Search Our Scientific Publications & Authors

Radiol Clin North Am 2022 Mar 31;60(2):283-299. Epub 2022 Jan 31.

Department of Radiology, Sylvester Comprehensive Cancer Center, University of Miami Miller School of Medicine/Jackson Memorial Hospital, 1611 NorthWest 12th Avenue, JMH WW 279, Miami, FL 33136, USA. Electronic address:

Imaging in soft tissue sarcomas (STS) plays a key role in diagnosis, surgical planning, and assessment of treatment response, and surveillance. In this review, we discuss the imaging features-with an emphasis on MR imaging-of nonvisceral STS, highlighting representative tumors from the various WHO subtypes. We focus on imaging findings that may aid the radiologist in categorizing tumor subtype and grade, and that affect disease staging. Read More

J Laryngol Otol 2022 Apr 25;136(4):297-303. Epub 2021 Nov 25.

Head and Neck Surgical Oncology, Peter MacCallum Cancer Centre, Melbourne, Australia.

Background: Lateral temporal bone resections are used in the management of locally advanced peri-auricular cutaneous squamous cell carcinomas, but there is still conflicting evidence regarding the staging, surgical and adjuvant treatment decisions.

Methods: A retrospective analysis was performed on all patients who underwent lateral temporal bone resection for cutaneous squamous cell carcinoma between January 2015 and December 2019 at a dedicated tertiary oncology referral centre.

Results: Twenty-nine patients were included, with a median age of 77 years. Read More

Lin Chung Er Bi Yan Hou Tou Jing Wai Ke Za Zhi 2021 Aug;35(8):740-745

Department of Otolaryngology Head and Neck Surgery，Xiangya Hospital of Central South University，Hunan Province Key Laboratory of Otolaryngology Critical Diseases，Changsha，410008，China.

To investigate the clinical features of neuroendocrine carcinoma of nose and skull base and the efficacy and prognosis of endoscopic resection. The clinical data of 7 patients with neuroendocrine carcinoma of nose and skull base treated by endoscopic surgery were retrospectively analyzed. According to the international TNM staging, there were 1 case of stage Ⅰ, 1 case of stage Ⅱ, 1 case of stage Ⅲ, 1 case of stage ⅣA and 3 cases of stage ⅣB. Read More

Clin Imaging 2021 Nov 16;79:64-84. Epub 2021 Apr 16.

Department of Radiology, Cardiothoracic Division, University Hospitals Cleveland Medical Center, Cleveland, OH, USA. Electronic address:

Extrapleural space (EPS) is a potential space between the outer layer of the parietal pleura and the inner layer of the chest wall and the diaphragm. Many different pathologies including chronic inflammatory conditions, infections, trauma, neoplastic disease (both benign and malignant) as well as many infiltrative disorders can involve the EPS. It is one of the frequently overlooked entity on imaging due to relative lack of understanding of the anatomy and the imaging appearances of the diseases localized to this space. Read More

AJR Am J Roentgenol 2021 11 14;217(5):1038-1052. Epub 2021 Apr 14.

Mayo Clinic College of Medicine, Rochester, MN.

Staging of primary musculoskeletal bone and soft-tissue tumors is most commonly performed using the AJCC and the Enneking or Musculoskeletal Tumor Society (MSTS) staging systems. Radiologic imaging is integral in achieving adequate musculoskeletal neoplastic staging by defining lesion extent and identifying regional lymph node involvement and distant metastatic disease. Additional important features in surgical planning, though not distinct components of the staging systems, include cortical involvement, joint invasion, and neurovascular encasement; these features are optimally evaluated by MRI. Read More

Semin Ultrasound CT MR 2021 Apr 29;42(2):194-200. Epub 2020 Aug 29.

