4,313 results match your criteria Multiple Sclerosis Journal[Journal]


Iatrogenic CNS demyelination in the era of modern biologics.

Mult Scler 2019 Feb 15:1352458519828601. Epub 2019 Feb 15.

Case Western Reserve University School of Medicine, Cleveland, OH, USA; Multiple Sclerosis and Neuroimmunology Program, University Hospitals Cleveland Medical Center, Cleveland, OH, USA.

The number of reported cases of iatrogenic demyelination of the central nervous system (CNS) is on the rise. This is, in part, related to the recent expansion in the use of biologics. Review of literature from the past decade suggests that in addition to vaccines, tumor necrosis factor (TNF)-alpha inhibitors and checkpoint inhibitors are the most frequently cited inducers of central inflammation. Read More

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http://dx.doi.org/10.1177/1352458519828601DOI Listing
February 2019
1 Read

Higher EBV response is associated with more severe gray matter and lesion pathology in relapsing multiple sclerosis patients: A case-controlled magnetization transfer ratio study.

Mult Scler 2019 Feb 13:1352458519828667. Epub 2019 Feb 13.

Buffalo Neuroimaging Analysis Center, Department of Neurology, Jacobs School of Medicine and Biomedical Sciences, University at Buffalo, The State University of New York, Buffalo, NY, USA/ Center for Biomedical Imaging, Clinical and Translational Science Institute, University at Buffalo, The State University of New York, Buffalo, NY, USA.

Background:: Epstein-Barr virus (EBV) infection has been associated with higher clinical activity and risk of multiple sclerosis (MS).

Objective:: To evaluate associations between EBV-specific humoral response and magnetization transfer ratio (MTR)-derived measure in MS patients and healthy controls (HCs).

Methods:: The study included 101 MS patients (69 relapsing-remitting multiple sclerosis (RRMS) and 32 secondary-progressive multiple sclerosis (SPMS)) and 41 HCs who underwent clinical, serological, and magnetic resonance imaging (MRI) investigations. Read More

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http://dx.doi.org/10.1177/1352458519828667DOI Listing
February 2019
2 Reads

MS progression is predominantly driven by age-related mechanisms - YES.

Authors:
Antonio Scalfari

Mult Scler 2019 Feb 12:1352458518820633. Epub 2019 Feb 12.

Divisions of Brain Sciences and Experimental Medicine, Department of Medicine, Centre for Neuroscience and Charing Cross Hospital, Imperial College London, London, UK.

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http://journals.sagepub.com/doi/10.1177/1352458518820633
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http://dx.doi.org/10.1177/1352458518820633DOI Listing
February 2019
5 Reads

MS progression is predominantly driven by age-related mechanisms - Commentary.

Mult Scler 2019 Feb 12:1352458518824767. Epub 2019 Feb 12.

Department of Neurology, Mayo Clinic, Rochester, MN, USA.

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http://dx.doi.org/10.1177/1352458518824767DOI Listing
February 2019

MS progression is predominantly driven by age-related mechanisms - NO.

Mult Scler 2019 Feb 12:1352458518819712. Epub 2019 Feb 12.

Mellen Center for Multiple Sclerosis, Neurological Institute, Cleveland Clinic, Cleveland, OH, USA.

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http://dx.doi.org/10.1177/1352458518819712DOI Listing
February 2019

Effect of disease-modifying therapies on subcortical gray matter atrophy in multiple sclerosis.

Mult Scler 2019 Feb 11:1352458519826364. Epub 2019 Feb 11.

Department of Neurology, Johns Hopkins University School of Medicine, Baltimore, MD, USA.

Background:: The effects of disease-modifying therapies (DMTs) on region-specific brain atrophy in multiple sclerosis (MS) are unclear.

Objective:: To determine the effects of higher versus lower efficacy DMTs on rates of brain substructure atrophy in MS.

Methods:: A non-randomized, observational cohort of people with MS followed with annual brain magnetic resonance imaging (MRI) was evaluated retrospectively. Read More

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http://dx.doi.org/10.1177/1352458519826364DOI Listing
February 2019
1 Read

The efficacy of the modified Story Memory Technique in progressive MS.

Mult Scler 2019 Feb 11:1352458519826463. Epub 2019 Feb 11.

Neuropsychology and Neuroscience Laboratory, Kessler Foundation, West Orange, NJ, USA; Department of Physical Medicine and Rehabilitation, Rutgers New Jersey Medical School, Newark, NJ, USA; Department of Neurology, Rutgers New Jersey Medical School, Newark, NJ, USA.

Background:: Impairments in new learning and memory are common in individuals with multiple sclerosis (MS), negatively impacting everyday life, including occupational and social functioning.

