1,060,672 results match your criteria Muscle & nerve[Journal]


Contribution of Palmar Radiocarpal and Ulnocarpal Ligaments to the Stability of the Canine Antebrachiocarpal Joint.

Vet Comp Orthop Traumatol 2019 Apr 18. Epub 2019 Apr 18.

The Laboratory of Biomechanics, Koret School of Veterinary Medicine, The Hebrew University of Jerusalem, Rehovot, Israel.

Objective:  The aim of this study was to evaluate the contribution of the palmar radiocarpal ligament and the palmar ulnocarpal ligament to canine antebrachiocarpal joint stability.

Materials And Methods:  The right carpus of four dog cadavers, free of musculoskeletal pathology, was stripped of muscle. Each specimen was placed into a custom-made joint testing machine and tested at 15° extension, and 0° and 15° flexion. Read More

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http://dx.doi.org/10.1055/s-0039-1685208DOI Listing

Repeat Surgery for Patients Operated in Childhood for Early-Onset Esotropia and Suffering from Persistent Residual, Recurrent or Consecutive Strabismus.

Klin Monbl Augenheilkd 2019 Apr 18;236(4):446-450. Epub 2019 Apr 18.

Pediatric Ophthalmology, Vision Rive Droite, Le Grand Saconnex, Switzerland.

Background: Patients operated in childhood for early esotropia may suffer from persistent strabismus, whether residual, recurrent, or consecutive, usually with a more complex oculomotor imbalance than in primitive strabismus.

History And Signs: The clinical data are fundamental, in particular, (1) the basic accommodation-free deviation, (2) the horizontal far/near incomitance, (3) the cyclovertical incomitances and/or A or V pattern, and (4) the motility restrictions. In complicated cases, magnetic resonance tomography of the orbits showed the anomalies of the eye and muscle position. Read More

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http://dx.doi.org/10.1055/a-0859-6974DOI Listing

Plication versus Resection in Horizontal Strabismus Surgery.

Klin Monbl Augenheilkd 2019 Apr 18;236(4):442-445. Epub 2019 Apr 18.

University Eye Hospital Basel, Basel, Switzerland.

Background: To compare two commonly used strengthening procedures in strabismus surgery: plication and resection of the extraocular muscle (EOM).

Patients And Methods: From an anonymous databank of strabismus surgeries, performed at the University Eye Hospital Basel, patients with a horizontal strabismus surgery, consisting of a recession combined with either plication or resection of the antagonist and a follow-up of at least 3 months, were included. Exclusion criteria were previous eye surgeries, binocular surgeries, and simultaneous surgery of oblique or vertical EOM. Read More

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http://dx.doi.org/10.1055/a-0829-6086DOI Listing

The Impact of Using Emotionally Arousing Stimuli on Muscle Response Testing Accuracy.

Complement Med Res 2019 Apr 18:1-9. Epub 2019 Apr 18.

School of Health Sciences, City University London, London, United Kingdom.

Introduction: Muscle response testing (MRT) is an assessment method used by 1 million practitioners worldwide, yet its usefulness remains uncertain. The aim of this study, one in a series assessing the accuracy of MRT, was to determine whether emotionally arousing stimuli influence its accuracy compared to neutral stimuli.

Methods: To assess diagnostic test accuracy 20 MRT practitioners were paired with 20 test patients (TPs). Read More

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http://dx.doi.org/10.1159/000497188DOI Listing

High soluble CGA levels are associated with poor survival in bladder cancer.

Endocr Connect 2019 Apr 1. Epub 2019 Apr 1.

H Reis, Institute of Pathology , University of Essen-Duisburg, Essen, Germany.

Recently, a neuroendocrine-like molecular subtype has been discovered in muscle-invasive urothelial bladder cancer (BC). Chromogranin A (CGA) is a widely used tissue and serum marker in neuroendocrine tumors. Our aim was to evaluate serum CGA (sCGA) concentrations and their associations with clinical and follow-up data in BC and renal cell carcinoma (RCC). Read More

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http://dx.doi.org/10.1530/EC-19-0068DOI Listing

Gluteus medius activity during gait is altered in individuals with chronic ankle instability: An ultrasound imaging study.

Gait Posture 2019 Apr 11;71:7-13. Epub 2019 Apr 11.

University of Virginia Exercise and Sports Injury Lab, 210 Emmet Street South, Charlottesville, VA, 22904-4407, United States. Electronic address:

Background: Altered gait mechanics are frequently reported in individuals with chronic ankle instability (CAI), and increasing information suggests proximal muscle adaptations occur in this population. Ultrasound imaging (USI) offers a visual means to evaluate muscle activity during movement, and overcomes limitations of electromyography (EMG) to detect hip muscle activity.

Research Question: A descriptive laboratory study was conducted to determine if gluteus maximus (GMAX) and medius (GMED) muscle activity differed throughout gait in patients with CAI compared to healthy counterparts. Read More

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http://dx.doi.org/10.1016/j.gaitpost.2019.04.007DOI Listing

Performance of stair negotiation in patients with cerebral palsy and stiff knee gait.

Gait Posture 2019 Apr 9;71:14-19. Epub 2019 Apr 9.

