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Hum Vaccin Immunother 2019 Feb 19. Epub 2019 Feb 19.

Health Care Workers (HCWs) have an increased risk of contracting contagious disease, including mumps. In January 2017 the Italian National Vaccine Prevention Plan 2017-2019, recommended the administration of a dose of MMR vaccine (Measles-Mumps-Rubella) to the Health Care Workers (HCWs) that, working in a risky environment, did not carry out the complete vaccination cycle of MMR or that are seronegative for at least one of the three vaccine viruses. In October of the same year, the Advisory Committee on Immunization Practices (ACIP) recommended a third dose of a vaccine containing Mumps Virus for people previously vaccinated with 2 doses, belonging to a group or to a population at increased risk of acquire mumps in the event of an epidemic. Read More

Hum Vaccin Immunother 2019 Feb 19. Epub 2019 Feb 19.

c Department of Epidemiology and Health Statistics , School of Public Health, Anhui Medical University , Hefei , China.

In 2016, an outbreak of mumps occurred in a primary school in China with a student population having high vaccination coverage. An unmatched case-control study was performed to identify risk factors contributing to this outbreak, and a retrospective cohort study was conducted to evaluate the effectiveness of mumps-containing vaccine (MuCV). A total of 97 cases were identified during the outbreak, and the overall attack rate was 8. Read More

Indian Dermatol Online J 2019 Jan-Feb;10(1):19-26

Department of Dermatology, Venereology and Leprosy, Dr. R. P. Govt. Medical College, Kangra (Tanda), Himachal Pradesh, India.

Background: Most therapeutic modalities for common warts remain unsatisfactory.

Objectives: To evaluate efficacy and safety of intralesional MMR (measles, mumps, rubella virus) vaccine in the treatment of common warts in adults.

Patients And Methods: There were 110 (M:F = 61:49) patients aged 19-62 years having 1-211 warts over dorsal hands, feet, palms, soles, and periungual skin for 1-252 months. Read More

Lancet Infect Dis 2019 Feb 11. Epub 2019 Feb 11.

National Centre for Immunisation Research and Surveillance, Westmead, NSW 2145, Australia. Electronic address:

Lancet Infect Dis 2019 Feb 11. Epub 2019 Feb 11.

University of Defence, Faculty of Military Health Sciences, Hradec Kralove, Czech Republic; Charles University, Faculty of Medicine in Hradec Kralove, Department of Social Medicine, Hradec Kralove, Czech Republic.

Background: The duration of protection provided by varicella vaccines is unclear. We assessed the 10-year vaccine efficacy of two doses of a combined measles-mumps-rubella-varicella vaccine (MMRV), one live attenuated varicella vaccine (V) dose given after one measles-mumps-rubella vaccine (MMR) dose (MMR + V), versus two MMR doses (control vaccine) for the prevention of confirmed varicella.

Methods: This was a phase 3b follow-up of an observer-blinded, randomised, controlled trial. Read More

Vaccine 2019 Feb 11. Epub 2019 Feb 11.

Interactive Research School for Health Affairs (IRSHA), Bharati Vidyapeeth (Deemed To Be University), Pune, India. Electronic address:

Background: Immunization of children with vaccines against Measles, Mumps, Rubella, and Varicella (MMRV) is practiced globally with varied recommendations. In India, measles vaccine is administered alone or as MMR at 9 months age. Varicella vaccine is not routinely used. Read More

J Ultrason 2018 ;18(75):359-364

Department of Radiology, University Hospital of Verona, Polo Chirurgico "Confortini" , Verona , Italy.

Swelling of the salivary glands, also known as iodide or iodine mumps, is a rare adverse reaction to administration of iodine, a component steadily present in current contrast media and in a variety of medications. We report and compare with published literature the clinical and sonographic findings in a case of iodide mumps that developed after the intravenous administration of iodine-based contrast media for a contrast-enhanced computed tomography scan. The exact pathogenesis is unknown to date: based on sonographic appearance, we support the hypothesis of an acute inflammatory condition elicited by iodine accumulation in the salivary glands. Read More

Adv Exp Med Biol 2019 Feb 14. Epub 2019 Feb 14.

Department of Pediatrics with Clinical Assessment Unit, Warsaw Medical University, Warsaw, Poland.

