1,054,617 results match your criteria Muscle & nerve[Journal]


Multisite measurement of regional oxygen saturation in Fontan patients with or without protein-losing enteropathy at rest and during exercise.

Pediatr Res 2019 Feb 22. Epub 2019 Feb 22.

Department of Pediatric Cardiology, University of Erlangen-Nuernberg, Loschgestraße 15, 91054, Erlangen, Germany.

Background: Protein-losing enteropathy (PLE) is a severe complication of Fontan circulation with increased risk of end-organ dysfunction. We evaluated tissue oxygenation via near-infrared spectroscopy (NIRS) at different exercise levels in Fontan patients.

Materials And Methods: Assessment of multisite NIRS during cycle ergometer exercise and daily activities in three groups: Fontan patients with PLE; without PLE; patients with dextro-transposition of the great arteries (d-TGA); comparing univentricular with biventricular circulation and Fontan with/without PLE. Read More

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http://dx.doi.org/10.1038/s41390-019-0346-3DOI Listing
February 2019

Varied effects of dietary carotenoid supplementation on oxidative damage in tissues of two waterfowl species.

Comp Biochem Physiol B Biochem Mol Biol 2019 Feb 19. Epub 2019 Feb 19.

College of Health Solutions, Arizona State University, Phoenix, AZ, United States of America; School of Life Sciences, Arizona State University, Tempe, AZ, United States of America. Electronic address:

Carotenoids are regarded as a cornerstone of avian vitality and coloration. Currently, the antioxidant potential of dietary carotenoids is debated for birds. Although some studies support a protective role, others report either no effect or pro-oxidant effects. Read More

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http://dx.doi.org/10.1016/j.cbpb.2019.02.003DOI Listing
February 2019

Common pathogenic mechanism in patients with dropped head syndrome caused by different mutations in the MYH7 gene.

Gene 2019 Feb 19. Epub 2019 Feb 19.

Medical Genetics Laboratory, Petrovsky Russian Research Center of Surgery, Moscow 119991, Russia; Pirogov Russian National Research Medical University, Moscow 117997, Russia.

Mutations in the MYH7 gene are the source of an allelic series of diseases, including various cardiomyopathies and skeletal myopathies that usually manifest in adulthood. We observed a 1.5 y. Read More

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http://dx.doi.org/10.1016/j.gene.2019.02.011DOI Listing
February 2019

Moderate running exercise prevents excessive immune system activation.

Physiol Behav 2019 Feb 19. Epub 2019 Feb 19.

Departamento de Bioquímica, Centro de Ciências Biológicas, Universidade Federal de Santa Catarina, Florianópolis, Brazil. Electronic address:

Benefits of exercise have been documented for many diseases with a chronic progression, including obesity, diabetes mellitus, cardiovascular diseases, neurodegenerative diseases, certain types of cancers, and overall mortality. Low-grade systemic inflammation is a key component of these pathologies and it has been demonstrated that can be prevented by performing regularly physical exercise. The aim of this study was to examine the effect of lipopolysaccharide (LPS)-induced inflammation on glucose and insulin tolerance, exercise performance, production of urinary neopterin and striatal neurotransmitters levels in adult male C57BL/6 mice. Read More

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http://dx.doi.org/10.1016/j.physbeh.2019.02.023DOI Listing
February 2019

Psychophysiological and performance-related responses of a potentiation activity in swimmers of different competitive levels.

Physiol Behav 2019 Feb 19. Epub 2019 Feb 19.

Faculty of Physical Education & Sport Sciences, School of Physical Education & Sport Sciences, Aristotle University of Thessaloniki, Thessaloniki, Greece.

Athletes' competitive level has an effect on several psychophysiological parameters during the execution of sports-related tasks. This study analyzed the acute effect of a potentiation activity (PAP), composed by 5 loaded box jumps, on specific psychological, physiological and performance-related parameters in 22 trained (COM) and untrained (UNT) adult male swimmers. A control condition was also evaluated. Read More

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http://dx.doi.org/10.1016/j.physbeh.2019.02.018DOI Listing
February 2019

Cerebellar transcranial direct current stimulation modulates the effect of cerebellar transcranial magnetic stimulation on the excitability of spinal reflex.

Neurosci Res 2019 Feb 19. Epub 2019 Feb 19.

Faculty of Health Science, Kio University, 4-2-2 Umami-naka, Koryo-cho, Kitakatsuragi-gun, Nara 635-0832, Japan; Neurorehabilitation Research Center of Kio University, Koryo-cho, Kitakatsuragi-gun, Nara 635-0832, Japan. Electronic address:

Cerebellar transcranial magnetic stimulation (C-TMS) facilitates the ipsilateral soleus H-reflex, which reflects the excitability of the spinal motoneuron pool. This study aimed to investigate whether this facilitation of the spinal motoneuron pool excitability by C-TMS is affected by cerebellar transcranial direct current stimulation (ctDCS) in a polarity-specific manner. Eleven healthy adults participated in this study. Read More

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http://dx.doi.org/10.1016/j.neures.2019.01.012DOI Listing
February 2019

Maxillofacial Implications of Scleroderma and Systemic Sclerosis: A Case Report and Literature Review.

