83,203 results match your criteria Multiple Sclerosis


Tumefactive multiple sclerosis which initially presented with brainstem encephalitis with a long-term follow-up.

Mult Scler Relat Disord 2019 Apr 17;32:23-26. Epub 2019 Apr 17.

Department of Neurology, Tokyo Teishin Hospital, 2-14-23 Fujimi, Chiyoda-ku, Tokyo 102-8798, Japan.

Tumefactive demyelinating lesions (TDLs) are rare in multiple sclerosis (MS). We herein report a case of tumefactive MS which initially presented with brainstem encephalitis with a long-term follow-up. The patient had experienced relapse mostly in the brainstem in the first twenty years, and then in the periventricular white matter afterwards. Read More

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https://linkinghub.elsevier.com/retrieve/pii/S22110348193017
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http://dx.doi.org/10.1016/j.msard.2019.04.018DOI Listing
April 2019
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Capturing fatigue parameters: The impact of vagal processing in multiple sclerosis related cognitive fatigue.

Mult Scler Relat Disord 2019 Apr 13;32:13-18. Epub 2019 Apr 13.

Institute of Psychology, Carl von Ossietzy University of Oldenburg, Department VI - Medicine and Health Sciences, Ammerländer Heerstr. 114-11826129, Oldenburg, Germany; Klinikum Bremen-Ost, Department of Neurology, Züricher Str. 40, 28325 Bremen, Germany. Electronic address:

Background: Causes of fatigue in Multiple Sclerosis remain elusive. Recently, we developed a model linking cognitive fatigue to inflammatory processes based on a neuroinflammatory reflex-arc instantiated by the vagus nerve. The relation between experienced autonomic dysfunctions, based on vagal processing, and cognitive fatigue is well-known, but an examination of the association of objectively measured vagal activity and cognitive fatigue is missing. Read More

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https://linkinghub.elsevier.com/retrieve/pii/S22110348193017
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http://dx.doi.org/10.1016/j.msard.2019.04.013DOI Listing
April 2019
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Teriflunomide real-world evidence: Global differences in the phase 4 Teri-PRO study.

Mult Scler Relat Disord 2019 Mar 30;31:157-164. Epub 2019 Mar 30.

St. Josef-Hospital, Ruhr University Bochum, Gudrunstrasse 56, Bochum D-44791, Germany. Electronic address:

Background: The demographics and management of patients with multiple sclerosis (MS) differ across geographical regions, but it is unclear whether/how these differences affect treatment outcomes. The aim of this post-hoc analysis was to assess teriflunomide use and patient-reported outcomes in the United States (US) and the rest of the world (ROW) in the phase 4 Teri-PRO study (NCT01895335).

Methods: In the phase 4, real-world, Teri-PRO study, patients with relapsing forms of MS received teriflunomide for 48 weeks according to local labeling. Read More

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https://linkinghub.elsevier.com/retrieve/pii/S22110348193014
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http://dx.doi.org/10.1016/j.msard.2019.03.022DOI Listing
March 2019
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Quality of life in patients with multiple sclerosis: A study with patients and caregivers.

Disabil Health J 2019 Mar 28. Epub 2019 Mar 28.

Department of Applied Psychology, School of Psychology, University of Minho, Braga, Portugal. Electronic address:

Background: Multiple Sclerosis (MS) is a chronic disease that affects patients' quality of life and requires long term demanding care.

Objective: The purpose of this study was to examine the relationships between patients and caregivers' variables regarding patients' quality of life, the moderating role of marital satisfaction between patients' psychological morbidity and quality of life, and the contribution of patient and caregiver variables towards patients' quality of life.

Methods: The sample included 100 patients with MS and 72 caregivers. Read More

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http://dx.doi.org/10.1016/j.dhjo.2019.03.007DOI Listing

Tuberous Sclerosis Complex Genotypes and Developmental Phenotype.

Pediatr Neurol 2019 Mar 13. Epub 2019 Mar 13.

Department of Pediatrics, Division of Medical Genetics, McGovern Medical School, University of Texas Health Science Center at Houston, Houston, Texas.

Background: Children with tuberous sclerosis complex (TSC), caused by pathogenic variants in TSC1/TSC2, are at risk for intellectual disability. TSC2 pathogenic variants appear to increase the risk, compared with TSC1. However, the effect of TSC2 pathogenic variants on early and specific domains of development hasn't been studied. Read More

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http://dx.doi.org/10.1016/j.pediatrneurol.2019.03.003DOI Listing

Fifty Shades of Microglia.

Trends Neurosci 2019 Apr 17. Epub 2019 Apr 17.

Department of Pathology and Immunology, Washington University in St. Louis, St. Louis, MO, USA. Electronic address:

In a recent study, Masuda and colleagues (Nature 2019;566:388-392) used single-cell RNA-sequencing (scRNA-seq) to profile microglia across different anatomical compartments, developmental stages, and types of brain pathology in mice. Moreover, the authors performed a novel transcriptomic characterization of microglia from multiple sclerosis patients and identified phenotypically conserved microglial subsets between species. These findings, together with seminal prior results from various groups, provide valuable insights into the spatiotemporal heterogeneity of microglia during brain development and disease. Read More

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http://dx.doi.org/10.1016/j.tins.2019.03.010DOI Listing

Evaluation of a web-based fall prevention program among people with multiple sclerosis.