Objective:: This study examined the efficacy of the modified Story Memory Technique (mSMT) in a progressive multiple sclerosis (PMS) sample through a double-blind, placebo-controlled, randomized clinical trial (RCT).

Methods:: Thirty (30) individuals with PMS, naïve to the mSMT, were randomized to the treatment or placebo control group. Read More

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http://dx.doi.org/10.1177/1352458519826463DOI Listing
February 2019
1 Read

Lack of association between Toxocara canis and multiple sclerosis: A population-based case-control study.

Mult Scler 2019 Feb 11:1352458518825394. Epub 2019 Feb 11.

1 Department of Medical and Surgical Sciences and Advanced Technologies 'G.F. Ingrassia', Section of Neurosciences, University of Catania, Catania, Italy.

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http://dx.doi.org/10.1177/1352458518825394DOI Listing
February 2019
1 Read

The spectrum of spinal cord lesions in a primate model of multiple sclerosis.

Mult Scler 2019 Feb 7:1352458518822408. Epub 2019 Feb 7.

Translational Neuroradiology Section, National Institute of Neurological Disorders and Stroke, National Institutes of Health, Bethesda, MD, USA.

Background:: Experimental autoimmune encephalomyelitis (EAE) in the common marmoset is a nonhuman primate model of multiple sclerosis (MS) that shares numerous clinical, radiological, and pathological features with MS. Among the clinical features are motor and sensory deficits that are highly suggestive of spinal cord (SC) damage.

Objective:: To characterize the extent and nature of SC damage in symptomatic marmosets with EAE using a combined magnetic resonance imaging (MRI) and histopathology approach. Read More

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http://dx.doi.org/10.1177/1352458518822408DOI Listing
February 2019

Oral D-Aspartate enhances synaptic plasticity reserve in progressive multiple sclerosis.

Mult Scler 2019 Feb 7:1352458519828294. Epub 2019 Feb 7.

Multiple Sclerosis Clinical & Research Center, Department of Systems Medicine, University of Rome Tor Vergata, Rome, Italy/ Unit of Neurology, IRCCS Neuromed, Pozzilli, Italy.

Background:: Synaptic plasticity reserve correlates with clinical recovery after a relapse in relapsing-remitting forms of multiple sclerosis (MS) and is significantly compromised in patients with progressive forms of MS. These findings suggest that progression of disability in MS is linked to reduced synaptic plasticity reserve. D-Aspartate, an endogenous aminoacid approved for the use in humans as a dietary supplement, enhances synaptic plasticity in mice. Read More

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http://dx.doi.org/10.1177/1352458519828294DOI Listing
February 2019

Apathy as a herald of cognitive changes in multiple sclerosis: A 2-year follow-up study.

Mult Scler 2019 Feb 7:1352458519828296. Epub 2019 Feb 7.

Department of Psychology, University of Campania "Luigi Vanvitelli," Caserta, Italy.

Background:: Behavioral symptoms, such as apathy and depression, are common in multiple sclerosis (MS) but their relationship with cognitive and clinical characteristics often remains underinvestigated and not monitored over time.

Objective:: The aim of this study was to assess the evolution of cognitive profile of patients affected by MS in relation to apathy and depression using a 2-year follow-up study.

Methods:: Two years after the first assessment, 100 of 125 MS patients were re-evaluated on a comprehensive neuropsychological battery, and on specific scales for assessment of apathy (Apathy Evaluation Scale-Self-reported) and depression (Hamilton Depression Rating Scale). Read More

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http://dx.doi.org/10.1177/1352458519828296DOI Listing
February 2019

Early predictors of epilepsy and subsequent relapse in children with acute disseminated encephalomyelitis.

Mult Scler 2019 Feb 7:1352458518823486. Epub 2019 Feb 7.

Department of Paediatric Neurology, Great Ormond Street Hospital for Children, London, UK; Department of Neuroinflammation, Queen Square Multiple Sclerosis Centre, UCL Institute of Neurology, London, UK.

Objective:: To identify predictors of epilepsy and clinical relapses in children presenting with acute disseminated encephalomyelitis (ADEM).

Methods:: Children presenting with ADEM between 2005 and 2017 and tested clinically for MOG-Ab were identified from three tertiary paediatric neurology centres in the United Kingdom. Patients were followed up for a median of 6 years (range, 1-16 years). Read More

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http://journals.sagepub.com/doi/10.1177/1352458518823486
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http://dx.doi.org/10.1177/1352458518823486DOI Listing
February 2019
8 Reads

White-matter-nulled MPRAGE at 7T reveals thalamic lesions and atrophy of specific thalamic nuclei in multiple sclerosis.

