1,247,177 results match your criteria Multiple Sclerosis


Diagnosis of A3 Pulley Injuries Using Ultrasound.

Sportverletz Sportschaden 2018 Dec 11;32(4):251-259. Epub 2018 Dec 11.

Department of Sportsmedicine, Department of Orthopedic and Trauma Surgery, Klinikum Bamberg, Bamberg, Germany.

Rationale And Objectives:  Pulley ruptures are the most common injuries in sport climbing. Ruptures of the A2 and A4 pulleys have been studied extensively, and ultrasound has proven to be a highly sensitive and specific tool for their diagnosis. However, the correct diagnosis of A3 pulley ruptures continues to be a challenge. Read More

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December 2018

Insulin Pump Therapy - Influence on Body Fat Redistribution, Skeletal Muscle Mass and Ghrelin, Leptin Changes in T1D Patients.

Obes Facts 2018 Dec 11;11(6):454-464. Epub 2018 Dec 11.

Clinic of Internal Medicine, Jessenius Faculty of Medicine in Martin (JFM CU), Comenius University in Bratislava, Bratislava, Slovakia.

Background: To report changes in body composition and biochemical parameters in patients with type 1 diabetes mellitus (T1D) after switching from multiple daily injection (MDI) to continuous subcutaneous insulin infusion (CSII).

Methods: 31 patients switched over from MDI to CSII. Body composition, biochemical parameters, glycaemic variability (GV) and level of physical activity were evaluated before and 6 months on CSII. Read More

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December 2018
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The Effectiveness of a Virtual Reality-Based Tai Chi Exercise on Cognitive and Physical Function in Older Adults with Cognitive Impairment.

Dement Geriatr Cogn Disord 2018 Dec 11;46(5-6):358-370. Epub 2018 Dec 11.

Department of Physical Therapy and Graduate Institute of Rehabilitation Science, College of Medicine, Chang Gung University, Taoyuan, Taiwan.

Background: Tai Chi (TC) is a Chinese mind-body exercise with proven physical and psychological benefits. A modified TC via virtual reality (VR) may be suitable for the elderly owing to the immediate guidance and feedback regarding movement accuracy. This study explored the cognitive and physical effects of a VR-based TC (VRTC) exercise program on older adults with cognitive impairment (CI). Read More

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December 2018

lncRNA SNHG8 Promotes the Tumorigenesis and Metastasis by Sponging miR-149-5p and Predicts Tumor Recurrence in Hepatocellular Carcinoma.

Cell Physiol Biochem 2018 7;51(5):2262-2274. Epub 2018 Dec 7.

Background/aims: Long noncoding RNAs (lncRNAs) are aberrantly expressed in multiple malignant tumors involved in tumor growth and metastasis. Accumulating data show that small nucleolar RNA host gene (SNHG) 1/12/20 plays a key role in the progression of hepatocellular carcinoma (HCC). However, the molecular mechanisms by which SNHG8 contributes to HCC remain elusive and merit exploration. Read More

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December 2018

Buccal Fat Pad: Report of 24 Cases and Literature Review of 1,635 Cases of Oral Defect Reconstruction.

ORL J Otorhinolaryngol Relat Spec 2018 Dec 11;81(1):24-35. Epub 2018 Dec 11.

Maxillo-Facial Surgery Unit, Neurosensorial Department, Azienda Ospedaliero-Universitaria Careggi, Florence, Italy.

Objective: The buccal fat pad (BFP) has been progressively introduced into clinical practice for oral defect reconstruction. This study describes our experience with this technique and compares indications in the literature and outcomes.

Methods: We prospectively enrolled 24 patients presenting oral surgical defects and treated between January 2012 and January 2015 at our institution. Read More

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December 2018

Progression of Hearing Loss in the Aging Population: Repeated Auditory Measurements in the Rotterdam Study.

Audiol Neurootol 2018 Dec 11;23(5):290-297. Epub 2018 Dec 11.

Department of Otorhinolaryngology, Head and Neck Surgery, Erasmus University Medical Center, Rotterdam, The Netherlands.

We quantified changes in the auditory acuity of 675 aging adults (mean age 71.1 years, 52.0% female, mean follow-up 4. Read More

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December 2018

Biology of Nodal Spread in Colon Cancer: Insights from Molecular and Genetic Studies.

Eur Surg Res 2018 Dec 11;59(5-6):361-370. Epub 2018 Dec 11.