Mult Scler Relat Disord 2019 Apr 13;31:151-156. Epub 2019 Apr 13.

Oregon Health & Science University, VA Portland Health Care System, 3710 SW US Veterans Hospital Road, Portland, OR 97239, USA. Electronic address:

Background: Falls are common and impactful in people with multiple sclerosis (MS) but currently there is no accepted standard of care for fall prevention in MS. Evidence supports that the in-person, group-based, Free from Falls (FFF) program is associated with both immediate and six-month sustained improvements in mobility and balance and a reduction in falls, but program attendance is limited by access to the class at a given time and location and by the cost and availability of trained facilitators. Therefore, we developed and evaluated an online, web-based version of FFF, Free from Falls Online (FFFO). Read More

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https://linkinghub.elsevier.com/retrieve/pii/S22110348193017
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http://dx.doi.org/10.1016/j.msard.2019.04.015DOI Listing
April 2019
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Protective function of autophagy during VLCFA-induced cytotoxicity in a neurodegenerative cell model.

Free Radic Biol Med 2019 Apr 17. Epub 2019 Apr 17.

Université de Bourgogne Franche-Comté, Dijon, F-21000, France; Team 'Biochemistry of the Peroxisome, Inflammation and Lipid Metabolism' EA 7270, Inserm, F-21000, Dijon, France. Electronic address:

In recent years, a particular interest has focused on the accumulation of fatty acids with very long chains (VLCFA) in the occurrence of neurodegenerative diseases such as Alzheimer's disease, multiple sclerosis or dementia. Indeed, it seems increasingly clear that this accumulation of VLCFA in the central nervous system is accompanied by a progressive demyelination resulting in death of neuronal cells. Nevertheless, molecular mechanisms by which VLCFA result in toxicity remain unclear. Read More

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http://dx.doi.org/10.1016/j.freeradbiomed.2019.04.016DOI Listing

Rapamycin relieves inflammation of experimental autoimmune encephalomyelitis by altering the balance of Treg/Th17 in a mouse model.

Neurosci Lett 2019 Apr 17. Epub 2019 Apr 17.

Department of Neurology, the second Hospital of Hebei Medical University, ShiJiaZhuang, Hebei, 050000, China.

This study was to observed the different doses of rapamycin on the treatment of experimental autoimmune encephalomyelitis (EAE) in C57BL/6 mice. 63 female C57BL/6 mice (6-8 weeks) was chosen and randomly divided into three groups: control, low-dose rapamycin-treated EAE mice (0.3 mg/kg), and high-dose rapamycin-treated EAE mice (1 mg/kg). Read More

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http://dx.doi.org/10.1016/j.neulet.2019.04.035DOI Listing

Determine safety of outpatient chemotherapy and autotransplants using refrigerated, non-frozen grafts in persons with multiple sclerosis.

Clin Transplant 2019 Apr 20:e13567. Epub 2019 Apr 20.

Centro de Hematología y Medicina Interna de Puebla, Puebla, México.

Persons with multiple sclerosis (MS) are sometimes treated with intermediate- or high-dose chemotherapy and an autotransplant (1, 2). More than 1000 autotransplants are reported with MS (2-6) but use of autotransplants may be substantially more common as many cases are not reported. Recent data from a small randomized trial of less-intensive chemotherapy reported better outcomes with this approach compared with disease-modifying therapy in persons with advanced relapsing-remitting MS (7). Read More

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http://dx.doi.org/10.1111/ctr.13567DOI Listing

In search of distinct MS-related fatigue subtypes: results from a multi-cohort analysis in 1.403 MS patients.

J Neurol 2019 Apr 19. Epub 2019 Apr 19.

Department of Neurology, Medical Faculty, Heinrich Heine University Düsseldorf, Düsseldorf, Germany.

Fatigue is among the most disabling symptoms in patients with multiple sclerosis (PwMS). The common distinction between cognitive and motor fatigue is typically incorporated in self-rating instruments, such as the Chalder Fatigue Questionnaire (CFQ), the Fatigue Scale for Motor and Cognitive Functions (FSMC) or the Modified Fatigue Impact Scale (MFIS). The present study investigated the factor structure of the CFQ, the FSMC and the MFIS utilizing exploratory (EFA) and confirmatory factor analysis (CFA) as well as exploratory structural equation modeling (ESEM). Read More

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http://dx.doi.org/10.1007/s00415-019-09311-2DOI Listing

Temporal lobe epilepsy: Hippocampal pathology modulates connectome topology and controllability.

Neurology 2019 Apr 19. Epub 2019 Apr 19.

From the Neuroimaging of Epilepsy Laboratory (B.C.B., F.F., M.L., B.C., A.B., N.B.) and Multimodal Imaging and Connectome Analysis Laboratory (B.C.B.), McConnell Brain Imaging Centre, Montreal Neurological Institute and Hospital, McGill University, Canada; Department of Bioengineering and Electrical and Systems Engineering (S.G., D.S.B.), University of Pennsylvania, Philadelphia; and York Neuroimaging Center (E.J., J.S.), University of York, UK.

Objective: To assess whether hippocampal sclerosis (HS) severity is mirrored at the level of large-scale networks.