Mult Scler 2019 Feb 7:1352458519828297. Epub 2019 Feb 7.

University of Bordeaux, Bordeaux, France; CHU de Bordeaux, Bordeaux, France; INSERM U1215, Neurocentre Magendie, Bordeaux, France.

Background:: Investigating the degeneration of specific thalamic nuclei in multiple sclerosis (MS) remains challenging.

Methods:: White-matter-nulled (WMn) MPRAGE, MP-FLAIR, and standard T1-weighted magnetic resonance imaging (MRI) were performed on MS patients ( n = 15) and matched controls ( n = 12). Thalamic lesions were counted in individual sequences and lesion contrast-to-noise ratio (CNR) was measured. Read More

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http://dx.doi.org/10.1177/1352458519828297DOI Listing
February 2019

Area postrema syndrome: Another feature of anti-GFAP encephalomyelitis.

Mult Scler 2019 Jan 21:1352458518817992. Epub 2019 Jan 21.

Lyon Neuroscience Research Center, Lyon, France.

Anti-Glial fibrillary acidic protein (GFAP) encephalomyelitis is a recently described entity and while the spectrum of this disease has been explored, further research is needed to fully describe its phenotype. Area postrema syndrome (APS) is usually associated with neuromyelitis optica spectrum disorders (NMOSDs), whereas no case of APS has been previously reported with anti-GFAP encephalomyelitis. In this article, we report a case of APS in a 41-year-old woman in the context of anti-GFAP encephalomyelitis. Read More

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http://dx.doi.org/10.1177/1352458518817992DOI Listing
January 2019
1 Read

Area postrema syndrome in autoimmune GFAP astrocytopathy.

Mult Scler 2019 Jan 21:1352458519826489. Epub 2019 Jan 21.

Department of Neurology, Mayo Clinic College of Medicine and Science, Rochester, MN, USA/Department of Laboratory Medicine and Pathology, Mayo Clinic College of Medicine and Science, Rochester, MN, USA.

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http://dx.doi.org/10.1177/1352458519826489DOI Listing
January 2019
1 Read

Severe meningo-/encephalitis after daclizumab therapy for multiple sclerosis.

Mult Scler 2019 Jan 18:1352458518819098. Epub 2019 Jan 18.

Institute of Neuropathology, University Medical Center Göttingen, Göttingen, Germany.

Background:: Daclizumab is a monoclonal antibody that binds the high-affinity interleukin-2 receptor and was approved for the treatment of relapsing multiple sclerosis. Due to severe inflammatory brain disorders, the approval was suspended in March 2018.

Objective And Methods:: This retrospective cohort study summarizes clinical, laboratory, radiological, and histological findings of seven patients who developed meningo-/encephalitis after daclizumab therapy. Read More

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http://journals.sagepub.com/doi/10.1177/1352458518819098
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http://dx.doi.org/10.1177/1352458518819098DOI Listing
January 2019
5 Reads

Imaging correlates of hand motor performance in multiple sclerosis: A multiparametric structural and functional MRI study.

Mult Scler 2019 Jan 18:1352458518822145. Epub 2019 Jan 18.

Neuroimaging Research Unit, Institute of Experimental Neurology, Division of Neuroscience, San Raffaele Scientific Institute, Vita-Salute San Raffaele University, Milan, Italy/ Department of Neurology, Institute of Experimental Neurology, Division of Neuroscience, San Raffaele Scientific Institute, Vita-Salute San Raffaele University, Milan, Italy.

Background:: Hand motor impairment has considerable effects on daily-life activities of patients with multiple sclerosis (pwMS). Understanding its anatomo-functional substrates is relevant to provide more specific therapeutic interventions.

Objectives:: To investigate the association between hand motor performance and anatomo-functional magnetic resonance imaging (MRI) abnormalities in pwMS. Read More

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http://dx.doi.org/10.1177/1352458518822145DOI Listing
January 2019
1 Read

The spectrum of acute cardiopulmonary events associated with multiple sclerosis exacerbations.

Mult Scler 2019 Jan 18:1352458518823482. Epub 2019 Jan 18.

Department of Neurology, Mayo Clinic Arizona, Scottsdale, AZ, USA.

Diverse acute neurological injuries may cause acute cardiopulmonary events including neurogenic pulmonary edema (NPE) and neurogenic stunned myocardium (NSM). The mechanism is probably mediated by sympathetic nervous system activation. Focal central nervous system (CNS) lesions, such as demyelinating lesions in multiple sclerosis (MS), may also cause cardiopulmonary disturbances. Read More

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http://dx.doi.org/10.1177/1352458518823482DOI Listing
January 2019
3 Reads

Minimal clinically important difference of improvement on the Arm Function in Multiple Sclerosis Questionnaire (AMSQ).