Clinic for Orthopedics and Trauma Surgery, Heidelberg University Hospital, Schlierbacher Landstrasse 200a, 69118 Heidelberg, Germany; Pediatric Orthopaedics and Traumatology, University, Children's Hospital Zurich - Eleonore Foundation, Steinwiesstrasse 75, 8032 Zurich, Switzerland. Electronic address:

Background: Due to the limited knee range of motion, achieving adequate foot clearance while walking on level ground constitutes a major problem for patients with cerebral palsy and stiff knee gait. Stair negotiation as an activity of daily life requires a considerably higher knee range of motion than level ground walking, but little is known yet as to whether such patients are able to walk stairs.

Research Question: The aim of this study was to investigate how patients with a limited knee range of motion negotiate stairs. Read More

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https://linkinghub.elsevier.com/retrieve/pii/S09666362183178
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http://dx.doi.org/10.1016/j.gaitpost.2019.04.005DOI Listing
April 2019
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Ca-induced sarcoplasmic reticulum Ca release in myotubularin-deficient muscle fibers.

Cell Calcium 2019 Apr 10;80:91-100. Epub 2019 Apr 10.

Univ Lyon, Université Claude Bernard Lyon 1, CNRS UMR-5310, INSERM U-1217, Institut NeuroMyoGène, 8 avenue Rockefeller, 69373, Lyon, France. Electronic address:

Skeletal muscle deficiency in the 3-phosphoinositide (PtdInsP) phosphatase myotubularin (MTM1) causes myotubular myopathy which is associated with severe depression of voltage-activated sarcoplasmic reticulum Ca release through ryanodine receptors. In the present study we aimed at further understanding how Ca release is altered in MTM1-deficient muscle fibers, at rest and during activation. While in wild-type muscle fibers, SR Ca release exhibits fast stereotyped kinetics of activation and decay throughout the voltage range of activation, Ca release in MTM1-deficient muscle fibers exhibits slow and unconventional kinetics at intermediate voltages, suggestive of partial loss of the normal control of ryanodine receptor Ca channel activity. Read More

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http://dx.doi.org/10.1016/j.ceca.2019.04.004DOI Listing

Highly photostable two-photon NIR AIEgens with tunable organelle specificity and deep tissue penetration.

Biomaterials 2019 Apr 9;208:72-82. Epub 2019 Apr 9.

HKUST-Shenzhen Research Institute, No. 9 Yuexing 1st RD, South Area, Hi-tech Park, Nanshan, Shenzhen, 518057, China; Department of Chemistry, Hong Kong Branch of Chinese National Engineering Research Center for Tissue Restoration and Reconstruction, Institute for Advanced Study, Institute of Molecular Functional Materials, And Department of Chemical and Biological Engineering, The Hong Kong University of Science and Technology, Clear Water Bay, Kowloon, 999077, China; Center for Aggregation-Induced Emission, SCUT-HKUST Joint Research Institute, State Key Laboratory of Luminescent Materials and Devices, South China University of Technology, Guangzhou, 510640, China. Electronic address:

Photostability is a particularly important parameter for fluorescence imaging especially long-term dynamic tracking in live samples. However, many organic fluorophores show poor photostability under one-photon and two-photon continuous irradiation. In addition, these traditional fluorophores also suffer from aggregation-caused quenching (ACQ) in aggregate state in insolvable water environment. Read More

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http://dx.doi.org/10.1016/j.biomaterials.2019.04.002DOI Listing

Carbenoxolone ameliorates insulin sensitivity in obese mice induced by high fat diet via regulating the IκB-α/NF-κB pathway and NLRP3 inflammasome.

Biomed Pharmacother 2019 Apr 15;115:108868. Epub 2019 Apr 15.

Department of Geriatrics, the Third Affiliated Hospital of Soochow University, Changzhou, Jiangsu, China.

The characteristic feature of obesity and insulin resistance is chronic low-grade inflammation. Nod-Like Receptor Pyrin 3 (NLRP3) inflammasome plays a central role in obesity-induced insulin resistance. However, how does Carbenoxolone (CBX) play its role in ameliorating insulin resistance in peripheral tissues of obese mice induced by high-fat diet (HFD) remains unknown. Read More

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http://dx.doi.org/10.1016/j.biopha.2019.108868DOI Listing

Molecular regulation of myoendothelial gap junctions.

Curr Opin Pharmacol 2019 Apr 15;45:16-22. Epub 2019 Apr 15.

Walter-Brendel-Centre of Experimental Medicine, University Hospital, LMU Munich, Biomedical Centre, Cardiovascular Physiology, LMU Munich and German Centre for Cardiovascular Research, Partner Site Munich Heart Alliance, Munich, Germany.

Myoendothelial gap junctions are involved in the regulation of vascular tone. The major connexins described in the vascular system are Cx37, Cx40, Cx43, and Cx45 with all but Cx45 found in myoendothelial connections. Although many reports on post-translational modifications of these connexins are available, only few groups have investigated their role in controlling myoendothelial communication and signal propagation. Read More

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http://dx.doi.org/10.1016/j.coph.2019.03.006DOI Listing

Feed and immersion challenges with lymphocystis disease virus (LCDV) reveals specific mechanisms for horizontal transmission and immune response in senegalese sole post-larvae.

Fish Shellfish Immunol 2019 Apr 15. Epub 2019 Apr 15.