Methods: We studied preoperative high-resolution anatomical and diffusion-weighted MRI of 44 temporal lobe epilepsy (TLE) patients with histopathologic diagnosis of HS (n = 25; TLE-HS) and isolated gliosis (n = 19; TLE-G) and 25 healthy controls. Hippocampal measurements included surface-based subfield mapping of atrophy and T2 hyperintensity indexing cell loss and gliosis, respectively. Read More

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http://dx.doi.org/10.1212/WNL.0000000000007447DOI Listing
April 2019
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Diagnosing and quantifying a common deficit in multiple sclerosis: Internuclear ophthalmoplegia.

Neurology 2019 Apr 19. Epub 2019 Apr 19.

From Amsterdam UMC (J.A.N.B., L.J.B., A.P.), Vrije Universiteit Amsterdam, Department of Neurology, MS Center and Neuro-ophthalmology Expertise Center, Neuroscience Amsterdam; Amsterdam UMC (J.A.N.B., L.J.v.R., H.S.T., A.P.), Vrije Universiteit Amsterdam, Department of Ophthalmology, Neuro-ophthalmology Expertise Center, Neuroscience Amsterdam; Onze Lieve Vrouwe Gasthuis (L.J.v.R., B.M.J.U.), Department of Ophthalmology, Amsterdam, the Netherlands; and Moorfields Eye Hospital and the National Hospital for Neurology and Neurosurgery (A.P.), London, UK.

Objective: We present an objective and quantitative approach for diagnosing internuclear ophthalmoplegia (INO) in multiple sclerosis (MS).

Methods: A validated standardized infrared oculography protocol (DEMoNS [Demonstrate Eye Movement Networks with Saccades]) was used for quantifying prosaccades in patients with MS and healthy controls (HCs). The versional dysconjugacy index (VDI) was calculated, which describes the ratio between the abducting and adducting eye. Read More

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http://dx.doi.org/10.1212/WNL.0000000000007499DOI Listing

New age for progressive multiple sclerosis.

Authors:
Jaime Imitola

Proc Natl Acad Sci U S A 2019 Apr 19. Epub 2019 Apr 19.

Laboratory for Neural Stem Cells and Functional Neurogenetics, Progressive Multiple Sclerosis Clinic and Translational Research Program, Division of Neuroimmunology and Multiple Sclerosis, Department of Neurology, The Ohio State University Neurological Institute, The Ohio State University, Columbus, OH 43221

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http://www.pnas.org/lookup/doi/10.1073/pnas.1903796116
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http://dx.doi.org/10.1073/pnas.1903796116DOI Listing
April 2019
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MAPK pathway and B cells overactivation in multiple sclerosis revealed by phosphoproteomics and genomic analysis.

Proc Natl Acad Sci U S A 2019 Apr 19. Epub 2019 Apr 19.

Center of Neuroimmunology, Institut d'Investigacions Biomèdiques August Pi Sunyer, Barcelona 08036, Spain;

Dysregulation of signaling pathways in multiple sclerosis (MS) can be analyzed by phosphoproteomics in peripheral blood mononuclear cells (PBMCs). We performed in vitro kinetic assays on PBMCs in 195 MS patients and 60 matched controls and quantified the phosphorylation of 17 kinases using xMAP assays. Phosphoprotein levels were tested for association with genetic susceptibility by typing 112 single-nucleotide polymorphisms (SNPs) associated with MS susceptibility. Read More

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http://dx.doi.org/10.1073/pnas.1818347116DOI Listing
April 2019
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GAS8 and its naturally occurring antisense RNA as biomarkers in multiple sclerosis.

Immunobiology 2019 Apr 13. Epub 2019 Apr 13.

Urogenital Stem Cell Research Center, Shahid Beheshti University of Medical Sciences, Tehran, Iran. Electronic address:

Expressions of the Growth arrest specific 8 (GAS8) and its naturally occurring anti-sense RNA (GAS8-AS1) have been assessed in tumoral tissues of different origins. However, their association with immune-related disorders has been poorly understood. In the current study, we evaluated expression levels of these genes in 50 relapsing-remitting multiple sclerosis (RRMS) patients compared with age- and sex-matched controls. Read More

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https://linkinghub.elsevier.com/retrieve/pii/S01712985193004
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http://dx.doi.org/10.1016/j.imbio.2019.04.005DOI Listing
April 2019
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Vascular Aspects of Multiple Sclerosis: Emphasis on Perfusion and Cardiovascular Comorbidities.

Expert Rev Neurother 2019 Apr 19. Epub 2019 Apr 19.

a Buffalo Neuroimaging Analysis Center, Department of Neurology , Jacobs School of Medicine and Biomedical Sciences, University at Buffalo, State University of New York , Buffalo , NY , USA.

Introduction: Multiple sclerosis (MS) is a chronic inflammatory, demyelinating, and neurodegenerative disease of the central nervous system. Over the last two decades, more favorable MS long-term outcomes have contributed towards increase in prevalence of the aged MS population. Emergence of age-associated pathology, such as cardiovascular diseases, may interact with the MS pathophysiology and further contribute to disease progression. Read More

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https://www.tandfonline.com/doi/full/10.1080/14737175.2019.1
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http://dx.doi.org/10.1080/14737175.2019.1610394DOI Listing
April 2019
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Worsening of disability caused by relapses in multiple sclerosis: A different approach.

Mult Scler Relat Disord 2019 Apr 15;32:1-8. Epub 2019 Apr 15.

