76,800 results match your criteria Musculoskeletal Biopsy Percutaneous Needle Technique
PLoS One 2018 14;13(12):e0207837. Epub 2018 Dec 14.
Department of Occupational Health, Centro Hospitalar Universitário São João, Porto, Portugal.
Introduction: Healthcare workers account for 10% of the EU's total workforce, with a significant proportion of those employed in hospitals. Musculoskeletal injuries are the predominant group of injuries in healthcare professionals due to the physical demands of their work, such as the mobilization and positioning of the dependent patients. The management of this type of problem should take into account direct and indirect costs, such as periods of incapacity for work due to illness, hiring and training of new employees during periods of absence, reduced levels of productivity and the effects on production and quality of work. Read More
G Ital Med Lav Ergon 2018 Dec;40(4):248-256
Physical Medicine and Rehabilitation Unit, IRCCS Policlinico San Matteo Foundation, Pavia, Italy; University of Pavia, Italy.
Objectives: Systemic sclerosis is a multisystem autoimmune disease that causes chronic widespread obliterative vasculopathy of the small arteries associated with various degrees of tissue fibrosis. The prognosis of the disease depends largely on the visceral involvement; however musculoskeletal involvement is an important factor to functional disability. Suffering from a chronic auto-immune disease, such as Systemic Sclerosis, compromises the quality of life and the work ability. Read More
G Ital Med Lav Ergon 2018 Dec;40(4):203-207
Dipartimento di Sanità Pubblica, Medicina Sperimentale e Forense, Sezione di Medicina del Lavoro, Università degli Studi di Pavia and Unità Operativa di Medicina del Lavoro, Istituti Clinici Scientifici Maugeri IRCCS, Pavia.
Objectives: Musculo-skeletal disorders (MSD) are a large group of locomotor system pathologies with multifactorial etiology. Healthcare professionals are often exposed to biomechanical overload of the spine and upper limb, for example during patient handling, and represent a working population at risk.
Methods: In order to acquire further knowledge on this subject, we conducted a cross-sectional study (year 2016) among healthcare workers (excluding physicians) of the Sondrio Hospital (Italy), investigating the correlations between manual handling, MDS and job fitness. Read More
J Pathol 2018 Dec 13. Epub 2018 Dec 13.
Gerhard-Domagk-Institute of Pathology, University Hospital Münster, Münster, Germany.
Non-ossifying fibroma, which occasionally results in pathologic fracture, is considered the most common benign and self-limiting lesion of the growing skeleton. By DNA sequencing we have identified hotspot KRAS, FGFR1 and NF1 mutations in 48 of 59 patients (81.4%) with NOF, at allele frequencies ranging from 0. Read More
Anat Rec (Hoboken) 2018 Dec 13. Epub 2018 Dec 13.
Department of Anatomy and Neurobiology, Northeast Ohio Medical University, Rootstown, OH, 44272, USA.
Since their arrival approximately 200 years ago, the house mice (Mus musculus) on Gough Island (GI) rapidly increased in size to become the largest wild house mice on record. Along with this extreme increase in body size, GI mice adopted a predatory diet, consuming significant quantities of seabird chicks and eggs. We studied this natural experiment to determine how evolution of extreme size and a novel diet impacted masticatory apparatus performance and functional morphology in these mice. Read More
Am J Med Genet A 2018 Dec 12:e40530. Epub 2018 Dec 12.
Laboratoire de Génétique Médicale, Faculté de Médecine, Université de Strasbourg, Strasbourg cedex, France.
Anorectal anomalies (ARA) are common congenital anomalies. The etiology of ARA is unclear and its pathogenesis is controversial. Cases with ARA often have other non-ARA-associated congenital anomalies. Read More
Am J Ind Med 2019 Jan 12;62(1):3-13. Epub 2018 Dec 12.
School of Public Health, University of Alberta, Edmonton, Alberta, Canada.
Background: Emergency responders have jobs with physical demands that put them at risk of musculoskeletal injuries.