IFAPA Centro El Toruño, Junta de Andalucía, Camino Tiro Pichón s/n, 11500, El Puerto de Santa María, Cádiz, Spain. Electronic address:

The horizontal transmission of lymphocystis disease virus (LCDV) through contaminated water and feed (using artemia as vehicle) and the associated immune gene expression profiles in Senegalese sole post-larvae were investigated. All specimens analyzed were positive for LCDV DNA detection at 1-day post-challenge (1 dpc) with the highest viral levels in specimens infected through the immersion route. However, the percentage of LCDV-positive animals and number of viral DNA copies dropped progressively at 2 and 7 dpc. Read More

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http://dx.doi.org/10.1016/j.fsi.2019.04.049DOI Listing

Conditioned Pain Modulation Affects the Withdrawal Reflex Pattern to Nociceptive Stimulation in Humans.

Neuroscience 2019 Apr 15. Epub 2019 Apr 15.

Integrative Neuroscience, SMI®, Dept. of Health Science and Technology, Fredrik Bajers Vej 7, Aalborg, Ø, (9220, ), Aalborg, Denmark; Center for Neuroplasticity and Pain (CNAP), SMI®, Dept. of Health Science and Technology, Fredrik Bajers Vej 7, Aalborg, Ø, (9220, ), Aalborg, Denmark. Electronic address:

Human studies have repeatedly shown that conditioning pain modulation (CPM) exerts an overall descending inhibitory effect over spinal nociceptive activity. Previous studies have reported a reduction of the nociceptive withdrawal reflex (NWR) under CPM. Still, how descending control influences the muscle activation patterns involved in this protective behavior remains unknown. Read More

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http://dx.doi.org/10.1016/j.neuroscience.2019.04.016DOI Listing

Calcium Influx through Muscle nAChR-Channels: One Route, Multiple Roles.

Neuroscience 2019 Apr 15. Epub 2019 Apr 15.

Department of Physiology and Pharmacology, Sapienza University, piazzale Aldo Moro 5, 00185, Rome, Italy; IRCCS Neuromed, Viale dell'Elettronica, 86077, Pozzilli, Italy.

Although Ca influx through muscle nAChR-channels has been described over the past 40 years, its functions remain still poorly understood. In this review we suggest possible roles of Ca entry at all stages of muscle development, summarizing the evidence present in literature. nAChRs are expressed in myoblasts prior to fusion, and can be activated in the absence of an ACh-releasing nerve terminal, with Ca influx likely contributing to regulate cell fusion. Read More

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http://dx.doi.org/10.1016/j.neuroscience.2019.04.011DOI Listing

Downregulation of ATR decreases the responsiveness of BK channels to angiotensin II in patients with hypertension.

J Mol Cell Cardiol 2019 Apr 15. Epub 2019 Apr 15.

Key Lab of Medical Electrophysiology of Ministry of Education and Medical Electrophysiological Key Lab of Sichuan Province, Collaborative Innovation Center for Prevention and Treatment of Cardiovascular Disease, Institute of Cardiovascular Research, Southwest Medical University, Luzhou, Sichuan 646000, China. Electronic address:

Angiotensin II (Ang II) modulates blood pressure via Ang II type 1 receptor (ATR) and type 2 receptor (ATR). The activation of ATR relaxes vascular tone through opening large-conductance Ca-activated potassium (BK) channels in vascular smooth muscle cells (SMCs). In the present study, we studied the role of the ATR-BK pathway in patients with hypertension. Read More

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http://dx.doi.org/10.1016/j.yjmcc.2019.04.013DOI Listing

Surgical Outcomes in Lateral Abdominal Wall Reconstruction: A Comparative Analysis of Surgical Techniques.

J Am Coll Surg 2019 Apr 15. Epub 2019 Apr 15.

Department of Plastic Surgery, The University of Texas MD Anderson Cancer Center, Houston, TX.

Background: Lateral abdominal wall (LAW) myofascial defects are a challenging reconstructive problem, and no consensus exists on their surgical management. We hypothesized that mesh repairs anchored to the non-yielding LAW boundaries [pillar-anchored repairs (PARs)] would provide more durable reconstructions with lower hernia recurrence and bulge occurrence rates compared to mesh repairs anchored to the surrounding oblique muscle complexes [direct repairs (DRs)].

Study Design: We retrospectively reviewed LAW reconstructions at a single center from 2004-2010. Read More

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http://dx.doi.org/10.1016/j.jamcollsurg.2019.03.023DOI Listing

Lipotoxicity reduces β cell survival through islet stellate cell activation regulated by lipid metabolism-related molecules.

Exp Cell Res 2019 Apr 15. Epub 2019 Apr 15.

Department of Endocrinology, Zhongda Hospital, Institute of Diabetes, School of Medicine, Southeast University, Nanjing, China. Electronic address:

Background: Islet stellate cells (ISCs) activation is mainly associated with islet fibrosis, which contributes to the progression of type 2 diabetes. However, the molecular mechanism underlying this process is not fully understood.

Methods: In order to investigate this process the current study examined ectopic fat accumulation in rats with high-fat diet (HFD) induced obesity. Read More

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http://dx.doi.org/10.1016/j.yexcr.2019.04.012DOI Listing

Inhibition of aldose reductase activity stimulates starvation induced autophagy and clears aldehyde protein adducts.