The Danish Multiple Sclerosis Registry, Department of Neurology, Rigshospitalet, Copenhagen, Denmark; Department of Neurology, Danish Multiple Sclerosis Center Rigshospitalet, University of Copenhagen, Denmark.

Background: In multiple sclerosis (MS) the quantitative role of relapses in Expanded Disability Status Scale (EDSS) worsening beyond the recovery phase is not well known. Most studies have examined the predictive role of early relapses in more distant endpoints. Relapses and worsening may be associated because they could be independent effects of the same underlying disease characteristics without causal relationship. Read More

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https://linkinghub.elsevier.com/retrieve/pii/S22110348193017
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http://dx.doi.org/10.1016/j.msard.2019.04.017DOI Listing
April 2019
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Small Molecules with Big Promises for Curing Demyelinating Diseases.

Cell Chem Biol 2019 Apr;26(4):468-470

Department of Pharmacological Sciences, Icahn School of Medicine at Mount Sinai, New York, NY 10029, USA. Electronic address:

Myelin regeneration by myelinating oligodendrocytes is key to neuronal damage repair for treatment of neurological disorders such as multiple sclerosis. In this issue of Cell Chemical Biology, Allimuthu et al. (2019) report new small molecule inhibitors of cholesterol biosynthesis enzymes that enhance oligodendrocyte formation and subsequent remyelination. Read More

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https://linkinghub.elsevier.com/retrieve/pii/S24519456193012
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http://dx.doi.org/10.1016/j.chembiol.2019.04.006DOI Listing
April 2019
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High-grade Oncocytic Tumor (HOT) of Kidney in a Patient with Tuberous Sclerosis Complex.

Histopathology 2019 Apr 19. Epub 2019 Apr 19.

Department of Pathology, Charles University, Medical Faculty and Charles University Hospital Plzen, Czech Republic.

High-grade oncocytic tumor (HOT) was recently proposed as a novel renal entity that is currently not included in the WHO classification. The first published series by He et al included 14 tumors, collected from multiple institutional files. Recently, Chen et al reported another series of 7 morphologically very similar tumors that they designated "sporadic renal cell carcinomas with eosinophilic and vacuolated cytoplasm". Read More

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http://dx.doi.org/10.1111/his.13876DOI Listing

Limb apraxia profiles in different clinical samples.

Clin Neuropsychol 2019 Apr 19:1-26. Epub 2019 Apr 19.

a University of Konstanz , Konstanz , Germany.

Objective: Limb apraxia is a motor cognitive disorder that has been mainly studied in patients with dementia or left hemisphere stroke (LHS). However, limb apraxia has also been reported in patients with right hemisphere stroke (RHS), multiple sclerosis (MS) or traumatic brain injury (TBI). This study's aim was to report detailed praxis performance profiles in samples suffering from these different neurological disorders by use of the Diagnostic Instrument for Limb Apraxia (DILA-S). Read More

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https://www.tandfonline.com/doi/full/10.1080/13854046.2019.1
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http://dx.doi.org/10.1080/13854046.2019.1585575DOI Listing
April 2019
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A complex relation between depression and multiple sclerosis: a descriptive review.

Neurol Sci 2019 Apr 18. Epub 2019 Apr 18.

IRCCS Centro Neurolesi "Bonino-Pulejo", S.S. 113 Via Palermo, C.da Casazza, 98124, Messina, Italy.

Background: Multiple sclerosis (MS) is a demyelinating neurodegenerative disease that affects central nervous system (CNS). MS patients are more likely to develop depressive symptoms than patients with other chronic diseases.

Objective: In this review, we have analysed if there is a correlation between brain lesions (BL), structural damage (SD) and depressive symptoms (DS). Read More

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http://link.springer.com/10.1007/s10072-019-03889-1
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http://dx.doi.org/10.1007/s10072-019-03889-1DOI Listing
April 2019
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Fruit Extract Ameliorates Experimental Autoimmune Encephalomyelitis through the Regulation of Th1/Th17 Cells.

Evid Based Complement Alternat Med 2019 14;2019:6797030. Epub 2019 Mar 14.

Department of Life Science, Institute of Biotechnology, National Tsing Hua University, Hsinchu 30013, Taiwan.

is a traditional Chinese medicine widely used for treating diarrhea, ulceration, and enuresis. Moreover, is effective for cognitive function improvement and nerve regeneration. Multiple sclerosis (MS) is a chronic neuronal inflammatory autoimmune disease that commonly affects young adults in high-latitude regions. Read More

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https://www.hindawi.com/journals/ecam/2019/6797030/
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http://dx.doi.org/10.1155/2019/6797030DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6437745PMC
March 2019
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Epstein-Barr Virus and miRNAs: Partners in Crime in the Pathogenesis of Multiple Sclerosis?

Front Immunol 2019 3;10:695. Epub 2019 Apr 3.

Department of Microbiology and Immunology, College of Medicine and Health Sciences, United Arab Emirates University, Al Ain, United Arab Emirates.

MicroRNAs (miRNAs) are small non-coding RNAs that modulate gene expression post transcriptionally. In healthy individuals, miRNAs contribute to maintaining gene expression homeostasis. However, the level of miRNAs expressed is markedly altered in different diseases, including multiple sclerosis (MS). Read More

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https://www.frontiersin.org/article/10.3389/fimmu.2019.00695
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http://dx.doi.org/10.3389/fimmu.2019.00695DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6456696PMC
April 2019
2 Reads

Three-Dimensional Magnetic Resonance Imaging (MRI) of Mouse Facial Nerve Regeneration.