A worrying increase in the number of measles cases has been noted recently in Poland, which may have to do with a decreasing proportion of children vaccinated against measles, mumps, and rubella (MMR) in the second year of life (<95%). For many years, MMR vaccination in children has been associated with a fear of allergy to eggs. This study seeks to define the reason and justification for postponing MMR vaccination in a population of children referred to the outpatient specialist immunization clinic. Read More

Euro Surveill 2019 Feb;24(6)

Chief Scientist, Ministry of Health, Jerusalem, Israel.

BackgroundChildhood vaccination schedules recommend vaccine doses at predefined ages.AimWe evaluated vaccination completeness and timeliness in Jerusalem, a district with recurrent vaccine-preventable disease outbreaks.MethodsVaccination coverage was monitored by the up-to-date method (vaccination completeness at age 2 years). Read More

Acta Med Port 2019 Feb 1;32(1):81-85. Epub 2019 Feb 1.

Departamento de Neurologia. Hospital da Luz. Lisboa. Portugal.

Acute disseminated encephalomyelitis is a rare inflammatory demyelinating multifocal disease of the central nervous system that typically occurs in children following vaccination or exanthematous viral infections and conveys an elevated risk of neurological sequelae unless promptly recognized and treated. We describe an adult case of acute disseminated encephalomyelitis following vaccination against Mumps, Measles and Rubella, presenting with fever and progressive neurological deficits which improved under systemic corticosteroid therapy. Considering the ongoing public debate regarding universal vaccination and the surge of previously controlled infectious diseases, we aim not only to underline the need for a rigorous assessment of vaccination safety on adult patients in order to prevent misguidance of public opinion, but also to alert clinicians for an early diagnosis of acute disseminated encephalomyelitis in these patients, the incidence of which we speculate may be rising. Read More

Zhonghua Yu Fang Yi Xue Za Zhi 2019 Feb;53(2):174-178

Division of Expanded Immunization Program, Shandong Center for Disease Control and Prevention; Academy of Preventive Medicine, Shandong University; Shandong Provincial Key Laboratory of Infectious Disease Control and Prevention, Jinan 250014, China.

To characterize the etiology and epidemiological characteristics of the acute meningitis and encephalitis syndrome (AMES) in Jinan city in 2013-2016. The epidemiological data, clinical diagnosis, serum and cerebrospinal fluid (CSF) specimens were collected from 3 577 AMES cases in 6 sentinel hospitals in Jinan city in 2013-2016. Samples of all cases were made sero-diagnosis for Immunoglobulin (Ig) M antibody to Japanese encephalitis virus (JEV) and negative cases of JEV for enterovirus (EV), mumps virus (MuV) and herpes simplex virus (HSV) by enzyme-linked immunosorbent assay (ELISA). Read More

Infect Genet Evol 2019 Feb 7;69:230-234. Epub 2019 Feb 7.

Centre for Immunology of Infectious Diseases and Vaccines, National Institute for Public Health and the Environment (RIVM), Bilthoven, The Netherlands.

Mumps viruses continue to cause sporadic cases and outbreaks in countries with a high vaccination coverage for mumps. Molecular surveillance of mumps viruses can be supportive to elucidate the origin and transmission routes of mumps virus in case of an outbreak. Currently, molecular surveillance is worldwide primarily focused on sequencing of the small hydrophobic (SH) gene. Read More

Hum Vaccin Immunother 2019 Feb 6. Epub 2019 Feb 6.

b Japan Vaccine Co., Ltd .

Domestic measles, mumps, and rubella combined (MMR) vaccines were discontinued in 1993 in Japan because of the unexpected high incidence of aseptic meningitis. The introduction of an effective MMR vaccine with lower reactogenicity has been expected. A new MMR vaccine (JVC-001) was developed, using mumps RIT4385 strain in combination with Japanese measles AIK-C strain and rubella Takahashi strain (MR) vaccine. Read More

J Immunol Res 2019 6;2019:2075803. Epub 2019 Jan 6.

Department of Experimental, Clinical and Preventive Medicine, State Research Institute Centre for Innovative Medicine, Santariskiu St. 5, LT-08406 Vilnius, Lithuania.

Aim: The aim of this study was to evaluate the expression of persistence of mumps virus and some cells that interact with viral infection in the focus of the autoimmune epithelitis and peripheral blood of Sjögren's syndrome patients in comparison to patients with rheumatoid arthritis (RA) and nonautoimmune sicca syndrome (nSS).

