5,636 results match your criteria Multisystem Organ Failure of Sepsis


Hemodynamic consequences of intravenously given E. coli suspension: observations in a fulminant sepsis model in pigs, a descriptive case-control study.

Eur J Med Res 2019 Feb 13;24(1):11. Epub 2019 Feb 13.

Department of Anesthesiology and Intensive Care, Faculty of Medicine, University of Debrecen, Nagyerdei krt 98, Debrecen, 4032, Hungary.

Background: The aim of the present work was to assess systemic hemodynamic changes using PiCCo monitoring in a porcine model of E. coli-induced fulminant sepsis.

Methods: Thirty-one healthy female Hungahib pigs were randomly assigned into control (n = 15) or septic groups (n = 16). Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1186/s40001-019-0372-yDOI Listing
February 2019
1 Read

Outcome of pediatric cardiac surgery and predictors of major complication in a developing country.

Ann Pediatr Cardiol 2019 Jan-Apr;12(1):38-44

Integrated Cardiac Centre, Dr. Cipto Mangunkusumo Hospital, Jakarta, Indonesia.

Background: Evaluating outcome and identifying predictors of major complications among children undergoing cardiac surgery are essential to improve care. We evaluated short-term outcomes of postcardiac surgery and predictors of major complications in a national referral hospital in Indonesia.

Methods: A prospective cohort study was conducted from April 2014 to March 2015 on all children undergoing cardiac surgery. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.4103/apc.APC_146_17DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6343386PMC
February 2019
1 Read

Delayed Antibiotic Therapy and Organ Dysfunction in Critically Ill Septic Patients in the Emergency Department.

J Clin Med 2019 Feb 8;8(2). Epub 2019 Feb 8.

Department of Emergency Medicine, Samsung Medical Center, Sungkyunkwan University School of Medicine, Gangnam-gu, Seoul 06351, Korea.

Background: We investigated the effect of antibiotic timing on outcomes based on changes in surrogate markers of organ failure, including platelet, serum bilirubin, serum creatinine levels, and the PaO₂/FiO₂ (P/F) ratio.

Methods: This was a single-center, retrospective observational study of critically ill septic patients who presented to the emergency department (ED). The study period extended from August 2008 to September 2016. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.3390/jcm8020222DOI Listing
February 2019
1 Read

Modulation of the sigma-1 receptor-IRE1 pathway is beneficial in preclinical models of inflammation and sepsis.

Sci Transl Med 2019 Feb;11(478)

Center for Brain Immunology and Glia, Department of Neuroscience, School of Medicine, University of Virginia, Charlottesville, VA 22908, USA.

Sepsis is an often deadly complication of infection in which systemic inflammation damages the vasculature, leading to tissue hypoperfusion and multiple organ failure. Currently, the standard of care for sepsis is predominantly supportive, with few therapeutic options available. Because of increased sepsis incidence worldwide, there is an urgent need for discovery of novel therapeutic targets and development of new treatments. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1126/scitranslmed.aau5266DOI Listing
February 2019
1 Read

Gender Disparities in Trauma Care: How Sex Determines Treatment, Behavior, and Outcome.

Anesthesiol Clin 2019 Mar 27;37(1):107-117. Epub 2018 Nov 27.

Acute Care Surgery [Trauma, Burn, Critical Care, Emergency Surgery], Department of Surgery, Trauma and Surgical Critical Care, University of Michigan Health System, University Hospital, Room 1C340, 1500 East Medical Center Drive, Ann Arbor, MI 48109-5033, USA.

Trauma data bank and other research reveal sex disparities in trauma care. Risk-taking behaviors leading to traumatic injury have been associated with sex, menstrual cycle timing, and cortisol levels. Trauma patient treatment stratified by sex reveals differences in access to services at trauma centers as well as specific treatments, such as venous thromboembolism prophylaxis and massive transfusion component ratios. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1016/j.anclin.2018.09.007DOI Listing
March 2019
1 Read

[Staphylococcal toxic shock syndrome should be considered in the event of diffuse erythema with fever and shock].

Ann Dermatol Venereol 2019 Jan 25. Epub 2019 Jan 25.

Service de dermatologie-infectiologie, CHI Fréjus Saint-Raphaël, 240, avenue de Saint-Lambert, 83600 Fréjus, France.

Background: Toxic shock syndrome (TSS) was first described by Todd in 1978. The relevant Lancet publication reported 7 cases of children with fever, exanthema, hypotension and diarrhoea associated with multiple organ failure. An association between TSS and use of hyper-absorbent tampons in menstruating women was discovered in the 1980s. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1016/j.annder.2018.12.002DOI Listing
January 2019
2 Reads

Comparison of Various Severity Assessment Scoring Systems in Patients with Sepsis in a Tertiary Care Teaching Hospital.

Indian J Crit Care Med 2018 Dec;22(12):842-845

Department of Pharmacy Practice, Manipal College of Pharmaceutical Sciences, Manipal, Karnataka, India.