Front Neurol 2019 2;10:310. Epub 2019 Apr 2.

Institute of Physiological Chemistry, Ulm University, Ulm, Germany.

MRI (magnetic resonance imaging) is an indispensable tool in the diagnosis of centrals nervous system (CNS) disorders such as spinal cord injury and multiple sclerosis (MS). In contrast, diagnosis of peripheral nerve injuries largely depends on clinical and electrophysiological parameters. Thus, currently MRI is not regularly used which in part is due to small nerve calibers and isointensity with surrounding tissue such as muscles. Read More

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https://www.frontiersin.org/article/10.3389/fneur.2019.00310
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http://dx.doi.org/10.3389/fneur.2019.00310DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6454117PMC
April 2019
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Epidemiology and treatment of multiple sclerosis in elderly populations.

Nat Rev Neurol 2019 Apr 18. Epub 2019 Apr 18.

Jacobs Multiple Sclerosis Center for Treatment and Research, Department of Neurology, Jacobs School of Medicine and Biomedical Sciences, State University of New York (SUNY), Buffalo, NY, USA.

The prevalence of multiple sclerosis (MS) and the age of affected patients are increasing owing to increased longevity of the general population and the availability of effective disease-modifying therapies. However, ageing presents unique challenges in patients with MS largely as a result of their increased frequency of age-related and MS-related comorbidities as well as transition of the disease course from an inflammatory to a neurodegenerative phenotype. Immunosenescence (the weakening of the immune system associated with natural ageing) might be at least partly responsible for this transition, which further complicates disease management. Read More

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http://dx.doi.org/10.1038/s41582-019-0183-3DOI Listing
April 2019
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The Central Vein Sign in Radiologically Isolated Syndrome.

AJNR Am J Neuroradiol 2019 Apr 18. Epub 2019 Apr 18.

Division of Neurology (S.S., M.G., X.M., J.O.), Department of Medicine

Background And Purpose: Radiologically isolated syndrome describes asymptomatic individuals with incidental radiologic abnormalities suggestive of multiple sclerosis. Recent studies have demonstrated that >40% of white matter lesions in MS (and often substantially more) have visible central veins on MR imaging. This "central vein sign" reflects perivenous inflammatory demyelination and can assist in differentiating MS from other white matter disorders. Read More

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http://www.ajnr.org/lookup/doi/10.3174/ajnr.A6045
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http://dx.doi.org/10.3174/ajnr.A6045DOI Listing
April 2019
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Advances in the pathogenesis and treatment of autoimmunity.

Authors:
Kamal D Moudgil

Cell Immunol 2019 Apr 8. Epub 2019 Apr 8.

Department of Microbiology and Immunology, University of Maryland School of Medicine, Baltimore, MD 21201, United States; Department of Medicine, Division of Rheumatology, University of Maryland School of Medicine, Baltimore, MD 21201, United States; Baltimore VA Medical Center, Baltimore, MD 21201, United States. Electronic address:

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https://linkinghub.elsevier.com/retrieve/pii/S00088749193013
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http://dx.doi.org/10.1016/j.cellimm.2019.04.005DOI Listing
April 2019
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Comparison of sedentary behaviour questionnaires in people with multiple sclerosis.

Disabil Rehabil 2019 Apr 18:1-8. Epub 2019 Apr 18.

a School of Sport, Exercise and Rehabilitation Sciences, University of Birmingham , Birmingham , UK.

Background: People with multiple sclerosis are at risk of developing co-morbidities associated with sedentary behaviour. Despite an increase in studies examining sedentary behaviour in multiple sclerosis, researchers have not yet examined the appropriateness of the content or format of questionnaires assessing sedentary behaviour in multiple sclerosis.

Objective: Evaluate perceptions of sedentary behaviour questionnaires for people with multiple sclerosis. Read More

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https://www.tandfonline.com/doi/full/10.1080/09638288.2019.1
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http://dx.doi.org/10.1080/09638288.2019.1597179DOI Listing
April 2019
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Social capital components and social support of persons with multiple sclerosis: a systematic review of the literature from 2000 to 2018.

Disabil Rehabil 2019 Apr 18:1-13. Epub 2019 Apr 18.

c Neurology, Public Health, Disability Unit and Coma Research Centre , Fondazione IRCCS Istituto Neurologico Carlo Besta , Milan , Italy.

Purpose: To identify experiences of persons with multiple sclerosis (MS) in terms of social capital and its components (i.e., social networks, trust, and interpersonal relationships) and social support based on the current scientific knowledge. Read More

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http://dx.doi.org/10.1080/09638288.2019.1597182DOI Listing

Normal Visual Recovery after Optic Neuritis Despite Significant Loss of Retinal Ganglion Cells in Patients with Multiple Sclerosis.

Klin Monbl Augenheilkd 2019 Apr 18;236(4):425-428. Epub 2019 Apr 18.

Department of Ophthalmology, University of Lausanne, Jules-Gonin Eye Hospital, Lausanne, Switzerland.

