5,679 results match your criteria Multisystem Organ Failure of Sepsis


Persistently Elevated Glucagon-Like Peptide 1 Levels Among Critically-Ill Surgical Patients After Sepsis and Development of Chronic Critical Illness and Dismal Long-Term Outcomes.

J Am Coll Surg 2019 Apr 13. Epub 2019 Apr 13.

Department of Surgery, University of Florida, Gainsville, FL.

Background: Glucagon-like peptide-1 (GLP-1) is a gut derived incretin hormone that stimulates insulin secretion, cellular glucose uptake and has immune-regulatory functions. GLP-1 is markedly altered following trauma and sepsis, but the implications remain unclear.

Study Design: We performed an analysis of a prospective, longitudinal cohort study of critically-ill surgical patients with sepsis. Read More

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http://dx.doi.org/10.1016/j.jamcollsurg.2019.04.014DOI Listing

Influenza-associated septic shock accompanied by septic cardiomyopathy that developed in summer and mimicked fulminant myocarditis.

Acute Med Surg 2019 Apr 10;6(2):192-196. Epub 2019 Feb 10.

The Emergency and Critical Care Center Mie University Hospital Tsu Mie Japan.

Case: Fulminant myocarditis (FM) and septic cardiomyopathy (SC) are two different disease entities, and distinction between them is important. A 34-year-old man had refractory shock, multiple organ failure, and elevation of cardiogenic markers. Echocardiogram showed tachycardia with extended ST elevation, and a rapid test for influenza A virus was positive. Read More

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https://onlinelibrary.wiley.com/doi/abs/10.1002/ams2.394
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http://dx.doi.org/10.1002/ams2.394DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6442530PMC
April 2019
6 Reads

First Experience with Extracorporeal Membrane Oxygenation in Iran, under Difficult Conditions.

J Tehran Heart Cent 2018 Oct;13(4):166-172

Tracheal Diseases Research Center, National Research Institute of Tuberculosis and Lung Diseases (NRITLD), Shahid Beheshti University of Medical Sciences, Tehran, Iran.

Extracorporeal membrane oxygenation (ECMO) provides hemodynamic and oxygenation support in critical conditions. The commencement of this modality in Iran coincided with severe economic constraints across Iran. This retrospective study was performed in Masih Daneshvari Medical Center from 2010 to 2015, during which period, sanction-related limitations in the import of equipment prompted us to integrate a Medtronic or Stöckert head pump console into a Maquet ECMO Oxygenator so as to sustain the ECMO program. Read More

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http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6450813PMC
October 2018
1 Read

Targeting Complement Pathways in Polytrauma- and Sepsis-Induced Multiple-Organ Dysfunction.

Front Immunol 2019 21;10:543. Epub 2019 Mar 21.

Institute for Clinical and Experimental Trauma-Immunology, University Hospital of Ulm, Ulm, Germany.

Exposure to traumatic or infectious insults results in a rapid activation of the complement cascade as major fluid defense system of innate immunity. The complement system acts as a master alarm system during the molecular danger response after trauma and significantly contributes to the clearance of DAMPs and PAMPs. However, depending on the origin and extent of the damaged macro- and micro -milieu, the complement system can also be either excessively activated or inhibited. Read More

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https://www.frontiersin.org/article/10.3389/fimmu.2019.00543
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http://dx.doi.org/10.3389/fimmu.2019.00543DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6437067PMC
March 2019
4 Reads

[Risk factors of surgical treatment of acute aortic dissection type A (in Russian only)].

Khirurgiia (Mosk) 2019 (3):15-20

Pirogov Russian National Research Medical University, Moscow, Russia.

Aim: To evaluate risk factors of surgical treatment of acute aortic dissection type A.

Material And Methods: Retrospective analysis included 100 patients with acute aortic dissection type A who underwent surgery in 2007-2017. Patients were divided into 2 groups: group I (survivors, n=79) and group II (unfavorable outcomes, n=21). Read More

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http://dx.doi.org/10.17116/hirurgia201903115DOI Listing
January 2019

Acute Lymphoblastic Leukemia with Malignant Hypercalcemia: A Case Report.

Am J Case Rep 2019 Mar 28;20:402-405. Epub 2019 Mar 28.

Department of Pediatrics, University of Medicine and Pharmacy "Iuliu Hatieganu", Cluj-Napoca, Romania.

BACKGROUND Malignant hypercalcemia is a rare finding in the pediatric population, even more rare in hematological malignancies, such as leukemia. CASE REPORT We present a case of a 6-year-old female patient who was diagnosed with acute lymphoblastic leukemia, with secondary hypercalcemia. She started chemotherapy following the IC-BFM ALL2002 protocol with simultaneous calcitonin, diuretics and aggressive hydration for hypercalcemia, and went into complete remission after the induction therapy. Read More

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http://dx.doi.org/10.12659/AJCR.914303DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6452782PMC
March 2019
1 Read

Laparoscopy-induced severe renal failure after appendectomy.

J Surg Case Rep 2019 Mar 21;2019(3):rjz079. Epub 2019 Mar 21.

Colorectal Surgery Department, University Hospital Donostia, San Sebastian, Spain.

