89,074 results match your criteria Multiple Sclerosis


Adaptive Engagement and Support Model for People with Chronic Health Conditions: Using Combined Content Analysis to Assess Online Health Communities.

J Med Internet Res 2020 Jun 3. Epub 2020 Jun 3.

Health Union, LLC, 1217 Sansom Street2nd Floor, Philadelphia, US.

Background: With the pervasiveness of social media, online health communities (OHC) are an important tool for facilitating information sharing and support among people with chronic health conditions. Importantly, OHCs offer insight into conversations about the lived experiences of people with particular health conditions. What is less known is what aspects of OHCs are important to maintain safe and productive conversations that support health. Read More

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http://dx.doi.org/10.2196/17338DOI Listing

Cladribine modifies functional properties of microglia.

Clin Exp Immunol 2020 Jun 3. Epub 2020 Jun 3.

Department of Neurology, Odense University Hospital, Odense, Denmark.

Background: Cladribine (CdA), an oral prodrug approved for the treatment of relapsing multiple sclerosis, selectively depletes lymphocytes. CdA passes the blood-brain barrier suggesting a potential effect on CNS resident cells.

Objective: We examined, if CdA modifies the phenotype and function of naïve and activated primary mouse microglia, when applied in the concentrations 0. Read More

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http://dx.doi.org/10.1111/cei.13473DOI Listing

Dickkopf-related protein 3 is a novel biomarker for chronic GVHD after allogeneic hematopoietic cell transplantation.

Blood Adv 2020 Jun;4(11):2409-2417

Clinical Research Division, Fred Hutchinson Cancer Research Center, Seattle, WA.

To identify plasma biomarkers associated with fibrotic mechanisms of chronic graft-versus-host disease (GVHD), we used multiplex mass spectrometry with pooled samples for biomarker discovery in comparing proteomic profiles between patients with newly diagnosed sclerotic chronic GVHD (n = 21), those with newly diagnosed nonsclerotic chronic GVHD (n = 33), and those without chronic GVHD (n = 20). Immunoassay was used to measure protein concentrations of individual discovery samples and 186 independent verification samples. The discovery mass spectrometry analysis identified 2 candidate proteins with at least 1. Read More

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http://dx.doi.org/10.1182/bloodadvances.2020001485DOI Listing

Adapted physical activity in community-dwelling adults with neurological disorders: design and outcomes of a fitness-center based program.

Disabil Rehabil 2020 Jun 3:1-6. Epub 2020 Jun 3.

CRF Les Trois Soleils, Médecine Physique et de Réadaptation, Unité de Rééducation Neurologique, Boissise-Le-Roi, France.

To describe and evaluate an adapted physical activity-based program (APA-program) designed for community-dwelling patients with neurological diseases in local fitness centers. The APA-program consisted of individual and group activities supervised by an adapted physical activity (APA) instructor twice a week for 6 months. Clinical evaluations before and after the APA-program included strength tests on gym machines, the six-minute walk test (6MWT), the single-leg stance test, and the Short Form-36 (SF-36). Read More

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http://dx.doi.org/10.1080/09638288.2020.1771439DOI Listing

Spiritual health in women with multiple sclerosis and its association with self-esteem.

J Educ Health Promot 2020 31;9:64. Epub 2020 Mar 31.

Nursing and Midwifery Care Research Center, Isfahan University of Medical Sciences, Isfahan, Iran.

Introduction: Spiritual health is one of the four dimensions of health in humans, and the others are physical, psychological, and social dimensions. This dimension is essential to increase the adaptation to the disease. Therefore, this study was aimed to determine spiritual health in women with multiple sclerosis (MS) and its association with self-esteem. Read More

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http://dx.doi.org/10.4103/jehp.jehp_144_19DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7255585PMC

Inversion recovery zero echo time (IR-ZTE) imaging for direct myelin detection in human brain: a feasibility study.

Quant Imaging Med Surg 2020 May;10(5):895-906

Department of Radiology, University of California San Diego, San Diego, CA, USA.

Background: Myelin alteration is closely associated with neurological diseases such as multiple sclerosis (MS). Unfortunately, due to myelin's extremely short T2* (~0.3 ms or shorter at 3T), it cannot be directly imaged with conventional MR imaging techniques. Read More

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http://dx.doi.org/10.21037/qims.2020.04.13DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7242298PMC

Psycho-neuro-endocrino-immunologic issues in multiple sclerosis: a critical review of clinical and therapeutic implications.

Hormones (Athens) 2020 Jun 1. Epub 2020 Jun 1.

University Research Institute of Maternal and Child Health and Precision Medicine, Medical School, National and Kapodistrian University of Athens, Athens, Greece.

