4,351 results match your criteria Multiple Sclerosis Journal[Journal]


Incidence, management, and outcomes of autoimmune nephropathies following alemtuzumab treatment in patients with multiple sclerosis.

Mult Scler 2019 Apr 15:1352458519841829. Epub 2019 Apr 15.

School of Medicine, University of Cambridge, Cambridge, UK.

Background: Autoimmune disorders including nephropathies have been reported more frequently in alemtuzumab-treated multiple sclerosis (MS) patients than in the general population.

Objective: Describe instances of autoimmune nephropathy in alemtuzumab-treated MS patients.

Methods: Cases were identified from safety monitoring within the alemtuzumab relapsing-remitting multiple sclerosis (RRMS) clinical development program (CDP) or post-marketing, or following off-label use. Read More

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http://dx.doi.org/10.1177/1352458519841829DOI Listing
April 2019
2 Reads

Evidence of diffuse cerebellar neuroinflammation in multiple sclerosis by C-PBR28 MR-PET.

Mult Scler 2019 Apr 11:1352458519843048. Epub 2019 Apr 11.

Athinoula A. Martinos Center for Biomedical Imaging, Department of Radiology, Massachusetts General Hospital, Boston, MA, USA/Harvard Medical School, Boston, MA, USA.

Background: Activated microglia, which can be detected in vivo by C-PBR28 positron emission tomography (PET), represent a main component of MS pathology in the brain. Their role in the cerebellum is still unexplored, although cerebellar involvement in MS is frequent and accounts for disability progression.

Objectives: We aimed at characterizing cerebellar neuroinflammation in MS patients compared to healthy subjects by combining C-PBR28 MRI-Positron Emission Tomography (MR-PET) with 7 Tesla (T) MRI and assessing its relationship with brain neuroinflammation and clinical outcome measures. Read More

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http://dx.doi.org/10.1177/1352458519843048DOI Listing
April 2019
2 Reads

Pregnancy outcomes in patients with multiple sclerosis treated with teriflunomide: Clinical study data and 5 years of post-marketing experience.

Mult Scler 2019 Apr 10:1352458519843055. Epub 2019 Apr 10.

Department of Pediatrics, Rady Children's Hospital and University of California San Diego, La Jolla, CA, USA.

Background: Teriflunomide is contraindicated in pregnancy. Some pregnancies have occurred despite guidance to use effective contraception.

Objectives: To report outcomes of pregnancies occurring in teriflunomide clinical trials and the post-marketing setting. Read More

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http://dx.doi.org/10.1177/1352458519843055DOI Listing
April 2019
1 Read

Challenging a concept: Pulsed treatment regimen-No risk of PML?

Mult Scler 2019 Apr 9:1352458519843232. Epub 2019 Apr 9.

Department of Neurology, Medical Faculty, Heinrich Heine University Düsseldorf, Düsseldorf, Germany.

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http://dx.doi.org/10.1177/1352458519843232DOI Listing

Immune profiling of a patient with alemtuzumab-associated progressive multifocal leukoencephalopathy.

Mult Scler 2019 Apr 9:1352458519832259. Epub 2019 Apr 9.

Centro di Ricerca Emato-oncologica AIL (CREA), Diagnostic Department, ASST Spedali Civili di Brescia, Brescia, Italy.

A 31-year-old woman affected by multiple sclerosis (MS) experienced generalized tonic-clonic seizures 2 months after the second alemtuzumab cycle. Positive JC virus (JCV)-DNA in cerebrospinal fluid (CSF) and lesion iconography at magnetic resonance imaging (MRI) were suggestive of progressive multifocal leukoencephalopathy (PML). After 1 month, during full-blown immune reconstitution inflammatory syndrome, JCV-DNA became negative and symptoms gradually improved. Read More

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http://dx.doi.org/10.1177/1352458519832259DOI Listing
April 2019
1 Read

Magnetisation transfer ratio abnormalities in primary and secondary progressive multiple sclerosis.

Mult Scler 2019 Apr 8:1352458519841810. Epub 2019 Apr 8.

NMR Research Unit, Queen Square Multiple Sclerosis Centre, Department of Neuroinflammation, UCL Institute of Neurology, Faculty of Brain Sciences, University College London, UK/National Institute for Health Research (NIHR) Biomedical Research Centre, University College London Hospitals (UCLH), London, UK.