J Oral Maxillofac Surg 2019 Jan 28. Epub 2019 Jan 28.

Assistant Professor and Associate Program Director, Department of Oral and Maxillofacial Surgery, University of Rochester Medical Center, Eastman Institute for Oral Health, Rochester, NY.

Scleroderma and more generally systemic sclerosis comprise a group of autoimmune diseases characterized by increased collagen synthesis and deposition within connective tissue. The Scleroderma Foundation estimates that as many as 300,000 persons in the United States have scleroderma. Although the etiology of the disease is unknown, it is thought to be related to chronic inflammation secondary to autoimmune tissue damage. Read More

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http://dx.doi.org/10.1016/j.joms.2019.01.027DOI Listing
January 2019

The metabolic abnormalities of chronic high dose glucocorticoids are not mediated by hypothalamic AgRP in male mice.

Endocrinology 2019 Feb 22. Epub 2019 Feb 22.

Division of Diabetes, Endocrinology and Gastroenterology, Faculty of Biology, Medicine and Health, University of Manchester, Manchester Academic Health Sciences Centre, Manchester, UK.

Glucocorticoids (Gcs) are potent and widely used medicines, but often cause metabolic side effects. A murine model of corticosterone (Cort) treatment results in increased hypothalamic expression of the melanocortin antagonist AgRP in parallel with obesity and hyperglycaemia. This study investigates how these adverse effects develop over time with particular emphasis on hypothalamic involvement. Read More

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http://dx.doi.org/10.1210/en.2019-00018DOI Listing
February 2019

Antibiotic treatment-induced dysbiosis differently affects BDNF and TrkB expression in the brain and in the gut of juvenile mice.

PLoS One 2019 22;14(2):e0212856. Epub 2019 Feb 22.

Department of Medicine and Surgery, University of Insubria, Varese, Italy.

Antibiotic use during adolescence may result in dysbiosis-induced neuronal vulnerability both in the enteric nervous system (ENS) and central nervous system (CNS) contributing to the onset of chronic gastrointestinal disorders, such as irritable bowel syndrome (IBS), showing significant psychiatric comorbidity. Intestinal microbiota alterations during adolescence influence the expression of molecular factors involved in neuronal development in both the ENS and CNS. In this study, we have evaluated the expression of brain-derived neurotrophic factor (BDNF) and its high-affinity receptor tropomyosin-related kinase B (TrkB) in juvenile mice ENS and CNS, after a 2-week antibiotic (ABX) treatment. Read More

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http://journals.plos.org/plosone/article?id=10.1371/journal.pone.0212856PLOS
February 2019

Supportive hand-holding attenuates pupillary responses to stress in adult couples.

PLoS One 2019 22;14(2):e0212703. Epub 2019 Feb 22.

Department of Psychology, Brigham Young University, Provo, Utah, United States of America.

Background: Social relationships, particularly marriage, have been shown to ameliorate the potentially pathogenic impact of stressful events but prior research has been mostly aimed at downstream effects, with less research on real-time reactivity. Pupillometry is an innovative procedure that allows us to see the effects of acute stress in real time. The muscles that control pupil size are linked to the autonomic nervous system, so that when stressed, the pupils dilate; this occurs within 200ms. Read More

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http://journals.plos.org/plosone/article?id=10.1371/journal.pone.0212703PLOS
February 2019

When do anorexic patients perceive their body as too fat? Aggravating and ameliorating factors.

PLoS One 2019 22;14(2):e0212612. Epub 2019 Feb 22.

Institute of Psychology, University of Osnabrück, Osnabrück, Germany.

Objective: Our study investigated body image representations in female patients with anorexia nervosa and healthy controls using a size estimation with pictures of their own body. We also explored a method to reduce body image distortions through right hemispheric activation.

Method: Pictures of participants' own bodies were shown on the left or right visual fields for 130 ms after presentation of neutral, positive, or negative word primes, which could be self-relevant or not, with the task of classifying the picture as "thinner than", "equal to", or "fatter than" one's own body. Read More

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http://journals.plos.org/plosone/article?id=10.1371/journal.pone.0212612PLOS
February 2019

Automatic classification of tissues on pelvic MRI based on relaxation times and support vector machine.

PLoS One 2019 22;14(2):e0211944. Epub 2019 Feb 22.

Le2i, Université Bourgogne Franche-Comte, Dijon, France.

Tissue segmentation and classification in MRI is a challenging task due to a lack of signal intensity standardization. MRI signal is dependent on the acquisition protocol, the coil profile, the scanner type, etc. While we can compute quantitative physical tissue properties independent of the hardware and the sequence parameters, it is still difficult to leverage these physical properties to segment and classify pelvic tissues. Read More

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http://journals.plos.org/plosone/article?id=10.1371/journal.pone.0211944PLOS
February 2019

Mechanical complications in patients with ST-segment elevation myocardial infarction: A single centre experience.

