10,602 results match your criteria Mumps


Serologic Status of Routine Childhood Vaccines, Cytomegalovirus, and Epstein-Barr Virus in Children With Inflammatory Bowel Disease.

Inflamm Bowel Dis 2018 Dec 14. Epub 2018 Dec 14.

Section of Paediatric Gastroenterology, Department of Paediatrics, University of Calgary, Calgary, Alberta, Canada.

Background: Data on the serologic status of childhood vaccines, cytomegalovirus (CMV) and Epstein-Barr virus (EBV), are limited in inflammatory bowel disease (IBD). Therefore, we evaluated vaccine coverage and seroprotection, along with CMV and EBV seropositivity, in pediatric IBD.

Methods: In a cross-sectional study, demographic data, IBD history, vaccine records, and serum for antibodies against measles, mumps, rubella, diphtheria, tetanus, varicella, hepatitis B (HBV), CMV, and EBV were collected from children with IBD. Read More

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December 2018
1 Read

Review of the Major and Minor Salivary Glands, Part 1: Anatomy, Infectious, and Inflammatory Processes.

J Clin Imaging Sci 2018 15;8:47. Epub 2018 Nov 15.

Department of Imaging Sciences, University of Rochester Medical Center, Rochester, New York, USA.

The major and minor salivary glands of the head and neck are important structures that contribute to many of the normal physiologic processes of the aerodigestive tract. The major salivary glands are routinely included within the field of view of standard neuroimaging, and although easily identifiable, salivary pathology is relatively rare and often easy to overlook. Knowledge of the normal and abnormal imaging appearance of the salivary glands is critical for forming useful differential diagnoses, as well as initiating proper clinical workup for what are often incidental findings. Read More

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November 2018

Chaperoning the : Current Knowledge and Future Directions.

Viruses 2018 Dec 8;10(12). Epub 2018 Dec 8.

Institute for Integrative Systems Biology (I2SysBio), Universitat de Valencia-CSIC, 46980 Valencia, Spain.

The order harbors numerous viruses of significant relevance to human health, including both established and emerging infections. Currently, vaccines are only available for a small subset of these viruses, and antiviral therapies remain limited. Being obligate cellular parasites, viruses must utilize the cellular machinery for their replication and spread. Read More

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December 2018

Mumps Outbreak Near Denver.

Authors:
Bridget Kuehn

JAMA 2018 Dec;320(22):2304

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December 2018

Assessment of vaccination coverage of adolescents aged 16-18 years with an innovative electronic immunization record system.

Med Mal Infect 2018 Dec 4. Epub 2018 Dec 4.

Groupe d'études en préventologie (GEP), hôpital d'instruction des armées Robert-Picqué, 351, route de Toulouse, 33140 Villenave-d'Ornon, France.

Objectives: To measure vaccine coverage among adolescents aged 16-18 years who participated in the National Defense Preparation Day in the Aquitaine region using the free electronic immunization record.

Patients And Methods: We considered adolescents aged 16-18 years who participated in the National Defense Preparation Day in the Aquitaine region from April to October 2013. All participants received a letter explaining how to create an electronic immunization record. Read More

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December 2018

Prevention of Infectious Diseases due to Immunosuppression and Vaccinations in Asian Patients with Inflammatory Bowel Disease.

Inflamm Intest Dis 2018 Nov 17;3(1):1-10. Epub 2018 Jul 17.

Center for Advanced IBD Research and Treatment, Kitasato University Kitasato Institute Hospital, Tokyo, Japan.

Background: Inflammatory bowel disease (IBD) patients with immunocompromise have a high risk of developing complications related to viral infections. Western countries were the first to formulate vaccine guideline. Asian countries developed their national and international vaccine guidelines a little later in order to reduce the risk of mortality from viral infections. Read More

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November 2018
2 Reads

The comparative biochemistry of viruses and humans: an evolutionary path towards autoimmunity.

Authors:
Darja Kanduc

Biol Chem 2018 Dec 3. Epub 2018 Dec 3.

Department of Biosciences, Biotechnologies and Biopharmaceutics, University of Bari, Via Orabona 4, I-70124 Bari, Italy.

