August 2014. We performed clinical evaluation, assessed laboratory tests and performed US for all the patients. Read More

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January 2015

Mid-calf skeletal muscle density and its associations with physical activity, bone health and incident 12-month falls in older adults: The Healthy Ageing Initiative.

Bone 2018 Dec 8. Epub 2018 Dec 8.

Department of Community Medicine and Rehabilitation, Geriatric Medicine, Umeå University, Umeå, Sweden.

Background: Lower skeletal muscle density, indicating greater infiltration of adipose tissue into muscles, is associated with higher fracture risk in older adults. We aimed to determine whether mid-calf muscle density is associated with falls risk and bone health in community-dwelling older adults.

Methods: 2214 community-dwelling men and women who participated in the Healthy Ageing Initiative (Sweden) study at age 70 were included in this analysis. Read More

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December 2018
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Genes known to escape X chromosome inactivation predict co-morbid chronic musculoskeletal pain and posttraumatic stress symptom development in women following trauma exposure.

Am J Med Genet B Neuropsychiatr Genet 2018 Dec 11. Epub 2018 Dec 11.

Institute for Trauma Recovery, University of North Carolina, Chapel Hill, North Carolina.

Co-morbid chronic musculoskeletal pain (CMSP) and posttraumatic stress symptoms (PTSS) are frequent sequelae of motor vehicle collision, are associated with greater disability than either outcome alone, and are more prevalent in women than men. In the current study we assessed for evidence that gene transcripts originating from the X chromosome contribute to sex differences in vulnerability to CMSP and PTSS after motor vehicle collision. Nested samples were drawn from a longitudinal study of African American individuals, and CMSP (0-10 numeric rating scale) and PTSS (impact of events scale, revised) outcomes were assessed 6 months following motor vehicle collision. Read More

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December 2018
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Therapeutic potential of nvp-bkm120 in human osteosarcomas cells.

J Cell Physiol 2018 Dec 7. Epub 2018 Dec 7.

Department of Biomedical Sciences, University of Bologna, Bologna, Italy.

Osteosarcoma (OS) is the most common pediatric malignant neoplasia of the skeletal system. It is characterized by a high degree of malignancy and a severe tendency to metastasize. In the past decade, many studies have provided evidence that the phosphoinositide 3-kinase (PI3K) signaling pathway is one of the most frequently altered pathways in human cancer, and has a critical role in driving tumor initiation and progression. Read More

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December 2018

Cellular and Chemical Gradients to Engineer the Meniscus-to-Bone Insertion.

Adv Healthc Mater 2018 Dec 10:e1800806. Epub 2018 Dec 10.

Meinig School of Biomedical Engineering, Cornell University, Ithaca, NY, 14850, USA.

Tissue-engineered menisci hold promise as an alternative to allograft procedures but require a means of robust fixation to the native bone. The insertion of the meniscus into bone is critical for meniscal function and inclusion of a soft tissue-to-bone interface in a tissue engineered implant can aid in the fixation process. The native insertion is characterized by gradients in composition, tissue architecture, and cellular phenotype, which are all difficult to replicate. Read More

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December 2018
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Retrograde fixation of the lesser trochanter in the adolescent: new surgical technique and clinical results of two cases.

Arch Orthop Trauma Surg 2018 Dec 10. Epub 2018 Dec 10.

Department of Orthopaedic Sports Medicine, Klinikum rechts der Isar, Technical University of Munich, Munich, Germany.

Introduction: Avulsions of the lesser femoral trochanter are rare injuries in the adolescent population. An acute avulsion causes severe functional impairment with compromised hip flexion. Recent literature reports the superiority of surgical treatment for apophyseal avulsion fractures of the pelvis in adolescents. Read More

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December 2018

The temporal relationship between cancer and adult onset anti-transcriptional intermediary factor 1 antibody-positive dermatomyositis.

Rheumatology (Oxford) 2018 Dec 7. Epub 2018 Dec 7.

Centre for Musculoskeletal Research, University of Manchester, Manchester, UK.