Multiple sclerosis (MS) is a multifactorial, chronic, immune-mediated, and neurodegenerative disease, having a well-known hypothalamic-pituitary-adrenal (HPA) axis dysfunction. Several hormones have a great impact in the immune dysregulation, psychology, and cognitive status of patients with MS, as also in the fertility and response to treatment. In this comprehensive review, as an introduction, we mention basic data concerning MS: epidemiology, genetics, immunogenetics, epigenetics, pathophysiology, and neuroimmunology. Read More

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http://dx.doi.org/10.1007/s42000-020-00197-8DOI Listing

SF-6D health state utilities for lifestyle, sociodemographic and clinical characteristics of a large international cohort of people with multiple sclerosis.

Qual Life Res 2020 Jun 1. Epub 2020 Jun 1.

Menzies Institute for Medical Research, University of Tasmania, Hobart, Tasmania, Australia.

Background: While many studies have examined the impacts of multiple sclerosis (MS) on health-related quality of life (HRQoL), none have used the SF-6D multi-attribute utility instrument in a large international cohort (> 2000 subjects) of people with MS.

Objectives: To derive SF-6D health state utilities (HSUs) for participants of the HOLISM (Health Outcomes and Lifestyle In a Sample of people with Multiple Sclerosis) international cohort and to describe the distribution and determinants thereof.

Methods: HSUs were generated using the SF-6D for participants with sufficient SF-36 data [n = 2185/2466 (88. Read More

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http://dx.doi.org/10.1007/s11136-020-02505-6DOI Listing

Siponimod (Mayzent) Downregulates RhoA and Cell Surface Expression of the S1P1 and CX3CR1 Receptors in Mouse RAW 264.7 Macrophages.

Arch Immunol Ther Exp (Warsz) 2020 Jun 1;68(3):19. Epub 2020 Jun 1.

The Houston Methodist Research Institute, Houston, TX, USA.

The Siponimod (Mayzent) is a newly developed drug, similar to Fingolimod (FTY720) but with fewer side effects, approved by the Food and Drug Administration for the treatment of multiple sclerosis (MS). The therapeutic effect of siponimod and FTY720 in MS relies on their inhibitory effect on the sphingosine 1-phosphate (S1P) signaling. These drugs bind to the S1P receptors and block the CCL2 chemokine pathway that is responsible for the exit of the immune cells from the lymphoid organs, and circulation, thus preventing immune cell-dependent injury to the nervous system. Read More

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http://dx.doi.org/10.1007/s00005-020-00584-4DOI Listing

Commentary: The Multiple Sclerosis Controversy: Is It Escalation or Induction High Efficacy?

Authors:
Patricia K Coyle

Neurotherapeutics 2020 Jun 2. Epub 2020 Jun 2.

Department of Neurology, Stony Brook University Medical Center, Stony Brook, NY, 11794, USA.

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http://dx.doi.org/10.1007/s13311-020-00869-8DOI Listing

Listeria infection after treatment with alemtuzumab: a case report and literature review. Would antibiotic prophylaxis be considered?

Infez Med 2020 Jun;28(2):258-262

Department of Medical and Surgical Sciences, Infectious and Tropical Diseases Unit, "Magna Graecia" University, Catanzaro, Italy.

Few cases of complicated infections with Listeria monocytogenes (LM) have been reported to date in patients with multiple sclerosis (MS) treated with alemtuzumab. Primary prevention strategies may be suggested in such patients to avoid infections. However, these may be ineffective because patients may already be carriers of LM. Read More

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A confused patient with deranged liver function tests.

Pract Neurol 2020 Jun 2. Epub 2020 Jun 2.

Department of Neurology, Royal Preston Hospital, Lancashire Teaching Hospitals NHF Foundation Trust, Preston PR2 9HT, UK.

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http://dx.doi.org/10.1136/practneurol-2020-002594DOI Listing

A G protein-biased S1P agonist, SAR247799, protects endothelial cells without affecting lymphocyte numbers.

Sci Signal 2020 Jun 2;13(634). Epub 2020 Jun 2.

Diabetes and Cardiovascular Research, Sanofi US Services, 55 Corporate Drive, Bridgewater, NJ 08807, USA.

Endothelial dysfunction is a hallmark of tissue injury and is believed to initiate the development of vascular diseases. Sphingosine-1 phosphate receptor-1 (S1P) plays fundamental physiological roles in endothelial function and lymphocyte homing. Currently available clinical molecules that target this receptor are desensitizing and are essentially S1P functional antagonists that cause lymphopenia. Read More

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http://dx.doi.org/10.1126/scisignal.aax8050DOI Listing

Association of explanatory histological findings and urinary protein and serum creatinine levels at renal biopsy in lupus nephritis: a cross-sectional study.