Background: In relapse-onset multiple sclerosis (MS), tissue abnormality - as assessed with magnetisation transfer ratio (MTR) imaging - is greater in the outer cortical and inner periventricular layers. The cause of this remains unknown but meningeal inflammation has been implicated, particularly lymphoid follicles, which are seen in secondary progressive (SP) but not primary progressive (PP) MS. Cortical and periventricular MTR gradients might, therefore, differ in PPMS and SPMS if these follicles are responsible. Read More

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http://dx.doi.org/10.1177/1352458519841810DOI Listing
April 2019
1 Read

Are children with multiple sclerosis really "old" adults.

Authors:
Brenda Banwell

Mult Scler 2019 Apr 4:1352458519841505. Epub 2019 Apr 4.

Chief of Child Neurology, Children's Hospital of Philadelphia Professor of Neurology and Pediatrics, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA 19104, USA.

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http://dx.doi.org/10.1177/1352458519841505DOI Listing
April 2019
2 Reads

Childhood multiple sclerosis is associated with reduced brain volumes at first clinical presentation and brain growth failure.

Mult Scler 2019 Apr 4:1352458519829698. Epub 2019 Apr 4.

Department of Paediatric Neurology, Children's Hospital Datteln, Witten/Herdecke University, Datteln, Germany.

Background:: Paediatric multiple sclerosis (pedMS) patients at a single site were shown to have reduced brain volumes and failure of age-expected brain growth compared to healthy controls. However, the precise time of onset of brain volume loss remains unclear.

Objective:: To longitudinally study brain volumes in a multi-centre European cohort at first presentation and after 2 years. Read More

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http://dx.doi.org/10.1177/1352458519829698DOI Listing
April 2019
3 Reads

Letter to the editor regarding "Therapeutic drug monitoring of natalizumab".

Mult Scler 2019 Apr 3:1352458519837702. Epub 2019 Apr 3.

MS Center Dresden, Center of Clinical Neuroscience, Carl Gustav Carus University Hospital, University of Technology Dresden, Dresden, Germany.

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http://dx.doi.org/10.1177/1352458519837702DOI Listing
April 2019
1 Read

MOG-related disorders: A new cause of imaging-negative myelitis?

Mult Scler 2019 Apr 1:1352458519840746. Epub 2019 Apr 1.

Mellen Center for Multiple Sclerosis, Neurological Institute, Cleveland Clinic Foundation, Cleveland, OH, USA.

Knowledge on the clinical and radiological phenotype of myelin oligodendrocyte glycoprotein (MOG)-related disorders has been growing. We report the case of a patient who presented with subacute onset myelitis after an upper respiratory tract infection with normal cord imaging at onset and follow-up after 4 months (absence of lesions and atrophy), high-titer positive MOG-IgG, and a broad workup excluding other etiologies. The full clinical and radiological spectrum of MOG-related disorders is yet to be completely understood. Read More

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http://dx.doi.org/10.1177/1352458519840746DOI Listing
April 2019
1 Read

Relapsing lumbosacral myeloradiculitis: An unusual presentation of MOG antibody disease.

Mult Scler 2019 Apr 1:1352458519840747. Epub 2019 Apr 1.

Department of Neurology, Sree Chitra Tirunal Institute for Medical Sciences and Technology, Trivandrum, Thiruvananthapuram, India.

Myelin oligodendrocyte glycoprotein antibody (MOG-Ab) seropositivity is being increasingly reported in diverse demyelinating syndromes with monophasic and relapsing presentations. Conus myelitis is described as a typical feature of MOG-Ab seropositivity. However, the association with lumbosacral radiculitis in this disease is not well-recognized. Read More

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http://dx.doi.org/10.1177/1352458519840747DOI Listing
April 2019
2 Reads

Expanding the spectrum of MOG antibody disease.

Authors:
Michael Levy

Mult Scler 2019 Apr 1:1352458519841824. Epub 2019 Apr 1.

Department of Neurology, Massachusetts General Hospital, 15 Parkman Street, Boston, MA 02114-2696, USA.

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http://dx.doi.org/10.1177/1352458519841824DOI Listing
April 2019
1 Read

Longitudinal analysis of serum neurofilament light chain: A potential therapeutic monitoring biomarker for multiple sclerosis.

Mult Scler 2019 Mar 26:1352458519840757. Epub 2019 Mar 26.

Department of Neurology, Research Institute and Hospital of National Cancer Center, Goyang, Korea; Division of Clinical Research, Research Institute and Hospital of National Cancer Center, Goyang, Korea.

Objectives:: Serum neurofilament light chain (sNfL) has been proposed a potential biomarker in multiple sclerosis (MS) based on mainly cross-sectional observations in Western population. To clarify clinical implication of sNfL, we longitudinally analysed sNfL levels at multiple time points in Korean MS patients undergoing alemtuzumab therapy.

