1,248,342 results match your criteria Multiple Sclerosis Spine
Cell Microbiol 2018 Dec 14:e12993. Epub 2018 Dec 14.
Institute for Microbiology and Hygiene, Medical Center - University of Freiburg, Faculty of Medicine, University of Freiburg, Germany.
The obligate intracellular bacterium Chlamydia trachomatis replicates in a cytosolic vacuole in human epithelial cells. Infection of human cells with C. trachomatis causes substantial changes to many host cell signalling pathways but the molecular basis of such influence is not well understood. Read More
J Public Health Dent 2018 Dec 14. Epub 2018 Dec 14.
Section of Population Oral Health, Columbia University College of Dental Medicine, New York, NY, USA.
Objectives: To identify and characterize US early childhood caries (ECC) programs.
Methods: A 39 question online survey was fielded to 245 ECC programs identified from the literature and peer programs. The 101 respondents (41 percent response rate) reported their program's geographic reach, type, areas of focus, target populations, approaches, affiliations, providers, goals, costs, and funding. Read More
J Gastroenterol Hepatol 2018 Dec 14. Epub 2018 Dec 14.
Department of Gastroenterology and Hepatology, Erasmus MC University Medical Center, Rotterdam, The Netherlands.
Background And Aim: Notwithstanding multiple recommendations in guidelines, percutaneous endoscopic gastrostomy (PEG)-tube placement is still performed in patients with dementia. In this study we aim to investigate survival in patients with and without dementia after (PEG)-tube placement.
Methods: We conducted a retrospective multicenter study in four different hospitals in The Netherlands. Read More
Trans R Soc Trop Med Hyg 2018 Dec 14. Epub 2018 Dec 14.
Department of Parasitology, Faculty of Medicine, University of Malaya,Kuala Lumpur, Malaysia.
Background: Parasitic infections constitute a major public health problem worldwide, particularly among underprivileged communities in developing countries including Nigeria. The present study aimed to determine the epidemiology of polyparasitism (multiple parasitic infections) among rural communities in Kano State, North Central Nigeria.
Methods: A total of 551 individuals were screened for the presence of intestinal, urogenital and blood parasites by using different diagnostic techniques. Read More
Ann Work Expo Health 2018 Dec 14. Epub 2018 Dec 14.
Dalla Lana School of Public Health, University of Toronto, Toronto, Ontario, Canada.
Introduction: Interpretation of exposure measurements has evolved into a framework based on the lognormal distribution. Most available practical tools are based on traditional frequentist statistical procedures that do not satisfactorily account for censored data and are not amenable to simple probabilistic risk statements. Bayesian methods offer promising solutions to these challenges. Read More
Transl Behav Med 2018 Dec 13. Epub 2018 Dec 13.
Duluth Medical Research Institute, University of Minnesota, Duluth, MN, USA.
Early life adversities (ELAs) are shown as significant risk factors for chronic health conditions (CHCs). ELAs include multiple types of abuse such as the social abuse (peer, community, and collective violence). The purpose is to describe the relationship between childhood social abuse and chronic conditions in adulthood among a sample of adults in Tunisia and to investigate the role of obesity and tobacco use as mediators of this association. Read More
Nucleic Acids Res 2018 Dec 15. Epub 2018 Dec 15.
Université de Rennes 1, Inserm, BRM (Bacterial Regulatory RNAs and Medicine) UMR_S 1230, 35000 Rennes, France.
Toxin-antitoxin (TA) systems are ubiquitous among bacteria, frequently expressed in multiple copies, and important for functions such as antibiotic resistance and persistence. Type I TA systems are composed of a stable toxic peptide whose expression is repressed by an unstable RNA antitoxin. Here, we investigated the functionalities, regulation, and possible cross-talk between three core genome copies of the pathogenicity island-encoded 'sprG1/sprF1' type I TA system in the human pathogen Staphylococcus aureus. Read More
PLoS One 2018 14;13(12):e0207139. Epub 2018 Dec 14.
College of Pharmacy, Nanchang University, Nanchang, Jiangxi, P.R. China.