Objectives: This paper systematically reviews existing literature examining the relationship between fitness and occupational injury in this group.
Methods: Comprehensive electronic searches were conducted using key words relating to musculoskeletal injury, fitness, and emergency responders. Read More
J Ultrasound Med 2018 Dec 12. Epub 2018 Dec 12.
Research Service, Washington, DC, USA.
Objectives: Assessing aging muscle through estimates of muscle heterogeneity may overcome some of the limitations of grayscale analyses. The objectives of this study included determining statistical model parameters that characterize muscle echogenicity and are associated with strength in younger and older participants.
Methods: Thirty-three community-dwelling participants were assigned to younger and older groups. Read More
Intern Med J 2018 Dec 11. Epub 2018 Dec 11.
Sydney School of Public Health, University of Sydney, Sydney, NSW, Australia.
The Australia and New Zealand Musculoskeletal (ANZMUSC) Clinical Trials Network was formed to build capacity and infrastructure for high quality musculoskeletal clinical trials in our region. The purpose of this paper is to describe the steps taken in its formation to help others interested in establishing similar networks. In particular we describe the steps taken to form the collaboration and our progress in achieving our vision and mission. Read More
Mol Genet Genomic Med 2018 Dec 8. Epub 2018 Dec 8.
Department of Spine (Thoracic and Vertebra), The Second Affiliated Hospital of Inner Mongolia University, Hohhot, China.
Background: Lumbar disk disease (LDD) is a common musculoskeletal disorder. Several predisposing genetic and environmental risk factors have been established for symptomatic LDD.
Methods: We conducted a case-control association study to investigate the role of the COL11A2 gene in LDD. Read More
FASEB J 2018 Dec 14:fj201800695RR. Epub 2018 Dec 14.
Department of Otolaryngology, School of Medicine, Ajou University, Suwon, South Korea.
The use of nonthermal atmospheric plasma (NTP) in the biomedical field has recently expanded into cell death induction in cancer, infection prevention, inflammation treatment, and wound-healing enhancement. NTP has been demonstrated to enhance skin and muscle regeneration, but its effects on tissue regeneration, following deep tissue or muscle damage, remains underinvestigated. In this study, we determined the effects of NTP on muscle differentiation and the mechanisms of NTP's contribution to differentiation and regeneration. Read More
Paediatr Drugs 2018 Dec 13. Epub 2018 Dec 13.
Division of Rheumatology, Children's Mercy Kansas City, 2401 Gillham Road, Kansas City, MO, 64108, USA.
Background: Arthropathy of Down syndrome (DA) is largely under-recognized, with an average 2-year delay in diagnosis. Most patients present with polyarthritis, and treatment has historically been challenging.
Objectives: Our objective was to investigate the clinical features and treatment of DA in the largest cohort reported to date. Read More
J Spine Surg 2018 Sep;4(3):583-587
The Robert Jones and Agnes Hunt Orthopaedic Hospital NHS Foundation, Oswestry, Shropshire, UK.
Background: The aim of this study was to investigate whether massive lumbar disc herniations (LDH) can be managed safely with non-operative treatment. Whilst most LDH are treated successfully with analgesia and physiotherapy, there is little literature regarding the treatment of massive LDH. Their impressive size raises the suspicion that they may cause cauda equina syndrome and are therefore often treated surgically. Read More
Obere Extrem 2018 28;13(4):279-285. Epub 2018 Jun 28.
2Center for Musculoskeletal Surgery, Campus Virchow, Charité-Universitaetsmedizin, Berlin, Germany.
Background: Acute acromioclavicular (AC) dislocation is classified according to Rockwood (RW). Although of clinical relevance, dynamic horizontal translation (DHT) is not listed in this classification or in frequently used clinical evaluation tools. The aim of this study was (a) to evaluate vertical and horizontal AC joint instabilities and assess their combined occurrence and clinical appearance in a consecutive group of patients, as well as (b) to develop a new classification of acute AC joint dislocation. Read More
Spine J 2018 Nov;18(11):2167-2168
Department of Orthopaedic Surgery, The University of Tokyo, 7-3-1 Hongo, Bunkyo-ku, Tokyo 113-8655, Japan.