Chem Biol Interact 2019 Apr 15. Epub 2019 Apr 15.

Diabetes and Obesity Center, Department of Medicine, University of Louisville, Louisville, KY, USA; Envirome Institute, Department of Medicine, University of Louisville, Louisville, KY, USA. Electronic address:

Autophagy is a dynamic recycling process that eliminates damaged proteins and cellular organelles to maintain cellular homeostasis. Aldose reductase (AR) catalyzes conversion of glucose to sorbitol. It also catalyzes the reduction of a broad array of saturated and unsaturated aldehydes. Read More

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http://dx.doi.org/10.1016/j.cbi.2019.04.014DOI Listing

Skeletal muscles of hibernating black bears show minimal atrophy and phenotype shifting despite prolonged physical inactivity and starvation.

PLoS One 2019 18;14(4):e0215489. Epub 2019 Apr 18.

Laboratory of Wildlife Biology and Medicine, Graduate School of Veterinary Medicine, Hokkaido University, Hokkaido, Japan.

Hibernating mammals experience prolonged periods of torpor and starvation during winter for up to 5-7 months. Though physical inactivity and malnutrition generally lead to profound loss of muscle mass and metabolic dysfunction in humans, hibernating bears show limited muscle atrophy and can successfully maintain locomotive function. These physiological features in bears allow us to hypothesize that hibernating bears uniquely alter the regulation of protein and energy metabolism in skeletal muscle which then contributes to "muscle atrophy resistance" against continued physical inactivity. Read More

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http://journals.plos.org/plosone/article?id=10.1371/journal.pone.0215489PLOS

TGFβ-activation by dendritic cells drives Th17 induction and intestinal contractility and augments the expulsion of the parasite Trichinella spiralis in mice.

PLoS Pathog 2019 Apr 18;15(4):e1007657. Epub 2019 Apr 18.

Biomedical and Life Sciences, Faculty of Health and Medicine, University of Lancaster, Lancaster, United Kingdom.

Helminths are highly prevalent metazoan parasites that infect over a billion of the world's population. Hosts have evolved numerous mechanisms to drive the expulsion of these parasites via Th2-driven immunity, but these responses must be tightly controlled to prevent equally devastating immunopathology. However, mechanisms that regulate this balance are still unclear. Read More

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http://dx.doi.org/10.1371/journal.ppat.1007657DOI Listing

Identification of the minimum region of flatfish myostatin propeptide (Pep45-65) for myostatin inhibition and its potential to enhance muscle growth and performance in animals.

PLoS One 2019 18;14(4):e0215298. Epub 2019 Apr 18.

Department of Marine Molecular Bioscience, Gangneung-Wonju National University, Gangneung-si, Ganwon-do, Korea.

Myostatin (MSTN) negatively regulates skeletal muscle growth, and its activity is inhibited by the binding of MSTN propeptide (MSTNpro), the N-terminal domain of proMSTN that is proteolytically cleaved from the proMSTN. Partial sequences from the N-terminal side of MSTNpro have shown to be sufficient to inhibit MSTN activity. In this study, to determine the minimum size of flatfish MSTNpro for MSTN inhibition, various truncated forms of flatfish MSTNpro with N-terminal maltose binding protein (MBP) fusion were expressed in E. Read More

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http://journals.plos.org/plosone/article?id=10.1371/journal.pone.0215298PLOS

Influence of Age, Gender and Body Mass Index on the Thickness of the Gluteal Subcutaneous Fat - Implications for Safe Buttock Augmentation Procedures.

Plast Reconstr Surg 2019 Apr 9. Epub 2019 Apr 9.

Department of Medical Education, Albany Medical College, Albany, NY, USA.

Objective: The deep intramuscular approach during buttock augmentation with fat grafting has been associated with a significantly increased risk for pulmonary fat embolism. This study was designed to provide guidance for the injection into the subcutaneous fat i.e. Read More

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http://dx.doi.org/10.1097/PRS.0000000000005707DOI Listing

Outcomes of single versus double fascicular nerve transfers for restoration of elbow flexion in patients with brachial plexus injuries: a systematic review and meta-analysis.

Plast Reconstr Surg 2019 Apr 11. Epub 2019 Apr 11.

Background: Elbow flexion after upper brachial plexus injury may be restored by a nerve transfer from the ulnar nerve to the biceps motor branch with an optional nerve transfer from the median nerve to the brachialis motor branch (single and double fascicular nerve transfer). This meta-analysis assesses the effectiveness of both techniques and the added value of additional reinnervation of the brachialis muscle.

Methods: Comprehensive searches were performed identifying studies concerning restoration of elbow flexion through single and double fascicular nerve transfers. Read More

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http://dx.doi.org/10.1097/PRS.0000000000005720DOI Listing

Does Compensatory Anterior Pelvic Tilt Decrease After Bilateral Periacetabular Osteotomy?

Clin Orthop Relat Res 2019 May;477(5):1168-1175

E. Daley, I. Zaltz, Department of Orthopedic Surgery, Beaumont Health, Royal Oak, MI, USA N. Nahm, Department of Orthopedic Surgery, Henry Ford Hospital, Detroit, MI, USA D. Koueiter, Orthopedic Research Laboratories, Beaumont Health, Royal Oak, MI, USA.

