Search Our Scientific Publications & Authors

Shock 2021 Jun 10. Epub 2021 Jun 10.

Division of Infectious Diseases, Escola Paulista de Medicina, Universidade Federal de Sao Paulo - Sao Paulo - Brazil Laboratory of Medical Research - Faculty of Medicine of the University of São Paulo-USP, São Paulo, Brazil Chair of Pharmacology, Faculty of Science and Medicine, University of Fribourg, Fribourg, Switzerland.

Abstract: Sepsis' pathogenesis involves multiple mechanisms that lead to a dysregulation of the host's response. Significant efforts have been made in search of interventions that can reverse this situation and increase patient survival. Poly (ADP-polymerase) (PARP) is a constitutive nuclear and mitochondrial enzyme, which functions as a co-activator and co-repressor of gene transcription, thus regulating the production of inflammatory mediators. Read More

Coron Artery Dis 2021 Jun 10. Epub 2021 Jun 10.

Division of Nephrology, Beijing Anzhen Hospital, Capital Medical University, Beijing, P.R.China.

Background: Several studies have reported that prophylactic dialysis can reduce the mortality of non-dialysis-dependent chronic kidney disease (CKD) patients after cardiac surgery. However, the results of complications in these randomized controlled trials (RCTs) were not consistent. We aimed to perform a meta-analysis to systematically evaluate the effect of prophylactic dialysis in these non-dialysis-dependent CKD patients. Read More

Zhonghua Wei Zhong Bing Ji Jiu Yi Xue 2021 May;33(5):621-625

Department of Critical Care Medicine, the First People's Hospital Affiliated to Shanghai Jiao Tong University, Shanghai 201620, China.

Sepsis is caused by the imbalance of the host body's response to infection, which causes life-threatening organ dysfunction. Disorders of blood coagulation play a very important role in the development of sepsis. In sepsis, the body's coagulation system is activated, leading to hypercoagulability, while the anticoagulation mechanism is significantly inhibited, causing a large number of microthrombi to form, and disseminated intravascular coagulation (DIC) may occur. Read More

Zhonghua Wei Zhong Bing Ji Jiu Yi Xue 2021 May;33(5):513-516

Translational Medicine Research Center, Medical Innovation Research Division and the Fourth Medical Center of PLA General Hospital, Beijing 100048, China. Corresponding author: Yao Yongming, Email:

Sepsis is caused by various pathogens and toxic factors, which can lead to multiple organ dysfunction. The underlying mechanism of sepsis appears to be complex, involving epigenetic reprogramming, metabolic failure, immune dysfunction, neuroendocrine system disorders, coagulation abnormalities, tissue or organ failure, and many other scientific issues. With our deep understanding of the host reaction and development of sepsis, it is of great significance to explore predicative markers and therapeutic targets according to the atypical characteristics of sepsis, thereby contributing to the reduction of morbidity and mortality of sepsis. Read More

Mol Immunol 2021 Jun 1;136:65-72. Epub 2021 Jun 1.

Department of Biochemistry, All India Institute of Medical Sciences, New Delhi, India. Electronic address:

Trauma remains a major public health problem worldwide, marked as the fourth leading cause of death among all diseases. Trauma patients who survived at initial stages in the Emergency Department (ED), have significantly higher chances of mortality due to sepsis associated complications in the ICU at the later stage. There is paucity of literature regarding the role of circulating monocytes subsets and development of sepsis complications following trauma haemorrhagic shock (THS). Read More

Int J Mol Med 2021 Jul 3;48(1). Epub 2021 Jun 3.

Priority Medical Department, General Hospital of Central Theater Command, Wuhan, Hubei 430070, P.R. China.

Renal ischemia/reperfusion (I/R) injury often occurs during multiple organ failure and sepsis, and autophagy may serve a role in I/R injury. The aim of the present study was to explore the effect of microRNA (miR)‑30a‑5p on autophagy in renal I/R injury. miR‑30a‑5p and autophagy‑related protein expression levels in renal I/R injury mouse models and in hypoxia/re‑oxygenation HK‑2 cell models were determined using reverse transcription‑quantitative PCR or western blotting; apoptosis was analyzed using flow cytometry. Read More

Biomedicines 2021 May 17;9(5). Epub 2021 May 17.

Federal Research and Clinical Center of Intensive Care Medicine and Rehabilitology, 25-2 Petrovka Street, 107031 Moscow, Russia.