Analyses of the peptide sharing between five common human viruses (Borna disease virus, influenza A virus, measles virus, mumps virus and rubella virus) and the human proteome highlight a massive viral vs. human peptide overlap that is mathematically unexpected. Evolutionarily, the data underscore a strict relationship between viruses and the origin of eukaryotic cells. Read More

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December 2018
8 Reads

Causal relationship between immunological responses and adverse reactions following vaccination.

Authors:
Tetsuo Nakayama

Vaccine 2018 Nov 29. Epub 2018 Nov 29.

Kitasato Institute for Life Sciences, Laboratory of Viral Infection, 5-9-1 Shirokane Minato-ku, Tokyo 108-8641, Japan. Electronic address:

Vaccine adverse events and controversial safety issues have occurred in recent decades in Japan: aseptic meningitis following the measles-mumps-rubella combined vaccine (MMR), anaphylaxis after immunization with live virus vaccines and inactivated split influenza vaccine, an increased incidence of febrile illness following the simultaneous administration of inactivated vaccines, and chronic pain with neurological illness after immunization with the human papilloma virus vaccine (HPV). Vaccine adverse events are a matter of concern for the public as well as general practitioners; some are within the range of assumptions that adverse reactions after live attenuated vaccines are related to the nature of their parental wild-type viruses. Vaccines stimulate the innate immunity of host immunological defense mechanisms and induce the development of specific acquired immunity. Read More

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November 2018
1 Read

Sera from different age cohorts in Belgium show limited cross-neutralisation between the mumps vaccine and outbreak strains.

Clin Microbiol Infect 2018 Nov 28. Epub 2018 Nov 28.

Department of Viral Diseases, Sciensano, Brussels, Belgium;. Electronic address:

Objectives: Mumps used to affect children between two and 15 years old. The MMR (mumps-measles-rubella) vaccine is available with vaccine coverage rate of about 85% after two vaccine doses. Recently, new mumps outbreaks emerged in highly vaccinated populations and the causes for these new outbreaks are yet unknown. Read More

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November 2018
1 Read

Dynamic transmission model of routine mumps vaccination in Japan.

Authors:
Taito Kitano

Epidemiol Infect 2018 Dec 3:1-8. Epub 2018 Dec 3.

Department of Neonatal Intensive Care Unit,Nara Prefecture General Medical Center,Nara,Japan.

The mumps vaccine is not included in the national immunisation programme (NIP) of approximately 80 countries including Japan. To investigate the vaccine's cost-effectiveness, we developed a dynamic transmission model for routine one- and two-dose mumps vaccination programs in Japan. We calculated the incremental cost-effectiveness ratio compared with a current programme over a projected 50-year period. Read More

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December 2018

Immunogenicity and safety of intramuscular versus subcutaneous administration of a combined measles, mumps, rubella, and varicella vaccine to children 12 to 18 months of age.

Hum Vaccin Immunother 2018 Nov 27. Epub 2018 Nov 27.

c Sanofi Pasteur MSD , Lyon , France.

This randomized trial conducted in France compared intramuscular (IM) and subcutaneous (SC) administration of two doses of a measles, mumps, rubella, and varicella (MMRV) combination vaccine (ProQuad®) administered one month apart to 405 children 12-18 months of age (NCT00402831). The 2-dose regimen of MMRV administered IM was shown to be as immunogenic as the 2-dose regimen administered SC for all antigens 6 weeks post-vaccination for the subjects who were initially seronegative for measles, mumps, rubella, or varicella (lower bounds of the two-sided 95% CIs for the difference in response rates for all antigens greater than -10% [range -2.1 for varicella to -3. Read More

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November 2018
2 Reads

Similar relative risks of seizures following measles containing vaccination in children born preterm compared to full-term without previous seizures or seizure-related disorders.

Vaccine 2019 Jan 23;37(1):76-79. Epub 2018 Nov 23.

Center for Clinical Epidemiology and Population Health, Marshfield Clinic Research Institute, Marshfield, WI, USA.

Background: Febrile seizures are associated with the first dose of measles-containing vaccines and the risk increases with chronologic age during the second year of life. We used the Vaccine Safety Datalink (VSD) to determine if the relative increase in risk of seizures following receipt of measles-containing vaccine differs by gestational age at birth.