Background: The kinetic link among the lumbar spine, pelvic tilt, and the hip has been hypothesized, but this relationship requires further study in acetabular dysplasia. Anecdotal reports suggest that patients may compensate for acetabular dysplasia with an involuntary increase in anterior pelvic tilt; it is not known if this relationship is affected by acetabular reorientation.

Questions/purposes: (1) Does compensatory pelvic tilt decrease on preoperatively obtained standing AP pelvis radiographs compared with those obtained at a minimum of 6 months after bilateral periacetabular osteotomy (PAO)? (2) Does a modified surrogate measurement of pelvic tilt, the pubic symphysis to sacroiliac (PS-SI) index, correlate with a physical synthetic bones model in which pelvic tilt can be directly measured? (3) Can the PS-SI index demonstrate high interrater reliability?

Methods: We assessed the surgical records of one surgeon, who participates in the longitudinally maintained Academic Network of Conservational Hip Outcomes Research (ANCHOR) registry, for patients who had undergone the second side of a staged bilateral PAO between 2007 and 2016; there were 113 such patients. Read More

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http://dx.doi.org/10.1097/CORR.0000000000000560DOI Listing

Adaptive Hybrid Classifier for Myoelectric Pattern Recognition Against the Interferences of Outlier Motion, Muscle Fatigue, and Electrode Doffing.

IEEE Trans Neural Syst Rehabil Eng 2019 Apr 16. Epub 2019 Apr 16.

Traditional myoelectric prostheses that employ a static pattern recognition model to identify human movement intention from surface electromyography (sEMG) signals hardly adapt to the changes in the sEMG characteristics caused by interferences from daily activities, which hinders the clinical applications of such prostheses. In this study, we focus on methods to reduce or eliminate the impacts of three types of daily interferences on myoelectric pattern recognition (MPR), i.e. Read More

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http://dx.doi.org/10.1109/TNSRE.2019.2911316DOI Listing

Electromyographic analysis in elite swimmers with shoulder pain during a functional task.

Sports Biomech 2019 Apr 18:1-11. Epub 2019 Apr 18.

c Department of Health & Sport Medicine, Faculty of Physical Education and Sport Sciences , University of Tehran , Tehran , Iran.

The purpose of study was to determine and compare electromyographic activity of selected shoulder girdle muscles in elite swimmers with and without shoulder pain. Twelve professional swimmers with shoulder pain (mean age: 18.55 ± 3. Read More

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http://dx.doi.org/10.1080/14763141.2019.1597153DOI Listing

Intravesical electromotive administration of botulinum toxin type A in improving the bladder and bowel functions: Evidence for novel mechanism of action.

J Spinal Cord Med 2019 Apr 18:1-7. Epub 2019 Apr 18.

b Department of pathology , Shariati Hospital, Tehran University of Medical Sciences , Tehran , Iran.

Objective: To examine the hypothesis that what is the concomitant mechanism of action botulinum toxin type A (BoNTA) administration by intravesical electromotive into the bladder resulting in bladder function improvement. We also tried to confirm the possibility of retrograde trans-axonal transportation of toxin.

Design: Animal study. Read More

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http://dx.doi.org/10.1080/10790268.2019.1603490DOI Listing

Spatial Patterning of Molecular Cues and Vascular Cells in Fully Integrated Hydrogel Channels via Interfacial Bioorthogonal Crosslinking.

ACS Appl Mater Interfaces 2019 Apr 18. Epub 2019 Apr 18.

Fully integrated hydrogel channels were fabricated via interfacial bioorthogonal crosslinking - a diffusion-controlled method for the creation and patterning of synthetic matrices based on the rapid bioorthogonal reaction between s-tetrazines (Tz) and trans-cyclooctene (TCO) dienophiles. Injecting an aqueous solution of a bisTCO crosslinker into a reservoir of tetrazine-modified hyaluronic acid (HA-Tz), while simultaneously drawing the syringe needle through the reservoir, yielded a crosslinked hydrogel channel that was mechanically robust. Fluorescent tags and biochemical signals were spatially patterned in the channel wall through time-dependent perfusion of TCO-conjugated molecules into the lumen of the channel. Read More

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http://dx.doi.org/10.1021/acsami.9b04383DOI Listing

ENDOPLASMIC RETICULUM STRESS AND UNFOLDED PROTEIN RESPONSE IN DIAPHRAGM MUSCLE DYSFUNCTION OF PATIENTS WITH STABLE CHRONIC OBSTRUCTIVE PULMONARY DISEASE.

J Appl Physiol (1985) 2019 Apr 18. Epub 2019 Apr 18.

Pulmonology Department-Muscle and Respiratory System Research Unit (URMAR), CEXS, IMIM-Hospital del Mar, UPF, CIBERES, Spain.

Respiratory muscle dysfunction is common in patients with chronic obstructive pulmonary disease (COPD). Chronic contractile activity induces endoplasmic reticulum (ER) stress and unfolded protein response UPR in animals (animals and humans). We hypothesized that the respiratory muscle dysfunction associated with COPD may upregulate ER stress and UPR expression in diaphragm of stable patients with different degrees of airway obstruction and normal body composition. Read More

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http://dx.doi.org/10.1152/japplphysiol.00670.2018DOI Listing

Consecutive bouts of electrical stimulation-induced contractions alter ribosome biogenesis in rat skeletal muscle.