Mitochondrial dysfunction is currently considered one of the main causes of multiple organ failure in chronic inflammation and sepsis. The participation of microbial metabolites in disorders of bioenergetic processes in mitochondria has been revealed, but their influence on the mitochondrial membrane permeability has not yet been studied. We tested the influence of various groups of microbial metabolites, including indolic and phenolic acids, trimethylamine-N-oxide (TMAO) and acetyl phosphate (AcP), on the nonspecific permeability of mitochondrial membranes under conditions of acidosis, imbalance of calcium ions and excess free iron, which are inherent in sepsis. Read More

J Clin Med 2021 May 20;10(10). Epub 2021 May 20.

School of Medicine and Public Health, University of Newcastle, Callaghan, NSW 2308, Australia.

Deciding whether to delay non-lifesaving orthopaedic trauma surgery to prevent multiple organ failure (MOF) or sepsis is frequently disputed and largely based on expert opinion. We hypothesise that neutrophils and monocytes differentially express activation markers prior to patients developing these complications. Peripheral blood from 20 healthy controls and 162 patients requiring major orthopaedic intervention was collected perioperatively. Read More

Zhonghua Nei Ke Za Zhi 2021 Jun;60(6):533-538

Department of Critical Care Medicine, the First Affiliated Hospital of Anhui Medical University, Hefei 230000, China.

To study the predictive value of central venous-arterial CO difference (Pv-aCO)/arterial-central venous O difference (Ca-vO) ratio for progressive organ dysfunction in patients with septic shock after resuscitation. Septic shock patients receiving resuscitation in ICU were retrospectively enrolled from July 2018 to June 2019 at the First Affiliated Hospital Anhui Medical University. Hemodynamic and laboratory data were collected. Read More

Rom J Anaesth Intensive Care 2020 Dec 31;27(2):1-5. Epub 2020 Dec 31.

Department of Anesthesiology and Critical Care, General Intensive Care Unit, Soroka Medical Center, Ben-Gurion University of the Negev, Beer Sheva, Israel.

Background: Septic events complicated by hemodynamic instability can lead to decreased organ perfusion, multiple organ failure, and even death. Acute renal failure is a common complication of sepsis, affecting up to 50-70 % of cases, and it is routinely diagnosed by close monitoring of urine output. We postulated that analysis of the minute-to-minute changes in the urine flow rate (UFR) and also of the changes in its minute-to-minute variability might lead to earlier diagnosis of renal failure. Read More

Cureus 2021 Apr 24;13(4):e14668. Epub 2021 Apr 24.

Division of Infectious Diseases, University of Pittsburgh Medical Center Pinnacle, Harrisburg, USA.

Infection by , a Gram-negative rod found in the normal oral flora of canine and feline species and transmitted through bites or scratches, is a rare phenomenon. Infections most commonly occur in alcoholics and immunocompromised patients. In this report, we describe the case of a middle-aged male with a history of alcohol abuse who presented with septic shock and multisystem organ failure following a suspected dog bite. Read More

Zhonghua Wei Zhong Bing Ji Jiu Yi Xue 2021 Apr;33(4):433-437

Department of Anesthesiology, the First Affiliated Hospital, Zhejiang University School of Medicine, Hangzhou 310003, Zhejiang, China.

Objective: To illustrate a relatively complete knowledge system (e.g., research outputs, current hotspots, and future trends) in the sepsis field and to help scholars grasp the scientific research direction or clinical focus of treatment. Read More

Exp Gerontol 2021 May 26;151:111423. Epub 2021 May 26.

Department of Geriatrics, Shanghai Institute of Geriatrics, Huadong Hospital, Fudan University, Shanghai, PR China. Electronic address:

The coronavirus disease 2019 (COVID-19) is a new infectious respiratory disease, which has caused a pandemic that has become the world's leading public health emergency, threatening people of all ages worldwide, especially the elderly. Complications of COVID-19 are closely related to an upregulation of the inflammatory response revealed by the pro-inflammatory profile of plasma cytokines (to the point of causing a cytokine storm), which is also a contributing cause of the associated coagulation disorders with venous and arterial thromboembolisms, causing multiple organ dysfunction and failure. In severe fulminant cases of COVID-19, there is an activation of coagulation and consumption of clotting factors leading to a deadly disseminated intravascular coagulation (DIC). Read More

Methods Mol Biol 2021 ;2321:231-257

Department of Surgery, University of Vermont, Burlington, VT, USA.

Despite nearly 50 years of research there currently remains no mediator-directed therapy approved for the treatment of sepsis. The failure to effectively translate the copious mechanistic knowledge regarding systemic inflammation to effective therapies is a dramatic example of the translational dilemma. Dynamic computational modeling has been proposed as a vital means of integrating community-wide knowledge into an investigatory framework that allows the application of engineering-like principles to the problem of sepsis. Read More

Nutr Health 2021 May 26:2601060211018371. Epub 2021 May 26.