Materials And Methods: 126 patients (119 women and 7 men) were grouped into four groups: (1) patients with primary Sjögren's syndrome (pSS), (2) patients with secondary Sjögren's syndrome due to rheumatoid arthritis (sSS), (3) patients with rheumatoid arthritis (RA), and (4) patients with nonautoimmune sicca syndrome (nSS). Immunohistochemical analysis of immune response to the suggested silent persistence of mumps virus in the minor labial salivary gland biopsies and flow cytometric analysis of blood cells was done. Read More

Am J Med Sci 2018 Dec 24. Epub 2018 Dec 24.

Department of Medicine, University of Maryland School of Medicine, Baltimore, Maryland. Electronic address:

Francisco Goya produced over 1,800 works during his long career, which earned him a reputation as one of the greatest artists of modern times. When he was 47, he developed a mysterious illness that destroyed his hearing, and for the next 35 years left him "deaf as a stump." Of the diagnoses proposed to date, Susac syndrome is the one most consistent with what little we do know of the character of that illness. Read More

Viruses 2019 Jan 31;11(2). Epub 2019 Jan 31.

Department of Veterinary and Biomedical Sciences, The Pennsylvania State University, University Park, PA 16802, USA.

To define the links between paramyxovirus budding and cellular ESCRT machinery, we previously identified angiomotin-like 1 (AMOTL1) in a screen for host factors that bind to the matrix (M) protein of parainfluenza virus 5 (PIV5). This protein harbors three L/PPXY sequences, allowing it to interact with WW domain containing proteins including NEDD4 family members. We hypothesize that paramyxoviruses use AMOTL1 as a linker to indirectly recruit the same NEDD4 ubiquitin ligases for budding that other enveloped viruses recruit directly through their PPXY late domains. Read More

Med J Armed Forces India 2019 Jan 18;75(1):70-73. Epub 2019 Jan 18.

Dean and Deputy Commandant, Armed Forces Medical College, Pune 411040, India.

Background: Global elimination of vaccine preventable diseases, such as measles, mumps and rubella is a priority. Many countries have reported diminishing of antibody titres against these diseases among young population as immunization coverage of adolescents and adults in not monitored. The objective of this study was to determine the susceptibility against measles, mumps and rubella among young adults. Read More

Int J Pediatr Otorhinolaryngol 2019 Jan 22;119:118-122. Epub 2019 Jan 22.

Department of Otolaryngology, National Taiwan University Hospital, Taipei, Taiwan. Electronic address:

Objective: This study compared the prevalence of sudden deafness (SD) in children to investigate the evolution of pediatric SD during the past two decades.

Methods: From 1996 to 2005, totaling 358 SD patients were experienced. Of them, 25 patients (7%) aged <15 years were assigned to Group A. Read More

MMWR Morb Mortal Wkly Rep 2019 Feb 1;68(4):95-96. Epub 2019 Feb 1.

BMJ Open 2019 Jan 29;9(1):e025113. Epub 2019 Jan 29.

Medical Directorate, Charité - Universitätsmedizin Berlin, Berlin, Germany.

Introduction: Childhood vaccination programmes have been established in all Organisation for Economic Co-operation and Development (OECD) countries; however, measles, mumps and rubella (MMR) as well as diphtheria, tetanus, pertussis and polio (Tdap-IPV) vaccination rates are not optimal in adolescents. Education in combination with easy access vaccination may be a promising approach to improve vaccination rates. We aim at improving MMR and Tdap-IPV rates in a school setting in the context of a planned cluster randomised controlled trial (cRCT), the present paper describes the detailed protocol of this trial. Read More

Dermatol Online J 2018 Dec 15;24(12). Epub 2018 Dec 15.

Naval Medical Center Camp Lejeune, Camp Lejeune, North Carolina.

Verruca vulgaris is a prevalent childhood condition, but treatments are often poorly tolerated. Early treatment is preferable because delays increase the probability of pain, disfigurement, and failed eradication. However, typical treatments require multiple sessions without promising cure. Read More

BMC Bioinformatics 2019 Jan 23;20(1):48. Epub 2019 Jan 23.