PLoS One 2019 22;14(2):e0209502. Epub 2019 Feb 22.

Department of Cardiology, Swiss Cardiovascular Center, University Hospital Bern, Bern, Switzerland.

Background: The study aims to assess characteristics and outcomes of patients suffering a mechanical complication (MC) after ST-segment elevation myocardial infarction (STEMI) in a contemporary cohort of patients in the percutaneous coronary intervention era.

Methods And Results: This retrospective single-center cohort study encompasses 2508 patients admitted with STEMI between March 9, 2009 and June 30, 2014. A total of 26 patients (1. Read More

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http://journals.plos.org/plosone/article?id=10.1371/journal.pone.0209502PLOS
February 2019

FMG vs EMG: A Comparison of Usability for Real-time Pattern Recognition Based Control.

IEEE Trans Biomed Eng 2019 Feb 19. Epub 2019 Feb 19.

Force Myography (FMG), which measures the surface pressure profile exerted by contracting muscles, has been proposed as an alternative to electromyography (EMG) for human-machine interfaces. Although FMG pattern recognition-based control systems have yielded higher offline classification accuracy, but comparatively few works have examined the usability of FMG for real-time control. In this work, we conduct a comprehensive comparison of EMG and FMG-based schemes using both classification and regression controllers. Read More

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http://dx.doi.org/10.1109/TBME.2019.2900415DOI Listing
February 2019

The First Case Report of Schnitzler Syndrome Presenting with Eye Pain.

Ocul Immunol Inflamm 2019 Feb 22:1-3. Epub 2019 Feb 22.

c Save Sight Institute , University of Sydney , Sydney , NSW , Australia.

Schnitzler syndrome is a rare, auto inflammatory condition known to manifest with bone pain, urticarial rash, fevers, relapsing arthralgia, and fatigue. In this case report, we describe a patient who was diagnosed with Schnitzler Syndrome that had initially presented with a unilateral pressure-type headache with a sensation of a 'dagger' stabbing into the back of the eye. He also had an associated ipsilateral redness of the conjunctiva, eyelid swelling, subtle optic disc elevations bilaterally and facial flushing - but with no visual acuity, pupillary, or lacrimatory changes. Read More

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http://dx.doi.org/10.1080/09273948.2018.1563704DOI Listing
February 2019

Application of the Mechanical High-Pressure Method Combined with High-Performance Liquid Chromatography-Tandem Mass Spectrometry for Determination of Veterinary Drug Residues in Incurred Chicken and Rabbit Muscle Tissues.

J Food Prot 2019 Feb 21:415-421. Epub 2019 Feb 21.

4 Chemistry and Chemical Engineering, Henan Institute of Science and Technology, Hualan Road, Xinxiang 453003, People's Republic of China.

Rapid sample preparation is a key step in the field of food safety. A mechanical high-pressure method using a laboratory-made meat press machine was first introduced in this study to process the incurred muscle samples of chicken and rabbit. By applying high pressure to animal muscle, the meat juice was obtained. Read More

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http://dx.doi.org/10.4315/0362-028X.JFP-18-386DOI Listing
February 2019

Commercially Available Friction-Reducing Patient-Transfer Devices Reduce Biomechanical Stresses on Caregivers' Upper Extremities and Low Back.

Hum Factors 2019 Feb 22:18720819827208. Epub 2019 Feb 22.

Oregon State University, Corvallis, USA.

Objective:: The aim of this study was to evaluate the efficacy of commercially available friction-reducing patient-transfer devices in reducing biomechanical stresses on caregivers and patients.

Background:: Caregivers suffer from high prevalence of work-related musculoskeletal disorders, which is associated with manual patient handling. However, there is not enough information available on the efficacy of various friction-reducing devices in reducing biomechanical stresses in the upper extremities and low back. Read More

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http://dx.doi.org/10.1177/0018720819827208DOI Listing
February 2019

Treatment with EUK-134 improves sarcoplasmic reticulum Ca release but not myofibrillar Ca sensitivity after fatiguing contraction of rat fast-twitch muscle.

Am J Physiol Regul Integr Comp Physiol 2019 Feb 22. Epub 2019 Feb 22.

Graduate School of Integrated Arts and Sciences, Hiroshima University, Japan.

Skeletal muscles undergoing vigorous activity can enter a state of prolonged low-frequency force depression (PLFFD). This study was conducted to examine whether antioxidant treatment is capable of accelerating the recovery from PLFFD with a focus on the function of the sarcoplasmic reticulum (SR) and myofibril. One hour before fatiguing stimulation (FS), rats received an intraperitoneal injection of Eukarion (EUK-134) that mimics the activities of superoxide dismutase and catalase. Read More

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http://dx.doi.org/10.1152/ajpregu.00387.2018DOI Listing
February 2019

Genome-wide effect of pulmonary airway epithelial cell-specific Bmal1 deletion.