J Biomech 2018 Nov 29. Epub 2018 Nov 29.
Department of Mechanical Engineering, Colorado School of Mines, Golden, CO 80401, United States. Electronic address:
Cerebral palsy (CP) is a neurological disorder that results in life-long mobility impairments. Musculoskeletal models used to investigate mobility deficits for children with CP often lack subject-specific characteristics such as altered muscle strength, despite a high prevalence of muscle weakness in this population. We hypothesized that incorporating subject-specific strength scaling within musculoskeletal models of children with CP would improve accuracy of muscle excitation predictions in walking simulations. Read More
Int J Med Inform 2019 Jan 26;121:1-9. Epub 2018 Oct 26.
School of Public Health, Sydney Medical School, University of Sydney, Sydney, NSW, Australia; Institute for Musculoskeletal Health, Sydney Local Health District, Sydney, NSW, Australia.
Background: In 2014-2015, the Physiotherapy Evidence Database (PEDro) was searched poorly by users; few search commands used sophisticated features and ∼20% contained errors. To improve the quality of PEDro searches, users now receive error messages when using incorrect search commands and have access to video tutorials.
Objectives: To determine whether search quality has improved since error messages and tutorials were implemented; and evaluate the content of PEDro searches. Read More
Consult Pharm 2018 Dec;33(12):691-701
: Review the clinical manifestations and treatment of primary Sjögren's syndrome. : Articles indexed in PubMed, Scopus, and the Cochrane Library in the past 10 years using the key words "Sjögren," "Sjögren's syndrome," "Sjögren's disease," and "Sjögren's syndrome AND treatment." Primary sources were used to locate additional resources. Read More
BMC Med Educ 2018 Dec 13;18(1):306. Epub 2018 Dec 13.
University of Sheffield Medical School, University of Sheffield, Sheffield, UK.
The UK is currently facing an inactivity crises, with 1 in 5 children currently meeting physical activity guidelines (Health Survey for England, Children's Health, 2016). To combat this growing problem there has been increased interest in promoting exercise and healthy lifestyle advise to patients as a method for improving public health. In line with this, the specialty of Sports and Exercise Medicine (SEM) has been gaining momentum and is now a recognised specialty with a higher specialist training programme. Read More
BMC Musculoskelet Disord 2018 Dec 13;19(1):440. Epub 2018 Dec 13.
Department of Radiology, Saitama Medical University, 38 Morohongo, Moroyama-machi, Iruma-gun, Saitama, 350-0495, Japan.
Background: Newly developed simultaneous multi-slice (SMS) scans are now being introduced as a clinical application in neuroimaging. We examined the feasibility of SMS scans for joint imaging. The purpose of the present study was to prospectively compare the resolution and specific absorption rate (SAR) obtained using SMS to those of conventional methods in hip joint magnetic resonance imaging (MRI) and establish whether imaging times may be reduced using SMS in 3 T MRI and if image quality is affected. Read More
J Clin Med 2018 Dec 12;7(12). Epub 2018 Dec 12.
Department of Nursing, University Center of Plasencia, University of Extremadura, 10600 Plasencia, Spain.
Based on changes in lung function and musculoskeletal disorders in patients with asthma, this study aimed to compare the tarsal tunnel and fibular bone pressure pain thresholds (PPTs) of patients with asthma and healthy matched-paired controls. A case-control study was performed. One hundred participants were recruited: 50 asthma patients and 50 healthy matched-paired controls. Read More
Int J Mol Sci 2018 Dec 11;19(12). Epub 2018 Dec 11.
Centre of Polymer Systems, University Institute, Tomas Bata University in Zlin, Trida Tomase Bati 5678, 760 01 Zlín, Czech Republic.
