1,046,560 results match your criteria Muscle & nerve[Journal]


Myofascial Pain.

Semin Neurol 2018 Dec 6;38(6):640-643. Epub 2018 Dec 6.

Department of Neurology, Boston University School of Medicine, Boston, Massachusetts.

Myofascial pain syndromes arise from acute and chronic musculoskeletal pain and often have a referred neuropathic component. It affects more than three quarters of the world's population and is one of the most important and overlooked causes of disability. The origins of pain are thought to reside anywhere between the motor end plate and the fibrous outer covering of the muscle, with involvement of microvasculature and neurotransmitters at the cellular level. Read More

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December 2018
4 Reads

Bilateral Lateral Rectus Recession for the Treatment of Recurrent Exotropia after Bilateral Medial Rectus Resection.

Ophthalmic Res 2018 Dec 6:1-5. Epub 2018 Dec 6.

Department of Ophthalmology, West China Hospital, Sichuan University, Chengdu,

Purpose: To evaluate the efficacy of bilateral lateral rectus muscle recession (BLR) to treat recurrent exotropia after bilateral medial rectus muscle resection (BMR).

Methods: Twenty-four patients who underwent BLR for recurrent exotropia and were followed up for more than 6 months were included in this retrospective study. All of them had prior BMR. Read More

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December 2018

Sestrin 2 Attenuates Rat Hepatic Stellate Cell (HSC) Activation and Liver Fibrosis via an mTOR/AMPK-Dependent Mechanism.

Cell Physiol Biochem 2018 Dec 6;51(5):2111-2122. Epub 2018 Dec 6.

Department of Infectious Diseases, The Third Affiliated Hospital of Wenzhou Medical University, Rui'an,

Background/aims: Sestrin 2 is associated with the pathophysiology of several diseases. The aim of this study was to investigate the effects and potential mechanisms of Sestrin 2 in rat hepatic stellate cells (HSCs) during liver fibrogenesis.

Methods: In this study, Sestrin 2 protein expression was detected in rat HSC-T6 cells challenged with transforming growth factor-β (TGF-β) and in mice treated with carbon tetrachloride (CCl4), a well-known model of hepatic fibrosis. Read More

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December 2018
2 Reads

Effects of anterior tongue strengthening exercises on posterior tongue strength in healthy young adults.

Arch Oral Biol 2018 Nov 28;98:238-242. Epub 2018 Nov 28.

Kawasaki University of Medical Welfare, 288 Matsushima, Kurashiki, Okayama 701-0193, Japan. Electronic address:

Objective: The aim of the present study was to investigate whether anterior tongue muscle strengthening exercises can affect the strength of posterior tongue muscles.

Design: Eleven healthy subjects (20.6 ± 1. Read More

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November 2018
1 Read

Neuromuscular activation of the knee and hip extensor muscles during high-intensity interval and moderate-intensity constant cycling.

J Electromyogr Kinesiol 2018 Nov 28;44:64-69. Epub 2018 Nov 28.

Research Center of Health, Physical Fitness & Sports, Nagoya University, Nagoya, Japan; Graduate School of Education and Human Development, Nagoya University, Nagoya, Japan.

We aimed to test the hypothesis that the magnitude of differences in muscle activation of the knee and hip extensor muscles between high-intensity interval exercise (HIE) and moderate-intensity constant exercise (CE) would be greater for the gluteus maximus than for the quadriceps femoris muscle. Participants were 11 male middle- or long-distance runners. The HIE (4 sets, 4-min induration, performed at 80-85%VO and followed by a 3-min period of cycling at < 30%VO) and CE (28-min, performed at or near 60%VO) were completed on different days, with the total exercise duration and work being identical for both protocols. Read More

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November 2018
2 Reads

Body composition and sarcopenia: the next-generation of personalized oncology and pharmacology?

Pharmacol Ther 2018 Dec 3. Epub 2018 Dec 3.