Department of Laboratory Medicine, University of Washington, Seattle, WA, USA.

Background: With sequencing technologies becoming cheaper and easier to use, more groups are able to obtain whole genome sequences of viruses of public health and scientific importance. Submission of genomic data to NCBI GenBank is a requirement prior to publication and plays a critical role in making scientific data publicly available. GenBank currently has automatic prokaryotic and eukaryotic genome annotation pipelines but has no viral annotation pipeline beyond influenza virus. Read More

JMIR Public Health Surveill 2019 Jan 23;5(1):e9544. Epub 2019 Jan 23.

Department of Computer Science, University of Copenhagen, Copenhagen, Denmark.

Background: Understanding the influence of media coverage upon vaccination activity is valuable when designing outreach campaigns to increase vaccination uptake.

Objective: To study the relationship between media coverage and vaccination activity of the measles-mumps-rubella (MMR) vaccine in Denmark.

Methods: We retrieved data on media coverage (1622 articles), vaccination activity (2 million individual registrations), and incidence of measles for the period 1997-2014. Read More

Eur J Gen Pract 2019 Jan 23:1-6. Epub 2019 Jan 23.

a Conseil Scientifique du Collège National des Généralistes Enseignants (CNGE) , Paris , France.

In this opinion paper, the authors argue that the extension of mandatory immunization of infants up to two years of age from three diseases (diphtheria, tetanus, poliomyelitis) to 11 diseases, introduced in France in January 2018, is not a sustainable response to the challenge of controlling vaccine-preventable diseases. In France in 2017, infant immunization coverage (IC) rates were sufficiently high or increasing (hepatitis B), except for measles, mumps and rubella (MMR) and meningococcus C disease. Even if vaccination obligation makes it possible to achieve the MMR IC objectives among infants, communication programmes and supported advice from GPs are essential for the catch-up of susceptible adults to obtain herd immunity. Read More

Iran J Med Sci 2019 Jan;44(1):10-17

General physician, Mazandaran University of Medical Sciences, Sari, Iran.

Background: Common resistant-to-therapy warts pose a challenge to both clinicians and patients. Among many destructive and immunotherapeutic options, no single, fully effective treatment has been suggested yet. Many investigations, including those using intralesional antigen administrations, have demonstrated that cellular immunity plays a major role in the clearance of human papilloma virus (HPV) infection. Read More

J Hum Lact 2019 Jan 18:890334418823539. Epub 2019 Jan 18.

1 National Centre for Disease Prevention and Health Promotion, Italian National Institute of Health, Rome, Italy.

Background: In Italy, there is no widespread standardized national monitoring system for breastfeeding practices.

Research Aims: To estimate breastfeeding indicators according to World Health Organization recommendations and associated socioeconomic factors, highlighting the potential and limitations of vaccination centers as sources of data.

Methods: A cross-sectional study was conducted in the vaccination centers of 13 Local Health Districts in Italy. Read More

Arch Pediatr 2019 Feb 10;26(2):56-64. Epub 2019 Jan 10.

Association française de pédiatrie ambulatoire (AFPA), 78100 Saint-Germain-en-Laye, France; Association Clinique et thérapeutique infantile du Val-de-Marne (ACTIV), 94100 Saint-Maur-des-Fossés, France; Service de néonatologie, unité Court Séjour, Petits Nourrissons, centre hospitalier Intercommunal de Créteil, 94010 Créteil France; Université Paris Est, IMRB-GRC GEMINI, 94010 Créteil, France. Electronic address:

Objectives: The vaccine schedule was changed in 2013 in France, which resulted in fewer vaccinations. However, to maintain disease protection, both vaccine timeliness and high coverage should be respected. In the context of growing vaccine hesitancy, we aimed to describe compliance with the immunization program according to the age recommended for each dose for non-preterm children less than 2 years old. Read More

Lancet Infect Dis 2019 Feb 8;19(2):185-192. Epub 2019 Jan 8.

Arkansas Department of Health, Little Rock, AR, USA. Electronic address:

Background: During 2000-15, Arkansas Department of Health, Little Rock, AR, USA, investigated between one and six cases of mumps each year. From Aug 5, 2016, to Aug 5, 2017, the department received notification of more than 4000 suspected mumps cases in the second largest outbreak in the USA in the past 30 years.