Methods:: Between 2016 and 2018, 144 sera from 17 MS patients treated with alemtuzumab at National Cancer Centre and 35 sera from 35 age- and gender-matched healthy controls (HCs) were collected for a longitudinal study with a mean 21-month follow-up. Read More

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http://dx.doi.org/10.1177/1352458519840757DOI Listing
March 2019
1 Read

MOG antibody-associated encephalomyelitis/encephalitis.

Mult Scler 2019 Mar 25:1352458519837705. Epub 2019 Mar 25.

Department of Neurology, Johns Hopkins University, Baltimore, MD, USA/Department of Neurology, Massachusetts General Hospital, Harvard Medical School, Boston, MA, USA.

Myelin oligodendrocyte glycoprotein (MOG) antibody disease is a rare autoimmune disorder with antibodies against the MOG predominantly involving the optic nerve and spinal cord leading to vision loss and paralysis. When MOG antibody disease involves the brain, the phenotype is similar to acute disseminated encephalomyelitis (ADEM). In this review, we discuss MOG-positive cases presenting with encephalitis, encephalopathy, or ADEM-like presentation based on recently published series. Read More

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http://dx.doi.org/10.1177/1352458519837705DOI Listing
March 2019
2 Reads

Functional neuroplasticity in response to cerebello-thalamic injury underpins the clinical presentation of tremor in multiple sclerosis.

Mult Scler 2019 Mar 25:1352458519837706. Epub 2019 Mar 25.

Department of Medicine and Radiology, University of Melbourne, Parkville, VIC, Australia/Florey Institute of Neuroscience and Mental Health, Parkville, VIC, Australia.

Background:: Tremor is present in almost half of multiple sclerosis (MS) patients. The lack of understanding of its pathophysiology is hampering progress in development of treatments.

Objectives:: To clarify the structural and functional brain changes associated with the clinical phenotype of upper limb tremor in people with MS. Read More

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http://dx.doi.org/10.1177/1352458519837706DOI Listing
March 2019
1 Read

Selective inversion recovery quantitative magnetization transfer imaging: Toward a 3 T clinical application in multiple sclerosis.

Mult Scler 2019 Mar 25:1352458519833018. Epub 2019 Mar 25.

Vanderbilt University Institute of Imaging Science, Department of Radiology and Radiological Sciences, Vanderbilt University Medical Center (VUMC), Nashville, TN, USA/ Department of Biomedical Engineering, Vanderbilt University, Nashville, TN, USA.

Background:: Assessing the degree of myelin injury in patients with multiple sclerosis (MS) is challenging due to the lack of magnetic resonance imaging (MRI) methods specific to myelin quantity. By measuring distinct tissue parameters from a two-pool model of the magnetization transfer (MT) effect, quantitative magnetization transfer (qMT) may yield these indices. However, due to long scan times, qMT has not been translated clinically. Read More

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http://dx.doi.org/10.1177/1352458519833018DOI Listing
March 2019
1 Read

Disease-modifying therapies should be stopped in NMOSD patients in remission - Yes.

Authors:
Eslam Shosha

Mult Scler 2019 Mar 22:1352458519829694. Epub 2019 Mar 22.

Department of Neurology, Prince Sultan Military Medical City, Ministry of Defense, Riyadh, Kingdom of Saudi Arabia.

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http://dx.doi.org/10.1177/1352458519829694DOI Listing

Disease-modifying therapies should be stopped in NMOSD patients in remission - Commentary.

Mult Scler 2019 Mar 22:1352458519837924. Epub 2019 Mar 22.

Department of Neurology, Mayo Clinic, Scottsdale, AZ, USA.

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http://dx.doi.org/10.1177/1352458519837924DOI Listing
March 2019
1 Read

Disease-modifying therapies should be stopped in NMOSD patients in remission - No.

Authors:
Dalia L Rotstein

Mult Scler 2019 Mar 22:1352458519832249. Epub 2019 Mar 22.

Multiple Sclerosis Clinic, St. Michael's Hospital, Toronto, ON, Canada.

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http://dx.doi.org/10.1177/1352458519832249DOI Listing
March 2019
2 Reads

Impairment of odor discrimination and identification is associated with disability progression and gray matter atrophy of the olfactory system in MS.

Mult Scler 2019 Mar 21:1352458519838205. Epub 2019 Mar 21.

Department of Neurology, Medical University of Innsbruck, Innsbruck, Austria/Neuroimaging Research Core Facility, Medical University of Innsbruck, Innsbruck, Austria.