Background: Sepsis is a complex condition defined by the systemic response to infection. Severity assessment scoring systems are used to aid the physician in deciding whether aggressive treatment is needed or not. In this study, various severity assessment scoring systems, namely Acute Physiology and Chronic Health Evaluation II (APACHE II), Rapid Emergency Medicine Score (REMS), Sequential Organ Failure Assessment (SOFA), Multiple Organ Dysfunction Score (MODS), Predisposition, Infection, Response, and Organ Dysfunction (PIRO), and Mortality in Emergency Department Sepsis (MEDS), were compared to assess their sensitivity and specificity. Read More

View Article

Download full-text PDF

Source
http://www.ijccm.org/text.asp?2018/22/12/842/247745
Publisher Site
http://dx.doi.org/10.4103/ijccm.IJCCM_322_18DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6311975PMC
December 2018
13 Reads

Circulating histone H3 levels in septic patients are associated with coagulopathy, multiple organ failure, and death: a single-center observational study.

Thromb J 2019 14;17. Epub 2019 Jan 14.

1Department of Emergency and Intensive Care Medicine, Kagoshima University Graduate School of Medical and Dental Sciences, 8-35-1 Sakuragaoka, Kagoshima, 890-8544 Japan.

Background: Nuclear histone proteins are released into the extracellular space, and act as major mediators of coagulopathy and remote organ failure in septic animals. However, the circulating histone levels in septic patients have not been precisely quantified.

Methods: Using a novel enzyme-linked immunosorbent assay for histone H3 detection, we measured the serum histone H3 levels in 85 patients admitted to the intensive care unit because of infectious diseases. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1186/s12959-018-0190-4DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6330748PMC
January 2019
2 Reads

IMPACT probability of poor outcome and plasma cytokine concentrations are associated with multiple organ dysfunction syndrome following traumatic brain injury.

J Neurosurg 2019 Jan 11:1-7. Epub 2019 Jan 11.

Departments of1Neurosurgery and.

OBJECTIVETraumatic brain injury (TBI) is a major cause of morbidity and mortality. Multiple organ dysfunction syndrome (MODS) occurs frequently after TBI and independently worsens outcome. The present study aimed to identify potential admission characteristics associated with post-TBI MODS. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.3171/2018.8.JNS18676DOI Listing
January 2019
4 Reads

Mitochondrial Function in the Kidney and Heart, but not the Brain, is Mainly Altered in an Experimental Model of Endotoxaemia.

Shock 2019 Jan 9. Epub 2019 Jan 9.

Latvian Institute of Organic Synthesis, Aizkraukles Str. 21, Riga, LV-1006, Latvia.

Significant impairments in mitochondrial function are associated with the development of multi-organ failure in sepsis/endotoxaemia, but the data on the dynamics of simultaneous mitochondrial impairment in multiple organs are limited. The aim of this study was to evaluate the changes in heart, brain and kidney mitochondrial function in an experimental model of lipopolysaccharide (LPS)-induced endotoxaemia.Samples were collected 4 and 24 h after single injection of LPS (10 mg/kg) in mice. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1097/SHK.0000000000001315DOI Listing
January 2019
1 Read

Vancomycin dosing, monitoring and toxicity: Critical review of the clinical practice.

Clin Exp Pharmacol Physiol 2019 Jan 9. Epub 2019 Jan 9.

Botucatu School of Medicine, University São Paulo State-UNESP, Botucatu, Brazil.

Vancomycin is an antibiotic used in the treatment of infections caused by multidrug-resistant Gram-positive bacteria, especially methicillin-resistant Staphylococcus aureus. In the last decades, vancomycin has been widely used in hospital environments due to the increasing incidence of sepsis and septic shock. Sepsis may lead to multiple organ failure; it is considered a risk factor for the development of acute kidney injury (AKI), with an overall mortality rate of around 45%, which can reach the surprising rate of 70% with the combination of AKI and sepsis. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1111/1440-1681.13066DOI Listing
January 2019
5 Reads

Chemically synthesized Secoisolariciresinol diglucoside (LGM2605) improves mitochondrial function in cardiac myocytes and alleviates septic cardiomyopathy.

J Mol Cell Cardiol 2019 Feb 3;127:232-245. Epub 2019 Jan 3.

Center for Translational Medicine and Department of Pharmacology, Lewis Katz School of Medicine, Temple University, Philadelphia, PA, USA. Electronic address:

Sepsis is the overwhelming systemic immune response to infection, which can result in multiple organ dysfunction and septic shock. Myocardial dysfunction during sepsis is associated with advanced disease and significantly increased in-hospital mortality. Our group has shown that energetic failure and excess reactive oxygen species (ROS) generation constitute major components of myocardial dysfunction in sepsis. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1016/j.yjmcc.2018.12.016DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6359996PMC
February 2019
2 Reads

Variability of mitochondrial respiration in relation to sepsis-induced multiple organ dysfunction.

Physiol Res 2018 Dec;67(Supplementum 4):S577-S592

Institute of Physiology, Faculty of Medicine in Plzeň, Charles University, Plzeň, Czech Republic.