Laparoscopy has gained importance in the abdominal emergency surgery field. Acute appendicitis is one of the major indications for emergency surgery, being laparoscopy the gold standard approach. We report a case of a 39-years-old female presenting with acute kidney injury (AKI) after laparoscopy. Read More

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http://dx.doi.org/10.1093/jscr/rjz079DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6428156PMC
March 2019
1 Read

A Retrospective Analysis of Nonocclusive Mesenteric Ischemia in Medical and Surgical ICU Patients: Clinical Data on Demography, Clinical Signs, and Survival.

J Intensive Care Med 2019 Mar 25:885066619837911. Epub 2019 Mar 25.

4 Department of Nephrology and Hypertension, Hannover Medical School, Hannover, Germany.

Background:: To analyze demography, clinical signs, and survival of intensive care patients diagnosed with nonocclusive mesenteric ischemia (NOMI) and to evaluate the effect of a local intra-arterial prostaglandin therapy.

Methods:: Retrospective observational study screening 455 intensive care patients with acute arterial mesenteric perfusion disorder in a tertiary care hospital within the past 8 years. Lastly, 32 patients with NOMI were enrolled, of which 11 received local intra-arterial prostaglandin therapy. Read More

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http://dx.doi.org/10.1177/0885066619837911DOI Listing
March 2019
3 Reads

Vagus Nerve Stimulation Attenuates Multiple Organ Dysfunction in Resuscitated Porcine Progressive Sepsis.

Crit Care Med 2019 Mar 25. Epub 2019 Mar 25.

Department of Physiology, Faculty of Medicine in Pilsen, Charles University, Pilsen, Czech Republic.

Objectives: To investigate the potential benefits of vagus nerve stimulation in a clinically-relevant large animal model of progressive sepsis.

Design: Prospective, controlled, randomized trial.

Setting: University animal research laboratory. Read More

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http://dx.doi.org/10.1097/CCM.0000000000003714DOI Listing
March 2019
1 Read

[Five patients with severe burns complicated by fungal infection].

Zhonghua Shao Shang Za Zhi 2019 Mar;35(3):221-223

Department of Burns, Hwa Mei Hospital, University of Chinese Academy of Sciences, Ningbo 315010, China.

From June to November 2016, 5 patients with severe burns were admitted to our unit. Broad-spectrum antibiotic and fluconazole were used on patients as earlier empirical anti-infection therapy of bacteria and fungi. Seven to twenty-one days after injury, 5 patients developed fungal infection. Read More

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http://dx.doi.org/10.3760/cma.j.issn.1009-2587.2019.03.011DOI Listing
March 2019
1 Read

Cardiovascular Insufficiency, Abdominal Sepsis, and Patients' Age Are Associated with Decreased Paraoxonase-1 (PON1) Activity in Critically Ill Patients with Multiple Organ Dysfunction Syndrome (MODS).

Dis Markers 2019 11;2019:1314623. Epub 2019 Feb 11.

Department of Medical Biochemistry, Wroclaw Medical University, Wroclaw, Poland.

Oxidative stress and uncontrolled inflammation are hallmarks of sepsis, leading to organ failure and death. As demonstrated in animal studies, oxidative stress can be alleviated by antioxidant therapies. Paraoxonase-1 (PON1) is a serum-based antioxidant, anti-inflammatory agent, detoxifier, and quorum-sensing factor found to be a prognostic marker in sepsis. Read More

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http://dx.doi.org/10.1155/2019/1314623DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6388350PMC
February 2019
4 Reads

Geriatric urinary tract infections: The value of laboratory parameters in estimating the need for bacteremia and Intensive Care Unit.

Pak J Med Sci 2019 Jan-Feb;35(1):215-219

Department of Infectious Diseases and Clinical Microbiology, Faculty of Medicine, Firat University, Elazig, Turkey.

Objective: We investigated the geriatric patients diagnosed as urinary tract infection and evaluated the effects of white blood cell (WBC), neutrophil count, platelet, mean platelet volume (MPV), red cell distribution width (RDW), total bilirubin, direct bilirubin, creatine, albumin, erythrocyte sedimentation rate, C-reactive protein, and neutrophil/lymphocyte ratio parameters on estimating the need for bacteremia and intensive care (IC) for the patients with pyelonephritis.

Methods: Between 2016-2017, a total number of 188 patients aged 65 years and above were retrospectively evaluated at the infectious diseases clinic.

Results: The 124 (66%) of the patients were male and 64 (34%) were female. Read More

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http://dx.doi.org/10.12669/pjms.35.1.97DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6408671PMC
March 2019
1 Read

Efficacy of Coupled Plasma Filtration Adsorption in Treating Patients with Severe Intra-Abdominal Infection: A Retrospective Study.

J Laparoendosc Adv Surg Tech A 2019 Mar 15. Epub 2019 Mar 15.

Department of General Surgery, Jinling Clinical College of Nanjing Medical University, Nanjing, China.