Division of Colorectal Surgery, Department of Surgery, University of Michigan, Ann Arbor, Michigan,

Colorectal cancer (CRC) lymph node metastases are common but their genetics and the mechanism whereby these metastases occur are not well understood. Here we present recent data regarding genetic heterogeneity in primary CRCs and their metastasis. In addition, we explain the different potential models describing the mechanisms of metastasis and the data supporting them. Read More

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December 2018

In Vivo Assessment of Combined Effects of Glibenclamide and Losartan in Diabetic Rats.

Med Princ Pract 2018 Dec 10. Epub 2018 Dec 10.

Objective: Diabetic complications involve multiple pathological pathways, including hyperglycemia-induced oxidative stress and inflammation. Combination therapy is usually employed to improve treatment outcomes and to lower potential adverse effects. In this study, we evaluated the effects of antidiabetic and antihypertensive agents, glibenclamide (GLI) and losartan (LT), on diabetes-associated metabolic changes in rats. Read More

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December 2018

Plan-view transmission electron microscopy specimen preparation for atomic layer materials using a focused ion beam approach.

Ultramicroscopy 2018 Dec 5;197:95-99. Epub 2018 Dec 5.

Department of Materials Science and Engineering, National Taiwan University, Taipei 10617, Taiwan; Center of Atomic Initiative for New Materials, National Taiwan University, Taipei 10617, Taiwan. Electronic address:

Using the focused ion beam (FIB) to prepare plan-view transmission electron microscopy (TEM) specimens is beneficial for obtaining structural information of two-dimensional atomic layer materials, such as graphene and molybdenum disulfide (MoS) nanosheets supported on substrates. The scanning electron microscopy (SEM) image in a dual-beam FIB-SEM can accurately locate an area of interest for specimen preparation. Besides, FIB specimen preparation avoids damages and hydrocarbon contamination that are usually produced in other preparation methods, in which chemical etching and polymer adhesion layers are used. Read More

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December 2018

Prospective study of clinical, neurophysiological and urodynamic findings in multiple scleosis patients undergoing percutaneous transluminal venous angioplasty.

Clin Neurophysiol 2018 Nov 26;130(1):138-144. Epub 2018 Nov 26.

Department of Medicine, Surgery and Neuroscience, Unit of Neurology and Clinical Neurophysiology, University of Siena, Italy. Electronic address:

Objective: Verify whether Percutaneous Transluminal Angioplasty (PTA) may affect neural conduction properties in Multiple Sclerosis (MS) patients, thereby modifying patients' disability, with prospective neurophysiological, urodynamic, clinical and subjective well-being evaluations.

Methods: In 55 out of 72 consecutively screened MS patients, the following procedures were carried out before (T0), at 2-6 months (T1) and at 6-15 months (T2) after a diagnostic phlebography, eventually followed by the PTA intervention if chronic cerebrospinal venous insufficiency (CCSVI) was diagnosed: clinical/objective evaluation (Expanded Disability Status Scale, EDSS), ratings of subjective well-being, evaluation of urodynamic functions and multimodal EPs (visual, acoustic, upper and lower limbs somatosensory and motor evoked potentials).

Results: The number of dropouts was relatively high, and a complete set of neurophysiological and clinical data remained available for 37 patients (19 for urological investigations). Read More

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November 2018

From cognitive and clinical substrates to functional profiles: Disentangling heterogeneity in schizophrenia.

Psychiatry Res 2018 Dec 6;271:446-453. Epub 2018 Dec 6.

Department of Clinical Neurosciences, IRCCS San Raffaele Scientific Institute, Via Stamira d'Ancona 20, 20127 Milan, Italy; School of Medicine, Vita-Salute San Raffaele University, Milan, Italy.

The relationship between neurocognition and functioning among patients with schizophrenia is well documented. However, integrating neuropsychological, clinical and psychopathological data to better investigate functional outcome still constitutes a challenge. Artificial neural network-based modeling might help to better capture clinical heterogeneity by analyzing the non-linear relationships among multiple variables. Read More

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December 2018

Impact of disinfectant on bacterial antibiotic resistance transfer between biofilm and tap water in a simulated distribution network.

Environ Pollut 2018 Nov 24;246:131-140. Epub 2018 Nov 24.

College of Environmental Science and Engineering, Tongji University, Shanghai, 200092, China.

Bacterial antibiotic resistance (BAR) is profoundly important to human health, but the environmental reservoirs of resistance determinants are poorly understood. BAR of biofilm and tap water were analyzed by using a water distribution simulator where different doses of chlorine and chloramine were used in this study. The results revealed that the disinfectants (≥2 mg/L) suppressed antibiotic resistant bacteria (ARB) in tap water and biofilms, while disinfected water and biofilms had a high relative abundance of ARB. Read More

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November 2018

QSPR estimation models of normal boiling point and relative liquid density of pure hydrocarbons using MLR and MLP-ANN methods.