BMC Nephrol 2020 Jun 1;21(1):208. Epub 2020 Jun 1.

Department of Nephrology, Rheumatology, Endocrinology and Metabolism, Okayama University Graduate School of Medicine, Dentistry and Pharmaceutical Sciences, 2-5-1 Shikata-cho, Kitaku, Okayama, 700-8558, Japan.

Background: The aim of the present study was to evaluate the association between the histology of active and chronic lesions and urinary protein and serum creatinine (SCr) levels, as common clinical endpoints in clinical trials for lupus nephritis (LN).

Methods: In total, 119 patients diagnosed with LN class III, IV, and V, as defined by the International Society of Nephrology/Renal Pathology Society, between 1990 and 2015, were enrolled in the present study. Multiple regression analysis was performed to explore semi-quantitative histological variables associated with urinary protein and SCr levels. Read More

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http://dx.doi.org/10.1186/s12882-020-01868-9DOI Listing

Recent Advances in Antigen-Specific Immunotherapies for the Treatment of Multiple Sclerosis.

Brain Sci 2020 May 29;10(6). Epub 2020 May 29.

Chemical Process and Energy Resources Institute, Centre for Research and Technology Hellas, P.O. Box 60361, 57001 Thessaloniki, Greece.

Multiple sclerosis (MS) is an autoimmune disease of the central nervous system and is considered to be the leading non-traumatic cause of neurological disability in young adults. Current treatments for MS comprise long-term immunosuppressant drugs and disease-modifying therapies (DMTs) designed to alter its progress with the enhanced risk of severe side effects. The Holy Grail for the treatment of MS is to specifically suppress the disease while at the same time allow the immune system to be functionally active against infectious diseases and malignancy. Read More

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http://dx.doi.org/10.3390/brainsci10060333DOI Listing

Efficacy and safety of rituximab in multiple sclerosis: Experience from a developing country.

Mult Scler Relat Disord 2020 May 24;43:102210. Epub 2020 May 24.

Department of Neurology, St. John's Medical College Hospital, Sarjapura Road, Bengaluru, Karnataka,560034, India.

Background: Rituximab is increasingly being used in treatment of multiple Sclerosis (MS) in our centers due to its easy availability, efficacy and favorable side effect profile. Here we describe experience with rituximab over a period of 4 years from three MS centers from south India.

Methods: The data of MS patients who were treated with rituximab in three MS centers at Bangalore, India, from December 2015 to December 2019 were collected and evaluated with respect to relapse rate, EDSS score and adverse events. Read More

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http://dx.doi.org/10.1016/j.msard.2020.102210DOI Listing

Effect of hippotherapy on walking performance and gait parameters in people with multiple sclerosis.

Mult Scler Relat Disord 2020 May 26;43:102203. Epub 2020 May 26.

Laboratory of Human Motion Analysis, Faculty of Physical Education, University of Brasilia, Brasilia, DF, Brazil.

Background: Walking dysfunction is one of the most common symptoms of multiple sclerosis (MS).

Objective: To evaluate the effects of an 8-week hippotherapy intervention on walking performance and spatiotemporal gait parameters in people with relapsing-remitting MS; and to examine whether the effects of hippotherapy on walking performance are mediated by changes in spatiotemporal gait parameters.

Methods: Participants were assigned into a hippotherapy intervention group (n = 17) or a control group (n = 16). Read More

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http://dx.doi.org/10.1016/j.msard.2020.102203DOI Listing

FTY720 reactivates cryptococcal granulomas in mice through S1P receptor 3 on macrophages.

J Clin Invest 2020 Jun 2. Epub 2020 Jun 2.

Department of Microbiology and Immunology, Stony Brook University, Stony Brook, United States of America.

FTY720 (Gilenya, Novartis), is a treatment for relapsing remitting multiple sclerosis (MS). It is an analog of sphingosine-1-phosphate (S1P) and targets S1P receptors 1,3,4, and 5. Recent reports indicate an association between long term exposure to FTY720 and cases of cryptococcal infection. Read More

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http://dx.doi.org/10.1172/JCI136068DOI Listing

Diagnostic uncertainty during the transition to secondary progressive multiple sclerosis: Multicenter study in Argentina.

Mult Scler 2020 Jun 2:1352458520924586. Epub 2020 Jun 2.

Centro de Esclerosis Múltiple de Buenos Aires, Buenos Aires, Argentina.

Background: A period of diagnostic uncertainty often characterizes the clinical transition from relapsing to secondary progressive multiple sclerosis (SPMS).