Background: Coupled plasma filtration adsorption (CPFA) is an extracorporeal treatment based on plasma filtration associated with an adsorbent cartridge and hemofiltration. CPFA is able to remove inflammatory mediators and it has been used to treat severe sepsis and multiple organ dysfunction. Limited experience exists on the use of CPFA in treating intra-abdominal infection (IAI). Read More

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http://dx.doi.org/10.1089/lap.2018.0792DOI Listing
March 2019
1 Read

Consumptive coagulopathy is associated with organ dysfunction during PICS.

Am J Physiol Lung Cell Mol Physiol 2019 Mar 6. Epub 2019 Mar 6.

Surgery, University of Cincinnati, Department of Surgery, United States.

Patients who survive the acute phase of sepsis can progress to persistent inflammation, immunosuppression, and catabolism syndrome (PICS). Although sepsis is characterized by early hypercoagulability and delayed hypocoagulability, coagulopathy during chronic critical illness is not fully understood. The objective of this study was to determine whether sepsis-induced PICS is associated with coagulation abnormalities. Read More

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http://dx.doi.org/10.1152/ajplung.00521.2018DOI Listing
March 2019
1 Read

Acute and chronic remote ischemic conditioning attenuate septic cardiomyopathy, improve cardiac output, protect systemic organs, and improve mortality in a lipopolysaccharide-induced sepsis model.

Basic Res Cardiol 2019 03 5;114(3):15. Epub 2019 Mar 5.

Cincinnati Children'S Hospital Medical Center, Heart Institute, 3333 Burnet Avenue, Cincinnati, OH, 45229-3026, USA.

Remote ischemic conditioning (RIC) is acutely cardioprotective in ischemia-reperfusion injury. We aimed to evaluate the effect of RIC on septic cardiomyopathy and associated multi-organ failure in a lipopolysaccharide (LPS)-induced sepsis mouse model. Balb/c mice were divided into sham, LPS, and LPS + RIC groups. Read More

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http://dx.doi.org/10.1007/s00395-019-0724-3DOI Listing
March 2019
1 Read

Evaluation of myocardial function in neonatal sepsis using tissue Doppler imaging.

J Matern Fetal Neonatal Med 2019 Mar 5:1-5. Epub 2019 Mar 5.

a Pediatrics Department , Beni-Suef University , Beni Suef , Egypt.

Background: Neonatal sepsis is an important cause of neonatal morbidity and mortality especially in developing countries. Cardiac dysfunction is a major complication of severe sepsis and occurs as a part of multiple organ failure.

Objective: To asses right and left ventricular functions in neonates with sepsis using tissue Doppler imaging (TDI). Read More

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http://dx.doi.org/10.1080/14767058.2019.1583739DOI Listing
March 2019
4 Reads

Personalized medicine with IgGAM compared with standard of care for treatment of peritonitis after infectious source control (the PEPPER trial): study protocol for a randomized controlled trial.

Trials 2019 Mar 4;20(1):156. Epub 2019 Mar 4.

Department of Intensive Care and Intermediate Care, University Hospital RWTH Aachen, Pauwelsstr.30, 52074, Aachen, Germany.

Background: Peritonitis is responsible for thousands of deaths annually in Germany alone. Even source control (SC) and antibiotic treatment often fail to prevent severe sepsis or septic shock, and this situation has hardly improved in the past two decades. Most experimental immunomodulatory therapeutics for sepsis have been aimed at blocking or dampening a specific pro-inflammatory immunological mediator. Read More

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http://dx.doi.org/10.1186/s13063-019-3244-4DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6399861PMC
March 2019
6 Reads

Human-induced pluripotent stem cells derived hematopoietic progenitor cells for treatment of hematopoietic failure among trauma hemorrhagic shock patients.

J Clin Orthop Trauma 2019 Mar-Apr;10(2):269-273. Epub 2018 Apr 22.

Department of Emergency Medicine, JPN Apex Trauma Centre, AIIMS, New Delhi, 110029, India.

Hematopoietic failure (HF) has been observed in trauma hemorrhagic shock (T/HS) patients. Multiple factors are involved. Elevated serum levels of cytokines, catecholamine, granulocyte colony stimulating factor, peripheral blood hematopoietic progenitor cells (HPCs) and decreased expression of erythropoietin receptor are associated with HF among T/HS. Read More

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http://dx.doi.org/10.1016/j.jcot.2018.04.009DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6383080PMC
April 2018
2 Reads

Inhibition of contact-mediated activation of factor XI protects baboons against -induced organ damage and death.

Blood Adv 2019 Feb;3(4):658-669

Cardiovascular Biology Research Program, Oklahoma Medical Research Foundation, Oklahoma City, OK.

infections can produce systemic bacteremia and inflammation in humans, which may progress to severe sepsis or septic shock, even with appropriate antibiotic treatment. Sepsis may be associated with disseminated intravascular coagulation and consumptive coagulopathy. In some types of mouse infection models, the plasma coagulation protein factor XI (FXI) contributes to the pathogenesis of sepsis. Read More

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http://dx.doi.org/10.1182/bloodadvances.2018029983DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6391670PMC
February 2019
11 Reads

Sepsis Induced by Cecal Ligation and Puncture.

Authors:
Wei Gong Haitao Wen

Methods Mol Biol 2019 ;1960:249-255

Department of Microbial Infection and Immunity, The Ohio State University College of Medicine, Columbus, OH, USA.