Department of Medical Oncology, CAncer Research for PErsonalized Medicine (CARPEM), Paris Centre Teaching Hospitals, Paris Descartes University, USPC, Paris, France.

Body composition has gained increasing attention in oncology in recent years due to fact that sarcopenia has been revealed to be a strong prognostic indicator for survival across multiple stages and cancer types and a predictive factor for toxicity and surgery complications. Accumulating evidence over the last decade has unraveled the "pharmacology" of sarcopenia. Lean body mass may be more relevant to define drug dosing than the "classical" body surface area or flat-fixed dosing in patients with cancer. Read More

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December 2018
2 Reads

NEW INSIGHTS ON THE REGULATION OF CANCER CACHEXIA BY N-3 POLYUNSATURATED FATTY ACIDS.

Pharmacol Ther 2018 Dec 3. Epub 2018 Dec 3.

Institute of Physical Activity Sciences and Sports, Cruzeiro do Sul University, Sao Paulo, Brazil,; Institute of Biomedical Sciences, University of Sao Paulo, Sao Paulo, Brazil;. Electronic address:

Cancer cachexia is a multifactorial syndrome that develops during malignant tumor growth. Changes in plasma levels of several hormones and inflammatory factors result in an intense catabolic state, decreased activity of anabolic pathways, anorexia, and marked weight loss, leading to cachexia development and/or accentuation. Inflammatory mediators appear to be related to the control of a highly regulated process of muscle protein degradation that accelerates the process of cachexia. Read More

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December 2018
2 Reads

Novel metabolic disorders in skeletal muscle of Lipodystrophic Bscl2/Seipin deficient mice.

Mol Cell Endocrinol 2018 Dec 3. Epub 2018 Dec 3.

Department of Physiology, Medical College of Georgia at Augusta University, Augusta, GA, 30912, USA. Electronic address:

Bscl2 mice recapitulate many of the major metabolic manifestations in Berardinelli-Seip congenital lipodystrophy type 2 (BSCL2) individuals, including lipodystrophy, hepatosteatosis, muscular hypertrophy, and insulin resistance. Metabolic defects in Bscl2 mice with regard to glucose and lipid metabolism in skeletal muscle have never been investigated. Here, we identified Bscl2 mice displayed reduced intramyocellular triglyceride (IMTG) content but increased glycogen storage predominantly in oxidative type I soleus muscle (SM). Read More

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December 2018
3 Reads

Development of a respiratory disease model for enterovirus D68 in 4-week-Old mice for evaluation of antiviral therapies.

Antiviral Res 2018 Dec 3. Epub 2018 Dec 3.

Institute for Antiviral Research, Utah State University, Logan, UT, United States; Department of Animal, Dairy and Veterinary Sciences, Utah State University, Logan, UT, United States; Utah Veterinary Diagnostic Laboratory, Logan, UT, United States. Electronic address:

Enterovirus D68 (EV-D68) is a non-polio enterovirus that affects the respiratory system and can cause serious complications, especially in children and older people with weakened immune systems. As an emerging virus, there are no current antiviral therapies or vaccines available. Our goal was to develop a mouse model of human EV-D68 infection that mimicked the disease observed in humans and could be used for evaluation of experimental therapeutics. Read More

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December 2018
6 Reads

Time-dependently slow-released multiple-drug eluting external sheath for efficient long-term inhibition of saphenous vein graft failure.

J Control Release 2018 Dec 3. Epub 2018 Dec 3.

Department of Cardiac Surgery, First Affiliated Hospital, China Medical University, Shenyang, PR China. Electronic address:

Coronary artery bypass graft surgery (CABG) is an effective therapeutic method for coronary artery disease. Great saphenous vein is the predominant graft due to the accessibility, sufficient length and suitable size matching with coronary artery. However, saphenous vein graft failure (SVGF) always restrict the long-term success of CABG. Read More

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December 2018
1 Read

Anti-inflammatory and antioxidant effect of melatonin on recovery from muscular trauma induced in rats.