FASEB J 2019 Feb 22:fj201801682R. Epub 2019 Feb 22.

Centre for Biological Timing, Faculty of Biology, Health and Medicine, University of Manchester, Manchester, United Kingdom.

Pulmonary airway epithelial cells (AECs) form a critical interface between host and environment. We investigated the role of the circadian clock using mice bearing targeted deletion of the circadian gene brain and muscle ARNT-like 1 ( Bmal1) in AECs. Pulmonary neutrophil infiltration, biomechanical function, and responses to influenza infection were all disrupted. Read More

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http://dx.doi.org/10.1096/fj.201801682RDOI Listing
February 2019

Relation between resting sympathetic outflow & vasoconstrictor responses to sympathetic nerve bursts: sex differences in healthy young adults.

Am J Physiol Regul Integr Comp Physiol 2019 Feb 22. Epub 2019 Feb 22.

Department of Kinesiology and Applied Physiology, University of Delaware, United States.

Previous studies have demonstrated an inverse relation between resting muscle sympathetic nerve activity (MSNA) and vasoconstrictor responsiveness (i.e., sympathetic transduction), such that those with high resting MSNA have low vascular responsiveness and vice-versa. Read More

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http://dx.doi.org/10.1152/ajpregu.00305.2018DOI Listing
February 2019

Maintenance of skeletal muscle function following reduced daily physical activity in healthy older adults: a pilot trial.

Appl Physiol Nutr Metab 2019 Feb 22. Epub 2019 Feb 22.

McMaster University , Kinesiology - Exercise Metabolism Research Group , Hamilton, Ontario, Canada , L8S 4K1 ;

Introduction: Older adults can experience periods of inactivity related to disease or illness, which can hasten the development of physical disability, in part, through reductions in skeletal muscle strength and power. To date no study has characterized adaptations in skeletal muscle physical function in response to reduced daily physical activity.

Methods: Participants (15 men, 69±2 years, 15 women, 68±4 years) restricted their daily steps (<750steps/d, SR) while being energy restricted (ER, -500kcal/d) for 2wks before returning to normal activity levels during recovery (RC, 1wk). Read More

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http://dx.doi.org/10.1139/apnm-2018-0631DOI Listing
February 2019

Cachexia and advanced dementia.

J Cachexia Sarcopenia Muscle 2019 Feb 22. Epub 2019 Feb 22.

Department of Internal Medicine and Medical Specialties (DIMI), Section of Geriatrics, University of Genoa, Genoa, Italy.

Cachexia is a complex metabolic process that is associated with several end-stage organ diseases. It is known to be also associated with advanced dementia, although the pathophysiologic mechanisms are still largely unknown. The present narrative review is aimed at presenting recent insights concerning the pathophysiology of weight loss and wasting syndrome in dementia, the putative mechanisms involved in the dysregulation of energy balance, and the interplay among the chronic clinical conditions of sarcopenia, malnutrition, and frailty in the elderly. Read More

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http://dx.doi.org/10.1002/jcsm.12380DOI Listing
February 2019

Evaluation of the directional relationship between handgrip strength and cognitive function: the Korean Longitudinal Study of Ageing.

Age Ageing 2019 Feb 22. Epub 2019 Feb 22.

Department of Biostatistics, Graduate School of Public Health, Yonsei University, Seoul, Korea.

Background: recent studies suggest that handgrip strength is linked with cognitive impairment at older ages. However, it remains unclear as to whether muscular strength influences subsequent cognitive performance, or whether lower levels of cognitive function increase the likelihood of muscle strength decline.

Objective: to investigate the directional relationship between handgrip strength and cognitive impairment using longitudinal data among older adults. Read More

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http://dx.doi.org/10.1093/ageing/afz013DOI Listing
February 2019

Cooperative effects of sequential PGF2α and IL-1β on IL-6 and COX-2 expression in human myometrial cells.

Biol Reprod 2019 Feb 22. Epub 2019 Feb 22.

Department of Physiology, University of Alberta, Edmonton, Alberta, Canada.

Complex cellular and physiological interactions are required to prepare the uterus for birth. The change from the state of pregnancy to the state of parturition, which we call uterine transitioning, requires the actions of inflammatory mediators and results in an activated uterus capable of performing the physiology of labor. Interleukin (IL)-1β and prostaglandin (PG)F2α are two key mediators implicated in preparing the uterus for labor by regulating the expression of uterine activation proteins (UAPs) and pro-inflammatory cytokines and chemokines. Read More

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http://dx.doi.org/10.1093/biolre/ioz029DOI Listing
February 2019

Connective Tissue Graft Stabilization by Subperiosteal Sling Suture for Periodontal Plastic Surgery Using the VISTA Approach.