Background:: Impairment of odor discrimination (D), identification (I), and threshold (T) are characteristic features of multiple sclerosis (MS).

Objective:: To identify patterns of gray matter concentration (GMC) associated with different qualities of olfactory function.

Methods:: Olfactory function (T and combined DI score) was measured by Sniffin' Sticks-Test over 2 years longitudinally, and T1-weighted 3-T magnetic resonance imaging (MRI) was performed in 37 MS patients and 18 matched healthy controls (HCs). Read More

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http://dx.doi.org/10.1177/1352458519838205DOI Listing
March 2019
3 Reads

Two-year dynamic functional network connectivity in clinically isolated syndrome.

Mult Scler 2019 Mar 19:1352458519837704. Epub 2019 Mar 19.

Neuroimaging Research Unit, Institute of Experimental Neurology, Division of Neuroscience, San Raffaele Scientific Institute, Vita-Salute San Raffaele University, Milan, Italy/Department of Neurology, Institute of Experimental Neurology, Division of Neuroscience, San Raffaele Scientific Institute, Vita-Salute San Raffaele University, Milan, Italy.

Background:: The features of functional network connectivity reorganization at the earliest stages of MS have not been investigated yet.

Objective:: To combine static and dynamic analysis of resting state (RS) functional connectivity (FC) to identify mechanisms of clinical dysfunction and recovery occurring in clinically isolated syndrome (CIS) patients.

Methods:: RS functional magnetic resonance imaging (fMRI) and clinical data were prospectively acquired from 50 CIS patients and 13 healthy controls (HC) at baseline, month 12 and month 24. Read More

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http://dx.doi.org/10.1177/1352458519837704DOI Listing
March 2019
3 Reads

Autonomic dysfunction in people with neuromyelitis optica spectrum disorders.

Mult Scler 2019 Mar 19:1352458519837703. Epub 2019 Mar 19.

School of Medicine, University of Zagreb, Zagreb, Croatia.

Aims:: To determine the difference in autonomic symptom burden measured with the Composite Autonomic System Score-31 (COMPASS-31) and presence of objective dysautonomia in people with neuromyelitis optica spectrum disorders (pwNMOSD) compared to people with multiple sclerosis (pwMS).

Design/methods:: Twenty pwNMOSD and 20 pwMS, matched for age, sex, and disease duration, were enrolled. All patients completed the COMPASS-31. Read More

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http://dx.doi.org/10.1177/1352458519837703DOI Listing
March 2019
3 Reads
4.822 Impact Factor

Reduced dynamics of functional connectivity and cognitive impairment in multiple sclerosis.

Mult Scler 2019 Mar 19:1352458519837707. Epub 2019 Mar 19.

Neuroimaging Research Unit, Institute of Experimental Neurology, Division of Neuroscience, San Raffaele Scientific Institute, Vita-Salute San Raffaele University, Milan, Italy/Department of Neurology, Institute of Experimental Neurology, Division of Neuroscience, San Raffaele Scientific Institute, Vita-Salute San Raffaele University, Milan, Italy.

Background:: In multiple sclerosis (MS), abnormalities of brain network dynamics and their relevance for cognitive impairment have never been investigated.

Objectives:: The aim of this study was to assess the dynamic resting state (RS) functional connectivity (FC) on 62 relapsing-remitting MS patients and 65 sex-matched healthy controls enrolled at 7 European sites.

Methods:: MS patients underwent clinical and cognitive evaluation. Read More

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http://dx.doi.org/10.1177/1352458519837707DOI Listing
March 2019
4 Reads

Post-mortem diagnosis of invasive pulmonary aspergillosis after alemtuzumab treatment for multiple sclerosis.

Mult Scler 2019 Mar 18:1352458518813110. Epub 2019 Mar 18.

Pathology Section, Department of Advanced Biomedical Sciences, University of Naples Federico II, Naples, Italy.

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http://dx.doi.org/10.1177/1352458518813110DOI Listing
March 2019
1 Read

Clinical commentary on 'Post-mortem diagnosis of invasive pulmonary aspergillosis after alemtuzumab treatment for multiple sclerosis'.

Authors:
Stephen W Reddel

Mult Scler 2019 Mar 18:1352458519835440. Epub 2019 Mar 18.

Department of Neurology, Concord Repatriation General Hospital, Sydney, NSW, Australia.

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http://dx.doi.org/10.1177/1352458519835440DOI Listing
March 2019
3 Reads

Axonal damage in spinal cord is associated with gray matter atrophy in sensorimotor cortex in experimental autoimmune encephalomyelitis.

Mult Scler 2019 Mar 7:1352458519830614. Epub 2019 Mar 7.