Objective: The aim of this study was to describe the length of time required to reclassify relapsing-remitting MS (RRMS) patients who have clinically transitioned to SPMS (diagnosis uncertainty).

Methods: This is a retrospective multicenter cohort study conducted in Argentina, identifying in every center all patients with diagnosis of MS who transitioned from RRMS to SPMS during the follow-up. Read More

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http://dx.doi.org/10.1177/1352458520924586DOI Listing

Novel Automated Method for the Detection of White Matter Hyperintensities in Brain Multispectral MR Images.

Curr Med Imaging 2020 ;16(5):469-478

Department of Radiology, Taichung Veterans General Hospital, Taichung, Taiwan.

Background: According to the Standards for Reporting Vascular Changes on Neuroimaging, White Matter Hyperintensities (WMHs) are cerebral white matter lesions that are characterized by abnormal tissues of variable sizes and appear hyperintense in T2-weighted Magnetic Resonance (MR) measurements without cavitation (i.e., their tissue signals differ from those of Cerebrospinal Fluid or CSF). Read More

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http://dx.doi.org/10.2174/1573405614666180801112844DOI Listing
January 2020

Clinical Data for the Use of Cannabis-Based Treatments: A Comprehensive Review of the Literature.

Ann Pharmacother 2020 Jun 2:1060028020930189. Epub 2020 Jun 2.

Intermountain Healthcare, Taylorsville, UT, USA.

To compile and synthesize the available literature describing medical cannabis use across various disease states. PubMed, EBSCO, and Google Scholar searches were conducted using MeSH and/or keywords. Studies were included if they described the use of cannabis-based products and medications in the treatment of a predefined list of disease states in humans and were published in English. Read More

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http://dx.doi.org/10.1177/1060028020930189DOI Listing

Comparing the Effectiveness of Computer-Based, Manual-based, and Combined Cognitive Rehabilitation on Cognitive Functions in Relapsing-Remitting Multiple Sclerosis Patients.

Basic Clin Neurosci 2020 Jan-Feb;11(1):99-110. Epub 2020 Jan 1.

Department of Clinical Psychology, Arak University of Medical Sciences, Arak, Iran.

Introduction: This study aimed to compare the effectiveness of computer-based, manual-based, and combined cognitive rehabilitation to improve cognitive functions among patients with Relapsing-Remitting Multiple Sclerosis (RRMS).

Methods: This was a quasi-experimental study with a pre-test-post-test, and a 2-month follow-up, as well as a control group design. Sixty female patients with RRMS were selected by convenience sampling technique. Read More

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http://dx.doi.org/10.32598/bcn.9.10.430DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7253816PMC
January 2020

What is the role of axonal ion channels in multiple sclerosis?

Neurology 2020 Jun 1. Epub 2020 Jun 1.

From the Department of Neurology (J.C., M.M.), Fleni, Buenos Aires, Argentina; and Department of Neurology (E.E.B.), Mayo Clinic, Rochester, MN.

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http://dx.doi.org/10.1212/WNL.0000000000009754DOI Listing

Perceptions, experiences, and understandings of cluster headache among GPs and neurologists: a qualitative study.

Br J Gen Pract 2020 Jun 1. Epub 2020 Jun 1.

School of Medicine, Keele University, Keele, UK.

Background: Cluster headache is a severe primary headache with a similar prevalence to that of multiple sclerosis. Cluster headache is characterised by unilateral trigeminal distribution of pain, ipsilateral cranial autonomic features, and a tendency to circadian and circannual periodicity.

Aim: To explore the perceptions, experiences, and understandings of cluster headache among GPs and neurologists. Read More

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http://dx.doi.org/10.3399/bjgp20X710417DOI Listing

Swimming Exercise Ameliorates Symptoms of MOG-Induced Experimental Autoimmune Encephalomyelitis by Inhibiting Inflammation and Demyelination in Rats.

Int Neurourol J 2020 May 31;24(Suppl 1):S39-47. Epub 2020 May 31.

Department of Physiology, College of Medicine, Kyung Hee University, Seoul, Korea.

Purpose: Multiple sclerosis is an autoimmune disease that affects the central nerve system, resulting in cumulative loss of motor function. Multiple sclerosis is induced through multiple mechanisms and is caused by inflammation and demyelination. This study aims to evaluate the neuroprotective effect of swimming exercise in experimental autoimmune encephalomyelitis (EAE) rats, an animal model of multiple sclerosis. Read More

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http://dx.doi.org/10.5213/inj.2040156.078DOI Listing

Effects of aquatic exercises on postural control and hand function in Multiple Sclerosis: Halliwick versus Aquatic Plyometric Exercises: a randomised trial.