Despite advances in intensive care unit interventions, including the use of specific antibiotics and anti-inflammation treatment, sepsis with concomitant multiple organ failure is the most common cause of death in many acute care units. In order to understand the mechanisms of clinical sepsis and develop effective therapeutic modalities, there is a need to use effective experimental models that faithfully replicate what occurs in patients with sepsis. Several models are commonly used to study sepsis, including intravenous endotoxin challenge, injection of live organisms into the peritoneal cavity, establishing abscesses in the extremities, and the induction of experimental polymicrobial peritonitis via cecal ligation and puncture (CLP). Read More

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http://dx.doi.org/10.1007/978-1-4939-9167-9_22DOI Listing
January 2019
1 Read

Changes in the temporal distribution of in-hospital mortality in severely injured patients-An analysis of the TraumaRegister DGU.

PLoS One 2019 22;14(2):e0212095. Epub 2019 Feb 22.

Department of Trauma Surgery, Technical University Munich, Hospital Rechts der Isar, Munich, Germany.

Background: The temporal distribution of trauma mortality has been classically described as a trimodal pattern with an immediate, early and late peak. In modern health care systems this time distribution has changed.

Methods: Data from the TraumaRegister DGU was analysed retrospectively. Read More

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http://journals.plos.org/plosone/article?id=10.1371/journal.pone.0212095PLOS
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6386341PMC
February 2019
2 Reads

Mitochondrial quality control mechanisms as potential therapeutic targets in sepsis-induced multiple organ failure.

J Mol Med (Berl) 2019 Apr 21;97(4):451-462. Epub 2019 Feb 21.

Emergency Department, The First Affiliated Hospital of Wenzhou Medical University, Wenzhou, People's Republic of China.

Sepsis is a dysregulated response to severe infection characterized by life-threatening organ failure and is the leading cause of mortality worldwide. Multiple organ failure is the central characteristic of sepsis and is associated with poor outcome of septic patients. Ultrastructural damage to the mitochondria and mitochondrial dysfunction are reported in sepsis. Read More

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http://dx.doi.org/10.1007/s00109-019-01756-2DOI Listing
April 2019
7 Reads

Hemodynamic consequences of intravenously given E. coli suspension: observations in a fulminant sepsis model in pigs, a descriptive case-control study.

Eur J Med Res 2019 Feb 13;24(1):11. Epub 2019 Feb 13.

Department of Anesthesiology and Intensive Care, Faculty of Medicine, University of Debrecen, Nagyerdei krt 98, Debrecen, 4032, Hungary.

Background: The aim of the present work was to assess systemic hemodynamic changes using PiCCo monitoring in a porcine model of E. coli-induced fulminant sepsis.

Methods: Thirty-one healthy female Hungahib pigs were randomly assigned into control (n = 15) or septic groups (n = 16). Read More

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http://dx.doi.org/10.1186/s40001-019-0372-yDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6373147PMC
February 2019
1 Read

Outcome of pediatric cardiac surgery and predictors of major complication in a developing country.

Ann Pediatr Cardiol 2019 Jan-Apr;12(1):38-44

Integrated Cardiac Centre, Dr. Cipto Mangunkusumo Hospital, Jakarta, Indonesia.

Background: Evaluating outcome and identifying predictors of major complications among children undergoing cardiac surgery are essential to improve care. We evaluated short-term outcomes of postcardiac surgery and predictors of major complications in a national referral hospital in Indonesia.

Methods: A prospective cohort study was conducted from April 2014 to March 2015 on all children undergoing cardiac surgery. Read More

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http://dx.doi.org/10.4103/apc.APC_146_17DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6343386PMC
February 2019
7 Reads

Delayed Antibiotic Therapy and Organ Dysfunction in Critically Ill Septic Patients in the Emergency Department.

J Clin Med 2019 Feb 8;8(2). Epub 2019 Feb 8.

Department of Emergency Medicine, Samsung Medical Center, Sungkyunkwan University School of Medicine, Gangnam-gu, Seoul 06351, Korea.

Background: We investigated the effect of antibiotic timing on outcomes based on changes in surrogate markers of organ failure, including platelet, serum bilirubin, serum creatinine levels, and the PaO₂/FiO₂ (P/F) ratio.

Methods: This was a single-center, retrospective observational study of critically ill septic patients who presented to the emergency department (ED). The study period extended from August 2008 to September 2016. Read More

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http://dx.doi.org/10.3390/jcm8020222DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6406307PMC
February 2019
5 Reads

A case report of community-acquired Pseudomonas aeruginosa pneumonia complicated with MODS in a previously healthy patient and related literature review.

BMC Infect Dis 2019 Feb 8;19(1):130. Epub 2019 Feb 8.

Department of Critical Care Medicine, Shanghai General Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai, Republic of China.

Background: Pseudomonas aeruginosa is an unusual pathogen in community-acquired pneumonia, especially in previously healthy adults, but often indicates poor prognosis.