Tumor suppressor genes (TSGs), including Ten-eleven translocation 1 (TET1), are hypermethylated in hepatocellular carcinoma (HCC). TET1 catalytic domain (TET1-CD) induces genome-wide DNA demethylation to activate TSGs, but so far, anticancer effects of TET1-CD are unclear. Here we showed that after HCC cells were transiently transfected with TET1-CD, the methylation levels of TSGs, namely APC, p16, RASSF1A, SOCS1 and TET1, were distinctly reduced, and their mRNA levels were significantly increased and HCC cells proliferation, migration and invasion were suppressed, but the methylation and mRNA levels of oncogenes, namely C-myc, Bmi1, EMS1, Kpna2 and c-fos, were not significantly change. Read More
Nutrition 2018 Oct 5;60:100-105. Epub 2018 Oct 5.
Department of Surgery, Oregon Health Sciences University, Portland, Oregon, USA.
Strategies for providing optimal nutritional therapy have evolved over time, with the emphasis on specific directives (such as route, use of immunonutrition, high protein, organ-specific formulas, etc.), achieving variable degrees of success for improving outcomes in the intensive care unit. As the largest immune organ in the body comprising the largest interface between the host and the external environment, the gut can have an amplifying effect on a pattern of dysbiosis, immune dysregulation, and multiple organ failure seen in the critically ill patient. Read More
Chemosphere 2018 Nov 29;219:335-344. Epub 2018 Nov 29.
Water Science and Management Program, New Mexico State University, MSC 3Q P.O. Box 30003, Las Cruces, NM 88003, USA; Plant & Environmental Science, New Mexico State University, MSC 3Q P.O. Box 30003, Las Cruces, NM 88003, USA. Electronic address:
Enhanced reactivity of aqueous ozone (O) with hydroxypropyl-β-cyclodextrin (HPβCD) and its impact on relative reactivity of O with contaminants were evaluated herein. Oxidation kinetics of 1,4-dioxane, trichloroethylene (TCE), and 1,1,1-trichloroethane (TCA) using O in single and multiple contaminant systems, with and without HPβCD, were quantified. 1,4-Dioxane decay rate constants for O in the presence of HPβCD increased compared to those without HPβCD. Read More
Curr Opin Chem Biol 2018 Dec 11;49:97-104. Epub 2018 Dec 11.
Heterogeneous biocatalysis laboratory, Instituto de Síntesis Química y Catálisis Homogénea (ISQCH-CSIC), University of Zaragoza, C/ Pedro Cerbuna 12, 50009, Zaragoza, Spain; ARAID, Aragon I+D foundation, Zaragoza, Spain. Electronic address:
During the past decades, biocatalysis has made important contributions to chemical manufacturing by using both whole-cell and cell-free biotransformation reactions. More recently, multi-enzyme systems that can run step-wise reactions in one-pot with high selectivity are increasingly being developed. The use of multiple isolated enzymes to perform a series of reactions offers operational and process advantages over the use of living or resting cells, but such cell free processes need to be optimized to meet industrial productivity and titer requirements. Read More
Eur J Cancer 2018 Dec 11;107:68-78. Epub 2018 Dec 11.
Department of Genetics, Cell Biology and Anatomy, College of Medicine, USA; Cancer Centre and Institute of Translational Medicine, Faculty of Health Sciences, University of Macau, Taipa, Macau, SAR, China. Electronic address:
Purpose: The presence of pathogenic germline mutation in BRCA1 gene is considered as the most penetrant genetic predisposition for breast cancer. However, a portion of BRCA1 mutation carriers never develops breast cancer throughout their lifetime. This phenomenon is called incomplete penetrance. Read More
Mult Scler Relat Disord 2018 Nov 28;28:26-30. Epub 2018 Nov 28.
Division of Genetics, Birth Defects and Metabolism, Department of Pediatrics, Ann and Robert H. Lurie Children's Hospital of Chicago and Northwestern Feinberg School of Medicine Chicago, IL 60611, USA. Electronic address:
Background: Multiple sclerosis is a disorder of the central and peripheral nervous system of young and old adults that is characterized by muscle, coordination and vision abnormalities. Multiple sclerosis is likely due to numerous causes.