The principal focus of this work is the in-depth analysis of the biological efficiency of inorganic calcium-filled bacterial cellulose (BC) based hydrogel scaffolds for their future use in bone tissue engineering/bioengineering. Inorganic calcium was filled in the form of calcium phosphate (β-tri calcium phosphate (β-TCP) and hydroxyapatite (HA)) and calcium carbonate (CaCO₃). The additional calcium, CaCO₃ was incorporated following bio-mineralization. Read More
Int J Environ Res Public Health 2018 Dec 10;15(12). Epub 2018 Dec 10.
School of Medicine and Health Management, Tongji medical college, Huazhong University of Science and Technology, Wuhan 430030, China.
Chronic musculoskeletal pain (CMP) is a serious health concern especially among the elderly population and has significant bearing on health and quality of life. Not much is known about the relationship between chronic pain with self-reported health and quality of life among older populations in low-resource settings. Based on sub-national data from South Africa and Uganda, the present study aimed to explore whether the older population living with CMP report health and quality of life differently compared to those with no CMP complaints. Read More
Nutrients 2018 Dec 7;10(12). Epub 2018 Dec 7.
Research Centre for Musculoskeletal Science & Sports Medicine, Department of Exercise and Sport Science, Manchester Metropolitan University Cheshire, Crewe CW1 5DU, UK.
The aim of this study was to determine the response to an oral glucose tolerance test (OGTT) in adult males with Becker muscular dystrophy (BMD) and Duchenne muscular dystrophy (DMD), and to investigate whether body composition contributes to any variance in the glucose response. Twenty-eight adult males with dystrophinopathy (BMD, = 13; DMD, = 15) and 12 non-dystrophic controls, ingested 75 g oral anhydrous glucose solution. Fingertip capillary samples were assessed for glucose at 30-min intervals over 2-h post glucose ingestion. Read More
Medicine (Baltimore) 2018 Dec;97(49):e13534
Department of Spine Surgery, The First Affiliated Hospital of Guangxi Medical University, Nanning, China.
Study Design: Systematic review and meta-analysis.
Background: Anchor screw fixation and mini-plate fixation are widely used in unilateral open-door laminoplasty. There is a great controversy over the preferred fixation method. Read More
Medicine (Baltimore) 2018 Dec;97(49):e13455
Department of Physical Medicine and Rehabilitation, Tung's Taichung Metroharbor Hospital, Taichung, Taiwan.
Rationale: Compressive radial neuropathy by a synovial cyst in the radial tunnel during pregnancy is a rare occurrence. The management of radial nerve compression caused by a synovial cyst in a pregnant patient is a surgical dilemma owing to the fetal and maternal risks of treatment.
Patient Concerns And Diagnosis: A 37-year-old pregnant woman presented with progressive forearm pain at the gestational age of 12 weeks. Read More
J Gerontol A Biol Sci Med Sci 2018 Dec 13. Epub 2018 Dec 13.
Department of Pathophysiology and Therapeutics of Diabetic Vascular Complications, Kurume University School of Medicine, Kurume, Japan.
Nutr Rev 2018 Dec 13. Epub 2018 Dec 13.
Ageing Clinical & Experimental Research (ACER) Team, Institute of Applied Health Sciences, School of Medicine, Medical Sciences and Nutrition, University of Aberdeen, Aberdeen, United Kingdom.
Context: Care home residents are at risk of malnutrition owing to reduced food intake, anabolic resistance in aging muscle, and a high prevalence of medical morbidity and functional dependency. There has been limited consensus regarding the effectiveness of a high-protein diet on quality of life or clinical outcomes in care home residents.
Objective: The aim of this review was to evaluate the effectiveness of nonmeat, high-protein supplementation on health-related quality of life (HRQOL) and relevant clinical and nutritional outcomes in older people in a care home setting. Read More
Clin Biomech (Bristol, Avon) 2018 Dec 6;61:95-104. Epub 2018 Dec 6.
Department of Anatomy, University of Otago, Dunedin, New Zealand; Department of Trauma, Orthopedic and Plastic Surgery, University Hospital of Leipzig, Germany; Orthopaedicus Clinics, Leipzig, Germany.