Case Presentation: We report a previously healthy patient who developed severe community-acquired pneumonia (CAP) caused by P. aeruginosa. Read More

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http://dx.doi.org/10.1186/s12879-019-3765-1DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6368713PMC
February 2019
3 Reads

Modulation of the sigma-1 receptor-IRE1 pathway is beneficial in preclinical models of inflammation and sepsis.

Sci Transl Med 2019 Feb;11(478)

Center for Brain Immunology and Glia, Department of Neuroscience, School of Medicine, University of Virginia, Charlottesville, VA 22908, USA.

Sepsis is an often deadly complication of infection in which systemic inflammation damages the vasculature, leading to tissue hypoperfusion and multiple organ failure. Currently, the standard of care for sepsis is predominantly supportive, with few therapeutic options available. Because of increased sepsis incidence worldwide, there is an urgent need for discovery of novel therapeutic targets and development of new treatments. Read More

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http://dx.doi.org/10.1126/scitranslmed.aau5266DOI Listing
February 2019
1 Read

Gender Disparities in Trauma Care: How Sex Determines Treatment, Behavior, and Outcome.

Anesthesiol Clin 2019 Mar 27;37(1):107-117. Epub 2018 Nov 27.

Acute Care Surgery [Trauma, Burn, Critical Care, Emergency Surgery], Department of Surgery, Trauma and Surgical Critical Care, University of Michigan Health System, University Hospital, Room 1C340, 1500 East Medical Center Drive, Ann Arbor, MI 48109-5033, USA.

Trauma data bank and other research reveal sex disparities in trauma care. Risk-taking behaviors leading to traumatic injury have been associated with sex, menstrual cycle timing, and cortisol levels. Trauma patient treatment stratified by sex reveals differences in access to services at trauma centers as well as specific treatments, such as venous thromboembolism prophylaxis and massive transfusion component ratios. Read More

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http://dx.doi.org/10.1016/j.anclin.2018.09.007DOI Listing
March 2019
1 Read

[Staphylococcal toxic shock syndrome should be considered in the event of diffuse erythema with fever and shock].

Ann Dermatol Venereol 2019 Jan 25. Epub 2019 Jan 25.

Service de dermatologie-infectiologie, CHI Fréjus Saint-Raphaël, 240, avenue de Saint-Lambert, 83600 Fréjus, France.

Background: Toxic shock syndrome (TSS) was first described by Todd in 1978. The relevant Lancet publication reported 7 cases of children with fever, exanthema, hypotension and diarrhoea associated with multiple organ failure. An association between TSS and use of hyper-absorbent tampons in menstruating women was discovered in the 1980s. Read More

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http://dx.doi.org/10.1016/j.annder.2018.12.002DOI Listing
January 2019
3 Reads

A case report of a child with sepsis induced multiorgan failure and massive complement consumption treated with a short course of Eculizumab: A case of crosstalk between coagulation and complement?

Medicine (Baltimore) 2019 Jan;98(4):e14105

University Hospital Centre Zagreb, Kispaticeva, Zagreb.

Rationale: This article describes a child with a life-threatening multiorgan failure with disseminated intravascular coagulation (DIC) and massive complement consumption. To our knowledge this therapeutic approach was for the first time effectively applied in a pediatric patient.

Patient Concerns: A 14-month-old boy was presented with a severe, rapidly progressing, life-threatening disease because of sudden onset of fever, hemathemesis, hematuria, and bloody diarrhoea alongside fast spreading hematomas and general corporeal edema. Read More

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http://dx.doi.org/10.1097/MD.0000000000014105DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6358330PMC
January 2019
3 Reads

Comparison of Various Severity Assessment Scoring Systems in Patients with Sepsis in a Tertiary Care Teaching Hospital.

Indian J Crit Care Med 2018 Dec;22(12):842-845

Department of Pharmacy Practice, Manipal College of Pharmaceutical Sciences, Manipal, Karnataka, India.

Background: Sepsis is a complex condition defined by the systemic response to infection. Severity assessment scoring systems are used to aid the physician in deciding whether aggressive treatment is needed or not. In this study, various severity assessment scoring systems, namely Acute Physiology and Chronic Health Evaluation II (APACHE II), Rapid Emergency Medicine Score (REMS), Sequential Organ Failure Assessment (SOFA), Multiple Organ Dysfunction Score (MODS), Predisposition, Infection, Response, and Organ Dysfunction (PIRO), and Mortality in Emergency Department Sepsis (MEDS), were compared to assess their sensitivity and specificity. Read More

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http://www.ijccm.org/text.asp?2018/22/12/842/247745
Publisher Site
http://dx.doi.org/10.4103/ijccm.IJCCM_322_18DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6311975PMC
December 2018
18 Reads

Circulating histone H3 levels in septic patients are associated with coagulopathy, multiple organ failure, and death: a single-center observational study.

Thromb J 2019 14;17. Epub 2019 Jan 14.

1Department of Emergency and Intensive Care Medicine, Kagoshima University Graduate School of Medical and Dental Sciences, 8-35-1 Sakuragaoka, Kagoshima, 890-8544 Japan.

Background: Nuclear histone proteins are released into the extracellular space, and act as major mediators of coagulopathy and remote organ failure in septic animals. However, the circulating histone levels in septic patients have not been precisely quantified.