Department of Musculoskeletal Imaging, The University of Texas MD Anderson Cancer Center, Houston, TX. Electronic address:

Imaging evaluation of soft tissue masses is essential for diagnosis, preoperative staging, and post-treatment follow-up. Magnetic resonance imaging plays the major role because of its superior resolution that helps in better tissue characterization, and its multiplanar imaging capability in evaluation of soft tissue masses. Additional imaging techniques, such as radiographs, computed tomography, positron-emission tomography-CT, radionuclide scintigraphy and ultrasonography, also play vital roles by providing additional information required in management of soft tissue masses. Read More

Otolaryngol Head Neck Surg 2021 07 8;165(1):59-68. Epub 2020 Dec 8.

Indiana University School of Medicine, Indianapolis, Indiana, USA.

Objective: To determine the role of skeletal muscle index (SMI) in the assessment of frailty and determination of discharge to post-acute care facilities (PACF) after head and neck cancer free flap reconstruction (HNCFFR).

Study Design: Retrospective cohort.

Setting: Single-institution, academic tertiary referral center. Read More

J Craniomaxillofac Surg 2020 Dec 1;48(12):1158-1163. Epub 2020 Nov 1.

University of Heidelberg, Department of Oral and Cranio-Maxillofacial Surgery (Head of Department: Prof. Dr. Dr. J. Hoffmann), Im Neuenheimer Feld 400, D-69120 Heidelberg, Germany.

Introduction: Oral squamous cell carcinomas exhibit distinct patterns of disease progression, depending on their localisation. This study aimed to evaluate clinicopathological data in patients with tumors of the mandibular alveolar process, to facilitate risk assessment and therapy planning.

Materials And Methods: A retrospective cohort study was designed including patients with squamous cell carcinoma of the mandibular gingiva. Read More

Gynecol Oncol 2021 01 24;160(1):40-44. Epub 2020 Oct 24.

Department of Obstetrics and Gynecology, Division of Gynecologic Surgery, Mayo Clinic, Rochester, MN 55905, USA. Electronic address:

Objective: To compare baseline body composition measures (BCM), including sarcopenia, between patients with advanced epithelial ovarian cancer (EOC) undergoing primary cytoreductive surgery (PCS) versus neoadjuvant chemotherapy/interval cytoreductive surgery (NACT/ICS) and evaluate changes in BCM pre-NACT versus pre-ICS.

Methods: Patients with stage IIIC/IV EOC who underwent PCS or NACT with curative intent between 1/1/2012 and 7/31/2016 were included. Computed tomography scans were evaluated via a semi-automated program to determine BCM. Read More

Eur Spine J 2020 12 20;29(12):3229-3236. Epub 2020 Jul 20.

IRCCS Istituto Ortopedico Rizzoli, Bologna, Italy.

Introduction: Radiotherapy (RT) is frequently applied as an adjuvant therapy during spinal tumors treatment. Metallic implants can interfere with RT planning and execution, as it is known that metallic implants produce a backscattering effect that can limit RT accuracy and their presence can be associated with unwanted dose increase. PEEK/carbon fiber implants are designed to reduce these problems but their application in the cervical spine is limited, due to the reduced number and types of implants, the screw dimensions and the absence of lateral mass screws. Read More

Head Neck 2020 08 2;42(8):2002-2012. Epub 2020 Mar 2.

Department of Otorhinolaryngology, Head and Neck Surgery, University Hospital Zurich, Zurich, Switzerland.

Background: Knowledge of medial orbital wall (MOW) and anterior skull base (ASB) infiltration is of uttermost importance for staging and therapy planning of advanced sinonasal tumors.

Methods: We assessed the diagnostic performance of preoperative computed tomography (CT) and magnetic resonance imaging (MRI) for MOW and ASB infiltration compared to intraoperative exploration.

Results: Both CT and MRI yielded higher diagnostic accuracy for MOW infiltration (Reader 1: 83. Read More

Clin Oral Investig 2020 Sep 18;24(9):3077-3083. Epub 2020 Jan 18.

Department of Oral and Maxillofacial Surgery, Klinikum rechts der Isar, Technische Universität München, Ismaninger Str. 22, D-81675, Munich, Germany.