Methods: Arkansas Department of Health investigated all reported cases of mumps to ascertain exposure, travel, and vaccination histories and identify close contacts. Read More

Lancet Infect Dis 2019 Feb 8;19(2):119-120. Epub 2019 Jan 8.

Wesfarmer's Centre for Vaccines and Infectious Diseases, Telethon Kids Institute, University of Western Australia, Nedlands, WA 6009, Australia; Department of Infectious Diseases, Perth Children's Hospital, Nedlands WA 6009, Australia.

Int J Environ Res Public Health 2019 Jan 9;16(2). Epub 2019 Jan 9.

Department of Public Health Surveillance & Advisory, Zhejiang Provincial Center for Disease Control and Prevention, 3399 Binsheng Road, Binjiang District, Hangzhou 310051, China.

This study aims to learn the characteristics of morbidity and mortality of notifiable diseases reported in children aged 0⁻14 years in Zhejiang Province in 2008⁻2017. We collated data from the China Information System for Disease Control and Prevention in Zhejiang province between 1 January 2008 and 31 December 2017 of children aged 0⁻14 years. From 2008 to 2017, a total of 32 types and 1,994,740 cases of notifiable diseases were reported in children aged 0⁻14 years, including 266 deaths in Zhejiang Province. Read More

J Virol 2019 Jan 9. Epub 2019 Jan 9.

Centre for Infectious Disease Control, National Institute for Public Health and the Environment, Bilthoven, The Netherlands.

Mumps outbreaks among vaccinated young adults stress the need for a better understanding of the mumps virus (MuV)-induced immunity. Antibody responses to MuV are well-characterized, but studies on T cell responses are limited. We recently isolated a MuV-specific CD4 T cell clone by stimulating PBMCs of a mumps case with the viral nucleoprotein (MuV-N). Read More

Viruses 2019 Jan 8;11(1). Epub 2019 Jan 8.

Centre for Viral Zoonoses, Department of Medical Virology, School of Medicine, Faculty of Health Sciences, University of Pretoria, Pretoria 0001, South Africa.

The Egyptian rousette bat () has previously been implicated as the natural host of a zoonotic rubulavirus; however, its association with rubulaviruses has been studied to a limited extent. Urine, spleen, and other organs collected from the population within South Africa were tested with a hemi-nested RT-PCR assay targeting a partial polymerase gene region of viruses from the - and genera. Urine was collected over a 14-month period to study the temporal dynamics of viral excretion. Read More

Indian J Sex Transm Dis AIDS 2018 Jul-Dec;39(2):133-135

Department of Dermatology and Venereology, All India Institute of Medical Sciences, Rishikesh, Uttarakhand, India.

Genital warts have a big psychological impact on the affected individuals, as the treatment requires time and multiple sessions at a time. They can also increase the chances of acquiring other sexually transmitted diseases. Various treatment options are available including the topical application of imiquimod, podophyllin, trichloroacetic acid application, cryotherapy, and radiofrequency cautery. Read More

Klin Padiatr 2019 Jan 2. Epub 2019 Jan 2.

Pediatric Hematology and Oncology, University of Frankfurt, Frankfurt, Germany.

Background: Due to the potential loss of protective antibody titers after autologous hematopoietic stem cell transplantation (HSCT), revaccination is important. The aim of the study was to evaluate the current strategies in Germany, Austria and Switzerland for revaccination of children after autologous HSCT.

Methods: An internet-based survey was performed, and results were analyzed in a descriptive way. Read More

BMJ Case Rep 2018 Dec 27;11(1). Epub 2018 Dec 27.

Department of Virology, Post Graduate Institute of Medical Education and Research, Chandigarh, India.

Acute disseminated encephalomyelitis (ADEM) is a rare inflammatory-demyelinating disease of central nervous system. Several viral infections and vaccines act as precipitating factor for ADEM. We report an 8-year-old girl presenting with acute-onset flaccid paraparesis and bilateral painless vision loss. Read More

Expert Rev Vaccines 2019 Jan 26;18(1):75-87. Epub 2018 Dec 26.

a Mayo Clinic Vaccine Research Group , Mayo Clinic , Rochester , MN , USA.

