704 results match your criteria Multiple Sclerosis Spine


Surgical management of patients with coexistent multiple sclerosis and cervical stenosis: A systematic review and meta-analysis.

J Clin Neurosci 2019 Apr 20. Epub 2019 Apr 20.

Department of Neurological Surgery, UCSF Medical Center, San Francisco, CA, United States. Electronic address:

Multiple sclerosis (MS) and cervical stenosis (CS) are two unique pathologies that can present with overlapping symptoms. In patients with concurrent MS and CS, the exact cause for worsening of symptoms is often difficult to decipher. In this study, we aimed to review the medical literature on the benefits of surgical decompression surgery in patients with coexisting CS and MS. Read More

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http://dx.doi.org/10.1016/j.jocn.2019.04.001DOI Listing

Turning Feed-forward and Feedback Processes on Patient-reported Data into Intelligent Action and Informed Decision-making: Case Studies and Principles.

Med Care 2019 May;57 Suppl 5 Suppl 1:S31-S37

Patient Reported Outcomes, Dartmouth Hitchcock Medical Center.

Introduction: The collection of patient-reported outcomes (PROs) in routine clinical practice provides opportunities to "feed-forward" the patient's perspective to his/her clinical team to inform planning and management. This data can also be aggregated to "feedback" population-level analytics that can inform treatment decision-making, predictive modeling, population-based care, and system-level quality improvement efforts.

Methods Aiding Interpretation And Acting On Results: Three case studies demonstrate a number of system-level features which aid effective PRO interpretation: (1) feed-forward and feedback information flows; (2) score interpretation aids; (3) cascading measurement; (4) registry-enabled learning health care systems; and (5) the maturational development of information systems. Read More

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http://dx.doi.org/10.1097/MLR.0000000000001088DOI Listing
May 2019
2 Reads

Impact of red meat, processed meat and fibre intake on risk of late-onset chronic inflammatory diseases: prospective cohort study on lifestyle factors using the Danish 'Diet, Cancer and Health' cohort (PROCID-DCH): .

BMJ Open 2019 Mar 30;9(3):e024555. Epub 2019 Mar 30.

Focused Research Unit for Molecular Diagnostic and Clinical Research, Hospital of Southern Jutland, Aabenraa, Denmark.

Introduction: Chronic inflammatory diseases (CIDs) (Crohn's disease, ulcerative colitis, psoriasis, psoriatic arthritis, rheumatoid arthritis and multiple sclerosis) are diseases of the immune system that have some shared genetic and environmental predisposing factors, but still few studies have investigated the effects of lifestyle on disease risk of several CIDs. The primary aim of this prospective cohort study is to investigate the impact of fibre, red meat and processed meat on risk of late-onset CID, with the perspective that results of this study can contribute in supporting future diet recommendations for effective personalised prevention.

Methods And Analysis: The study will use data from 57 053 persons from the prospective Danish cohort study 'Diet, Cancer and Health' together with National Health Registry data. Read More

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http://dx.doi.org/10.1136/bmjopen-2018-024555DOI Listing
March 2019
2 Reads

An extremely aggressive case of Marburg's disease treated with high dose cyclophosphamide. A case report.

Mult Scler Relat Disord 2019 Mar 23;31:51-53. Epub 2019 Mar 23.

Division of Neurology, University of Puerto Rico School of Medicine, PO Box 365067, San Juan, Puerto Rico, 00936-5067.

Background: The acute, fulminant type of Multiple Sclerosis (MS), known as Marburg Disease, has been shown to have poor response to conventional acute treatments typically used for demyelinating diseases.

Methods: We report a 20 y/o postpartum female who was consulted to the Neurology service given findings of subacute left sided hemiparesis, left homonymous hemianopsia and bilateral papilledema. Extensive workup, including Brain and Cervical spine MRI with and without gadolinium, blood work, CSF studies, in addition to her rapid clinical decline, were highly suggestive of the demyelinating variant of Multiple Sclerosis known as Marburg Disease. Read More

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http://dx.doi.org/10.1016/j.msard.2019.03.014DOI Listing
March 2019
1 Read

Therapeutic Inhibition of the Complement System in Diseases of the Central Nervous System.

Front Immunol 2019 4;10:362. Epub 2019 Mar 4.

UK Dementia Research Institute, Cardiff University, Cardiff, United Kingdom.

The complement system plays critical roles in development, homeostasis, and regeneration in the central nervous system (CNS) throughout life; however, complement dysregulation in the CNS can lead to damage and disease. Complement proteins, regulators, and receptors are widely expressed throughout the CNS and, in many cases, are upregulated in disease. Genetic and epidemiological studies, cerebrospinal fluid (CSF) and plasma biomarker measurements and pathological analysis of post-mortem tissues have all implicated complement in multiple CNS diseases including multiple sclerosis (MS), neuromyelitis optica (NMO), neurotrauma, stroke, amyotrophic lateral sclerosis (ALS), Alzheimer's disease (AD), Parkinson's disease (PD), and Huntington's disease (HD). Read More

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http://dx.doi.org/10.3389/fimmu.2019.00362DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6409326PMC
March 2019
1 Read

Daclizumab: Mechanisms of Action, Therapeutic Efficacy, Adverse Events and Its Uncovering the Potential Role of Innate Immune System Recruitment as a Treatment Strategy for Relapsing Multiple Sclerosis.

Biomedicines 2019 Mar 11;7(1). Epub 2019 Mar 11.