Mult Scler 2019 Jan 18:1352458518823489. Epub 2019 Jan 18.

Department of Neurology, Amsterdam Neuroscience, MS Center Amsterdam, Amsterdam UMC, Amsterdam, The Netherlands.

Background:: The Arm Function in Multiple Sclerosis Questionnaire (AMSQ) has been developed to assess upper extremity function of patients with multiple sclerosis (MS). A minimal clinically important difference (MCID) value has not been determined yet.

Objective:: The objective of this study is to determine an MCID for AMSQ. Read More

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http://dx.doi.org/10.1177/1352458518823489DOI Listing
January 2019
1 Read

The role of infections in multiple sclerosis.

Mult Scler 2019 Jan 14:1352458518823940. Epub 2019 Jan 14.

Department of Neurology, FLENI, Buenos Aires, Argentina; Center for Research on Neuroimmunological Diseases, FLENI, Buenos Aires, Argentina.

Several lines of evidence suggest that multiple sclerosis (MS), like other autoimmune diseases, may be triggered by microbial infections. Pathogens associated with development or exacerbation of MS include bacteria, such as Chlamydia pneumoniae, Staphylococcus aureus-produced enterotoxins that function as superantigens, and viruses of the Herpesviridae (Epstein-Barr virus and human herpes virus 6) and human endogenous retrovirus families. However, to date, no single pathogen has been accepted as causal agent. Read More

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http://dx.doi.org/10.1177/1352458518823940DOI Listing
January 2019
2 Reads

Instead of tweaking the diagnostic criteria for MS in those with CIS, we should develop diagnostic criteria that distinguish MS from other conditions - Commentary.

Authors:
Franz Fazekas

Mult Scler 2019 Jan 11:1352458518820700. Epub 2019 Jan 11.

Department of Neurology, Medical University of Graz, Graz, Austria.

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http://journals.sagepub.com/doi/10.1177/1352458518820700
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http://dx.doi.org/10.1177/1352458518820700DOI Listing
January 2019
3 Reads

Instead of tweaking the diagnostic criteria for MS in those with CIS, we should develop diagnostic criteria that distinguish MS from other conditions - Yes.

Authors:
Andrew J Solomon

Mult Scler 2019 Jan 11:1352458518813107. Epub 2019 Jan 11.

Multiple Sclerosis and Department of Neurological Sciences, Larner College of Medicine, The University of Vermont and The University of Vermont Medical Center, Burlington, VT, USA.

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http://dx.doi.org/10.1177/1352458518813107DOI Listing
January 2019
1 Read

Instead of tweaking the diagnostic criteria for MS in those with CIS, we should develop diagnostic criteria that distinguish MS from other conditions - No.

Mult Scler 2019 Jan 11:1352458518819379. Epub 2019 Jan 11.

Queen Square Multiple Sclerosis Centre, Department of Neuroinflammation, UCL Queen Square Institute of Neurology, London, UK/National Hospital for Neurology and Neurosurgery, London, UK.

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http://dx.doi.org/10.1177/1352458518819379DOI Listing
January 2019
1 Read

Structural connectivity in multiple sclerosis and modeling of disconnection.

Mult Scler 2019 Jan 9:1352458518820759. Epub 2019 Jan 9.

Neuroimaging Research Unit, Institute of Experimental Neurology, Division of Neuroscience, San Raffaele Scientific Institute, Vita-Salute San Raffaele University, Milan, Italy/Department of Neurology, San Raffaele Scientific Institute, Vita-Salute San Raffaele University, Milan, Italy.

Background:: Multiple sclerosis (MS) is characterized by focal white matter damage, and when the brain is modeled as a network, lesions can be treated as disconnection events.

Objective:: To evaluate whether modeling disconnection caused by lesions helps explain motor and cognitive impairment in MS.

Methods:: Pathways connecting 116 cortical regions were reconstructed with magnetic resonance imaging (MRI) tractography from diffusion tensors averaged across healthy controls (HCs); maps of pathways were applied to 227 relapse-onset MS patients and 50 HCs to derive structural connectivity. Read More

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http://dx.doi.org/10.1177/1352458518820759DOI Listing
January 2019
1 Read

Lower total cerebral arterial flow contributes to cognitive performance in multiple sclerosis patients.

Mult Scler 2019 Jan 9:1352458518819608. Epub 2019 Jan 9.

Buffalo Neuroimaging Analysis Center, Department of Neurology, Jacobs School of Medicine and Biomedical Sciences, University at Buffalo, The State University of New York, Buffalo, NY, USA/Center for Biomedical Imaging, Clinical Translational Science Institute, University at Buffalo, The State University of New York, Buffalo, NY, USA.