Department of Pharmacy Practice, Jerry H. Hodge School of Pharmacy, 15496Texas Tech University Health Sciences Center, USA.

Background: Sepsis and septic shock are severe medical conditions that can damage multiple organs with a higher risk of mortality. Recently, the combination of hydrocortisone, ascorbic acid and thiamine (HAT) was hypothesized to work synergistically to reverse septic shock and reduce mortality.

Aim: To ascertain the efficacy of HAT therapy and compare whether HAT therapy is more beneficial compared to the standard of care in sepsis and septic shock patients. Read More

Int J Gen Med 2021 12;14:1829-1841. Epub 2021 May 12.

Department of Emergency Medicine, The Second Xiangya Hospital, Central South University, Changsha, Hunan, People's Republic of China.

Background: Sepsis is a life-threatening multiple-organ dysfunction caused by dysregulation of host response to severe infection. Liver failure is a validated independent predictor of mortality. Accurate and rapid assessment of liver function is critical in patients with sepsis. Read More

Eur J Case Rep Intern Med 2021 15;8(4):002434. Epub 2021 Apr 15.

Department of Internal Medicine, University Hospital of Mohammed VI, Marrakesh, Morocco.

Necrotizing fasciitis is a serious soft tissue infection that causes necrosis of the subcutaneous tissues and the muscle fascia. It is associated with a high mortality rate of around 25%. Necrotizing fasciitis of the breast is a rare entity. Read More

Acute Med Surg 2021 Jan-Dec;8(1):e654. Epub 2021 May 1.

Internal Medicine III Wakayama Medical University Wakayama Japan.

Aim: The emergency department requires simple and useful clinical indicators to identify bacteremia. This retrospective study explored the Systemic Inflammatory Response Syndrome (SIRS) and quick Sequential Organ Failure Assessment (qSOFA) scores for predicting bacteremia.

Methods: Between April and September 2017, we assessed blood cultures of 307 patients in our emergency department. Read More

Int J Emerg Med 2021 May 7;14(1):29. Epub 2021 May 7.

Department of Emergency Medicine, Teaching Hospital Mór Kaposi, Tallián Gyula Street 20-32, Kaposvár, 7400, Hungary.

Background: Cardiac tumors are very uncommon compared to other cardiac diseases. Their clinical symptoms can vary from absent to non-specific. The most common symptoms are arrhythmias, blood flow obstruction due to valvular dysfunction, shortness of breath, systemic embolization, and accumulation of pericardial fluid. Read More

Stem Cell Res Ther 2021 May 6;12(1):269. Epub 2021 May 6.

Chongqing Key Laboratory of Pediatrics, Chongqing, People's Republic of China.

Background: Sepsis is a systemic inflammatory response to a local severe infection that may lead to multiple organ failure and death. Previous studies have shown that 40-50% of patients with sepsis have diverse myocardial injuries and 70 to 90% mortality rates compared to 20% mortality in patients with sepsis without myocardial injury. Therefore, uncovering the mechanism of sepsis-induced myocardial injury and finding a target-based treatment are immensely important. Read More

Crit Care 2021 05 5;25(1):165. Epub 2021 May 5.

Perioperative Medicine and Intensive Care, Karolinska University Hospital, Solna, 171 76, Stockholm, Sweden.

Background: Understanding temporal patterns of organ dysfunction (OD) may aid early recognition of complications after trauma and assist timing and modality of treatment strategies. Our aim was to analyse and characterise temporal patterns of OD in intensive care unit-admitted trauma patients.

Methods: We used group-based trajectory modelling to identify temporal trajectories of OD after trauma. Read More

Ther Clin Risk Manag 2021 22;17:365-369. Epub 2021 Apr 22.

Department of Dental Anesthesiology, Ohu University, School of Dentistry, Koriyama City, Fukushima Prefecture, Japan.

In general dental conditions such as dental caries and periodontal disease, a combination of adverse conditions can cause potentially life-threatening periodontal abscess. We treated a patient in whom an oral infection developed into septic shock, resulting in patient death. A 78-year-old woman experienced spontaneous pain around a moving tooth. Read More

J Pediatr Intensive Care 2021 Jun 30;10(2):110-117. Epub 2020 Jul 30.

Department of Pediatric Intensive Care, St Johns Medical College and Hospital, Bengaluru, Karnataka, India.

Sequential organ failure assessment (SOFA) score is used as a predictor of outcome of sepsis in the pediatric intensive care unit. The aim of the study is to determine the application of SOFA scores as a predictor of outcome in children admitted to the pediatric intensive care unit with a diagnosis of sepsis. The design involved is prospective observational study. Read More

Eur Rev Med Pharmacol Sci 2021 04;25(7):3136-3144

Department of Anaesthesiology and Critical Care, University of Pennsylvania, Philadelphia, PA, USA.