Exp Mol Pathol 2018 Dec 3. Epub 2018 Dec 3.

Universidade Luterana do Brasil - ULBRA - Graduate Program in Genetics and Applied Toxicology, Canoas, Rio Grande do Sul, Brazil; Universidade Luterana do Brasil - ULBRA - Graduate Program in Cellular and Molecular Biology Applied to Health, Canoas, Rio Grande do Sul, Brazil; Universidade Federal do Rio Grande do Sul - UFRGS - Graduate Program in Medicine: Medical Sciences, Porto Alegre, Rio Grande do Sul, Brazil; Universidade Luterana do Brasil - Laboratory of Oxidative Stress and Antioxidants, Canoas, Rio Grande do Sul, Brazil; Hospital de Clínicas de Porto Alegre - HCPA - Laboratory of Experimental Hepatology and Gastroenterology, Porto Alegre, Rio Grande do Sul, Brazil. Electronic address:

In recent decades, the number of people who practice sports has grown exponentially, increasing the number of muscular injuries. Trauma injury occurs when the muscle is exposed to a sudden compression force. Melatonin (MLT) has often been cited in the literature as a potent antioxidant and anti-inflammatory agent. Read More

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December 2018
1 Read

Epithelial-Mesenchymal Transdifferentiation in Pediatric Lens Epithelial Cells.

Invest Ophthalmol Vis Sci 2018 Dec;59(15):5785-5794

Department of Ophthalmology, Charité - Universitätsmedizin Berlin, corporate member of Freie Universität Berlin, Humboldt-Universität zu Berlin, and Berlin Institute of Health, Berlin, Germany.

Purpose: Posterior capsule opacification (PCO) is a complication after cataract surgery, particularly in children. Epithelial-mesenchymal transition (EMT) of lens epithelial cells, mediated by transforming growth factor beta (TGFβ), contributes to PCO. However, its pathogenesis in children is poorly understood. Read More

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December 2018
3 Reads

Magnetic resonance imaging quantification of dehydration and rehydration in vocal fold tissue layers.

PLoS One 2018 6;13(12):e0208763. Epub 2018 Dec 6.

Division of Otolaryngology, Department of Surgery, University of Wisconsin-Madison, Madison, Wisconsin, United States of America.

Clinicians commonly recommend increased hydration to patients with voice disorders. However, effects on clinical voice outcome measures have been inconsistent. Hydration-induced change within different layers of vocal fold tissue is currently unknown. Read More

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December 2018
1 Read

ATF2 promotes urothelial cancer outgrowth via cooperation with androgen receptor signaling.

Endocr Connect 2018 Dec;7(12):1397-1408

Department of Pathology & Laboratory Medicine, University of Rochester Medical Center, Rochester, New York, USA.

We investigated the functional role of ATF2, a transcription factor normally activated via its phosphorylation in response to phospho-ERK/MAPK signals, in the outgrowth of urothelial cancer. In both neoplastic and non-neoplastic urothelial cells, the expression levels of androgen receptor (AR) correlated with those of phospho-ATF2. Dihydrotestosterone treatment in AR-positive bladder cancer cells also induced the expression of phospho-ATF2 and phospho-ERK as well as nuclear translocation and transcriptional activity of ATF2. Read More

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December 2018

[Foodbourne Botulism: A Forgotten Disease].

Acta Med Port 2018 Nov 30;31(11):691-693. Epub 2018 Nov 30.

Serviço de Medicina Interna. Hospital Sousa Martins. Guarda. Portugal.

Botulism is a serious illness caused by exposure to botulinum toxin. It is manifested by flaccid, paralysis, symmetric and in descending pattern affecting cranial and peripheral nerves. Given the frequent need for invasive mechanical ventilation, these patients should be approached in an intensive care setting. Read More

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November 2018

Effects of weight loss on dynamic hyperinflation in women obese asthmatics.