J Mol Graph Model 2018 Nov 29;87:109-120. Epub 2018 Nov 29.

Laboratory of Biomaterials and Transport Phenomena (LBMPT), University of Médéa, Médéa, 26000, Algeria.

This work aimed to predict the normal boiling point temperature (Tb) and relative liquid density (d20) of petroleum fractions and pure hydrocarbons, through a multi-layer perceptron artificial neural network (MLP-ANN) based on the molecular descriptors. A set of 223 and 222 diverse data points for Tb and d20 were respectively used to build two quantitative structure property relationships-artificial neural network (QSPR-ANN) models. For each model, the total database was divided respectively into two subsets: 80% for the training set and 20% for the test set. Read More

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November 2018

Natural products: Potential therapeutic agents in multiple sclerosis.

Int Immunopharmacol 2018 Dec 8;67:87-97. Epub 2018 Dec 8.

Murad Research Center for Modernized Chinese Medicine, Institute of Interdisciplinary Integrative Medicine Research, Shanghai University of Traditional Chinese Medicine, Shanghai 201203, China; Key Laboratory of Smart Drug Delivery, Fudan University, Ministry of Education, Shanghai 201203, China. Electronic address:

Multiple sclerosis is an autoimmune neurodegenerative disease, which usually caused by inflammation, demyelination, and axonal injury. The currently available medications for multiple sclerosis do not directly promote myelin sheath repair. Therefore, many researches have attempted to achieve better therapeutic effects through promoting remyelination. Read More

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December 2018

An LC-MS/MS method for quantification of abiraterone, its active metabolites D(4)-abiraterone (D4A) and 5α-abiraterone, and their inactive glucuronide derivatives.

J Chromatogr B Analyt Technol Biomed Life Sci 2018 Dec 4;1104:249-255. Epub 2018 Dec 4.

Pharmacogenomics Laboratory, Centre Hospitalier Universitaire (CHU) de Québec, - Université Laval Research Center and Faculty of Pharmacy, Laval University, Québec city, QC, Canada; Canada Research Chair in Pharmacogenomics, Canada. Electronic address:

Abiraterone acetate (AA) is a prodrug of abiraterone, a selective and potent steroidal cytochrome P450 17alpha- hydroxylase-17,20-lyase (CYP17A1) blocking androgen synthesis in the treatment of advanced prostate cancer. Abiraterone (Abi) is metabolized to D(4)-abiraterone (D4A) directly blocking CYP17A1 and other steroidogenic enzymes and antagonizing the androgen receptor (AR). D4A is converted by 5α-reductase to 3-keto-5α-abiraterone (5α-Abi), an AR agonist. Read More

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December 2018

Action research improves services for child sexual abuse in one Caribbean nation: An example of good practice.

Child Abuse Negl 2018 Dec 8;88:225-234. Epub 2018 Dec 8.

Institute of Gender and Development Studies, The University of the West Indies, St. Augustine, Trinidad and Tobago.

Background: Child sexual abuse (CSA) is a multi-dimensional problem. The search for best practice must consider the complexities surrounding CSA and its management in any particular society.

Objective: Data previously gathered from service providers on CSA service provision in Trinidad and Tobago identified key deficient issues in policy and practice. Read More

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December 2018

Comparative physiological and proteomic analyses of the chloroplasts in halophyte Sesuvium portulacastrum under differential salt conditions.

J Plant Physiol 2018 Nov 16;232:141-150. Epub 2018 Nov 16.

Institute of Tropical Biosciences and Biotechnology, Chinese Academy of Tropical Agricultural Sciences, Haikou Hainan 571101, China; College of Life Sciences, Key Laboratory for Ecology of Tropical Islands, Ministry of Education, Hainan Normal University, Haikou, Hainan 571158, China. Electronic address:

Sesuvium portulacastrum, an important mangrove-associated true halophyte belongs to the family Aizoaceae, has excellent salt tolerance. Chloroplasts are the most sensitive organelles involved in the response to salinity. However, the regulation mechanism of chloroplasts of S. Read More

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November 2018

Engineering of multiple modular pathways for high-yield production of 5-aminolevulinic acid in Escherichia coli.

Bioresour Technol 2018 Dec 3;274:353-360. Epub 2018 Dec 3.