Methods: Using a novel enzyme-linked immunosorbent assay for histone H3 detection, we measured the serum histone H3 levels in 85 patients admitted to the intensive care unit because of infectious diseases. Read More

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http://dx.doi.org/10.1186/s12959-018-0190-4DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6330748PMC
January 2019
4 Reads

IMPACT probability of poor outcome and plasma cytokine concentrations are associated with multiple organ dysfunction syndrome following traumatic brain injury.

J Neurosurg 2019 Jan 11:1-7. Epub 2019 Jan 11.

Departments of1Neurosurgery and.

OBJECTIVETraumatic brain injury (TBI) is a major cause of morbidity and mortality. Multiple organ dysfunction syndrome (MODS) occurs frequently after TBI and independently worsens outcome. The present study aimed to identify potential admission characteristics associated with post-TBI MODS. Read More

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http://dx.doi.org/10.3171/2018.8.JNS18676DOI Listing
January 2019
9 Reads

Mitochondrial Function in the Kidney and Heart, but not the Brain, is Mainly Altered in an Experimental Model of Endotoxaemia.

Shock 2019 Jan 9. Epub 2019 Jan 9.

Latvian Institute of Organic Synthesis, Aizkraukles Str. 21, Riga, LV-1006, Latvia.

Significant impairments in mitochondrial function are associated with the development of multi-organ failure in sepsis/endotoxaemia, but the data on the dynamics of simultaneous mitochondrial impairment in multiple organs are limited. The aim of this study was to evaluate the changes in heart, brain and kidney mitochondrial function in an experimental model of lipopolysaccharide (LPS)-induced endotoxaemia.Samples were collected 4 and 24 h after single injection of LPS (10 mg/kg) in mice. Read More

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http://dx.doi.org/10.1097/SHK.0000000000001315DOI Listing
January 2019
2 Reads

Vancomycin dosing, monitoring and toxicity: Critical review of the clinical practice.

Clin Exp Pharmacol Physiol 2019 Jan 9. Epub 2019 Jan 9.

Botucatu School of Medicine, University São Paulo State-UNESP, Botucatu, Brazil.

Vancomycin is an antibiotic used in the treatment of infections caused by multidrug-resistant Gram-positive bacteria, especially methicillin-resistant Staphylococcus aureus. In the last decades, vancomycin has been widely used in hospital environments due to the increasing incidence of sepsis and septic shock. Sepsis may lead to multiple organ failure; it is considered a risk factor for the development of acute kidney injury (AKI), with an overall mortality rate of around 45%, which can reach the surprising rate of 70% with the combination of AKI and sepsis. Read More

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http://dx.doi.org/10.1111/1440-1681.13066DOI Listing
January 2019
5 Reads

Chemically synthesized Secoisolariciresinol diglucoside (LGM2605) improves mitochondrial function in cardiac myocytes and alleviates septic cardiomyopathy.

J Mol Cell Cardiol 2019 Feb 3;127:232-245. Epub 2019 Jan 3.

Center for Translational Medicine and Department of Pharmacology, Lewis Katz School of Medicine, Temple University, Philadelphia, PA, USA. Electronic address:

Sepsis is the overwhelming systemic immune response to infection, which can result in multiple organ dysfunction and septic shock. Myocardial dysfunction during sepsis is associated with advanced disease and significantly increased in-hospital mortality. Our group has shown that energetic failure and excess reactive oxygen species (ROS) generation constitute major components of myocardial dysfunction in sepsis. Read More

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http://dx.doi.org/10.1016/j.yjmcc.2018.12.016DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6359996PMC
February 2019
4 Reads

Variability of mitochondrial respiration in relation to sepsis-induced multiple organ dysfunction.

Physiol Res 2018 Dec;67(Supplementum 4):S577-S592

Institute of Physiology, Faculty of Medicine in Plzeň, Charles University, Plzeň, Czech Republic.

Ample experimental evidence suggests that sepsis could interfere with any mitochondrial function; however, the true role of mitochondrial dysfunction in the pathogenesis of sepsis-induced multiple organ dysfunction is still a matter of controversy. This review is primarily focused on mitochondrial oxygen consumption in various animal models of sepsis in relation to human disease and potential sources of variability in experimental results documenting decrease, increase or no change in mitochondrial respiration in various organs and species. To date, at least three possible explanations of sepsis-associated dysfunction of the mitochondrial respiratory system and consequently impaired energy production have been suggested: 1. Read More

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December 2018
1 Read

Posterior reversible encephalopathy syndrome (PRES) and infection: a systematic review of the literature.

Neurol Sci 2019 Jan 2. Epub 2019 Jan 2.

Department of Biomedical Sciences and Morphological and Functional Imaging, University of Messina, Policlinico "G. Martino" Via Consolare Valeria 1, 98100, Messina, Italy.