Background: Optic neuritis (ON) is a frequent manifestation of demyelinating attack in multiple sclerosis (MS). Initial visual loss can vary from minimal to complete. Visual improvement occurs in about 95% of patients, some of them recovering to normal [visual acuity (VA), color vision, visual field (VF)]. Read More

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http://dx.doi.org/10.1055/a-0853-1721DOI Listing

A SCA7 premutation may be a novel Mendelian modifier of MS course: A case report.

Mult Scler Relat Disord 2019 Apr 13;31:148-150. Epub 2019 Apr 13.

Department of Clinical Neuroscience, Institute of Neuroscience and Physiology, The Sahlgrenska Academy, University of Gothenburg, Gothenburg, Sweden. Electronic address:

A proportion of patients with the phenotype of complex genetic disorders carry dominantly inherited Mendelian traits, exemplified by hereditary spastic paraparesis influencing pyramidal symptoms in some MS cases. We here describe a mutable ATXN7 gene, a SCA7 premutation, in a patient fulfilling contemporary definitions of primary progressive MS. His onset age, and onset with a severely progressive cerebellar ataxia syndrome, was outside the reported range of symptoms in a representative MS material. Read More

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https://linkinghub.elsevier.com/retrieve/pii/S22110348193016
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http://dx.doi.org/10.1016/j.msard.2019.04.009DOI Listing
April 2019
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Retinal oximetry: Metabolic imaging for diseases of the retina and brain.

Prog Retin Eye Res 2019 Apr 15. Epub 2019 Apr 15.

University of Iceland, Reykjavik, Iceland.

Retinal oximetry imaging of retinal blood vessels measures oxygen saturation of hemoglobin. The imaging technology is non-invasive and reproducible with remarkably low variability on test-retest studies and in healthy cohorts. Pathophysiological principles and novel biomarkers in several retinal diseases have been discovered, as well as possible applications for systemic and brain disease. Read More

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http://dx.doi.org/10.1016/j.preteyeres.2019.04.001DOI Listing
April 2019
3 Reads

Abdominal functional electrical stimulation for bowel management in multiple sclerosis.

Neurodegener Dis Manag 2019 Apr 18. Epub 2019 Apr 18.

Birmingham Community Healthcare NHS Foundation Trust, UK.

Functional constipation is common in multiple sclerosis (MS) and first line treatments are frequently ineffective. The current study explored the use of abdominal functional electrical stimulation (ABFES) for treating constipation in MS. Twenty people with MS and constipation (ROME IV criteria). Read More

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http://dx.doi.org/10.2217/nmt-2018-0043DOI Listing
April 2019
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[Extended optic neuropathy with myelin oligodendrocyte glycoprotein antibodies].

Rev Med Liege 2019 Apr;74(4):179-184

Service de Neurologie, CHU Liège, Belgique.

The discovery of autoantibodies targeting aquaporin-4 (AQP4) of astrocytes has improved the understanding and management of Neuromyelitis Optica Syndrome Disorders (NMO-SD), previously considered as a variant of multiple sclerosis. Later, the detection of MOG IgG1 antibodies, directed against an oligodendrocyte myelin glycoprotein, made it possible to distinguish pathologies with different clinical and prognostic particularities, then helping the clinician in his diagnostic and therapeutic approach. This clinical case aims to feature the clinical differences, prognosis and therapeutic solutions of these pathologies. Read More

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Perspectives on gender parity in bioanalysis: an interview with Lauren Stevenson.

Bioanalysis 2019 Apr 18. Epub 2019 Apr 18.

Development Biomarkers and Bioanalytical Sciences, Biogen, Cambridge, MA 02142, USA.

Biography Lauren is Senior Director, Development Biomarkers & Bioanalytical Sciences at Biogen, Cambridge, MA, USA where she leads a team of talented scientists, setting bioanalytical and biomarker strategies and developing pharmacokinetics (PK), immunogenicity and biomarker assays in support of programs at all stages of development, from discovery to post-marketing. Lauren's team currently supports over 40 therapeutic programs, delivering PK and immunogenicity strategy and execution for Biogen's large molecule, antisense oligonucleotide (ASO0 and gene therapy portfolio as well as developing biomarkers in support of multiple sclerosis, immunology, fibrosis, rare and neurodegenerative disease indications. Externally, Lauren engages the broader industry and regulatory agencies as an invited speaker and course instructor at multiple conferences and workshops each year. Read More

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https://www.future-science.com/doi/10.4155/bio-2019-0060
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http://dx.doi.org/10.4155/bio-2019-0060DOI Listing
April 2019
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Influence of genetic copy number variants of the human GLUT3 glucose transporter gene on protein expression, glycolysis and rheumatoid arthritis risk: A genetic replication study.

Mol Genet Metab Rep 2019 Jun 6;19:100470. Epub 2019 Apr 6.

Robert S. Boas Center for Genomics and Human Genetics, the Feinstein Institute for Medical Research, 350 Community Drive, Manhasset, New York, USA.

Objectives: The gene encoding glucose transporter 3 (GLUT3, ) is present in the human population at variable copy number. An overt disease phenotype of copy number variants has not been reported; however, deletion of has been previously reported to protect carriers from rheumatoid arthritis, implicating GLUT3 as a therapeutic target in rheumatoid arthritis. Here we aim to perform functional analysis of GLUT3 copy number variants in immune cells, and test the reported protective association of the GLUT3 copy number variants for rheumatoid arthritis in a genetic replication study. Read More

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http://dx.doi.org/10.1016/j.ymgmr.2019.100470DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6453668PMC

Analysis of serum interleukin(IL)-1α, IL-1β and IL-18 in patients with systemic sclerosis.