Methods: Children were eligible if they received their first dose of measles-containing vaccine at age 12 through 23 months from January 2003 through September 2015. Read More

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January 2019
5 Reads

Post-exposure prophylaxis for measles with immunoglobulins revised recommendations of the standing committee on vaccination in Germany.

Vaccine 2018 Dec 23;36(52):7916-7922. Epub 2018 Nov 23.

University of Basel Children's Hospital, Spitalstrasse 33, CH-4056 Basel, Switzerland.

Passive immunisation with immunoglobulins as post-exposure prophylaxis after contact with measles is recommended by the German Standing Committee on Vaccination (STIKO) particularly for unprotected individuals at high risk of complications for whom active immunization is contraindicated, such as infants <6 months of age, immunocompromised patients and pregnant women. The efficacy of passive immunisation in preventing measles depends on how soon after exposure it is administered, the concentration of measles antibodies in the immunoglobulin products and dosage. Since the global introduction of standard active immunisation against measles and the concomitant reduction in virus circulation, the levels of measles virus (MV)-specific IgG antibodies in the population have dropped. Read More

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December 2018
5 Reads

Vaccination Guidelines for Patients With Immune-Mediated Disorders on Immunosuppressive Therapies.

J Cutan Med Surg 2018 Nov 21:1203475418811335. Epub 2018 Nov 21.

9 Faculty of Medicine, University of British Columbia, Vancouver, BC, Canada.

Background:: Patients with immune-mediated diseases on immunosuppressive therapies have more infectious episodes than healthy individuals, yet vaccination practices by physicians for this patient population remain suboptimal.

Objectives:: To evaluate the safety and efficacy of vaccines in individuals exposed to immunosuppressive therapies and provide evidence-based clinical practice recommendations.

Methods:: A literature search for vaccination safety and efficacy in patients on immunosuppressive therapies (2009-2017) was conducted. Read More

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November 2018
2 Reads

[Epidemiological and pathogenic characteristics of mumps in Fujian province, 2005-2017].

Zhonghua Liu Xing Bing Xue Za Zhi 2018 Oct;39(10):1356-1361

Fujian Provincial Key Laboratory of Zoonosis Research, Fujian Provincial Center for Disease Control and Prevention, Fuzhou 350001, China.

To understand the epidemiological and etiological characteristics of mumps in Fujian province, 2005-2017. All the reported mumps cases were collected through the National Notifiable Disease Information Management System, 2005-2017. Active search and interviews were conducted to collect the information on vaccination of mumps. Read More

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October 2018
4 Reads

Mumps outbreak with high complication rates among residents in a university teaching hospital.

Am J Infect Control 2018 Nov 13. Epub 2018 Nov 13.

Department of Hospital Epidemiology, Hospital Universitario Dr. José Eleuterio González, Universidad Autónoma de Nuevo León, Monterrey, Mexico. Electronic address:

According to the US Advisory Committee on Immunization Practices recommendations, only health care personnel (HCP) with adequate evidence of immunity should be exposed to patients with a suspected diagnosis of mumps. Here we report a hospital-outbreak scenario among medical residents with no previous vaccination record against mumps who had a high rate of complications. We also describe the importance and impact of full and proper vaccination, as well as isolation, of HCP in stopping the outbreak and, finally, review opportunities for improving the safety of HCP. Read More

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November 2018

Incidences of Varicella in Children of Jeju-do, Republic of Korea, 2005-2016: Age-Period-Cohort Analysis.

Epidemiol Health 2018 Nov 8:e2018054. Epub 2018 Nov 8.

Jeju National University School of Medicine, Jeju, Korea.

Objectives: Although the nationwide inoculation rate of varicella vaccine was about 95% in Korean children, the notified numbers of varicella cases are increasing till now, unexpectedly. To suggest some hypotheses about the gap, an age-period-cohort (APC) analysis as descriptive epidemiology study was conducted for children resident in Jeju-do, Republic of Korea (ROK).