Providence Health and Services, Regional Research Department, Portland, OR 97213, USA.

Daclizumab (DAC) is a humanized, monoclonal antibody that blocks CD25, a critical element of the high-affinity interleukin-2 receptor (IL-2R). DAC HYP blockade of CD25 inhibits effector T cell activation, regulatory T cell expansion and survival, and activation-induced T-cell apoptosis. Because CD25 blockade reduces IL-2 consumption by effector T cells, it increases IL-2 bioavailability allowing for greater interaction with the intermediate-affinity IL-2R, and therefore drives the expansion of CD56 natural killer (NK) cells. Read More

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http://dx.doi.org/10.3390/biomedicines7010018DOI Listing
March 2019
2 Reads

A Case of Autosomal Dominant Osteopetrosis Type II with a Gene Mutation

J Clin Res Pediatr Endocrinol 2019 Feb 14. Epub 2019 Feb 14.

Department of Pediatrics1, Korea Cancer Center Hospital, Seoul 139-706, Republic of Korea

Osteopetrosis is a rare genetic disease characterized by increased bone density and bone breakage due to defective osteoclast function. Autosomal dominant osteopetrosis type II, Albers-Schonberg disease, is characterized by the sclerosis of bones, predominantly involving the spine, pelvis, and the base of the skull. Here, we report a typical case of osteopetrosis in a 17. Read More

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http://dx.doi.org/10.4274/jcrpe.galenos.2019.2018.0229DOI Listing
February 2019
4 Reads

Fibrinogen Induces Microglia-Mediated Spine Elimination and Cognitive Impairment in an Alzheimer's Disease Model.

Neuron 2019 Mar 5;101(6):1099-1108.e6. Epub 2019 Feb 5.

Gladstone Institute of Neurological Disease, San Francisco, CA 94158, USA; Department of Neurology, University of California, San Francisco, San Francisco, CA 94158, USA. Electronic address:

Cerebrovascular alterations are a key feature of Alzheimer's disease (AD) pathogenesis. However, whether vascular damage contributes to synaptic dysfunction and how it synergizes with amyloid pathology to cause neuroinflammation and cognitive decline remain poorly understood. Here, we show that the blood protein fibrinogen induces spine elimination and promotes cognitive deficits mediated by CD11b-CD18 microglia activation. Read More

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http://dx.doi.org/10.1016/j.neuron.2019.01.014DOI Listing
March 2019
2 Reads

Reducing return of disease activity in patients with relapsing multiple sclerosis transitioned from natalizumab to teriflunomide: 12-month interim results of teriflunomide therapy.

Mult Scler J Exp Transl Clin 2019 Jan-Mar;5(1):2055217318824618. Epub 2019 Jan 16.

Regional Research, Providence Health and Services, USA.

Background: Natalizumab is an effective treatment for relapsing multiple sclerosis. Return of disease activity upon natalizumab discontinuance creates the need for follow-up therapeutic strategies.

Objective: To assess the efficacy of teriflunomide following natalizumab discontinuance in relapsing multiple sclerosis patients. Read More

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http://dx.doi.org/10.1177/2055217318824618DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6350141PMC
January 2019
2 Reads

Spatial distribution of multiple sclerosis lesions in the cervical spinal cord.

Brain 2019 Mar;142(3):633-646

NeuroPoly Lab, Institute of Biomedical Engineering, Polytechnique Montreal, Montreal, QC, Canada.

Spinal cord lesions detected on MRI hold important diagnostic and prognostic value for multiple sclerosis. Previous attempts to correlate lesion burden with clinical status have had limited success, however, suggesting that lesion location may be a contributor. Our aim was to explore the spatial distribution of multiple sclerosis lesions in the cervical spinal cord, with respect to clinical status. Read More

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https://academic.oup.com/brain/advance-article/doi/10.1093/b
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http://dx.doi.org/10.1093/brain/awy352DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6391605PMC
March 2019
15 Reads
9.196 Impact Factor

Real-World Characterization of Dimethyl Fumarate-Related Gastrointestinal Events in Multiple Sclerosis: Management Strategies to Improve Persistence on Treatment and Patient Outcomes.

Neurol Ther 2019 Jan 31. Epub 2019 Jan 31.

Department of Neurology, Inselspital-Bern University Hospital, University of Bern, Bern, Switzerland.

Introduction: Delayed-release dimethyl fumarate (DMF) is an effective treatment for multiple sclerosis (MS). Some patients experience gastrointestinal (GI) adverse events (AEs) that may lead to premature DMF discontinuation. This study characterized the impact of site-specific GI management strategies on the occurrence of GI events and discontinuation patterns. Read More

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http://dx.doi.org/10.1007/s40120-019-0127-2DOI Listing
January 2019
1 Read

Frequency, type, distribution of pain and related factors in persons with multiple sclerosis.

Mult Scler Relat Disord 2019 Feb 3;28:221-225. Epub 2019 Jan 3.

Department of Neurology, Faculty of Medicine, Dokuz Eylül University, Izmir, Turkey.

Background: Although there is accumulating evidence on neuropathic pain in persons with multiple sclerosis (pwMS), little is known about musculoskeletal pain. The aim was to examine the frequency, type, distribution of pain and related factors in pwMS.

Methods: This cross-sectional study included 223 pwMS. Read More

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http://dx.doi.org/10.1016/j.msard.2019.01.002DOI Listing
February 2019
3 Reads

Gray vs. White Matter Segmentation of the Conus Medullaris: Reliability and Variability in Healthy Volunteers.