Clin Transl Immunology 2019 6;8(4):e1045. Epub 2019 Apr 6.

Rheumatology Group Centre for Inflammatory Diseases School of Clinical Sciences at Monash Health Monash University Clayton VIC Australia.

Objectives: Systemic sclerosis (SSc) is an autoimmune disease characterised by fibrosis, vascular dysfunction and immune dysregulation. The pathogenesis of SSc remains poorly understood, although studies have indicated a role for the innate immune response.

Methods: Here, we measured serum interleukin (IL)-1α, IL-1β and IL-18 levels in 105 SSc patients and 47 healthy controls (HC) and analysed them with respect to multiple clinical parameters. Read More

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https://onlinelibrary.wiley.com/doi/abs/10.1002/cti2.1045
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http://dx.doi.org/10.1002/cti2.1045DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6451750PMC
April 2019
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Usefulness of [C] Methionine PET in the Differentiation of Tumefactive Multiple Sclerosis from High Grade Astrocytoma.

Neurol Med Chir (Tokyo) 2019 Apr 17. Epub 2019 Apr 17.

Department of Neurosurgery, Tokyo Medical and Dental University.

Tumefactive multiple sclerosis (tumefactive MS) is an atypical variant of MS characterized by a large isolated demyelinating lesion. Because tumefactive MS mimics high grade astrocytoma clinically and radiologically, it is difficult to distinguish between the two using only traditional diagnostic modalities, such as routine magnetic resonance imaging. [C] methionine positron emission tomography (MET PET) has been known as a useful diagnostic tool for glioma. Read More

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http://dx.doi.org/10.2176/nmc.oa.2018-0287DOI Listing

Myelin repair stimulated by CNS-selective thyroid hormone action.

JCI Insight 2019 Apr 18;4(8). Epub 2019 Apr 18.

Department of Physiology & Pharmacology and Program in Chemical Biology, Oregon Health & Science University, Portland, Oregon, USA.

Oligodendrocyte processes wrap axons to form neuroprotective myelin sheaths, and damage to myelin in disorders, such as multiple sclerosis (MS), leads to neurodegeneration and disability. There are currently no approved treatments for MS that stimulate myelin repair. During development, thyroid hormone (TH) promotes myelination through enhancing oligodendrocyte differentiation; however, TH itself is unsuitable as a remyelination therapy due to adverse systemic effects. Read More

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http://dx.doi.org/10.1172/jci.insight.126329DOI Listing

Towards a standard MRI protocol for multiple sclerosis across the UK.

Br J Radiol 2019 Apr 17:20180926. Epub 2019 Apr 17.

7 Department of Diagnostic and Interventional Neuroradiology, Hannover Medical School , Hannover , Germany.

Multiple sclerosis (MS) is a chronic inflammatory demyelinating and degenerative disease of the central nervous system. It is the most common non-traumatic cause of chronic disability in young adults. An early and accurate diagnosis, and effective disease modifying treatment (DMT) are key elements of optimum care for people with MS (pwMS). Read More

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https://www.birpublications.org/doi/10.1259/bjr.20180926
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http://dx.doi.org/10.1259/bjr.20180926DOI Listing
April 2019
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Treatment in childhood central nervous system demyelinating disorders.

Dev Med Child Neurol 2019 Apr 16. Epub 2019 Apr 16.

Department of Pediatric Neurology, Faculty of Medicine, Hacettepe University, Ankara, Turkey.

The last two decades witnessed significant advances in the treatment of acquired demyelinating disorders: thirteen new agents have been approved for the treatment of multiple sclerosis in adults by the European Medicines Agency and US Food and Drug Administration in the last twenty years. Although the long-term efficacy and safety profiles of some new drugs are still being assessed in paediatric MS, clinicians may have to use them in the management of paediatric onset MS resistant to first-line medications, based on results obtained in adult-onset disease. This review summarizes the current approach to treatment in children with demyelinating syndromes. Read More

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https://onlinelibrary.wiley.com/doi/abs/10.1111/dmcn.14228
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http://dx.doi.org/10.1111/dmcn.14228DOI Listing
April 2019
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Estimating the Change in Renal Function During the First Year of Therapy in ANCA-Associated Vasculitis.

Kidney Int Rep 2019 Apr 13;4(4):594-602. Epub 2019 Feb 13.

Nephrology Division, Hôpital du Sacré-Coeur de Montréal, Québec, Canada.

Introduction: Studies in antineutrophil cytoplasmic autoantibody (ANCA)-associated vasculitis (AAV) consistently show that the months following diagnosis have the greatest impact on the long-term renal function. Yet, it remains uncertain how much early gain should be expected with treatment. We sought to determine the factors associated with the change in glomerular filtration rate (GFR) throughout the first year. Read More

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https://linkinghub.elsevier.com/retrieve/pii/S24680249193004
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http://dx.doi.org/10.1016/j.ekir.2019.02.005DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6451086PMC
April 2019
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Uro-Vaxom® versus placebo for the prevention of recurrent symptomatic urinary tract infections in participants with chronic neurogenic bladder dysfunction: a randomised controlled feasibility study.

Trials 2019 Apr 16;20(1):223. Epub 2019 Apr 16.