Methods: The raw data was the nationwide database for insurance claim of healthcare fee suggested by National Health Insurance Service, ROK. Read More

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November 2018
6 Reads

Mumps in Poland in 2016

Przegl Epidemiol 2018 ;72(3):281-285

Nstional Institute of Public Health-National Institute of Hygiene, Department of Epidemiology of Infectious Diseases and Surveillance

Background: Vaccination against mumps from 2003 is mandatory in Poland and given as two dose scheme with MMR vaccine (mumps, measles, and rubella). Earlier this vaccination was only recommended. Despite observed decline in mumps incidence for over a decade which is a result of conducted vaccinations, mumps is still a common disease among the children. Read More

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January 2018
1 Read

Perspectives on the Measles, Mumps and Rubella Vaccination among Somali Mothers in Stockholm.

Int J Environ Res Public Health 2018 Nov 1;15(11). Epub 2018 Nov 1.

Equity and Health Policy Research Group, Department of Public Health Sciences, Karolinska Institute, Tomtebodavägen 18, 171 77 Stockholm, Sweden.

: Vaccination hesitancy and skepticism among parents hinders progress in achieving full vaccination coverage. Swedish measles, mumps and rubella (MMR) vaccine coverage is high however some areas with low vaccination coverage risk outbreaks. This study aimed to explore factors influencing the decision of Somali parents living in the Rinkeby and Tensta districts of Stockholm, Sweden, on whether or not to vaccinate their children with the measles, mumps and rubella (MMR) vaccine. Read More

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November 2018
5 Reads

Atypical Kawasaki Disease in a 4 Years Old Child with Mumps.

JNMA J Nepal Med Assoc 2018 Jul-Aug;56(212):811-814

Department of Pediatrics, Kathmandu Medical College Teaching Hospital, Kathmandu, Nepal.

Kawasaki disease is an acute febrile condition seen in children. However, it is also well recognized that some patients do not fulfill the classic diagnostic criteria for the diagnosis of Kawasaki disease. The incomplete form of Kawasaki disease is termed as 'Incomplete KD' or 'Atypical KD'. Read More

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November 2018
1 Read

Effects of a Public Subsidization Program for Mumps Vaccine on Reducing the Disease Burden in Nagoya City, Japan.

Jpn J Infect Dis 2018 Oct 31. Epub 2018 Oct 31.

Department of Public Health, Osaka City University Graduate School of Medicine.

Nagoya City initiated a public subsidization program for mumps vaccination using either Torii- or Hoshino-strains in August 2010. To demonstrate the effects of the program, we used publicly available information from Nagoya City to investigate the changes in immunization rate and numbers of patients who developed post-immunization adverse reactions, including post-vaccinal aseptic meningitis, in the 7 years since its initiation. We also investigated the numbers of mumps patients reported during this period by sentinel sites in a national database. Read More

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October 2018
1 Read

Immune-Mediated Systemic Vasculitis as the Proposed Cause of Sudden-Onset Sensorineural Hearing Loss following Lassa Virus Exposure in Cynomolgus Macaques.

MBio 2018 Oct 30;9(5). Epub 2018 Oct 30.

Office of the Chief Scientists, U.S. Army Medical Research Institute of Infectious Diseases, Fort Detrick, Frederick, Maryland, USA

Lassa virus (LASV) causes a severe, often fatal hemorrhagic disease in regions in Africa where the disease is endemic, and approximately 30% of patients develop sudden-onset sensorineural hearing loss after recovering from acute disease. The causal mechanism of hearing loss in LASV-infected patients remains elusive. Here, we report findings after closely examining the chronic disease experienced by surviving macaques assigned to LASV exposure control groups in two different studies. Read More

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October 2018
1 Read

[Non-specific effects of vaccination in Denmark].

Ugeskr Laeger 2018 Oct;180(44)

Studies from low-income countries show, that vaccines may have effects on overall mortality, so-called non-specific effects, which cannot be explained by the effect on the targeted infection. We investigated if vaccines have non-specific effects on infectious disease morbidity in Denmark, and we found beneficial non-specific effects of measles-mumps-rubella vaccine, which have now been confirmed in other high-income settings. Danish investment in research in low-income countries may lead to important new insights with consequences not only for the recipient country but also for Denmark. Read More

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October 2018
4 Reads

Viral Encephalitis.