Objectives: Mandibular reconstruction after segmental mandibulectomy can be challenging without virtual surgical planning and osteotomy guides. The purpose of this study was to analyze anatomic parameters to facilitate the evaluation of ideal fibula wedge osteotomies to reconstruct the neomandibula in a simple and cost-effective manner without the need for preoperative virtual planning.

Materials And Methods: Computed tomography scans were acquired from randomly selected patients, and all images were obtained from routine clinical diagnostics, e. Read More

J Nucl Med Technol 2020 Mar 6;48(1):9-16. Epub 2019 Dec 6.

Department of Radiology, University of Alabama at Birmingham, Birmingham, Alabama

The skeleton is the third most common site for metastasis overall, after the lungs and liver. Accurate diagnosis of osseous metastasis is critical for initial staging, treatment planning, restaging, treatment monitoring, and survival prediction. Currently, Tc-methylene diphosphonate whole-body scanning is the cornerstone of imaging to detect osseous metastasis. Read More

Brachytherapy 2020 Mar - Apr;19(2):264-274. Epub 2019 Nov 29.

Interventional Radiotherapy Ward, Department of Radiation Oncology, Golestan Hospital, Ahvaz Jundishapur University of Medical Sciences, Ahvaz, Iran. Electronic address:

Purpose: To dosimetrically compare interstitial brachytherapy (MIBT) vs. EBRT (3DCRT and high-energy electron beams) for deep-seated tumor bed boosts (depth ≥4 cm) in early-stage breast cancer.

Methods And Materials: Planning CTs of fifteen left-side breast cancer patients previously treated with MIBT boost chosen for this study. Read More

Cancer Immunol Immunother 2019 Dec 12;68(12):2067-2080. Epub 2019 Nov 12.

Department of Immunology, School of Basic Medical Sciences, Fudan University, Building West 13, No. 138 Yixueyuan Road, Shanghai, 200032, China.

Purpose: Tumor-associated macrophages (TAMs) exist as heterogeneous subsets and have dichotomous roles in cancer-immune evasion. This study aims to assess the clinical effects of Galectin-9 tumor-associated macrophages (Gal-9TAMs) in muscle-invasive bladder cancer (MIBC).

Experimental Design: We identified Gal-9TAMs by immunohistochemistry (IHC) analysis of a tumor microarray (TMA) (n = 141) from the Zhongshan Hospital and by flow cytometric analysis of tumor specimens (n = 20) from the Shanghai Cancer Center. Read More

J Reconstr Microsurg 2019 Jul 18;35(6):425-429. Epub 2019 Jan 18.

Division of Plastic Surgery, Department of Surgery, Mayo Clinic, Rochester, Minnesota.

Background:  The purpose of this study is to describe our experience and outcomes in oncoplastic pelvic reconstruction for patients who underwent either vertical rectus abdominis musculocutaneous (VRAM) or omental flap following abdominoperineal resection (APR) at a single tertiary care institution.

Methods:  All patients who underwent pelvic reconstruction following APR with either VRAM or omental flaps from January 1992 to January 2017 were retrospectively reviewed. Patient demographics and relevant comorbidities including chemotherapy and radiation therapy data were collected and analyzed. Read More

Cancer 2018 10 15;124(19):3868-3875. Epub 2018 Oct 15.

University of Toronto Musculoskeletal Oncology Unit, Mount Sinai Hospital, Toronto, Ontario, Canada.