Ample experimental evidence suggests that sepsis could interfere with any mitochondrial function; however, the true role of mitochondrial dysfunction in the pathogenesis of sepsis-induced multiple organ dysfunction is still a matter of controversy. This review is primarily focused on mitochondrial oxygen consumption in various animal models of sepsis in relation to human disease and potential sources of variability in experimental results documenting decrease, increase or no change in mitochondrial respiration in various organs and species. To date, at least three possible explanations of sepsis-associated dysfunction of the mitochondrial respiratory system and consequently impaired energy production have been suggested: 1. Read More

View Article

Download full-text PDF

Source
December 2018
1 Read

Posterior reversible encephalopathy syndrome (PRES) and infection: a systematic review of the literature.

Neurol Sci 2019 Jan 2. Epub 2019 Jan 2.

Department of Biomedical Sciences and Morphological and Functional Imaging, University of Messina, Policlinico "G. Martino" Via Consolare Valeria 1, 98100, Messina, Italy.

Posterior reversible encephalopathy syndrome (PRES) is an encephalopathy characterized by a rapid onset of symptoms including headache, seizures, confusion, blurred vision, and nausea associated with a typical magnetic resonance imaging appearance of reversible subcortical vasogenic edema prominent and not exclusive of parieto-occipital lobes. Vasogenic edema is caused by a blood-brain barrier leak induced by endothelial damage or a severe arterial hypertension exceeding the limits of cerebral blood flow autoregulation. Although the exact pathophysiological mechanism is still unclear, frequent conditions that may induce PRES include severe hypertension, eclampsia/pre-eclampsia, acute kidney diseases and failure, immunosuppressive therapy, solid organ, or bone marrow transplantation. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1007/s10072-018-3651-4DOI Listing
January 2019
1 Read

Acute-on-chronic liver failure in children with biliary atresia awaiting liver transplantation.

Pediatr Transplant 2019 Mar 30;23(2):e13339. Epub 2018 Dec 30.

Paediatric Liver, Gastroenterology and Nutrition Centre, King's College Hospital, London, UK.

Objectives: Acute-on-chronic liver failure (ACLF) is an acute decompensation of cirrhosis complicated by other organ failure and is associated with increased mortality and morbidity. ACLF has not been studied in children with biliary atresia (BA), which is the commonest indication for pediatric liver transplantation (LT) worldwide. This study aims to evaluate ACLF and outcomes in children with BA while awaiting deceased donor LT. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1111/petr.13339DOI Listing
March 2019
7 Reads

Platelet Glycoprotein VI Haplotypes and the Presentation of Paediatric Sepsis.

Thromb Haemost 2018 Dec 31. Epub 2018 Dec 31.

Department of Physiology and Biophysics, University of Arkansas for Medical Sciences, Little Rock, Arkansas, United States.

Sepsis triggers a complex series of pathophysiologic events involving inflammatory responses and coagulation abnormalities. While circulating blood platelets are well-characterized for their contributions to coagulation, increasingly platelet-dependent effects on inflammation are being recognized. Here, we focus on the platelet membrane receptor, glycoprotein VI (GPVI), and its role in platelet microparticle (pMP) release. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1055/s-0038-1676794DOI Listing
December 2018
2 Reads

Potential Risk Factors for In-Hospital Mortality in Patients with Moderate-to-Severe Blunt Multiple Trauma Who Survive Initial Resuscitation.

Emerg Med Int 2018 22;2018:6461072. Epub 2018 Nov 22.

Department of Infectious Disease and Clinical Microbiology, Inonu University, School of Medicine, Malatya, Turkey.

Introduction: The aim was to identify risk factors that influence in-hospital mortality for patients with moderate-to-severe blunt multiple trauma (BMT) who survive initial resuscitation.

Methods: The prospective study involved 195 adult patients with BMT who were admitted to a referral hospital's emergency department (ED) between May 1, 2015, and May 31, 2016.

Results: Forty-three (22%) of the 195 patients died in hospital. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1155/2018/6461072DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6282151PMC
November 2018
1 Read

Ivabradine: Evidence and current role in cardiovascular diseases and other emerging indications.

Indian Heart J 2018 Dec 20;70 Suppl 3:S435-S441. Epub 2018 Aug 20.

Dr. Newale Health Centre, Navi Mumbai, 400614, India. Electronic address:

Increased heart rate (HR) is associated with deleterious effects on several disease conditions. Chronic heart failure (CHF) is one of the cardiovascular diseases with recurrent hospitalization burden and an ongoing drain on health-care expenditure. Despite advancement in medicine, management of CHF remains a challenge to health-care providers. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1016/j.ihj.2018.08.008DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6309574PMC
December 2018
1 Read

A case report and literature review: previously excluded tuberculosis masked by amiodarone induced lung injury.

BMC Pharmacol Toxicol 2018 Dec 29;19(1):88. Epub 2018 Dec 29.

Institute of Physiology and Pharmacology, Lithuanian University of Health Sciences, A. Mickeviciaus str. 9, 44307, Kaunas, LT, Lithuania.