Authors:
Jonathan H Do

Int J Periodontics Restorative Dent 2019 Mar/Apr;39(2):253-158

This report describes a minimally invasive surgical approach using the vestibular incision subperiosteal tunnel access and a suture called the subperiosteal sling (SPS) to stabilize the connective tissue graft (CTG) for periodontal plastic surgery. The SPS suture engages only the CTG and stabilizes the CTG against the tooth independent of the overlying tissue, which minimizes the risk of graft mobility caused by muscle movement. Read More

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http://dx.doi.org/10.11607/prd.3529DOI Listing
February 2019

What Is the Success of Repeat Surgical Treatment of a Local Recurrence After Initial Wide Resection of Soft Tissue Sarcomas?

Clin Orthop Relat Res 2018 Sep;476(9):1791-1800

H. Sugiura, Department of Physical Therapy, Nagoya University Graduate School of Medicine, Nagoya, Japan H. Sugiura, S. Tsukushi, M. Yoshida, Department of Orthopaedic Surgery, Aichi Cancer Center Hospital, Nagoya City, Japan Y. Nishida, Department of Orthopaedic Surgery, Nagoya University Graduate School of Medicine, Nagoya, Japan.

Background: Treatment for patients with locally recurrent soft tissue sarcomas after wide resection is challenging, and few studies have examined the results of treating these patients. In treatment of recurrent tumors, it has been reported that positive margins are correlated to local rerecurrence, but the relationship between surgical margin and survival remains controversial and risk factors for local recurrences after wide resection of soft tissue sarcomas are not well established. This study examined clinical outcomes and factors associated with survival and local rerecurrence in patients with local recurrence after initial surgical treatment who underwent another resection with a goal of negative margins. Read More

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http://dx.doi.org/10.1007/s11999.0000000000000158DOI Listing
September 2018

An Early Disc Herniation Identification System for Advancement in the Standard Medical Screening Procedure based on Bayes Theorem.

IEEE J Biomed Health Inform 2019 Feb 15. Epub 2019 Feb 15.

The aim of this research was to analyze objectively the process of disc herniation identification using Bayes Theorem. One of the symptoms of discus hernia is muscle weakness on the foot that is caused by displaced discs in the space of two vertebrae. This fact is used by experts in initial diagnosis of herniated discs and we used it to create non-invasive platform for the same purposes by measuring force values from four sensors placed on both feet (first, second and fourth metatarsal head as well as the heel). Read More

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http://dx.doi.org/10.1109/JBHI.2019.2899665DOI Listing
February 2019

Automatic Muscle Fiber Orientation Tracking in Ultrasound Images Using a New Adaptive Fading Bayesian Kalman Smoother.

IEEE Trans Image Process 2019 Feb 18. Epub 2019 Feb 18.

This paper proposes a new algorithm for automatic estimation of muscle fiber orientation (MFO) in musculoskeletal ultrasound images, which is commonly used for both diagnosis and rehabilitation assessment of patients. The algorithm is based on a novel adaptive fading Bayesian Kalman filter (AF-BKF) and an automatic region of interest (ROI) extraction method. The ROI is firstly enhanced by the Gabor filter (GF) and extracted automatically using the revoting constrained Radon transform (RCRT) approach. Read More

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http://dx.doi.org/10.1109/TIP.2019.2899941DOI Listing
February 2019

Panton-Valentine leucocidin is the key determinant of pyomyositis in a bacterial GWAS.

Elife 2019 Feb 22;8. Epub 2019 Feb 22.

Centre for Tropical Medicine and Global Health, University of Oxford, Oxford, United Kingdom.

Pyomyositis is a severe bacterial infection of skeletal muscle, commonly affecting children in tropical regions, predominantly caused by . To understand the contribution of bacterial genomic factors to pyomyositis, we conducted a genome-wide association study of cultured from 101 children with pyomyositis and 417 children with asymptomatic nasal carriage attending the Angkor Hospital for Children, Cambodia. We found a strong relationship between bacterial genetic variation and pyomyositis, with estimated heritability 63. Read More

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http://dx.doi.org/10.7554/eLife.42486DOI Listing
February 2019

Performance Differences between National Football League and High School American Football Combine Participants.

Res Q Exerc Sport 2019 Feb 22:1-7. Epub 2019 Feb 22.

a University of Nebraska-Lincoln.

Purpose: The purpose of this study was to determine magnitudes of differences for anthropometric and athletic performance scores between high school and elite college-level American football players.

Method: Participants included high school-age (n = 3,666) athletes who participated in American football combines, as well as elite college-level (n = 5,537) athletes who participated in the National Football League (NFL) scouting combine. Combine data included position; height; weight; 10-, 20-, and 40-yard dash; pro-agility (PA); L-cone drill (LC); vertical jump (VJ); and broad jump (BJ). Read More

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http://dx.doi.org/10.1080/02701367.2019.1571679DOI Listing
February 2019

Low-Dose Testosterone and Evoked Resistance Exercise after Spinal Cord Injury [TEREX-SCI] on Cardio-metabolic Risk Factors: An open-label randomized clinical trial.

J Neurotrauma 2019 Feb 22. Epub 2019 Feb 22.