National Spinal Injuries Centre, Stoke Mandeville Hospital, Buckinghamshire Healthcare NHS Trust, Aylesbury, HP21 8AL, UK.

Background: Patients with lower neurogenic bladder dysfunction are at an increased risk of suffering from recurrent urinary tract infections. Recurrent symptomatic urinary tract infection is occasionally treated with antibiotics as a prophylactic prevention strategy. This risks increasing the frequency of antibiotic resistance. Read More

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https://trialsjournal.biomedcentral.com/articles/10.1186/s13
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http://dx.doi.org/10.1186/s13063-019-3275-xDOI Listing
April 2019
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Emotional disturbances in multiple sclerosis: A neuropsychological and fMRI study.

Cortex 2019 Mar 1;117:205-216. Epub 2019 Mar 1.

University of Strasbourg and CNRS, ICube Laboratory UMR 7357 and FMTS (Fédération de Médecine Translationnelle de Strasbourg), Team IMIS/Neurocrypto, Strasbourg, France; University Hospitals of Strasbourg, CMRR (Memory Resources and Research Centre), Geriatric Day Hospital, Geriatrics Department, Strasbourg, France.

Background: Emotional disturbances in multiple sclerosis (MS) are often explored in terms of affect recognition, with controversial results that likely reflect the high lesional heterogeneity. Patients' emotional experience, however, has seldom been studied and has never been explored using fMRI.

Objectives: To explore the emotional experience in MS and compare these data with fMRI measurements using for the first time real-life emotional scenes differing in valence and arousal. Read More

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http://dx.doi.org/10.1016/j.cortex.2019.02.017DOI Listing
March 2019
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Racial differences in retinal neurodegeneration as a surrogate marker for cortical atrophy in multiple sclerosis.

Mult Scler Relat Disord 2019 Apr 3;31:141-147. Epub 2019 Apr 3.

The Sastry Family Foundation, Advanced Imaging Laboratory, Department of Neurology, Wayne State University School of Medicine, 4201 St. Antoine, Detroit, MI, USA; Multiple Sclerosis Center, Wayne State University School of Medicine, Detroit, MI, USA. Electronic address:

Background: Multiple sclerosis (MS) has both an inflammatory and a neurodegenerative component, with gray matter (GM) atrophy being an important contributor to disability. Optical coherence tomography (OCT) may serve as a prognostic tool for neuroaxonal health by measuring ganglion cell inner plexiform layer (GCIPL) thickness. There is a paucity of literature regarding the effects of race on pathobiology of MS, as racial minorities are underrepresented in research studies. Read More

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http://dx.doi.org/10.1016/j.msard.2019.04.001DOI Listing
April 2019
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Whole-body vibration impedes the deterioration of postural control in patients with multiple sclerosis.

Mult Scler Relat Disord 2019 Apr 3;31:134-140. Epub 2019 Apr 3.

Department of Sport Science, University of Freiburg, Schwarzwaldstraße 175, 79117 Freiburg, Germany; Department of Biomechanics, Praxisklinik Rennbahn, Switzerland.

Objective: The current study aimed to investigate if whole-body vibration (WBV) might attenuate the processing functional and neuromuscular degeneration of postural control in patients with MS.

Design: Performance in postural control was assessed before and after 6 weeks of a control (CON) and a WBV intervention period.

Setting: Laboratory at the University of Freiburg & home-based training PARTICIPANTS: Out of 29 interested participants, 15 subjects with severe MS fit inclusion criteria. Read More

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http://dx.doi.org/10.1016/j.msard.2019.03.026DOI Listing
April 2019
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Functional Neurosonology Reveals Impaired Cerebrovascular Reactivity in Multiple Sclerosis.

J Neuroimaging 2019 Apr 16. Epub 2019 Apr 16.

Second Department of Neurology, "Attikon" Hospital, School of Medicine , University of Athens, Greece.

Background And Purpose: Vascular aspects like global cerebral hypoperfusion are frequently reported in patients with multiple sclerosis (MS). Although mechanistic question remains unanswered, this hemodynamic impairment may be caused by a widespread endothelial dysfunction. Furthermore, impaired cerebrovascular reactivity (CVR) has been described in patients with MS by means of hypercapnic perfusion magnetic resonance imaging (MRI). Read More

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http://dx.doi.org/10.1111/jon.12617DOI Listing
April 2019
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Low-intensity transcranial magnetic stimulation promotes the survival and maturation of newborn oligodendrocytes in the adult mouse brain.

Glia 2019 Apr 16. Epub 2019 Apr 16.

Menzies Institute for Medical Research, University of Tasmania, Hobart, Tasmania, Australia.

Neuronal activity is a potent extrinsic regulator of oligodendrocyte generation and central nervous system myelination. Clinically, repetitive transcranial magnetic stimulation (rTMS) is delivered to noninvasively modulate neuronal activity; however, the ability of rTMS to facilitate adaptive myelination has not been explored. By performing cre-lox lineage tracing, to follow the fate of oligodendrocyte progenitor cells in the adult mouse brain, we determined that low intensity rTMS (LI-rTMS), administered as an intermittent theta burst stimulation, but not as a continuous theta burst or 10 Hz stimulation, increased the number of newborn oligodendrocytes in the adult mouse cortex. Read More

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http://dx.doi.org/10.1002/glia.23620DOI Listing
April 2019
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