Background: Amiodarone is an antiarrhythmic drug which is used to treat and prevent several dysrhythmias. This includes ventricular tachycardia and fibrillation, wide complex tachycardia, as well as atrial fibrillation (AF) and paroxysmal supraventricular tachycardia. Amiodarone may prove to be the agent of choice where the patient is hemodynamically unstable and unsuitable for direct current (DC) cardioversion. Read More

View Article

Download full-text PDF

Source
https://bmcpharmacoltoxicol.biomedcentral.com/articles/10.11
Publisher Site
http://dx.doi.org/10.1186/s40360-018-0279-1DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6311077PMC
December 2018
9 Reads

Systematic review and meta-analysis of the protective effect of resveratrol on multiple organ injury induced by sepsis in animal models.

Biomed Rep 2019 Jan 14;10(1):55-62. Epub 2018 Nov 14.

Intensive Care Unit, The Second Hospital of Shanxi Medical University, Taiyuan, Shanxi 030001, P.R. China.

Sepsis may directly lead to multiple organ failure, which is among the leading causes of mortality in critically ill patients. According to data released by the Global Sepsis Alliance, the number of mortalities due to sepsis exceeded the combined number for prostate cancer, breast cancer and AIDS in 2012. To date, studies have reported that resveratrol has marked positive effects including anti-inflammatory, anti-oxidative and pro-microcirculatory functions in sepsis-induced organ injury, significantly improving the survival time and mortality of sepsis animals. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.3892/br.2018.1169DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6299207PMC
January 2019
1 Read

A Comparative Review of Neutrophil Extracellular Traps in Sepsis.

Front Vet Sci 2018 28;5:291. Epub 2018 Nov 28.

Department of Anatomy, Physiology and Cell Biology, School of Veterinary Medicine, University of California, Davis Davis, CA, United States.

Sepsis is the leading cause of critical illness and mortality in human beings and animals. Neutrophils are the primary effector cells of innate immunity during sepsis. Besides degranulation and phagocytosis, neutrophils also release neutrophil extracellular traps (NETs), composed of cell-free DNA, histones, and antimicrobial proteins. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.3389/fvets.2018.00291DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6280561PMC
November 2018
3 Reads

Expression changes of CD177 and MPO as novel biomarkers in lung tissue of CLP model rats

Turk J Med Sci 2018 Dec 12;48(6):1321. Epub 2018 Dec 12.

National Institute of Scientific Research (INRS-ETE), University of Quebec, Quebec City, Canada

Background/aim: Sepsis is an unregulated systemic response to microbial invasion that can lead to multiple organ failure. This study aims at investigating the relationships among myeloperoxidase (MPO) and CD177 in major organ systems including whole blood, liver, and lung tissues in septic rats.

Materials And Methods: Sepsis was induced by cecal ligation and puncture (CLP) in female Wistar rats. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.3906/sag-1806-223DOI Listing
December 2018

Parenteral Succinate Reduces Systemic ROS Production in Septic Rats, but It Does Not Reduce Creatinine Levels.

Oxid Med Cell Longev 2018 6;2018:1928945. Epub 2018 Nov 6.

Departamento de Bioquímica Humana. CONICET, INBIOMED, Universidad de Buenos Aires, Facultad de Medicina, Buenos Aires ZIP C1121ABE, Argentina.

In sepsis, reactive oxygen species (ROS) production is increased. This process takes place mainly within the electron transport chain. ROS production is part of the pathophysiology of multiple organ failure in sepsis. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1155/2018/1928945DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6247384PMC
January 2019
1 Read

Therapeutic Plasma Exchange in Children With Thrombocytopenia-Associated Multiple Organ Failure: The Thrombocytopenia-Associated Multiple Organ Failure Network Prospective Experience.

Crit Care Med 2019 Mar;47(3):e173-e181

Department of Anesthesia and Critical Care Medicine, University of Pittsburgh School of Medicine, Children's Hospital of Pittsburgh, Pittsburgh, PA.

Objective: The objective was to compare the resolution of organ dysfunction, 28-day mortality, and biochemical markers in children with thrombocytopenia-associated multiple organ failure who received therapeutic plasma exchange versus no therapeutic plasma exchange.

Design: Observational longitudinal cohort study.

Setting: Nine U. Read More

View Article

Download full-text PDF

Source
http://Insights.ovid.com/crossref?an=00003246-900000000-9606
Publisher Site
http://dx.doi.org/10.1097/CCM.0000000000003559DOI Listing
March 2019
18 Reads
6.312 Impact Factor

Influence of inflammatory disorders on pharmacokinetics of lisofylline in rats: implications for studies in humans.

Xenobiotica 2018 Dec 11:1-12. Epub 2018 Dec 11.

b Faculty of Chemistry , Jagiellonian University , Cracow , Poland.

1. Despite the number of favourable properties of lisofylline (LSF), clinical trials on this compound have not yielded the expected results yet. 2. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1080/00498254.2018.1542516DOI Listing
December 2018
1 Read

Quantitative Measure of Intestinal Permeability Using Blue Food Coloring.

J Surg Res 2019 Jan 27;233:20-25. Epub 2018 Jul 27.