Ahmanson-Lovelace Brain Mapping Center, Department of Neurology, David Geffen School of Medicine, UCLA, Los Angeles, CA, USA/ UCLA Multiple Sclerosis Program, Department of Neurology, David Geffen School of Medicine, UCLA, Los Angeles, CA, USA.

Background:: Gray matter (GM) atrophy in brain is one of the best predictors of long-term disability in multiple sclerosis (MS), and recent findings have revealed that localized GM atrophy is associated with clinical disabilities. GM atrophy associated with each disability mapped to a distinct brain region, revealing a disability-specific atlas (DSA) of GM loss.

Objective:: To uncover the mechanisms underlying the development of localized GM atrophy. Read More

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http://dx.doi.org/10.1177/1352458519830614DOI Listing
March 2019
11 Reads

Predictive value of conventional MRI parameters in first spinal attacks of neuromyelitis optica spectrum disorder.

Mult Scler 2019 Mar 7:1352458519834857. Epub 2019 Mar 7.

Service de Neurologie, Hôpital Pierre Zobda-Quitman, Fort-de-France, French West Indies.

Background:: While spinal cord (SC) attacks of neuromyelitis optica spectrum disorder (NMOSD) are often devastating, signs predictive of their poor clinical outcome have been elusive until now, except for the delay in initiating plasma exchange (PE).

Objective:: We studied the correlation between conventional non-standardized magnetic resonance imaging (MRI) parameters, PE treatment, and clinical data obtained at nadir and recovery.

Methods:: Retrospective study of first SC attacks of NMOSD. Read More

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http://dx.doi.org/10.1177/1352458519834857DOI Listing

Robot-assisted gait training is not superior to intensive overground walking in multiple sclerosis with severe disability (the RAGTIME study): A randomized controlled trial.

Mult Scler 2019 Mar 4:1352458519833901. Epub 2019 Mar 4.

Department of Neuroscience and Rehabilitation, University Hospital of Ferrara, Ferrara, Italy/ Department of Biomedical and Surgical Specialties Sciences, University of Ferrara, Ferrara, Italy.

Background:: Rehabilitation may attenuate the impact on mobility of patients with progressive multiple sclerosis (MS) and severe gait disabilities.

Objective:: In this randomized controlled trial, we compared robot-assisted gait training (RAGT) with conventional therapy (CT) in terms of gait speed, mobility, balance, fatigue and quality of life (QoL).

Methods:: Seventy-two patients with MS (expanded disability status scale score 6. Read More

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http://dx.doi.org/10.1177/1352458519833901DOI Listing
March 2019
2 Reads

PET is necessary to make the next step forward in understanding MS pathophysiology - Commentary.

Mult Scler 2019 Feb 27:1352458519828299. Epub 2019 Feb 27.

Judith Jaffe Multiple Sclerosis Center, Department of Neurology, Weill Cornell Medicine, New York, NY, USA/Feil Family Brain and Mind Institute, Weill Cornell Medicine, New York, NY, USA/Department of Radiology, Weill Cornell Medicine, New York, NY, USA.

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http://journals.sagepub.com/doi/10.1177/1352458519828299
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http://dx.doi.org/10.1177/1352458519828299DOI Listing
February 2019
6 Reads

PET is necessary to make the next step forward in understanding MS pathophysiology - No.

Mult Scler 2019 Feb 27:1352458518820238. Epub 2019 Feb 27.

Neuroimaging Research Unit, Institute of Experimental Neurology, Division of Neuroscience, San Raffaele Scientific Institute, Vita-Salute San Raffaele University, Milan, Italy/Department of Neurology, Institute of Experimental Neurology, Division of Neuroscience, San Raffaele Scientific Institute, Vita-Salute San Raffaele University, Milan, Italy.

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http://dx.doi.org/10.1177/1352458518820238DOI Listing
February 2019

PET is necessary to make the next step forward in understanding MS pathophysiology - Yes.

Mult Scler 2019 Feb 27:1352458519828298. Epub 2019 Feb 27.

Sorbonne Universités, UPMC Paris 06, Institut du Cerveau et de la Moelle épinière, ICM, Hôpital de la Pitié Salpêtrière, Inserm UMR S 1127, CNRS UMR 7225, Paris, France/AP-HP, Hôpital Saint-Antoine, Paris, France.

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http://dx.doi.org/10.1177/1352458519828298DOI Listing
February 2019

Modelling the impact of multiple sclerosis on life expectancy, quality-adjusted life years and total lifetime costs: Evidence from Australia.