J Neuroimaging 2018 Dec 24. Epub 2018 Dec 24.

NMR Research Unit, Queen Square MS Centre, Department of Neuroinflammation, UCL Institute of Neurology, University College London, London, United Kingdom.

Background And Purpose: Magnetic resonance imaging (MRI)-derived spinal cord (SC) gray and white matter (GM/WM) volume are useful indirect measures of atrophy and neurodegeneration over time, typically obtained in the upper SC. Neuropathological evidence suggests that in certain neurological conditions, early degeneration may occur as low as the sacral SC. In this study, the feasibility of GM/WM segmentation of the conus medullaris (CM) was assessed in vivo. Read More

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http://dx.doi.org/10.1111/jon.12591DOI Listing
December 2018
6 Reads

Clinical, Radiologic, and Prognostic Features of Myelitis Associated With Myelin Oligodendrocyte Glycoprotein Autoantibody.

JAMA Neurol 2018 Dec 21. Epub 2018 Dec 21.

Department of Neurology, Mayo Clinic College of Medicine, Rochester, Minnesota.

Importance: Recognizing the characteristics of myelin oligodendrocyte glycoprotein autoantibody (MOG-IgG) myelitis is essential for early accurate diagnosis and treatment.

Objective: To evaluate the clinical, radiologic, and prognostic features of MOG-IgG myelitis and compare with myelitis with aquaporin-4-IgG (AQP4-IgG) and multiple sclerosis (MS).

Design, Setting, And Participants: We retrospectively identified 199 MOG-IgG-positive Mayo Clinic patients from January 1, 2000, through December 31, 2017, through our neuroimmunology laboratory. Read More

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http://dx.doi.org/10.1001/jamaneurol.2018.4053DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6440233PMC
December 2018
6 Reads

Acute hypertensive uveitis as the first presentation of multiple sclerosis.

Indian J Ophthalmol 2019 Jan;67(1):163-164

Department of Ophthalmology, The Queen Elizabeth Hospital; Department of Ophthalmology, The Royal Adelaide Hospital; The South Australian Institute of Ophthalmology, Adelaide, South Australia, Australia.

Ophthalmic manifestations of multiple sclerosis are frequent including acute optic neuritis, ocular motor disturbances and intermediate uveitis. We report an unusual case of multiple sclerosis presenting as acute hypertensive uveitis. A 56-year-old man was referred by his family doctor with a 2-week history of right eye pain and decreased vision. Read More

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http://dx.doi.org/10.4103/ijo.IJO_345_18DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6324108PMC
January 2019
3 Reads

Magnetic resonance imaging in enterovirus-71, myelin oligodendrocyte glycoprotein antibody, aquaporin-4 antibody, and multiple sclerosis-associated myelitis in children.

Dev Med Child Neurol 2018 Dec 10. Epub 2018 Dec 10.

Neuroimmunology Group, Institute for Neuroscience and Muscle Research, The Kids Research Institute, Children's Hospital at Westmead, Sydney Medical School, University of Sydney, Sydney, New South Wales, Australia.

Aim: We used magnetic resonance imaging (MRI) to compare the neuroimaging of children with their first episode of clinical enterovirus 71-associated transverse myelitis (EV71-TM), myelin oligodendrocyte glycoprotein antibody positive transverse myelitis (MOG-TM), aquaporin-4 antibody positive transverse myelitis (AQP4-TM), transverse myelitis in multiple sclerosis (MS-TM), and unclassified transverse myelitis (UNC-TM).

Method: We performed a retrospective blinded radiological assessment and compared the neuroimaging of 52 children (32 females, 20 males; mean age 9y 8mo, SD 5y 5mo, range 5mo-17y) presenting with their first episode of myelitis caused by EV71-TM (n=11), MOG-TM (n=10), AQP4-TM (n=9), MS-TM (n=13), and UNC-TM (n=9).

Results: In the EV71-TM group, lesions were distributed throughout the cord and enhancement of nerve roots (ventral and dorsal) was common. Read More

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http://dx.doi.org/10.1111/dmcn.14114DOI Listing
December 2018
1 Read

Ultrahigh field imaging of myelin disease models: Toward specific markers of myelin integrity?

J Comp Neurol 2018 Dec 6. Epub 2018 Dec 6.

Sorbonne Université, UPMC Paris 06, Brain and Spine Institute, ICM, Hôpital de la Pitié Salpêtrière, Paris, France.

Specific magnetic resonance imaging (MRI) markers of myelin are critical for the evaluation and development of regenerative therapies for demyelinating diseases. Several MRI methods have been developed for myelin imaging, based either on acquisition schemes or on mathematical modeling of the signal. They generally showed good sensitivity but validation for specificity toward myelin is still warranted to allow a reliable interpretation in an in vivo complex pathological environment. Read More

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http://dx.doi.org/10.1002/cne.24598DOI Listing
December 2018
3 Reads

Single-stage anterior debridement, posterior instrumentation and global fusion in thoracic and thoracolumbar tubercular spondylodiscitis.

Musculoskelet Surg 2018 Dec 4. Epub 2018 Dec 4.

Department of Orthopaedics, Division of Spine Surgery, Kasturba Medical College, Manipal Academy of Higher Education, Manipal, 576-104, Karnataka, India.