J Appl Physiol (1985) 2019 Apr 18. Epub 2019 Apr 18.

Department of Life Sciences, University of Tokyo, Japan.

Ribosome biogenesis has been implicated in resistance exercise training (RET)-induced skeletal muscle hypertrophy. However, it is unclear how increasing bouts of RET affects ribosome content and biogenesis. This was investigated in the present study using simulated RET where rat skeletal muscle is subjected to increasing bouts of electrical stimulations. Read More

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http://dx.doi.org/10.1152/japplphysiol.00665.2018DOI Listing

Loss of Posterior Occluding Teeth and Its Association with Protein-Micronutrients Intake and Muscle Mass among Thai Elders: A Pilot Study.

J Frailty Aging 2019 ;8(2):100-103

Dunyaporn Trachootham, Institute of Nutrition, Mahidol University, 999 Phutthamonthon Sai 4 Road, Salaya, Nakhon Pathom, Thailand, 73170. E-mail: Tel.: (66) 2 800 2380 ext.326; fax: (66) 2 441 9344.

Contact between upper and lower posterior teeth is crucial for chewing. However, the influence of posterior occluding teeth loss on protein intake and muscle mass was unclear. This cross-sectional study compared consumption frequency of protein food, amount of protein and relevant micronutrient intakes and muscle mass indices among older adults with different Eichner indices (EI) of posterior occluding teeth loss. Read More

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http://dx.doi.org/10.14283/jfa.2019.2DOI Listing
January 2019

Economic Impact of Hospitalizations in US Adults with Sarcopenia.

J Frailty Aging 2019 ;8(2):93-99

Suzette Pereira, Abbott- Nutrition Division, Research and Development, 3300 Stelzer Road, Columbus, OH 43219 Phone: +1 614-624-4625, Fax: 614-727-4625, Email:

Background: Sarcopenia is characterized by progressive loss of muscle mass with corresponding decline in strength and/or physical function. The economic burden of sarcopenia-associated disability is considerable in the US.

Objective: To estimate the cost of hospitalizations in US adults with sarcopenia categorized by age, sex, and race/ethnicity. Read More

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http://dx.doi.org/10.14283/jfa.2019.10DOI Listing
January 2019

Psoas and Paraspinous Muscle Measurements on Computed Tomography Predict Mortality in European Americans with Type 2 Diabetes Mellitus.

J Frailty Aging 2019 ;8(2):72-78

Barry I. Freedman, MD, Internal Medicine - Nephrology, Wake Forest School of Medicine, Medical Center Boulevard, Winston-Salem, NC 27157-1053, Phone: 336-716-6461, Fax: 336-716-4318,

Background: Appendicular skeletal muscle mass index and muscle attenuation (density) are negatively associated with mortality in European-derived populations.

Objectives: The present analyses assessed association between axial skeletal muscle density and muscle index with mortality in European Americans with type 2 diabetes mellitus (T2D).

Design: Single-center observational study. Read More

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http://dx.doi.org/10.14283/jfa.2019.5DOI Listing
January 2019

The Association of ApoE ε4 Status with Lower Limb Function and Handgrip Strength in Older Adults.

J Frailty Aging 2019 ;8(2):62-66

Mathieu Maltais, PhD, Gérontopôle de Toulouse, Institut du Vieillissement, Bâtiment B, 37 Allée Jules Guesde, 31000, Toulouse France, +33 6 74 70 63 71, E-mail :

Background/objectives: Apolipoprotein (ApoE ε4) status has been associated with various cardiovascular diseases and Alzheimer's Disease. Some studies have found a possible relationship between the presence of an ApoE ε4 allele and the decrease of motor function in healthy older adults. The objective of this study was to measure the cross-sectional and prospective associations of ApoE ε4 status with lower limb function and handgrip strength in older adults. Read More

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http://dx.doi.org/10.14283/jfa.2019.7DOI Listing
January 2019

Longitudinal Changes in Muscle Mass and Function in Older Men at Increased Risk for Sarcopenia - The FrOST-Study.

J Frailty Aging 2019 ;8(2):57-61

Professor Dr. Wolfgang Kemmler, Institute of Medical Physics, Friedrich-Alexander University Erlangen-Nürnberg, Henkestrasse 91 91052 Erlangen, Germany, Tel: 0049 9131-8523999, Fax: 0049 9131-8522824, Email:

Background: Declines in muscle mass and function are inevitable developments of the advanced aging process. Corresponding dimensions of longitudinal changes in at-risk populations are still scarce although clinically relevant. The present study monitored changes in morphologic and functional sarcopenia criteria related to sarcopenia in older men with low muscle mass over a period of 24 months. Read More

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http://dx.doi.org/10.14283/jfa.2019.9DOI Listing
January 2019

Role of skeletal muscle on chest computed tomography for risk stratification of lung cancer patients.

J Thorac Dis 2019 Mar;11(Suppl 3):S483-S484

Department of Radiology, Division of Thoracic Imaging and Intervention, Massachusetts General Hospital, Boston, MA, USA.