Dumont-UCLA Transplant Center, David Geffen School of Medicine, University of California at Los Angeles, Los Angeles, California. Electronic address:

Background: Loss of intestinal barrier integrity plays a fundamental role in the pathogenesis of various gastrointestinal diseases and is implicated in the onset of sepsis and multiple organ failure. An array of methods to assess different aspects of intestinal barrier function suffers from lack of sensitivity, prolonged periods of specimen collection, or high expense. We have developed a technique to measure the concentration of the food dye FD&C Blue #1 from blood and sought to assess its utility in measuring intestinal barrier function in humans. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1016/j.jss.2018.07.005DOI Listing
January 2019
7 Reads

Klotho deficiency aggravates sepsis-related multiple organ dysfunction.

Am J Physiol Renal Physiol 2019 Mar 5;316(3):F438-F448. Epub 2018 Dec 5.

Division of Nephrology, University of São Paulo School of Medicine , São Paulo , Brazil.

Sepsis-induced organ failure is characterized by a massive inflammatory response and oxidative stress. Acute kidney injury (AKI) occurs in approximately half of patients in septic shock, and the mortality associated with sepsis-induced AKI is unacceptably high. Klotho is a protein expressed by renal cells and has anti-senescence properties. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1152/ajprenal.00625.2017DOI Listing
March 2019
5 Reads

Diagnostic and predictive performance of biomarkers in patients with sepsis in an intensive care unit.

J Int Med Res 2018 Nov 26:300060518793791. Epub 2018 Nov 26.

1 Emergency Department, First Affiliated Hospital of Dalian Medical University, China.

Objective: This study was performed to compare the predictive performance of serum procalcitonin (PCT), N-terminal brain natriuretic propeptide (NT-proBNP), interleukin-6 (IL-6), prothrombin time (PT), thrombin time (TT), and Sequential Organ Failure Assessment (SOFA) score in the intensive care unit (ICU).

Methods: This retrospective cohort study enrolled 150 patients with sepsis and septic shock and 30 control patients without sepsis. Each patient was followed until death or 28 days. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1177/0300060518793791DOI Listing
November 2018
9 Reads

Potential therapy strategy: targeting mitochondrial dysfunction in sepsis.

Mil Med Res 2018 11 26;5(1):41. Epub 2018 Nov 26.

Trauma Research Center, First Hospital Affiliated to the Chinese PLA General Hospital, Fucheng Road 51, Haidian District, Beijing, 100048, China.

Recently, the definition of sepsis was concluded to be a life-threatening organ dysfunction caused by a dysregulated host response to infection. Severe patients always present with uncorrectable hypotension or hyperlactacidemia, which is defined as septic shock. The new definition emphasizes dysregulation of the host response and multiple organ dysfunction, which is partially attributed to metabolic disorders induced by energy crisis and oxidative stress. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1186/s40779-018-0187-0DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6260865PMC
November 2018
2 Reads

Characteristics, management, and in-hospital mortality among patients with severe sepsis in intensive care units in Japan: the FORECAST study.

Crit Care 2018 11 22;22(1):322. Epub 2018 Nov 22.

Division of Acute and Critical Care Medicine, Hokkaido University Graduate School of Medicine, Sapporo, Japan.

Background: Sepsis is a leading cause of death and long-term disability in developed countries. A comprehensive report on the incidence, clinical characteristics, and evolving management of sepsis is important. Thus, this study aimed to evaluate the characteristics, management, and outcomes of patients with severe sepsis in Japan. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1186/s13054-018-2186-7DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6251147PMC
November 2018
6 Reads

Outcomes of early relaparotomy in pediatric patients at Tikur Anbessa teaching hospital, Addis Ababa, Ethiopia: a five-year retrospective review.

BMC Surg 2018 Nov 16;18(1):99. Epub 2018 Nov 16.

Addis Ababa University, Addis Ababa, Ethiopia.

Background: Early relaparotomy is defined as relaparotomy within the first 30 days following surgery. The aim of this study is to explore the indications, outcomes and factors associated with relaparotomy in our pediatric population.

Methods: We performed a retrospective study of pediatric surgical patients (< 13 yrs. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1186/s12893-018-0436-xDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6240246PMC
November 2018
2 Reads

Hydrocortisone, Ascorbic Acid and Thiamine (HAT Therapy) for the Treatment of Sepsis. Focus on Ascorbic Acid.

Authors:
Paul E Marik

Nutrients 2018 Nov 14;10(11). Epub 2018 Nov 14.

Division of Pulmonary and Critical Care Medicine, Eastern Virginia Medical School, Norfolk, VA 23507, USA.

Sepsis is a devastating disease that carries an enormous toll in terms of human suffering and lives lost. Over 100 novel pharmacologic agents that targeted specific molecules or pathways have failed to improve the outcome of sepsis. Preliminary data suggests that the combination of Hydrocortisone, Ascorbic Acid and Thiamine (HAT therapy) may reduce organ failure and mortality in patients with sepsis and septic shock. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.3390/nu10111762DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6265973PMC
November 2018
12 Reads

Ehrlichiosis presenting as severe sepsis and meningoencephalitis in an immunocompetent adult.

JMM Case Rep 2018 Sep 27;5(9):e005162. Epub 2018 Jul 27.