Purpose: The present study evaluated the clinical and radiological outcomes in patients with tuberculosis of the thoracic and thoracolumbar spine, treated by an operative technique in which anterior debridement with posterior instrumentation and global fusion was performed through a single-stage posterior approach.

Methods: Ninty-seven patients with spinal tuberculosis, between T1 and L1, in whom anterior debridement, bone grafting, with posterior instrumentation and fusion was performed through a single-stage posterior approach, with a minimum follow-up of 2 years, formed the basis of this study. During each follow-up, neurological recovery was assessed using modified American Spinal Injury Association grading, healing of the disease was assessed by appearance of sclerosis and interbody fusion and the degree of kyphotic deformity was analysed using the modified Konstam's angle. Read More

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http://dx.doi.org/10.1007/s12306-018-0581-5DOI Listing
December 2018
3 Reads

[Experience with mexidol in neurological practice].

Zh Nevrol Psikhiatr Im S S Korsakova 2018;118(10):97-107

Federal State Autonomous Institution 'National Medical Research Center for Neurosurgery named after Academician N.N. Burdenko' of the Ministry of Health of the Russian Federation, Moscow, Russia.

Antihypoxic, antioxidant and nootropic effects of mexidol contribute to the improvement of patients with cerebrovascular pathology. The results of clinical studies show that the sequential scheme of using mexidol (first i.v. Read More

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http://dx.doi.org/10.17116/jnevro201811810197DOI Listing
March 2019
26 Reads

Differences in Intercellular Communication During Clinical Relapse and Gadolinium-Enhanced MRI in Patients With Relapsing Remitting Multiple Sclerosis: A Study of the Composition of Extracellular Vesicles in Cerebrospinal Fluid.

Front Cell Neurosci 2018 15;12:418. Epub 2018 Nov 15.

Department of Experimental Biomedicine and Clinical Neuroscience, University of Palermo, Palermo, Italy.

This study was designed based on the hypothesis that changes in both the levels and surface marker expression of extracellular vesicles (EVs) isolated from the cerebrospinal fluid (CSF) may be associated with the clinical form, disease activity, and severity of multiple sclerosis (MS). The analyzes were performed on subjects affected by MS or other neurological disorders. EVs, which were isolated by ultracentrifugation of CSF samples, were characterized by flow cytometry. Read More

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https://www.frontiersin.org/article/10.3389/fncel.2018.00418
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http://dx.doi.org/10.3389/fncel.2018.00418DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6249419PMC
November 2018
13 Reads

Athletes with neurologic disease.

Handb Clin Neurol 2018 ;158:445-462

Sports Medicine Institute, Sandra and Malcolm Berman Brain and Spine Institute at LifeBridge Health, Baltimore, MD, United States. Electronic address:

Neurologic disease does not discriminate, even among athletes. Common neurologic diseases among athletes include multiple sclerosis, seizures, headaches, and sleep disorders. Although concrete guidelines for sport participation among athletes with neurologic diseases do not exist, evidence-based and consensus statements can aid healthcare providers in determining whether and to what extent such athletes should participate in sports. Read More

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http://dx.doi.org/10.1016/B978-0-444-63954-7.00041-0DOI Listing
March 2019
2 Reads

Microsurgical Decompression of Trigeminal Neuralgia Caused by Simultaneous Double Arterial (SCA and AICA) and Petrosal Vein Complex Compression.

J Neurol Surg B Skull Base 2018 Dec 25;79(Suppl 5):S428-S430. Epub 2018 Sep 25.

Semmes Murphey Neurologic and Spine Institute, Memphis, Tennessee, United States.

Trigeminal neuralgia is a chronic pain disorder affecting the face. In approximately 80% of cases, it is most commonly caused, when the root entry zone (REZ) of the trigeminal nerve is compressed by the superior cerebellar artery (SCA). The etiology of the remaining 20% of cases is distributed among venous, arteriovenous malformations, posterior fossa tumors, multiple sclerosis plaque compressions, and other pathologies. Read More

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http://www.thieme-connect.de/DOI/DOI?10.1055/s-0038-1669968
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http://dx.doi.org/10.1055/s-0038-1669968DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6243231PMC
December 2018
10 Reads

Multiple Critical Periods for Rapamycin Treatment to Correct Structural Defects in -Suppressed Brain.

Front Mol Neurosci 2018 8;11:409. Epub 2018 Nov 8.

Department of Brain and Cognitive Science, Massachusetts Institute of Technology, Cambridge, MA, United States.

Tuberous sclerosis complex (TSC) is an autosomal dominant neurogenetic disorder affecting the brain and other vital organs. Neurological symptoms include epilepsy, intellectual disability, and autism. TSC is caused by a loss-of-function mutation in the or gene. Read More

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http://dx.doi.org/10.3389/fnmol.2018.00409DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6237075PMC
November 2018
27 Reads

Dysexecutive disorders and their diagnosis: A position paper.

Cortex 2018 Dec 17;109:322-335. Epub 2018 Oct 17.

Department of Neurology and Laboratory of Functional Neurosciences (EA 4559), University Hospital of Amiens, France.