McGuire VA Medical Center, Endocrinology & Metabolism, Richmond, Virginia, United States ;

The purpose of the work is to investigate the effects of low-dose testosterone replacement therapy (TRT) and evoked resistance training (RT) on body composition and metabolic variables after SCI. Twenty-two individuals with chronic motor complete SCI (ages 18-50 years) were randomly assigned to either TRT+RT (n = 11) or TRT (n = 11) for 16 weeks following a 4 -week delayed entry period. TRT+RT men underwent twice weekly progressive RT using electrical stimulation with ankle weights. Read More

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http://dx.doi.org/10.1089/neu.2018.6136DOI Listing
February 2019

Effect of Bilateral and Unilateral Plantarflexor Muscle Fatigue on Blind Navigation Precision and Gait Parameters.

J Mot Behav 2019 Feb 22:1-9. Epub 2019 Feb 22.

a Faculty of Health Sciences, School of Human Kinetics , University of Ottawa , Ottawa , ON , Canada .

The objective was to evaluate the impact of bilateral and unilateral fatigue of the plantarflexor muscles on blind navigation. Thirty-eight young adults walked 8-m without vision before fatigue (pre-fatigue), then fatigued either one or both of their plantarflexor muscles by performing isometric contractions. After each fatigue, two blind navigation trials were performed (post-fatigue trials 1 and 2). Read More

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http://dx.doi.org/10.1080/00222895.2019.1576157DOI Listing
February 2019

LINGO-1 shRNA loaded by Pluronic F-127 promotes functional recovery after ventral root avulsion.

Tissue Eng Part A 2019 Feb 22. Epub 2019 Feb 22.

Dongguan, China ;

Spinal root avulsion typically leads to massive motoneuron death and severe functional deficits of the target muscles. Multiple pathological factors such as severe neuron loss, induction of inhibitory molecules, and insufficient regeneration are responsible for the poor functional recovery. LINGO-1, a CNS-specific transmembrane protein that is selectively expressed on neurons and oligodendrocytes, serves as a potent negative mediator of axonal regeneration and myelination in CNS injuries and diseases. Read More

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http://dx.doi.org/10.1089/ten.TEA.2018.0282DOI Listing
February 2019

Evaluation of the predictive performance of physiologically based pharmacokinetic models for intramuscular injections of therapeutic proteins.

Xenobiotica 2019 Feb 22:1-11. Epub 2019 Feb 22.

a Faculty of Pharmaceutical Sciences , The University of British Columbia , Vancouver , BC , Canada.

Several physiologically-based pharmacokinetic (PBPK) models have been reported for intravenous (IV) and subcutaneous (SC) injections, but there has been a paucity of work for intramuscular (IM) injections. The primary objective of this work was a wide-scale evaluation of the predictive performance of IM PBPK models of therapeutic proteins. PBPK models for all administration routes available in the literature have regarded muscle as the total muscle (TM) in the body; however, anatomically, the body is composed of discrete muscle groups. Read More

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http://dx.doi.org/10.1080/00498254.2019.1571651DOI Listing
February 2019

New human chromosomal sites with 'safe harbor' potential for targeted transgene insertion.

Hum Gene Ther 2019 Feb 22. Epub 2019 Feb 22.

University of Washington, Departments of Pathology & Genome Sciences , Box 357705 , 1959 N.E. Pacific Street Room K072C , Seattle, Washington, United States , 98195-7705 ;

We have identified 35 new sites for targeted transgene insertion that have the potential to serve as new human genomic 'safe harbor' sites. 'Safe harbor' site potential for these 35 sites, located on 16 chromosomes including both arms of the human X chromosome, and for the existing human 'safe harbor' sites AAVS1, hROSA26 and CCR5 was assessed using 8 different desirable, widely accepted criteria for 'safe harbor' sites verifiable with human genomic data. Three representative newly identified sites on human chromosomes 2 and 4 were then experimentally validated by in vitro and in vivo cleavage-sensitivity tests, and analyzed for population-level and cell line-specific sequence variants that might confound site targeting. Read More

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http://dx.doi.org/10.1089/hum.2018.169DOI Listing
February 2019

Oligonol Alleviates Sarcopenia by Regulation of Signaling Pathways Involved in Protein Turnover and Mitochondrial Quality.

Mol Nutr Food Res 2019 Feb 22:e1801102. Epub 2019 Feb 22.

Y.-C. Chang, W.-T. Tseng, H.-L. Wu, S.-J. Chang, Department of Life Sciences, National Cheng Kung University, Tainan, Taiwan.

Scope: Oligonol has been shown to moderate mitochondrial biogenesis, protein synthesis and protein degradation in diabetic mice in our previous study. We therefore hypothesized that oligonol alleviated sarcopenia by regulating pathways involved in protein turnover and mitochondrial quality.

Methods And Results: The 32-wk. Read More

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http://dx.doi.org/10.1002/mnfr.201801102DOI Listing
February 2019

Relationship between the Kihon Checklist and the clinical parameters in patients who participated in cardiac rehabilitation.