Department of Pharmacy Practice and Science, University of Kentucky College of Pharmacy, Lexington, KY, USA.

Introduction: are obligate intracellular pathogens transmitted to vertebrates by ticks.

Case Presentation: We report the case of a 59-year-old man who presented to the University of Kentucky Albert B. Chandler Medical Center (Lexington, KY, USA) after being found fallen down in the woods. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1099/jmmcr.0.005162DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6230758PMC
September 2018
3 Reads

Emphysematous pyelonephritis in renal allograft related to antibody-mediated rejection: A case report and literature review.

Transpl Infect Dis 2019 Feb 4;21(1):e13026. Epub 2018 Dec 4.

Department of Transplant and Hepatobiliary Surgery, Henry Ford Hospital, Detroit, Michigan.

Emphysematous pyelonephritis (EPN) is a rare condition which can rapidly progress to sepsis and multiple organ failure with high mortality. We experienced a rare case of EPN in a renal allograft related to antibody-mediated rejection (AMR). The patient received a deceased donor kidney transplant due to end-stage renal disease secondary to diabetes mellitus. Read More

View Article

Download full-text PDF

Source
http://doi.wiley.com/10.1111/tid.13026
Publisher Site
http://dx.doi.org/10.1111/tid.13026DOI Listing
February 2019
17 Reads

Prognostic Factors Predicting Poor Outcome in Cancer Patients with Febrile Neutropenia in the Emergency Department: Usefulness of qSOFA.

J Oncol 2018 11;2018:2183179. Epub 2018 Oct 11.

Department of Emergency Medicine, Inha University School of Medicine, Incheon, Republic of Korea.

Background/aims: Febrile neutropenia is considered as one of the most important and potentially life-threatening oncologic emergencies, which requires prompt medical assessment and treatment with antibiotics. This was a single-center retrospective study that investigated the prognostic factors predicting poor outcome in patients with cancer who presented with febrile neutropenia at the emergency department (ED).

Methods: The medical records of patients diagnosed with febrile neutropenia in the ED from January 2014 to December 2017 were reviewed. Read More

View Article

Download full-text PDF

Source
https://www.hindawi.com/journals/jo/2018/2183179/
Publisher Site
http://dx.doi.org/10.1155/2018/2183179DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6201329PMC
October 2018
7 Reads

PICK1 Deficiency Induces Autophagy Dysfunction via Lysosomal Impairment and Amplifies Sepsis-Induced Acute Lung Injury.

Mediators Inflamm 2018 3;2018:6757368. Epub 2018 Oct 3.

Department of Anesthesiology, The First Affiliated Hospital of Wenzhou Medical University, Nanbaixiang, Wenzhou City, Zhejiang Province 325000, China.

Sepsis is a systemic inflammatory reaction caused by infection. Multiple organ failure ultimately leads to high morbidity and mortality. Unfortunately, therapies against these responses have been unsuccessful due to the insufficient underlying pathophysiological evidence. Read More

View Article

Download full-text PDF

Source
https://www.hindawi.com/journals/mi/2018/6757368/
Publisher Site
http://dx.doi.org/10.1155/2018/6757368DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6192133PMC
January 2019
8 Reads
3.240 Impact Factor

Laparoscopic extraction of gastric self-expandable metallic stent after migration in ileum: A case report.

Int J Surg Case Rep 2018 29;53:112-114. Epub 2018 Oct 29.

Department of General Surgery, Hôpital de Nivelles, Nivelles, Belgium.

Revisional surgery in bariatric patients can sometimes lead to life-threatening complications that need a fast diagnosis and treatment as well as a multidisciplinary approach. If left undiagnosed or untreated, this may lead to sepsis, multiple organ failure, and death. In this case report, we describe the management of a gastric perforation which occurred after conversion of a gastric banding to a sleeve gastrectomy. Read More

View Article

Download full-text PDF

Source
https://linkinghub.elsevier.com/retrieve/pii/S22102612183046
Publisher Site
http://dx.doi.org/10.1016/j.ijscr.2018.10.041DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6216075PMC
October 2018
9 Reads

Death related to Cedecea lapagei in a soft tissue bullae infection: a case report.

J Med Case Rep 2018 Nov 3;12(1):328. Epub 2018 Nov 3.

Faculty of Medicine, University of Colima, Colima, Mexico.

Background: Cedecea lapagei bacterium was discovered in 1977 but was not known to be pathogenic to humans until 2006. In the medical literature there are very few clinical case reports of Cedecea lapagei; none have reported a catastrophic death secondary to a soft tissue hemorrhagic bullae infection. As well as soft tissue infection, rare cases of pneumonia, urinary tract infections, peritonitis, osteomyelitis, bacteremia, and sepsis have been documented with the majority having good outcomes. Read More

View Article

Download full-text PDF

Source
https://jmedicalcasereports.biomedcentral.com/articles/10.11
Publisher Site
http://dx.doi.org/10.1186/s13256-018-1866-xDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6215343PMC
November 2018
21 Reads

[Blunt abdominal trauma causing acute pancreatitis: presentation of the case study].