The Key Laboratory of Industrial Biotechnology, Ministry of Education, School of Biotechnology, Jiangnan University, Wuxi 214122, China; The Key Laboratory of Carbohydrate Chemistry and Biotechnology, Ministry of Education, Jiangnan University, Wuxi 214122, China. Electronic address:

5-aminolevulinic acid (ALA), an important precursor of tetrapyrroles, has various applications in medicine and agriculture fields. Several methods have been adopted to enhance ALA synthesis in our previous studies. In this study, systematic metabolic engineering strategies were implemented to further improve ALA production in Escherichia coli. Read More

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December 2018

Influence of patient positioning on reported clinical outcomes after greater occipital nerve block for treatment of headache: Results from prospective single-centre, non-randomised, proof-of-concept study.

Clin Neurol Neurosurg 2018 Dec 3;176:73-77. Epub 2018 Dec 3.

Science & Innovation Manager, R&D Department, Cumbria Partnership NHS Foundation Trust, Carlisle, CA1 3SX, UK. Electronic address:

Objective: Greater occipital nerve (GON) block is a treatment option applied for a variety of primary headache disorders. Although a patient's body position is known to have an impact on the effect of local anaesthetics, this has not before been investigated for patients undergoing GON block. Therefore, the clinical effectiveness of either a sitting or supine position was assessed. Read More

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December 2018

Mid-calf skeletal muscle density and its associations with physical activity, bone health and incident 12-month falls in older adults: The Healthy Ageing Initiative.

Bone 2018 Dec 8. Epub 2018 Dec 8.

Department of Community Medicine and Rehabilitation, Geriatric Medicine, Umeå University, Umeå, Sweden.

Background: Lower skeletal muscle density, indicating greater infiltration of adipose tissue into muscles, is associated with higher fracture risk in older adults. We aimed to determine whether mid-calf muscle density is associated with falls risk and bone health in community-dwelling older adults.

Methods: 2214 community-dwelling men and women who participated in the Healthy Ageing Initiative (Sweden) study at age 70 were included in this analysis. Read More

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December 2018
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The Role of Salvage Second Autologous Hematopoietic Cell Transplantation in Relapsed Multiple Myeloma.

Biol Blood Marrow Transplant 2018 Dec 8. Epub 2018 Dec 8.

Loyola University Medical Center, Internal Medicine, 2160 S 1(st) Ave, IL, Maywood, Illinois 60153, United States.

Multiple myeloma (MM) is a malignant disorder of plasma cells primarily affecting elderly patients and is the second most commonly diagnosed hematological neoplasm. With the recent influx of effective new agents available including proteasome inhibitors, immunomodulators, targeted monoclonal antibodies, and now chimeric antigen receptor t-cell therapy (CAR-T), the treatment landscape is evolving rapidly. While the role of consolidative autologous stem cell transplantation (ASCT) in first remission is well established, in the relapsed setting following up front ASCT, the role of a second ASCT (SAT) following reinduction is less clear and understudied. Read More

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December 2018

Postoperative antiplatelet therapy in the treatment of complex basilar apex aneurysms implementing Hunterian ligation and extracranial-to-intracranial bypass: review of the literature with an illustrative case report.

World Neurosurg 2018 Dec 8. Epub 2018 Dec 8.

Neurorestoration Center, Keck School of Medicine, University of Southern California, Los Angeles, CA, USA; Department of Neurological Surgery, Keck School of Medicine, University of Southern California, Los Angeles, CA, USA. Electronic address:

Large, broad-based basilar artery (BA) apex aneurysms involving multiple arterial origins are complex lesions commonly not amenable to direct clipping or endovascular management. BA proximal (Hunterian) occlusion with extracranial-to-intracranial bypass is a supported strategy if one or both posterior communicating arteries are small. Hunterian ligation risks sudden aneurysm thrombosis and thromboembolism in the perforator rich BA apex. Read More

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December 2018

A systematic review of measures estimates adherence and persistence to multiple medications.

J Clin Epidemiol 2018 Dec 8. Epub 2018 Dec 8.

University of Groningen, University Medical Center Groningen, Department of Clinical Pharmacy and Pharmacology, The Netherlands.

Objectives: We reviewed measures used to estimate adherence and persistence to multiple cardiometabolic medications from prescription data, particularly for blood pressure-lowering, lipid-lowering, and/or glucose-lowering medication, and give guidance on which measures to choose.

Study Design And Setting: A literature search of Medline, Embase, and PsycINFO databases was conducted to identify studies assessing medication adherence and/or persistence for patients using multiple cardiometabolic medications. Two reviewers performed the study selection process independently. Read More

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December 2018

Allicin enhances antimicrobial activity of macrophages during Mycobacterium tuberculosis infection.