Background: Computational models of the human pelvis have become highly useful tools to assess mechanisms of injury, diagnostics and treatment options. The purpose of this systematic literature review was to summarize existing pelvic computer models, to assess their comparability and the measures taken for experimental validation.
Methods: Research on virtual simulations of the posterior pelvis and sacroiliac joint available from the ISI Web of Knowledge, PubMed and Scopus databases available until January 2018 were included. Read More
Clin Immunol 2018 Dec 10. Epub 2018 Dec 10.
Zabludowicz Center for Autoimmune Diseases, Tel-Aviv University, Israel.; Sackler Faculty of Medicine, Tel-Aviv University, Israel.
Am J Sports Med 2018 Dec 13:363546518813915. Epub 2018 Dec 13.
Sports Medicine Service, Hospital for Special Surgery, New York, New York, USA.
Background:: Poor osseous integration after fresh osteochondral allograft transplantation (OCA) may be associated with graft subsidence and subchondral bone collapse after implantation. The augmentation of OCA with bone marrow aspirate concentrate (BMAC) has been hypothesized to improve osseous incorporation of the implanted allograft.
Purpose:: To evaluate the effect of autogenous BMAC treatment on osseous integration at the graft-host bony interface after OCA. Read More
J Gen Intern Med 2018 Dec 12. Epub 2018 Dec 12.
Yale-Griffin Prevention Research Center, Griffin Hospital, Yale University School of Public Health, Derby, CT, USA.
Background: Current treatment options for knee osteoarthritis have limited effectiveness and potentially adverse side effects. Massage may offer a safe and effective complement to the management of knee osteoarthritis.
Objective: Examine effects of whole-body massage on knee osteoarthritis, compared to active control (light-touch) and usual care. Read More
Neurotherapeutics 2018 Dec 12. Epub 2018 Dec 12.
Division of Plastic and Reconstructive Surgery, Washington University in St. Louis, St. Louis, MO, USA.
Pain is a frequent cause of physician visits. Many physicians find these patients challenging because they often have complicated histories, emotional comorbidities, confusing examinations, difficult problems to fix, and the possibility of factitious complaints for attention or narcotic pain medications. As a result, many patients are lumped into the category of chronic, centralized pain and relegated to pain management. Read More
Arch Orthop Trauma Surg 2018 Dec 12. Epub 2018 Dec 12.
Orthopedic Department, University Hospital Jena, Campus Waldkliniken Eisenberg, Klosterlausnitzer Str. 81, 07607, Eisenberg, Germany.
Introduction: Surgical treatment methods for degenerative spondylolisthesis (decompression versus decompression and fusion) have been critically debated. The medical care situation is almost unknown for either treatment. Therefore, the aim of the present study was to provide information regarding the use of parameters for decision-making and the employment of surgical techniques. Read More
Knee Surg Sports Traumatol Arthrosc 2018 Dec 12. Epub 2018 Dec 12.
Musculoskeletal and Quantitative Imaging Research, Department of Radiology and Biomedical Imaging, University of California, San Francisco, 185 Berry Street, Suite 350, San Francisco, CA, 94107, USA.
Purpose: To investigate, whether cartilage repair surgery for focal osteochondral defects at the knee results in less degenerative changes over 6 years in a MR imaging follow-up than morphologically initially identical defects in non-operated control subjects from the osteoarthritis initiative (OAI).
Methods: A total of 32 individuals received baseline and follow-up MRI. In n = 16 patients with cartilage repair [osteochondral autograft transfer system (OATS), n = 12; spongiosa-augmented matrix-associated autologous chondrocyte implantation (MACI), n = 4] MRI was performed preoperatively and after 5. Read More
Cureus 2018 Oct 5;10(10):e3419. Epub 2018 Oct 5.
Orthopaedics, University of Alabama at Birmingham, Birmingham, USA.
Leiomyomas are benign tumors of smooth muscle origin. They are most commonly found in the uterus, but cutaneous leiomyomas may be occasionally present in the extremities and cause pain secondary to mass effect. Few studies have reported leiomyoma of the foot, and leiomyoma of the heel is particularly rare. Read More
J Virol 2018 Dec 12. Epub 2018 Dec 12.