J Musculoskelet Neuronal Interact 2020 Jun;20(2):249-255

Private Clinic, Izmir, Turkey.

Objectives: Postural control and hand dexterity are significantly impaired in people with multiple sclerosis (pwMS). Aquatic interventions may have additional benefits in the treatment of pwMS. The purpose of this study is to compare the effects of two different aquatic exercises on postural control and hand function. Read More

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Hypoglossal Nerve: Anatomy, Anatomical Variations Comorbidities and Clinical Significance.

J Long Term Eff Med Implants 2019 ;29(3):197-203

Department of Anatomy and Surgical Anatomy, Medical School of National and Kapodistrian University of Athens, Athens, Greece.

We review the anatomical variations of the hypoglossal nerve and their surgical and clinical significance, and we report multiple diseases that affect function of the nerve leading to paresis, either unilateral or bilateral. The hypoglossal nerve is the 12th cranial nerve, and knowledge of the detailed anatomy and relationship with critical structures is of paramount importance in neurosurgery, head and neck surgery, and vascular surgery. Numerous studies have depicted conventional landmarks in the cervical part of the hypoglossal nerve, but their findings have not been consistent reliable. Read More

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http://dx.doi.org/10.1615/JLongTermEffMedImplants.2020033230DOI Listing
January 2019

Validity of the McDonald criteria in predicting second events in multiple sclerosis.

Mult Scler Relat Disord 2020 May 25;43:102223. Epub 2020 May 25.

Department of Epidemiology and Biostatistics, School of Public Health, Jilin University, Changchun, Jilin 130021, China. Electronic address:

Background: The McDonald criteria are designed for predicting the second event in multiple sclerosis. With several revisions made to the McDonald criteria, the criteria get much easier to use, but what about the diagnostic validity? This research is conducted for evaluating the diagnostic validity of the McDonald criteria in multiple sclerosis.

Methods: Pubmed, Web of Science, Cochrane Library were systematically searched with keywords of "Multiple sclerosis" and "McDonald criteria" from, January 1, 2010 to 27, February 2020. Read More

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http://dx.doi.org/10.1016/j.msard.2020.102223DOI Listing

Neuropsychological assessments and psychotherapeutic services in Veterans with multiple sclerosis: Rates of utilization and their associations with socio-demographics and clinical characteristics using Veterans Health Administration-based data.

Mult Scler Relat Disord 2020 May 26;43:102220. Epub 2020 May 26.

VA Connecticut Healthcare System, 950 Campbell Avenue, West Haven, CT, 06516, USA; Yale University School of Medicine, 333 Cedar Street, New Haven, CT, 06510, USA; Pain Research, Informatics, Multimorbidities and Education (PRIME) Center, VA Connecticut Healthcare System, 950 Campbell Avenue, West Haven, CT, 06516, USA.

Background: As cognitive, emotional, and health-related behavioral issues are prevalent among persons with multiple sclerosis (MS), mental health services are a valuable component of comprehensive care. However, it is unknown how many participate in neuropsychological and psychotherapeutic services, and whether the presence of certain co-occurring conditions increase service use. This study aimed to examine the frequency and associated factors (e. Read More

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http://dx.doi.org/10.1016/j.msard.2020.102220DOI Listing

Prevalence and demographics of multiple sclerosis-associated uveitis: a UK biobank study.

Mult Scler Relat Disord 2020 May 23;43:102209. Epub 2020 May 23.

Preventive Neurology Unit, Wolfson Institute of Preventive Medicine, Queen Mary University of London, London, UK; Royal London Hospital, Barts Health NHS Trust, London, UK.

Background: Uveitis describes intraocular inflammation of the uveal tract. It may occur in the absence of a predisposing underlying condition, or may be secondary to a systemic autoimmune disease or ocular infection. An association with Multiple Sclerosis (MS) has also been observed. Read More

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http://dx.doi.org/10.1016/j.msard.2020.102209DOI Listing

Lower cortical gamma-aminobutyric acid level contributes to connectivity in sensory-motor inter-connected regions in progressive MS.

Mult Scler Relat Disord 2020 May 25;43:102183. Epub 2020 May 25.