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http://dx.doi.org/10.21037/jtd.2019.01.73DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6424732PMC

First detection of Erysipelothrix sp. infection in western mosquitofish Gambusia affinis inhabiting catfish aquaculture ponds in Mississippi, USA.

Dis Aquat Organ 2019 Feb;133(1):39-46

Department of Pathology, College of Veterinary Medicine, University of Georgia, 501 D.W. Brooks Drive, Athens, GA 30602, USA.

Native and introduced fish can serve as reservoirs for pathogens of cultured fish species. In the current study, 351 archived western mosquitofish Gambusia affinis collected from experimental catfish production ponds in Mississippi, USA, were surveyed histologically to evaluate their potential as vectors for fish pathogens. In addition to epitheliocystis and multiple metazoan parasites, 8 fish had widespread basophilic colonies of small Gram-positive rods associated primarily with stroma supporting the skeletal muscle and bone, as well as connective tissue components of other tissues and organ systems, such as perivascular adventitia and basement membranes. Read More

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http://dx.doi.org/10.3354/dao03332DOI Listing
February 2019

Effect of Acacia Honey on Transforming Growth Factor-Beta-1-Induced Myofibroblast Differentiation and Matrix Metalloproteinase-9 Production in Nasal Polyp Fibroblasts.

Am J Rhinol Allergy 2019 Apr 18:1945892419843702. Epub 2019 Apr 18.

1 Department of Otolaryngology-Head and Neck Surgery, School of Medicine, Catholic University of Daegu, Daegu, South Korea.

Background: Acacia honey is known to have antioxidant, immune-modulatory, and antiproliferative properties. Nasal fibroblasts participate in local immune responses that control the recruitment of inflammatory cells and the production of extracellular matrix.

Objectives: The aim of this study was to determine the effect of acacia honey on myofibroblast differentiation and matrix metalloproteinase-9 (MMP-9) production in nasal polyp fibroblasts. Read More

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http://dx.doi.org/10.1177/1945892419843702DOI Listing

Evaluation of sarcopenia, sarcopenic obesity, and phase angle in geriatric gastrointestinal cancer patients: before and after chemotherapy

Turk J Med Sci 2019 Apr 18;49(2):583-588. Epub 2019 Apr 18.

Background/aim: The purpose of this study was to determine sarcopenia, sarcopenic obesity and phase angle (PA) and the influence of chemotherapy (CT) on anthropometric measurements and and the PA in in geriatric patients with gastrointestinal (GI) cancer.

Materials And Methods: The anthropometric measurements, calf circumference (CC), upper midarm circumference (UMAC), and hand grip strength (HGS), have been measured to understand muscle function of 153 patients (mean age of 70.5 ± 5. Read More

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http://dx.doi.org/10.3906/sag-1808-114DOI Listing

Efficacy of β-hydroxy-β-methylbutyric acid (HMB) for growing rate and its influence for health indicators in blood test of young early-weaning goats.

Pol J Vet Sci 2019 Mar;22(1):17-24

Department of Sheep and Goat Breeding, Faculty of Animal Bioengineering, University of Warmia and Mazury in Olsztyn, Oczapowskiego 5, 10-917 Olsztyn.

The study was conducted on 26 male, 30 days-old goats, separated from their mothers, divided into two equal groups: I - control and II - experimental, consisting of 13 animals each. All animals were fed with milk replacer, experimental group received additionally 50 g/kg body weight, additive of HMB, for 60 days. The following features were analyzed: body weight, daily increases of body weight, as well as hematological and biochemical blood features. Read More

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http://dx.doi.org/10.24425/pjvs.2018.125596DOI Listing

Evaluation of Lactobacillus spp. and yeast based probiotic (Lavipan) supplementation for the reduction of Salmonella Enteritidis after infection of broiler chickens.

Pol J Vet Sci 2019 Mar;22(1):5-10

Department of Poultry Diseases, Faculty of Veterinary Medicine, University of Warmia and Mazury, Oczapowskiego 13, 10-719 Olsztyn, Poland.

The number of human cases of salmonellosis in the EU was 94,625 in 2015. Considering the source of these infections, Salmonella spp. was most frequently detected in broiler chicken meat and Salmonella Enteritidis (SE) was the most commonly reported serovar. Read More

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http://dx.doi.org/10.24425/pjvs.2018.125616DOI Listing

Asprosin attenuates insulin signaling pathway through PKCδ-activated ER stress and inflammation in skeletal muscle.

J Cell Physiol 2019 Apr 17. Epub 2019 Apr 17.

Department of Pharmacology, College of Medicine, Chung-Ang University, Seoul, Republic of Korea.

It has been reported that asprosin is a novel adipokine which is augmented in mice and humans with type 2 diabetes (T2DM). Asprosin stimulates hepatic gluconeogenesis under fasting conditions. However, the roles of asprosin in inflammation, endoplasmic reticulum (ER) stress, and insulin resistance in skeletal muscle has not been studied. Read More

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http://dx.doi.org/10.1002/jcp.28694DOI Listing

Flexible and comprehensive patient-specific mitral valve silicone models with chordae tendineae made from 3D-printable molds.

Int J Comput Assist Radiol Surg 2019 Apr 17. Epub 2019 Apr 17.

Department of Cardiac Surgery, University Hospital Heidelberg, Heidelberg, Germany.