J Ethnopharmacol 2018 Dec 8. Epub 2018 Dec 8.

Special Centre for Molecular Medicine, Jawaharlal Nehru University, New Delhi, India. Electronic address:

Ethnopharmacological Relevance: The emergence of drug-resistant Mycobacterium tuberculosis (M.tb) strains has severely hampered global efforts towards tuberculosis (TB) eradication. The internationally accepted therapy "Directly Observed Treatment Short-course (DOTS)" is lengthy, and incorporates risks for the generation of drug-resistant M. Read More

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December 2018

Distinct roles of GluA2-lacking AMPA receptor expression in dopamine D1 or D2 receptor neurons in animal behavior.

Neuroscience 2018 Dec 8. Epub 2018 Dec 8.

Department of Biomedical Sciences, Colorado State University, Fort Collins, CO, 80523, United States. Electronic address:

Dopaminergic signaling in the central nervous system regulates several aspects of animal behavior. In the dopaminergic circuits, there are two classes of neurons that can be differentiated by their expression of dopamine receptors, D1 or D2 receptors (D1Rs or D2Rs). Notably, Ca-permeable GluA2-lacking glutamate AMPA receptors (CP-AMPARs) are important for gating synaptic plasticity and gene expression in neurons, and their expression particularly in the striatum affects various forms of animal behavior. Read More

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December 2018

Targeting PKCδ as a Therapeutic Strategy against Heterogeneous Mechanisms of EGFR Inhibitor Resistance in EGFR-Mutant Lung Cancer.

Cancer Cell 2018 Dec;34(6):954-969.e4

Department of Molecular and Cellular Oncology, The University of Texas MD Anderson Cancer Center, Houston, TX 77030, USA; Center for Molecular Medicine and Graduate Institute of Biomedical Sciences, China Medical University, Taichung 404, Taiwan; Department of Biotechnology, Asia University, Taichung 413, Taiwan. Electronic address:

Multiple mechanisms of resistance to epidermal growth factor receptor (EGFR) tyrosine kinase inhibitors (TKIs) have been identified in EGFR-mutant non-small cell lung cancer (NSCLC); however, recurrent resistance to EGFR TKIs due to the heterogeneous mechanisms underlying resistance within a single patient remains a major challenge in the clinic. Here, we report a role of nuclear protein kinase Cδ (PKCδ) as a common axis across multiple known TKI-resistance mechanisms. Specifically, we demonstrate that TKI-inactivated EGFR dimerizes with other membrane receptors implicated in TKI resistance to promote PKCδ nuclear translocation. Read More

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December 2018

Simple, rapid and inexpensive typing of common HLA class I alleles for immunological studies.

J Immunol Methods 2018 Dec 8. Epub 2018 Dec 8.

University of Queensland Diamantina Institute, The University of Queensland, Translational Research Institute, Woolloongabba, Queensland, Australia. Electronic address:

Current HLA-typing methods are typically designed to provide exquisitely-detailed identification of multiple HLA-alleles to satisfy the requirements for organ and bone marrow transplantation or genetic studies. Many human immunological studies, on the other hand, focus around only a small number of HLA alleles that are abundant or of relevance to specific diseases. Consequently, for such studies, many HLA typing approaches are not cost-effective and are potentially complicated, slow and not easily performed in-house. Read More

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December 2018

Quality Improvement Training in a Variety of Cancer Care Delivery Settings: Experiences From a Comprehensive Cancer Center, an Academic Medical Center, and Community Practices.

J Oncol Pract 2018 Dec;14(12):e815-e822

Beth Israel Deaconess Medical Center; Dana-Farber Cancer Institute; Partners HealthCare; and Massachusetts General Hospital, Boston, MA.

Purpose:: Training clinical and supportive staff in quality improvement (QI) theory and use of QI tools has the potential to improve oncology care delivery. We report our combined experience of providing training to oncologists in a variety of local settings and assess the effect of the training on individual participants and for institutions.

Methods:: Multidisciplinary oncology teams at a comprehensive cancer center, an academic medical center, and community practices were led through experiential QI training that spanned several months. Read More

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December 2018

GAGA protein is required for multiple aspects of Drosophila oogenesis and female fertility.

Genesis 2018 Dec 10:e23269. Epub 2018 Dec 10.

Institute of Cytology and Genetics of the Siberian Branch of the Russian Academy of Sciences, Novosibirsk, Russia.