Methods: Recently, adolescents and adults with ophthalmological and or neurological findings have been diagnosed with biotinidase deficiency. Read More
Biomed Pharmacother 2018 Dec 11;111:1-5. Epub 2018 Dec 11.
Department of Cardiology, Rui Jin Hospital, School of Medicine, Shanghai Jiao Tong University, Shanghai, 20025, PR China. Electronic address:
The interleukin-1 (IL-1) signaling pathway plays a vital role in multiple mechanisms associated with myocardial ischemia-reperfusion (I/R) injury, including inflammation and apoptosis. An IL-1 receptor antagonist (IL-1Ra) can block IL-1 by competitive binding to the IL-1 receptor type I (IL-1RI) and thus may provide a cardioprotective effect. In the present investigation, we determined whether exogenous administration of recombinant human IL-1Ra (rhIL-1Ra) provides a protective role against myocardial I/R injury. Read More
Colloids Surf B Biointerfaces 2018 Dec 4;175:281-290. Epub 2018 Dec 4.
Department of Materials Science and Engineering, Indian Institute of Technology, Delhi, 110016, India. Electronic address:
Biodegradable polymer based 'controlled release packaging' technology has ability to release packaging actives in controlled manner to prolong the food shelf-life. Currently available systems are not sufficiently capable of releasing multiple actives in sustainable fashion. Hence, the purpose of this study was to develop dual actives (antioxidant and antibacterial) loaded multilayered microparticles in one step and to release them at rates suitable for long-term inhibition of bacterial growth as well as lipid oxidation in food. Read More
J Inorg Biochem 2018 Dec 5;192:7-16. Epub 2018 Dec 5.
Department of Chemistry, Graduate School of Science and Engineering, Shimane University, 1060 Nishikawatsu, Matsue 690-8504, Japan. Electronic address:
The cationic Ga(III) and Zn(II) phthalocyanines carrying N-methyl-pyridinium groups at eight peripheral β-positionshave been synthesized. These complexes are highly soluble in dimethyl sulfoxide (DMSO) and moderately soluble in water and phosphate buffered saline (PBS); both Ga(III)Cl and Zn(II) complexes have shown no aggregation in water up to 1.2 × 10 and 1. Read More
Mol Immunol 2018 Dec 11;105:198-204. Epub 2018 Dec 11.
Central Diagnostic Laboratory, Maastricht University Medical Center, Maastricht, the Netherlands. Electronic address:
Different laboratory approaches have been exploited to analyze an effect of vitamin D supplements on T cell cytokine profiles in multiple sclerosis, with poorly reproducible results. We assessed the correlation between intra-cellular flowcytometry analysis of CD4 T cell-enriched CD3CD8 lymphocytes after PMA/ionomycin stimulation directly ex-vivo or after 72 h pre-stimulation with anti-CD3, and cytokine levels excreted in culture supernatants. Pre-stimulation with anti-CD3 resulted in higher proportions of cells positive for IFN-γ, IL-17 A, IL-4, IL-10 and GM-CSF (all P < 0. Read More
Parasitol Int 2018 Dec 11. Epub 2018 Dec 11.
Department of Parasitology, Graduate School of Medical Sciences, Kanazawa University, Kanazawa 920-8640, Japan. Electronic address:
Retortamonas spp. has been reported as an intestinal parasite among various host organisms, including humans; however, its intra-genus molecular diversity has not yet been elucidated. Haplotypes of the 18S small subunit ribosomal RNA locus (1836-1899 bp) of Retortamonas spp. Read More
Insect Biochem Mol Biol 2018 Dec 11. Epub 2018 Dec 11.
College of Plant Protection, Nanjing Agricultural University, Nanjing, China. Electronic address:
Glutamate-gated chloride channels (GluCls) are found only in invertebrates and mediate fast inhibitory neurotransmission. The structural and functional diversity of GluCls are produced through assembly of multiple subunits and via posttranscriptional alternations. Alternative splicing is the most common way to achieve this in insect GluCls and splicing occurs primarily at exons 3 and 9. Read More
Mol Phylogenet Evol 2018 Dec 11. Epub 2018 Dec 11.