J Appl Physiol (1985) 2018 Dec 6. Epub 2018 Dec 6.

Physical Therapy, School of Medicine, Brazil.

Obese adults with asthma are more likely to develop dynamic hyperinflation (DH) and expiratory flow limitation (EFL) than non-obese asthmatics, and weight-loss seems to improve the breathing mechanics during exercise. However, studies evaluating the effect of weight-loss on DH in obese adults with asthma have not been performed.

Objective: To evaluate the effect of a weight-loss program on DH in obese adults with asthma. Read More

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December 2018

An integrated method for quantitative morphometry and oxygen transport modelling in striated muscle.

J Appl Physiol (1985) 2018 Dec 6. Epub 2018 Dec 6.

Biomedical Sciences, University of Leeds, United Kingdom.

Identifying structural limitations in O transport is primarily restricted by current methods employed to characterise the nature of physiological remodelling. Inadequate resolution or breadth of available data has impaired development of routine diagnostic protocols and effective therapeutic strategies. Understanding O transport within striated muscle faces major challenges, most notably in quantifying how well individual fibres are supplied by the microcirculation, which has necessitated exploring tissue O supply using theoretical modelling of diffusive exchange. Read More

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December 2018
1 Read

Reflex response to airway occlusion in human inspiratory muscles when recruited for breathing and posture.

J Appl Physiol (1985) 2018 Dec 6. Epub 2018 Dec 6.

Neuroscience Research Australia and The University of New South Wales, Sydney, Australia.

Briefly occluding the airway during inspiration produces a short-latency reflex inhibition in human inspiratory muscles. This occlusion reflex seems specific to respiratory muscles; however, it is not known whether the reflex inhibition has a uniform effect across a motoneurone pool when a muscle is recruited concurrently for breathing and posture. In this study, participants were seated and breathed through a mouthpiece that occluded inspiratory airflow for 250 ms at a volume threshold of 0. Read More

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December 2018
2 Reads

Titin as a force generating muscle protein under regulatory control.

J Appl Physiol (1985) 2018 Dec 6. Epub 2018 Dec 6.

Institute of Physiology II, University of Muenster, Germany.

Titin has long been recognized as a mechanical protein in muscle cells that has a main function as a molecular spring in the contractile units, the sarcomeres. Recent work suggests that the titin spring contributes to muscle contraction in a more active manner than previously thought. In this review, we highlight this property, specifically the ability of the immunoglobulin-like (Ig) domains of titin to undergo unfolding-refolding transitions when isolated titin molecules or skeletal myofibrils are held at physiological force levels. Read More

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December 2018

The Effects of Load Stability and Visual Access During Asymmetric Lifting Tasks on Back and Upper Extremity Biomechanical Responses.

Hum Factors 2018 Dec 6:18720818814107. Epub 2018 Dec 6.

The Ohio State University, Columbus.

Objective:: To explore the change of muscular and biomechanical responses in different load stability and visual access conditions during an asymmetric lifting task.

Background:: Previous studies found that lifting unstable loads resulted in changes to the biomechanical loads experienced by the spine and upper extremities. However, researchers have not extensively investigated behaviors when people lift potentially unstable loads. Read More

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December 2018

Laparoscopic approach for intravesical surgery using pneumovesicum in the management of anterior colporrhaphy mesh erosion and stones around the bladder neck.

Int Braz J Urol 2018 Sep 20;44. Epub 2018 Sep 20.

Department of Urology, Korea University Ansan Hospital, Korea University College of Medicine, Korea.

Introduction And Objective: Perforation of the bladder or urethra and erosion of the mesh after cystocele repair surgery are not uncommon and have potentially serious complications. Traditionally, surgical management of such complications has involved excision of the mesh using either a transurethral approach or open surgery. In this video, we present our experience of laparoscopic transvesical surgery for exposed mesh and stone. Read More

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September 2018

Medial elbow anatomy: A paradigm shift for UCL injury prevention and management.