Geriatr Gerontol Int 2019 Feb 22. Epub 2019 Feb 22.

Department of Cardiovascular Medicine, Juntendo University Graduate School of Medicine, Tokyo, Japan.

Aim: The Kihon Checklist is a useful screening tool for assessing frailty in older individuals. However, the clinical significance of the Kihon Checklist in cardiac rehabilitation patients remains unclear. The present study aimed to evaluate the relationship between the Kihon Checklist and the clinical parameters in patients who participated in cardiac rehabilitation. Read More

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http://dx.doi.org/10.1111/ggi.13617DOI Listing
February 2019

Prevalence, distribution, and clinical characteristics of hemangiosarcoma-associated skeletal muscle metastases in 61 dogs: A whole body computed tomographic study.

J Vet Intern Med 2019 Feb 22. Epub 2019 Feb 22.

Service of Diagnostic Imaging, I Portoni Rossi Veterinary Hospital, Zola Predosa, Bologna, Italy.

Background: Skeletal muscle metastases (SMMs) have been described sporadically in canine oncology.

Hypothesis/objectives: To determine the prevalence, localization, and clinical signs of SMMs associated with hemangiosarcoma (HSA) in a population of dogs presented for whole body computed tomography (CT).

Animals: Dogs with a histologically confirmed HSA and a tissue core specimen or fine needle aspirate of suspected metastatic lesions were included in the study. Read More

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http://dx.doi.org/10.1111/jvim.15456DOI Listing
February 2019

Modular P wideband inversion transfer for integrative analysis of adenosine triphosphate metabolism, T relaxation and molecular dynamics in skeletal muscle at 7T.

Magn Reson Med 2019 Feb 22. Epub 2019 Feb 22.

Advanced Imaging Research Center, University of Texas Southwestern Medical Center, Dallas, Texas.

Purpose: For efficient and integrative analysis of de novo adenosine triphosphate (ATP) synthesis, creatine-kinase-mediated ATP synthesis, T relaxation time, and ATP molecular motion dynamics in human skeletal muscle at rest.

Methods: Four inversion-transfer modules differing in center inversion frequency were combined to generate amplified magnetization transfer (MT) effects in targeted MT pathways, including Pi ↔ γ-ATP, PCr ↔ γ-ATP, and P ↔ P . MT effects from both forward and reverse exchange kinetic pathways were acquired to reduce potential bias and confounding factors in integrated data analysis. Read More

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http://dx.doi.org/10.1002/mrm.27686DOI Listing
February 2019

Predictors affecting complications and aesthetic outcomes in autologous breast reconstruction with free muscle-sparing transverse rectus abdominis myocutaneous flaps.

Microsurgery 2019 Feb 22. Epub 2019 Feb 22.

Department of Plastic Surgery, Korea University Anam Hospital, Seoul, South Korea.

Background: Identification and understanding of predictors for complications and aesthetic outcomes in free muscle-sparing transverse rectus abdominis myocutaneous (MS-TRAM) flap are essential for successful breast reconstruction. The purpose of this study was to investigate predictors for complications and aesthetic outcomes in patients who underwent autologous breast reconstruction with free MS-TRAM flaps.

Patients And Methods: Between March 2003 and September 2017, a total of 214 patients who underwent breast reconstruction with MS-TRAM flaps were included in this study. Read More

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http://dx.doi.org/10.1002/micr.30442DOI Listing
February 2019

miR-148a-3p regulates proliferation and apoptosis of bovine muscle cells by targeting KLF6.

J Cell Physiol 2019 Feb 22. Epub 2019 Feb 22.

Key Laboratory of Animal Genetics, Breeding and Reproduction of Shaanxi Province, College of Animal Science and Technology, Northwest A&F University, Yangling, Shaanxi, China.

Skeletal muscle development is regulated by a series of regulatory factors, and also including noncoding RNA, especially microRNAs (miRNAs). Recently, miR-148a has been found to be involved in murine C2C12 differentiation by targeting ROCK1. However, the function of miR-148a-3p for the proliferation and apoptosis of bovine muscle cells has not been determined. Read More

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http://dx.doi.org/10.1002/jcp.28232DOI Listing
February 2019

Protein kinase B mediates insulin-like growth factor 1-induced phosphorylation and nuclear export of histone deacetylase 5 via NADPH oxidase 4 activation in vascular smooth muscle cells.

J Cell Physiol 2019 Feb 22. Epub 2019 Feb 22.

Laboratory of Cellular Signaling, Montreal Diabetes Research Center and Centre de Recherche du Centre Hospitalier de l'Université de Montréal (CRCHUM), Montreal, Canada.