Department of Botany and Zoology, Masaryk University, Kotlářská 2, CZ-61137, Brno, Czechia. Electronic address:
Naive use of molecular data may lead to ambiguous conclusions, especially within the context of "cryptic" species. Here, we integrated molecular and morphometric data to evaluate phylogenetic relationships in the widespread terrestrial micro-snail genus, Euconulus. We analyzed mitochondrial (16S + COII) and nuclear (ITS1 + ITS2) sequence across 94 populations from Europe, Asia and North America within the nominate species E. Read More
Mol Phylogenet Evol 2018 Dec 11. Epub 2018 Dec 11.
Department of Zoology and Animal Cell Biology, Faculty of Pharmacy, University of the Basque Country, EHU/UPV, Paseo de la Universidad 7, 01006 Vitoria-Gasteiz, Araba, Spain; Biodiversity Research Group CIEA Lucio Lascaray, Avda. Miguel de Unamuno 3, 01006, Araba, Spain. Electronic address:
To accurately delimit species the use of multiple character types is essential as all speciation processes are not equally reflected in different data (e.g. morphological, molecular or ecological characters). Read More
Semin Cancer Biol 2018 Dec 11. Epub 2018 Dec 11.
Molecular Oncology group, Biodonostia Research Institute, Paseo Doctor Begiristain, s/n San Sebastián, 20014, Spain; Radcliffe Department of Medicine, University of Oxford, John Radcliffe Hospital, Oxford, OX3 9DU, United Kingdom; IKERBASQUE, Basque Foundation for Science, María Díaz Haroko Kalea, 3, 48013, Bilbao, Spain. Electronic address:
Circular RNAs (circRNAs) are a novel class of regulatory RNAs that despite being relatively abundant have only recently begun to be explored. There are many thousands of genes that appear capable of producing circRNAs, however the function of all but a handful remain to be determined. What is emerging about these highly conserved molecules is that they play important roles in biology and cancer biology in particular. Read More
Behav Brain Res 2018 Dec 11. Epub 2018 Dec 11.
Oregon Health & Science University, Portland, OR, United States; VA Portland Health Care System, Portland, OR. United States. Electronic address:
Sensory gating, the ability to suppress sensory information of irrelevant stimuli, is affected in several neuropsychiatric diseases, notably schizophrenia and autism. It is currently unclear how these deficits interact with other hallmark symptoms of these disorders, such as social withdrawal and difficulty with interpersonal relationships. The highly affiliative prairie vole (Microtus ochrogaster) may be an ideal model organism to study the neurobiology underlying social behavior. Read More
J Control Release 2018 Dec 11. Epub 2018 Dec 11.
College of Pharmacy and Research Institute of Pharmaceutical Sciences, Seoul National University, Seoul 08826, Republic of Korea. Electronic address:
Noncovalent forces are of considerable importance in the formation of self-assembled drug-delivery systems. In addition to non-destructively linking the delivery vehicle and guest drug, they provide multiple advantages, including protecting the structure of the drug, maintaining its functional effects, and facilitating its release. In particular, π-π stacking interactions have potential application in a comprehensive range of biomedical and biotechnological fields. Read More
Clin Chim Acta 2018 Dec 11. Epub 2018 Dec 11.
Department of Clinical-Laboratory and Experimental-Research Medicine, Toho University Sakura Medical Center, 564-1 Shimoshizu, Sakura 285-8741, Japan. Electronic address:
Background: The levels of plasma sLR11, released from intimal SMCs, are positively associated with intima-media thickness (IMT) in asymptomatic subjects. We have evaluated the yet unknown pathological significance of sLR11 for plaque conditions in patients with carotid artery stenosis.
Methods: The presence of LR11 in carotid plaques was investigated using autopsy specimens. Read More
Sci Total Environ 2018 Dec 5;657:509-516. Epub 2018 Dec 5.