Investigation of Drosophila oogenesis provides the opportunity to understand conservative genetic mechanisms underlying fertile female gamete development. In this work, we showed that the Drosophila DNA-binding protein GAGA factor (GAF) had a multifunctional role in oogenesis and it is involved in the regulation of this process genetic program. We studied the influence on Drosophila oogenesis of a number of mutations in the 5' region of the Trl gene that encodes GAF. Read More

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December 2018

The digitally replicated denture technique: A case report.

J Esthet Restor Dent 2018 Dec 11. Epub 2018 Dec 11.

ROE Dental Laboratory, Independence, Ohio.

Objective: Conventional complete denture protocols require several patient appointments with multiple laboratory procedures. There are multiple workflows incorporating digital technology that can expedite the process, whereas increasing predictability. The proposed digitally replicated denture technique (DRDT) demonstrates a predictable workflow for fabricating complete dentures for patients with existing dentures. Read More

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December 2018

Brain MRI Lesions are Related to Bowel Incontinence in Multiple Sclerosis.

J Neuroimaging 2018 Dec 11. Epub 2018 Dec 11.

Department of Neurology, University Hospital Erlangen, Friedrich-Alexander-Universität Erlangen-Nürnberg, Erlangen, Germany.

Background And Purpose: Bowel incontinence in multiple sclerosis might be associated with specific lesion sites. This study intended to determine associations between bowel incontinence and cerebral multiple sclerosis lesions using a voxel-wise lesion symptom mapping analysis.

Methods: We conducted a retrospective study of multiple sclerosis patients with self-reported bowel incontinence and matched controls. Read More

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December 2018
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Depth of invasion as a predictor of nodal disease and survival in patients with oral tongue squamous cell carcinoma.

Head Neck 2018 Dec 7. Epub 2018 Dec 7.

Department of Head and Neck Surgery, Division of Surgery, The University of Texas MD Anderson Cancer Center, Houston, Texas.

Background: Depth of invasion (DOI) in oral cavity cancer is important in determining prognosis. This study aims to determine optimal cut-points of DOI for detection of occult disease and survival.

Methods: A retrospective cohort study was completed of previously untreated early stage lateral oral tongue cancer. Read More

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December 2018

Comparison of vitamin D metabolites in wild and captive baboons.

Am J Primatol 2018 Dec;80(12):e22935

Department of Neuroscience, Washington University School of Medicine, Saint Louis, Missouri.

Vitamin D adequacy is essential for multiple physiologic processes. With limited exposure to sunlight for vitamin D synthesis, captive primates are supplemented with vitamin D (cholecalciferol). Vitamin D metabolite data from wild primates living indigenously could suggest optimum levels. Read More

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December 2018
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Genotype and phenotype correlations for SHANK3 de novo mutations in neurodevelopmental disorders.

Am J Med Genet A 2018 Dec 9. Epub 2018 Dec 9.

Center for Medical Genetics & Hunan Provincial Key Laboratory of Medical Genetics, School of Life Sciences, Central South University, Changsha, Hunan, China.

SHANK3 has been identified as the causative gene of 22q13.3 microdeletion syndrome phenotype. De novo mutations (DNMs) of SHANK3 were subsequently identified in patients with several neurodevelopmental disorders, including autism spectrum disorders (ASDs), schizophrenia (SCZ), a Rett syndrome-like phenotype, and intellectual disability (ID). Read More

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December 2018
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Multiple receptors converge on H2-Q10 to regulate NK & γδT cell development.

Immunol Cell Biol 2018 Dec 9. Epub 2018 Dec 9.

Department of Immunology and Pathology, Central Clinical School, Monash University, Melbourne, Australia.

Class Ib MHC are an extended family of molecules which demonstrate tissue-specific expression and presentation of monomorphic antigens. These characteristics tend to imbue class Ib MHC with unique functions. H2-Q10 is potentially one such molecule in that it is overexpressed in the liver but its immunological function is not known. Read More

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December 2018

Towards the molecular deciphering of Pomacea canaliculata immunity: first proteomic analysis of circulating hemocytes.

Proteomics 2018 Dec 10:e1800314. Epub 2018 Dec 10.

Department of Life Sciences, 41125, Modena, Italy.

Pomacea canaliculata is a freshwater snail with interesting biological features that include invasiveness, human parasite hosting and adult regeneration. Its immune system may represent the target for strategies aimed at controlling the spread of the snail population and its hosting of the human parasite Angiostrongylus cantonensis. Moreover, immune functions likely have a role in the snail's ability to wound heal and regenerate. Read More

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December 2018

Clinical and echocardiography predictors of response to inhaled nitric oxide in hypoxic preterm neonates.