Thomas H. Gosnell School of Life Sciences, Rochester Institute of Technology, Rochester, New York, USA
The 240-kb phage SPN3US genome encodes 264 gene products, many of which are functionally uncharacterized. We have previously used mass spectrometry to define the proteomes of wild-type and mutant forms of the SPN3US virion. In this study we sought to determine if this technique was suitable for the characterization of the SPN3US proteome during liquid infection. Read More
mSphere 2018 Dec 12;3(6). Epub 2018 Dec 12.
Laboratory of Cellular Oncology, National Cancer Institute, Bethesda, Maryland, USA.
Several immunodeficiencies are associated with high susceptibility to persistent and progressive human papillomavirus (HPV) infection leading to a wide range of cutaneous and mucosal lesions. However, the HPV types most commonly associated with such clinical manifestations in these patients have not been systematically defined. Here, we used virion enrichment, rolling circle amplification, and deep sequencing to identify circular DNA viruses present in skin swabs and/or wart biopsy samples from 48 patients with rare genetic immunodeficiencies, including patients with warts, hypogammaglobulinemia, infections, myelokathexis (WHIM) syndrome, or epidermodysplasia verruciformis (EV). Read More
Trials 2018 Dec 12;19(1):684. Epub 2018 Dec 12.
Bahia School of Medicine and Public Health, Salvador, BA, Brazil.
Background: Elderly people have high rates of functional decline, which compromises independence, self-confidence, and quality of life (QoL). Physical exercise leads to significant improvements in strength, balance, functional mobility, and QoL, but there is still reduced access to this therapeutic strategy due to difficulties in locomotion to training centers or lack of adaptation to the exercise environment.
Methods/design: The purpose of this clinical trial will be to verify the effect of a progressive and semi-supervised, home-based exercise program on the functional mobility, and in the QoL of sedentary elderly people. Read More
Zhonghua Lao Dong Wei Sheng Zhi Ye Bing Za Zhi 2018 Oct;36(10):764-767
Hubei Province Key Laboratory of Occupational Hazard Identification and Control, School of Public Health, Wuhan University of Science and Technology, Wuhan 430065, China.
To investigate the prevalence and risk factors of neck and shoulder pain (NSP) among automobile manufacturing workers and to provide a theoretical basis for prevention of NSP. From November 5 to November 19, 2017, a total 446 works who had worked for more than one year were recruited from an automobile plant by cluster sampling method. Chi square test and unconditional logistic regression were used to exam the relation between influencing factors and NSP. Read More
Sports Med Int Open 2017 Feb 21;1(2):E37-E42. Epub 2017 Feb 21.
Faculty of Health and Sports Science, Juntendo University, Chiba, Japan.
Ground reaction force is often used to predict the potential risk of injuries but may not coincide with the forces applied to commonly injured regions of the foot. This study examined the forces applied to the foot, and the associated moment arms made by three foot strike patterns. 10 male runners ran barefoot along a runway at 3. Read More
Nanoscale 2018 Dec 7. Epub 2018 Dec 7.
Department of Biomedical Engineering, University of Rochester, Rochester, New York, USA. and Center for Oral Biology, University of Rochester, Rochester, New York, USA and Center for Musculoskeletal Research, University of Rochester, Rochester, New York, USA and Department of Chemical Engineering, University of Rochester, Rochester, New York, USA.
Biofilms are surface-bound, structured microbial communities underpinning persistent bacterial infections. Biofilms often create acidic pH microenvironments, providing opportunities to leverage responsive drug delivery systems to improve antibacterial efficacy. Here, the antibacterial efficacy of novel formulations containing pH-responsive polymer nanoparticle carriers (NPCs) and farnesol, a hydrophobic antibacterial drug, were investigated. Read More
Regen Ther 2018 Dec 2;9:116-119. Epub 2018 Nov 2.
President of Hiroshima University, Higashihiroshima, Japan.