China National Center for Food Safety Risk Assessment, Beijing 100022, China. Electronic address:
Hand, foot and mouth disease (HFMD) remains an increasing public health concern. The spatiotemporal variation of HFMD can be represented from multiple-perspectives, and it may be driven by different dominant factors. In this study, the HFMD cases in children under the age of five years in each county in Henan province, China, from 2009 to 2013 were assessed to explore the integrative spatiotemporal patterns of HFMD and investigate their driving factors. Read More
Sci Total Environ 2018 Dec 4;657:446-456. Epub 2018 Dec 4.
State Key Laboratory of Lake Science and Environment, Nanjing Institute of Geography and Limnology, Chinese Academy of Sciences, Nanjing 210008, China.
There is a requirement for simultaneous measurements of diverse analytes to reveal their biogeochemical couplings in the environment. In this study, we first realized simultaneous measurements of three types of analytes, including sulfide [S(-II)], metallic cations, and oxyanions by diffusive gradients in thin films (DGT) using a new mixed ZrO-CA binding gel. The ZrO-CA gel exhibited faster absorption rates for oxyanions than previously reported ZrO-Chelex gel, and faster absorption rates for cations when the gel was saturated with S(-II). Read More
Sci Total Environ 2018 Dec 4;657:379-390. Epub 2018 Dec 4.
Department of Agriculture, Food and Environment, University of Pisa, Via del Borghetto 80, Pisa 56124, Italy; CIRSEC, Centre for Climatic Change Impact, University of Pisa, Via del Borghetto 80, Pisa 56124, Italy.
There is a lack of knowledge about the possibility that plants facing abiotic stressors, such as drought, have an altered perception of a pulse of O and incur in alterations of their signalling network. This poses some concerns as to whether defensive strategy to cope episodic O peaks in healthy plants may fail under stress. In this study, a set of saplings of two Mediterranean deciduous species, Quercus cerris and Q. Read More
Sci Total Environ 2018 Nov 30;657:340-350. Epub 2018 Nov 30.
Institute for Sustainable Plant Protection, National Research Council, Via Madonna del Piano 10, Sesto Fiorentino, Florence 50019, Italy.
We tested the independent and interactive effects of nitrogen (N; 0 and 80 kg ha), phosphorus (P; 0, 40 and 80 kg ha), and ozone (O) application/exposure [ambient concentration (AA), 1.5 × AA and 2.0 × AA] for five consecutive months on biochemical traits of the O-sensitive Oxford poplar clone. Read More
Microb Pathog 2018 Dec 11. Epub 2018 Dec 11.
Key Laboratory of Ministry of Education for Conservation and Utilization of Special Biological Resources in the Western China, Yinchuan, 750021, Ningxia, China; College of Life Science, Ningxia University, Yinchuan, 750021, Ningxia, China. Electronic address:
Mycobacterium tuberculosis (Mtb)-induced autophagy of alveolar macrophages has been confirmed to play a central role in the pathogenesis of tuberculosis. Growing evidence indicates that excessive or uncontrolled autophagic activity, which results in type II programmed cell death, can be regulated by many factors, including Wnt/β-catenin signalling. Wnt/β-catenin signalling has been demonstrated to be involved in multiple diseases through the regulation of autophagy; however, its exact role in regulating autophagy induced by Mtb remains unclear. Read More
Travel Med Infect Dis 2018 Dec 11. Epub 2018 Dec 11.
Aix Marseille Univ, Institut de Recherche pour le Développement (IRD), Assistance Publique-Hôpitaux de Marseille (AP-HM), Service de Santé des Armées (SSA), Microbes Vecteurs Infections Tropicales et Méditerranéennes (VITROME), Institut Hospitalo-Universitaire-Méditerranée Infection (IHU-Méditerranée Infection), Marseille, France.
Background: The Middle East Respiratory Syndrome Coronavirus (MERS-CoV) emerged in 2012 and attracted an international attention as the virus caused multiple healthcare associated outbreaks. There are reports of the role of asymptomatic individuals play in the transmission of MERS-CoV, however, the exact role is now known.
Method: The MEDLINE/PubMed and Scopus databases were searched for relevant papers published till August 2018 describing asymptomatic MERS-CoV infection. Read More
Eur J Med Genet 2018 Dec 11. Epub 2018 Dec 11.