Neurol Clin 2018 Nov 20;36(4):705-724. Epub 2018 Sep 20.

Division of Neuroimmunology and Neuroinfectious Diseases, Department of Neurology, Johns Hopkins Encephalitis Center, Johns Hopkins University School of Medicine, 600 N Wolfe Street, Baltimore, MD 21287, USA.

Viruses are a frequent cause of encephalitis. Common or important viruses causing encephalitis include herpesviruses, arboviruses, enteroviruses, parechoviruses, mumps, measles, rabies, Ebola, lymphocytic choriomeningitis virus, and henipaviruses. Other viruses may cause an encephalopathy. Read More

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November 2018
8 Reads

Measles Outbreak in a Highly Vaccinated Population - Israel, July-August 2017.

MMWR Morb Mortal Wkly Rep 2018 Oct 26;67(42):1186-1188. Epub 2018 Oct 26.

On August 6, 2017, the Israeli Defense Force Public Heath Branch (IDFPHB) was notified of two suspected measles cases. IDFPHB conducted an epidemiologic investigation, which identified nine measles cases in a population with high measles vaccination coverage. All measles patients had signs and symptoms consistent with modified measles (i. Read More

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October 2018
14 Reads

A randomized, blinded, placebo-controlled trial comparing antibody responses to homeopathic and conventional vaccines in university students.

Vaccine 2018 Nov 21;36(48):7423-7429. Epub 2018 Oct 21.

Hospital for Sick Childrene, 555 University Avenue Toronto, Ontario M5G 1X8, Canada.

Background: Homeopathic vaccines are licensed in many countries but scientific data to support their use are sparse. The goal of this study was to compare the antibody response of homeopathic and conventional vaccines and placebo in young adults. We hypothesized that there would be no significant difference between homeopathic vaccines and placebo, while there would be a significant increase in antibodies in those received conventional vaccines. Read More

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November 2018
2 Reads

Emerging Topics in Vaccine Therapeutics for Adolescents and Adults: An Update for Immunizing Pharmacists.

J Pharm Pract 2018 Oct 23:897190018802937. Epub 2018 Oct 23.

3 Department of Pharmacy Practice and Administration, Ernest Mario School of Pharmacy, Rutgers University, Piscataway, NJ, USA.

Vaccine therapeutics and the practice of immunization provision are ever-changing. As pharmacy-based immunization services continue to flourish in the United States, more and more patients are requesting both routine and travel vaccines in community pharmacies. However, vaccine recommendations from the Centers for Disease Control and Prevention/Advisory Committee on Immunization Practices (CDC/ACIP) can sometimes differ from product-specific US Food and Drug Administration (FDA)-indicated uses. Read More

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October 2018
7 Reads

secretor genotype and susceptibility to infections and chronic conditions in the ALSPAC cohort.

Wellcome Open Res 2018 25;3:65. Epub 2018 Sep 25.

Medical Research Council Integrative Epidemiology Unit, Avon Longitudinal Study of Parents and Children, Population Health Science, Bristol Medical School, University of Bristol, Bristol, BS8 2BN, UK.

The (fucosyltransferase-2) gene determines blood group secretor status. Being homozygous for the inactive "non-secretor" rs601338(A) allele confers resistance to certain infections (e.g. Read More

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September 2018
8 Reads

A process evaluation of how the routine vaccination programme is implemented at GP practices in England.

Implement Sci 2018 Oct 22;13(1):132. Epub 2018 Oct 22.

Faculty of Public Health and Policy, London School of Hygiene and Tropical Medicine, 15-17 Tavistock Place, London, WC1H 9SH, UK.

Background: In recent years, the incidence of several pathogens of public health importance (measles, mumps, pertussis and rubella) has increased in Europe, leading to outbreaks. This has included England, where GP practices implement the vaccination programme based on government guidance. However, there has been no study of how implementation takes place, which makes it difficult to identify organisational variation and thus limits the ability to recommend interventions to improve coverage. Read More

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October 2018
2 Reads

Hidden diagnosis behind viral infection: the danger of anchoring bias.

BMJ Case Rep 2018 Oct 21;2018. Epub 2018 Oct 21.