Insulin-like growth factor 1 (IGF-1) mediates the generation of reactive oxygen species (ROS) and the activation of growth promoting signaling pathways. Histone deacetylases (HDACs) regulate gene transcription by deacetylating lysine residues in histone and nonhistone proteins and a heightened HDAC activation, notably of HDAC5, is associated with vascular disorders, such as atherosclerosis. Although the contribution of IGF-1 in these pathologies is well documented, its role in HDAC phosphorylation and activation remains unexplored. Read More

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http://dx.doi.org/10.1002/jcp.28353DOI Listing
February 2019

Successful treatment of refractory mechanic's hands with ustekinumab in a patient with the antisynthetase syndrome.

Rheumatology (Oxford) 2019 Feb 21. Epub 2019 Feb 21.

Muscle Disease Unit, National Institute of Arthritis and Musculoskeletal and Skin Diseases, National Institutes of Health, Bethesda, USA.

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http://dx.doi.org/10.1093/rheumatology/kez020DOI Listing
February 2019

Ultrafast yet controllable dual-responsive all-carbon actuator for implementing unusual mechanical movements.

ACS Appl Mater Interfaces 2019 Feb 22. Epub 2019 Feb 22.

Synthetic soft actuators with the integration of fast response speed, large-scale displacement and precise control over deformation direction are highly demanded for implementing agile and precise mechanical movements in smart robots, artificial muscles and biomimetic devices. In this work, ultrafast yet controllable all-carbon actuators are created based on graphene oxide and oriented carbon nanotubes. This all-carbon actuator shows humidity- and near infrared light-induced actuation with unprecedented performance integration, including ultrafast response (0. Read More

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http://dx.doi.org/10.1021/acsami.8b22099DOI Listing
February 2019

[Bronchial thermoplasty in the management of severe asthma : retrospective analysis of 10 cases treated at academic hospital of Liège].

Rev Med Liege 2019 Feb;74(2):74-81

Service de Pneumologie, CHU de Liège, Belgique.

As treating severe forms of asthma represents a medical and economical challenge, research for new therapies in this area is extensive and expansive. Recently, bronchial thermoplasty (BT) - ie. bronchoscopic procedure delivering a thermic form of energy through radiofrequency to the bronchi, in order to interfere with the components of the smooth muscle layer - arose as a promising technique. Read More

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February 2019

Response: Association of Thigh Muscle Mass with Insulin Resistance and Incident Type 2 Diabetes Mellitus in Japanese Americans (Diabetes Metab J 2018;42:488-95).

Diabetes Metab J 2019 Feb;43(1):125-126

Seattle Epidemiologic Research and Information Center, VA Puget Sound Health Care System, Seattle, WA, USA.

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http://dx.doi.org/10.4093/dmj.2019.0028DOI Listing
February 2019

Letter: Association of Thigh Muscle Mass with Insulin Resistance and Incident Type 2 Diabetes Mellitus in Japanese Americans (Diabetes Metab J 2018;42:488-95).

Diabetes Metab J 2019 Feb;43(1):123-124

Department of Internal Medicine, Keimyung University School of Medicine, Daegu, Korea.

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http://dx.doi.org/10.4093/dmj.2019.0026DOI Listing
February 2019

Inclusion of sprints in moderate intensity continuous training leads to muscle oxidative adaptations in trained individuals.

Physiol Rep 2019 Feb;7(4):e13976

Department of Nutrition, Exercise and Sports, University of Copenhagen, Copenhagen, Denmark.

This study examined adaptations in muscle oxidative capacity and exercise performance induced by two work- and duration-matched exercise protocols eliciting different muscle metabolic perturbations in trained individuals. Thirteen male subjects ( O -max 53.5 ± 7. Read More

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http://dx.doi.org/10.14814/phy2.13976DOI Listing
February 2019

Myricanol rescues dexamethasone-induced muscle dysfunction via a sirtuin 1-dependent mechanism.

J Cachexia Sarcopenia Muscle 2019 Feb 21. Epub 2019 Feb 21.

State Key Laboratory of Quality Research in Chinese Medicine, Institute of Chinese Medical Sciences, University of Macau, Avenida da Universidade, Taipa, Macau, China.

Background: Muscle atrophy and weakness are adverse effects of high dose or the sustained usage of glucocorticoids. Loss of mitochondria and degradation of protein are highly correlated with muscle dysfunction. The deacetylase sirtuin 1 (SIRT1) plays a vital role in muscle remodelling. Read More

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http://dx.doi.org/10.1002/jcsm.12393DOI Listing
February 2019

Easy surveillance of muscle volume decline in chronic liver disease patients using finger-circle (yubi-wakka) test.

J Cachexia Sarcopenia Muscle 2019 Feb 21. Epub 2019 Feb 21.

Gastroenterology Center, Ehime Prefectural Central Hospital, 83 Kasuga-cho, Matsuyama, 790-0024, Japan.

Background: Muscle atrophy (MA) and muscle strength decline are important clinical features in chronic liver disease (CLD) patients. An easy to perform MA screening method without need for special equipment would be helpful. We evaluated the usefulness of the previously reported finger-circle test as screening for MA in CLD patients. Read More

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http://dx.doi.org/10.1002/jcsm.12392DOI Listing
February 2019
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