King's College London, Florence Nightingale Faculty of Nursing, Midwifery and Palliative Care, London, United Kingdom; Faculty of Health and Wellbeing, Sheffield Hallam University, Sheffield, United Kingdom.
Within the field of breast cancer care, women concerned about their family history are offered genetic testing and subsequent treatment options based on several factors which include but are not limited to personal and family cancer disease histories and clinical guidelines. Discussions around decision-making in genetics in Black and Minority Ethnic (BME) groups are rarely documented in literature, and information regarding interactions with genetics services is usually discussed and linked to lack of scientific knowledge. As such, counselling sessions based only on scientific and medical information miss out the many reasons participants consider in making health decisions, information which can be used to encourage BME women to engage in cancer genetics services. Read More
Int J Biol Macromol 2018 Dec 11. Epub 2018 Dec 11.
Faculty of Food Science and Nutrition, School of Health Sciences, University of Iceland. University of Iceland, Sæmundargata 2, 101 Reykjavik, Iceland. Electronic address:
Atlantic cod trypsin ZT is biochemically characterized for the first time in this report in comparison to a group I trypsin (cod trypsin I). To our knowledge, trypsin ZT is the first thoroughly characterized group III trypsin. A more detailed understanding of trypsin ZT biochemistry may give insight into its physiological role as well as its potential use within the biotechnology sector. Read More
Micron 2018 Dec 7;118:1-8. Epub 2018 Dec 7.
Department of Materials Science and Engineering, University of Florida, Gainesville, FL 32611, United States. Electronic address:
A wide variety of specimen preparation techniques are available for ensuring that specimen surface finish has the acceptable quality for electron backscatter diffraction (EBSD) analysis. These techniques include but are not limited to vibratory polishing, broad, and focused ion beam milling. They have been widely implemented in the field of nuclear materials science with a varying degree of success. Read More
Int J Radiat Oncol Biol Phys 2018 Dec 11. Epub 2018 Dec 11.
Department of Radiation Oncology, Medical College of Wisconsin, Milwaukee, WI.
Purpose/objective(s): To develop an automatic and accurate atlas based technique for synthetic CT (sCT) generation to be used for online adaptive replanning during MRI guided radiation therapy (RT).
Materials/methods: The proposed method utilizes deformable image registration (DIR) of daily MRI and reference CT with additional corrections to maintain bone rigidity and also transfer of random air regions by thresholding. The DIR is performed with constraints on the bony structures using a special algorithm of ADMIRE (Elekta). Read More
Immunol Lett 2018 Dec 11. Epub 2018 Dec 11.
Department of Biology and Guangdong Provincial Key Laboratory of Marine Biotechnology, Shantou University, Shantou, 515063, China. Electronic address:
Tolls and Toll-like receptors (TLRs), as innate immune-recognition receptors that recognize molecular patterns associated with microbial pathogens, play a critical role in antimicrobial immune responses. Here, we report on single nucleotide polymorphisms (SNPs) of Litopenaeus vannamei Toll3 (LvToll3). Multiple sequence alignment of the L. Read More
Prog Biophys Mol Biol 2018 Dec 11. Epub 2018 Dec 11.
School of Chemistry, University of Hyderabad, Hyderabad, Telangana, 500046, India. Electronic address:
Tuberculosis is one of the leading causes of death from bacterial infections. The multi-drugresistant strain has warranted the development of new drug molecules which can inhibit the growth of Mycobacterium tuberculosis. Most of the known drugs inhibit the enzymes in the cell wall biosynthesis. Read More
Pediatr Dev Pathol 2018 Dec 14:1093526618817655. Epub 2018 Dec 14.
1 Department of Pathology and Laboratory Medicine, University of Calgary, Calgary, Canada.
Alpha thalassemia major is a hemoglobinopathy caused by the inactivation or deletion of all 4 α-globin alleles. We describe a case of α-thalassemia major with atypical ultrasound and neuropathological findings. The mother had her first prenatal visit at 27 4/7 gestational weeks. Read More
J Gastroenterol Hepatol 2018 Dec 14. Epub 2018 Dec 14.