J Paediatr Child Health 2018 Dec 8. Epub 2018 Dec 8.

Department of Pediatrics, University of Toronto, Toronto, Ontario, Canada.

Aim: To evaluate the clinical and echocardiography modulators of treatment response in hypoxemic preterm infants exposed to inhaled nitric oxide (iNO).

Methods: In this multicentre retrospective study, clinical parameters, including oxygenation, ventilation and haemodynamics, were collected for preterm infants <36 weeks gestation before and 2 h after initiation of iNO for acute hypoxemia. Comprehensive echocardiography, performed near the time iNO initiation, was analysed by experts blind to the clinical course. Read More

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December 2018

Scavager: a versatile postsearch validation algorithm for shotgun proteomics based on gradient boosting.

Proteomics 2018 Dec 8:e1800280. Epub 2018 Dec 8.

Institute for Energy Problems of Chemical Physics, Russian Academy of Sciences, 119334, Moscow, Russia.

Shotgun proteomics workflows for database protein identification typically include a combination of search engines and postsearch validation software based mostly on machine learning algorithms. Here we present a new postsearch validation tool called Scavager employing CatBoost, an open-source gradient boosting library, which shows improved efficiency compared with the other popular algorithms, such as Percolator, PeptideProphet, and Q-ranker. The comparison was done using multiple data sets and search engines, including MSGF+, MSFragger, X!Tandem, Comet, and recently introduced IdentiPy. Read More

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December 2018

Virus genotyping by massive parallel amplicon sequencing: adenovirus and enterovirus in the Norwegian MIDIA study.

J Med Virol 2018 Dec 10. Epub 2018 Dec 10.

Division of Mental and Physical Health, Department of Chronic Diseases and Ageing, Norwegian Institute of Public Health, Oslo, Norway.

Objectives: Direct genotyping of adenovirus or enterovirus from clinical material using polymerase chain reaction (PCR) followed by Sanger sequencing is often difficult due to the presence of multiple virus types in a sample, or due to varying efficacy of PCR amplifying the capsid gene on the background of foreign nucleic acids. Here we present a simple protocol for virus genotyping using massive parallel amplicon sequencing.

Methods: The protocol utilized a set of 16 tailed degenerate primers flanking the seventh hypervariable region of the adenovirus hexon gene and 9 tailed degenerate primers targeted to the proximal portion of the enterovirus VP1 gene. Read More

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December 2018

Early Endovascular Thrombectomy for Large Vessel Ischemic Stroke Reduces Disability at 90 Days.

Acad Emerg Med 2018 Dec 8. Epub 2018 Dec 8.

Department of Neurology, University of Minnesota, Minneapolis, Minnesota.

Anterior circulation large vessel occlusion (LVO) of the internal carotid or middle cerebral artery is one of the most devastating ischemic stroke subtypes. Prior to 2015, evidence supporting endovascular thrombectomy for acute ischemic stroke was limited. This was due to multiple factors, including low recanalization rates with previous generation thrombectomy devices, inadequate neuroimaging inclusion criteria (patients enrolled in trials lacked target LVO and/or had large pre-existing core infarcts), and selection bias-patients considered most likely to benefit from thrombectomy underwent the procedure outside of clinical trials. Read More

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December 2018

Effects of chronic diseases on health-related quality of life and self-rated health among three adult age groups.

Nurs Health Sci 2018 Dec 10. Epub 2018 Dec 10.

Health Services and Outcomes Research, National Healthcare Group, Singapore.

Little is known about whether there is any difference in associations of chronic diseases with health-related quality of life and self-rated health across age groups. The purpose of the present study was to examine the associations of one specific and multiple chronic diseases with health-related quality of life and self-rated health (measured using the 5-level EQ-5D version) in three age groups: young (21-44 years), middle-aged (45-64 years), and older adults (≥65 years). Secondary data analysis of 1932 participants in the Population Health Index Survey was performed. Read More

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December 2018

Exploratory structural equation modeling for event-related potential data-An all-in-one approach?

Psychophysiology 2018 Dec 7:e13303. Epub 2018 Dec 7.

Institute of Psychology, University of Leipzig, Leipzig, Germany.

ERP data are characterized by high dimensionality and a mixture of constituting signals and are thus challenging for researchers to analyze. To address these challenges, exploratory factor analysis (EFA) has been used to provide estimates of the unobserved factors and to use these estimates for further statistical analyses (e.g. Read More

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December 2018

Initiation and interruption in intravenous bisphosphonate therapy among patients with multiple myeloma in the United States.