Mult Scler 2019 Feb 26:1352458519831213. Epub 2019 Feb 26.

Menzies Institute for Medical Research, University of Tasmania, Hobart, TAS, Australia.

Objectives: To quantify life expectancy (LE), quality-adjusted life years (QALYs) and total lifetime societal costs for a hypothetical cohort of Australians with multiple sclerosis (MS).

Methods: A 4-state Markov model simulated progression from no/mild to moderate and severe disability and death for a cohort of 35-year-old women over a lifetime horizon. Death risks were calculated from Australian life tables, adjusted by disability severity. Read More

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http://dx.doi.org/10.1177/1352458519831213DOI Listing
February 2019
1 Read

Insights into microbiome research 6: The role of consortia in studying the role of microbes in health and disease.

Mult Scler 2019 Mar;25(3):336-337

Department of Neurology, Weill Institute of Neuroscience, University of California, San Francisco, San Francisco, CA, USA.

Consortia are large, multidisciplinary research efforts that carry the power of numbers. In addition, they enable the sharing of protocols and strategies, ultimately resulting in credible, reproducible, and groundbreaking discoveries. Several consortia are currently investigating the role of bacteria in health and disease, including the International Multiple Sclerosis Microbiome Study (iMSMS), whose effort is dedicated to multiple sclerosis. Read More

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http://dx.doi.org/10.1177/1352458518811209DOI Listing
March 2019
1 Read

Clinical relevance of cortical network dynamics in early primary progressive MS.

Mult Scler 2019 Feb 25:1352458519831400. Epub 2019 Feb 25.

Queen Square MS Centre, UCL Institute of Neurology, University College London (UCL), London, UK/National Institute for Health Research, University College London Hospitals Biomedical Research Centre, London, UK.

Background:: Structural cortical networks (SCNs) reflect the covariance between the cortical thickness of different brain regions, which may share common functions and a common developmental evolution. SCNs appear abnormal in neurodegenerative conditions such as Alzheimer's and Parkinson's diseases, but have never been assessed in primary progressive multiple sclerosis (PPMS).

Objective:: The aim of this study was to test whether SCNs are abnormal in early PPMS and change over 5 years, and correlate with disability worsening. Read More

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http://dx.doi.org/10.1177/1352458519831400DOI Listing
February 2019

Insights into microbiome research 5: Mapping is first but function must come next.

Mult Scler 2019 Feb;25(2):193-195

Sergio E Baranzini Weill Institute of Neuroscience, Department of Neurology. University of California San Francisco, USA.

Several efforts identifying differential bacterial prevalence in the gut of multiple sclerosis (MS) patients have been reported and many more are underway. While these are critical first steps in determining the involvement of gut microbes in MS pathogenesis, functional assays (both in vitro and in vivo) are needed to explore the mechanisms underlying the observed changes and ultimately implementing interventional strategies to counter severity, progression or even reduce the chance that it develops in the first place. Read More

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http://dx.doi.org/10.1177/1352458518811203DOI Listing
February 2019

Insights into microbiome research 4: The computational analysis.

Mult Scler 2019 Jan;25(1):21-22

Department of Neurology, Weill Institute of Neuroscience, University of California, San Francisco, San Francisco, CA, USA.

The computational analysis of microbiome samples is a highly specialized task, requiring powerful hardware and deep know-how not only in informatics and statistics but also in ecology and taxonomy. Different approaches must be followed based on the sequencing method (16S or shotgun) and while these can provide partially overlapping information, they are conceptually distinct. Understanding their differences and similarities can be useful in the interpretation of the results of microbiome studies. Read More

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http://dx.doi.org/10.1177/1352458518811205DOI Listing
January 2019

MSJ 2019 - Editorial comment.

Mult Scler 2019 Jan;25(1):4-5

VU University Medical Centre, Amsterdam, The Netherlands.

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http://dx.doi.org/10.1177/1352458518819096DOI Listing
January 2019

Prevalence of multiple sclerosis in Sardinia: A systematic cross-sectional multi-source survey.

Mult Scler 2019 Feb 22:1352458519828600. Epub 2019 Feb 22.

Department of Clinical Governance, Sardinia Region Health Service, Cagliari, Italy.

Background: Partial surveys in sub-regions of Sardinia have suggested a high prevalence of multiple sclerosis (MS) on the island, relative to other Mediterranean populations. We assessed the island-wide prevalence of MS and its detailed distribution in Sardinia.

Methods: The study population consisted of 5677 MS patients, 1735 men and 3942 women, living in Sardinia. Read More

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http://journals.sagepub.com/doi/10.1177/1352458519828600
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http://dx.doi.org/10.1177/1352458519828600DOI Listing
February 2019
10 Reads

Breastfeeding and post-partum relapses in multiple sclerosis patients.