Although executive function disorders are among the most prevalent cognitive impairments a consensus on diagnostic criteria has yet to be reached. With a view to harmonizing these criteria, the present position paper (i) focuses on the main dysexecutive disorders, (ii) examines recent approaches in both the behavioral and cognitive domains, (iii) defines diagnostic boundaries for frontal syndrome, (iv) reports on the frequency and profile of the executive function disorders observed in the main brain diseases, and (v) proposes an operationalization of diagnostic criteria. Future work must define the executive processes involved in human adaptive behavior, characterize their impairment in brain diseases, and improve the management of these conditions (including remediation strategies and rehabilitation). Read More

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https://linkinghub.elsevier.com/retrieve/pii/S00109452183033
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http://dx.doi.org/10.1016/j.cortex.2018.09.026DOI Listing
December 2018
49 Reads
5.130 Impact Factor

Paraneoplastic neuromyelitis optica associated with fever of unknown origin as an early manifestation: A case report.

Mult Scler Relat Disord 2019 Jan 2;27:200-202. Epub 2018 Nov 2.

Isfahan University of medical science, Isfahan, Iran.

Tumors have been frequently reported to be associated with neuromyelitis optica (NMO). Here we review a case of a 34-year-old woman who presented with complaint of one-sided visual loss. All Lab tests exhibited negative results which decreased the possibility of Auto-immune or neuro-inflammatory disorders. Read More

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https://linkinghub.elsevier.com/retrieve/pii/S22110348183048
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http://dx.doi.org/10.1016/j.msard.2018.10.118DOI Listing
January 2019
12 Reads

Breathlessness in amyotrophic lateral sclerosis: A case report on the role of osteoporosis in the worsening of respiratory failure.

Medicine (Baltimore) 2018 Nov;97(45):e13026

IRCCS Centro Neurolesi "Bonino Pulejo," Messina, Italy.

Rationale: Amyotrophic lateral sclerosis (ALS) is a progressive neurodegenerative multisystem disorder, presenting with limb or bulbar onset. To date, there is no cure for ALS. At some stage of the disease, patients may complain of breathlessness due to respiratory failure, thus needing a noninvasive mechanical ventilation (NIMV) support. Read More

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http://Insights.ovid.com/crossref?an=00005792-201811090-0001
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http://dx.doi.org/10.1097/MD.0000000000013026DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6250541PMC
November 2018
27 Reads

A Novel Insight Into the Challenges of Diagnosing Degenerative Cervical Myelopathy Using Web-Based Symptom Checkers.

J Med Internet Res 2019 Jan 11;21(1):e10868. Epub 2019 Jan 11.

Academic Neurosurgery Unit, Department of Clinical Neurosciences, University of Cambridge, Cambridge, United Kingdom.

Background: Degenerative cervical myelopathy (DCM) is a common debilitating condition resulting from degeneration of the cervical spine. While decompressive surgery can halt disease progression, existing spinal cord damage is often permanent, leaving patients with lifelong disability. Early surgery improves the likelihood of recovery, yet the average time from the onset of symptoms to correct diagnosis is over 2 years. Read More

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http://preprints.jmir.org/preprint/10868/accepted
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http://dx.doi.org/10.2196/10868DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6330198PMC
January 2019
2 Reads

Thigh-Derived Inertial Sensor Metrics to Assess the Sit-to-Stand and Stand-to-Sit Transitions in the Timed Up and Go (TUG) Task for Quantifying Mobility Impairment in Multiple Sclerosis.

Front Neurol 2018 14;9:684. Epub 2018 Sep 14.

Molekulare Neurologie, Universitätsklinikum Erlangen, Erlangen, Germany.

Inertial sensors generate objective and sensitive metrics of movement disability that may indicate fall risk in many clinical conditions including multiple sclerosis (MS). The Timed-Up-And-Go (TUG) task is used to assess patient mobility because it incorporates clinically-relevant submovements during standing. Most sensor-based TUG research has focused on the placement of sensors at the spine, hip or ankles; an examination of thigh activity in TUG in multiple sclerosis is wanting. Read More

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https://www.frontiersin.org/article/10.3389/fneur.2018.00684
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http://dx.doi.org/10.3389/fneur.2018.00684DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6149240PMC
September 2018
8 Reads

Assessment of Biochemical and Densitometric Markers of Calcium-Phosphate Metabolism in the Groups of Patients with Multiple Sclerosis Selected due to the Serum Level of Vitamin D.

Biomed Res Int 2018 23;2018:9329123. Epub 2018 Aug 23.

Department of Neurology, SMDZ in Zabrze, Medical University of Silesia in Katowice, ul. 3-go Maja 13-15, 41-800 Zabrze, Poland.

Background: In addition to the widely known effect of vitamin D (vitD) on the skeleton, its role in the regulation of the immune response was also confirmed.

Aim: The assessment of biochemical and densitometric markers of calcium-phosphate metabolism in the groups of patients with relapsing-remitting multiple sclerosis (RRMS) selected due to the serum level of vitamin D.

Methods: The concentrations of biochemical markers and indices of lumbar spine bone densitometry (DXA) were determined in 82 patients divided into vitamin D deficiency (VitDd), insufficiency (VitDi), and normal vitamin D level (VitDn) subgroups. Read More

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http://dx.doi.org/10.1155/2018/9329123DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6126066PMC
January 2019
3 Reads

[Demyelinating disorders].

Authors:
Andrea Savransky

Medicina (B Aires) 2018;78 Suppl 2:75-81

Hospital de Pediatría Prof. Dr. Juan P. Garrahan, Buenos Aires, Argentina. E-mail:

Demyelinating diseases are a group of conditions of autoimmune etiology directed against the myelin of the central nervous system. In many cases, the onset of the illness is preceded by a nonspecific viral infection. Multiple sclerosis is a disease that evolves with relapses and remissions with polyfocal neurological deficits, being the most frequent optic neuritis, transverse myelitis and encephalic trunk involvement. Read More

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March 2019
6 Reads

Neuromyelitis optica spectrum disorder presenting in an octogenarian.