Department of Neurology, Icahn School of Medicine at Mount Sinai, New York, NY, USA; Department of Radiology, Icahn School of Medicine at Mount Sinai, New York, NY, USA; Department of Neuroscience, Icahn School of Medicine at Mount Sinai, New York, NY, USA; Department of Neuroscience, Rehabilitation, Ophthalmology, Genetics, and Mother-Child health, University of Genoa, Genoa, Italy. Electronic address:

Background: Large-scale functional abnormalities and decreased synchronization between functionally connected regions within brain networks were reported in progressive multiple sclerosis (P-MS) patients. Low concentration of gamma-aminobutyric acid (GABA) was observed in the sensorimotor cortex (SMC) of these patients and was associated with reduced motor functions of limbs. Yet, the role of GABA in modulating functional connectivity (FC) has not been investigated in MS patients. Read More

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http://dx.doi.org/10.1016/j.msard.2020.102183DOI Listing

Benign course of COVID-19 in a multiple sclerosis patient treated with Ocrelizumab.

Mult Scler Relat Disord 2020 May 15;42:102201. Epub 2020 May 15.

Lincoln medical center, 234E 149th Street, the Bronx, NY, USA.

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http://dx.doi.org/10.1016/j.msard.2020.102201DOI Listing

Are type 1 interferons treatment in Multiple Sclerosis as a potential therapy against COVID-19?

Mult Scler Relat Disord 2020 May 16;42:102196. Epub 2020 May 16.

Department of Internal Medicine and Division of Rheumatology, Ankara City Hospital, Ankara, Turkey. Electronic address:

Background: The Coronavirus (COVID-19), (Severe Acute Respiratory Syndrome Coronavirus 2 (SARS-CoV-2)) has been spreading worldwide since its first identification in China. It has been speculated that patients with comorbidities and elderly patients could be at high risk for the pandemic reasoned respiratory insufficiency and death. At first, it was thought that the patients who use immunmodulator therapy could be even at higher risks of disease complications. Read More

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http://dx.doi.org/10.1016/j.msard.2020.102196DOI Listing

Congenital lymphedema as a rare and first symptom of tuberous sclerosis complex.

Gene 2020 May 29:144815. Epub 2020 May 29.

Institute of Human Genetics, Klinikum rechts der Isar, Technical University of Munich, School of Medicine, Munich, Germany. Electronic address:

Lymphedema are characterized by interstitial edema leading to swelling of extremities. They can be divided into primary and secondary lymphedema. Developmental abnormalities of the lymphatic system are responsible for the primary form of lymphedema. Read More

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http://dx.doi.org/10.1016/j.gene.2020.144815DOI Listing

Establishment of a simple one-step method for oligodendrocyte progenitor cell preparation from rodent brains.

J Neurosci Methods 2020 May 29:108798. Epub 2020 May 29.

Asubio Pharma Co., Ltd., 6-4-3 Minatojima-Minamimachi, Chuo-ku, Kobe, Hyogo 650-0047, Japan.

Background: Oligodendrocytes, which form myelin, enable rapid and efficient nerve conduction. Destruction of myelin causes demyelinating diseases such as multiple sclerosis. Primary oligodendrocyte progenitor cells (OPCs) from postnatal rodents have been utilized to elucidate the developmental mechanism of oligodendrocytes in vitro. Read More

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http://dx.doi.org/10.1016/j.jneumeth.2020.108798DOI Listing

FUS ALS-causative mutations impair FUS autoregulation and splicing factor networks through intron retention.

Nucleic Acids Res 2020 Jun 1. Epub 2020 Jun 1.

Department of Neuromuscular Diseases, UCL Queen Square Institute of Neurology, University College London, London WC1N 3BG, UK.

Mutations in the RNA-binding protein FUS cause amyotrophic lateral sclerosis (ALS), a devastating neurodegenerative disease. FUS plays a role in numerous aspects of RNA metabolism, including mRNA splicing. However, the impact of ALS-causative mutations on splicing has not been fully characterized, as most disease models have been based on overexpressing mutant FUS, which will alter RNA processing due to FUS autoregulation. Read More

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http://dx.doi.org/10.1093/nar/gkaa410DOI Listing

Umbilical cord-derived mesenchymal stem cells in neurodegenerative disorders: from literature to clinical practice.

Regen Med 2020 Jun 1. Epub 2020 Jun 1.

Department of Hematology, School of Allied Medical Sciences, Tehran University of Medical Sciences, Tehran 14177-44361, Iran.

Mesenchymal stem cells (MSCs) have provided a promising tool for cell therapy. Umbilical cord (UC) is one of the best sources of MSCs since its collection is noninvasive, and effortless, and the cells from this source are more capable and prolific. It has been proven that the differentiation, migration and protective properties of UC-MSCs are superior compared with other kinds of stem cells. Read More

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http://dx.doi.org/10.2217/rme-2019-0119DOI Listing

Explorative study of emerging blood biomarkers in progressive multiple sclerosis (EmBioProMS): Design of a prospective observational multicentre pilot study.