Mult Scler 2019 Feb 22:1352458519830588. Epub 2019 Feb 22.

Section of Neurosciences, Department of NEUROFARBA, University of Florence, Florence, Italy/IRCCS Fondazione Don Carlo Gnocchi, Florence, Italy.

While it is acknowledged that exclusive breastfeeding has well-established benefits for both infant/child and mother health, evidence on the relationships between breastfeeding and disease course in women with multiple sclerosis (MS) is still controversial. On one hand, in the post-partum period, a disease worsening is possible, particularly in women with more active MS. On the other hand, the use of disease modifying drugs is currently contraindicated during lactation. Read More

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http://dx.doi.org/10.1177/1352458519830588DOI Listing
February 2019

Immune thrombocytopenia in alemtuzumab-treated MS patients: Incidence, detection, and management.

Mult Scler 2019 Feb 20:1352458518816612. Epub 2019 Feb 20.

Department of Haematology, University Hospitals Leuven, Leuven, Belgium.

Background:: Alemtuzumab is a highly effective therapy for relapsing-remitting multiple sclerosis (RRMS), and immune thrombocytopenia (ITP) has been identified as a risk.

Objective:: To examine ITP incidence, treatment, and outcomes during the clinical development of alemtuzumab for RRMS and discuss postmarketing experience outside clinical trials.

Methods:: CAMMS223 and Comparison of Alemtuzumab and Rebif Efficacy in Multiple Sclerosis (CARE-MS) I and II investigated two annual courses of alemtuzumab 12 mg (or 24 mg in CAMMS223/CARE-MS II) versus subcutaneous interferon beta-1a three times per week. Read More

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http://dx.doi.org/10.1177/1352458518816612DOI Listing
February 2019

Iatrogenic CNS demyelination in the era of modern biologics.

Mult Scler 2019 Feb 15:1352458519828601. Epub 2019 Feb 15.

Case Western Reserve University School of Medicine, Cleveland, OH, USA; Multiple Sclerosis and Neuroimmunology Program, University Hospitals Cleveland Medical Center, Cleveland, OH, USA.

The number of reported cases of iatrogenic demyelination of the central nervous system (CNS) is on the rise. This is, in part, related to the recent expansion in the use of biologics. Review of literature from the past decade suggests that in addition to vaccines, tumor necrosis factor (TNF)-alpha inhibitors and checkpoint inhibitors are the most frequently cited inducers of central inflammation. Read More

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http://dx.doi.org/10.1177/1352458519828601DOI Listing
February 2019
8 Reads

Higher EBV response is associated with more severe gray matter and lesion pathology in relapsing multiple sclerosis patients: A case-controlled magnetization transfer ratio study.

Mult Scler 2019 Feb 13:1352458519828667. Epub 2019 Feb 13.

Buffalo Neuroimaging Analysis Center, Department of Neurology, Jacobs School of Medicine and Biomedical Sciences, University at Buffalo, The State University of New York, Buffalo, NY, USA/ Center for Biomedical Imaging, Clinical and Translational Science Institute, University at Buffalo, The State University of New York, Buffalo, NY, USA.

Background:: Epstein-Barr virus (EBV) infection has been associated with higher clinical activity and risk of multiple sclerosis (MS).

Objective:: To evaluate associations between EBV-specific humoral response and magnetization transfer ratio (MTR)-derived measure in MS patients and healthy controls (HCs).

Methods:: The study included 101 MS patients (69 relapsing-remitting multiple sclerosis (RRMS) and 32 secondary-progressive multiple sclerosis (SPMS)) and 41 HCs who underwent clinical, serological, and magnetic resonance imaging (MRI) investigations. Read More

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http://dx.doi.org/10.1177/1352458519828667DOI Listing
February 2019
2 Reads

MS progression is predominantly driven by age-related mechanisms - YES.

Authors:
Antonio Scalfari

Mult Scler 2019 Feb 12:1352458518820633. Epub 2019 Feb 12.

Divisions of Brain Sciences and Experimental Medicine, Department of Medicine, Centre for Neuroscience and Charing Cross Hospital, Imperial College London, London, UK.

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http://journals.sagepub.com/doi/10.1177/1352458518820633
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http://dx.doi.org/10.1177/1352458518820633DOI Listing
February 2019
5 Reads

MS progression is predominantly driven by age-related mechanisms - Commentary.

Mult Scler 2019 Feb 12:1352458518824767. Epub 2019 Feb 12.