BMJ Case Rep 2018 Sep 8;2018. Epub 2018 Sep 8.

Medicine of the Elderly Department, Royal Infirmary of Edinburgh, Edinburgh, UK.

This case describes an 81-year-old woman with a history of Sjögren's syndrome presenting with recurrent falls and poor balance. She subsequently developed new and rapidly evolving neurology including hyperaesthesia, spastic paraplegia and sphincteric dysfunction. Following serial clinical reviews and detailed investigations, MRI (brainstem and cervicothoracic spine) and a seropositive result for aquaporin 4 IgG, a diagnosis of neuromyelitis optica spectrum disorder (NMOSD) was made. Read More

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http://casereports.bmj.com/lookup/doi/10.1136/bcr-2018-22560
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http://dx.doi.org/10.1136/bcr-2018-225601DOI Listing
September 2018
33 Reads

Reduced Microglial Activity and Enhanced Glutamate Transmission in the Basolateral Amygdala in Early CNS Autoimmunity.

J Neurosci 2018 Oct 5;38(42):9019-9033. Epub 2018 Sep 5.

Hotchkiss Brain Institute, University of Calgary, Calgary, Alberta T2N 4N1, Canada,

Emotional dysfunction is common in multiple sclerosis (MS) patients and in mouse models of MS, including experimental autoimmune encephalomyelitis (EAE); however, the etiology of these behaviors is poorly understood. To identify CNS changes associated with these behaviors, we focused on the basolateral amygdala (BLA) because of its central role in the regulation of emotional behavior. Whole-cell recordings were performed in the principal neurons of the BLA in early EAE, before demyelination, T-cell invasion, and motor dysfunction. Read More

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http://dx.doi.org/10.1523/JNEUROSCI.0398-18.2018DOI Listing
October 2018
2 Reads

Cervical MRI Rating Scale: Innovative Approach to Differentiate between Demyelinating and Disc Lesions.

Clin Neuroradiol 2018 Aug 23. Epub 2018 Aug 23.

Multiple Sclerosis Center, Sheba Medical Center, Tel Hashomer, Israel.

Purpose: The difficult differentiation between multiple sclerosis (MS) lesions and cervical spondylotic myelopathy (CSM) in the cervical spine is well known. The magnetic resonance imaging (MRI) appearance of both lesions is similar, and clinical parameters are usually used for diagnosis. The objective was to establish a reliable radiologic paradigm for diagnosis of demyelinating lesions in the cervical spine. Read More

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http://dx.doi.org/10.1007/s00062-018-0721-1DOI Listing
August 2018
3 Reads

Imaging features and differential diagnosis of multiple diaphyseal sclerosis: A case report and review of literature.

Medicine (Baltimore) 2018 Aug;97(33):e11725

Department of Spine Surgery, The First Affiliated Hospital of Guangzhou University of Chinese Medicine, Guangzhou, People's Republic of China.

Rationale: Multiple diaphyseal sclerosis (MDS), known as Ribbing disease, is a rare congenital bone disease resulting from autosomal recessive inheritance. The case study involved a 22-year-old female patient who had been diagnosed with chronic sclerosing osteomyelitis due to lack of knowledge about MDS. Previous studies reported rarely on this condition. Read More

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http://dx.doi.org/10.1097/MD.0000000000011725DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6112893PMC
August 2018
25 Reads

Dimethyl fumarate induced migrating polyarthralgias.

Joint Bone Spine 2018 Aug 3. Epub 2018 Aug 3.

CHU Gabriel-Montpied, 58, rue Montalembert, 63000 Clermont-Ferrand, France.

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http://dx.doi.org/10.1016/j.jbspin.2018.07.006DOI Listing
August 2018
3 Reads

Long-term outcome of treatment of vertebral body hemangiomas with direct ethanol injection and short-segment stabilization.

Spine J 2019 Jan 8;19(1):131-143. Epub 2018 Jun 8.

Department of Neuropathology, All India Institute of Medical Sciences, Ansari Nagar, New Delhi 110029, India.

Background: Vertebral body hemangiomas with myelopathy are difficult to manage.

Objective: The objective of this study was to evaluate the role of intraoperative ethanol embolization, surgical decompression, and instrumented short-segment fusion in vertebral hemangioma (VH) with myelopathy and long-term outcome (>24 months).

Clinical Materials And Methods: This prospective study included symptomatic VH with cord compression with myelopathy. Read More

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https://linkinghub.elsevier.com/retrieve/pii/S15299430183024
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http://dx.doi.org/10.1016/j.spinee.2018.05.015DOI Listing
January 2019
23 Reads
2.426 Impact Factor

Driven to decay: Excitability and synaptic abnormalities in amyotrophic lateral sclerosis.

Brain Res Bull 2018 06 2;140:318-333. Epub 2018 Jun 2.