Introduction: Repeated measles outbreaks in countries with relatively high vaccine coverage are mainly due to failure to vaccinate and importation; however, cases in immunized individuals exist raising questions about suboptimal measles vaccine-induced humoral immunity and/or waning immunity in a low measles-exposure environment. Areas covered: The plaque reduction neutralization measurement of functional measles-specific antibodies correlates with protection is the gold standard in measles serology, but it does not assess cellular-immune or other parameters that may be associated with durable and/or protective immunity after vaccination. Additional correlates of protection and long-term immunity and new determinants/signatures of vaccine responsiveness such as specific CD46 and IFI44L genetic variants associated with neutralizing antibody titers after measles vaccination are under investigation. Read More

Med Mal Infect 2018 Dec 21. Epub 2018 Dec 21.

Service des maladies infectieuses et tropicales, Centre de vaccinations internationales et conseils aux voyageurs, CHU de Saint-Étienne, 42055 Saint-Étienne, France; Inserm, CIC 1408, 42055 Saint-Étienne, France; Inserm, F-CRIN, Innovative clinical research network in vaccinology (I-REIVAC), 75679 Paris, France; Groupe immunité des muqueuses et agents Pathogènes - GIMAP EA 3064, université de Saint-Étienne, Université de Lyon, 42270 Saint-Priest-en-Jarez, France.

Background: Travelers may be responsible for the spread of vaccine-preventable diseases upon return. Travel physicians and family physicians may play a role in checking and updating vaccinations before traveling. Our aim was to evaluate the vaccine coverage for mandatory and recommended vaccination in travelers attending a travel medicine clinic (TMC). Read More

SSM Popul Health 2019 Apr 15;7:005-5. Epub 2018 Nov 15.

Institute of Communication and Health, Università della Svizzera italiana, Switzerland.

Switzerland has not yet reached the measles vaccination coverage of 95 percent that is recommended by the World Health Organization to achieve herd immunity. Within the overall objective of informing effective ways to promote the combined Measles, Mumps, Rubella (MMR) vaccination in Switzerland, the aim of this study was to identify predictors of parents' intention to adhere to official MMR vaccination recommendations. Between October 2012 and January 2013, we surveyed 554 parents of middle school students aged 13 to 15 in Ticino, Switzerland. Read More

Medicine (Baltimore) 2018 Dec;97(51):e13526

Department of Traditional Mongolian Medical Intrusive Encephalopathy, Affiliated Hospital of Inner Mongolia University for the Nationalities, Tongliao City, Inner Mongolia Autonomous Region, PR China.

Background: Influenza, measles, and mumps are common viral infectious diseases in Mongolia. The traditional Mongolian medicine (TMM) classified them as warm disease, and still plays a major role in the diagnoses and treatments.

Methods: To interpret the connotation of the complex theoretical system in TMM with scientific technique, in this study, a high throughput mass spectrometry was used to identify potential protein markers of TMM symptom types. Read More

Zhonghua Liu Xing Bing Xue Za Zhi 2018 Dec;39(12):1589-1595

Division of Infectious Disease Control and Prevention, Key Laboratory of Surveillance and Early Warning on Infectious Diseases, Chinese Center for Disease Control and Prevention, Beijing 102206, China.

To analyze the epidemiological characteristics of notifiable infectious diseases among Chinese students from 2011 to 2016 and to provide reference for the effective prevention and control programs on infectious disease among students. Both morbidity and mortality of notifiable infectious diseases among Chinese students aged 6-22 years from 2011 to 2016 were analyzed, with main characteristics of the disease described. During 2011 to 2016, morbidities of Categories A, B and C infectious diseases among the Chinese students aged 6-22 years showed a decreasing trend, from 248. Read More

Andrologia 2018 Dec;50(11):e13140

Institute of Basic Medical Sciences, School of Basic Medicine, Chinese Academy of Medical Sciences, Peking Union Medical College, Beijing, China.

The detrimental effects of Zika virus (ZIKV) infection on mouse testicular functions have reminded a viral threat to male fertility. A broad range of virus families has tropism for male reproductive system, particularly the testes. Certain virus types of these viruses, such as mumps virus and human immunodeficiency virus (HIV), may severely damage the testes and consequently lead to male infertility. Read More

J Virol 2018 Dec 19. Epub 2018 Dec 19.