Background:: The cognitive performance in multiple sclerosis (MS) patients declines with aging, longer disease duration, and possibly cardiovascular comorbidities.

Objectives:: We investigated whether lower total cerebral arterial blood flow (CABF) measured at the level of the carotid and vertebral arteries may contribute to worse cognitive performance in 132 MS patients and 47 healthy controls.

Methods:: Total CABF was evaluated with extracranial Doppler, whereas structural T2-lesion volume (LV) and gray matter volume (GMV) were measured on 3T MRI. Read More

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http://dx.doi.org/10.1177/1352458518819608DOI Listing
January 2019
6 Reads

Trait Conscientiousness predicts rate of longitudinal SDMT decline in multiple sclerosis.

Mult Scler 2019 Jan 7:1352458518820272. Epub 2019 Jan 7.

Jacobs Multiple Sclerosis Center, Department of Neurology, School of Medicine and Biomedical Sciences, University at Buffalo, The State University of New York, Buffalo, NY, USA.

Background:: Many people with multiple sclerosis (MS) exhibit cognitive decline over several years. Baseline differences may put people at greater risk for such decline.

Objective:: To characterize rates of longitudinal cognitive decline and investigate baseline clinical predictors. Read More

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http://dx.doi.org/10.1177/1352458518820272DOI Listing
January 2019
5 Reads

Serum glial fibrillary acidic protein correlates with multiple sclerosis disease severity.

Mult Scler 2018 Dec 20:1352458518819380. Epub 2018 Dec 20.

Turku PET Centre, Turku University Hospital and University of Turku, Turku, Finland/Division of Clinical Neurosciences, Turku University Hospital and University of Turku, Turku, Finland.

Background:: Cerebrospinal fluid (CSF) levels of two soluble biomarkers, glial fibrillary acidic protein (GFAP) and neurofilament light chain (NfL), have been shown to associate with multiple sclerosis (MS) disease progression. Now, both biomarkers can be detected reliably in serum, and importantly, their serum levels correlate well with their CSF levels.

Objective:: To evaluate the usability of serum GFAP measurement as a biomarker of progressive disease and disease severity in MS. Read More

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http://dx.doi.org/10.1177/1352458518819380DOI Listing
December 2018
2 Reads

Jacques Jean Lhermitte and Lhermitte's sign.

Mult Scler 2018 Dec 20:1352458518820628. Epub 2018 Dec 20.

Department of Neurology, Brigham and Women's Hospital and Harvard Medical School, Boston, MA, USA/Department of Neurology, Massachusetts General Hospital and Harvard Medical School, Boston, MA, USA.

Jacques Jean Lhermitte, a forefather of modern clinical neurology, was a French neurologist conducting the majority of his research between 1908 and 1957. Although less well known than his contemporaries at the time, Lhermitte eventually was famously recognized for his eponymously named "Lhermitte's sign." Lhermitte's contributions to the field of neurology spanned that of monographic clinical descriptions of syndromes to exquisitely detailed descriptions of neuropathology, finally delving into the realm of modern neuropsychiatry in his later years. Read More

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http://dx.doi.org/10.1177/1352458518820628DOI Listing
December 2018
2 Reads

Dalfampridine benefits ambulation but not cognition in multiple sclerosis.

Mult Scler 2018 Dec 19:1352458518815795. Epub 2018 Dec 19.

Department of Neurology, Jacobs School of Medicine and Biomedical Sciences, University at Buffalo, The State University of New York, Buffalo, NY, USA.

Background:: Impaired cognition and ambulation are common in multiple sclerosis (MS). Dalfampridine is the first Food and Drug Administration (FDA)-approved medication to treat impaired ambulation in MS. Dalfampridine may benefit patients with cognitive impairment, given its effects on saltatory conduction and the association between cognitive and motor function. Read More

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http://journals.sagepub.com/doi/10.1177/1352458518815795
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http://dx.doi.org/10.1177/1352458518815795DOI Listing
December 2018
7 Reads

Slowly expanding/evolving lesions as a magnetic resonance imaging marker of chronic active multiple sclerosis lesions.

Mult Scler 2018 Dec 19:1352458518814117. Epub 2018 Dec 19.

NeuroRx Research, Montreal, QC, Canada/Department of Neurology and Neurosurgery, McGill University, Montreal, QC, Canada.

Background:: Chronic lesion activity driven by smoldering inflammation is a pathological hallmark of progressive forms of multiple sclerosis (MS).