Contemp Clin Trials Commun 2020 Jun 19;18:100574. Epub 2020 May 19.

Department of Neurology, University Hospital of Ulm, Ulm, Germany.

Background: Defining clinical and subclinical progression in multiple sclerosis (MS) is challenging. Patient history, expanded disability status scale (EDSS), and magnetic resonance imaging (MRI) all have shortcomings and may underestimate disease dynamics. Emerging serum biomarkers such as glial fibrillary acidic protein (GFAP) and neurofilament light chain (NfL) proved useful in many cross-sectional studies. Read More

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http://dx.doi.org/10.1016/j.conctc.2020.100574DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7251538PMC

Four cases of progressive multifocal leukoencephalopathy in iatrogenic immunocompromised patients.

eNeurologicalSci 2020 Jun 17;19:100243. Epub 2020 May 17.

Department of Biomedicine, Neuroscience & Advanced Diagnostic, University of Palermo, Palermo, Italy.

Progressive multifocal leukoencephalopathy (PML) is a demyelinating disease of the central nervous system (CNS) caused by John Cunningham Virus (JCV). We report four PML cases in immunocompromised patients, respectively treated with (1) Natalizumab, (2) Rituximab, (3) autologous stem-cell transplantation, and (4) Tacrolimus. All patients underwent neurological examination, magnetic resonance imaging (MRI), magnetic resonance spectroscopy (MRS), JCV-DNA research on biological samples, and lymphocytes subpopulation study. Read More

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http://dx.doi.org/10.1016/j.ensci.2020.100243DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7248236PMC

A Systematic Review of the Neurocognitive Effects of Cannabis Use in Older Adults.

Curr Addict Rep 2019 Dec 22;6(4):443-455. Epub 2019 Oct 22.

Medical University of South Carolina, Charleston, South Carolina.

Purpose Of Review: Older adults currently represent the fastest growing demographic of cannabis users, yet few studies have investigated the effects of cannabis use on cognitive functioning in aging. We conducted a systematic review of the recent literature examining cognitive outcomes associated with cannabis use in older adults, with and without neurocognitive disorders, to clarify the potential neuroprotective benefits and risks of cognitive decline in this population.

Recent Findings: We identified 26 studies examining cognitive outcomes associated with medical and recreational use of cannabis in healthy aging, dementia, Parkinson's disease, multiple sclerosis, HIV, and pain populations. Read More

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http://dx.doi.org/10.1007/s40429-019-00285-9DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7259587PMC
December 2019

Spinal Cord Microglia in Health and Disease.

Acta Naturae 2020 Jan-Mar;12(1):4-17

Institute of Experimental Medicine, St. Petersburg, 197376 Russia.

The review summarizes data of recent experimental studies on spinal microglia, the least explored cells of the spinal cord. It focuses on the origin and function of microglia in mammalian spinal cord embryogenesis. The main approaches to the classification of microgliocytes based on their structure, function, and immunophenotypic characteristics are analyzed. Read More

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http://dx.doi.org/10.32607/actanaturae.10934DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7245960PMC

Ocrelizumab-induced alopecia areata-A series of five patients from Ontario, Canada: A case report.

SAGE Open Med Case Rep 2020 6;8:2050313X20919614. Epub 2020 May 6.

Division of Dermatology, Department of Medicine, McMaster University, Hamilton, ON, Canada.

Background: Ocrelizumab is a humanized monoclonal antibody that targets the CD20 antigen found on B-cells. It is indicated in the treatment of both relapsing-remitting multiple sclerosis and primary progressive multiple sclerosis.

Objective: The aim of this study is to report and describe the characteristics of alopecia areata following treatment with ocrelizumab for multiple sclerosis. Read More

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http://dx.doi.org/10.1177/2050313X20919614DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7233903PMC

A case report revealing acute onset psychosis and cognitive impairment as primary manifestation in relapsing-remitting multiple sclerosis.

Clin Case Rep 2020 May 4;8(5):833-836. Epub 2020 Mar 4.

Department of Radiology Aalborg University Hospital Aalborg Denmark.

Acute psychosis and cognitive impairment is a significant problem in RRMS. As it concerns in relatively young age group, our case report underscores the importance of early recognition which could impose diagnostic challenge in multiple sclerosis. Read More

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http://dx.doi.org/10.1002/ccr3.2781DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7250979PMC

Implications of COVID-19 Outbreak on Immune Therapies in Multiple Sclerosis Patients-Lessons Learned From SARS and MERS.

Front Immunol 2020 12;11:1059. Epub 2020 May 12.

Department of Neurology, Hanover Medical School, Hanover, Germany.