Objectives: To characterize the 10 year relationship between anti-transcriptional intermediary factor 1 antibody (anti-TIF1-Ab) positivity and cancer onset in a large UK-based adult DM cohort.

Methods: Data from anti-TIF1-Ab-positive/-negative adults with verified diagnoses of DM from the UK Myositis Network register were analysed. Each patient was followed up until they developed cancer. Read More

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December 2018
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Association between physical activity and scoliosis: a prospective cohort study.

Int J Epidemiol 2018 Dec 6. Epub 2018 Dec 6.

Musculoskeletal Research Unit, University of Bristol, Southmead Hospital, Bristol, UK.

Background: Little is understood about the causes of adolescent onset idiopathic scoliosis (AIS). No prospective studies assessing the association between physical activity and idiopathic adolescent scoliosis have been carried out. We aimed to carry out the first prospective population-based study of this association. Read More

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December 2018

Persistent upregulation of the β-tubulin tubb6, linked to muscle regeneration, is a source of microtubule disorganization in dystrophic muscle.

Hum Mol Genet 2018 Dec 6. Epub 2018 Dec 6.

Light Imaging Section, Office of Science and Technology, National Institute of Arthritis and Musculoskeletal and Skin Diseases (NIAMS), National Institutes of Health (NIH), Bethesda, MD, USA.

In healthy adult skeletal muscle fibers microtubules form a three-dimensional grid-like network. In the mdx mouse, a model of Duchenne muscular dystrophy (DMD), microtubules are mostly disordered, without periodicity. These microtubule defects have been linked to the mdx mouse pathology. Read More

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December 2018

Non-battle Emergency Department Utilization of the First Modular Army Field Hospital Prototype in Support of Operation INHERENT RESOLVE.

Mil Med 2018 Dec 7. Epub 2018 Dec 7.

San Antonio Military Medical Center, 3551 Roger Brooke Drive, Joint Base San Antonio, TX.

Introduction: The 2010-2011 withdrawal from Iraq included the closure of all fixed-facility military medical resources. Operation INHERENT RESOLVE, the United States-led counter-terrorism mission in Iraq and Syria, subsequently commenced in 2014. With increasing combat operations, the 28th Combat Support Hospital deployed to Iraq to support that mission as a limited footprint unit prototyped after the new modular Army Field Hospital. Read More

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December 2018

[Levels of physical activity and excess body weight in university students].

Rev Med Chil 2018 Aug;146(8):840-849

BHF Glasgow Cardiovascular Research Centre, Institute of Cardiovascular and Medical Sciences, University of Glasgow, Glasgow, United Kingdom.

Background: University students are considered a vulnerable group due to their adoption of unhealthy diets and lifestyles.

Aim: To determine the main risk factors associated with low level of physical activity and excess body weight in university students.

Material And Methods: This cross-sectional study included 358 university students from Talca, (53% female). Read More

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Musculoskeletal ultrasound as a biomarker of remission - results from a one-year prospective study in patients with rheumatoid arthritis.

Med Ultrason 2018 Dec;20(4):453-460

Medical University of Plovdiv, Medical Faculty, Department of Propedeutic of Internal Diseases; University Hospital "Kaspela'', Rheumatology Clinic.

Aims: To assess the role of musculoskeletal ultrasound (MSUS) as a biomarker of remission and to compare the rates of clinical and imaging remission in patients with rheumatoid arthritis (RA) on different types of treatment.

Material And Methods: One hundred and forty-one patients underwent physical and ultrasound examination at 5 visits (at baseline and after 1, 3, 6 and 12 months). Patients were divided into two groups according to the type of treatment, which involved synthetic (sDMARDs) and biologic (bDMARDs) disease-modifying antirheumatic drugs. Read More

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December 2018

The utility and validity of pain intensity rating scales for use in developing countries.

Pain Rep 2018 Sep-Oct;3(5):e672. Epub 2018 Aug 6.