Department of General Pediatrics and Interdisciplinary Medicine, National Center for Child Health and Development, Tokyo, Japan.

Anchoring bias is one of the most common diagnostic biases that may lead to closed-minded thinking and could result in unnecessary tests, inappropriate patient management and even misdiagnosis. A 4-year-old boy was brought to the emergency department because of shaking chills. On the basis of bilateral swollen preauricular areas, high level of serum amylase and the prevalence of mumps, he initially received a diagnosis of mumps in spite of the shaking chills. Read More

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October 2018
4 Reads

Point-of-care-testing of α-amylase activity in human blood serum.

Biosens Bioelectron 2019 Jan 9;124-125:75-81. Epub 2018 Oct 9.

Centre for Nanotechnology, Indian Institute of Technology Guwahati, Assam 781039, India; Department of Chemical Engineering, Indian Institute of Technology Guwahati, Assam 781039, India. Electronic address:

Activity of α-amylase enzyme in human serum indicates the onset of pancreatitis, mumps, cancer, stress, and depression. Herein we design and develop a biosensor for the point-of-care-testing (POCT) of α-amylase concentration in serum. The biosensor is composed of a glass substrate coated with an electrically conducting poly-aniline-emeraldine-salt (PANI-ES) film covered with starch-coated gold nanoparticles (SAuNPs). Read More

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January 2019
4 Reads

Mumps Outbreak in a Marshallese Community - Denver Metropolitan Area, Colorado, 2016-2017.

MMWR Morb Mortal Wkly Rep 2018 Oct 19;67(41):1143-1146. Epub 2018 Oct 19.

In January 2017, the Colorado Department of Public Health and Environment (CDPHE) identified four epidemiologically linked cases of mumps among persons from a Marshallese community who were members of the same church in the Denver metropolitan area. During 2016-2017, sizable outbreaks of mumps reported in Arkansas, Hawaii, and Washington also affected the Marshallese population (1). CDPHE, the Tri-County Health Department (TCHD), and Denver Public Health collaborated to conduct an outbreak investigation during January-March 2017 using active and passive surveillance that identified 17 confirmed and 30 probable cases. Read More

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October 2018
16 Reads

Divergent approaches in the vaccination of recently arrived migrants to Europe: a survey of national experts from 32 countries, 2017.

Euro Surveill 2018 Oct;23(41)

Department of Internal Medicine/Infectious Diseases, University of Groningen, University Medical Centre Groningen, Groningen, the Netherlands.

BackgroundMigrants within the European Union and European Economic Area (EU/EEA) may be underimmunised and lack documentation on previous vaccinations. We investigated approaches to vaccination in recently arrived adult and child migrants, and guideline availability and implementation. : Between March and May 2017, a national vaccination expert from every EU/EEA country and Switzerland completed an electronic questionnaire. Read More

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October 2018
3 Reads

Mass spectrometry-based investigation of measles and mumps virus proteome.

Virol J 2018 10 16;15(1):160. Epub 2018 Oct 16.

Centre for Research and Knowledge Transfer in Biotechnology, University of Zagreb, Rockefellerova 10, HR-10 000, Zagreb, Croatia.

Background: Measles (MEV) and mumps virus (MUV) are enveloped, non-segmented, negative single stranded RNA viruses of the family Paramyxoviridae, and are the cause of measles and mumps, respectively, both preventable by vaccination. Aside from proteins coded by the viral genome, viruses are considered to contain host cell proteins (HCPs). The presence of extracellular vesicles (ECVs), which are often co-purified with viruses due to their similarity in size, density and composition, also contributes to HCPs detected in virus preparations, and this has often been neglected. Read More

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October 2018
8 Reads

Hong Kong Institute of Allergy and Hong Kong Society for Paediatric Immunology Allergy & Infectious Diseases joint consensus statement 2018 on vaccination in egg-allergic patients.

Hong Kong Med J 2018 Oct;24(5):527-531

Allergy Centre, Hong Kong Sanatorium and Hospital, Happy Valley, Hong Kong.