Background: Soft-tissue sarcomas (STSs) are a heterogeneous group of malignant tumors that can be difficult to treat. This is particularly true after incomplete or unplanned excisions and especially for patients with American Joint Committee on Cancer stage III tumors, who are at high risk for relapse. Numerous studies have shown that an inadequate sarcoma excision is associated with a worse prognosis. Read More

Magn Reson Imaging Clin N Am 2018 Nov;26(4):571-579

Radiology Department, Clínica de Diagnóstico por Imagem (CDPI)/DASA, Avenida das Américas, 4666, sala 301B, Centro Médico BarraShopping, CDPI, Barra da Tijuca, Rio de Janeiro, RJ CEP: 22640-102, Brazil; Radiology Department, Alta Excelência Diagnóstica/DASA, Avenida das Américas, 4666, sala 301B, Centro Médico BarraShopping, CDPI, Barra da Tijuca, Rio de Janeiro, RJ CEP: 22640-102, Brazil; Radiology Department, Universidade Federal Fluminense, Av Marques do Paraná, 303, Centro, Niterói, RJ CEP: 24020-071, Brazil.

Neoplastic musculoskeletal lesions are heterogeneous tumors with variable outcomes that require a precise diagnosis and delivery of optimal, specific treatment. Advanced MR imaging techniques can help differentiate and characterize musculoskeletal soft tissue tumors and are the method of choice for detection, evaluation, local staging, and surgical planning. MR imaging-ultrasound fusion is the process of combining relevant information from 2 methods into a single image that is more informative than the images obtained separately. Read More

Zhongguo Xiu Fu Chong Jian Wai Ke Za Zhi 2017 09;31(9):1069-1072

Department of Bone Tumor Surgery, Orthopedics Center, the First Affiliated Hospital of Xinjiang Medical University, Urumchi Xinjiang, 830054,

Objective: To discuss the effect of three-dimensional (3D) printing individualized model and guide plate in bone tumor surgery.

Methods: Between October 2015 and December 2016, 3D printing individualized model and guide plate for making preoperative surgical planning and intraoperative treatment were used in 5 patients of bone tumor. All the patients were male, with a median age of 32 years (range, 9-58 years). Read More

Int J Colorectal Dis 2018 Jul 17;33(7):901-909. Epub 2018 May 17.

Clinic of Radiology, Ludwig Maximilians University of Munich, Marchionini Str. 15, 81377, Munich, Germany.

Purpose: The prediction of an infiltration of the mesorectal fascia (MRF) and malignant lymph nodes is essential for treatment planning and prognosis of patients with rectal cancer. The aim of this study was to assess the additional diagnostic value of dynamic contrast-enhanced magnetic resonance imaging (DCE-MRI) for the detection of a malignant involvement of the MRF and of mesorectal lymph nodes in patients with locally advanced rectal cancer.

Methods: In this prospective study, 22 patients with locally advanced rectal cancer were examined with 1. Read More

BMJ Case Rep 2018 May 7;2018. Epub 2018 May 7.

Department of Surgical Oncology, Batra Hospital and Medical Research Centre, New Delhi, Delhi, India.

J Am Coll Radiol 2018 May;15(5S):S189-S197

Panel Chair, University of Kentucky, Lexington, Kentucky.

Imaging is an integral component of the evaluation of patients with a suspected soft-tissue mass. Imaging can not only confirm the presence of a mass but can provide essential information necessary for diagnosis, local staging, and biopsy planning. Although the objectives of the evaluation have not changed, the choices available for imaging of musculoskeletal masses have evolved dramatically in recent years. Read More

PLoS One 2018 20;13(4):e0196059. Epub 2018 Apr 20.

Department of Oral and Maxillofacial Surgery, University Medical Centre Groningen, Groningen, The Netherlands.

Background: MRI is the optimal method for sensitive detection of tumour tissue and pre-operative staging in oral cancer. When jawbone resections are necessary, the current standard of care for oral tumour surgery in our hospital is 3D virtual planning from CT data. 3D printed jawbone cutting guides are designed from the CT data. Read More

Zhongguo Gu Shang 2017 Sep;30(9):857-860

Department of Orthopaedics, Gansu Province People's Hospital, Lanzhou 730000, Gansu, China;

Objective: To investigate the clincial effects and feasibility of anterior thoracoscopically assisted surgery (TAS) with posterior one-stage total en block spondylectomy(TES) for thoracic spinal tumour.