Department of Rehabilitation Medicine, University of Washington, Seattle, WA, USA.

Introduction: Pain intensity is the domain most often assessed in pain research. Although the Numerical Rating Scale is recommended for use in western countries, the utility and validity of this scale, relative to others, has not been established in non-western developing countries, such as Nepal.

Objectives: Here, we sought to (1) identify which of 4 commonly used pain scales is most preferred by Nepalese, (2) compare error rates, (3) determine whether preference and error rates are influenced by age or education level, and (4) evaluate construct validity of each scale using factor analysis. Read More

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August 2018
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Costs and consequences of chronic pain due to musculoskeletal disorders from a health system perspective in Chile.

Pain Rep 2018 Sep-Oct;3(5):e656. Epub 2018 Sep 10.

Health Technology Assessment Unit, Center of Clinical Research, Faculty of Medicine, Pontificia Universidad Católica de Chile, Santiago, Chile.

Background: Chronic pain is a prevalent and distressing condition caused by an unceasing pain lasting more than 3 months or a pain that persists beyond the normal healing time. There is evidence of inadequate management partly explained by the unawareness regarding the magnitude of the problem.

Objectives: To estimate the annual expected costs and consequences of chronic pain caused by musculoskeletal diseases from the health system perspective in Chile. Read More

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September 2018

CLINICAL REASONING IN THE FACE OF UNCERTAINTY: CONSERVATIVE PHYSICAL THERAPY MANAGEMENT OF A TEENAGE ATHLETE DIAGNOSED WITH A PROXIMAL HUMERAL NON-OSSIFYING FIBROMA.

Int J Sports Phys Ther 2018 Dec;13(6):1049-1060

Ithaca College, Ithaca, NY, USA.

Background And Purpose: There have been few published studies regarding the treatment of patients with non-ossifying fibromas (NOFs), either conservatively or operatively. The purpose of this case report is to discuss the clinical presentation and conservative management of a teenage athlete diagnosed with a proximal humerus NOF.

Case Description: The subject was a 13-year-old male middle school student with a diagnosis of left shoulder pain over the prior year preventing him from participating in sports activities. Read More

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December 2018

COMPARISON OF NON-CONTACT AND CONTACT TIME-LOSS LOWER QUADRANT INJURY RATES IN MALE COLLEGIATE BASKETBALL PLAYERS: A PRELIMINARY REPORT.

Int J Sports Phys Ther 2018 Dec;13(6):963-972

Clackamas Community College, Oregon City, OR, USA.

Background: Male collegiate basketball (BB) players are at risk for musculoskeletal injury. The rate of time-loss injury in men's collegiate BB, for levels of National Collegiate Athletic Association (NCAA) competition, ranges from 2.8 to 4. Read More

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December 2018

Muscular imbalances and balance capability in dance.

J Occup Med Toxicol 2018 3;13:36. Epub 2018 Dec 3.

2Department Sports Medicine and Training Science, Christian-Albrechts-Universität Kiel, Institute of Sports Science, Olshausenstrasse 74, 24098 Kiel, Germany.

Objective: A high unilateral load to the musculoskeletal system is specific for formation dance. Due to the lack of data the aim of this study was the side-related (right - left) analysis of strength- and balance capability subject to injuries, gender and performance standards.

Methods:  = 51 dancers (m:  = 24, f: m = 27) of two performance levels participated in this cross-sectional study. Read More

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December 2018

Effect of Osteopathic Visceral Manipulation on Pain, Cervical Range of Motion, and Upper Trapezius Muscle Activity in Patients with Chronic Nonspecific Neck Pain and Functional Dyspepsia: A Randomized, Double-Blind, Placebo-Controlled Pilot Study.

Evid Based Complement Alternat Med 2018 11;2018:4929271. Epub 2018 Nov 11.

Postgraduate Program in Rehabilitation Sciences, Physical Therapy Departament, Universidade Nove de Julho, UNINOVE, Brazil.