Vaccination of egg-allergic individuals has been a historical concern, particularly for influenza and measles-mumps-rubella-varicella vaccines that are developed in chicken egg embryos or chicken cell fibroblasts. The egg proteins in these vaccines were believed to trigger an immediate allergic reaction in egg-allergic individuals. However, recently published international guidelines have updated their recommendations and now state that these vaccines can be safely administered to egg-allergic individuals. Read More

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October 2018
5 Reads

Immunosuppression Does Not Affect Antibody Concentrations to Measles, Mumps, and Rubella in Patients with Inflammatory Bowel Disease.

Dig Dis Sci 2018 Oct 13. Epub 2018 Oct 13.

School of Pharmacy, School of Medicine and Public Health, University of Wisconsin-Madison, 777 Highland Avenue, Madison, WI, 53705, USA.

Background: The Advisory Committee on Immunization Practices (ACIP) recommends using the immunization record and not serologic testing to determine immunity against measles and rubella in the general population, due to potential false negatives. However, it is unknown whether the immune response is less durable among patients who are immunosuppressed.

Aims: The primary aim of this study was to evaluate sustained vaccine-induced measles, mumps, and rubella (MMR) antibody concentrations in immunosuppressed patients with inflammatory bowel disease (IBD). Read More

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October 2018
2 Reads

The Clinical Impact and Cost-effectiveness of MMR Vaccination to Prevent Measles Importations among US International Travelers.

Clin Infect Dis 2018 Oct 11. Epub 2018 Oct 11.

Medical Practice Evaluation Center, Department of Medicine, Massachusetts General Hospital, Boston, MA.

Background: Measles importations and subsequent spread from US travelers returning from abroad are responsible for most measles cases in the US. Increasing measles-mumps-rubella (MMR) vaccination among departing US travelers could reduce the clinical impact and costs of measles in the US.

Methods: We designed a decision tree to evaluate MMR vaccination at a pretravel health encounter, compared with no encounter. Read More

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October 2018
2 Reads

Community-acquired acute meningitis and encephalitis: a narrative review.

Authors:
Miles H Beaman

Med J Aust 2018 Nov 15;209(10):449-454. Epub 2018 Oct 15.

Western Diagnostic Pathology, Perth, WA

Meningitis and encephalitis are medical emergencies. Patients need prompt evaluation and immediate empiric therapy to reduce the likelihood of fatal outcomes and chronic neurological sequelae. Conjugate bacterial vaccines have significantly reduced the incidence of bacterial meningitis, especially in children. Read More

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November 2018
12 Reads

Vaccination Coverage Among Children Aged 19-35 Months - United States, 2017.

MMWR Morb Mortal Wkly Rep 2018 Oct 12;67(40):1123-1128. Epub 2018 Oct 12.

Immunization Services Division, National Center for Immunization and Respiratory Diseases, CDC.

The Advisory Committee on Immunization Practices (ACIP) recommends routine vaccination by age 24 months against 14 potentially serious illnesses (1). CDC used data from the 2017 National Immunization Survey-Child (NIS-Child) to assess vaccination coverage at national, state, territorial, and selected local levels among children aged 19-35 months in the United States. Coverage remained high and stable overall, exceeding 90% for ≥3 doses of poliovirus vaccine, ≥1 dose of measles, mumps, and rubella vaccine (MMR), ≥3 doses of hepatitis B vaccine (HepB), and ≥1 dose of varicella vaccine. Read More

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October 2018
3 Reads

Vaccination Coverage for Selected Vaccines and Exemption Rates Among Children in Kindergarten - United States, 2017-18 School Year.

MMWR Morb Mortal Wkly Rep 2018 Oct 12;67(40):1115-1122. Epub 2018 Oct 12.

State and local school vaccination requirements exist to ensure that students are protected from vaccine-preventable diseases (1). This report summarizes vaccination coverage and exemption estimates collected by state and local immunization programs* for children in kindergarten (kindergartners) in 49 states and the District of Columbia (DC) and kindergartners provisionally enrolled (attending school without complete vaccination or exemption while completing a catch-up vaccination schedule) or in a grace period (a set interval during which a student may be enrolled and attend school without proof of complete vaccination or exemption) for 28 states. Median vaccination coverage was 95. Read More

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October 2018
3 Reads

[Quantifying the impact of mass vaccination programmes on notified cases in the Netherlands].