Objective: Disruption of intracellular Ca2+ homeostasis via excessive and pathological Ca2+ release from the endoplasmic reticulum (ER) and/or sarcoplasmic reticulum (SR) through ryanodine receptor (RyRs) Ca2+ channels play a critical role in the pathology of systemic inflammatory response syndrome (SIRS) and associated multiple organ dysfunction syndrome (MODS) in sepsis or septic shock. Dantrolene, a potent inhibitor of RyRs, is expected to ameliorate SIRS and MODS and decrease mortality in sepsis or septic shock patients. This review summarized the potential mechanisms of therapeutic effects of dantrolene in sepsis or septic shock at molecular, cell, and organ levels and provided suggestions and strategies for future clinical studies. Read More

Sci Rep 2021 Apr 19;11(1):8471. Epub 2021 Apr 19.

Division of Neonatology and Pediatric Hematology/Oncology, Department of Pediatrics, Chang Gung Memorial Hospital, No.707, Gongye Rd., Sansheng, Mailiao Township, Yunlin, Taiwan, ROC.

Despite wide application of high frequency oscillatory ventilation (HFOV) in neonates with respiratory distress, little has been reported about its rescue use in preterm infants. We aimed to evaluate the therapeutic effects of HFOV in preterm neonates with refractory respiratory failure and investigate the independent risk factors of in-hospital mortality. We retrospectively analyzed data collected prospectively (January 2011-December 2018) in four neonatal intensive care units of two tertiary-level medical centers in Taiwan. Read More

World J Clin Cases 2021 Apr;9(10):2160-2169

Instituto Multidisciplinar em Saúde, Universidade Federal da Bahia, Vitória da Conquista 45029-094, Bahia, Brazil.

Intra-abdominal infections can be classified into uncomplicated or complicated (peritonitis). Peritonitis is divided into primary, secondary, and tertiary. Tertiary peritonitis is the less common but the most severe among peritonitis stratifications, being defined as a recurrent intra-abdominal infection that occurs 48 h after a well-succeeded control of a secondary peritonitis. Read More

Wilderness Environ Med 2021 Jun;32(2):226-229

Saint Louis University School of Medicine, Division of Emergency Medicine, St. Louis, MO.

A previously healthy 51-y-old male presented to his local emergency department with subjective fevers, myalgias, dyspnea, and generalized weakness that had been progressive for several weeks. He was initially diagnosed with bilateral pneumonia, septic shock, and rhabdomyolysis requiring transfer to a tertiary care facility. He was treated for sepsis with broad-spectrum antibiotics, steroids, and a fluid bolus before transfer. Read More

Int J Crit Illn Inj Sci 2020 Oct-Dec;10(4):216-219. Epub 2020 Dec 29.

Medical Intensive Care Unit, University Clinical Center of Republic of Srpska, Banja Luka, Bosnia and Herzegovina.

Acute respiratory distress syndrome is an acute inflammatory lung process, which leads to protein-rich nonhydrostatic pulmonary edema, refractory hypoxemia, and lung "stiffness". There are a number of therapies that are currently being investigated in the treatment of sepsis; one of the most promising treatment options at this moment is cytokine removal by hemoperfusion (CytoSorb). We present the case of a 29-year-old male patient who was admitted to the Medical Intensive Care Unit in a state of multiple organ dysfunction and massive bilateral pneumonia caused by influenza type A. Read More

BMC Pregnancy Childbirth 2021 Apr 12;21(1):293. Epub 2021 Apr 12.

Department of Obstetrics and Gynecology, Mackay Memorial Hospital, No. 92, Section 2, Zhong-Shan North Road, 10449, Taipei, Taiwan.

Background: Acute fatty liver of pregnancy (AFLP) and hemolysis, elevated liver enzymes and low platelets (HELLP) syndrome are two uncommon disorders that mimic each other clinically, but are distinct pathophysiologically. This study aimed to compare maternal and neonatal outcomes between AFLP and HELLP syndrome.

Methods: This retrospective cohort study was performed at a tertiary referral center in Taiwan between June 2004 and April 2020. Read More

Front Med (Lausanne) 2021 25;8:582896. Epub 2021 Mar 25.

Intensive Care Unit, IRCCS Orthopedic Institute Galeazzi, Milan, Italy.

Italy was one of the worst affected European countries during the severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) pandemic. More than 50% of Italian cases occurred in the northern region of Lombardy, where the saturation of health services between March and April 2020 forced hospitals to allocate patients according to available resources. Eighteen severe coronavirus disease 2019 (COVID-19) patients were admitted to our hospital needing intensive support. Read More