Department of Neurology, Mayo Clinic, Rochester, MN, USA.

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http://dx.doi.org/10.1177/1352458518824767DOI Listing
February 2019

MS progression is predominantly driven by age-related mechanisms - NO.

Mult Scler 2019 Feb 12:1352458518819712. Epub 2019 Feb 12.

Mellen Center for Multiple Sclerosis, Neurological Institute, Cleveland Clinic, Cleveland, OH, USA.

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http://dx.doi.org/10.1177/1352458518819712DOI Listing
February 2019

Effect of disease-modifying therapies on subcortical gray matter atrophy in multiple sclerosis.

Mult Scler 2019 Feb 11:1352458519826364. Epub 2019 Feb 11.

Department of Neurology, Johns Hopkins University School of Medicine, Baltimore, MD, USA.

Background:: The effects of disease-modifying therapies (DMTs) on region-specific brain atrophy in multiple sclerosis (MS) are unclear.

Objective:: To determine the effects of higher versus lower efficacy DMTs on rates of brain substructure atrophy in MS.

Methods:: A non-randomized, observational cohort of people with MS followed with annual brain magnetic resonance imaging (MRI) was evaluated retrospectively. Read More

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http://dx.doi.org/10.1177/1352458519826364DOI Listing
February 2019
3 Reads

The efficacy of the modified Story Memory Technique in progressive MS.

Mult Scler 2019 Feb 11:1352458519826463. Epub 2019 Feb 11.

Neuropsychology and Neuroscience Laboratory, Kessler Foundation, West Orange, NJ, USA; Department of Physical Medicine and Rehabilitation, Rutgers New Jersey Medical School, Newark, NJ, USA; Department of Neurology, Rutgers New Jersey Medical School, Newark, NJ, USA.

Background:: Impairments in new learning and memory are common in individuals with multiple sclerosis (MS), negatively impacting everyday life, including occupational and social functioning.

Objective:: This study examined the efficacy of the modified Story Memory Technique (mSMT) in a progressive multiple sclerosis (PMS) sample through a double-blind, placebo-controlled, randomized clinical trial (RCT).

Methods:: Thirty (30) individuals with PMS, naïve to the mSMT, were randomized to the treatment or placebo control group. Read More

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http://dx.doi.org/10.1177/1352458519826463DOI Listing
February 2019
6 Reads

Lack of association between Toxocara canis and multiple sclerosis: A population-based case-control study.

Mult Scler 2019 Feb 11:1352458518825394. Epub 2019 Feb 11.

1 Department of Medical and Surgical Sciences and Advanced Technologies 'G.F. Ingrassia', Section of Neurosciences, University of Catania, Catania, Italy.

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http://dx.doi.org/10.1177/1352458518825394DOI Listing
February 2019
2 Reads

The spectrum of spinal cord lesions in a primate model of multiple sclerosis.

Mult Scler 2019 Feb 7:1352458518822408. Epub 2019 Feb 7.

Translational Neuroradiology Section, National Institute of Neurological Disorders and Stroke, National Institutes of Health, Bethesda, MD, USA.

Background:: Experimental autoimmune encephalomyelitis (EAE) in the common marmoset is a nonhuman primate model of multiple sclerosis (MS) that shares numerous clinical, radiological, and pathological features with MS. Among the clinical features are motor and sensory deficits that are highly suggestive of spinal cord (SC) damage.

Objective:: To characterize the extent and nature of SC damage in symptomatic marmosets with EAE using a combined magnetic resonance imaging (MRI) and histopathology approach. Read More

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http://dx.doi.org/10.1177/1352458518822408DOI Listing
February 2019

Oral D-Aspartate enhances synaptic plasticity reserve in progressive multiple sclerosis.

Mult Scler 2019 Feb 7:1352458519828294. Epub 2019 Feb 7.

Multiple Sclerosis Clinical & Research Center, Department of Systems Medicine, University of Rome Tor Vergata, Rome, Italy/ Unit of Neurology, IRCCS Neuromed, Pozzilli, Italy.

Background:: Synaptic plasticity reserve correlates with clinical recovery after a relapse in relapsing-remitting forms of multiple sclerosis (MS) and is significantly compromised in patients with progressive forms of MS. These findings suggest that progression of disability in MS is linked to reduced synaptic plasticity reserve. D-Aspartate, an endogenous aminoacid approved for the use in humans as a dietary supplement, enhances synaptic plasticity in mice. Read More

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http://dx.doi.org/10.1177/1352458519828294DOI Listing
February 2019
3 Reads
4.822 Impact Factor