Ned Tijdschr Geneeskd 2018 09 20;162. Epub 2018 Sep 20.

Centrum Infectieziektebestrijding, RIVM, Bilthoven, Nederland.

Objective: To quantify the impact of long-standing vaccination programmes on notified cases in the Netherlands.

Design: Estimates based on model projections of historical morbidity data.

Method: We collected and digitised previously unavailable monthly case notifications of diphtheria, poliomyelitis, mumps and rubella in the Netherlands over the period 1919-2015. Read More

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September 2018
1 Read

Entry, Replication, Immune Evasion, and Neurotoxicity of Synthetically Engineered Bat-Borne Mumps Virus.

Cell Rep 2018 Oct;25(2):312-320.e7

Infection Biology Unit, German Primate Center, 37077 Göttingen, Germany.

Bats harbor a plethora of viruses with an unknown zoonotic potential. In-depth functional characterization of such viruses is often hampered by a lack of virus isolates. The genome of a virus closely related to human mumps viruses (hMuV) was detected in African fruit bats, batMuV. Read More

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October 2018
1 Read

Cost of Public Health Response and Outbreak Control With a Third Dose of Measles-Mumps-Rubella Vaccine During a University Mumps Outbreak-Iowa, 2015-2016.

Open Forum Infect Dis 2018 Oct 4;5(10):ofy199. Epub 2018 Oct 4.

Division of Viral Diseases, National Center for Immunization and Respiratory Diseases, Centers for Disease Control and Prevention, Atlanta, Georgia.

Background: The United States is experiencing mumps outbreaks in settings with high 2-dose measles-mumps-rubella (MMR) vaccine coverage, mainly universities. The economic impact of mumps outbreaks on public health systems is largely unknown. During a 2015-2016 mumps outbreak at the University of Iowa, we estimated the cost of public health response that included a third dose of MMR vaccine. Read More

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October 2018
6 Reads

Long-term monitoring of virus antibody titers in human intravenous immunoglobulin lots derived from donors in Japan.

Transfusion 2018 Nov 4;58(11):2617-2626. Epub 2018 Oct 4.

Research and Development Division, Japan Blood Products Organization, Tokyo, Japan.

Background: Intravenous immunoglobulin (IVIG) contains immunoglobulin G against various viruses, except those that have been screened, such as human immunodeficiency and hepatitis C viruses. Antivirus titers reflect the serostatus of the blood donor population in the collection region and are of clinical interest.

Study Design And Methods: During the past 10 years, measles, mumps, rubella, varicella-zoster, hepatitis A and B, Epstein-Barr, and human respiratory syncytial viruses; human parainfluenza viruses 1, 2, and 3; human herpes simplex viruses 1 and 2; human herpesvirus 6; cytomegalovirus (CMV); human adenoviruses (HAdVs) 1, 2, 3, 7, and 11; human parvovirus B19; and human echovirus 9 and 11 titers in IVIG lots have been measured by a commercial testing facility. Read More

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November 2018
5 Reads

Investigation of an increase in large local reactions following vaccine schedule change to include DTaP-HB-IPV-Hib (Infanrix-hexa®) and MMRV (ProQuad®) at 18 months of age.

Vaccine 2018 Oct 27;36(45):6688-6694. Epub 2018 Sep 27.

Institut national de santé publique du Québec, Quebec, Canada; Université Laval, Département de médecine sociale et préventive, Quebec, Canada; CHU de Québec Research Center, Laval University, Quebec, Canada. Electronic address:

Context: In 2015 in Quebec, Canada, the passive vaccine adverse event reporting system detected an increase in large local reactions associated with vaccines recommended at the 18-month visit. This followed changes to the pediatric vaccine schedule to include hexavalent diphtheria-tetanus-acellular-pertusis-inactivated polio-Haemophilus influenzae type b-hepatitis B vaccine (DTaP-IPV-Hib-HB, Infanrix-hexa®, GSK) and quadrivalent measles-mumps-rubella-varicella vaccine (MMRV, ProQuad®, Merck) as 18-month booster doses.

Objectives: To determine if the excess of large local reactions was caused by a specific vaccine or their co-administration in the same limb or during the same visit. Read More

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October 2018
7 Reads