Posterior reversible encephalopathy syndrome (PRES) is an encephalopathy characterized by a rapid onset of symptoms including headache, seizures, confusion, blurred vision, and nausea associated with a typical magnetic resonance imaging appearance of reversible subcortical vasogenic edema prominent and not exclusive of parieto-occipital lobes. Vasogenic edema is caused by a blood-brain barrier leak induced by endothelial damage or a severe arterial hypertension exceeding the limits of cerebral blood flow autoregulation. Although the exact pathophysiological mechanism is still unclear, frequent conditions that may induce PRES include severe hypertension, eclampsia/pre-eclampsia, acute kidney diseases and failure, immunosuppressive therapy, solid organ, or bone marrow transplantation. Read More

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http://dx.doi.org/10.1007/s10072-018-3651-4DOI Listing
January 2019
2 Reads

Acute-on-chronic liver failure in children with biliary atresia awaiting liver transplantation.

Pediatr Transplant 2019 03 30;23(2):e13339. Epub 2018 Dec 30.

Paediatric Liver, Gastroenterology and Nutrition Centre, King's College Hospital, London, UK.

Objectives: Acute-on-chronic liver failure (ACLF) is an acute decompensation of cirrhosis complicated by other organ failure and is associated with increased mortality and morbidity. ACLF has not been studied in children with biliary atresia (BA), which is the commonest indication for pediatric liver transplantation (LT) worldwide. This study aims to evaluate ACLF and outcomes in children with BA while awaiting deceased donor LT. Read More

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http://dx.doi.org/10.1111/petr.13339DOI Listing
March 2019
22 Reads

Platelet Glycoprotein VI Haplotypes and the Presentation of Paediatric Sepsis.

Thromb Haemost 2019 Mar 31;119(3):431-438. Epub 2018 Dec 31.

Department of Physiology and Biophysics, University of Arkansas for Medical Sciences, Little Rock, Arkansas, United States.

Sepsis triggers a complex series of pathophysiologic events involving inflammatory responses and coagulation abnormalities. While circulating blood platelets are well-characterized for their contributions to coagulation, increasingly platelet-dependent effects on inflammation are being recognized. Here, we focus on the platelet membrane receptor, glycoprotein VI (GPVI), and its role in platelet microparticle (pMP) release. Read More

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http://dx.doi.org/10.1055/s-0038-1676794DOI Listing
March 2019
3 Reads

Potential Risk Factors for In-Hospital Mortality in Patients with Moderate-to-Severe Blunt Multiple Trauma Who Survive Initial Resuscitation.

Emerg Med Int 2018 22;2018:6461072. Epub 2018 Nov 22.

Department of Infectious Disease and Clinical Microbiology, Inonu University, School of Medicine, Malatya, Turkey.

Introduction: The aim was to identify risk factors that influence in-hospital mortality for patients with moderate-to-severe blunt multiple trauma (BMT) who survive initial resuscitation.

Methods: The prospective study involved 195 adult patients with BMT who were admitted to a referral hospital's emergency department (ED) between May 1, 2015, and May 31, 2016.

Results: Forty-three (22%) of the 195 patients died in hospital. Read More

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http://dx.doi.org/10.1155/2018/6461072DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6282151PMC
November 2018
2 Reads

Ivabradine: Evidence and current role in cardiovascular diseases and other emerging indications.

Indian Heart J 2018 Dec 20;70 Suppl 3:S435-S441. Epub 2018 Aug 20.

Dr. Newale Health Centre, Navi Mumbai, 400614, India. Electronic address:

Increased heart rate (HR) is associated with deleterious effects on several disease conditions. Chronic heart failure (CHF) is one of the cardiovascular diseases with recurrent hospitalization burden and an ongoing drain on health-care expenditure. Despite advancement in medicine, management of CHF remains a challenge to health-care providers. Read More

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http://dx.doi.org/10.1016/j.ihj.2018.08.008DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6309574PMC
December 2018
3 Reads

A case report and literature review: previously excluded tuberculosis masked by amiodarone induced lung injury.

BMC Pharmacol Toxicol 2018 Dec 29;19(1):88. Epub 2018 Dec 29.

Institute of Physiology and Pharmacology, Lithuanian University of Health Sciences, A. Mickeviciaus str. 9, 44307, Kaunas, LT, Lithuania.

Background: Amiodarone is an antiarrhythmic drug which is used to treat and prevent several dysrhythmias. This includes ventricular tachycardia and fibrillation, wide complex tachycardia, as well as atrial fibrillation (AF) and paroxysmal supraventricular tachycardia. Amiodarone may prove to be the agent of choice where the patient is hemodynamically unstable and unsuitable for direct current (DC) cardioversion. Read More

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https://bmcpharmacoltoxicol.biomedcentral.com/articles/10.11
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http://dx.doi.org/10.1186/s40360-018-0279-1DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6311077PMC
December 2018
14 Reads

[The features and treatment of Xixia "May 17th" explosion accident].

Zhonghua Wei Zhong Bing Ji Jiu Yi Xue 2018 Dec;30(12):1196-1199

Department of Burns and Plastic Surgery, the Affiliated Nanshi Hospital of Henan University, Nanyang 473065, Henan, China. Corresponding author: Wang Shuo, Email:

Objective: To retrospectively analyze the injury characteristics of victims and treatment strategies in the explosion accident on the 17th May 2018 in Xixia county (Xixia "May 17th" explosion accident).