Clin Anat 2018 Dec 6. Epub 2018 Dec 6.

Department of Clinical Anatomy, Graduate School of Medical and Dental Science, Tokyo Medical and Dental University, Tokyo, Japan.

Introduction: To improve the management outcomes and diagnostic accuracy of the ulnar collateral ligament (UCL) injury, the anatomy of the medial side of the elbow joint is necessary to be understood in terms of the periarticular surroundings rather than the specific ligaments. The aim of this study was to anatomically clarify the medial side of the elbow joint in terms of the tendinous structures and joint capsule.

Materials And Methods: We conducted a descriptive anatomical study of 23 embalmed cadaveric elbows. Read More

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December 2018

A secretory pathway kinase regulates sarcoplasmic reticulum Ca homeostasis and protects against heart failure.

Elife 2018 Dec 6;7. Epub 2018 Dec 6.

Department of Pharmacology, University of California, San Diego, La Jolla, United States.

Ca signaling is important for many cellular and physiological processes, including cardiac function. Although sarcoplasmic reticulum (SR) proteins involved in Ca signaling have been shown to be phosphorylated, the biochemical and physiological roles of protein phosphorylation within the lumen of the SR remain essentially uncharacterized. Our laboratory recently identified an atypical protein kinase, Fam20C, which is uniquely localized to the secretory pathway lumen. Read More

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December 2018
2 Reads

Posturographic and ankle muscle activation characteristics in patients with haemophilia.

Haemophilia 2018 Dec 6. Epub 2018 Dec 6.

Department of Sports Medicine, University of Wuppertal, Wuppertal, Germany.

Introduction: The objective of this work was to examine the interrelations of posturographic and surface EMG (SEMG) characteristics of ankle muscles in patients with haemophilia while standing naturally.

Methods: Surface EMG of five bilaterally recorded ankle muscles was conducted in 24 patients with haemophilia (PwH, age: 42 [11] years, mean [SD], 22 A, 2 B, 21 severe, 3 moderate) with median (quartiles) WFH orthopaedic joint score of 30 (20/39) points and 24 non-haemophilic controls (Con, age: 42 [12]). Force plate (IBS) signals were captured simultaneously during bipedal stance with eyes open. Read More

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December 2018
1 Read

Dermoscopy of cutaneous smooth muscle neoplasms: a morphological study of 136 cases.

J Eur Acad Dermatol Venereol 2018 Dec 6. Epub 2018 Dec 6.

Dermatology Department. Hospital, Universitario de Alicante. ISABIAL. Miguel Hernandez University. Sant Joan de Alicante, Spain.

Background: A variety of cutaneous smooth muscle neoplasms may arise in the skin and are frequently unrecognized by clinicians. There is sparse data relating to the dermoscopy of piloleiomyiomas (PL) and nothing has been published about the dermoscopy of angioleiomyomas (AL) and leiomyosarcomas (LS).

Objectives: To evaluate the morphological findings of a large series of cutaneous PL, AL and LS under dermoscopic observation, comparing these findings among them. Read More

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December 2018
3 Reads

Force analysis of shoulder joint muscles in the early phase of brain stroke.

Acta Bioeng Biomech 2018 ;20(4):107-113

Department of Physical Medicine, Medical University of Lodz, Łódź, Poland.

Purpose: Upper limb impairment in the early phase of brain stroke is one of the key problems in rehabilitation. An estimation of muscle force can be a helpful factor for functional improvement after a stroke. The primary goals of this study were to determine the muscles with the lowest force in the affected (A) and non-affected (non-A) upper limb. Read More

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January 2018
2 Reads

Are the knee extensor and flexor muscles isokinetic parameters affected by the duration of postoperative physiotherapy supervision in patients eight months after ACL reconstruction with the use of semitendinosus and gracilis tendons autograft?