Severe acute respiratory syndrome coronavirus-2 (SARS-CoV-2) pandemic keeps the world in suspense. In addition to the fundamental challenges for the health care system, the individual departments must decide how to deal with patients at risk. Neurologists are confronted with the question, how they should advise their patients regarding immunosuppressive treatment. Read More

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http://dx.doi.org/10.3389/fimmu.2020.01059DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7235419PMC

Tolerizing Strategies for the Treatment of Autoimmune Diseases: From to Strategies.

Front Immunol 2020 14;11:674. Epub 2020 May 14.

VIB-UGent Center for Medical Biotechnology, Ghent University, Ghent, Belgium.

Autoimmune diseases such as multiple sclerosis (MS), type I diabetes (T1D), inflammatory bowel diseases (IBD), and rheumatoid arthritis (RA) are chronic, incurable, incapacitating and at times even lethal conditions. Worldwide, millions of people are affected, predominantly women, and their number is steadily increasing. Currently, autoimmune patients require lifelong immunosuppressive therapy, often accompanied by severe adverse side effects and risks. Read More

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http://dx.doi.org/10.3389/fimmu.2020.00674DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7241419PMC

Fingolimod Leads to Immediate Immunological Changes Within 6 h After First Administration.

Front Neurol 2020 12;11:391. Epub 2020 May 12.

Department of Neurology, Center of Clinical Neuroscience, University Hospital Dresden, Dresden, Germany.

Multiple effects of fingolimod have already been described. Here we investigated the acute effects on immune cell subsets and identified correlations with autonomic first dose phenomena and long-term immunological effects. Blood samples of 20 MS patients were analyzed using FACS. Read More

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http://dx.doi.org/10.3389/fneur.2020.00391DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7235319PMC

Experimental Models of Neuroimmunological Disorders: A Review.

Front Neurol 2020 12;11:389. Epub 2020 May 12.

Neuroinflammation and Neuroimmunology Laboratory, Brain Institute, Pontifical Catholic University of Rio Grande Do Sul (PUCRS), Porto Alegre, Brazil.

Immune-mediated inflammatory diseases of the central nervous system (CNS) are a group of neurological disorders in which inflammation and/or demyelination are induced by cellular and humoral immune responses specific to CNS antigens. They include diseases such as multiple sclerosis (MS), neuromyelitis optica spectrum disorders (NMOSD), acute disseminated encephalomyelitis (ADEM) and anti-NMDA receptor encephalitis (NMDAR encephalitis). Over the years, many and models were used to study clinical, pathological, physiological and immunological features of these neuroimmunological disorders. Read More

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http://dx.doi.org/10.3389/fneur.2020.00389DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7235321PMC

A. Juss Ameliorates Mouse Hepatitis Virus-Induced Neuroinflammatory Demyelination by Modulating Cell-to-Cell Fusion in an Experimental Animal Model of Multiple Sclerosis.

Front Cell Neurosci 2020 12;14:116. Epub 2020 May 12.

Department of Biological Sciences, Indian Institute of Science Education and Research Kolkata, Mohanpur, India.

Mouse hepatitis virus (MHV)-induced murine neuroinflammation serves as a model to study acute meningoencephalomyelitis, hepatitis, and chronic neuroinflammatory demyelination; which mimics certain pathologies of the human neurologic disease, multiple sclerosis (MS). MHV-induced acute neuroinflammation occurs due to direct glial cell dystrophy instigated by central nervous system (CNS)-resident microglia and astrocytes, in contrast to peripheral CD4+T cell-mediated myelin damage prevalent in the experimental autoimmune encephalomyelitis (EAE) model of MS. Viral envelope Spike glycoprotein-mediated cell-to-cell fusion is an essential mechanistic step for MHV-induced CNS pathogenicity. Read More

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http://dx.doi.org/10.3389/fncel.2020.00116DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7236902PMC

Five-year longitudinal changes in quantitative spinal cord MRI in multiple sclerosis.

Mult Scler 2020 Jun 1:1352458520923970. Epub 2020 Jun 1.

Department of Neurology, Johns Hopkins University, Baltimore, MD, USA.

Background: The spinal cord (SC) is highly relevant to disability in multiple sclerosis (MS), but few studies have evaluated longitudinal changes in quantitative spinal cord magnetic resonance imaging (SC-MRI).

Objectives: The aim of this study was to characterize the relationships between 5-year changes in SC-MRI with disability in MS.

Methods: In total, 75 MS patients underwent 3 T SC-MRI and clinical assessment (expanded disability status scale (EDSS) and MS functional composite (MSFC)) at baseline, 2 and 5 years. Read More

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http://dx.doi.org/10.1177/1352458520923970DOI Listing