Pan Afr Med J 2018 13;30:126. Epub 2018 Jun 13.

Service des Urgences Hôpital Régional de Kasserin, Tunisie.

Acute pancreatitis is a serious disease having a guarded prognosis. Its etiology involves either bladder or alcohol. Traumatic origin is extremely rare and it is often associated with other intra-abdominal lesions. Read More

View Article

Download full-text PDF

Source
http://www.panafrican-med-journal.com/content/article/30/126
Publisher Site
http://dx.doi.org/10.11604/pamj.2018.30.126.14675DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6201622PMC
November 2018
10 Reads

Sepsis caused by multidrug-resistant klebsiella pneumoniae infection in a 23-year-old burn patient: case report and literature review.

Ann Burns Fire Disasters 2018 Jun;31(2):113-117

Medical University of Vienna, Vienna, Austria.

Septic complications are a major problem in burn care. Infections caused by multidrug-resistant (MDR) Klebsiella pneumoniae strains represent a growing threat. In particular, Romania has seen rapidly increasing rates of MDR Klebsiella pneumoniae isolates in recent years. Read More

View Article

Download full-text PDF

Source
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6199020PMC
June 2018
2 Reads

Gender differences in trauma, shock and sepsis.

Mil Med Res 2018 10 26;5(1):35. Epub 2018 Oct 26.

Center for Surgical Research and Department of Surgery, University of Alabama at Birmingham, Birmingham, AL, 35294, USA.

Despite efforts in prevention and intensive care, trauma and subsequent sepsis are still associated with a high mortality rate. Traumatic injury remains the main cause of death in people younger than 45 years and is thus a source of immense social and economic burden. In recent years, the knowledge concerning gender medicine has continuously increased. Read More

View Article

Download full-text PDF

Source
https://mmrjournal.biomedcentral.com/articles/10.1186/s40779
Publisher Site
http://dx.doi.org/10.1186/s40779-018-0182-5DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6203206PMC
October 2018
16 Reads

Etiology of hyperglycemia in critically ill children and the impact of organ dysfunction.

Rev Bras Ter Intensiva 2018 Jul-Sept;30(3):286-293

Department of Pediatrics, Cairo University - Cairo, Egypt.

Objective: This study aimed to study the incidence of stress hyperglycemia in critically ill children and to investigate the etiological basis of the hyperglycemia based on homeostasis model assessment.

Methods: This was a prospective cohort study in one of the pediatric intensive care units of Cairo University, including 60 critically ill children and 21 healthy controls. Serum blood glucose, insulin, and C-peptide levels were measured within 24 hours of admission. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.5935/0103-507X.20180051DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6180474PMC
December 2018
2 Reads

Necrotizing Fasciitis Involving Spine: Unusual Medical Emergency for Spine Surgeon.

World Neurosurg 2019 Jan 12;121:124-126. Epub 2018 Oct 12.

Department of Surgery, Section of Orthopedic Surgery, University of Calgary, Alberta, Canada.

Background: Necrotizing fasciitis (NF) is a surgical diagnosis characterized by a rapidly progressive soft tissue infection, widespread tissue necrosis, and associated systemic illness. Friability of the superficial fascia, dishwater-gray exudate, and absence of pus are surgical characteristics of this diagnosis. Due to rapid progression of the infection, early recognition and aggressive surgical debridement are crucial to reduce mortality. Read More

View Article

Download full-text PDF

Source
https://linkinghub.elsevier.com/retrieve/pii/S18788750183232
Publisher Site
http://dx.doi.org/10.1016/j.wneu.2018.10.031DOI Listing
January 2019
11 Reads

The role of biomarkers of endothelial activation in predicting morbidity and mortality in patients with severe sepsis and septic shock in intensive care: A prospective observational study.

Thromb Res 2018 11 1;171:149-154. Epub 2018 Oct 1.

Emergency Department, Beijing Chao-yang Hospital, Capital Medical University, No. 8 Worker's Stadium South Road, Chao-yang District, Beijing 100020, China.

Introduction: Endothelial dysfunction plays an essential role in the pathogenesis of sepsis. The study aimed to illustrate the associations between the dynamic change (from day 1 to day 7) in biomarker concentration of endothelial dysfunction and outcomes in severe sepsis and septic shock in the intensive care unit (ICU).

Materials And Methods: We studied 102 patients enrolled in the Beijing Chao-yang Hospital affiliated with the Capital Medical University. Read More

View Article

Download full-text PDF

Source
https://linkinghub.elsevier.com/retrieve/pii/S00493848183055
Publisher Site
http://dx.doi.org/10.1016/j.thromres.2018.09.059DOI Listing
November 2018
11 Reads

Acute liver failure secondary to severe systemic disease from fatal hemophagocytic lymphohistiocytosis: Case report and systematic literature review.

World J Hepatol 2018 Sep;10(9):629-636

Department of Pathology, William Beaumont Hospital, Royal Oak, MI 48073, United States.

Aim: To systematically review liver disease associated with hemophagocytic lymphohistiocytosis (HLH), propose reasonable contraindications for liver transplantation for liver failure in HLH, and report an illustrative case.