Objective:: To develop a method for automatic detection of slowly expanding/evolving lesions (SELs) on conventional brain magnetic resonance imaging (MRI) and characterize such SELs in primary progressive MS (PPMS) and relapsing MS (RMS) populations.

Methods:: We defined SELs as contiguous regions of existing T2 lesions showing local expansion assessed by the Jacobian determinant of the deformation between reference and follow-up scans. Read More

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http://dx.doi.org/10.1177/1352458518814117DOI Listing
December 2018
3 Reads

Clinical commentary on 'Relapsing remitting multiple sclerosis in progressive external ophthalmoplegia: A report of two cases'.

Authors:
Lucy Matthews

Mult Scler 2018 Dec 17:1352458518816621. Epub 2018 Dec 17.

Nuffield Department of Clinical Neurosciences, University of Oxford, Oxford, UK.

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http://dx.doi.org/10.1177/1352458518816621DOI Listing
December 2018
3 Reads

Relapsing remitting multiple sclerosis in progressive external ophthalmoplegia: A report of two cases.

Mult Scler 2018 Dec 17:1352458518800794. Epub 2018 Dec 17.

Department of Neurology, Massachusetts General Hospital, Boston, MA, USA/ Harvard Medical School, Boston, MA, USA.

Evidence from genetic and pathologic studies suggests that mitochondrial dysfunction occurs in multiple sclerosis (MS). Furthermore, cases of MS have been reported in patients with mitochondrial disease. The phenotypic range of mitochondrial illness associating with MS is not yet well defined. Read More

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http://dx.doi.org/10.1177/1352458518800794DOI Listing
December 2018
2 Reads

Observatoire Français de la Sclérose en Plaques (OFSEP): A unique multimodal nationwide MS registry in France.

Mult Scler 2018 12 13:1352458518815602. Epub 2018 Dec 13.

Department of Neurology, CHU de Toulouse, Toulouse, France.

The care of multiple sclerosis (MS) in France is based on two complementary interlinked networks: MS expert centers in university hospitals and regional networks of neurologists. The routine use of European database for multiple sclerosis (EDMUS) in all those centers has paved the way for the constitution of a national registry, designated as Observatoire Français de la Sclérose En Plaques (OFSEP). It promotes a prospective, standardized, high-quality, and multimodal collection of data. Read More

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http://dx.doi.org/10.1177/1352458518815602DOI Listing
December 2018
2 Reads

Retinal degeneration is associated with brain volume reduction and prognosis in radiologically isolated syndrome.

Mult Scler 2018 Dec 11:1352458518817987. Epub 2018 Dec 11.

Department of Neurology, Hacettepe University, Ankara, Turkey.

Background:: The extent of neurodegeneration in the earliest stages of central nervous system (CNS) demyelination is not known. Optical coherence tomography (OCT) is a powerful tool to study neurodegeneration in demyelinating disorders.

Objectives:: To study neuroaxonal loss in the retina of individuals with radiologically isolated syndrome (RIS) and investigate whether OCT measurements are associated with brain volumetrics and clinical conversion to multiple sclerosis (MS). Read More

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http://dx.doi.org/10.1177/1352458518817987DOI Listing
December 2018
5 Reads

False hepatitis B and C viral serologies in patients with multiple sclerosis receiving high-dose biotin.

Mult Scler 2018 Dec 11:1352458518818294. Epub 2018 Dec 11.

4 Department of Neurology, Hôpital Pitié-Salpêtrière, AP-HP, Paris, France.

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http://dx.doi.org/10.1177/1352458518818294DOI Listing
December 2018
2 Reads

Optic nerve double inversion recovery hypersignal in patients with clinically isolated syndrome is associated with asymptomatic gadolinium-enhanced lesion.

Mult Scler 2018 Dec 3:1352458518815797. Epub 2018 Dec 3.

Department of Neurology, Roger Salengro Hospital, CHU Lille, University of Lille, Lille, France/Department of Neuroradiology, Roger Salengro Hospital, CHU Lille, University of Lille, Lille, France/UMR 1171, CHU Lille, University of Lille, Lille, France.

Background:: Optic nerve involvement is not considered in dissemination in space (DIS) or time (DIT) of multiple sclerosis (MS) lesions.

Objectives:: To evaluate frequency of optic nerve involvement using three-dimensional (3D)-double inversion recovery (DIR) sequence in clinically isolated syndrome (CIS) and to measure its relationship with DIS and DIT (2010 and 2017 McDonald criteria).

Methods:: From November 2013 to August 2016, 57 CIS patients underwent 3T-magnetic resonance imaging (3T-MRI) including 3D-DIR sequence and optical coherence tomography (OCT) at 3 months after CIS. Read More

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http://dx.doi.org/10.1177/1352458518815797DOI Listing
December 2018
3 Reads

Pregnancy and multiple sclerosis in the DMT era: A cohort study in Western Austria.