Previous studies have reported that visceral disturbances can lead to increased musculoskeletal tension and pain in structures innervated from the corresponding spinal level through viscerosomatic reflexes. We designed a pilot randomised placebo-controlled study using placebo visceral manipulation as the control to evaluate the effect of osteopathic visceral manipulation (OVM) of the stomach and liver on pain, cervical mobility, and electromyographic activity of the upper trapezius (UT) muscle in individuals with nonspecific neck pain (NS-NP) and functional dyspepsia. Twenty-eight NS-NP patients were randomly assigned into two groups: treated with OVM (OVMG; = 14) and treated with placebo visceral manipulation (PVMG; = 14). Read More

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November 2018

Culture-Negative Periprosthetic Joint Infection: An Update on What to Expect.

JB JS Open Access 2018 Sep 12;3(3):e0060. Epub 2018 Jul 12.

Rothman Institute at Thomas Jefferson University, Philadelphia, Pennsylvania.

Background: Culture-negative periprosthetic joint infection (PJI) is a challenging condition to treat. The most appropriate management of culture-negative PJI is not known, and there is immense variability in the treatment outcome of this condition. The purpose of this study was to elucidate the characteristics, outcomes, and risk factors for failure of treatment of culture-negative PJI. Read More

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September 2018

S100A12 Serum Levels and PMN Counts Are Elevated in Childhood Systemic Vasculitides Especially Involving Proteinase 3 Specific Anti-neutrophil Cytoplasmic Antibodies.

Front Pediatr 2018 23;6:341. Epub 2018 Nov 23.

Department of Pediatric Rheumatology and Immunology, University Hospital Muenster, Muenster, Germany.

Chronic primary systemic vasculitidies (CPV) are a collection of rare diseases involving inflammation in blood vessels, often in multiple organs. CPV can affect adults and children and may be life- or organ-threatening. Treatments for adult CPV, although effective, have known severe potential toxicities; safety and efficacy of these drugs in pediatric patients is not fully understood. Read More

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November 2018
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Osteochondral tissue repair in osteoarthritic joints: clinical challenges and opportunities in tissue engineering.

Biodes Manuf 2018 28;1(2):101-114. Epub 2018 May 28.

1Institute of Orthopaedic and Musculoskeletal Science, Division of Surgery and Interventional Science, University College London, Royal National Orthopaedic Hospital, Stanmore, HA7 4LP UK.

Osteoarthritis (OA), identified as one of the priorities for the Bone and Joint Decade, is one of the most prevalent joint diseases, which causes pain and disability of joints in the adult population. Secondary OA usually stems from repetitive overloading to the osteochondral (OC) unit, which could result in cartilage damage and changes in the subchondral bone, leading to mechanical instability of the joint and loss of joint function. Tissue engineering approaches have emerged for the repair of cartilage defects and damages to the subchondral bone in the early stages of OA and have shown potential in restoring the joint's function. Read More

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Influence of ergonomic layout of musician chairs on posture and seat pressure in musicians of different playing levels.

PLoS One 2018 11;13(12):e0208758. Epub 2018 Dec 11.

Institute of Occupational Medicine, Social Medicine and Environmental Medicine, Goethe-University Frankfurt am Main, Frankfurt am Main, Germany.

Introduction: Musicians often perform in forced postures over a long period of time, which in the worst case may lead to playing-related musculoskeletal disorders. In this context, the ergonomics of the musician's chair (construction and surface quality) can be an influencing factor, with impact on the seating position of the upper body and the pressure distribution of the bottom. Therefore, the relationship between different musician chairs and musicians of different playing levels (professional, amateur or student) was analyzed in order to gain useful insights whether playing experience, playing level, playing style (symmetrical or asymmetrical) or gender have an impact. Read More

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December 2018

Exploring the link between metabolic syndrome and risk of dysmobility syndrome in elderly population.

PLoS One 2018 11;13(12):e0207608. Epub 2018 Dec 11.

Division of Family Medicine, Department of Family and Community Medicine, Tri-Service General Hospital, and School of Medicine, National Defense Medical Center, Taipei, Taiwan, Republic of China.