Department of Medicine, College of Medicine, Kaohsiung Medical University, Kaohsiung, Taiwan.
Background: Asian populations have relatively lower prevalence of gastroesophageal reflux disease and tend to exhibit symptoms of prolonged gastric retention. However, it remains unknown if slower gastric empting influences its features in Asian countries.
Aim: We prospectively assessed the potential implications of slower gastric emptying in an Asian-Pacific cohort of gastroesophageal reflux disease by a hospital-based survey. Read More
Invest Ophthalmol Vis Sci 2018 Dec;59(15):5862-5867
Department of Clinical Epidemiology and Biostatistics, Asan Medical Center, University of Ulsan College of Medicine, Seoul, Korea.
Purpose: To investigate whether the relationship between circumpapillary vascular density (cpVD) and visual field (VF) mean sensitivity (MS) differs between primary open-angle (POAG) and angle-closure glaucoma (PACG).
Methods: The cpVD and retinal nerve fiber layer thickness (RNFLT) were obtained using optical coherence tomography angiography (OCTA, AngioVue/RTVue-XR) in 146 eyes from 146 subjects (age- and VF mean deviation-matched 86 POAG and 60 PACG). Global and regional relationships (superotemporal [ST], superonasal [SN], nasoupper [NU], nasolower [NL], inferonasal [IN], inferotemoporal [IT], temporolower [TL], and temporoupper [TU] sectors) were estimated between cpVD and VF MS using multiple linear regression models controlling for the confounding variables in two disease categories. Read More
PLoS One 2018 14;13(12):e0209095. Epub 2018 Dec 14.
Division of Neonatology and Pediatric Molecular and Personalized Medicine Program, Department of Pediatrics, University of Rochester, Rochester, New York, United States of America.
Basement membrane (BM) is an essential part of the extracellular matrix (ECM) that plays a crucial role in mechanical support and signaling to epithelial cells during lung development, homeostasis and repair. Abnormal composition and remodeling of the lung ECM have been associated with developmental abnormalities observed in multiple pediatric and adult respiratory diseases. Collagen VI (COL6) is a well-studied muscle BM component, but its role in the lung and its effect on pulmonary epithelium is largely undetermined. Read More
PLoS Negl Trop Dis 2018 Dec 14;12(12):e0006941. Epub 2018 Dec 14.
Swiss Tropical and Public Health Institute, Basel, Switzerland.
Background: Intervention guidelines against Schistosoma mansoni are based on the Kato-Katz technique. However, Kato-Katz thick smears show low sensitivity, especially for light-intensity infections. The point-of-care circulating cathodic antigen (POC-CCA) is a promising rapid diagnostic test detecting antigen output of living worms in urine and results are reported as trace, 1+, 2+, and 3+. Read More
PLoS One 2018 14;13(12):e0209417. Epub 2018 Dec 14.
Department of Veterinary Integrative Biosciences, Texas A&M University, College Station, Texas, United States of America.
Uterine gland development, also known as adenogenesis, is a key uterine morphogenic process indispensable for normal uterine function and fertility. Our earlier studies have reported that overactivation of TGFB receptor 1 (TGFBR1) in the mouse uterus using progesterone receptor (Pgr)-Cre recombinase causes female infertility, defective decidualization, and reduced uterine gland formation, a developmental milestone of postnatal uterus. To understand mechanisms that underpin the disrupted uterine gland formation in mice with sustained activation of TGFBR1, we raised the question of whether early postnatal adenogenesis was compromised in these mice. Read More
PLoS One 2018 14;13(12):e0209375. Epub 2018 Dec 14.
Department of Public Health, Erasmus Medical Center, Rotterdam, The Netherlands.
This study, conducted in the Netherlands, evaluated the association between ethnic background and children's TV viewing time at multiple time points and its trajectory. We analyzed 4,833 children with a Dutch, Moroccan, Turkish, or Surinamese ethnic background from the Generation R Study, a population-based study in the Netherlands. Parent-reported television viewing time for children at ages 2, 3, 4, 6, and 9 years was collected by questionnaires sent from April 2004 until January 2015. Read More
PLoS One 2018 14;13(12):e0208940. Epub 2018 Dec 14.