Mult Scler 2018 Dec 3:1352458518816614. Epub 2018 Dec 3.

Clinical Department of Neurology, Medical University of Innsbruck, Innsbruck, Austria.

Background:: Multiple sclerosis (MS) predominantly affects women of child-bearing potential. Pregnancy in MS is still a controversial issue lacking standardized treatment recommendations.

Objective:: To examine the reciprocal effects of pregnancy, MS, and disease-modifying treatment (DMT). Read More

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http://dx.doi.org/10.1177/1352458518816614DOI Listing
December 2018
3 Reads

Corrigendum.

Authors:

Mult Scler 2018 Dec 3:1352458518819093. Epub 2018 Dec 3.

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http://dx.doi.org/10.1177/1352458518819093DOI Listing
December 2018
2 Reads

Fatigue at enrollment predicts EDSS worsening in the New York State Multiple Sclerosis Consortium.

Mult Scler 2018 Dec 3:1352458518816619. Epub 2018 Dec 3.

New York State Multiple Sclerosis Consortium, Buffalo, NY, USA/Jacobs MS Center for Treatment and Research, Buffalo, NY, USA/ Department of Neurology, University at Buffalo, Buffalo, NY, USA.

Background:: Fatigue is one of the most common and distressing symptoms among persons with multiple sclerosis (pwMS).

Objective:: The aim of this study is to evaluate fatigue as a predictor for disease worsening among pwMS.

Methods:: In this retrospective cohort study of New York State MS Consortium (NYSMSC) registry, MS patients reporting moderate-to-severe fatigue at study enrollment ( n = 2714) were frequency matched to less-fatigued subjects ( n = 2714) on age, baseline Kurtzke Expanded Disability Status Scale (EDSS), disease duration, and MS phenotype. Read More

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http://dx.doi.org/10.1177/1352458518816619DOI Listing
December 2018
3 Reads
4.822 Impact Factor

Spinal cord and infratentorial lesions in radiologically isolated syndrome are associated with decreased retinal ganglion cell/inner plexiform layer thickness.

Mult Scler 2018 Dec 3:1352458518815597. Epub 2018 Dec 3.

Division of Neuroimmunology and Neurological Infections, Department of Neurology, Johns Hopkins University School of Medicine, Baltimore, MD, USA.

Background:: The role of retinal imaging with optical coherence tomography (OCT) in assessing individuals with radiologically isolated syndrome (RIS) remains largely unexplored.

Objective:: To assess retinal layer thicknesses in RIS and examine their associations with clinical features suggestive of increased risk for conversion to multiple sclerosis (MS).

Methods:: A total of 30 RIS subjects and 60 age- and sex-matched healthy controls (HC) underwent retinal imaging with spectral-domain OCT, followed by automated segmentation of retinal layers. Read More

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http://dx.doi.org/10.1177/1352458518815597DOI Listing
December 2018
2 Reads

Vitamin D deficiency is an etiological factor for MS - Yes.

Mult Scler 2018 Nov 30:1352458518809301. Epub 2018 Nov 30.

Centre for Clinical Epidemiology, Lady Davis Institute for Medical Research, Jewish General Hospital and Department of Human Genetics, McGill University, Montreal, QC, Canada; Departments of Epidemiology and Medicine, McGill University, Montreal, QC, Canada.

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http://dx.doi.org/10.1177/1352458518809301DOI Listing
November 2018
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Vitamin D deficiency is an etiological factor for MS - Commentary.

Mult Scler 2018 Nov 30:1352458518815605. Epub 2018 Nov 30.

Menzies Institute for Medical Research, University of Tasmania, Hobart, TAS, Australia.

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http://dx.doi.org/10.1177/1352458518815605DOI Listing
November 2018
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Vitamin D deficiency is an etiological factor for MS - No.

Mult Scler 2018 Nov 30:1352458518808469. Epub 2018 Nov 30.

National Centre for Epidemiology & Population Health, Research School of Population Health, Australian National University, Canberra, ACT, Australia.

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http://dx.doi.org/10.1177/1352458518808469DOI Listing
November 2018
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Therapeutic drug monitoring of natalizumab.

Authors:
Masami Tanaka

Mult Scler 2018 Nov 28:1352458518813657. Epub 2018 Nov 28.

1 Kyoto MS Center, Kyoto Min-Iren Chuo Hospital, Kyoto, Japan.

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http://dx.doi.org/10.1177/1352458518813657DOI Listing
November 2018
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Corrigendum.

Authors:

Mult Scler 2018 Nov 27:1352458518816270. Epub 2018 Nov 27.