Acta Bioeng Biomech 2018 ;20(4):89-100

Division of Sports Medicine, Wrocław Medical University, Wrocław, Poland.

Purpose: The observational study evaluated isokinetic parameters in patients at eight months after anterior cruciate ligament reconstruction (ACLR) utilizing semitendinosus and gracilis tendons autograft, with two different modes of physiotherapy, and investigated whether analysed parameters were affected by the postoperative physiotherapy supervision duration.

Methods: Strict exclusion criteria were employed on a group of 259 ACL-reconstructed patients to identify two groups of males preoperatively well trained and frequently participating in sports, with different durations of postoperative physiotherapy supervision: Group I (n = 18; x = 27.67 weeks) and Group II (n = 20; x = 10. Read More

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January 2018

Influence of number of records on reliability of myotonometric measurements of muscle stiffness at rest and contraction.

Acta Bioeng Biomech 2018 ;20(4):123-131

Department of Kinesiology, Faculty of Physiotherapy, University School of Physical Education, Wrocław, Poland.

Purpose: The aim of this study was to determine an effect of myotonometric records' number on stiffness measurements' reliability in muscles at rest and contraction.

Methods: Muscle stiffness was measured using Myoton-3 device. Twenty records were taken for: (i) biceps (BB) and triceps brachii (TB) at rest and for BB at 10% of maximal voluntary contraction (MVC) in healthy elderlies (HE) and in Parkinson's disease patients (PD); and (ii) brachioradialis (BR) at rest and at 25, 50 and 80% MVC in healthy young (HY) subjects. Read More

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January 2018

Changes in electromyographic signals and skin temperature during standardised effort in volleyball players.

Acta Bioeng Biomech 2018 ;20(4):115-122

Józef Piłsudski University of Physical Education, Faculty of Physical Education and Sport, Department of Biomechanics and Computer Science, Biała Podlaska, Poland.

Purpose: The state of athletes' muscles is not constant, but it differs depending on the stage of sports training, which is associated with different degrees of muscle fatigue. There is thus a need to find a non-invasive and simple method to assess muscle fatigue. The aim of the study was to determine the relationship between muscle fatigue due to physical effort and changes in skin temperature, measured using a thermographic camera. Read More

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January 2018
2 Reads

Diagnostic Value of HLA Typing in Pathogenesis of Cardiomyopathy.

Cardiovasc Hematol Disord Drug Targets 2018 Dec 5. Epub 2018 Dec 5.

Thalassemia and Hemoglobinopathy Research Center, Research Institute of Health, Ahvaz Jundishapur University of Medical Sciences, Ahvaz. Iran.

Development of cardiomyopathy (CM) is dependent upon several factors. However, reaction of immune response against myocardial tissue due to microbial and viral infections plays an important role in this disease. Therefore, the purpose of this study is to investigate the relationship between HLAs and their pathogenic mechanisms in the incidence of CM. Read More

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December 2018

Transforming Growth Factor Beta-1 Promotes Smooth Muscle Cell Proliferation and Migration in an Arteriovenous Fistulae, the Role of Wall Shear Stress.

Ther Apher Dial 2018 Dec 6. Epub 2018 Dec 6.

Department of Kidney Disease and Blood Purification, Institute of Urology & Key Laboratory of Tianjin, The Second Hospital of Tianjin Medical University, Tianjin, China.

Background: The wall shear stress (WSS) as a mechanical stimuli to venous wall has a significant role in neointimal hyperplasia of arteriovenous fistulae (AVF), which is often related to the proliferation and migration of vascular smooth muscle cells(VSMCs). Transforming growth factor beta-1 (TGF-β1) has the function of promoting VSMCs proliferation and migration. Our study is to detect that the correlation between WSS, TGF-β1, VSMCs proliferation and neointimal hyperplasia. Read More

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December 2018
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