University of Washington, Seattle, WA, United States of America.
Rationale: HSP90B1, also known as gp96, is a chaperone for multiple Toll-like receptors (TLRs) and is necessary for TLR-mediated inflammatory responses in murine myeloid cells. The molecule is also expressed in T-cells though its specific role is unknown. We hypothesized that human HSP90B1 regulates monocyte and T-cell responses to Mycobacterium tuberculosis (Mtb) and bacilli Calmette-Guerin (BCG) and that its variants are associated with susceptibility to TB disease. Read More
PLoS One 2018 14;13(12):e0200856. Epub 2018 Dec 14.
Nigeria Field Epidemiology and Laboratory Training Programme, Abuja, Nigeria.
Introduction: Early diagnosis and prompt and effective treatment is one of the pillars of malaria control. Malaria case management guidelines recommend diagnostic testing before treatment using malaria Rapid Diagnostic Test (mRDT) or microscopy and this was adopted in Nigeria in 2010. However, despite the deployment of mRDT, the use of mRDTs by health workers varies by settings. Read More
Medwave 2018 Dec 14;18(8):e7376. Epub 2018 Dec 14.
Proyecto Epistemonikos, Santiago, Chile; Departamento de Endocrinología, Facultad de Medicina, Pontificia Universidad Católica de Chile, Santiago, Chile. Email: Address: Centro Evidencia UC, Pontificia Universidad Católica de Chile, Diagonal Paraguay 476, Santiago, Chile.
Introduction: The usual supplementation for hypothyroidism is based on monotherapy with levothyroxine. However, some patients persist with symptoms attributable to the deficit of thyroid hormone. It has been suggested that the a combined treatment with liothyronine and levothyroxine would provide a greater benefit. Read More
Medwave 2018 Dec 10;18(8):e7372. Epub 2018 Dec 10.
Proyecto Epistemonikos, Santiago, Chile; Departamento de Otorrinolaringología, Facultad de Medicina, Pontificia Universidad Católica de Chile, Santiago, Chile. Email: Address: Centro Evidencia UC, Pontificia Universidad Católica de Chile, Diagonal Paraguay 476, Santiago, Chile.
Introduction: Spontaneous epistaxis is one of the most frequent problems in emergency services. New treatment alternatives have emerged, including topical tranexamic acid. However, there is controversy about the actual efficacy of this alternative. Read More
Medwave 2018 Dec 11;18(8):e7370. Epub 2018 Dec 11.
Proyecto Epistemonikos, Santiago, Chile; Centro Evidencia UC, Pontificia Universidad Católica de Chile, Santiago, Chile; Departamento de Medicina Interna, Facultad de Medicina, Pontificia Universidad Católica de Chile, Santiago, Chile. Email: Address: Centro Evidencia UC, Pontificia Universidad Católica de Chile, Diagonal Paraguay 476, Santiago, Chile.
Introduction: The treatment of acute appendicitis using laparoscopy reduces the risk of wound infection, hospitalization time and return to normal activity. However, it increases the risk of intra-abdominal abscess, which is one the main complications of complicated appendicitis.
Methods: We searched in Epistemonikos, the largest database of systematic reviews in health, which is maintained by screening multiple information sources, including MEDLINE, EMBASE, Cochrane, among others. Read More
Ophthalmic Plast Reconstr Surg 2018 Dec 7. Epub 2018 Dec 7.
Eye Research Center, Rassoul Akram Hospital, Iran University of Medical Sciences, Tehran, Iran.
Purpose: To compare preoperative and postoperative lower eyelid scleral show in patients with unilateral myogenic (MP) and aponeurotic (AP) ptosis, analyze the factors correlated with them, and assess the rate of postoperative lower eyelid symmetry in both groups.
Methods: Patients (older than 5 years old) with unilateral MP (58) and AP (20) were included from June 2015 to April 2017. Excluded were patients with previous eyelid surgery, strabismus, levator function of ≤3, and associated procedures. Read More