Purpose: Given the multitude of challenges surgeons face during mitral valve repair surgery, they should have a high confidence in handling of instruments and in the application of surgical techniques before they enter the operating room. Unfortunately, opportunities for surgical training of minimally invasive repair are very limited, leading to a situation where most surgeons undergo a steep learning curve while operating the first patients.

Methods: In order to provide a realistic tool for surgical training, a commercial simulator was augmented by flexible patient-specific mitral valve replica. Read More

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http://dx.doi.org/10.1007/s11548-019-01971-9DOI Listing

Recovery of shoulder abduction in traumatic brachial plexus palsy: a systematic review and meta-analysis of nerve transfer versus nerve graft.

Neurosurg Rev 2019 Apr 17. Epub 2019 Apr 17.

Emory University School of Medicine, 1365-B Clifton Rd NE, Suite B6200, Atlanta, GA, 30322, USA.

Brachial plexus palsy is a surgically manageable condition. Re-animating the shoulder is a high priority for restoring upper extremity function. Methods for reinnervating injured nerves include the transfer of a healthy nerve or fascicle distal to the site of injury, or grafting a healthy sensory nerve to restore motor function. Read More

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http://dx.doi.org/10.1007/s10143-019-01100-9DOI Listing

Clinical Manifestations and Factors Associated with Osteosarcopenic Obesity Syndrome: A Cross-Sectional Study in Koreans with Obesity.

Calcif Tissue Int 2019 Apr 17. Epub 2019 Apr 17.

Division of Endocrinology and Metabolism, Department of Internal Medicine, Catholic Kwandong University College of Medicine, International St. Mary's Hospital, Simgokro 100Gil 25, Seo-gu, Incheon, 22711, South Korea.

Demonstrating the clinical consequences of osteosarcopenic obesity (OSO) is complex. This study evaluated clinical manifestations and factors associated with bone and muscle loss in Koreans with obesity. This cross-sectional observational study enrolled Koreans with obesity aged ≥ 50 years from the Korea National Health and Nutrition Examination Survey. Read More

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http://dx.doi.org/10.1007/s00223-019-00551-yDOI Listing

Transport Mechanisms for the Nutritional Supplement β-Hydroxy-β-Methylbutyrate (HMB) in Mammalian Cells.

Pharm Res 2019 Apr 17;36(6):84. Epub 2019 Apr 17.

Department of Cell Biology and Biochemistry, Texas Tech University Health Sciences Center, 3601 4th Street, Lubbock, TX, 79430-6540, USA.

Purpose: β-Hydroxy-β-methylbutyrate (HMB), a nutritional supplement, elicits anabolic activity in muscle. Here we investigated the mechanism of HMB uptake in muscle cells.

Methods: Murine muscle cells (C2C12) and human mammary epithelial cells (MCF7) were used for uptake. Read More

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http://dx.doi.org/10.1007/s11095-019-2626-3DOI Listing

Anatomic medial complex reconstruction in serious medial knee instability results in excellent mid-term outcomes.

Knee Surg Sports Traumatol Arthrosc 2019 Apr 17. Epub 2019 Apr 17.

Department of Orthopaedic Surgery, KonKuk University Medical Center, 120-1, Neungdong-ro, Gwangjin-gu, Seoul, 05030, South Korea.

Purpose: To evaluate the mid-term outcomes of anatomic medial complex reconstruction in cases of serious medial knee instability.

Methods: Between 2010 and 2013, 23 patients who underwent anatomic medial complex reconstruction with a minimum 5-year follow-up were included. The Lysholm score, International Knee Documentation Committee subjective knee form (IKDC SKF), and Tegner activity scale scores were evaluated. Read More

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http://dx.doi.org/10.1007/s00167-019-05367-9DOI Listing

Age and sex have no impact on expression levels of markers of immune cell infiltration and immune checkpoint pathways in patients with muscle-invasive urothelial carcinoma of the bladder treated with radical cystectomy.

Cancer Immunol Immunother 2019 Apr 17. Epub 2019 Apr 17.

Department of Surgery, Division of Urology, Southern Illinois University School of Medicine, Springfield, IL, USA.

Objectives: Advanced age and female sex have been associated with worse outcomes in patients undergoing radical cystectomy for muscle-invasive bladder cancer. A reduced immune response has been implicated as a mechanism. The objective of our study was to analyze the expression patterns of various cellular proteins active in bladder cancer immune pathways, and assess the correlation between age, sex, and the expression of these immune markers. Read More

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http://link.springer.com/10.1007/s00262-019-02340-w
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http://dx.doi.org/10.1007/s00262-019-02340-wDOI Listing
April 2019
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Electrophysiologic evaluation of facial nerve functions after oxaliplatin treatment.

Cancer Chemother Pharmacol 2019 Apr 17. Epub 2019 Apr 17.

Department of Audiology, Faculty of Health Sciences, Medipol University, Istanbul, Turkey.

Purpose: This study analyzes the effect of oxaliplatin treatment on the facial nerve. The facial nerve is the most commonly paralyzed cranial motor nerve because it advances through a long, curved bone canal. Electroneurography and blink reflex are the electrophysiological measurements used for evaluating facial nerve function. Read More

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http://dx.doi.org/10.1007/s00280-019-03841-2DOI Listing
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