Methods: From October 2014 to January 2016, 4 patients with thoracic spinal tumour were treated by anterior thoracoscopically assisted surgery with posterior one-stage total en block spondylectomy. There were 2 males and 2 females, aged 16, 35, 46, 60 years. Read More

J Mater Sci Mater Med 2018 Feb 2;29(3):23. Epub 2018 Feb 2.

Poznan University of Technology Chair of Management and Production Engineering, Poznań, Poland.

The aim of the study was to compare two types of mandible reconstructive operations with scapula and fibula free flaps: procedures with 3-D models from thermoplastic materials and conventional planning surgeries. 8 patients were treated due to an advanced oral cavity squamous cell carcinoma. In four patients with a mandibular defect, a physical 3-D model consisting of the reconstructed and unaffected sites was prepared for a reconstruction protocol. Read More

Sci Rep 2017 10 10;7(1):12885. Epub 2017 Oct 10.

Division of Hematology/Oncology, Department of Medicine, Kameda Medical Center, Kamogawa, Japan.

Multiple myeloma (MM) is a clonal plasma cell disorder originating in bone marrow. Whole body low-dose multidetector CT (MDCT) can depict bone marrow infiltration by myeloma cells into the adipose-rich fatty marrow of the appendicular skeleton. However, automated and objective volume measurement of bone marrow infiltration has not been established, and its clinical relevance remains unclear. Read More

BMC Med Imaging 2017 07 11;17(1):41. Epub 2017 Jul 11.

Department of Radiology and Nuclear Medicine, Cantonal Hospital, Spitalstrasse 13, 6000, Lucerne, Switzerland.

Background: Accurate lymph node staging is essential for adequate prognostication and therapy planning in patients with non-small cell lung cancer (NSCLC). FDG-PET/CT is a sensitive tool for the detection of metastases, including non-palpable supraclavicular lymph node (SCLN) metastases. Histological proof of metastatic spread and mutation analysis is crucial for optimal staging and therapy. Read More

Eur J Surg Oncol 2017 Aug 7;43(8):1385-1392. Epub 2017 Jun 7.

Department of Plastic Surgery, and Breast Surgery Unit, Comprehensive Cancer Center, Helsinki University Hospital, University of Helsinki, Helsinki, Finland.

Breast lymphomas comprise a rare group of malignant breast tumors. Among these, a new entity has emerged as a potentially under-diagnosed disease. Breast implant-associated anaplastic large cell lymphoma (BI-ALCL) most often manifests as a late periprosthetic effusion between 1 and 10 years after the implantation of silicone or saline-filled breast prostheses. Read More

Otolaryngol Clin North Am 2017 Apr;50(2):221-244

Department of Pathology, Mount Sinai Beth Israel, Icahn School of Medicine at Mount Sinai, First Avenue at 16th Street, New York, NY 10003, USA.

A wide variety of tumors present in the sinonasal and ventral skull base. Patients often have nonspecific symptoms initially and present with advanced tumors, affecting the orbit and other adjacent structures. Evaluation of these malignancies with modern imaging techniques can define tumor invasion, but biopsy is often required to establish a diagnosis because most have a nonspecific appearance. Read More

Clin Nucl Med 2017 Mar;42(3):191-192

From the *Unidad PET/TC, CETIR-ERESA, C/J Anselm Clave, Esplugues, Barcelona; and †Servicio Oncología, Hospital Sant Pau i Santa Tecla, Tarragona, Spain.

In hormone receptor-positive locally advanced breast cancer, endocrine therapy becomes an integral part of the therapeutic strategy. There are now significant numbers of available hormonal directed compounds, including selective aromatase and mTOR inhibitors, which allow an important therapeutic advance in these patients. Sequential F-FDG PET/CT studies provided essential information regarding response to different treatments, including targeted therapies, and adverse therapeutic effects that helped to better define the right moment to implement each therapeutic approach. Read More