Wellcome Trust Sanger Institute, Wellcome Trust Genome Campus, Hinxton, CB10 1SA, United Kingdom

The acute anti-viral response is mediated by a family of interferon stimulated genes (ISG), providing cell-intrinsic immunity. Mutations in genes encoding these proteins are often associated with increased susceptibility to viral infections. One family of ISGs with anti-viral function are the interferon-inducible transmembrane proteins (IFITM) of which IFITM3 has been studied extensively. Read More

IEEE J Solid-State Circuits 2018 Jul 27;53(7):2054-2064. Epub 2018 Apr 27.

Electrical and Computer Engineering Department, University of California, San Diego, La Jolla, CA 92093 USA.

High-density biosensor arrays are essential for many cutting-edge biomedical applications including point-of-care vaccination screening to detect multiple highly-contagious diseases. Typical electrochemical biosensing techniques are based on the measurement of sub-pA currents for micron-sized sensors requiring highly-sensitive readout circuits. Such circuits are often too complex to scale down for high-density arrays. Read More

Lancet Infect Dis 2019 Feb 14;19(2):118-119. Epub 2018 Dec 14.

Department of Pediatrics, University of Pennsylvania, Philadelphia, PA, USA; Wistar Institute, Philadelphia, PA, USA; Vaxconsult LLC, Doylestown, PA, USA.

Lancet Infect Dis 2019 Feb 14;19(2):177-184. Epub 2018 Dec 14.

Communicable Disease Control Directorate, Public and Aboriginal Health Division, Western Australia Department of Health, Perth, WA, Australia.

Background: In 2007-08, a genotype J mumps outbreak occurred among Aboriginal people in northern Western Australia, despite high vaccine coverage. In March, 2015, a second protracted mumps outbreak occurred in northern Western Australia and spread widely across rural areas of the state. This time the outbreak was caused by a genotype G virus and again primarily affected Aboriginal people. Read More

Inflamm Bowel Dis 2018 Dec 14. Epub 2018 Dec 14.

Section of Paediatric Gastroenterology, Department of Paediatrics, University of Calgary, Calgary, Alberta, Canada.

Background: Data on the serologic status of childhood vaccines, cytomegalovirus (CMV) and Epstein-Barr virus (EBV), are limited in inflammatory bowel disease (IBD). Therefore, we evaluated vaccine coverage and seroprotection, along with CMV and EBV seropositivity, in pediatric IBD.

Methods: In a cross-sectional study, demographic data, IBD history, vaccine records, and serum for antibodies against measles, mumps, rubella, diphtheria, tetanus, varicella, hepatitis B (HBV), CMV, and EBV were collected from children with IBD. Read More

J Clin Imaging Sci 2018 15;8:47. Epub 2018 Nov 15.

Department of Imaging Sciences, University of Rochester Medical Center, Rochester, New York, USA.

The major and minor salivary glands of the head and neck are important structures that contribute to many of the normal physiologic processes of the aerodigestive tract. The major salivary glands are routinely included within the field of view of standard neuroimaging, and although easily identifiable, salivary pathology is relatively rare and often easy to overlook. Knowledge of the normal and abnormal imaging appearance of the salivary glands is critical for forming useful differential diagnoses, as well as initiating proper clinical workup for what are often incidental findings. Read More

Viruses 2018 12 8;10(12). Epub 2018 Dec 8.

Institute for Integrative Systems Biology (I2SysBio), Universitat de Valencia-CSIC, 46980 Valencia, Spain.

The order harbors numerous viruses of significant relevance to human health, including both established and emerging infections. Currently, vaccines are only available for a small subset of these viruses, and antiviral therapies remain limited. Being obligate cellular parasites, viruses must utilize the cellular machinery for their replication and spread. Read More

JAMA 2018 Dec;320(22):2304

Med Mal Infect 2019 Feb 4;49(1):38-46. Epub 2018 Dec 4.

Groupe d'études en préventologie (GEP), hôpital d'instruction des armées Robert-Picqué, 351, route de Toulouse, 33140 Villenave-d'Ornon, France.

Objectives: To measure vaccine coverage among adolescents aged 16-18 years who participated in the National Defense Preparation Day in the Aquitaine region using the free electronic immunization record.

Patients And Methods: We considered adolescents aged 16-18 years who participated in the National Defense Preparation Day in the Aquitaine region from April to October 2013. All participants received a letter explaining how to create an electronic immunization record. Read More