Magnetic targeting is a cell delivery system using the magnetic labeling of cells and the magnetic field; it has been developed for minimally invasive cell transplantation. Cell transplantation with both minimal invasiveness and high efficacy on tissue repair can be achieved by this system. Magnetic targeting has been applied for the transplantation of bone marrow mesenchymal stem cells, blood CD133-positive cells, neural progenitor cells, and induced pluripotent stem cells, and for the regeneration of bone, cartilage, skeletal muscles, and the spinal cord. Read More
Ann Occup Environ Med 2018 3;30:67. Epub 2018 Dec 3.
Department of Occupational and Environmental Medicine, Soonchunhyang University Hospital, Seoul, South Korea.
Background: It has been reported that long working hours are hazardous to the workers' health. Especially, work-related musculoskeletal disorders (WMSDs) have been considered as one of the significant health issues in workplace. The objective of this study was to identify the association between long working hours and work-related musculoskeletal symptoms. Read More
Sport Sci Health 2018 29;14(3):503-509. Epub 2018 Mar 29.
1Department of Life Sciences, University of Roehampton, London, UK.
Purpose: This study aimed at investigating whether association between physical activity, and bone density and muscle strength depends on daily activity pattern.
Methods: Loading dose of moderate-to-vigorous physical activity (MVPA) was measured using accelerometer on 54 men ( = 54.1 years) and 59 women ( = 52. Read More
Front Genet 2018 19;9:549. Epub 2018 Nov 19.
Department of Woman, Child and General and Specialized Surgery, University of Campania "L. Vanvitelli" Naples, Italy.
Diamond-Blackfan anemia (DBA) is a rare congenital erythroid aplasia with a highly heterogeneous genetic background; it usually occurs in infancy. Approximately 30-40% of patients have other associated congenital anomalies; in particular, facial anomalies, such as cleft palate, are part of about 10% of the DBA clinical presentations. Pierre Robin sequence (PRS) is a heterogeneous condition, defined by the presence of the triad of glossoptosis, micrognathia and cleft palate; it occurs in 1/8500 to 1/14,000 births. Read More
Eur Spine J 2018 Dec 6. Epub 2018 Dec 6.
Musculoskeletal Health Research Group, Faculty of Health Sciences, The University of Sydney, PO Box 170, Lidcombe, Sydney, 1825, Australia.
Purpose: To investigate associations between anthropometric measures (birthweight, weight gain and current BMI) and back pain; and to determine whether these associations differ between those born with low or full birthweight.
Methods: The cross-sectional associations between the lifetime prevalence of back pain and anthropometric measures (birthweight, weight gain and current BMI) among 2754 adult twins were investigated in three stages: total sample; within-pair case-control for monozygotic and dizygotic twins together; and within-pair case-control analysis separated by dizygotic and monozygotic. Results were expressed as odds ratios (OR) and 95% confidence intervals (CI). Read More
Skeletal Radiol 2018 Dec 6. Epub 2018 Dec 6.
Department of Orthopaedic Surgery, Johns Hopkins University School of Medicine, 601 North Caroline Street, Baltimore, MD, 21287, USA.
Aneurysmal bone cysts are benign, expansile, lytic bone lesions that behave in a locally aggressive manner. Although radiography and computed tomography (CT) can detect the lesion, magnetic resonance imaging (MRI) is ideal for the demonstration of characteristic fluid-fluid levels, extent, and margins. Treatment typically consists of open surgical curettage with the addition of local adjuvants and bone grafting. Read More
Nat Rev Rheumatol 2018 Dec 6. Epub 2018 Dec 6.
Osteoarthritis Research Unit, University of Montreal Hospital Research Centre (CRCHUM), Montreal, Quebec, Canada.
Osteoarthritis (OA) is an extremely common musculoskeletal disease. However, current guidelines are not well suited for diagnosing patients in the early stages of disease and do not discriminate patients for whom the disease might progress rapidly. The most important hurdle in OA management is identifying and classifying patients who will benefit most from treatment. Read More