Dysmobility syndrome (DMS) was considered as a comprehensive approach to evaluate the condition of musculoskeletal system and adverse health problems in older population. The objective of our study was to examine the association between metabolic syndrome (MetS) and DMS in a U.S. Read More

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December 2018

Cervical disc degeneration and neck pain.

J Pain Res 2018 14;11:2853-2857. Epub 2018 Nov 14.

Interventional Spine and Musculoskeletal Care, Virginia iSpine Physicians, PC Virginia Spine Research Institute, Inc Richmond, VA, USA.

Cervical intervertebral disc has long been considered a common source of neck pain. However, the pain caused by the disc itself has not been clearly defined so far, and its diagnosis and treatment has always been controversial. Degenerative cervical disc has a rich supply of nerve fibers, is prone to inflammatory reactions, and is susceptible to pain that can be provoked by disc stimulation or distention, and can be eliminated by block. Read More

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November 2018

A case of a patient with severe epidermolysis bullosa surviving to adulthood.

Int J Gen Med 2018 15;11:413-421. Epub 2018 Nov 15.

Department of Skin and Venereal Diseases, I.M. Sechenov First Moscow State Medical University, Moscow, Russia,

Purpose: The aim of this study was to evaluate the progression of a case of a patient with epidermolysis bullosa (EB) since early age who survived to adulthood, presenting with recurrent skin blisters and disfiguring scars and disabling musculoskeletal deformities.

Background: EB is a rare group of inherited diseases that affect the skin fragility causing it to blister in response to even minor trauma. Established novel treatments are limited in the literature due to its rarity, and more research is needed to set a global management approach. Read More

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November 2018

Determining functional activity profiles in patients with upper extremity disorders: is there effect modification by hand-grip strength?

Clin Interv Aging 2018 15;13:2351-2358. Epub 2018 Nov 15.

Institute of Health Sciences, Gyeongsang National University College of Medicine, Jinju, Republic of Korea,

Purpose: The purposes of this study were to investigate the effect of hand-grip strength (HGS) on the Disabilities of the Arm, Shoulder, and Hand (DASH) score in women with upper extremity musculoskeletal disorders (UEMDs) living in rural communities and examine whether upper extremity diseases affected upper extremity functional activity in each group (normal/low HGS) and whether grip strength (GS) was an effect modifier in upper extremity functional activity.

Methods: A total of 239 women older than 60 years who had completed a medical workup for epicondylitis, rotator cuff tears, and/or hand osteoarthritis were included in the final study. Functional activity was assessed by DASH, and muscle strength was measured by GS. Read More

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November 2018
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Automated noninvasive detection of idiopathic scoliosis in children and adolescents: A principle validation study.

Sci Rep 2018 Dec 7;8(1):17714. Epub 2018 Dec 7.

Division of Systems Science and Informatics, Hokkaido University Graduate School of Information Science and Technology, N14W9, Sapporo, Hokkaido, 060-0814, Japan.

Idiopathic scoliosis is the most common pediatric musculoskeletal disorder that causes a three-dimensional deformity of the spine. Early detection of this progressive aliment is essential. The aim of this study is to determine outcomes using a newly developed automated asymmetry-evaluation system for the surface of the human back using a three-dimensional depth sensor. Read More

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December 2018

A new corrosion-inhibiting strategy for biodegradable magnesium: reduced nicotinamide adenine dinucleotide (NADH).

Sci Rep 2018 Dec 10;8(1):17743. Epub 2018 Dec 10.

Center for Biomaterials, Korea Institute of Science and Technology (KIST), Seoul, 02792, Republic of Korea.

Utilization of biodegradable metals in biomedical fields is emerging because it avoids high-risk and uneconomic secondary surgeries for removing implantable devices. Mg and its alloys are considered optimum materials for biodegradable implantable devices because of their high biocompatibility; however, their excessive and uncontrollable biodegradation is a difficult challenge to overcome. Here, we present a novel method of inhibiting Mg biodegradation by utilizing reduced nicotinamide adenine dinucleotide (NADH), an endogenous cofactor present in all living cells. Read More

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December 2018

Can Dynamic Ultrasonography of the Hip Reliably Assess Anterior Femoral Head Translation?