Methods: Completion the Level Three treatment on time, which was depended on the leading role played by the regional trauma centers was the main rescuing mode of the work in Xixia county, where the primary and secondary treatments were the key parts. The three-level treatment model includes: the local hospital acts as a level-one emergency medical institution, county hospitals function as secondary emergency medical institutions, and other higher medical institutions are the tertiary first aid medical institutions. Read More

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http://dx.doi.org/10.3760/cma.j.issn.2095-4352.2018.012.018DOI Listing
December 2018
13 Reads

Systematic review and meta-analysis of the protective effect of resveratrol on multiple organ injury induced by sepsis in animal models.

Biomed Rep 2019 Jan 14;10(1):55-62. Epub 2018 Nov 14.

Intensive Care Unit, The Second Hospital of Shanxi Medical University, Taiyuan, Shanxi 030001, P.R. China.

Sepsis may directly lead to multiple organ failure, which is among the leading causes of mortality in critically ill patients. According to data released by the Global Sepsis Alliance, the number of mortalities due to sepsis exceeded the combined number for prostate cancer, breast cancer and AIDS in 2012. To date, studies have reported that resveratrol has marked positive effects including anti-inflammatory, anti-oxidative and pro-microcirculatory functions in sepsis-induced organ injury, significantly improving the survival time and mortality of sepsis animals. Read More

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http://dx.doi.org/10.3892/br.2018.1169DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6299207PMC
January 2019
3 Reads

A dog's dinner: an interesting case presenting as gastroenteritis.

BMJ Case Rep 2018 Nov 28;11(1). Epub 2018 Nov 28.

Glasgow Royal Infirmary, Glasgow, UK.

We report a case of a 60-year-old Caucasian man with a history of alcohol excess who presented to the emergency department with a 72-hour history of abdominal pain, profuse diarrhoea and vomiting. He was admitted to the intensive care unit (ICU) 12 hours later in extremis with severe sepsis and multiorgan failure. Collateral history from the patient on admission to ICU identified that he had been bitten by a dog 3 days prior to his symptom onset. Read More

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http://dx.doi.org/10.1136/bcr-2018-226131DOI Listing
November 2018
1 Read

A Comparative Review of Neutrophil Extracellular Traps in Sepsis.

Front Vet Sci 2018 28;5:291. Epub 2018 Nov 28.

Department of Anatomy, Physiology and Cell Biology, School of Veterinary Medicine, University of California, Davis Davis, CA, United States.

Sepsis is the leading cause of critical illness and mortality in human beings and animals. Neutrophils are the primary effector cells of innate immunity during sepsis. Besides degranulation and phagocytosis, neutrophils also release neutrophil extracellular traps (NETs), composed of cell-free DNA, histones, and antimicrobial proteins. Read More

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http://dx.doi.org/10.3389/fvets.2018.00291DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6280561PMC
November 2018
3 Reads

Expression changes of CD177 and MPO as novel biomarkers in lung tissue of CLP model rats

Turk J Med Sci 2018 Dec 12;48(6):1321. Epub 2018 Dec 12.

National Institute of Scientific Research (INRS-ETE), University of Quebec, Quebec City, Canada

Background/aim: Sepsis is an unregulated systemic response to microbial invasion that can lead to multiple organ failure. This study aims at investigating the relationships among myeloperoxidase (MPO) and CD177 in major organ systems including whole blood, liver, and lung tissues in septic rats.

Materials And Methods: Sepsis was induced by cecal ligation and puncture (CLP) in female Wistar rats. Read More

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http://dx.doi.org/10.3906/sag-1806-223DOI Listing
December 2018

Parenteral Succinate Reduces Systemic ROS Production in Septic Rats, but It Does Not Reduce Creatinine Levels.

Oxid Med Cell Longev 2018 6;2018:1928945. Epub 2018 Nov 6.

Departamento de Bioquímica Humana. CONICET, INBIOMED, Universidad de Buenos Aires, Facultad de Medicina, Buenos Aires ZIP C1121ABE, Argentina.

In sepsis, reactive oxygen species (ROS) production is increased. This process takes place mainly within the electron transport chain. ROS production is part of the pathophysiology of multiple organ failure in sepsis. Read More

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http://dx.doi.org/10.1155/2018/1928945DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6247384PMC
January 2019
2 Reads

Therapeutic Plasma Exchange in Children With Thrombocytopenia-Associated Multiple Organ Failure: The Thrombocytopenia-Associated Multiple Organ Failure Network Prospective Experience.

Crit Care Med 2019 Mar;47(3):e173-e181

Department of Anesthesia and Critical Care Medicine, University of Pittsburgh School of Medicine, Children's Hospital of Pittsburgh, Pittsburgh, PA.

Objective: The objective was to compare the resolution of organ dysfunction, 28-day mortality, and biochemical markers in children with thrombocytopenia-associated multiple organ failure who received therapeutic plasma exchange versus no therapeutic plasma exchange.

Design: Observational longitudinal cohort study.

Setting: Nine U. Read More

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http://Insights.ovid.com/crossref?an=00003246-900000000-9606
Publisher Site
http://dx.doi.org/10.1097/CCM.0000000000003559DOI Listing
March 2019
23 Reads
6.312 Impact Factor