Cancer Med 2018 Dec 8. Epub 2018 Dec 8.

Massachusetts General Hospital, Harvard Medical School, Boston, Massachusetts.

Background: Prior to 2018, intravenous bisphosphonates (IV BPs) were the only therapies recommended to prevent skeletal-related events for patients diagnosed with multiple myeloma (MM). We examined patterns of IV BP initiation and interruption among patients with newly diagnosed MM (NDMM) in the United States.

Methods: Electronic health records linked to administrative health insurance claims were used to identify adults with NDMM between 1 January 2011 and 30 April 2016. Read More

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December 2018

Functional Characterization of LIKE HETEROCHROMATIN PROTEIN 1 in the moss Physcomitrella patens: its conserved protein interactions in land plants.

Plant J 2018 Dec 7. Epub 2018 Dec 7.

University School of Biotechnology, Guru Gobind Singh Indraprastha University, Sector 16C, Dwarka, New, Delhi-110078, India.

In flowering plants LIKE HETEROCHROMATIN PROTEIN 1 (LHP1)/TERMINAL FLOWER 2 (TFL2) is known to interact with polycomb group (PcG) and non-PcG proteins and control developmental programs. LHP1/TFL2 is an ancient protein and has been characterized in the early-divergent plant Physcomitrella patens. However, interacting partners of PpLHP1 other than the chromomethylase PpCMT have not been identified to date. Read More

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December 2018

Medication dosing for heart failure with reduced ejection fraction - opportunities and challenges.

Eur J Heart Fail 2018 Dec 10. Epub 2018 Dec 10.

Department of Medicine, University of Mississippi Medical Center, Jackson, MS, USA.

Multiple drug classes have shown incremental benefits in heart failure with reduced ejection fraction. Most of these trials were designed to achieve specific doses of the investigational agent. Clinical practice guidelines recommend using the same target dosing of therapies, as tolerated. Read More

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December 2018

Trends and state variations in out-of-hospital births in the United States, 2004-2017.

Birth 2018 Dec 10. Epub 2018 Dec 10.

Community Health Sciences Department, Boston University School of Public Health, Boston, Massachusetts.

Background: Out-of-hospital births have been increasing in the United States, although past studies have found wide variations between states. Our purpose was to examine trends in out-of-hospital births, the risk profile of these births, and state differences in women's access to these births.

Methods: National birth certificate data from 2004 to 2017 were analyzed. Read More

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December 2018

Role of ADHD in the Co-occurrence between Heavy Alcohol Use and Depression Trajectories in Adulthood.

Alcohol Clin Exp Res 2018 Dec 10. Epub 2018 Dec 10.

University of Pittsburgh, Medical Center Department of Psychiatry.

Background: Attention-Deficit/Hyperactivity Disorder (ADHD) is associated with greater heavy alcohol use and depressive symptoms in adulthood. Yet, few studies have investigated whether childhood ADHD predicts an increased association between heavy drinking and depression in adulthood when this co-occurrence becomes more common. We examined associations among heavy alcohol use and depression longitudinally from ages 21 to 29 and whether these associations differed for those with or without childhood ADHD, as well as for those with or without persistent ADHD in adulthood. Read More

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December 2018

Multiple chemical sensitivity syndrome is not caused by contact allergy.

Contact Dermatitis 2018 Dec 10. Epub 2018 Dec 10.

Department of Cutaneous Allergy, St John's Institute of Dermatology, Guy's & St Thomas' NHS Foundation Trust, London, UK.

There is a lack of published data on the role of patch testing in patients with so-called multiple chemical sensitivity (MCS), also known as idiopathic environmental intolerances (IEI). This disputed chronic condition is characterised by symptoms that the affected person attributes to low-level exposures to commonly used chemicals. Symptoms are typically vague and non-specific and may include fatigue, headaches, nausea, dizziness, a sensation of skin burning or pain. Read More

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December 2018
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The Effect of Ceramic Type and Background Color on Shade Reproducibility of All-Ceramic Restorations.

J Prosthodont 2018 Dec 7. Epub 2018 Dec 7.

Advanced Specialty Education Program in Prosthodontics, Loma Linda University, School of Dentistry, Loma Linda, CA.

Purpose: To investigate the effects of background color on shade reproduction using CAD/CAM zirconia and lithium disilicate ceramics.

Materials And Methods: A plastic tooth was prepared for an all-ceramic crown, scanned, and tooth shaped light background dies were manufactured. Full contour crowns were milled from translucent zirconia (ZT) and low translucency lithium disilicates (E [LT]). Read More

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December 2018
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