Department of Physiology and Biomedical Engineering, Mayo Clinic, Rochester, MN, USA; School of Biomedical Sciences, The University of Queensland, St Lucia, Australia. Electronic address:

Amyotrophic lateral sclerosis (ALS) is the most common motor neuron (MN) disease and is clinically characterised by the death of corticospinal motor neurons (CSMNs), spinal and brainstem MNs and the degeneration of the corticospinal tract. Degeneration of CSMNs and MNs leads inexorably to muscle wastage and weakness, progressing to eventual death within 3-5 years of diagnosis. The CSMNs, located within layer V of the primary motor cortex, project axons constituting the corticospinal tract, forming synaptic connections with brainstem and spinal cord interneurons and MNs. Read More

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http://dx.doi.org/10.1016/j.brainresbull.2018.05.023DOI Listing
June 2018
5 Reads

Importance of Functional Loss of FUS in FTLD/ALS.

Front Mol Biosci 2018 3;5:44. Epub 2018 May 3.

Brain and Mind Research Center, Nagoya University, Nagoya, Japan.

Fused in sarcoma (FUS) is an RNA binding protein that regulates RNA metabolism including alternative splicing, transcription, and RNA transportation. FUS is genetically and pathologically involved in frontotemporal lobar degeneration (FTLD)/amyotrophic lateral sclerosis (ALS). Multiple lines of evidence across diverse models suggest that functional loss of FUS can lead to neuronal dysfunction and/or neuronal cell death. Read More

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http://dx.doi.org/10.3389/fmolb.2018.00044DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5943504PMC
May 2018
23 Reads

Intrathecal Baclofen Injection to Avoid Withdrawal in a Multiple Sclerosis Patient Undergoing Lumbar Spine Surgery: A Case Report.

A A Pract 2018 May;10(9):223-225

From the University of Kansas Medical Center, Kansas City, Kansas.

Spasticity of spinal or cerebral origin is frequently treated with baclofen. Treatment interruption initially results in rebound spasticity; life-threatening withdrawal symptoms may follow. Severe rebound spasticity of leg muscles occurred in a multiple sclerosis patient after a 10-hour long perioperative pause of oral baclofen intake. Read More

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http://dx.doi.org/10.1213/XAA.0000000000000668DOI Listing
May 2018
1 Read

Imaging-Assisted Diagnosis and Characteristics of Suspected Spinal Brucellosis: A Retrospective Study of 72 Cases.

Med Sci Monit 2018 Apr 29;24:2647-2654. Epub 2018 Apr 29.

Department of Spinal Surgery, Traditional Chinese Medicine Hospital of Xinjiang Uygur Autonomous Region, Urumchi, Xinjiang, China (mainland).

BACKGROUND We clarified the imaging features of Brucella spondylitis to enhance our understanding of the disease and to minimize misdiagnosis. MATERIAL AND METHODS Imaging data (X-ray, computed tomography [CT], and magnetic resonance imaging [MRI] data) of 72 Brucella spondylitis patients treated from 2010 to 2017 were retrospectively analyzed; diagnoses was made by evaluating laboratory and pathological data. RESULTS X-ray films revealed changes in intervertebral space heights, the number of lateral osteophytes, and bone destruction, which were more severe in the following order: lumbosacral vertebrae (56 cases, 77. Read More

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http://dx.doi.org/10.12659/MSM.909288DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5946739PMC
April 2018
13 Reads

Spondyloarthritis, Acute Anterior Uveitis, and Fungi: Updating the Catterall-King Hypothesis.

Front Med (Lausanne) 2018 5;5:80. Epub 2018 Apr 5.

Department of Ophthalmology, Oregon Health and Science University, Portland, OR, United States.

Spondyloarthritis is a common type of arthritis which affects mostly adults. It consists of idiopathic chronic inflammation of the spine, joints, eyes, skin, gut, and prostate. Inflammation is often asymptomatic, especially in the gut and prostate. Read More

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http://dx.doi.org/10.3389/fmed.2018.00080DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5895656PMC
April 2018
4 Reads

Occipital neuralgia associates with high cervical spinal cord lesions in idiopathic inflammatory demyelinating disease.

Cephalalgia 2019 Jan 8;39(1):21-28. Epub 2018 Apr 8.

Department of Neurology, Mayo Clinic. Rochester, MN, USA.

Background: The association of trigeminal neuralgia with pontine lesions has been well documented in multiple sclerosis, and we tested the hypothesis that occipital neuralgia in multiple sclerosis is associated with high cervical spinal cord lesions.

Methods: We retrospectively reviewed the records of 29 patients diagnosed with both occipital neuralgia and demyelinating disease by a neurologist from January 2001 to December 2014. We collected data on demographics, clinical findings, presence of C2-3 demyelinating lesions, and treatment responses. Read More

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http://dx.doi.org/10.1177/0333102418769953DOI Listing
January 2019
8 Reads

The Value of Phenotypes in Knee Osteoarthritis Research.

Authors:
Fred R T Nelson

Open Orthop J 2018 16;12:105-114. Epub 2018 Mar 16.

Department of Orthopaedics, Henry Ford Hospital, 2799 West Grand Blvd. Detroit Michigan 48202, USA.

Background: Over the past decade, phenotypes have been used to help categorize knee osteoarthritis patients relative to being subject to disease, disease progression, and treatment response. A review of potential phenotype selection is now appropriate. The appeal of using phenotypes is that they most rely on simple physical examination, clinically routine imaging, and demographics. Read More

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http://dx.doi.org/10.2174/1874325001812010105DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5859455PMC
March 2018
3 Reads

Clinical outcomes in patients with relapsing-remitting multiple sclerosis who switch from natalizumab to delayed-release dimethyl fumarate: A multicenter retrospective observational study (STRATEGY).