Clin Orthop Relat Res 2018 Nov 7. Epub 2018 Nov 7.

P. A. d'Hemecourt, D. Sugimoto, M. McKee-Proctor, R. L. Zwicker, S. S. Jackson, A. Stracciolini, Division of Sports Medicine, Department of Orthopaedics, Boston Children's Hospital, Boston, MA, USA P. A. d'Hemecourt, S. S. Jackson, E. N. Novais, Y.-J. Kim, M. B. Millis, A. Stracciolini, Department of Orthopaedics, Boston Children's Hospital, Harvard Medical School, Boston, MA, USA A. Stracciolini, Department of Medicine, Division of Emergency Medicine, Boston Children's Hospital, Boston, MA, USA P. A. d'Hemecourt, D. Sugimoto, S. S. Jackson, E. N. Novais, Y.-J. Kim, M. B. Millis, A. Stracciolini, Harvard Medical School, Boston, MA, USA P. A. d'Hemecourt, D. Sugimoto, S. S. Jackson, A. Stracciolini, The Micheli Center for Sports Injury Prevention, Waltham, MA, USA.

Background: Hip microinstability has gained attention recently as a potential cause of hip pain. Currently there is a lack of evidence-based objective diagnostic criteria surrounding this diagnosis. Previous studies have shown translation of the femoral head during extreme hip positions. Read More

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November 2018
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A therapeutic exercise program improves pain and physical dimension of health-related quality of life in young adults. A Randomized Controlled Trial.

Am J Phys Med Rehabil 2018 Dec 6. Epub 2018 Dec 6.

Member of the Psychosocial Intervention and Functional Rehabilitation Research Group, Department of Biomedical Sciences, Medicine and Physiotherapy, Faculty of Physiotherapy, University of A Coruña, A Coruña Campus, 15071 A Coruña, Spain.

Objective: The aim of this study was to evaluate the effects of an exercise therapy program on pain and physical dimension of health-related quality of life for young adults with musculoskeletal pain.

Design: Randomized controlled single-blind trial. Fifty-seven subjects (58% women) were randomly assigned to experimental (n=28; 21. Read More

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December 2018
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Low back pain among nursing professionals in Jeddah, Saudi Arabia: Prevalence and risk factors.

J Back Musculoskelet Rehabil 2018 Nov 26. Epub 2018 Nov 26.

Background: Lower back pain (LBP) is often work-related and is commonly observed among nurses. LBP occurs below the 12th rib and above the gluteal fold. In nurses, back disorders are mainly associated with heavy physical activity, such as lifting and moving patients. Read More

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November 2018

Does ergonomics training have an effect on body posture during computer usage?

J Back Musculoskelet Rehabil 2018 Nov 30. Epub 2018 Nov 30.

Background: Computer users are at risk in terms of musculoskeletal disorders. It is known that ergonomics training prevents short-term injuries to the musculoskeletal system, but its long-term effect is unknown.

Objective: The aim of our study was to investigate the effect of receiving ergonomics training in undergraduate instruction on posture during computer usage. Read More

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November 2018

Genetics of rheumatoid arthritis: 2018 status.

Ann Rheum Dis 2018 Dec 8. Epub 2018 Dec 8.

Laboratory for Autoimmune Diseases, RIKEN Center for Integrative Medical Sciences, Yokohama, Japan

Study of the genetics of rheumatoid arthritis (RA) began about four decades ago with the discovery of Since the beginning of this century, a number of non-HLA risk loci have been identified through genome-wide association studies (GWAS). We now know that over 100 loci are associated with RA risk. Because genetic information implies a clear causal relationship to the disease, research into the pathogenesis of RA should be promoted. Read More

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December 2018