Methods: Systematic review according to PRISMA guidelines of hepatic manifestations of HLH using computerized literature search PubMed of articles published since 1980 with keywords ("hemophagocytic lymphohistiocytosis" or "HLH") AND ("liver" or "hepatic"). Two authors independently performed literature search and incorporated articles into this review by consensus. Read More

View Article

Download full-text PDF

Source
http://www.wjgnet.com/1948-5182/full/v10/i9/629.htm
Publisher Site
http://dx.doi.org/10.4254/wjh.v10.i9.629DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6177573PMC
September 2018
3 Reads

Expression changes of autophagy-related proteins in AKI patients treated with CRRT and their effects on prognosis of adult and elderly patients.

Immun Ageing 2018 3;15:23. Epub 2018 Oct 3.

2Department of Nephrology, The First People's Hospital of Xuzhou, Xuzhou Municipal Hospital Affiliated to Xuzhou Medical University, Xuzhou, Jiangsu 221000 People's Republic of China.

Background: Sepsis is one of the common death factors in intensive care unit, which refers to the systemic inflammatory response syndrome caused by infection. It has many complications such as acute renal injury, shock, multiple organ dysfunction, and failure. The mortality of acute renal injury is the highest among the complications, which is a serious threat to the safety of patients and affects the quality of life. Read More

View Article

Download full-text PDF

Source
https://immunityageing.biomedcentral.com/articles/10.1186/s1
Publisher Site
http://dx.doi.org/10.1186/s12979-018-0128-5DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6169063PMC
October 2018
7 Reads

The role of co-administration of damage control surgery and vacuum-assisted closure in the treatment of perineal wounds.

Turk J Surg 2018 3;34(3):229-230. Epub 2018 Jan 3.

Department of General Surgery, Mustafa Kemal University School of Medicine, Hatay, Turkey.

Perineal wounds caused by high-kinetic-energy shotgun blasts have a high mortality risk because they are often accompanied by injuries of the anus, rectum, genitourinary system, and extremities. Mortality often results from hemorrhage in the early stage and from multiple organ failure caused by sepsis in the late stage. The primary step in the treatment of patients presenting with perineal wound and hemodynamic instability caused by severe hemorrhage is to control hemorrhage and contamination using damage control surgery. Read More

View Article

Download full-text PDF

Source
https://www.turkjsurg.com/abstract/1531/eng
Publisher Site
http://dx.doi.org/10.5152/turkjsurg.2017.3257DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6173606PMC
January 2018
7 Reads

Cardiovascular Parameters Associated With Troponin I as Indicators for 14-Day Mortality in Patients With Septic Shock.

Am J Med Sci 2018 Sep 1;356(3):244-253. Epub 2018 Jun 1.

Division of Pulmonary and Critical Care Medicine, Department of Internal Medicine, Taipei Tzu Chi Hospital, Buddhist Tzu Chi Medical Foundation, New Taipei, Taiwan; School of Medicine, Tzu Chi University, Hualien, Taiwan. Electronic address:

Background: Troponin I is better than other troponin isoforms for monitoring cardiocyte damage, and correlates with sepsis-related mortality. However, hemodynamic factors possibly interact with cardiac function to affect mortality in sepsis. Thus, this study used parameters from pulse-induced contour cardiac output (PiCCO) to investigate the possibility. Read More

View Article

Download full-text PDF

Source
https://linkinghub.elsevier.com/retrieve/pii/S00029629183018
Publisher Site
http://dx.doi.org/10.1016/j.amjms.2018.05.008DOI Listing
September 2018
9 Reads

Burkitt lymphoma of the ovaries mimicking sepsis: a case report and review of the literature.

J Med Case Rep 2018 Oct 5;12(1):285. Epub 2018 Oct 5.

Intensive Care Unit, Tzaneio General Hospital of Piraeus, Dodonis 26, 13451, Kamatero, Greece.

Background: It is not unusual for systemic diseases to mimic sepsis and, in any case, the clinician should thoroughly investigate this possibility.

Case Presentation: We present the case of a 21-year-old Greek woman who presented to the Intensive Care Unit of our hospital with severe septic shock - multiple organ failure as a result of a suspected gynecological infection of the ovaries. An immediate improvement of her clinical condition in combination with strong clinical suspicion and negative cultures led to the differential diagnosis of diseases other than sepsis. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1186/s13256-018-1828-3DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6172811PMC
October 2018
4 Reads

Mortality after pancreaticoduodenectomy: assessing early and late causes of patient death.

J Surg Res 2018 Nov 27;231:304-308. Epub 2018 Jun 27.

Department of Surgery, University of Virginia, Charlottesville, Virginia; Surgery Outcomes Research Center, University of Virginia, Charlottesville, Virginia; Division of Surgical Oncology, University of Virginia, Charlottesville, Virginia. Electronic address:

Background: Safety of pancreaticoduodenectomy has improved significantly in the past 3 decades. Current inpatient and 30-d mortality rates are low. However, incidence and causes of 90-d and 1-y mortality are poorly defined and largely unexplored. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1016/j.jss.2018.05.075DOI Listing
November 2018
3 Reads