Mult Scler Relat Disord 2018 May 26;22:27-34. Epub 2018 Feb 26.

Biogen, 225 Binney St., Cambridge, MA 02142, USA. Electronic address:

Background: Delayed-release dimethyl fumarate (DMF) may be a therapeutic option for patients with relapsing-remitting multiple sclerosis (RRMS) who are treated with natalizumab and require a change in therapy. However, there is limited information regarding predictors of favorable treatment outcomes in patients switching from natalizumab to DMF. Clinical practices and sequencing protocols vary. Read More

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http://dx.doi.org/10.1016/j.msard.2018.02.028DOI Listing
May 2018
9 Reads

Aerococcus urinae: an underestimated cause of spine infection? Case report and review of the literature.

Acta Clin Belg 2018 Dec 2;73(6):444-447. Epub 2018 Mar 2.

a Department of Internal Medicine and Infectious Diseases , Cliniques Universitaires Saint-Luc , Brussels , Belgium.

Objective And Importance: New methods of microbiology identification as MALDI-TOF MS increased the rate of Aerococci detection in microbiological samples making this germ an emerging pathogen. The purpose of this case report and literature review is to highlight the role of A. urinae in spine infection and discuss the management of this type of infection. Read More

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http://dx.doi.org/10.1080/17843286.2018.1443003DOI Listing
December 2018
7 Reads

Cervical spinal cord atrophy: An early marker of progressive MS onset.

Neurol Neuroimmunol Neuroinflamm 2018 Mar 22;5(2):e435. Epub 2018 Jan 22.

Department of Neurology (B.Z., X.G., B.M.K., B.G.W., J.-M.T., O.H.K.), Department of Radiology (B.Z., K.K.), and Department of Health Sciences Research (E.J.A.), Mayo Clinic College of Medicine, Rochester, MN; Department of Neurology (X.G.), The affiliated ZhongShan Hospital of DaLian University, LiaoNing, China; Multiple Sclerosis Center (D.P., C.J.A.), Keck School of Medicine, University of Southern California, Los Angeles; Department of Neurology (C.L.-F.), Hopital Pasteur, Nice, France; Cerrahpasa School of Medicine (A.S.), Istanbul University, Turkey; and Department of Neurology & Neurotherapeutics (D.T.O.), Clinical Center for Multiple Sclerosis, University of Texas Southwestern Medical Center, Dallas.

Objective: To assess whether cervical spinal cord atrophy heralds the onset of progressive MS.

Methods: We studied 34 individuals with radiologically isolated syndrome (RIS) and 31 patients with relapsing-remitting MS (RRMS) age matched to 25 patients within a year of onset of secondary progressive MS (SPMS). Two raters independently measured (twice per rater) the cervical spinal cord average segmental area (CASA) (mm) of axial T2-weighted images between C2 and C7 landmarks. Read More

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http://dx.doi.org/10.1212/NXI.0000000000000435DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5795903PMC
March 2018
5 Reads

A Rare Presentation of Neuromyelitis Optica Spectrum Disorders.

Clin Med Insights Case Rep 2018 5;11:1179547617752685. Epub 2018 Feb 5.

Internal Medicine Residency Program, St. Mary Medical Center and UCLA, Long Beach, CA, USA.

Neuromyelitis optica spectrum disorders (NMOSDs) are a set of demyelinating disorders that primarily target the optic nerves and the spinal cord. Previously thought to be a subset of multiple sclerosis (MS), now is recognized as a distinct entity. We present a 59-year-old female patient who was admitted for acute upper and lower extremity weakness. Read More

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http://dx.doi.org/10.1177/1179547617752685DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5802599PMC
February 2018
11 Reads

Möbius syndrome with cardiac rhabdomyomas.

Ophthalmic Genet 2018 06 16;39(3):373-376. Epub 2018 Jan 16.

b Department of Congenital Heart Center , University of Florida , Gainesville , FL , USA.

Background: Möbius syndrome is a rare congenital condition which presents not merely with 6th and 7th nerve palsies, but involves gaze paresis associated with craniofacial, limb, and other abnormalities. Heterogeneity is well known in patients with Möbius syndrome and rather than being of familial inheritance based on rare cases, it is much more recognized as a sporadic syndrome. We report an infant with features of congenital Möbius syndrome associated with cardiac rhabdomyomas in the absence of tuberous sclerosis. Read More

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http://dx.doi.org/10.1080/13816810.2017.1423336DOI Listing
June 2018
18 Reads

Glia-to-neuron transfer of miRNAs via extracellular vesicles: a new mechanism underlying inflammation-induced synaptic alterations.

Acta Neuropathol 2018 04 4;135(4):529-550. Epub 2018 Jan 4.

CNR Institute of Neuroscience, via Vanvitelli 32, 20129, Milan, Italy.

Recent evidence indicates synaptic dysfunction as an early mechanism affected in neuroinflammatory diseases, such as multiple sclerosis, which are characterized by chronic microglia activation. However, the mode(s) of action of reactive microglia in causing synaptic defects are not fully understood. In this study, we show that inflammatory microglia produce extracellular vesicles (EVs) which are enriched in a set of miRNAs that regulate the expression of key synaptic proteins. Read More

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http://dx.doi.org/10.1007/s00401-017-1803-xDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5978931PMC
April 2018
24 Reads
10.762 Impact Factor