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http://dx.doi.org/10.1177/1352458518816270DOI Listing
November 2018
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Longitudinal study of functional brain network reorganization in clinically isolated syndrome.

Mult Scler 2018 Nov 27:1352458518813108. Epub 2018 Nov 27.

University of Bordeaux, Bordeaux, France/Inserm U1215, Neurocentre Magendie, Bordeaux, France/CHU Pellegrin, CHU de Bordeaux, Bordeaux, France.

Background:: There is a lack of longitudinal studies exploring the topological organization of functional brain networks at the early stages of multiple sclerosis (MS).

Objective:: This study aims to assess potential brain functional reorganization at rest in patients with CIS (PwCIS) after 1 year of evolution and to characterize the dynamics of functional brain networks at the early stage of the disease.

Methods:: We prospectively included 41 PwCIS and 19 matched healthy controls (HCs). Read More

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http://dx.doi.org/10.1177/1352458518813108DOI Listing
November 2018
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Spinal cord lesions and atrophy in NMOSD with AQP4-IgG and MOG-IgG associated autoimmunity.

Mult Scler 2018 Nov 26:1352458518815596. Epub 2018 Nov 26.

NeuroCure Clinical Research Center, Charité - Universitätsmedizin Berlin, Berlin, Germany/Department of Neurology, University of California, Irvine, CA, USA.

Background:: Spinal cord (SC) affection is a hallmark symptom of neuromyelitis optica spectrum disorders (NMOSD). Patients with aquaporin-4 (AQP4-IgG+) or myelin oligodendrocyte glycoprotein (MOG-IgG+) antibody seropositivity show this overlapping clinical phenotype.

Objective:: Quantitative comparison of SC lesions and atrophy in AQP4-IgG+ and MOG-IgG+ NMOSD. Read More

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http://journals.sagepub.com/doi/10.1177/1352458518815596
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http://dx.doi.org/10.1177/1352458518815596DOI Listing
November 2018
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Smelling multiple sclerosis: Different qualities of olfactory function reflect either inflammatory activity or neurodegeneration.

Mult Scler 2018 Nov 22:1352458518814113. Epub 2018 Nov 22.

Department of Neurology, Medical University of Innsbruck, Innsbruck, Austria.

Background:: Peripapillary retinal nerve fiber layer (pRNFL) thickness and olfactory function are both emerging biomarkers in multiple sclerosis (MS). Impairment of odor identification and discrimination is an irreversible feature of more advanced MS suggested to be associated with neurodegeneration, while olfactory threshold is a transient feature of early, active MS possibly associated with short-term inflammatory disease activity.

Objective:: The aim of this study was to validate the association of olfactory (dys)function and parameters of MS disease course in a large cohort of MS patients and to correlate olfactory function with pRNFL thickness as a surrogate biomarker of neurodegeneration. Read More

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http://dx.doi.org/10.1177/1352458518814113DOI Listing
November 2018
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Necessity of technicians for computerized neuropsychological assessment devices in multiple sclerosis.

Mult Scler 2018 Nov 22:1352458518813287. Epub 2018 Nov 22.

Jacobs School of Medicine and Biomedical Sciences, University at Buffalo, The State University of New York, Buffalo, NY, USA.

Objective:: Determine the influence of technician supervision on computer-administered cognitive tests in multiple sclerosis (MS).

Methods:: Eighty MS patients underwent assessment using the CogState Brief Battery (CSBB) and the Cleveland Clinic Cognitive Battery (C3B). Each was administered twice, once with a technician guiding assessment, and once with technician-absent. Read More

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http://dx.doi.org/10.1177/1352458518813287DOI Listing
November 2018
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Resting-state MEG measurement of functional activation as a biomarker for cognitive decline in MS.

Mult Scler 2018 Nov 22:1352458518810260. Epub 2018 Nov 22.

Departments of Neurology and Clinical Neurophysiology, Magnetoencephalography Center Amsterdam UMC, Location VUmc, Amsterdam, The Netherlands.

Background:: Neurophysiological measures of brain function, such as magnetoencephalography (MEG), are widely used in clinical neurology and have strong relations with cognitive impairment and dementia but are still underdeveloped in multiple sclerosis (MS).

Objectives:: To demonstrate the value of clinically applicable MEG-measures in evaluating cognitive impairment in MS.

Methods:: In eyes-closed resting-state, MEG data of 83 MS patients and 34 healthy controls (HCs) peak frequencies and relative power of six canonical frequency bands for 78 cortical and 10 deep gray matter (DGM) areas were calculated. Read More

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http://dx.doi.org/10.1177/1352458518810260DOI Listing
November 2018
12 Reads